urea has been researched along with pentylenetetrazole in 44 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (56.82) | 18.7374 |
| 1990's | 2 (4.55) | 18.2507 |
| 2000's | 8 (18.18) | 29.6817 |
| 2010's | 9 (20.45) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barckow, D; Kreutz, G; Schirop, T; Streichert, B; Vohland, HW | 1 |
| Georgiev, VP; Petkova, BP | 1 |
| Chiu, SK; Keifer, L; Timberlake, JW | 1 |
| Fakouhi, T; Zirvi, KA | 2 |
| Yaksh, TL; Yamamura, HI | 1 |
| Dar, MS; Fakouhi, T; Zirvi, KA | 1 |
| Barthwal, JP; Chaturvedi, AK; Parmar, SS; Stenberg, VI | 1 |
| Chauhan, SP; Das, M; Ganguly, DK | 1 |
| Millichap, JG | 1 |
| Moffett, RB; Rudzik, AD | 1 |
| Dar, MS; Fakouhi, T | 1 |
| Swinyard, EA | 1 |
| Smith, CM | 1 |
| Auterhoff, H; Lang, W | 1 |
| Watson, WJ; Wood, JD | 1 |
| Hirooka, T; Kadokawa, T; Kobayashi, M; Masuda, Y; Murai, K; Nakamura, H; Nakamura, K; Nakatsuji, K; Senda, H; Soji, Y | 1 |
| Berger, A; Nishie, K; Weary, M | 1 |
| DeFeudis, FV; Elliott, KA | 1 |
| Hirate, J; Ozeki, S; Watanabe, J | 1 |
| Avendaño, MC; Ballesteros, P; Cañadas, S; González, MP | 1 |
| Alexander, GJ; Chatterjie, N | 1 |
| Richards, RK | 1 |
| Chunngam, T; Patarapanich, C; Sooksawate, T; Tantisira, B; Tantisira, MH | 1 |
| Belonga, KL; Carter, DB; Im, HK; Im, WB; Jacobsen, EJ; Mickelson, JW; Petke, JD; Sethy, VH; Stelzer, LS; Tang, AH; TenBrink, RE; VonVoigtlander, PF; Zhong, WZ | 1 |
| Dimmock, JR; Stables, JP; Vashishtha, SC | 1 |
| FUJIMOTO, K; MASUDA, Y; NAKAMURA, K; NAKATSUJI, K; OHASHI, K; OSE, S; TSUTSUI, K | 1 |
| CHUBB, FL; HAJDU, A; KOMLOSSY, J; LEE, CF; MCCOLL, JD | 1 |
| Bialer, M; Sobol, E; Yagen, B | 1 |
| Beleboni, Rde O; Coutinho-Netto, J; Cunha, AO; dos Santos, WF; Gelfuso, EA; Liberato, JL; Mortari, MR | 1 |
| Gütschow, M; Kubacka, M; Librowski, T; Meusel, M; Müller, CE; Scolari, S | 1 |
| Bialer, M; Finnell, RH; Pessah, N; Shimshoni, JA; Wlodarczyk, B; Yagen, B | 1 |
| Bialer, M; Finnell, RH; Schurig, V; Shimshoni, JA; Wlodarczyk, B; Yagen, B | 1 |
| Jain, NK; Kashaw, SK; Kashaw, V; Mishra, P; Stables, JP | 1 |
| Bialer, M; Fujiwara, M; Noyori, H; Okada, A; Shimshoni, JA; Yagen, B | 1 |
| Bialer, M; Devor, M; Kaufmann, D; Shimshoni, JA; Yagen, B | 1 |
| Alam, MS; Siddiqui, N; Stables, JP | 1 |
| Guo, H; He, X; Hu, X; Wu, Z; Xiao, Y; Yang, J; Zhong, M | 1 |
| Beleboni, RO; Cunha, AO; Dos Santos, WF; Gelfuso, EA; Liberato, JL; Lopes, NP; Mortari, MR | 1 |
| Liu, XM; Ni, LY; Song, Y; Tang, JY; Zhu, MJ | 1 |
| Liu, Xm; Ren, Yy; Tang, Jy; Tang, S; Yang, Wx; Zhang, Rx; Zhao, X | 1 |
| Elahdadi Salmani, M; Goudarzi, E; Goudarzi, I; Lashkarbolouki, T | 1 |
| Socała, K; Szuster-Ciesielska, A; Wlaź, P | 1 |
| Asadi, S; Fereidoni, M; Kordi Jaz, E; Moghimi, A; Roohbakhsh, A; Shamsizadeh, A | 1 |
2 review(s) available for urea and pentylenetetrazole
| Article | Year |
|---|---|
Relation of laboratory evaluation to clinical effectiveness of antiepileptic drugs.
