urea and hydroxyurea

urea has been researched along with hydroxyurea in 86 studies

Research

Studies (86)

Timeframe	Studies, this research(%)	All Research%
pre-1990	69 (80.23)	18.7374
1990's	10 (11.63)	18.2507
2000's	4 (4.65)	29.6817
2010's	3 (3.49)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Hayflick, L; Masover, GK; Sawyer, JE	1
Fishbein, WN	2
Brown, PR; Gregoriou, M	1
Baird, MA; Sampson, EJ	1
Timson, J	1
Greig, MA; Hossack, M; McColl, KE; Neithercut, WD	1
Bailey, LC; Main, KB; Medwick, T; Shinkai, JH	1
Lee, MS; Lin, DP; Wang, CY	1
Stetter, H; Weber, G	1
Amiel, JJ; Cattan, A; Gluckman, E; Mathé, G; Schlumberger, JR; Schneider, M; Schwarzenberg, L	1
Cameron, IL; Jeter, JR	1
Box, VL; Brown, VK	1
Carr, HS; Pollak, RD; Rosenkranz, S	1
Brunner, KW	1
Dano, K; Nissen, NI	1
Burns, BC; Rutledge, F; Smith, JP; Soffar, S	1
Beckloff, GL; Brady, LW; Faust, DS; LePar, E	1
Sugiura, K	1
Sinclair, WK	2
Shepard, MC	1
Gale, GR	2
Bono, VH; Colvin, M	1
Daly, JE; Fishbein, WN	1
Abrams, R; Lieberman, I; Turner, MK	1
Bell, C; Borman, A; Freeman, JJ; Hilf, R; Michel, I	1
Bianchi, A; Borman, A; Lerner, LJ; Yiacas, E	1
Bianchi, A; Dzelzkalns, M; Lerner, LJ	1
Gothoskar, BP; Ranadive, KJ; Rbose, S	1
Beckloff, GL; Lerner, HJ	2
Pfeiffer, SE; Tolmach, LJ	1
Cronin, AP; Philips, FS; Schwartz, HS; Sodergren, JE; Sternberg, SS; Vidal, PM	1
Karnofsky, DA; Schochetman, G; Young, CW	1
Balis, ME; Hodas, S; Schochetman, G; Young, CW	1
Adams, RL; Lindsay, JG	1
Beckloff, GL; Lerner, HJ; Lipshutz, H	1
Poillon, WN	1
Fuller, BJ; Green, CJ; Lane, NJ; Manek, S; Thorniley, MS	1
Bryant, ML; Clare, M; DeCrescenzo, GA; Getman, DP; Heintz, RM; Houseman, KA; Marr, JJ; Mueller, RA; Reed, KL; Talley, JJ	1
Braeckman, RA; Erdman, KA; Granneman, GR	1
Awni, WM; Braeckman, RA; Dubé, LM; Granneman, GR; Witt, G	1
Awni, WM; Cavanaugh, JH; Dubé, LM; el-Shourbagy, T; Locke, CS; Wong, SL	1
Ferrero, JL; Machinist, JM; Mayer, MD; Rodrigues, AD; Shet, MS	1
Awni, WM; Cavanaugh, JH; Dube, LM; Locke, C	1
Kearney, AS; McLoughlin, M; Palepu, NR	1
Burkovski, A; Eggeling, L; Jahns, T; Krämer, R; Siewe, RM; Weil, B	1
Chung, SJ; Kim, DH	1
Adunyah, SE; Asakura, T; Baliga, S; Fasold, H; Horiuchi, K; Iyamu, EW; Ohene-Frempong, K; Turner, EA	1
BLOEDOW, C; DAVIS, P; GRIFFITH, KM; HOWE, CD; LANE, M; LEVIN, WC; SULLIVAN, MP; THURMAN, WG	1
DAVIDSON, JD; WINTER, TS	1
CARBONE, PP; FISHBEIN, WN	2
MOHLER, WC	1
BEATTY, EC; BRUBAKER, C; HAMMOND, D; HARTMANN, JR; ORIGENES, ML; SHORE, N; WILLIAMS, KO	1
BERNSTEIN, J; LOSEE, KA; STEARNS, B	1
DUBOIS, S; GALE, GR; KENDALL, SM; MCLAIN, HH	1
BOLTON, BH; KAUNG, DT; LAWTON, RL; WOODS, LA	2
HODAS, S; YOUNG, CW	1
ALFREY, CP; DE BERGSAGEL, DE; FRENKEL, EP; THURMAN, WG	1
FRENKEL, EP; SKINNER, WN; SMILEY, JD	1
CHAUBE, S; MURPHY, ML	1
THURMAN, WG; WATKINS, WL	1
ALFREY, CP; DALE, SC; FRENKEL, EP; KARJALA, RJ; LANE, M	1
SEARS, ME	2
GRIFFITH, KM	1
FERNBACH, DJ	1
BLOEDOW, CE	1
BICKERS, JN	1
SHULLENBERGER, CC	1
DAVIS, P	1
KRAKOFF, IH; MURPHY, ML; SAVEL, H	1
GLYNN, JP; GOLDIN, A; MEAD, JA; VENDITTI, JM	1
HOWE, CD; SAMUELS, ML	1
DAVIDSON, JD; FISHBEIN, WN; WINTER, TS	1
ADAMSON, RH	1
Beitz, E; Pavlovic-Djuranovic, S; Schultz, JE	1
Alegre, E; Monreal, JI; Mugueta, C; Restituto, P; Varo, N	1
Astier, A; Bachir, D; Galactéros, F; Habibi, A; Hulin, A; Sassi, H	1
Maserati, R; Uglietti, A	1

