urea has been researched along with pyrimidine in 32 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (28.13) | 18.7374 |
| 1990's | 1 (3.13) | 18.2507 |
| 2000's | 2 (6.25) | 29.6817 |
| 2010's | 15 (46.88) | 24.3611 |
| 2020's | 5 (15.63) | 2.80 |
| Authors | Studies |
|---|---|
| Visek, WJ | 1 |
| Gerok, W; Häussinger, D; Holstege, A; Pausch, J; Rasenack, J | 1 |
| Nagasaki, T | 1 |
| Fico, ME; Milner, JA; Motyl, T | 1 |
| Bemm, U; Bergman, J; Goede, P; Langlet, A; Latypov, NV; Romero, I; Wellmar, U | 1 |
| FINK, K | 1 |
| MOHLER, WC | 1 |
| HIRAI, K; TAKAMIZAWA, A | 1 |
| ZIMMERMAN, M | 1 |
| CHARGAFF, E; DANON, A; RUEST, P; TEMPERLI, A; TUERLER, H | 1 |
| HUFF, JW; LIEBERT, KV; SPICER, DS; WRIGHT, LD | 1 |
| Akerlund, HE; Andersen, G; Björnberg, O; Compagno, C; Gojković, Z; Hofer, A; Merico, AM; Moritz, T; Møller, K; Piskur, J; Polakova, S; Pynyaha, Y; Rasmussen, A; Sandrini, MP | 1 |
| Fu, L; He, H; Jin, C; Liang, YJ | 1 |
| Couve, S; Gasparutto, D; Ishchenko, AA; Mazouzi, A; Redrejo-Rodríguez, M; Saint-Pierre, C; Saparbaev, M | 1 |
| Brenk, R; Cleghorn, LA; Collie, IT; Frearson, JA; Gilbert, IH; Luksch, T; Mottram, JC; Mpamhanga, C; Norcross, N; Torrie, LS; Walker, RG; Woodland, A; Wyatt, PG | 1 |
| Afantitis, A; Kollias, G; Mavromoustakos, T; Melagraki, G; Mouchlis, VD | 1 |
| Aoki, T; Arai, T; Hayashi, S; Hirokawa, H; Inoue, H; Kainoh, M; Kawai, H; Koga, Y; Meguro, H; Ohno, M; Oshida, K; Suyama, K | 1 |
| Chen, X; He, Y; Wang, F; Wang, J; You, Q; Zhang, Q; Zhou, H | 1 |
| Gong, P; Lin, H; Liu, Z; Wang, L; Wang, Y; Zhao, Y; Zuo, D | 1 |
| Aughey, GN; Liu, JL; Tastan, ÖY | 1 |
| Liu, HM; Ma, LY; Pang, LP; Shao, KP; Wang, B; Wang, SQ; Xue, DQ; Zhang, M; Zheng, YC | 1 |
| Ahmad, F; Hassan, MI; Idrees, D; Kumari, S; Mishra, CB; Prakash, A; Tiwari, M | 1 |
| Butenko, A; Flegontov, P; Lukeš, J; Opperdoes, FR; Yurchenko, V | 1 |
| Chen, ZS; Gupta, P; Lei, ZN; Li, YN; Li, ZH; Liu, HM; Liu, Y; Ma, LY; Wang, B; Wang, JQ; Zhang, XH; Zhao, B; Zhao, YD | 1 |
| Adler, L; Admon, A; Agemy, L; Auslander, N; Barnea, E; Brandis, A; Carmel, N; Carracedo, A; Dimmock, D; Eilam, R; Elhasid, R; Erez, A; Hannenhalli, S; Helbling, D; Itkin, M; Kalaora, S; Karathia, H; Keshet, R; Lee, JS; Levy, R; Malitsky, S; Nagamani, SCS; Pinto, S; Rabinovich, S; Ruppin, E; Samuels, Y; Scherz, A; Silberman, A; Stern-Ginossar, N; Stettner, N; Sun, Q; Unda, M; Weiss, H; Wilson, DM | 1 |
| Seton-Rogers, S | 1 |
| Collins, C; D'Alessandro, A; Daniels, MW; Danis, E; DeGregori, J; Gao, D; Gehrke, S; Paola, JTD; Pham-Danis, C; Rozhok, AI | 1 |
| Burmistrov, V; Butov, GM; D'yachenko, V; Hammock, BD; Karlov, D; Morisseau, C | 1 |
| El-Dash, Y; Gedawy, EM; Kassab, AE | 1 |
| Bhandari, S; Bhargava, SK; Reddy, TS; Reddy, VG; Sakla, AP; Sana, S; Shankaraiah, N; Tokala, R | 1 |
| Chalapathi, PV; Nagalakshmamma, V; Nagaraju, C; Pasala, C; Thyagaraju, K; Umamaheswari, A; Venkataswamy, M | 1 |
| Jaswal, S; Kumar, S; Monga, V; Rulhania, S | 1 |
3 review(s) available for urea and pyrimidine
| Article | Year |
|---|---|
Comparative Metabolism of Free-living Bodo saltans and Parasitic Trypanosomatids.
