urea has been researched along with pf-477736 in 7 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, XM; Chen, YD; Li, HF; Liu, HC; Lu, S; Lu, T; Ran, T; Yuan, HL | 1 |
| Bryant, C; Massey, AJ; Rawlinson, R | 1 |
| Kwiatkowski, DJ; Liu, Y | 1 |
| Agostinelli, C; Brighenti, E; Casadei, B; Derenzini, E; Ferrari, A; Fuligni, F; Ghelli Luserna Di Rorà, A; Iacobucci, I; Imbrogno, E; Martinelli, G; Pileri, S; Righi, S; Zinzani, PL | 1 |
| Bertoni, F; Carrassa, L; Chilà, R; Damia, G; Kwee, I; Lupi, M; Restelli, V; Rinaldi, A | 1 |
| Alimova, I; Balakrishnan, I; Birks, DK; Davidson, N; Donson, AM; Foreman, NK; Griesinger, AM; Handler, MH; Harris, PS; Mulcahy Levy, JM; Prince, EW; Remke, M; Shah, M; Taylor, MD; Venkataraman, S; Vibhakar, R | 1 |
| Braisted, JC; Chan, DW; Chen, CW; Cheung, ANY; Dai, Z; Kai, Y; Li, J; Li, Y; Li, Z; Liu, SS; Meng, Y; Ngan, HYS; Peng, W; Sun, J; Sun, W; Tzatsos, A; Yung, MMH; Zheng, W; Zhou, W; Zhu, W | 1 |
7 other study(ies) available for urea and pf-477736
| Article | Year |
|---|---|
Structure-based and shape-complemented pharmacophore modeling for the discovery of novel checkpoint kinase 1 inhibitors.
Topics: Benzodiazepinones; Binding Sites; Biocatalysis; Checkpoint Kinase 1; Drug Design; Ligands; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Protein Binding; Protein Kinase Inhibitors; Protein Kinases; Protein Structure, Tertiary; Pyrazoles; Staurosporine; Structure-Activity Relationship; Thiophenes; Urea | 2010 |
Chk1 inhibition as a novel therapeutic strategy for treating triple-negative breast and ovarian cancers.
Topics: Benzodiazepinones; Biomarkers, Tumor; Cell Line, Tumor; Checkpoint Kinase 1; Cisplatin; Deoxycytidine; Drug Synergism; Female; Gemcitabine; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; Indoles; MCF-7 Cells; Ovarian Neoplasms; Protein Kinase Inhibitors; Protein Kinases; Pyrazoles; Pyridones; Thiophenes; Triple Negative Breast Neoplasms; Urea | 2014 |
Combined CDKN1A/TP53 mutation in bladder cancer is a therapeutic target.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Benzodiazepinones; Cell Cycle; Cell Line, Tumor; Checkpoint Kinase 1; Cyclin-Dependent Kinase Inhibitor p21; Deoxycytidine; Drug Synergism; Gemcitabine; Humans; Mice; Mutation; Protein Kinases; Pyrazoles; Thiophenes; Tumor Suppressor Protein p53; Urea; Urinary Bladder Neoplasms; Xenograft Model Antitumor Assays | 2015 |
Constitutive activation of the DNA damage response pathway as a novel therapeutic target in diffuse large B-cell lymphoma.
Topics: Antineoplastic Agents; Apoptosis; Benzodiazepinones; cdc25 Phosphatases; Cell Line, Tumor; Cell Proliferation; Checkpoint Kinase 1; Checkpoint Kinase 2; DNA Damage; Dose-Response Relationship, Drug; Histones; Humans; Lymphoma, Large B-Cell, Diffuse; Molecular Targeted Therapy; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Proto-Oncogene Proteins c-myc; Pyrazoles; Thiophenes; Time Factors; Tumor Cells, Cultured; Urea | 2015 |
Characterization of a mantle cell lymphoma cell line resistant to the Chk1 inhibitor PF-00477736.
Topics: Antineoplastic Agents; Benzodiazepinones; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Checkpoint Kinase 1; Cyclin D1; Dasatinib; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Humans; Lymphoma, Mantle-Cell; Molecular Targeted Therapy; Nuclear Proteins; Protein Kinase Inhibitors; Protein Kinases; Protein-Tyrosine Kinases; Pyrazoles; Pyrimidines; Pyrimidinones; Signal Transduction; src-Family Kinases; Thiophenes; Time Factors; Urea | 2015 |
Checkpoint kinase 1 expression is an adverse prognostic marker and therapeutic target in MYC-driven medulloblastoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzodiazepinones; Biomarkers, Tumor; Cell Survival; Cerebellar Neoplasms; Checkpoint Kinase 1; Cisplatin; Disease-Free Survival; Genes, myc; Humans; Kaplan-Meier Estimate; Medulloblastoma; Prognosis; Pyrazoles; Thiophenes; Urea | 2016 |
DUOXA1-mediated ROS production promotes cisplatin resistance by activating ATR-Chk1 pathway in ovarian cancer.
Topics: Aged; Animals; Antineoplastic Combined Chemotherapy Protocols; Ataxia Telangiectasia Mutated Proteins; Benzodiazepinones; Cell Line, Tumor; Checkpoint Kinase 1; Cisplatin; Drug Resistance, Neoplasm; Female; Humans; Kaplan-Meier Estimate; Membrane Proteins; Mice; Mice, Nude; Middle Aged; Ovarian Neoplasms; Prognosis; Pyrazoles; Reactive Oxygen Species; Signal Transduction; Thiophenes; Urea; Xenograft Model Antitumor Assays | 2018 |