Topics: Acetazolamide; Adrenocorticotropic Hormone; Animals; Anticonvulsants; Benzazepines; Clinical Trials as Topic; Drug Tolerance; Electroencephalography; Electroshock; Epilepsy; Ethosuximide; Humans; Pentylenetetrazole; Phenobarbital; Phenytoin; Primidone; Seizures; Trimethadione; Urea | 1969 |
Laboratory evaluation of antiepileptic drugs. Review of laboratory methods.
Topics: Animals; Anticonvulsants; Biological Assay; Brain Injuries; Diagnosis; Electroconvulsive Therapy; Electroshock; Humans; Methionine Sulfoximine; Methods; Pentylenetetrazole; Phenobarbital; Phenytoin; Picrotoxin; Seizures; Strychnine; Thiosemicarbazones; Trimethadione; Urea | 1969 |
1 trial(s) available for urea and pentylenetetrazole
| Article | Year |
|---|---|
Relation of laboratory evaluation to clinical effectiveness of antiepileptic drugs.
Topics: Acetazolamide; Adrenocorticotropic Hormone; Animals; Anticonvulsants; Benzazepines; Clinical Trials as Topic; Drug Tolerance; Electroencephalography; Electroshock; Epilepsy; Ethosuximide; Humans; Pentylenetetrazole; Phenobarbital; Phenytoin; Primidone; Seizures; Trimethadione; Urea | 1969 |
42 other study(ies) available for urea and pentylenetetrazole
| Article | Year |
|---|---|
[On the toxicology of carbromal. III. Role of active metabolites in humans acutely poisoned with carbromal-containing sedatives (author's transl)].
Topics: Adult; Aged; Animals; Biotransformation; Female; Humans; Hypnotics and Sedatives; Lethal Dose 50; Male; Middle Aged; Pentylenetetrazole; Rats; Species Specificity; Time Factors; Urea | 1978 |
Effect of p-chlorophenylalanine on the central nervous excitability threshold and on the activity of some central depressants.
Topics: Animals; Central Nervous System; Depression, Chemical; Fenclonine; Hypnotics and Sedatives; Injections, Intraperitoneal; Injections, Intravenous; Male; Mice; Pentylenetetrazole; Phenobarbital; Phenylacetates; Picrotoxin; Seizures; Strychnine; Time Factors; Toluene; Urea | 1975 |
Synthesis of imidazolidinediones and oxazolidinediones from cyclization of propargylureas and propargyl carbamates.
Topics: Animals; Anticonvulsants; Carbamates; Cyclization; Electroshock; Imidazoles; Methods; Mice; Oxazoles; Pentylenetetrazole; Structure-Activity Relationship; Urea | 1979 |
Synthesis and neuropharmacology of cyclobutanecarbonylureas.
Topics: Animals; Central Nervous System Depressants; Female; Male; Mice; Oxotremorine; Pentylenetetrazole; Phenobarbital; Strychnine; Urea | 1979 |
The release in vivo of [3-H] acetylcholine from cat caudate nucleus and cerebral cortex by atropine, pentylenetetrazol, K-+ -depolarization and electrical stimulation.
Topics: Acetylcholine; Animals; Atropine; Carbon Radioisotopes; Cats; Caudate Nucleus; Cerebellar Cortex; Cerebral Cortex; Choline; Electric Stimulation; Female; Lipid Metabolism; Male; Pentylenetetrazole; Phosphorylcholine; Potassium; Tritium; Urea | 1975 |
Biochemorphology of cyclobutanecarbonylureas.
Topics: Animals; Cyclobutanes; Drug Synergism; Female; Hypnotics and Sedatives; Male; Mice; Muscle Relaxants, Central; Pentobarbital; Pentylenetetrazole; Seizures; Tremorine; Urea | 1975 |
Anticonvulsant activity of N,N'-bis[3-(3-substituted urea)propyl]piperazines.
Topics: Animals; Anticonvulsants; Brain; In Vitro Techniques; Lethal Dose 50; Male; Oxygen Consumption; Pentylenetetrazole; Piperazines; Pyruvates; Rats; Seizures; Urea | 1975 |
Alpha 2-antagonistic effect of N-carbamoyl-2-(2,6-dichlorophenyl) acetamidine hydrochloride (LON-954).