Reviews

4 review(s) available for urea and hydroxyurea

Article	Year
Hydroxyurea. Mutation research, 1975, Volume: 32, Issue:2 Topics: Animals; Chromosome Aberrations; DNA; DNA Repair; DNA Replication; Humans; Hydroxyurea; Mice; Mitosis; Mutagens; Rats; RNA; Structure-Activity Relationship; Teratogens; Urea	1975
[Progress in the drug therapy of cancer]. Medizinische Klinik, 1968, Apr-26, Volume: 63, Issue:17 Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Asparaginase; Cytarabine; Daunorubicin; Drug Synergism; Humans; Hydrazines; Hydroxyurea; Neoplasms; Nitroso Compounds; Picolinic Acids; Pyrogallol; Quinolines; Streptonigrin; Urea	1968
[New principles of treatment in acute leukemia]. Ugeskrift for laeger, 1970, Apr-30, Volume: 132, Issue:18 Topics: Adolescent; Adult; Antineoplastic Agents; Central Nervous System Diseases; Child; Cyclophosphamide; Cytarabine; Female; Guanidines; Humans; Hydroxyurea; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Leukopenia; Male; Mercaptopurine; Methotrexate; Middle Aged; Nitroso Compounds; Prednisone; Thrombocytopenia; Urea; Uric Acid; Vincristine	1970
Antiviral hyperactivation-limiting therapeutics as a novel class for the treatment of HIV/AIDS: focus on VS411. Expert opinion on investigational drugs, 2011, Volume: 20, Issue:4 Topics: Acquired Immunodeficiency Syndrome; Anti-HIV Agents; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Clinical Trials as Topic; Didanosine; Drug Combinations; Drug Evaluation, Preclinical; HIV Infections; Humans; Hydroxyurea; Lymphocyte Activation; Urea; Viral Load	2011

