urea has been researched along with methotrexate in 73 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 46 (63.01) | 18.7374 |
| 1990's | 6 (8.22) | 18.2507 |
| 2000's | 6 (8.22) | 29.6817 |
| 2010's | 12 (16.44) | 24.3611 |
| 2020's | 3 (4.11) | 2.80 |
| Authors | Studies |
|---|---|
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Blakley, RL; Cocco, L; London, RE; Matwiyoff, NA; Walker, TE | 1 |
| Dunlap, RB; Reinsch, JW; Smith, LL | 1 |
| Gelfand, MC; Knepshield, JH; Schreiner, GE; Winchester, JF | 1 |
| Blake, DA; Burnett, LS; Conner, EA; King, TM; Parmley, TH | 1 |
| Czyzewska, K; Knapowski, J | 1 |
| Aherne, GW; Arendt, J; English, J; Marks, V | 1 |
| Webber, S; Whiteley, JM | 1 |
| Dunlap, RB; Liu, JK | 1 |
| Kaplan, NO; Kisliuk, RL; Pastore, EJ; Plante, LT; Wright, JM | 1 |
| Baugh, CM; Krumdieck, CL; Nair, MG | 1 |
| Shapiro, WR | 1 |
| Beare, JM | 1 |
| Hoshino, T; Wilson, CB | 1 |
| Hakala, MT | 1 |
| Crosby, LK; Kozloff, LM; Lute, M; Verses, C | 1 |
| Bachur, NR; Jarabak, J | 1 |
| Dunlap, RB; Freisheim, JH; Gundersen, LE; Harding, NG; Huennekens, FM; Otting, F | 1 |
| Bertino, JR; McCullough, JL | 1 |
| Bloom, HJ; Freeman, JE; Hall, RR; Nawrocki, A; Wallace, DM | 1 |
| Artis, EW; Gang, M; Goldin, A; Kline, I; Tyrer, DD; Venditti, JM | 1 |
| Gauldie, J; Hillcoat, BL; Marshall, L | 1 |
| Boyd, TH; Cox, BJ; Komp, DM; Lyles, RL; Stoner, GE | 1 |
| Dano, K; Nissen, NI | 1 |
| Goldin, A | 1 |
| Burns, BC; Rutledge, F; Smith, JP; Soffar, S | 1 |
| Hunt, DE; Pittillo, RF | 1 |
| Donaldson, MH; Gehan, EA; Haggard, ME; Krall, JM; Sullivan, MP; Vietti, TJ | 1 |
| Zubrod, CG | 1 |
| Djerassi, I | 1 |
| Holland, JF | 1 |
| Gorgun, B; Watne, AL | 1 |
| Henderson, ES | 1 |
| Ausman, JI; Rall, DP; Shapiro, WR | 1 |
| Brown, CH; Carbone, PP | 1 |
| Blakley, RL; Nixon, PF | 1 |
| Goldin, A; Kline, I; Tyrer, DD; Venditti, JM | 1 |
| Cohen, LS; Roseman, J; Schweitzer, JL; Studzinski, GP | 1 |
| Brodoff, BB; Daunas, JA; Lemberg, A; Penhos, JC; Sodero, EC; White, R | 1 |
| Clifford, P; Klein, G; Singh, S; Stjernswärd, J | 1 |
| Skipper, HE | 1 |
| Frei, E | 1 |
| Aherne, GW; English, J; Marks, V | 1 |
| Frieden, C; Hoeltzli, SD | 1 |
| Falzone, CJ; Iwakura, M; Jones, BE; Matthews, CR | 1 |
| Finn, BE; Jennings, PA; Jones, BE; Matthews, CR | 1 |
| Audus, KL; Avery, M; Liu, F; Shi, F; Soares, MJ; Zhang, X | 1 |
| Lill, R; Mayer, A; Neupert, W; Rapaport, D | 1 |
| Ahting, U; Dembowski, M; Künkele, KP; Lill, R; Nargang, FE; Neupert, W; Rapaport, D | 1 |
| Matthews, CR; Smith, VF | 1 |
| Robert Matthews, C; Wallace, LA | 1 |
| Asanuma, Y; Kato, M; Kawai, S; Nagai, K; Sugiura, H | 1 |
| Matthews, CR; O'Neill, JC; Svensson, AK | 1 |
| ALEXANDRE, GP; DAMMIN, GJ; MURRAY, JE; NOLAN, B | 1 |
| HUENNEKENS, FM; SCHRECKER, AW | 1 |
| DIXON, GJ; SCHABEL, FM; SELLERS, SM; SIDWELL, RW | 1 |
| Burge, S; Grills, C | 1 |
| Armstrong, S; Avery, AJ; Boyd, M; Cantrill, JA; Cresswell, K; Eden, M; Elliott, RA; Franklin, M; Howard, R; Kendrick, D; Morris, CJ; Prescott, RJ; Putman, K; Rodgers, S; Sheikh, A; Swanwick, G | 1 |
| Goto, M; Kamiya, N; Yang, F | 1 |
| Ates, B; Cetin, A; Otlu, A; Parlakpinar, H; Vardi, N | 1 |
| Huang, B; Joice, M; Kotlyar, A; Otis, J; Thomas, TP | 1 |
| Huang, BH; Kar, S; Lee, CR; Tai, Y; Wu, KW | 1 |
