Compounds > urea

urea and piperazine

urea has been researched along with piperazine in 14 studies

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (21.43)29.6817
2010's6 (42.86)24.3611
2020's5 (35.71)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Dener, JM; Gangloff, AR; Kuo, EY; Newcomb, WS; Putnam, D; Rice, KD; Wang, VR; Wong, M1
Albericio, F; Armand-Ugón, M; El-Faham, A; Esté, JA1
Ahn, K; Beidler, D; Bhattacharya, K; Cravatt, BF; Johnson, DS; Kamtekar, S; Lazerwith, S; Liimatta, M; Long, JZ; McKinney, MK; Mileni, M; Sadagopan, N; Smith, SE; Stevens, RC; Stiff, C; Swaney, S; Van Becelaere, K; Weerapana, E; Zhang, Y1
Dana, M; Luliński, P; Maciejewska, D1
Behnke, CA; Igaki, S; Kawamura, T; Kiyota, Y; Kono, M; Kori, M; Matsumoto, T; Miyazaki, J; Nishimura, A; Oki, H; Shimojo, M1
Aaltonen, N; Häyrinen, J; Käsnänen, H; Korhonen, J; Kuusisto, A; Laitinen, JT; Laitinen, T; Lehtonen, M; Navia-Paldanius, D; Nevalainen, T; Pantsar, T; Pasonen-Seppänen, S; Poso, A; Ribas, CR; Rönkkö, J; Savinainen, JR; Takabe, P1
Fujimoto, S; Imaeda, T; Kawamura, T; Kono, M; Kori, M; Kosugi, Y; Matsui, H; Matsumoto, T; Odani, T; Shimizu, Y; Shimojo, M1
Adam, S; Krishna Reddy, RC; Raju, CN; Rasheed, S; Subba Rao, D; Venkata Rami Reddy, Y1
Chalapathi, PV; Nagalakshmamma, V; Nagaraju, C; Pasala, C; Thyagaraju, K; Umamaheswari, A; Venkataswamy, M1
Baska, F; Bata, I; Bozó, É; Cselenyák, A; Domány-Kovács, K; Kordás, KS; Kurkó, D; Makó, A; Mohácsi, R; Szántó, G1
Gao, M; Hu, J; Qian, H; Qiao, Z; Wang, Q; Wang, Y; Yan, L; Zhang, W; Zhang, Y1
Naga Raju, C; Sumalatha, S; Venkataramaiah, C1
Hao, Q; Li, L; Meng, T; Shang, Y; Shi, J; Wang, J; Wang, M; Yang, G; Yang, K; Zhang, Z1

Other Studies

14 other study(ies) available for urea and piperazine

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Monocharged inhibitors of mast cell tryptase derived from potent and selective dibasic inhibitors.
    Bioorganic & medicinal chemistry letters, 2001, Sep-03, Volume: 11, Issue:17

    Topics: Animals; Arginine; Benzamidines; Binding Sites; Biological Availability; Drug Design; Drug Evaluation, Preclinical; Guanidines; Humans; Molecular Mimicry; Piperazine; Piperazines; Rats; Serine Endopeptidases; Serine Proteinase Inhibitors; Structure-Activity Relationship; Tryptases; Urea

2001
Use of N-methylpiperazine for the preparation of piperazine-based unsymmetrical bis-ureas as anti-HIV agents.
    ChemMedChem, 2008, Volume: 3, Issue:7

    Topics: Anti-HIV Agents; Benzoxazoles; Carbamates; Cell Line; Cell Survival; HIV Protease; HIV Protease Inhibitors; Humans; Lymphocytes; Methylation; Piperazine; Piperazines; Structure-Activity Relationship; Urea

2008
Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain.
    Chemistry & biology, 2009, Apr-24, Volume: 16, Issue:4

    Topics: Amidohydrolases; Animals; Arachidonic Acids; Brain; Crystallography, X-Ray; Endocannabinoids; Enzyme Inhibitors; Humans; Male; Pain; Piperazine; Piperazines; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Structure-Activity Relationship; Urea

2009
Synthesis of homoveratric acid-imprinted polymers and their evaluation as selective separation materials.
    Molecules (Basel, Switzerland), 2011, May-05, Volume: 16, Issue:5

