Compounds > urea

urea and miv 150

urea has been researched along with miv 150 in 24 studies

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (16.67)29.6817
2010's19 (79.17)24.3611
2020's1 (4.17)2.80

Authors

AuthorsStudies
Danielson, UH; Geitmann, M; Unge, T1
Buckheit, RW; Fernández-Romero, JA; Hartman, TL; Li, J; Maguire, RA; Miller, T; Phillips, DM; Robbiani, M; Sudol, K; Thorn, M; Titchen, K; Turville, SG1
Danielson, UH; Geitmann, M1
Akpogheneta, OJ; Aravantinou, M; Blanchard, J; Chudolij, A; Crostarosa, F; Gettie, A; Hu, L; Jasny, E; Kenney, J; Lifson, JD; Piatak, M; Robbiani, M; Shaw, A; Teitelbaum, A; Zydowsky, TM1
Abraham, CJ; Aravantinou, M; Blanchard, J; Chudolij, A; Fernández-Romero, JA; Gettie, A; Hsu, M; Kenney, J; Kizima, L; Lifson, JD; Menon, R; Piatak, M; Robbiani, M; Rodriguez, A; Seidor, S; Singer, R; Zydowsky, TM1
Kaptur, PE; Mertenskoetter, T1
Aravantinou, M; Blanchard, J; Chudolij, A; Derby, N; Fernández-Romero, JA; Gettie, A; Kenney, J; Kizima, L; Lifson, JD; Piatak, M; Robbiani, M; Rodriguez, A; Singer, R; Zydowsky, TM1
Abraham, CJ; Aravantinou, M; Blanchard, J; Derby, N; Fernández-Romero, JA; Gettie, A; Kenney, J; Lifson, JD; Menon, R; Piatak, M; Robbiani, M; Seidor, S; Singer, R; Zhang, S; Zydowsky, TM1
Abraham, CJ; Aravantinou, M; Blanchard, J; Calenda, G; Derby, N; Fernández-Romero, JA; Gettie, A; Goldman, D; Kenney, J; Lifson, JD; Mawson, P; Menon, R; Piatak, M; Robbiani, M; Seidor, S; Singer, R; Teleshova, N; Villegas, G; Zydowsky, TM1
Aravantinou, M; Blanchard, J; Derby, N; Fernández-Romero, JA; Gettie, A; Goldman, D; Kenney, J; Kizima, L; Lifson, JD; Mawson, P; Menon, R; Piatak, M; Robbiani, M; Rodriguez, A; Seidor, S; Singer, R; Zydowsky, TM1
Abraham, CJ; Aravantinou, M; Blanchard, J; Derby, N; Fernández-Romero, JA; Gettie, A; Grasperge, B; Hsu, M; Jean-Pierre, N; Keele, BF; Kizima, L; Krawczyk, N; Lifson, JD; Mizenina, O; Piatak, MJ; Robbiani, M; Rodriguez, A; Seidor, S; Zhang, S; Zydowsky, TM1
Barnable, P; Blanchard, J; Cooney, ML; Fernández-Romero, JA; Gettie, A; Kizima, L; Mawson, P; Ouattara, LA; Robbiani, M; Roberts, KD; Rodriguez, A; Seidor, S; Teleshova, N; Zydowsky, TM1