| Ahmed, W; Nabil, T; Zaki, A | 1 |
| Faisal, R; Jehangir, T; Shinwari, L | 1 |
| Orchard, D; Yee, J | 1 |
| Cate, JH; Jensen, MK; Marqusee, S; Samelson, AJ; Soto, RA | 1 |
| Apfelbacher, CJ; Bauer, A; Diepgen, TL; Elsner, P; Heinrich, A; Mahler, V; Molin, S; Ofenloch, RF; Schmitt, J; von Kiedrowski, R; Weisshaar, E | 1 |
| Geraghty, AC; Ghanem, RA; Gibson, EM; Goldstein, AK; Greenberg, ME; Greene, JJ; Longo, FM; Marton, RM; Monje, M; Ni, L; Ocampo, A; Paşca, SP; Yang, T | 1 |
| Alakuş, H; Cellat, M; Etyemez, M; Güvenç, M; İşler, CT; Kutlu, T; Kuzu, M | 1 |
| Abdelmeniem, IM; El Eryan, IM; Fouda, I; Nofal, A; Omar, SS | 1 |
| Iqbal, MA; Mumtaz, T; Tahir, A; Tariq, MA | 1 |
4 review(s) available for urea and methotrexate
| Article | Year |
|---|---|
Advances in the treatment of diseases of the skin.
Topics: Acne Vulgaris; Alopecia Areata; Dermatitis, Contact; Humans; Lupus Erythematosus, Systemic; Lymphatic Diseases; Methotrexate; Ointments; Photosensitivity Disorders; Porphyrias; Psoriasis; Rosacea; Skin Diseases; Steroids; Sunscreening Agents; Tetracycline; Tinea; Trichophyton; Urea; Vitiligo | 1971 |
[New principles of treatment in acute leukemia].
Topics: Adolescent; Adult; Antineoplastic Agents; Central Nervous System Diseases; Child; Cyclophosphamide; Cytarabine; Female; Guanidines; Humans; Hydroxyurea; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Leukopenia; Male; Mercaptopurine; Methotrexate; Middle Aged; Nitroso Compounds; Prednisone; Thrombocytopenia; Urea; Uric Acid; Vincristine | 1970 |
Factors pertaining to complete drug-induced remission of tumor in animals and man.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Cytarabine; Humans; Leukemia L1210; Methotrexate; Mice; Neoplasms; Nitroso Compounds; Urea | 1969 |
Monitoring recommendations for oral azathioprine, methotrexate and cyclosporin in a paediatric dermatology clinic and literature review.
Topics: Administration, Oral; Adolescent; Azathioprine; Blood Cell Count; Child; Child, Preschool; Creatinine; Cyclosporine; Drug Monitoring; Electrolytes; Female; Humans; Immunoglobulin E; Immunosuppressive Agents; Liver Function Tests; Male; Methotrexate; Methyltransferases; Retrospective Studies; Skin Diseases; Urea | 2018 |
2 trial(s) available for urea and methotrexate
| Article | Year |
|---|---|
A pharmacist-led information technology intervention for medication errors (PINCER): a multicentre, cluster randomised, controlled trial and cost-effectiveness analysis.
Topics: Adrenergic beta-Antagonists; Amiodarone; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Antimanic Agents; Asthma; Community Pharmacy Services; Contraceptives, Oral, Hormonal; Contraindications; Cost-Benefit Analysis; Drug Information Services; Drug Monitoring; Electrolytes; England; Family Practice; Feedback, Psychological; Humans; Immunosuppressive Agents; Lithium Compounds; Medication Errors; Methotrexate; Peptic Ulcer; Pharmacists; Proton Pump Inhibitors; Regression Analysis; Sodium Potassium Chloride Symporter Inhibitors; Urea | 2012 |
Topical calcipotriol combined with urea 20% versus intralesional injection of triamcinolone acetonide, 5-fluorouracil, and methotrexate in the treatment of nail psoriasis: A comparative study.