Topics: Adrenergic alpha-Antagonists; Animals; Body Temperature; Clonidine; Dopamine Antagonists; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Myenteric Plexus; Pentylenetetrazole; Rats; Seizures; Urea; Vas Deferens; Yohimbine | 1988 |
Central nervous system depressants. 11. Benzodiazepines with ureas in the 2 position.
Topics: Animals; Behavior, Animal; Benzazepines; Central Nervous System; Depression, Chemical; Drug Synergism; Electroshock; Ethanol; Male; Mice; Mice, Inbred Strains; Motor Activity; Nicotine; Pentylenetetrazole; Structure-Activity Relationship; Strychnine; Thiosemicarbazones; Urea | 1973 |
Studies on some aspects of the neuropharmacology of butylurea.
Topics: Administration, Oral; Analgesics; Animals; Anticonvulsants; Barbiturates; Butanes; Central Nervous System; Depression, Chemical; Dose-Response Relationship, Drug; Drug Synergism; Female; Hypnotics and Sedatives; Injections, Intraperitoneal; Lethal Dose 50; Male; Mice; Pentylenetetrazole; Proadifen; Rats; Seizures; Sleep; Strychnine; Time Factors; Urea | 1974 |
The release of acetylcholine from rabbit hippocampus.
Topics: Acetylcholine; Animals; Carbon Isotopes; Electric Stimulation; Hippocampus; Morphine; Pentylenetetrazole; Rabbits; Urea | 1972 |
[Preparation and properties of optically active bromisovals].
Topics: Animals; Bromides; Bromine; Mice; Parasympatholytics; Pentylenetetrazole; Stereoisomerism; Urea; Valerates | 1970 |
The effect of intraperitoneal injections of hyperosmotic solutions on convulsions induced by drugs and hyperbaric oxygen.
Topics: Aminobutyrates; Animals; Brain Diseases; Dehydration; Glucose; Hyperbaric Oxygenation; Hypertonic Solutions; Injections, Intraperitoneal; Male; Osmolar Concentration; Pentylenetetrazole; Picrotoxin; Rats; Seizures; Semicarbazides; Urea | 1968 |
Neuropharmacological and toxicological studies on a new anti-epileptic, N-alpha-ethyl-phenylacetyl-N'-acetyl urea in experimental animals.
Topics: Alanine Transaminase; Animals; Anticholesteremic Agents; Anticonvulsants; Aspartate Aminotransferases; Blood; Cholesterol; Depression, Chemical; Electroshock; Female; Growth; Male; Mice; Nephrosis; Organ Size; Pentylenetetrazole; Rats; Stimulation, Chemical; Urea | 1968 |
Anticonvulsant and convulsant effects of chemically related thiosemicarbazide, thiourea and urea derivatives.
Topics: Aldehydes; Animals; Anticonvulsants; Electroconvulsive Therapy; Mice; Pentylenetetrazole; Pyridines; Seizures; Semicarbazides; Thiourea; Urea | 1966 |
Delay or inhibition of convulsions by intraperitoneal injections of diverse substances.
Topics: Alanine; Aminobutyrates; Animals; Atmospheric Pressure; Brain Chemistry; Hypertonic Solutions; Injections, Intraperitoneal; Male; Organ Size; Oxygen; Pentylenetetrazole; Picrotoxin; Potassium; Rats; Seizures; Sodium; Sodium Chloride; Strychnine; Succinates; Sucrose; Urea | 1967 |
Effect of convulsions induced by pentylenetetrazole or electricity on the dispositions of creatinine and urea in rats.
Topics: Animals; Creatinine; Electroshock; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Urea | 1984 |
Synthesise and neuropharmacology of butyrylureas.
Topics: Animals; Barbiturates; Butyrates; Central Nervous System Depressants; Chemical Phenomena; Chemistry, Physical; Drug Synergism; Hypnotics and Sedatives; Male; Mice; Muscle Relaxants, Central; Oxotremorine; Pentylenetetrazole; Structure-Activity Relationship; Urea | 1982 |
Effect of diphenylhydantoin, granatane-3-spiro-5'-hydantoin and leptazol on mouse brain glutamate dehydrogenase, urea and ammonia levels in brain.
Topics: Ammonia; Animals; Brain; Drug Interactions; Glutamate Dehydrogenase; Hydantoins; Mice; Mice, Inbred ICR; Pentylenetetrazole; Phenytoin; Urea | 1981 |
Anticonvulsive activity of indenoimidazolidinones and related heterocyclic compounds in mice.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Behavior, Animal; Chemical Phenomena; Chemistry; Dose-Response Relationship, Drug; Heterocyclic Compounds; Imidazoles; Male; Mice; Motor Activity; Ninhydrin; Pentylenetetrazole; Urea | 1980 |
Structure-activity relationships in the effects of phenacemide analogs on serum creatinine and anticonvulsant activity.
