urea has been researched along with pyrimidinones in 60 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.67) | 18.7374 |
| 1990's | 1 (1.67) | 18.2507 |
| 2000's | 20 (33.33) | 29.6817 |
| 2010's | 35 (58.33) | 24.3611 |
| 2020's | 3 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Agarwal, DP; Eickhoff, K; Goedde, HW | 1 |
| Dominguez, C; Galemmo, RA; Knabb, RM; Maduskuie, TP; Rossi, KA; Stouten, PF; Wexler, RR | 1 |
| Ma, Y; Qian, C; Wang, L; Yang, M | 1 |
| Corbin, PS; Lawless, LJ; Li, Z; Ma, Y; Witmer, MJ; Zimmerman, SC | 1 |
| Karelson, M; Katritzky, AR; Lomaka, A; Oliferenko, A | 1 |
| Dineshkumar, TK; Subbulakshmi, C; Thanedar, S; Varshney, U | 1 |
| Isaacs, L; Wu, A | 1 |
| Ahmad, R; Mishra, RC; Srivastava, AK; Srivastava, BS; Srivastava, R; Tewari, N; Tiwari, VK; Tripathi, RP | 1 |
| Brands, M; Endermann, R; Gahlmann, R; Grande, YC; Krüger, J; Raddatz, S | 1 |
| Betebenner, DA; Herrin, T; Norbeck, DW; Plattner, JJ; Rosenbrook, W; Saldivar, A; Sham, HL; Vasavanonda, S | 1 |
| Lusch, MJ; Tallarico, JA | 1 |
| Bannister, A; Day, SL; Fisher, M; Hankins, M; Leake Date, HA | 1 |
| Pan, YJ; Tung, CH; Wu, LZ; Zhang, LP; Zhao, CC; Zhao, YP | 1 |
| Aliev, AE; Hailes, HC; Horton, PN; Hursthouse, MB; Lafitte, VG | 1 |
| Kumar, H; Parmar, A | 1 |
| Ciftçi, M; Erol, K; Saraç, S; Tunç, O; Zorkun, IS | 1 |
| Jiang, H; Liu, C; Liu, D; Luo, G; Yu, Y | 1 |
| Khabazzadeh, H; Saidi, K; Sheibani, H | 1 |
| de Greef, TF; Ligthart, GB; Lutz, M; Meijer, EW; Sijbesma, RP; Spek, AL | 1 |
| Liu, CJ; Wang, JD | 2 |
| Pichlmaier, M; Winter, RF; Zabel, M; Zális, S | 1 |
| Gong, H; Jiang, H; Song, Z; Wang, M | 2 |
| Gong, P; Jin, YC; Liu, D; Qi, BH; Tan, HL; Yao, P; Zhai, X | 1 |
| Dixit, N; Mishra, L; Mishra, PC; Roesky, HW; Shukla, PK | 1 |
| Bretzke, S; Li, P; Menche, D; Morgen, M | 1 |
| Park, SY | 1 |
| Choi, KH; Chung, WC; Jung, SH; Kang, BK; Kang, BR; Kim, EJ; Kong, SE; Lee, KM; Oak, JH; Paik, CN | 1 |
| Hatnapure, GD; Keche, AP; Rodge, AH; Tale, RH | 1 |
| Banerjee, M; Basu, S; Chakrabarti, A; Pal, U; Subudhhi, A | 1 |
| Aarts, M; Ashworth, A; Garcia-Murillas, I; Gevensleben, H; Hurd, MS; Sharpe, R; Shumway, SD; Toniatti, C; Turner, NC | 1 |
| De, A; Dewan, M; Kumar, A; Mozumdar, S; Saxena, A | 1 |
| Bernard, J; Bertrand, A; Lortie, F | 1 |
| Arslan, M; Celik, F; Demir, D; Gençer, N; Yavuz, E | 1 |
| Arslan, M; Arslan, O; Celik, F; Gencer, N; Kaya, MO; Yavuz, E | 1 |