Topics: Calcitriol; Dermatologic Agents; Fluorouracil; Humans; Injections, Intralesional; Methotrexate; Nail Diseases; Psoriasis; Treatment Outcome; Triamcinolone Acetonide; Urea | 2022 |
67 other study(ies) available for urea and methotrexate
| Article | Year |
|---|---|
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
A 13C nuclear magnetic resonance study of the interaction of ligands with arginine residues in dihydrofolate reductase.
Topics: Arginine; Ligands; Magnetic Resonance Spectroscopy; Methotrexate; NADP; Protein Binding; Streptococcus; Tetrahydrofolate Dehydrogenase; Urea | 1977 |
Denaturation of thymidylate synthetase from amethopterin-resistant Lactobacillus casei.
Topics: Chromatography, Gel; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Guanidines; Lacticaseibacillus casei; Macromolecular Substances; Methotrexate; Methyltransferases; Protein Denaturation; Spectrometry, Fluorescence; Thymidylate Synthase; Ultracentrifugation; Urea | 1979 |
Present and future uses of hemoperfusion with sorbents.
Topics: Administration, Oral; Adsorption; Animals; Blood Cell Count; Blood Platelets; Charcoal; Coma; Creatinine; Forecasting; Hemoperfusion; Hepatic Encephalopathy; Humans; Hypnotics and Sedatives; Methotrexate; Poisoning; Resins, Synthetic; Urea; Uremia | 1978 |
Efficacy of various locally applied chemicals as contragestational agents in rats.
Topics: Administration, Topical; Animals; Anti-Infective Agents, Local; Cyclizine; Drug Evaluation, Preclinical; Embryo Implantation; Ergonovine; Ethacridine; Ethanol; Female; Fertility; Fetal Resorption; Formaldehyde; Indomethacin; Methotrexate; Nandrolone; Pregnancy; Prostaglandins F; Rats; Silver Nitrate; Urea; Uterus | 1976 |
Permeability of peritoneal membrane "in vitro" under the effect of methotrexate.
Topics: Albumins; Animals; Biological Transport; In Vitro Techniques; Inulin; Methotrexate; Peritoneal Cavity; Rabbits; Urea; Uric Acid | 1989 |
The effect of abolition of the endogenous corticosteroid rhythm on the circadian variation in methotrexate toxicity in the rat.
Topics: Adrenal Cortex Hormones; Animals; Aspartate Aminotransferases; Circadian Rhythm; Corticosterone; Dexamethasone; Drug Interactions; Male; Methotrexate; Rats; Urea | 1987 |
Comparative activity of rat liver dihydrofolate reductase with 7,8-dihydrofolate and other 7,8-dihydropteridines.
Topics: Animals; Enzyme Activation; Folic Acid; Folic Acid Antagonists; Hydrogen-Ion Concentration; Hydroxymercuribenzoates; Kinetics; Liver; Methotrexate; Osmolar Concentration; Pteridines; Rats; Substrate Specificity; Tetrahydrofolate Dehydrogenase; Urea | 1985 |
Implication of a tryptophyl residue in the active site of dihydrofolate reductase.
Topics: Amino Acids; Binding Sites; Chromatography, Gel; Chromatography, Ion Exchange; Dialysis; Drug Resistance, Microbial; Electrophoresis, Polyacrylamide Gel; Folic Acid Antagonists; Lacticaseibacillus casei; Methotrexate; NADP; Oxidation-Reduction; Protein Denaturation; Spectrophotometry, Ultraviolet; Succinimides; Tetrahydrofolate Dehydrogenase; Tryptophan; Urea | 1974 |
Conformational changes induced in dihydrofolate reductase by folates, pyridine nucleotide coenzymes, and methotrexate.
Topics: Folic Acid; Lacticaseibacillus casei; Ligands; Magnetic Resonance Spectroscopy; Methotrexate; NADP; Protein Conformation; Protein Denaturation; Tetrahydrofolate Dehydrogenase; Urea | 1974 |
Polygammaglutamyl metabolites of methotrexate.
Topics: Acute Disease; Animals; Chloroform; Chromatography, DEAE-Cellulose; Chromatography, Paper; Enterococcus faecalis; Glutamates; Leukemia; Male; Methotrexate; Molecular Weight; Organ Specificity; Polymers; Protein Conformation; Protein Denaturation; Rats; Tritium; Urea | 1973 |
Studies on the chemotherapy of experimental brain tumors: evaluation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea, vincristine, and 5-fluorouracil.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cyclophosphamide; Disease Models, Animal; Ependymoma; Evaluation Studies as Topic; Fluorouracil; Glioma; Injections, Intraperitoneal; Male; Methotrexate; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Nitroso Compounds; Nitrosourea Compounds; Plicamycin; Urea; Vincristine | 1971 |
Current trends in the chemotherapy of brain tumors with special reference to glioblastomas.