Topics: Amino Acids; Bacteria; Carbohydrate Metabolism; Coenzymes; Dolichols; Ergosterol; Eukaryota; Folic Acid; Genes, Protozoan; Gluconeogenesis; Glycolysis; Kinetoplastida; Lipid Metabolism; Mevalonic Acid; Microbodies; Mitochondria; Oxidoreductases; Pentose Phosphate Pathway; Peroxisomes; Phospholipids; Polyamines; Protein Prenylation; Protozoan Proteins; Purines; Pyrimidines; Reactive Oxygen Species; Trypanosomatina; Ubiquinone; Urea; Vitamins | 2016 |
Changing mutational patterns.
Topics: Animals; Carbon-Nitrogen Ligases; Humans; Mice; Mutation; Neoplasms; Pyrimidines; Urea | 2018 |
Recent advances in the medicinal chemistry of carbonic anhydrase inhibitors.
Topics: Acetazolamide; Animals; Antineoplastic Agents; Antioxidants; Benzenesulfonamides; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Humans; Indoles; Isatin; Molecular Docking Simulation; Organoselenium Compounds; Oxadiazoles; Protein Binding; Protein Isoforms; Pyrimidines; Structure-Activity Relationship; Sulfonamides; Thiazines; Thiophenes; Urea | 2021 |
29 other study(ies) available for urea and pyrimidine
| Article | Year |
|---|---|
Nitrogen-stimulated orotic acid synthesis and nucleotide imbalance.
Topics: Ammonia; Animals; Carbamyl Phosphate; Cattle; Humans; Liver Neoplasms; Milk; Orotic Acid; Pyrimidines; Rats; Triglycerides; Urea | 1992 |
The glutamine analog acivicin as antipyrimidine. Studies on the interrelationship between pyrimidine and urea synthesis in liver.
Topics: Animals; Antibiotics, Antineoplastic; Carbamyl Phosphate; Cytosol; Female; Isoxazoles; Liver; Mitochondria, Liver; Orotic Acid; Oxazoles; Pyrimidines; Rats; Rats, Inbred Strains; Urea | 1985 |
[Ammonia metabolism of liver of the fetus induced experimental IUGR in rats--in respect of the enzymes in pyrimidin biosynthesis and urea cycle system].
Topics: Ammonia; Animals; Aspartate Carbamoyltransferase; Carbamoyl-Phosphate Synthase (Ammonia); Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Female; Fetal Growth Retardation; Liver; Pregnancy; Pyrimidines; Rats; Urea | 1985 |
Species comparison of the influence of ammonia on orotic acid and urea biosynthesis in liver.
Topics: Ammonia; Animals; Arginine; Cattle; Female; Liver; Male; Mice; Mice, Inbred ICR; Orotic Acid; Pyrimidines; Rats; Rats, Inbred Strains; Sheep; Species Specificity; Swine; Urea; Valine | 1984 |
Nitration of 2-substituted pyrimidine-4,6-diones, structure and reactivity of 5,5-gem-dinitropyrimidine-4,6-diones.
Topics: Crystallography, X-Ray; Magnetic Resonance Spectroscopy; Molecular Conformation; Molecular Structure; Nitrates; Pyrimidines; Temperature; Urea | 2002 |
Excretion of pyrimidine reduction products by the rat.
Topics: Animals; Biological Transport; Body Fluids; Pyrimidines; Rats; Urea; Urine | 1956 |
CYTOTOXICITY OF HYDROXYUREA (NSC-32065) REVERSIBLE BY PYRIMIDINE DEOXYRIBOSIDES IN A MAMMALIAN CELL LINE GROWN IN VITRO.
Topics: Antimetabolites; Cell Line; Cricetinae; Hydroxyurea; In Vitro Techniques; Neoplasms; Neoplasms, Experimental; Nucleosides; Pyrimidine Nucleosides; Pyrimidines; Research; Thymidine; Tissue Culture Techniques; Urea | 1964 |
STUDIES ON THE PYRIMIDINE DERIVATIVES. XXXI. REACTIONS OF ETHYL 2-METHOXY-METHYLENE-3-ETHOXYPROPIONATE WITH UREAS.