| Asadi, S; Heravi, MM; Lashkariani, BM | 1 |
| Banwell, MG; Lohmann, K; Renner, J; Sharp, PP; Willis, AC | 1 |
| Albertazzi, L; Bastings, MM; Dankers, PY; Kieltyka, RE; Meijer, EW; Nakano, Y; Pape, AC; Voets, IK | 1 |
| Sun, J; Yan, CG; Zhang, LL | 1 |
| Jacobs, J; Pereshivko, OP; Peshkov, AA; Peshkov, VA; Van der Eycken, EV; Van Meervelt, L | 1 |
| Ma, HT; Mak, JP; Man, WY; Poon, RY | 1 |
| Chow, JP; Ma, HT; Mak, JP; Man, WY; Poon, RY | 1 |
| Emilsen, E; Engesæter, B; Fjær, R; Flørenes, VA; Giller Fleten, K; Magnussen, GI; Nähse-Kumpf, V; Slipicevic, A | 1 |
| Bertoni, F; Carrassa, L; Chilà, R; Damia, G; Kwee, I; Lupi, M; Restelli, V; Rinaldi, A | 1 |
| Espinoza-Vázquez, A; González-Olvera, R; Negrón-Silva, GE; Rodríguez-Gómez, FJ; Román-Rodríguez, V; Santillan, R | 1 |
| Cao, D; Liu, C; Liu, Z; Ma, R | 1 |
| Bago-Horvath, Z; Fece de la Cruz, F; Haura, EB; Katz, AM; Kerzendorfer, C; Konopka, T; Loizou, JI; Mair, B; Mazouzi, A; Muellner, MK; Nagy-Bojarszky, K; Nijman, SM; Paz, K; Smida, M; Suchankova, T; Uras, IZ | 1 |
| Arribas, AJ; Bertoni, F; Carrassa, L; Damia, G; Restelli, V; Vagni, M | 1 |
| Hasvold, G; Hauge, S; Joel, M; Juzenas, P; Naucke, C; Rødland, GE; Stokke, T; Syljuåsen, RG | 1 |
| Ebeid, K; Ho, GN; Salem, AK | 1 |
| Frederick, M; Johnson, FM; Kalu, NN; Li, L; Mazumdar, T; Myers, JN; Peng, S; Pickering, CR; Sambandam, V; Shen, L; Singh, R; Tong, P; Wang, J; Zhang, M | 1 |
| Fu, R; Gao, H; Hu, H; Li, J; Ma, X; Sun, Y; Yang, Y; Yi, J; Zeng, X | 1 |
| Bakker, MH; Dankers, PYW; de Hingh, IH; Fransen, PKH; Grillaud, M; Wu, DJ | 1 |
| Baaijens, FPT; Bouten, CVC; Dankers, PYW; Di Luca, A; Thakkar, SH; Zaccaria, S | 1 |
| Carroll, KR; Elfers, EE; Hildeman, DA; Jordan, MB; Katz, JD; McNally, JP; Stevens, JJ | 1 |
| Bakker, MH; Dankers, PYW; Doevendans, PA; Goumans, MJ; Lei, Z; Mol, EA; Roefs, MT; Sluijter, JPG; Vader, P | 1 |
| Gardas, RL; Padrón, JM; Patel, DM; Patel, HM; Puerta, A; Ramkumar, V; Sharma, MG; Vala, RM | 1 |
| Brea, J; de Graaf, C; Egyed, A; Kelemen, ÁA; Keserű, GM; Leurs, R; Loza, MI; Thee, SA; Vass, M; Visegrády, A; Wang, Z | 1 |
| Ballereau, S; Blanger, C; Carivenc, C; Chalut, C; Génisson, Y; Guilhot, C; Maveyraud, L; Mourey, L; Nguyen, MC; Pedelacq, JD; Roy-Camille, C | 1 |
2 review(s) available for urea and pyrimidinones
| Article | Year |
|---|---|
Routes to Hydrogen Bonding Chain-End Functionalized Polymers.