Topics: Alkaloids; Antibiotics, Antineoplastic; Antineoplastic Agents; Azaguanine; Blood Vessel Prosthesis; Blood-Brain Barrier; Brain; Brain Neoplasms; Bromodeoxyuridine; Cell Division; Cell Transformation, Neoplastic; Disease Models, Animal; Fluorouracil; Glioblastoma; Humans; Injections, Intra-Arterial; Injections, Spinal; Mechlorethamine; Methotrexate; Nitroso Compounds; Thiotepa; Time Factors; Urea; Vincristine | 1969 |
The essential SH-groups in folate reductase.
Topics: Animals; Benzoates; Binding Sites; Chemical Phenomena; Chemistry; Culture Techniques; Folic Acid; Folic Acid Antagonists; Methotrexate; NADP; Sarcoma 180; Sulfhydryl Compounds; Temperature; Tetrahydrofolate Dehydrogenase; Urea | 1968 |
Bacteriophage tail components. II. Dihydrofolate reductase in T4D bacteriophage.
Topics: Aminopterin; Animals; Binding Sites; Coliphages; Escherichia coli; Fluorometry; Folic Acid Antagonists; Formamides; Genes; Genetic Complementation Test; Genetics, Microbial; Immune Sera; Methotrexate; Mutation; NAD; NADP; Rabbits; Solvents; Spectrophotometry; Tetrahydrofolate Dehydrogenase; Urea; Viral Proteins; Virus Replication | 1970 |
A soluble dihydrofolate reductase from human placenta: purification and properties.
Topics: Chemical Precipitation; Chromatography, Gel; Chromatography, Ion Exchange; Enzyme Activation; Female; Folic Acid Antagonists; Humans; Hydrogen-Ion Concentration; Hydroxyapatites; Kinetics; Methotrexate; Molecular Weight; NADP; Placenta; Potassium Chloride; Solubility; Tetrahydrofolate Dehydrogenase; Urea | 1971 |
Dihydrofolate reductase from amethopterin-resistant Lactobacillus casei.
Topics: Acetates; Amino Acids; Ammonium Sulfate; Chromatography; Chromatography, Gel; Chromatography, Ion Exchange; Drug Resistance, Microbial; Electrophoresis; Folic Acid; Folic Acid Antagonists; Hydroxyapatites; Lacticaseibacillus casei; Lactobacillus; Methotrexate; Molecular Weight; NADP; Protein Binding; Sodium Dodecyl Sulfate; Spectrophotometry; Tetrahydrofolate Dehydrogenase; Ultracentrifugation; Ultraviolet Rays; Urea | 1972 |
Dihydrofolate reductase from mouse liver and spleen. Purification, properties and inhibition by substituted 2,4-diaminopyrimidines and 4,6-diaminotriazines.
Topics: Animals; Antigen-Antibody Reactions; Cell Line; Chromatography; Chromatography, Gel; Enzyme Activation; Folic Acid; Folic Acid Antagonists; Guanidines; Hot Temperature; Hydrogen-Ion Concentration; Kinetics; Leukemia L1210; Liver; Lymphoma; Methotrexate; Mice; Mice, Inbred Strains; NADP; Potassium Chloride; Protein Denaturation; Pyrimidines; Spleen; Tetrahydrofolate Dehydrogenase; Triazines; Urea | 1971 |
Methotrexate treatment for advanced bladder cancer.
Topics: Aged; Blood Cell Count; Carcinoma, Transitional Cell; Creatinine; Diarrhea; Humans; Kidney Function Tests; Kidney Neoplasms; Leukopenia; Lymphatic Metastasis; Male; Methotrexate; Middle Aged; Nausea; Neoplasm Metastasis; Urea; Urinary Bladder; Urinary Bladder Neoplasms; Urography; Vomiting | 1974 |
Evaluation of antileukemic agents in advanced leukemia L1210 in mice. X.
Topics: Alkylating Agents; Amides; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Cytarabine; Imidazoles; Leukemia L1210; Male; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Nitrosourea Compounds; Purines; Pyrimidines; Time Factors; Urea | 1972 |
Purification and properties of dihydrofolate reductase from cultured mammalian cells.
Topics: Cell Line; Cells, Cultured; Chromatography, Affinity; Electrophoresis, Polyacrylamide Gel; Folic Acid Antagonists; Humans; Hydrogen-Ion Concentration; Hydroxymercuribenzoates; Kinetics; Methotrexate; Molecular Weight; Polysaccharides; Potassium Chloride; Spectrophotometry, Ultraviolet; Tetrahydrofolate Dehydrogenase; Trimethoprim; Urea | 1973 |
The effect of cancer chemotherapeutic agents on fibrin formation and stabilization in vitro.