    Topics: Allylamine; Imidazoles; Models, Molecular; Molecular Imprinting; Piperazine; Piperazines; Polymers; Pyridines; Thiourea; Urea; Vanillic Acid

2011
Synthesis, SAR study, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase (FAAH) inhibitors.
    Bioorganic & medicinal chemistry, 2013, Jan-01, Volume: 21, Issue:1

    Topics: Amidohydrolases; Analgesics; Animals; Humans; Mice; Molecular Docking Simulation; Pain; Piperazine; Piperazines; Rats; Structure-Activity Relationship; Thiazoles; Urea

2013
Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase.
    Chemistry & biology, 2013, Mar-21, Volume: 20, Issue:3

    Topics: Animals; Benzodioxoles; Enzyme Inhibitors; HEK293 Cells; Humans; Mice; Monoacylglycerol Lipases; Piperazine; Piperazines; Piperidines; Rats; Substrate Specificity; Triazoles; Urea

2013
Design, synthesis, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase inhibitors.
    Bioorganic & medicinal chemistry, 2014, Feb-15, Volume: 22, Issue:4

    Topics: Administration, Oral; Amidohydrolases; Analgesics; Animals; Brain; Disease Models, Animal; Drug Design; Enzyme Inhibitors; Half-Life; Male; Mice; Mice, Inbred ICR; Pain; Piperazine; Piperazines; Pyridazines; Pyrimidines; Rats; Rats, Sprague-Dawley; Urea

2014
New urea and thiourea derivatives of piperazine doped with febuxostat: synthesis and evaluation of anti-TMV and antimicrobial activities.
    TheScientificWorldJournal, 2013, Volume: 2013

    Topics: Anti-Infective Agents; Antiviral Agents; Bacterial Physiological Phenomena; Febuxostat; Piperazine; Piperazines; Thiazoles; Thiourea; Tobacco Mosaic Virus; Urea

2013
Design, synthesis, anti-tobacco mosaic viral and molecule docking simulations of urea/thiourea derivatives of 2-(piperazine-1-yl)-pyrimidine and 1-(4-Fluoro/4-Chloro phenyl)-piperazine and 1-(4-Chloro phenyl)-piperazine - A study.
    Bioorganic chemistry, 2020, Volume: 102

    Topics: Antiviral Agents; Dose-Response Relationship, Drug; Drug Design; Microbial Sensitivity Tests; Molecular Docking Simulation; Molecular Structure; Piperazine; Pyrimidines; Structure-Activity Relationship; Tobacco Mosaic Virus; Urea

2020
New V1a receptor antagonist. Part 1. Synthesis and SAR development of urea derivatives.
    Bioorganic & medicinal chemistry letters, 2020, 09-15, Volume: 30, Issue:18

    Topics: Antidiuretic Hormone Receptor Antagonists; High-Throughput Screening Assays; Humans; Inhibitory Concentration 50; Piperazine; Protein Binding; Pyridines; Quinolines; Receptors, Vasopressin; Social Behavior Disorders; Structure-Activity Relationship; Urea

2020
Novel piperazine urea derivatives as highly potent transient receptor potential vanilloid 1 (TRPV1) antagonists.
    Bioorganic chemistry, 2021, Volume: 115

    Topics: Analgesics; Animals; Capsaicin; Dose-Response Relationship, Drug; Humans; Male; Molecular Structure; Pain; Piperazine; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; TRPV Cation Channels; Urea

2021
Design, synthesis,
    Journal of biomolecular structure & dynamics, 2023, Volume: 41, Issue:10

    Topics: Anti-Bacterial Agents; Anti-Infective Agents; Antioxidants; Hydrogen Peroxide; Microbial Sensitivity Tests; Piperazine; Structure-Activity Relationship; Thiourea; Urea

2023
Development of indole-2-carbonyl piperazine urea derivatives as selective FAAH inhibitors for efficient treatment of depression and pain.
    Bioorganic chemistry, 2022, Volume: 128

    Topics: Amidohydrolases; Animals; Depression; Endocannabinoids; Enzyme Inhibitors; Heterocyclic Compounds; Humans; Indoles; Monoacylglycerol Lipases; Pain; Piperazine; Rats; Urea

2022