Topics: Benzamides; Benzoic Acid; Carboxylic Acids; Hydrogen Bonding; Oligopeptides; Peptidomimetics; Polymerization; Polymers; Pyrimidinones; Triazines; Urea; Urethane | 2012 |
Recent progress in asymmetric Biginelli reaction.
Topics: Acetoacetates; Aldehydes; Catalysis; Pyrimidinones; Stereoisomerism; Urea | 2013 |
58 other study(ies) available for urea and pyrimidinones
| Article | Year |
|---|---|
Enzymatic preparation of labeled intermediates of thymine catabolism: dihydrothymine and beta-uridoisobutyric acid.
Topics: Aminoisobutyric Acids; Animals; Carbon Isotopes; Chromatography, Thin Layer; Liver; Propionates; Pyrimidinones; Swine; Thymine; Urea | 1968 |
The de novo design and synthesis of cyclic urea inhibitors of factor Xa: initial SAR studies.
Topics: Binding Sites; Drug Design; Factor Xa Inhibitors; Hydrogen Bonding; Imidazoles; Kinetics; Protein Conformation; Pyrimidinones; Serine Proteinase Inhibitors; Structure-Activity Relationship; Urea | 1998 |
Lanthanide triflate catalyzed Biginelli reaction. one-pot synthesis of dihydropyrimidinones under solvent-free conditions.
Topics: Acetoacetates; Benzaldehydes; Catalysis; Indicators and Reagents; Metals, Rare Earth; Models, Molecular; Molecular Conformation; Molecular Structure; Pyrimidinones; Urea; Ytterbium | 2000 |
Discrete and polymeric self-assembled dendrimers: hydrogen bond-mediated assembly with high stability and high fidelity.
Topics: Dimerization; Hydrogen Bonding; Models, Chemical; Models, Molecular; Nanotechnology; Pyrimidinones; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Time Factors; Urea | 2002 |
Six-membered cyclic ureas as HIV-1 protease inhibitors: a QSAR study based on CODESSA PRO approach. Quantitative structure-activity relationships.
Topics: HIV Protease Inhibitors; HIV-1; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Kinetics; Pyrimidinones; Quantitative Structure-Activity Relationship; Regression Analysis; Software; Urea | 2002 |
An unexpected absence of queuosine modification in the tRNAs of an Escherichia coli B strain.
Topics: Electrophoresis, Polyacrylamide Gel; Escherichia coli; Nucleoside Q; Pentosyltransferases; Pyrimidinones; Pyrroles; RNA, Bacterial; RNA, Transfer, Tyr; Urea | 2002 |
Self-sorting: the exception or the rule?
Topics: Binding, Competitive; Biomimetic Materials; Calixarenes; Hydrogen Bonding; Ionophores; Kinetics; Macromolecular Substances; Magnetic Resonance Spectroscopy; Pyrimidinones; Temperature; Urea | 2003 |
Synthesis and bioevaluation of glycosyl ureas as alpha-glucosidase inhibitors and their effect on mycobacterium.
Topics: Animals; Antitubercular Agents; Dose-Response Relationship, Drug; Glycoside Hydrolase Inhibitors; Glycosylation; Intestines; Mycobacterium; Pliability; Pyrimidinones; Rats; Structure-Activity Relationship; Urea | 2003 |
Pyrimidinone antibiotics--heterocyclic analogues with improved antibacterial spectrum.
Topics: Amino Acids; Anti-Bacterial Agents; Dipeptides; Gram-Positive Bacteria; Heterocyclic Compounds; Microbial Sensitivity Tests; Molecular Structure; Pyrimidinones; Stereoisomerism; Urea | 2003 |
Novel lopinavir analogues incorporating heterocyclic replacements of six-member cyclic urea--synthesis and structure-activity relationships.