Blanchard, J; Derby, N; Fernández-Romero, JA; Ford, BE; Gettie, A; Jean-Pierre, N; Kenney, J; Kizima, L; Levendosky, K; Lifson, JD; Menon, R; Mizenina, O; Paglini, G; Piatak, M; Pugach, P; Robbiani, M; Rodríguez, A; Seidor, S; Teleshova, N; Villegas, G; Zhang, S; Zydowsky, TM1
Abraham, C; Barnable, P; Blanchard, J; Calenda, G; Cooney, ML; Fernandez-Romero, JA; Gettie, A; Jean-Pierre, N; Kizima, L; Lifson, JD; Menon, R; Ouattara, L; Piatak, M; Robbiani, M; Roberts, KD; Rodríguez, A; Seidor, S; Sperling, R; Teleshova, N; Zydowsky, TM1
Barnable, P; Blanchard, J; Bonnaire, T; Calenda, G; Cooney, ML; Fernández-Romero, JA; Gettie, A; Levendosky, K; Menon, R; Teleshova, N; Zydowsky, TM1
Aravantinou, M; Blanchard, J; Derby, N; Fernández-Romero, JA; Gettie, A; Grasperge, B; Kenney, J; Kizima, L; Kumar, N; Levendosky, K; Mizenina, O; Robbiani, M; Roberts, K; Rodriguez, A; Seidor, S; Ugaonkar, SR; Wesenberg, A; Wilk, J; Zhang, S; Zydowsky, TM1
Barnable, P; Clark, MR; Cooney, ML; Doncel, GF; Fernández-Romero, JA; Jean-Pierre, N; Kizima, L; Robbiani, M; Rodríguez, A; Seidor, S; Teleshova, N; Zydowsky, TM1
Calenda, G; Cooney, ML; Creasy, GW; Fernández-Romero, JA; Friedland, B; Hoesley, CJ; Kleinbeck, K; Mizenina, O; Teleshova, N; Villegas, G; Zhang, S; Zydowsky, TM1
Blanchard, J; Calenda, G; Cooney, ML; Fernández-Romero, JA; Gettie, A; Kizima, L; Mizenina, O; Robbiani, M; Teleshova, N; Ugaonkar, S; Villegas, G; Zhang, S; Zydowsky, TM1
Alami, M; Creasy, GW; Fernández-Romero, JA; Friedland, BA; Hoesley, CJ; Hoskin, E; Katzen, LL; Kleinbeck, KR; Novak, L; Plagianos, M; Teleshova, N; Zhang, S; Zydowsky, TM1
Barnable, P; Blanchard, J; Calenda, G; Cooney, ML; Fernández-Romero, JA; Gettie, A; Levendosky, K; Litterst, C; Teleshova, N; Villegas, G; Zydowsky, TM1
Giacobbi, NS; Sluis-Cremer, N1
Aravantinou, M; Blanchard, J; Cooney, ML; Derby, N; Fernández-Romero, J; Gettie, A; Grasperge, B; Kenney, J; Kizima, L; Levendosky, K; Lifson, JD; Mizenina, O; Piatak, M; Robbiani, M; Rodriguez, A; Seidor, S; Ugaonkar, SR; Wesenberg, A; Wilk, J; Zhang, S; Zydowsky, TM1
Azeem, SM; Frey, KM; Muwonge, AN; Tabassum, T1

