urea has been researched along with rki-1447 in 5 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 3 (60.00) | 2.80 |
| Authors | Studies |
|---|---|
| Forinash, KD; Lawrence, NJ; Martin, MP; Patel, RA; Pireddu, R; Schönbrunn, E; Sebti, SM; Sun, N; Sun, Y | 1 |
| Dang, Y; Loewen, NA; Loewen, RT; Shah, P; Wang, C; Waxman, S | 1 |
| Chang, H; Chen, H; Chen, Q; Huang, Y; Li, L; Li, P; Lu, M; Yu, Y | 1 |
| Jiang, W; Wang, J | 1 |
| Gao, L; Li, X; Ning, L; Wang, T; Zhang, F | 1 |
5 other study(ies) available for urea and rki-1447
| Article | Year |
|---|---|
RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer.
Topics: Animals; Antineoplastic Agents; Binding Sites; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Crystallography, X-Ray; Cytoskeleton; Humans; Mammary Neoplasms, Experimental; Mice; Mice, Transgenic; Models, Molecular; Molecular Structure; Neoplasm Invasiveness; NIH 3T3 Cells; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; rho-Associated Kinases; Substrate Specificity; Thiazoles; Tumor Burden; Urea | 2012 |
RKI-1447, a Rho kinase inhibitor, causes ocular hypotension, actin stress fiber disruption, and increased phagocytosis.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Glaucoma, Open-Angle; Intraocular Pressure; Ocular Hypotension; Phagocytosis; rho-Associated Kinases; Stress Fibers; Swine; Thiazoles; Trabecular Meshwork; Urea | 2019 |
RKI-1447 suppresses colorectal carcinoma cell growth via disrupting cellular bioenergetics and mitochondrial dynamics.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Endoplasmic Reticulum Stress; Energy Metabolism; Glycolysis; HCT116 Cells; Humans; Male; Mice; Mice, Inbred BALB C; Mitochondria; Mitochondrial Dynamics; Neoplasm Invasiveness; Reactive Oxygen Species; rho-Associated Kinases; Signal Transduction; Thiazoles; Transcription Factor CHOP; Urea; Xenograft Model Antitumor Assays | 2020 |
The Effects of RKI-1447 in a Mouse Model of Nonalcoholic Fatty Liver Disease Induced by a High-Fat Diet and in HepG2 Human Hepatocellular Carcinoma Cells Treated with Oleic Acid.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carcinoma, Hepatocellular; Cholesterol; Diet, High-Fat; Disease Models, Animal; Glucose Tolerance Test; Hep G2 Cells; Humans; Insulin Resistance; Interleukin-6; Liver; Liver Neoplasms; Male; Malondialdehyde; Mice, Inbred ICR; Models, Biological; Non-alcoholic Fatty Liver Disease; Oleic Acid; Oxidative Stress; rhoA GTP-Binding Protein; Signal Transduction; Superoxide Dismutase; Thiazoles; Triglycerides; Tumor Necrosis Factor-alpha; Urea | 2020 |
Mechanical Stretch Induces Annulus Fibrosus Cell Senescence through Activation of the RhoA/ROCK Pathway.
Topics: Animals; Annulus Fibrosus; Cell Proliferation; Cells, Cultured; Cellular Senescence; G1 Phase Cell Cycle Checkpoints; Intervertebral Disc Degeneration; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; rho GTP-Binding Proteins; rho-Associated Kinases; Signal Transduction; Stress, Mechanical; Telomerase; Thiazoles; Urea | 2021 |