Trials

3 trial(s) available for urea and hydroxyurea

Article	Year
Pharmacokinetics and pharmacodynamics of zileuton after oral administration of single and multiple dose regimens of zileuton 600mg in healthy volunteers. Clinical pharmacokinetics, 1995, Volume: 29 Suppl 2 Topics: Adolescent; Adult; Chromatography, High Pressure Liquid; Circadian Rhythm; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Fasting; Humans; Hydroxylation; Hydroxyurea; Leukotriene B4; Lipoxygenase Inhibitors; Male; Middle Aged; Stereoisomerism; Urea; White People	1995
The pharmacokinetics of single oral doses of zileuton 200 to 800mg, its enantiomers, and its metabolites, in normal healthy volunteers. Clinical pharmacokinetics, 1995, Volume: 29 Suppl 2 Topics: Absorption; Administration, Oral; Adult; Analysis of Variance; Biological Availability; Blood Proteins; Chromatography, High Pressure Liquid; Cross-Over Studies; Dose-Response Relationship, Drug; Glomerular Filtration Rate; Glucuronates; Half-Life; Humans; Hydroxylation; Hydroxyurea; Kidney Tubules, Proximal; Lipoxygenase Inhibitors; Male; Middle Aged; Protein Binding; Stereoisomerism; Urea	1995
Evaluation of the diurnal variation in the pharmacokinetics of zileuton in healthy volunteers. Journal of clinical pharmacology, 1997, Volume: 37, Issue:5 Topics: Adolescent; Adult; Circadian Rhythm; Cross-Over Studies; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Male; Urea	1997