Reviews

1 review(s) available for urea and miv 150

ArticleYear
Update on microbicide research and development - seeking new HIV prevention tools for women.
    European journal of medical research, 2011, Jan-27, Volume: 16, Issue:1

    Topics: Adenine; Administration, Intravaginal; Adult; Africa South of the Sahara; Anti-HIV Agents; Anti-Infective Agents; Clinical Trials as Topic; Cyclohexanes; Drug Discovery; Female; HIV Infections; Humans; Male; Maraviroc; Organophosphonates; Pyridines; Pyrimidines; Tenofovir; Triazoles; Urea

2011

Trials

2 trial(s) available for urea and miv 150

ArticleYear
In Vitro Exposure to PC-1005 and Cervicovaginal Lavage Fluid from Women Vaginally Administered PC-1005 Inhibits HIV-1 and HSV-2 Infection in Human Cervical Mucosa.
    Antimicrobial agents and chemotherapy, 2016, Volume: 60, Issue:9

    Topics: Administration, Intravaginal; Anti-Infective Agents; Body Fluids; Coinfection; Female; Gels; Herpes Genitalis; Herpesvirus 2, Human; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Mucous Membrane; Pyridines; Urea; Vagina; Zinc Acetate

2016
First-in-Human Trial of MIV-150 and Zinc Acetate Coformulated in a Carrageenan Gel: Safety, Pharmacokinetics, Acceptability, Adherence, and Pharmacodynamics.
    Journal of acquired immune deficiency syndromes (1999), 2016, Dec-15, Volume: 73, Issue:5

    Topics: Administration, Intravaginal; Adult; Antiviral Agents; Carrageenan; Chromatography, Liquid; Double-Blind Method; Female; Gels; Humans; Medication Adherence; Patient Acceptance of Health Care; Placebos; Pre-Exposure Prophylaxis; Pyridines; Sexually Transmitted Diseases, Viral; Tandem Mass Spectrometry; Urea; Young Adult; Zinc Acetate

2016

Other Studies

21 other study(ies) available for urea and miv 150

ArticleYear
Biosensor-based kinetic characterization of the interaction between HIV-1 reverse transcriptase and non-nucleoside inhibitors.
    Journal of medicinal chemistry, 2006, Apr-20, Volume: 49, Issue:8

    Topics: Alkynes; Benzoxazines; Binding Sites; Biosensing Techniques; Cyclopropanes; Delavirdine; Enzyme Activation; HIV Reverse Transcriptase; Kinetics; Molecular Structure; Nevirapine; Oxazines; Protein Conformation; Pyridines; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Time Factors; Urea

2006
Carrageenan/MIV-150 (PC-815), a combination microbicide.
    Sexually transmitted diseases, 2007, Volume: 34, Issue:1

    Topics: Anti-Infective Agents; Carrageenan; Chondrus; Drug Therapy, Combination; HIV Infections; HIV-1; HIV-2; Humans; Male; Microbial Sensitivity Tests; Phytotherapy; Pyridines; Reverse Transcriptase Inhibitors; Semen; Urea

2007
Additional level of information about complex interaction between non-nucleoside inhibitor and HIV-1 reverse transcriptase using biosensor-based thermodynamic analysis.
    Bioorganic & medicinal chemistry, 2007, Dec-01, Volume: 15, Issue:23

    Topics: Binding Sites; Biosensing Techniques; HIV Reverse Transcriptase; Kinetics; Molecular Structure; Pyridines; Reverse Transcriptase Inhibitors; Stereoisomerism; Structure-Activity Relationship; Temperature; Thermodynamics; Time Factors; Urea

2007
A macaque model to study vaginal HSV-2/immunodeficiency virus co-infection and the impact of HSV-2 on microbicide efficacy.
    PloS one, 2009, Nov-30, Volume: 4, Issue:11

    Topics: Animals; Anti-Infective Agents; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Chlorocebus aethiops; Cytokines; Enzyme-Linked Immunosorbent Assay; Female; Herpes Simplex; Herpesvirus 2, Human; HIV; HIV Infections; Interferon-gamma; Macaca; Pyridines; Urea; Vero Cells

2009
An antiretroviral/zinc combination gel provides 24 hours of complete protection against vaginal SHIV infection in macaques.
    PloS one, 2011, Jan-05, Volume: 6, Issue:1

    Topics: Administration, Intravaginal; Animals; Anti-Retroviral Agents; Drug Combinations; Female; Gels; HIV Reverse Transcriptase; Humans; Macaca; Pyridines; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Treatment Outcome; Urea; Zinc Acetate

2011
The nonnucleoside reverse transcriptase inhibitor MIV-150 in carrageenan gel prevents rectal transmission of simian/human immunodeficiency virus infection in macaques.
    Journal of virology, 2011, Volume: 85, Issue:11

    Topics: Administration, Rectal; Animals; Anti-Infective Agents, Local; B-Lymphocytes; Carrageenan; Gels; Macaca mulatta; Placebos; Plasma; Pyridines; RNA, Viral; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; T-Lymphocytes; Urea

2011
A single dose of a MIV-150/Zinc acetate gel provides 24 h of protection against vaginal simian human immunodeficiency virus reverse transcriptase infection, with more limited protection rectally 8-24 h after gel use.
    AIDS research and human retroviruses, 2012, Volume: 28, Issue:11