Topics: Antineoplastic Agents; Asparaginase; Blood Coagulation Tests; Cyclophosphamide; Cytarabine; Dactinomycin; Daunorubicin; Doxorubicin; Electric Conductivity; Factor XIII; Fibrin; Fibrinolysis; Fluorouracil; Humans; Hydrogen-Ion Concentration; Imidazoles; In Vitro Techniques; Mechlorethamine; Methotrexate; Microscopy, Electron; Nitrogen Mustard Compounds; Solubility; Triazenes; Urea; Vinblastine; Vincristine | 1974 |
Systemic chemotherapy for carcinoma of the cervix.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; Cyclophosphamide; Female; Fluorouracil; Humans; Hydroxyurea; Mechlorethamine; Melphalan; Methotrexate; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Progestins; Thiotepa; Urea; Uterine Cervical Neoplasms | 1967 |
Killing of cells in bacterial colonies.
Topics: Anti-Bacterial Agents; Antineoplastic Agents; Azaserine; Chloramphenicol; Enterococcus faecalis; Escherichia coli; Fluorouracil; Kinetics; Methotrexate; Nitroso Compounds; Penicillin G; Urea | 1967 |
Remission maintenance therapy for meningeal leukemia: intrathecal methotrexate vs. intravenous bis-nitrosourea.
Topics: Adolescent; Bone Marrow Examination; Child; Child, Preschool; Fever; Headache; Humans; Injections, Intravenous; Injections, Spinal; Leukemia; Meninges; Methotrexate; Neuritis; Nitroso Compounds; Remission, Spontaneous; Urea; Vomiting | 1971 |
Treatment of the acute leukemias.
Topics: Antineoplastic Agents; Cyclophosphamide; Cytarabine; Daunorubicin; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Nitroso Compounds; Prednisone; Urea; Vincristine | 1967 |
Methotrexate infusions and intensive supportive care in the management of children with acute lymphocytic leukemia: follow-up report.
Topics: Cyclophosphamide; Follow-Up Studies; Infusions, Parenteral; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Nitroso Compounds; Prednisone; Tablets; Urea; Vincristine | 1967 |
Summary: recent advances in the treatment of acute leukemia and Burkitt's tumor.
Topics: Antineoplastic Agents; Asparaginase; Burkitt Lymphoma; Cyclophosphamide; Cytarabine; Daunorubicin; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Nitroso Compounds; Prednisone; Urea; Vincristine | 1967 |
Skin homograft survival in cancer chemotherapy patients.
Topics: Adult; Aged; Antineoplastic Agents; Carbamates; Female; Fluorouracil; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Mitomycins; Neoplasms; Skin Transplantation; Transplantation, Homologous; Urea | 1966 |
Combinations, schedules, and new agents for the chemotherapy of acute leukemia.
Topics: Acute Disease; Adult; Antineoplastic Agents; Child; Cyclophosphamide; Cytarabine; Daunorubicin; Humans; Leukemia; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Nitroso Compounds; Prednisone; Urea; Vincristine | 1970 |
Studies on the chemotherapy of experimental brain tumors: evaluation of 1,3-bis(2-chloroethyl)-l-nitrosourea, cyclophosphamide, mithramycin, and methotrexate.
Topics: Animals; Antibiotics, Antineoplastic; Blood-Brain Barrier; Brain Neoplasms; Cyclophosphamide; Disease Models, Animal; Ependymoma; Glioma; Injections; Male; Methotrexate; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Nitroso Compounds; Statistics as Topic; Urea | 1970 |
Effects of chemotherapeutic agents on normal mouse bone marrow grown in vitro.
Topics: Animals; Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Culture Media; Culture Techniques; Cyclophosphamide; Cytosine Nucleotides; Hematopoiesis; Male; Methotrexate; Methylcellulose; Mice; Nitrogen Mustard Compounds; Nitroso Compounds; Nucleosides; Polynucleotides; Urea; Vinblastine | 1971 |
Medulloblastoma.
Topics: Adolescent; Age Factors; Brain Neoplasms; Child; Child, Preschool; Female; Gold Isotopes; Humans; Infant; Male; Medulloblastoma; Methotrexate; Myelography; Neoplasm Metastasis; Nitroso Compounds; Radionuclide Imaging; Radiotherapy Dosage; Spinal Cord Neoplasms; Urea | 1971 |
Dihydrofolate reductase of Streptococcus faicium. II. Purification and some properties of two dihydrofolate reductases from the amethopterin-resistant mutant Streptococcus faecium var. Durans strain A.