Topics: Chemistry, Pharmaceutical; Methane; Propionates; Pyrimidines; Research; Urea | 1964 |
DEOXYRIBOSYL TRANSFER. II. NUCLEOSIDE:PYRIMIDINE DEOXYRIBOSYLTRANSFERASE ACTIVITY OF THREE PARTIALLY PURIFIED THYMIDINE PHOSPHORYLASES.
Topics: Escherichia coli; Glucosyltransferases; Hot Temperature; Hydrogen-Ion Concentration; Liver; Nucleosides; Pyrimidines; Rats; Research; Ribose; Spleen; Thymidine Phosphorylase; Thymine; Urea | 1964 |
STUDIES OF THE NUCLEOTIDE ARRANGEMENT IN DEOXYRIBONUCLEIC ACIDS. IX. SELECTIVE DEGRADATION OF PYRIMIDINE DEOXYRIBONUCLEOTIDES.
Topics: Chemical Phenomena; Chemistry; Cytosine; Deoxyribonucleotides; DNA; Hydrazines; Kinetics; Nucleotides; Pyrazoles; Pyrimidines; Research; Thymine; Urea | 1964 |
Study of ureidosuccinic acid and related compounds in pyrimidine synthesis by Lactobacillus bulgaricus 09.
Topics: Aspartic Acid; Lactobacillus; Orotic Acid; Pyrimidines; Urea | 1952 |
A second pathway to degrade pyrimidine nucleic acid precursors in eukaryotes.
Topics: Eukaryotic Cells; Fungal Proteins; Lactic Acid; Molecular Structure; Mutagenesis, Site-Directed; Nucleic Acid Precursors; Oxygen; Pentosyltransferases; Pyrimidines; Saccharomyces; Uracil; Urea; Uridine | 2008 |
Synthesis and antitumor activity of ureas containing pyrimidinyl group.
Topics: Antineoplastic Agents; Cell Line, Tumor; Humans; Magnetic Resonance Spectroscopy; Pyrimidines; Structure-Activity Relationship; Urea | 2011 |
New insights in the removal of the hydantoins, oxidation product of pyrimidines, via the base excision and nucleotide incision repair pathways.
Topics: Base Sequence; DNA; DNA Glycosylases; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase; HeLa Cells; Humans; Hydantoins; Kinetics; Oligodeoxyribonucleotides; Oxidation-Reduction; Pyrimidines; Thymine; Urea | 2011 |
Identification of inhibitors of the Leishmania cdc2-related protein kinase CRK3.
Topics: Binding Sites; CDC2 Protein Kinase; Computer Simulation; Drug Evaluation, Preclinical; Humans; Leishmania; Leishmaniasis; Protein Kinase Inhibitors; Protein Structure, Tertiary; Protozoan Proteins; Pyrazoles; Pyrimidines; Structure-Activity Relationship; Urea | 2011 |
Molecular modeling on pyrimidine-urea inhibitors of TNF-α production: an integrated approach using a combination of molecular docking, classification techniques, and 3D-QSAR CoMSIA.
Topics: Algorithms; Catalytic Domain; Cell Line; Discriminant Analysis; Humans; Inhibitory Concentration 50; Mitogen-Activated Protein Kinase 14; Models, Molecular; Protein Conformation; Protein Kinase Inhibitors; Pyrimidines; Quantitative Structure-Activity Relationship; Reproducibility of Results; Systems Integration; Tumor Necrosis Factor-alpha; Urea | 2012 |
Design and synthesis of novel p38α MAP kinase inhibitors: discovery of pyrazole-benzyl ureas bearing 2-molpholinopyrimidine moiety.
Topics: Administration, Oral; Animals; Binding Sites; Crystallography, X-Ray; Cytochrome P-450 Enzyme System; Drug Design; Drug Evaluation, Preclinical; Humans; Imidazoles; Lipopolysaccharides; Liver; Mice; Mitogen-Activated Protein Kinase 14; Naphthalenes; Protein Kinase Inhibitors; Protein Structure, Tertiary; Pyrazoles; Pyridines; Pyrimidines; Tumor Necrosis Factor-alpha; Urea | 2012 |
Identification of type II inhibitors targeting BRAF using privileged pharmacophores.