Other Studies

79 other study(ies) available for urea and hydroxyurea

Article	Year
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Urea-hydrolyzing activity of a T-strain mycoplasma: Ureaplasma urealyticum. Journal of bacteriology, 1976, Volume: 125, Issue:2 Topics: Bacteriolysis; Carbon Dioxide; Cell-Free System; Digitonin; Edetic Acid; Gold; Hydrogen-Ion Concentration; Hydrolysis; Hydroxamic Acids; Hydroxyurea; Mycoplasmataceae; Temperature; Thallium; Thiourea; Urea; Urease	1976
Formamide: the minimum-structure substrate for urease. Biochimica et biophysica acta, 1977, Oct-13, Volume: 484, Issue:2 Topics: Binding, Competitive; Formamides; Hydrogen-Ion Concentration; Hydroxyurea; Kinetics; Plants; Semicarbazides; Structure-Activity Relationship; Substrate Specificity; Urea; Urease	1977
Inhibition of the aliphatic amidase from Pseudomonas aeruginosa by urea and related compounds. European journal of biochemistry, 1979, May-02, Volume: 96, Issue:1 Topics: Amidohydrolases; Cyanates; Enzyme Activation; Hydroxyurea; Kinetics; Molecular Weight; Pseudomonas aeruginosa; Urea	1979
Chemical inhibition used in a kinetic urease/glutamate dehydrogenase method for urea in serum. Clinical chemistry, 1979, Volume: 25, Issue:10 Topics: Autoanalysis; Bilirubin; Colorimetry; Fluorides; Glutamate Dehydrogenase; Humans; Hydroxyurea; Kinetics; Methods; Urea; Urease	1979
Harnessing of urease activity of Helicobacter pylori to induce self-destruction of the bacterium. Journal of clinical pathology, 1991, Volume: 44, Issue:2 Topics: Buffers; Citrates; Citric Acid; Culture Media; Helicobacter pylori; Hydrogen-Ion Concentration; Hydroxyurea; Urea; Urease	1991
Quantitative analysis of hydroxyurea and urea by proton nuclear magnetic resonance (NMR) spectroscopy. Pharmaceutical research, 1987, Volume: 4, Issue:5 Topics: Hydroxyurea; Magnetic Resonance Spectroscopy; Urea	1987
Mutagenicity of the anticancer drug, caracemide, and related compounds for salmonella. Mutation research, 1986, Volume: 172, Issue:3 Topics: Animals; Antineoplastic Agents; Female; Hydrolysis; Hydroxamic Acids; Hydroxylamines; Hydroxyurea; Rats; Salmonella typhimurium; Structure-Activity Relationship; Urea	1986
[An unknown metabolic disturbance of psoriasis vulgaris (author's transl)]. Archiv fur dermatologische Forschung, 1974, Volume: 251, Issue:2 Topics: Adolescent; Adult; Dermatitis, Exfoliative; Dietary Proteins; Female; Humans; Hydroxyurea; Lymphocytes; Male; Middle Aged; Nephritis, Interstitial; Protein Biosynthesis; Psoriasis; Urea; Uremia	1974
[Trial treatment of chronic myeloid leukemia with 3 new chemotherapeutic agents: dibromomannitol, hydroxyurea and desacetamidocolchicine]. La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1966, Nov-26, Volume: 42, Issue:49 Topics: Adult; Antineoplastic Agents; Colchicine; Female; Humans; Hydroxyurea; Leukemia, Myeloid; Male; Mannitol; Urea	1966
Action of hydroxyurea and N-carbamoyloxyurea on the cell cycle of Tetrahymena. Cell and tissue kinetics, 1973, Volume: 6, Issue:3 Topics: Animals; Autoradiography; Cell Division; Cell Survival; DNA; Hydroxyurea; Tetrahymena pyriformis; Thymidine; Tritium; Urea	1973
Some effects of systemic N-hydroxyurea and N-hydroxyurethane on normal and n-hexadecane-treated rat skin in vivo. The Journal of investigative dermatology, 1973, Volume: 61, Issue:1 Topics: Animals; Arginase; Female; Hydroxyurea; Injections, Intraperitoneal; Rats; Skin; Sodium Chloride; Solutions; Urea; Urethane	1973
Studies with hydroxyurea. VI. Effects of hydroxyurea on the metabolism of sensitive and resistant strains of Escherichia coli. Biochimica et biophysica acta, 1967, Nov-21, Volume: 149, Issue:1 Topics: Carbamates; Depression, Chemical; DNA, Bacterial; Drug Resistance, Microbial; Escherichia coli; Folic Acid; Genetics, Microbial; Hydroxyurea; Models, Biological; Nucleosides; Oxidation-Reduction; Thioctic Acid; Thymidine; Tritium; Urea; Urethane; Vitamin B 12	1967