Topics: Cell Line, Tumor; Enzyme Inhibitors; Heterocyclic Compounds; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Microbial Sensitivity Tests; Pyrimidinones; Structure-Activity Relationship; Urea | 2004 |
Demonstration of the feasibility of a direct solid-phase split-pool Biginelli synthesis of 3,4-dihydropyrimidinones.
Topics: Catalysis; Indicators and Reagents; Molecular Structure; Pyrimidinones; Temperature; Urea | 2004 |
Serum hypophosphatemia in tenofovir disoproxil fumarate recipients is multifactorial in origin, questioning the utility of its monitoring in clinical practice.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Blood Chemical Analysis; Creatinine; Fanconi Syndrome; Female; HIV Infections; Humans; Hypophosphatemia; Lopinavir; Male; Organophosphonates; Phosphates; Prospective Studies; Pyrimidinones; Reproducibility of Results; Tenofovir; Urea | 2005 |
First fluorescent sensor for fluoride based on 2-ureido-4[1H]-pyrimidinone quadruple hydrogen-bonded AADD supramolecular assembly.
Topics: Fluorides; Hydrogen Bonding; Macromolecular Substances; Pyrimidinones; Spectrometry, Fluorescence; Urea | 2006 |
Highly stable cyclic dimers based on non-covalent interactions.
Topics: Crystallography, X-Ray; Dimerization; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Magnetic Resonance Spectroscopy; Models, Molecular; Pyrimidinones; Tartrates; Urea | 2006 |
Ultrasound promoted ZrCl(4) catalyzed rapid synthesis of substituted 1,2,3,4-tetrahydropyrimidine-2-ones in solvent or dry media.
Topics: Aldehydes; Bentonite; Catalysis; Chlorides; Kinetics; Magnetic Resonance Spectroscopy; Pyrimidinones; Solvents; Ultrasonics; Urea; Zirconium | 2008 |
Studies on the synthesis and biological activitiy of 6-ethyl-4-aryl-5-methoxycarbonyl-3,4-dihydropyrimidin-2(1H)-ones.
Topics: Aldehydes; Animals; Benzaldehydes; Calcium Channel Blockers; Carotid Arteries; Crystallization; Female; Ileum; In Vitro Techniques; Indicators and Reagents; Magnetic Resonance Spectroscopy; Male; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Pyrimidinones; Rats; Sheep; Urea | 2007 |
An Efficient one-pot Biginelli condensation of aliphatic aldehydes catalyzed by zinc bromide under solvent-free conditions.
Topics: Aldehydes; Biotechnology; Bromides; Catalysis; Esters; Ketones; Pyrimidinones; Solvents; Time Factors; Urea; Zinc Compounds | 2007 |
Microwave-assisted synthesis of dihydropyrimidin-2(1H)-ones using graphite supported lanthanum chloride as a mild and efficient catalyst.
Topics: Aldehydes; Catalysis; Esters; Graphite; Ketones; Lanthanum; Microwaves; Pyrimidinones; Thiourea; Urea | 2008 |
The mechanism of ureido-pyrimidinone:2,7-diamido-naphthyridine complexation and the presence of kinetically controlled pathways in multicomponent hydrogen-bonded systems.
Topics: Binding Sites; Diamide; Dimerization; Hydrogen Bonding; Kinetics; Naphthyridines; Pyrimidinones; Urea | 2008 |
Copper(II) sulfamate: an efficient catalyst for the one-pot synthesis of 3,4-dihydropyrimidine-2(1H)-ones and thiones.
Topics: Acetates; Aldehydes; Catalysis; Copper; Molecular Structure; Pyrimidinones; Sulfonic Acids; Thiones; Urea | 2009 |
Electron transfer across multiple hydrogen bonds: the case of ureapyrimidinedione-substituted vinyl ruthenium and osmium complexes.
Topics: Crystallography, X-Ray; Dimerization; Electrochemistry; Electron Transport; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Osmium; Oxidation-Reduction; Pyrimidinones; Quantum Theory; Ruthenium; Solvents; Spectrophotometry; Urea | 2009 |
Copper nitrate catalyzed three-component one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones.