Topics: Animals; Antineoplastic Agents; Binding Sites; Cell Line, Tumor; Cell Survival; Humans; Mice; Molecular Docking Simulation; Mutation; Phenylurea Compounds; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins B-raf; Pyrimidines; Signal Transduction; Structure-Activity Relationship; Urea; Xenograft Model Antitumor Assays | 2014 |
Design, synthesis and biological evaluation of novel thieno[3,2-d]pyrimidine derivatives containing diaryl urea moiety as potent antitumor agents.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Chemistry Techniques, Synthetic; Drug Design; Drug Screening Assays, Antitumor; Humans; Pyrimidines; Structure-Activity Relationship; Urea | 2014 |
Cellular serpents and dreaming spires: new frontiers in arginine and pyrimidine biology.
Topics: Animals; Arginine; Humans; Pyrimidines; Urea | 2014 |
Design and synthesis of novel 1,2,3-triazole-pyrimidine-urea hybrids as potential anticancer agents.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Drug Design; Drug Screening Assays, Antitumor; Humans; Neoplasms; Pyrimidines; Structure-Activity Relationship; Triazoles; Urea | 2015 |
Design and synthesis of a novel class of carbonic anhydrase-IX inhibitor 1-(3-(phenyl/4-fluorophenyl)-7-imino-3H-[1,2,3]triazolo[4,5d]pyrimidin 6(7H)yl)urea.
Topics: Binding Sites; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Catalytic Domain; Drug Design; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; Protein Binding; Pyrimidines; Spectrometry, Fluorescence; Triazoles; Urea | 2016 |
Discovery of 5-Cyano-6-phenylpyrimidin Derivatives Containing an Acylurea Moiety as Orally Bioavailable Reversal Agents against P-Glycoprotein-Mediated Mutidrug Resistance.
Topics: Administration, Oral; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Design; Drug Resistance, Multiple; Gene Expression Regulation, Neoplastic; Humans; Intracellular Space; Models, Molecular; Molecular Docking Simulation; Protein Conformation; Protein Transport; Pyrimidines; Urea | 2018 |
Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures.
Topics: Amino Acid Transport Systems, Basic; Animals; Aspartate Carbamoyltransferase; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Cell Line, Tumor; Dihydroorotase; Female; Genomics; Humans; Metabolomics; Mice; Mice, Inbred C57BL; Mice, SCID; Mitochondrial Membrane Transport Proteins; Neoplasms; Ornithine Carbamoyltransferase; Phosphorylation; Pyrimidines; RNA Interference; RNA, Small Interfering; Sirolimus; TOR Serine-Threonine Kinases; Urea | 2018 |
Urea Cycle Sustains Cellular Energetics upon EGFR Inhibition in EGFR-Mutant NSCLC.
Topics: Carbamoyl-Phosphate Synthase (Ammonia); Carcinoma, Non-Small-Cell Lung; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Respiration; ErbB Receptors; Glycolysis; HEK293 Cells; Humans; Lung Neoplasms; Metabolomics; Mitochondria; Mutation; Prognosis; Pyrimidines; Signal Transduction; Urea | 2019 |
Imidazolidine-2,4,5- and pirimidine-2,4,6-triones - New primary pharmacophore for soluble epoxide hydrolase inhibitors with enhanced water solubility.
Topics: Adamantane; Binding Sites; Catalytic Domain; Enzyme Inhibitors; Epoxide Hydrolases; Humans; Imidazolidines; Inhibitory Concentration 50; Molecular Docking Simulation; Pyrimidines; Solubility; Structure-Activity Relationship; Urea | 2020 |
Novel pyrazolopyrimidine urea derivatives: Synthesis, antiproliferative activity, VEGFR-2 inhibition, and effects on the cell cycle profile.
Topics: Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Structure-Activity Relationship; Urea; Vascular Endothelial Growth Factor Receptor-2 | 2020 |
Exploration of carbamide derived pyrimidine-thioindole conjugates as potential VEGFR-2 inhibitors with anti-angiogenesis effect.
Topics: Angiogenesis Inhibitors; Antineoplastic Agents; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Indoles; Molecular Structure; Neovascularization, Pathologic; Protein Kinase Inhibitors; Pyrimidines; Structure-Activity Relationship; Tumor Cells, Cultured; Urea; Vascular Endothelial Growth Factor Receptor-2 | 2020 |
Design, synthesis, anti-tobacco mosaic viral and molecule docking simulations of urea/thiourea derivatives of 2-(piperazine-1-yl)-pyrimidine and 1-(4-Fluoro/4-Chloro phenyl)-piperazine and 1-(4-Chloro phenyl)-piperazine - A study.
Topics: Antiviral Agents; Dose-Response Relationship, Drug; Drug Design; Microbial Sensitivity Tests; Molecular Docking Simulation; Molecular Structure; Piperazine; Pyrimidines; Structure-Activity Relationship; Tobacco Mosaic Virus; Urea | 2020 |