Systemic chemotherapy for carcinoma of the cervix. American journal of obstetrics and gynecology, 1967, Mar-15, Volume: 97, Issue:6 Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; Cyclophosphamide; Female; Fluorouracil; Humans; Hydroxyurea; Mechlorethamine; Melphalan; Methotrexate; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Progestins; Thiotepa; Urea; Uterine Cervical Neoplasms	1967
Clinical evaluation of the adjunctive use of hydroxyurea (NSC-32065) in radiation therapy of carcinoma of the lung. A comparative study. Radiologia clinica et biologica, 1967, Volume: 36, Issue:1 Topics: Adult; Aged; Antineoplastic Agents; Carcinoma; Carcinoma, Squamous Cell; Female; Humans; Hydroxyurea; Lung Neoplasms; Male; Middle Aged; Radiotherapy, High-Energy; Urea	1967
Effect of 1,3-bis(2-chloroethyl)-1-nitrosourea (NSC-409962) and two related compounds on a spectrum of tumors. Cancer research, 1967, Volume: 27, Issue:3 Pt 2 Topics: Adenocarcinoma; Animals; Carcinoma, Ehrlich Tumor; Carcinoma, Krebs 2; Fibrosarcoma; Glioma; Hydroxyurea; Leukemia, Experimental; Lymphoma, Non-Hodgkin; Melanoma; Mice; Neoplasms, Experimental; Nitroso Compounds; Osteosarcoma; Rats; Sarcoma 180; Sarcoma 37; Sarcoma, Experimental; Urea; Urinary Bladder Neoplasms	1967
X-ray survival and DNA synthesis in Chinese hamster cells. I. The effect of inhibitors added before x-irradiation. Proceedings of the National Academy of Sciences of the United States of America, 1967, Volume: 58, Issue:1 Topics: Animals; Antifungal Agents; Antineoplastic Agents; Cell Division; Cricetinae; Culture Techniques; Cycloheximide; Dactinomycin; DNA; Hydroxyurea; Radiation Effects; Thymidine; Tritium; Urea	1967
Cultivation and properties of T-strains of mycoplasma associated with nongonococcal urethritis. Annals of the New York Academy of Sciences, 1967, Jul-28, Volume: 143, Issue:1 Topics: Culture Media; Deoxyuridine; Erythromycin; Humans; Hydroxyurea; Mycoplasma; Thallium; Urea; Urethritis	1967
Hydroxyurea derivatives: oxamyl hydroxamic acid. Cancer research, 1966, Volume: 26, Issue:11 Topics: Animals; Antineoplastic Agents; Bacterial Proteins; Carbon Isotopes; Carcinoma, Ehrlich Tumor; DNA, Bacterial; DNA, Neoplasm; Escherichia coli; Hydroxamic Acids; Hydroxyurea; In Vitro Techniques; Leucine; Methemoglobin; Mice; Microscopy, Electron; Neoplasm Proteins; RNA, Bacterial; RNA, Neoplasm; Spectrum Analysis; Thymidine; Tritium; Urea; Uridine	1966
Hydroxyurea derivatives: acetoxyoxamide. Journal of the National Cancer Institute, 1967, Volume: 38, Issue:1 Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; DNA, Bacterial; Escherichia coli; Hemoglobins; Hydroxyurea; In Vitro Techniques; Protein Biosynthesis; RNA, Bacterial; Urea	1967
The enzymatic reduction of hydroxyurea to urea by mouse liver. Cancer research, 1970, Volume: 30, Issue:5 Topics: Adenine Nucleotides; Animals; Carbon Isotopes; Cyanides; Cytochromes; Electrophoresis; Flavins; Hydroxyurea; In Vitro Techniques; Liver; Mice; Mitochondria, Liver; Nucleotides; Oxidation-Reduction; Paper; Pyridines; Spectrophotometry; Urea	1970
Urease inhibitors for hepatic coma. II. Comparative efficacy of four lower hydroxamate homologs in vitro and in vivo. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1970, Volume: 134, Issue:4 Topics: Acid-Base Equilibrium; Animals; Carbon Dioxide; Carbon Isotopes; Hepatic Encephalopathy; Hydroxamic Acids; Hydroxyurea; Male; Mice; Urea; Urease	1970