Topics: Animals; Anticonvulsants; Benzeneacetamides; Creatinine; Electroshock; Pentylenetetrazole; Phenylacetates; Rabbits; Structure-Activity Relationship; Urea | 1980 |
Preliminary evaluation of the anticonvulsant activity of a valproic acid analog: N-(2-propylpentanoyl) urea.
Topics: Animals; Anticonvulsants; Bicuculline; Central Nervous System; Convulsants; Dose-Response Relationship, Drug; Electroshock; Lethal Dose 50; Male; Mice; Motor Activity; Pentylenetetrazole; Seizures; Sleep; Strychnine; Time Factors; Urea; Valproic Acid | 1997 |
Piperazine imidazo[1,5-a]quinoxaline ureas as high-affinity GABAA ligands of dual functionality.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Biological Availability; Cell Line; Cerebellum; Convulsants; Cyclic GMP; Drug Evaluation, Preclinical; GABA Agonists; Imidazoles; In Vitro Techniques; Ligands; Male; Mice; Models, Molecular; Molecular Conformation; Pentylenetetrazole; Piperazines; Quinoxalines; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Structure-Activity Relationship; Urea | 1999 |
Ureylene anticonvulsants and related compounds.
Topics: Animals; Anticonvulsants; Convulsants; Electroshock; Male; Mice; Models, Molecular; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures; Structure-Activity Relationship; Urea | 2000 |
THE ANTICONVULSANT ACTIVITY OF ETHYL ALPHA-PHENYLBUTYROYL ALLOPHANATE (P-5257).
Topics: Anticonvulsants; Barbiturates; Carbamates; Central Nervous System; Mice; Pentylenetetrazole; Pharmacology; Rats; Research; Seizures; Toxicology; Urea | 1963 |
SYNTHESIS AND PHARMACOLOGICAL PROPERTIES OF PHENYL-SUBSTITUTED BIURETS.
Topics: Atropine; Biuret; Chemistry, Pharmaceutical; Gastric Juice; Meprobamate; Mice; Nicotine; Pentylenetetrazole; Peptic Ulcer; Pharmacology; Phenformin; Phenobarbital; Picrotoxin; Rats; Research; Seizures; Strychnine; Toxicology; Urea | 1963 |
Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives.
Topics: Animals; Anticonvulsants; Convulsants; Cyclopropanes; Electroshock; Mice; Pentylenetetrazole; Polyunsaturated Alkamides; Rats; Seizures; Species Specificity; Structure-Activity Relationship; Urea; Valproic Acid | 2004 |
Anticonvulsant and anxiolytic activity of FrPbAII, a novel GABA uptake inhibitor isolated from the venom of the social spider Parawixia bistriata (Araneidae: Araneae).
Topics: Analysis of Variance; Animals; Anticonvulsants; Anxiety; Behavior, Animal; Bicuculline; Choice Behavior; Diazepam; Disease Models, Animal; Drug Interactions; Hippocampus; Male; Maze Learning; Neuroprotective Agents; Nipecotic Acids; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Spider Venoms; Spiders; Substantia Nigra; Urea | 2006 |
Evaluation of anticonvulsant and analgesic effects of benzyl- and benzhydryl ureides.
Topics: Analgesics; Animals; Anticonvulsants; Benzhydryl Compounds; Benzyl Compounds; Binding, Competitive; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Hot Temperature; Male; Mice; Molecular Structure; Motor Activity; Pain Measurement; Pain Threshold; Pentylenetetrazole; Picrotoxin; Receptors, GABA-A; Receptors, Purinergic P1; Seizures; Structure-Activity Relationship; Urea | 2007 |
Anticonvulsant profile and teratogenicity of 3,3-dimethylbutanoylurea: a potential for a second generation drug to valproic acid.
Topics: Animals; Anticonvulsants; Behavior, Animal; Electrodes, Implanted; Half-Life; Hippocampus; Kindling, Neurologic; Male; Mice; Neural Tube Defects; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Teratogens; Urea; Valproic Acid | 2008 |
Evaluation of stereoselective anticonvulsant, teratogenic, and pharmacokinetic profile of valnoctylurea (capuride): a chiral stereoisomer of valproic acid urea derivative.
Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Female; Half-Life; Male; Mice; Neural Tube Defects; Pentanoic Acids; Pentylenetetrazole; Pregnancy; Rats; Rats, Sprague-Dawley; Seizures; Stereoisomerism; Structure-Activity Relationship; Teratogens; Urea; Valproic Acid | 2010 |
Synthesis, anticonvulsant and CNS depressant activity of some new bioactive 1-(4-substituted-phenyl)-3-(4-oxo-2-phenyl/ethyl-4H-quinazolin-3-yl)-urea.
Topics: Animals; Anticonvulsants; Behavior, Animal; Central Nervous System Depressants; Male; Mice; Molecular Structure; Pentylenetetrazole; Quinazolinones; Rats; Rats, Sprague-Dawley; Rats, Wistar; Seizures; Structure-Activity Relationship; Urea | 2009 |
Anticonvulsant profile and teratogenic evaluation of potent new analogues of a valproic acid urea derivative in NMRI mice.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Bone and Bones; Deep Sedation; Differential Threshold; Electric Stimulation; Electroshock; Female; Fetal Death; Mice; Mice, Inbred Strains; Motor Activity; Neural Tube Defects; Pentylenetetrazole; Pregnancy; Rats; Rats, Sprague-Dawley; Seizures; Structure-Activity Relationship; Teratogens; Urea; Valproic Acid | 2009 |
Synthesis and evaluation of antiallodynic and anticonvulsant activity of novel amide and urea derivatives of valproic acid analogues.
Topics: Amides; Animals; Anticonvulsants; Electroshock; Isomerism; Male; Mice; Pain; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures; Spinal Nerves; Urea; Valproic Acid | 2009 |
Synthesis and anticonvulsant properties of 1-(amino-N-arylmethanethio)-3-(1-substituted benzyl-2, 3-dioxoindolin-5-yl) urea derivatives.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Electroshock; Mice; Molecular Structure; Pentylenetetrazole; Rats; Seizures; Stereoisomerism; Structure-Activity Relationship; Urea | 2011 |
Synthesis and anticonvulsant activity of 1-(2-(8-(benzyloxy)quinolin-2-yl)-1-butyrylcyclopropyl)-3-substituted urea derivatives.
Topics: Animals; Anticonvulsants; Convulsants; Electroshock; Male; Mice; Pentylenetetrazole; Quinolines; Seizures; Urea | 2012 |
Parawixin2, a novel non-selective GABA uptake inhibitor from Parawixia bistriata spider venom, inhibits pentylenetetrazole-induced chemical kindling in rats.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Dose-Response Relationship, Drug; GABA Uptake Inhibitors; Kindling, Neurologic; Male; Nipecotic Acids; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Spider Venoms; Urea | 2013 |
Pentylenetetrazol-induced seizures are exacerbated by sleep deprivation through orexin receptor-mediated hippocampal cell proliferation.
Topics: Animals; Benzoxazoles; CA3 Region, Hippocampal; Cell Proliferation; Convulsants; Dentate Gyrus; Hippocampus; Intracellular Signaling Peptides and Proteins; Isoquinolines; Male; Naphthyridines; Neurons; Neuropeptides; Neuroprotective Agents; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Pentylenetetrazole; Pyridines; Rats; Rats, Wistar; Seizures; Sleep Deprivation; Time Factors; Urea | 2014 |
Orexin-A-induced ERK1/2 activation reverses impaired spatial learning and memory in pentylenetetrazol-kindled rats via OX1R-mediated hippocampal neurogenesis.
Topics: Animals; Benzoxazoles; Doublecortin Protein; Enzyme Activation; Hippocampus; Intracellular Signaling Peptides and Proteins; Male; Maze Learning; Memory; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Naphthyridines; Neurogenesis; Neuropeptides; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Pentylenetetrazole; Rats, Wistar; Spatial Learning; Urea | 2014 |
Hippocampal orexin receptors inactivation reduces PTZ induced seizures of male rats.
Topics: Animals; Benzoxazoles; Convulsants; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Isoquinolines; Male; Microinjections; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Pentylenetetrazole; Pyridines; Rats; Seizures; Urea | 2015 |
SB 334867, a selective orexin receptor type 1 antagonist, elevates seizure threshold in mice.
Topics: Animals; Anticonvulsants; Benzoxazoles; Brain Chemistry; Convulsants; Electroshock; Male; Mice; Muscle Strength; Myoclonus; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Pentylenetetrazole; Psychomotor Performance; Seizures; Urea | 2016 |
SB-334867, an orexin receptor 1 antagonist, decreased seizure and anxiety in pentylenetetrazol-kindled rats.
Topics: Animals; Anxiety; Benzoxazoles; Dose-Response Relationship, Drug; Kindling, Neurologic; Male; Maze Learning; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Urea | 2017 |