Topics: Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Drug Resistance, Microbial; Electrophoresis; Hydrogen-Ion Concentration; Kinetics; Mercury; Methotrexate; Spectrum Analysis; Streptococcus; Tetrahydrofolate Dehydrogenase; Ultracentrifugation; Urea | 1968 |
1,3-bis(2-chloroethyl)-1-nitrosourea (NSC-409962) and methotrexate (NSC-740) as combination therapy for advanced mouse leukemia L1210.
Topics: Animals; Female; Leukemia L1210; Male; Methotrexate; Mice; Nitroso Compounds; Urea | 1965 |
Elevation of deoxyribonuclease activities in HeLa cells treated with selective inhibitors of DNA synthesis.
Topics: Antimetabolites; Cell Division; Culture Techniques; Deoxyribonucleases; DNA; HeLa Cells; Humans; Mechlorethamine; Methotrexate; Mitomycins; Thymidine; Urea | 1966 |
Action of methotrexate on metabolism of lipids and carbohydrates of the perfused isolated liver.
Topics: Animals; Blood Glucose; Carbohydrate Metabolism; Cholesterol; Fatty Acids, Nonesterified; In Vitro Techniques; Ketone Bodies; Lipid Metabolism; Liver; Liver Glycogen; Male; Methotrexate; Phospholipids; Rats; Triglycerides; Urea | 1967 |
Long-term survival of patients with Burkitt's lymphoma: an assessment of treatment and other factors which may relate to survival.
Topics: Adolescent; Antineoplastic Agents; Burkitt Lymphoma; Busulfan; Child; Child, Preschool; Chlorambucil; Cyclophosphamide; Cytarabine; Female; Humans; Immunotherapy; Infant; Kenya; Male; Mannitol; Melphalan; Methotrexate; Nitrogen Mustard Compounds; Nitroso Compounds; Urea | 1967 |
Criteria associated with destruction of leukemia and solid tumor cells in animals.
Topics: Animals; Cricetinae; Cyclophosphamide; Cytarabine; Leukemia L1210; Methotrexate; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Nitroso Compounds; Urea | 1967 |
Informal discussion: experimental basis for the chemical eradication of leukemia.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Cytarabine; Drug Antagonism; Drug Synergism; Humans; Leukemia; Liver; Methotrexate; Mice; Nitroso Compounds; Urea | 1967 |
The effect of timing of a single injection on the toxicity of methotrexate in the rat.
Topics: Animals; Aspartate Aminotransferases; Blood Cell Count; Circadian Rhythm; Half-Life; Kinetics; Male; Methotrexate; Rats; Time Factors; Urea | 1982 |
19F NMR spectroscopy of [6-19F]tryptophan-labeled Escherichia coli dihydrofolate reductase: equilibrium folding and ligand binding studies.
Topics: Base Sequence; Binding Sites; DNA Primers; Escherichia coli; Ligands; Magnetic Resonance Spectroscopy; Methotrexate; Molecular Sequence Data; Mutagenesis, Site-Directed; NADP; Protein Conformation; Protein Folding; Tetrahydrofolate Dehydrogenase; Tryptophan; Urea | 1994 |
Collapse of parallel folding channels in dihydrofolate reductase from Escherichia coli by site-directed mutagenesis.
Topics: Circular Dichroism; Cysteine; Escherichia coli; Flow Cytometry; Folic Acid Antagonists; Kinetics; Magnetic Resonance Spectroscopy; Methotrexate; Mutagenesis, Site-Directed; NADP; Protein Conformation; Protein Folding; Tetrahydrofolate Dehydrogenase; Thermodynamics; Urea | 1993 |
A reexamination of the folding mechanism of dihydrofolate reductase from Escherichia coli: verification and refinement of a four-channel model.
Topics: Binding Sites; Escherichia coli; Folic Acid Antagonists; Kinetics; Methotrexate; Protein Folding; Spectrometry, Fluorescence; Spectrophotometry; Tetrahydrofolate Dehydrogenase; Urea | 1993 |
Permeability and metabolic properties of a trophoblast cell line (HRP-1) derived from normal rat placenta.
Topics: Animals; Biological Transport; Biomarkers; Carbon Radioisotopes; Cell Culture Techniques; Cell Line; Cell Membrane Permeability; Cytochrome P-450 CYP1A1; Dermatologic Agents; Dextrans; Female; Fluorescein; Fluoresceins; Humans; Linoleic Acid; Linoleic Acids; Mannitol; Methotrexate; Microsomes; Oxazines; Rats; Sucrose; Transferrin; Trophoblasts; Urea | 1997 |
cis and trans sites of the TOM complex of mitochondria in unfolding and initial translocation of preproteins.
Topics: Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cytochromes c1; Intracellular Membranes; Kinetics; Macromolecular Substances; Membrane Proteins; Methotrexate; Mice; Mitochondria; Neurospora crassa; Osmolar Concentration; Protein Folding; Protein Precursors; Proton-Translocating ATPases; Recombinant Fusion Proteins; Tetrahydrofolate Dehydrogenase; Urea | 1998 |
Dynamics of the TOM complex of mitochondria during binding and translocation of preproteins.