    Topics: Administration, Intravaginal; Administration, Rectal; Animals; Anti-Infective Agents; Female; Herpes Genitalis; Herpesvirus 2, Human; Humans; Pyridines; Rectum; RNA-Directed DNA Polymerase; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Time Factors; Treatment Outcome; Urea; Vagina; Vaginal Creams, Foams, and Jellies; Zinc Acetate

2012
The nonnucleoside reverse transcription inhibitor MIV-160 delivered from an intravaginal ring, but not from a carrageenan gel, protects against simian/human immunodeficiency virus-RT Infection.
    AIDS research and human retroviruses, 2012, Volume: 28, Issue:11

    Topics: Administration, Intravaginal; Administration, Rectal; Animals; Carrageenan; Enzyme Inhibitors; Female; HIV Reverse Transcriptase; Humans; Macaca mulatta; Pyridines; Rectum; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Thiazoles; Thiourea; Treatment Outcome; Urea; Vagina

2012
An intravaginal ring that releases the NNRTI MIV-150 reduces SHIV transmission in macaques.
    Science translational medicine, 2012, Sep-05, Volume: 4, Issue:150

    Topics: Administration, Intravaginal; Animals; Contraceptive Devices, Female; Female; Inhibitory Concentration 50; Macaca; Nucleosides; Polyvinyls; Pyridines; Reverse Transcriptase Inhibitors; Silicones; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Urea

2012
Exposure to MIV-150 from a high-dose intravaginal ring results in limited emergence of drug resistance mutations in SHIV-RT infected rhesus macaques.
    PloS one, 2014, Volume: 9, Issue:2

    Topics: Administration, Intravaginal; Animals; Anti-Infective Agents, Local; Drug Resistance, Viral; Female; Injections, Intramuscular; Macaca mulatta; Mutation; Pyridines; Reverse Transcriptase Inhibitors; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Time Factors; Urea; Viral Load

2014
MIV-150-containing intravaginal rings protect macaque vaginal explants against SHIV-RT infection.
    Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:5

    Topics: Administration, Intravaginal; Animals; Female; Macaca; Pyridines; Reverse Transcriptase Inhibitors; Simian Acquired Immunodeficiency Syndrome; Urea

2014
A potent combination microbicide that targets SHIV-RT, HSV-2 and HPV.
    PloS one, 2014, Volume: 9, Issue:4

    Topics: Alphapapillomavirus; Anal Canal; Animals; Anti-Infective Agents; Caco-2 Cells; Carrageenan; Female; Gels; HeLa Cells; Herpes Simplex; Herpesvirus 2, Human; Host-Pathogen Interactions; Humans; Macaca mulatta; Mice, Inbred BALB C; Papillomavirus Infections; Pyridines; Rectum; Reverse Transcriptase Inhibitors; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Treatment Outcome; Urea; Vagina; Zinc Acetate

2014
A MIV-150/zinc acetate gel inhibits SHIV-RT infection in macaque vaginal explants.
    PloS one, 2014, Volume: 9, Issue:9

    Topics: Administration, Intravaginal; Animals; Anti-HIV Agents; Carrageenan; Chemistry, Pharmaceutical; Female; Gels; Humans; Macaca mulatta; Mucous Membrane; Pyridines; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tissue Culture Techniques; Urea; Vagina; Virus Replication; Zinc Acetate

2014
MIV-150/zinc acetate gel inhibits cell-associated simian-human immunodeficiency virus reverse transcriptase infection in a macaque vaginal explant model.
    Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:7

    Topics: Administration, Intravaginal; Animals; Antiviral Agents; Cervix Uteri; Female; HIV Reverse Transcriptase; HIV-1; Macaca mulatta; Monkey Diseases; Mucous Membrane; Pyridines; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Urea; Vaginal Creams, Foams, and Jellies; Zinc Acetate