Topics: Aldehydes; Catalysis; Copper; Nitrates; Pyrimidinones; Urea | 2009 |
Synthesis and antiproliferative activity of novel diaryl ureas possessing a 4H-pyrido[1,2-a]pyrimidin-4-one group.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Pyrimidinones; Structure-Activity Relationship; Urea | 2010 |
Binding of urea and thiourea with a barbiturate derivative: experimental and theoretical approach.
Topics: Benzopyrans; Binding Sites; Calorimetry; Computer Simulation; Dimethyl Sulfoxide; Hydrogen Bonding; Luminescent Measurements; Models, Chemical; Pyrimidinones; Spectrophotometry, Ultraviolet; Urea; Water | 2010 |
Water-tolerant and reusable Lewis acid catalyst for the one-pot synthesis of 3,4-dihydropyrimidin-2-(1H)-ones under solvent-free conditions.
Topics: Acids; Aldehydes; Catalysis; Drug Compounding; Pyrimidinones; Solvents; Urea; Water | 2010 |
Ultrasound-assisted synthesis of novel 4-(2-phenyl-1,2,3-triazol-4-yl)-3,4-dihydropyrimidin-(1H)-(thio)ones catalyzed by Sm(ClO(4))(3).
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Antiviral Agents; Catalysis; Perchlorates; Pyrimidinones; Samarium; Thiourea; Triazoles; Ultrasonics; Urea | 2010 |
Stereodivergent synthesis of 1,3-syn- and -anti-tetrahydropyrimidinones.
Topics: Cyclization; Molecular Structure; Pyrimidinones; Stereoisomerism; Urea | 2010 |
[Effect of acid pump antagonist (Revaprazan, Revanex(R)) on the result of 13C urea breath test in the patients with Helicobacter pylori associated peptic ulcer disease].
Topics: Breath Tests; Carbon Isotopes; False Negative Reactions; Helicobacter Infections; Helicobacter pylori; Humans; Peptic Ulcer; Proton Pump Inhibitors; Pyrimidinones; Tetrahydroisoquinolines; Urea | 2011 |
[Effect of acid pump antagonist (Revaprazan, Revanex(R)) on result of 13C urea breath test in patients with Helicobacter pylori associated peptic ulcer disease].
Topics: Breath Tests; Carbon Isotopes; False Negative Reactions; Female; Helicobacter Infections; Helicobacter pylori; Humans; Male; Middle Aged; Peptic Ulcer; Proton Pump Inhibitors; Pyrimidinones; Tetrahydroisoquinolines; Urea | 2011 |
The novel 3,4-dihydropyrimidin-2(1H)-one urea derivatives of N-aryl urea: synthesis, anti-inflammatory, antibacterial and antifungal activity evaluation.
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents; Antifungal Agents; Interleukin-6; Microbial Sensitivity Tests; Pyrimidinones; Tumor Necrosis Factor-alpha; Urea | 2011 |
Interaction of Merocyanine 540 with serum albumins: photophysical and binding studies.
Topics: Animals; Binding Sites; Cattle; Circular Dichroism; Computer Simulation; Fluorescence Resonance Energy Transfer; Humans; Hydrophobic and Hydrophilic Interactions; Photosensitizing Agents; Protein Binding; Protein Denaturation; Protein Structure, Secondary; Protein Structure, Tertiary; Pyrimidinones; Serum Albumin; Serum Albumin, Bovine; Thermodynamics; Urea | 2012 |
Forced mitotic entry of S-phase cells as a therapeutic strategy induced by inhibition of WEE1.
Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Cycle Proteins; Cell Line; Cell Line, Tumor; Checkpoint Kinase 1; Cyclins; Deoxycytidine; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Female; Gemcitabine; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, SCID; Mitosis; Nuclear Proteins; Polycomb Repressive Complex 2; Protein Kinase Inhibitors; Protein Kinases; Protein-Tyrosine Kinases; Pyrazoles; Pyrimidines; Pyrimidinones; Quinolines; S Phase; Thiazoles; Thiophenes; Transcription Factors; Tumor Burden; Tumor Suppressor Protein p53; Urea; Xenograft Model Antitumor Assays | 2012 |
Biginelli reaction catalyzed by copper nanoparticles.
Topics: Acetoacetates; Aldehydes; Catalysis; Copper; Kinetics; Metal Nanoparticles; Microscopy, Electron, Transmission; Pyrimidinones; Urea; X-Ray Diffraction | 2012 |
Synthesis and carbonic anhydrase inhibitory properties of novel 1,4-dihydropyrimidinone substituted diarylureas.
Topics: Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Humans; In Vitro Techniques; Magnetic Resonance Spectroscopy; Pyrimidinones; Spectrophotometry, Infrared; Urea | 2014 |
Synthesis and carbonic anhydrase inhibitory properties of tetrazole- and oxadiazole substituted 1,4-dihydropyrimidinone compounds.
Topics: Benzaldehydes; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Enzyme Assays; Humans; Ketones; Oxadiazoles; Pyrimidinones; Sodium Azide; Solutions; Structure-Activity Relationship; Tetrazoles; Urea | 2014 |
Consecutive gold(I)-catalyzed cyclization reactions of o-(buta-1,3-diyn-1-yl-)-substituted N-aryl ureas: a one-pot synthesis of pyrimido[1,6-a]indol-1(2H)-ones and related systems.
Topics: Antineoplastic Agents; Aza Compounds; Catalysis; Cyclization; Gold; Indoles; Molecular Structure; Pyrimidines; Pyrimidinones; Urea | 2013 |
Mesoscale modulation of supramolecular ureidopyrimidinone-based poly(ethylene glycol) transient networks in water.
Topics: Carbamates; Models, Molecular; Molecular Conformation; Polyethylene Glycols; Pyrimidinones; Urea; Water | 2013 |
Synthesis of tetrahydropyrimidin-2-ones via FeCl3 catalyzed one-pot domino reaction of amines, methyl propiolate, aromatic aldehydes, and urea.
Topics: Aldehydes; Alkynes; Amines; Catalysis; Chemistry Techniques, Synthetic; Chlorides; Ferric Compounds; Propionates; Pyrimidinones; Urea | 2014 |
Unexpected regio- and chemoselectivity of cationic gold-catalyzed cycloisomerizations of propargylureas: access to tetrasubstituted 3,4-dihydropyrimidin-2(1H)-ones.
Topics: Catalysis; Cations; Crystallography, X-Ray; Cyclization; Gold; Isomerism; Pyrimidinones; Urea | 2014 |
Pharmacological targeting the ATR-CHK1-WEE1 axis involves balancing cell growth stimulation and apoptosis.
Topics: Apoptosis; Ataxia Telangiectasia Mutated Proteins; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Cycle Proteins; Cell Proliferation; Checkpoint Kinase 1; Flow Cytometry; Humans; Immunoenzyme Techniques; Lung Neoplasms; Mitosis; Nuclear Proteins; Protein Kinases; Protein-Tyrosine Kinases; Pyrazoles; Pyrimidines; Pyrimidinones; Thiophenes; Tumor Cells, Cultured; Urea | 2014 |
Pharmacological inactivation of CHK1 and WEE1 induces mitotic catastrophe in nasopharyngeal carcinoma cells.