Topics: Antibodies; Chromatography, Gel; Cross-Linking Reagents; Fungal Proteins; Intracellular Membranes; Macromolecular Substances; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mitochondria; Mitochondrial Membrane Transport Proteins; Molecular Weight; Neurospora crassa; Protein Precursors; Protein Processing, Post-Translational; Receptors, Cell Surface; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Urea | 1998 |
Testing the role of chain connectivity on the stability and structure of dihydrofolate reductase from E. coli: fragment complementation and circular permutation reveal stable, alternatively folded forms.
Topics: Circular Dichroism; Crystallography, X-Ray; Enzyme Inhibitors; Enzyme Stability; Escherichia coli; Methotrexate; Peptide Fragments; Protein Conformation; Protein Denaturation; Protein Folding; Spectrometry, Fluorescence; Tetrahydrofolate Dehydrogenase; Urea | 2001 |
Highly divergent dihydrofolate reductases conserve complex folding mechanisms.
Topics: Amino Acid Sequence; Anilino Naphthalenesulfonates; Apoproteins; Binding Sites; Conserved Sequence; Cyclophilins; Enzyme Stability; Escherichia coli; Evolution, Molecular; Fluorescence; Humans; Kinetics; Lacticaseibacillus casei; Ligands; Methotrexate; Models, Molecular; Molecular Sequence Data; NADP; Protein Conformation; Protein Denaturation; Protein Folding; Protein Renaturation; Tetrahydrofolate Dehydrogenase; Thermodynamics; Urea | 2002 |
Weekly pulse therapy of methotrexate improves survival compared with its daily administration in MRL/lpr mice.
Topics: Animals; Antirheumatic Agents; Autoantibodies; Autoimmunity; Blood Cell Count; Body Weight; Glomerulonephritis; Kidney Function Tests; Lupus Erythematosus, Systemic; Lymphatic Diseases; Male; Methotrexate; Mice; Mice, Inbred MRL lpr; Proteinuria; Radiography; Survival Analysis; Urea | 2002 |
The coordination of the isomerization of a conserved non-prolyl cis peptide bond with the rate-limiting steps in the folding of dihydrofolate reductase.
Topics: Circular Dichroism; Escherichia coli; Fluorescence; Fluorescence Resonance Energy Transfer; Folic Acid Antagonists; Kinetics; Ligands; Magnetic Resonance Spectroscopy; Methotrexate; Models, Chemical; Mutagenesis, Site-Directed; NADP; Protein Binding; Protein Conformation; Protein Folding; Tetrahydrofolate Dehydrogenase; Thermodynamics; Urea | 2003 |
IMMUNOSUPPRESSIVE DRUG THERAPY IN CANINE RENAL AND SKIN HOMOGRAFTS.
Topics: Allergy and Immunology; Allografts; Animals; Azaserine; Dactinomycin; Dogs; Immunosuppressive Agents; Kidney Transplantation; Leukopenia; Methotrexate; Purines; Pyrazoles; Pyrimidines; Research; Skin Transplantation; Thrombocytopenia; Urea | 1963 |
FURTHER OBSERVATIONS OF THE BINDING AND INHIBITION OF DIHYDROFOLIC REDUCTASE BY FOLIC ACID ANTAGONISTS.
Topics: Aminopterin; Animals; Chromatography; Dialysis; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Hot Temperature; Leukemia L1210; Liver; Methotrexate; Mice; Oxidoreductases; Pharmacology; Potassium; Poultry; Renal Dialysis; Research; Tritium; Urea | 1964 |
IN VIVO ANTIVIRAL ACTIVITY OF 1,3-BIS(2-CHLOROETHYL)-1-NITROSOUREA.
Topics: Alkylating Agents; Animals; Antiviral Agents; Avian Sarcoma Viruses; Carmustine; Encephalitis Viruses; Enterovirus C, Human; Forests; Herpesviridae; Leukemia Virus, Murine; Lymphocytic Choriomeningitis; Lymphocytic choriomeningitis virus; Methotrexate; Mice; Nitroso Compounds; Nitrosourea Compounds; Orthomyxoviridae; Pharmacology; Poliovirus; Poultry; Research; Rous sarcoma virus; Semliki forest virus; Simplexvirus; Splenomegaly; Urea; Vaccinia virus; Viruses | 1965 |
Methotrexate: improving safety profile.