Anaflex and noxyflex: low-toxicity antiseptics. Drug and therapeutics bulletin, 1970, Oct-23, Volume: 8, Issue:20 Topics: Anti-Infective Agents, Local; Female; Formaldehyde; Humans; Hydroxyurea; Skin Diseases; Thiourea; Urea; Urinary Bladder Diseases; Vaginitis	1970
Urease catalysis. 3. Stoichiometry, kinetics, and inhibitory properties of a third substrate: dihydroxyurea. The Journal of biological chemistry, 1969, Mar-10, Volume: 244, Issue:5 Topics: Chemical Phenomena; Chemistry; Hydrogen-Ion Concentration; Hydroxyurea; Kinetics; Seeds; Urea; Urease	1969
Meso-alpha, beta-diphenylsuccinate and hydroxyurea as inhibitors of deoxycytidylate synthesis in extracts of Ehrlich ascites and L cells. The Journal of biological chemistry, 1966, Dec-25, Volume: 241, Issue:24 Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cytosine Nucleotides; Hydroxyurea; In Vitro Techniques; L Cells; Mice; Succinates; Urea	1966
Effect of hydroxyurea and related compounds on HMC mammary tumor growth and nucleic acids in Fischer rats. Cancer research, 1966, Volume: 26, Issue:11 Topics: Animals; Antineoplastic Agents; DNA, Neoplasm; Hydroxyurea; Male; Mammary Neoplasms, Experimental; Neoplasm Transplantation; Rats; RNA, Neoplasm; Urea	1966
Effects of hydroxyurea and related compounds on the blood and marrow of experimental animals. Cancer research, 1966, Volume: 26, Issue:11 Topics: Adrenal Glands; Animals; Antineoplastic Agents; Blood Cell Count; Blood Cells; Body Weight; Hydroxyurea; Leukemia L1210; Leukocytosis; Liver; Male; Mice; Neoplasm Transplantation; Organ Size; Rats; Seminal Vesicles; Testis; Thymus Gland; Urea	1966
Effect of hydroxyurea on growth of a transplantable mouse mammary adenocarcinoma. Cancer research, 1966, Volume: 26, Issue:11 Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Chorionic Gonadotropin; Female; Hydroxyprogesterones; Hydroxyurea; Mammary Neoplasms, Experimental; Mice; Necrosis; Neoplasm Transplantation; Testosterone; Urea	1966
Difference in the action of acriflavine and hydroxyurea on synthesis of macromolecules in a mammalian cell system in vitro. Experientia, 1966, Aug-15, Volume: 22, Issue:8 Topics: Acridines; Antineoplastic Agents; Carbon Isotopes; Culture Techniques; DNA; Humans; Hydroxyurea; Phenylalanine; RNA; Thymidine; Tritium; Urea; Uridine	1966
Hydroxyurea: effects on Chinese hamster cells grown in culture. Cancer research, 1967, Volume: 27, Issue:2 Topics: Animals; Antineoplastic Agents; Cell Division; Cricetinae; Culture Techniques; DNA; Hydroxyurea; Leucine; Radiation Effects; Thymidine; Tritium; Urea; Uridine	1967
Combined chemotherapy and radiotherapy. Preliminary results of clinical trial of hydroxyurea and x-irradiation in the treatment of epidermoid cancers of the head and neck. The American surgeon, 1967, Volume: 33, Issue:3 Topics: Adult; Antineoplastic Agents; Carcinoma, Squamous Cell; Female; Humans; Hydroxyurea; Male; Middle Aged; Mouth Neoplasms; Palatal Neoplasms; Tongue Neoplasms; Tonsillar Neoplasms; Urea	1967
Inhibition of DNA synthesis in HeLa cells by hydroxyurea. Cancer research, 1967, Volume: 27, Issue:1 Topics: Antineoplastic Agents; Cell Division; Culture Techniques; DNA; HeLa Cells; Humans; Hydroxyurea; Leucine; Protein Biosynthesis; RNA; Thymidine; Urea; Uridine	1967
Hydroxyurea. I. Acute cell death in proliferating tissues in rats. Cancer research, 1967, Volume: 27, Issue:1 Topics: Animals; Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Chromatography, Thin Layer; DNA; Duodenum; HeLa Cells; Hydroxamic Acids; Hydroxylamines; Hydroxyurea; Intestinal Mucosa; Intestine, Small; Rats; Thymidine; Thymus Gland; Urea; Urethane	1967
Hydroxyurea-induced inhibition of deoxyribonucleotide synthesis: studies in intact cells. Cancer research, 1967, Volume: 27, Issue:3 Topics: Antineoplastic Agents; Carbon Isotopes; Culture Techniques; DNA; Echinodermata; Embryo, Nonmammalian; HeLa Cells; Hydroxyurea; Leucine; Nucleosides; Nucleotides; Thymidine; Tritium; Urea; Uridine	1967