Topics: Animals; Ataxia Telangiectasia Mutated Proteins; Carcinoma; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Checkpoint Kinase 1; DNA Damage; Flow Cytometry; G2 Phase; Gene Expression Regulation, Neoplastic; Green Fluorescent Proteins; HeLa Cells; Humans; Mice; Mice, Inbred BALB C; Mitosis; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neoplasm Invasiveness; Neoplasm Transplantation; Nuclear Proteins; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Protein-Tyrosine Kinases; Pyrazoles; Pyrimidines; Pyrimidinones; RNA Interference; Thiophenes; Urea | 2015 |
Combined inhibition of the cell cycle related proteins Wee1 and Chk1/2 induces synergistic anti-cancer effect in melanoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Checkpoint Kinase 2; Drug Synergism; Humans; Melanoma; Melanoma, Cutaneous Malignant; Mice; Nuclear Proteins; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrazoles; Pyrimidines; Pyrimidinones; Skin Neoplasms; Thiophenes; Urea; Xenograft Model Antitumor Assays | 2015 |
Characterization of a mantle cell lymphoma cell line resistant to the Chk1 inhibitor PF-00477736.
Topics: Antineoplastic Agents; Benzodiazepinones; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Checkpoint Kinase 1; Cyclin D1; Dasatinib; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Humans; Lymphoma, Mantle-Cell; Molecular Targeted Therapy; Nuclear Proteins; Protein Kinase Inhibitors; Protein Kinases; Protein-Tyrosine Kinases; Pyrazoles; Pyrimidines; Pyrimidinones; Signal Transduction; src-Family Kinases; Thiophenes; Time Factors; Urea | 2015 |
Multicomponent Synthesis and Evaluation of New 1,2,3-Triazole Derivatives of Dihydropyrimidinones as Acidic Corrosion Inhibitors for Steel.
Topics: Azides; Benzaldehydes; Catalysis; Corrosion; Pyrimidinones; Steel; Triazoles; Urea | 2016 |
New Efficient Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Catalyzed by Benzotriazolium-Based Ionic Liquids under Solvent-Free Conditions.
Topics: Aldehydes; Catalysis; Ionic Liquids; Pyrimidinones; Solvents; Urea | 2016 |
MEK inhibitors block growth of lung tumours with mutations in ataxia-telangiectasia mutated.
Topics: Animals; Ataxia Telangiectasia Mutated Proteins; Benzamides; Cell Line, Tumor; Cell Proliferation; Diphenylamine; Humans; Lung Neoplasms; Mice, Nude; Mutation; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Pyridones; Pyrimidinones; ras Proteins; RNA Interference; Thiophenes; Urea; Xenograft Model Antitumor Assays | 2016 |
Inhibition of CHK1 and WEE1 as a new therapeutic approach in diffuse large B cell lymphomas with MYC deregulation.
Topics: Cell Cycle Proteins; Cell Line; Checkpoint Kinase 1; Female; Humans; Lymphoma, Large B-Cell, Diffuse; Male; Nuclear Proteins; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-myc; Pyrazoles; Pyrimidines; Pyrimidinones; Thiophenes; Urea | 2018 |
Combined inhibition of Wee1 and Chk1 gives synergistic DNA damage in S-phase due to distinct regulation of CDK activity and CDC45 loading.
Topics: A549 Cells; Cell Cycle Proteins; Cell Line, Tumor; Checkpoint Kinase 1; Cyclin-Dependent Kinases; DNA Damage; DNA Replication; Drug Synergism; Flow Cytometry; Humans; Nuclear Proteins; Phenylurea Compounds; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrazines; Pyrazoles; Pyrimidines; Pyrimidinones; S Phase; Thiophenes; Urea | 2017 |
HPLC-UV method for simultaneous determination of MK-1775 and AZD-7762 in both acetonitrile-aqueous solution and mouse plasma.
