urea has been researched along with rgb 286638 in 5 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| de Bruijn, P; de Jonge, MJ; Lam, MH; Loos, WJ; Meyer, T; Moghaddam-Helmantel, IM; Verweij, J; Wiemer, EA | 1 |
| Anderson, KC; Cirstea, D; Cottini, F; Eda, H; Gorgun, G; Hideshima, T; Hu, Y; Loferer, H; Mimura, N; Mishima, Y; Munshi, NC; Nemani, N; Ohguchi, H; Raje, N; Santo, L; Suzuki, R | 1 |
| Burger, H; de Bruijn, P; de Jonge, MJ; Lamers, CH; Loferer, H; Mathijssen, RH; Naus, N; van der Biessen, DA; Wiemer, EA | 1 |
| Giordano, A; Morales, F | 1 |
| Boufraqech, M; De Melo, MS; Del Rivero, J; Grant, RRC; Hall, MD; Laha, D; Mishra, P; Nilubol, N; Quezado, M; Shen, M; Zeiger, M; Zhang, YQ | 1 |
1 review(s) available for urea and rgb 286638
| Article | Year |
|---|---|
Overview of CDK9 as a target in cancer research.
Topics: Bridged Bicyclo Compounds, Heterocyclic; Cell Cycle; Cyclic N-Oxides; Cyclin-Dependent Kinase 9; Flavonoids; Humans; Indolizines; Molecular Targeted Therapy; Neoplasms; Oxazoles; Piperidines; Protein Kinase Inhibitors; Purines; Pyrazoles; Pyridinium Compounds; Roscovitine; Thiazoles; Urea | 2016 |
1 trial(s) available for urea and rgb 286638
| Article | Year |
|---|---|
Phase I study of RGB-286638, a novel, multitargeted cyclin-dependent kinase inhibitor in patients with solid tumors.
Topics: Adult; Aged; Antineoplastic Agents; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Female; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Protein Kinase Inhibitors; Pyrazoles; Urea | 2014 |
3 other study(ies) available for urea and rgb 286638
| Article | Year |
|---|---|
Validated bioanalytical method for the quantification of RGB-286638, a novel multi-targeted protein kinase inhibitor, in human plasma and urine by liquid chromatography/tandem triple-quadrupole mass spectrometry.
Topics: Calibration; Chemistry, Pharmaceutical; Chromatography, Liquid; Edetic Acid; Formates; Humans; Mass Spectrometry; Models, Chemical; Models, Statistical; Protein Kinase Inhibitors; Pyrazoles; Quality Control; Reference Standards; Reproducibility of Results; Tandem Mass Spectrometry; Temperature; Time Factors; Urea | 2009 |
Small-molecule multi-targeted kinase inhibitor RGB-286638 triggers P53-dependent and -independent anti-multiple myeloma activity through inhibition of transcriptional CDKs.
Topics: Animals; Apoptosis; Cyclin-Dependent Kinases; Humans; Male; Mice; Multiple Myeloma; Phosphorylation; Protein Kinase Inhibitors; Pyrazoles; Real-Time Polymerase Chain Reaction; Transcription, Genetic; Tumor Suppressor Protein p53; Urea; Xenograft Model Antitumor Assays | 2013 |
Preclinical assessment of synergistic efficacy of MELK and CDK inhibitors in adrenocortical cancer.
Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Animals; Apoptosis; beta Catenin; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinases; Cyclins; G2 Phase Cell Cycle Checkpoints; Glycogen Synthase Kinase 3; Humans; Mice; Protein Serine-Threonine Kinases; Pyrazoles; RNA, Messenger; Stathmin; Tubulin; Urea; Vimentin | 2022 |