Topics: Blood Chemical Analysis; Collagen Type III; Dermatologic Agents; Drug Monitoring; Drug Utilization Review; Electrolytes; Folic Acid; Humans; Liver Function Tests; Methotrexate; Patient Education as Topic; Practice Patterns, Physicians'; Psoriasis; United Kingdom; Urea | 2006 |
Transdermal delivery of the anti-rheumatic agent methotrexate using a solid-in-oil nanocarrier.
Topics: Administration, Cutaneous; Amino Acids; Animals; Antirheumatic Agents; Drug Carriers; Drug Delivery Systems; Drug Stability; Female; Methotrexate; Myristates; Nanostructures; Particle Size; Permeability; Skin Absorption; Solvents; Surface-Active Agents; Swine; Swine, Miniature; Urea | 2012 |
The protective effects of Prunus armeniaca L (apricot) against methotrexate-induced oxidative damage and apoptosis in rat kidney.
Topics: Acute Kidney Injury; Animals; Antioxidants; Apoptosis; Catalase; Creatinine; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Kidney; Lipid Peroxidation; Male; Methotrexate; Oxidative Stress; Protective Agents; Prunus; Rats; Rats, Wistar; Superoxide Dismutase; Urea | 2013 |
PSMA-targeted stably linked "dendrimer-glutamate urea-methotrexate" as a prostate cancer therapeutic.
Topics: Antigens, Surface; Click Chemistry; Dendrimers; Drug Delivery Systems; Glutamate Carboxypeptidase II; Glutamic Acid; Humans; Male; Methotrexate; Nanoparticles; Prostatic Neoplasms; Urea | 2014 |
A simple N,N'-dicyclohexylurea adduct of β-alanine can self-assemble to generate nano-morphological versatility in response to different environmental conditions.
Topics: Alanine; Drug Carriers; Methotrexate; Nanostructures; Urea | 2014 |
Prevention of methotrexate-induced nephrotoxicity by concomitant administration of garlic aqueous extract in rat.
Topics: Adenosine Deaminase; Animals; Calcium; Catalase; Creatinine; Disease Models, Animal; Garlic; Glutathione; Kidney Diseases; Male; Malondialdehyde; Methotrexate; Nitric Oxide; Phosphorus; Plant Extracts; Potassium; Rats; Rats, Wistar; Sodium; Urea | 2015 |
Comparison of the Therapeutic Effects of Thymoquinone and Methotrexate on Renal Injury in Pristane Induced Arthritis in Rats.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Benzoquinones; Creatinine; Female; Humans; Inflammation; Kidney; Leukocyte Count; Methotrexate; Random Allocation; Rats; Rats, Sprague-Dawley; Terpenes; Urea | 2015 |
Quantitative determination of ribosome nascent chain stability.
Topics: Escherichia coli; Methotrexate; Peptide Hydrolases; Protein Biosynthesis; Protein Folding; Protein Stability; Proteolysis; Recombinant Proteins; Ribosomes; Spectrometry, Fluorescence; Urea | 2016 |
Chronic hand eczema in Germany: 5-year follow-up data from the CARPE registry.
Topics: Acitretin; Administration, Cutaneous; Adolescent; Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Alitretinoin; Chronic Disease; Dermatitis, Allergic Contact; Dermatologic Agents; Eczema; Female; Follow-Up Studies; Hand Dermatoses; Humans; Male; Methotrexate; Middle Aged; Outcome Assessment, Health Care; Patient Reported Outcome Measures; PUVA Therapy; Registries; Ultraviolet Therapy; Urea; Young Adult | 2019 |
Loss of Adaptive Myelination Contributes to Methotrexate Chemotherapy-Related Cognitive Impairment.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Channelrhodopsins; Cognition Disorders; Disease Models, Animal; Humans; Immunosuppressive Agents; Luminescent Proteins; Membrane Glycoproteins; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myelin Sheath; Oligodendrocyte Precursor Cells; Organic Chemicals; Protein-Tyrosine Kinases; Recognition, Psychology; Signal Transduction; Urea | 2019 |
Investigation of the effects of safranal on the experimentally created rheumatoid arthritis model in rats.
Topics: Alanine; Animals; Antioxidants; Arthritis, Experimental; Arthritis, Rheumatoid; Aspartate Aminotransferases; C-Reactive Protein; Catalase; Creatinine; Cyclohexenes; Cyclooxygenase 2; Freund's Adjuvant; Glutathione; Glutathione Peroxidase; Interleukin-6; Malondialdehyde; Methotrexate; NF-kappa B; Rats; Terpenes; Tumor Necrosis Factor-alpha; Urea | 2022 |
Comparative analysis of multiorgan toxicity induced by long term use of disease modifying anti-rheumatic drugs.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Creatinine; Humans; Leflunomide; Methotrexate; Renal Insufficiency; Urea; Uric Acid | 2023 |