Topics: Animals; Chromatography, High Pressure Liquid; Female; Limit of Detection; Linear Models; Mice; Mice, Inbred BALB C; Pyrazoles; Pyrimidines; Pyrimidinones; Reproducibility of Results; Solid Phase Extraction; Spectrophotometry, Ultraviolet; Thiophenes; Urea | 2017 |
Mutations of the LIM protein AJUBA mediate sensitivity of head and neck squamous cell carcinoma to treatment with cell-cycle inhibitors.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Checkpoint Kinase 1; Checkpoint Kinase 2; Dose-Response Relationship, Drug; G2 Phase Cell Cycle Checkpoints; Genotype; Head and Neck Neoplasms; Humans; LIM Domain Proteins; Mice, Nude; Molecular Targeted Therapy; Mutation; Nuclear Proteins; Phenotype; Polo-Like Kinase 1; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pteridines; Pyrazoles; Pyrimidines; Pyrimidinones; ras Proteins; RNA Interference; Signal Transduction; Smad4 Protein; Squamous Cell Carcinoma of Head and Neck; Thiophenes; Time Factors; Transfection; Tumor Burden; Urea; Xenograft Model Antitumor Assays | 2017 |
An Efficient, Eco-friendly and Sustainable One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Directly from Alcohols Catalyzed by Heteropolyanion-Based Ionic Liquids.
Topics: Alcohols; Aldehydes; Catalysis; Green Chemistry Technology; Ionic Liquids; Microwaves; Nitrates; Oxidation-Reduction; Polyelectrolytes; Polymers; Pyrimidinones; Thiourea; Urea | 2017 |
Cholesterol Modification of an Anticancer Drug for Efficient Incorporation into a Supramolecular Hydrogel System.
Topics: Antibiotics, Antineoplastic; Cell Death; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cholesterol; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Hydrogel, Polyethylene Glycol Dimethacrylate; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Macromolecular Substances; Mitomycin; Molecular Structure; Polyethylene Glycols; Pyrimidinones; Structure-Activity Relationship; Urea | 2018 |
Dual Electrospun Supramolecular Polymer Systems for Selective Cell Migration.
Topics: Cell Adhesion; Cell Movement; Chemokine CXCL12; Elasticity; Electrochemical Techniques; Humans; Hydrogels; Leukocytes, Mononuclear; Peptides; Polyesters; Polyethylene Glycols; Porosity; Primary Cell Culture; Pyrimidinones; Tissue Engineering; Tissue Scaffolds; Ultraviolet Rays; Urea | 2018 |
Extending Remission and Reversing New-Onset Type 1 Diabetes by Targeted Ablation of Autoreactive T Cells.
Topics: Animals; Diabetes Mellitus, Type 1; Enzyme Inhibitors; Imidazoles; Mice; Mice, Inbred NOD; Pancreas; Piperazines; Pyrazoles; Pyrimidines; Pyrimidinones; T-Lymphocytes; Thiophenes; Urea | 2018 |
Injectable Supramolecular Ureidopyrimidinone Hydrogels Provide Sustained Release of Extracellular Vesicle Therapeutics.
Topics: Animals; Cell Line; Delayed-Action Preparations; Drug Delivery Systems; Extracellular Signal-Regulated MAP Kinases; Extracellular Vesicles; Female; Humans; Hydrogels; Mice; Mice, Inbred BALB C; Molecular Weight; Polyethylene Glycols; Polymers; Pyrimidinones; Ultrafiltration; Urea | 2019 |
Synthesis and in vitro study of antiproliferative benzyloxy dihydropyrimidinones.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Lanthanum; Molecular Structure; Pyrimidinones; Structure-Activity Relationship; Urea | 2021 |
Controlling the selectivity of aminergic GPCR ligands from the extracellular vestibule.
Topics: Allosteric Site; Dose-Response Relationship, Drug; Humans; Ligands; Molecular Structure; Pyrimidinones; Receptors, G-Protein-Coupled; Structure-Activity Relationship; Urea | 2021 |
Phosphopantetheinyl transferase binding and inhibition by amidino-urea and hydroxypyrimidinethione compounds.
Topics: Bacterial Proteins; Binding Sites; Enzyme Inhibitors; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; Mycobacterium abscessus; Protein Binding; Pseudomonas aeruginosa; Pyrimidinones; Recombinant Proteins; Structure-Activity Relationship; Substrate Specificity; Transferases (Other Substituted Phosphate Groups); Urea | 2021 |