2015
A novel intravaginal ring to prevent HIV-1, HSV-2, HPV, and unintended pregnancy.
    Journal of controlled release : official journal of the Controlled Release Society, 2015, Sep-10, Volume: 213

    Topics: Administration, Intravaginal; Animals; Antiviral Agents; Carrageenan; Cell Line; Contraceptive Agents, Female; Contraceptive Devices, Female; Drug Delivery Systems; Equipment Design; Female; HeLa Cells; Herpes Genitalis; Herpesvirus 2, Human; HIV Infections; HIV Reverse Transcriptase; HIV-1; Human papillomavirus 16; Humans; Levonorgestrel; Macaca mulatta; Papillomavirus Infections; Pregnancy; Pyridines; Urea; Zinc Acetate

2015
Multipurpose Prevention Approaches with Antiretroviral-Based Formulations.
    Antimicrobial agents and chemotherapy, 2016, Volume: 60, Issue:2

    Topics: Administration, Intravaginal; Animals; Anti-Retroviral Agents; Carrageenan; Drug Combinations; Female; Gels; Herpesvirus 2, Human; HIV-1; Macaca mulatta; Mice, Inbred BALB C; Pyridines; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Urea; Vagina; Zinc Acetate

2016
A Novel Microbicide/Contraceptive Intravaginal Ring Protects Macaque Genital Mucosa against SHIV-RT Infection Ex Vivo.
    PloS one, 2016, Volume: 11, Issue:7

    Topics: Animals; Anti-Infective Agents; Carrageenan; Contraceptive Agents, Female; Contraceptive Devices, Female; Drug Combinations; Female; HIV; Levonorgestrel; Macaca mulatta; Mucous Membrane; Pyridines; Reassortant Viruses; Reverse Transcriptase Inhibitors; Simian Immunodeficiency Virus; Treatment Outcome; Urea; Vagina; Zinc Acetate

2016
MZC Gel Inhibits SHIV-RT and HSV-2 in Macaque Vaginal Mucosa and SHIV-RT in Rectal Mucosa.
    Journal of acquired immune deficiency syndromes (1999), 2017, 03-01, Volume: 74, Issue:3

    Topics: Animals; Antiviral Agents; Female; Gels; Herpesvirus 2, Human; Macaca; Microbial Sensitivity Tests; Models, Theoretical; Mucous Membrane; Organ Culture Techniques; Pyridines; Rectum; RNA-Directed DNA Polymerase; Simian Immunodeficiency Virus; Urea; Vagina

2017
    Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:7

    Topics: Anti-HIV Agents; Drug Resistance, Viral; HIV Infections; Humans; Pyridines; Pyrimidines; Reproductive Tract Infections; Reverse Transcriptase Inhibitors; Rilpivirine; Urea

2017
An intravaginal ring that releases three antiviral agents and a contraceptive blocks SHIV-RT infection, reduces HSV-2 shedding, and suppresses hormonal cycling in rhesus macaques.
    Drug delivery and translational research, 2017, Volume: 7, Issue:6

    Topics: Alphapapillomavirus; Animals; Antiviral Agents; Carrageenan; Contraceptive Agents, Female; Contraceptive Devices, Female; Disease Models, Animal; Drug Therapy, Combination; Female; Herpes Simplex; Herpesvirus 2, Human; Humans; Macaca mulatta; Menstrual Cycle; Pyridines; Simian Acquired Immunodeficiency Syndrome; Urea; Vaginal Creams, Foams, and Jellies; Virus Shedding; Zinc Acetate

2017
Application of Structure-based Methods to Analyze Resistance Mutations for Chemically Diverse Non-Nucleoside Reverse Transcriptase Inhibitors.
    Current HIV research, 2020, Volume: 18, Issue:4

    Topics: Allosteric Site; Anti-HIV Agents; Binding Sites; Drug Resistance, Viral; Enzyme Assays; Gene Expression; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Kinetics; Molecular Docking Simulation; Molecular Dynamics Simulation; Mutation; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Pyridines; Pyridones; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Thermodynamics; Triazoles; Urea

2020