Inhibition of DNA synthesis by hydroxyurea: structure-activity relationships. Cancer research, 1967, Volume: 27, Issue:3 Topics: Antineoplastic Agents; Culture Techniques; DNA; Guanidines; HeLa Cells; Hydroxamic Acids; Hydroxylamines; Hydroxyurea; Leucine; Thymidine; Urea; Uridine	1967
Hydroxyurea reversal of inhibition and use as a cell-synchronizing agent. The Journal of biological chemistry, 1967, Mar-25, Volume: 242, Issue:6 Topics: Animals; Culture Techniques; DNA; Enzymes; Fibroblasts; Hydroxyurea; L Cells; Mice; Nucleosides; Nucleotides; Oxidative Phosphorylation; Oxidoreductases; Purines; Pyrimidines; Thymidine; Tritium; Urea	1967
Hydroxyurea in the management of head and neck cancer. II. Surgical aspects. Plastic and reconstructive surgery, 1967, Volume: 40, Issue:3 Topics: Antineoplastic Agents; Head; Head and Neck Neoplasms; Humans; Hydroxyurea; Mandibular Neoplasms; Neoplasms; Urea	1967
Noncovalent inhibitors of sickle hemoglobin gelation: effects of aliphatic alcohols, amides, and ureas. Biochemistry, 1980, Jul-08, Volume: 19, Issue:14 Topics: Alcohols; Amides; Gels; Hemoglobin, Sickle; Humans; Hydroxyurea; Kinetics; Protein Binding; Structure-Activity Relationship; Urea	1980
Inhibition of leukotriene B4 synthesis does not prevent development of acute renal failure following storage and transplantation. Transplantation, 1994, Dec-27, Volume: 58, Issue:12 Topics: Acute Kidney Injury; Animals; Capillary Permeability; Creatinine; Disease Models, Animal; Eicosanoids; Enzyme-Linked Immunosorbent Assay; Female; Graft Rejection; Graft Survival; Hydroxylamines; Hydroxyurea; Kidney Transplantation; Kidney Tubules; Leukotriene B4; Lipoxygenase Inhibitors; Methylurea Compounds; Necrosis; Organ Preservation; Prostaglandins F; Rabbits; Thromboxane B2; Urea	1994
Discovery of a novel class of potent HIV-1 protease inhibitors containing the (R)-(hydroxyethyl)urea isostere. Journal of medicinal chemistry, 1993, Jan-22, Volume: 36, Issue:2 Topics: Antiviral Agents; HIV Protease Inhibitors; Humans; Hydroxyurea; Stereoisomerism; Structure-Activity Relationship; Urea	1993
Determination of a new 5-lipoxygenase inhibitor, zileuton, and its inactive N-dehydroxylated metabolite in plasma by high performance liquid chromatography. Clinical pharmacokinetics, 1995, Volume: 29 Suppl 2 Topics: Animals; Calibration; Chromatography, High Pressure Liquid; Drug Stability; Haplorhini; Humans; Hydroxylation; Hydroxyurea; Lipoxygenase Inhibitors; Rats; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Stereoisomerism; Urea	1995
Identification of the human liver cytochrome P450 enzymes involved in the metabolism of zileuton (ABT-077) and its N-dehydroxylated metabolite, Abbott-66193. Drug metabolism and disposition: the biological fate of chemicals, 1995, Volume: 23, Issue:10 Topics: Cytochrome P-450 Enzyme System; Humans; Hydroxylation; Hydroxyurea; In Vitro Techniques; Isoenzymes; Lipoxygenase Inhibitors; Microsomes, Liver; Propranolol; Theophylline; Urea	1995
Aqueous stability of SB 210661: kinetics and primary degradation mechanisms of an N-hydroxyurea-containing 5-lipoxygenase inhibitor. The Journal of pharmacy and pharmacology, 1998, Volume: 50, Issue:2 Topics: Benzofurans; Drug Stability; Hydrogen-Ion Concentration; Hydroxyurea; Kinetics; Lipoxygenase Inhibitors; Urea; Water	1998
Urea uptake and urease activity in Corynebacterium glutamicum. Archives of microbiology, 1998, Volume: 169, Issue:5 Topics: Adenosine Triphosphate; Biological Transport; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Carrier Proteins; Corynebacterium; Hydroxyurea; Ionophores; Kinetics; Membrane Potentials; Mutation; Nitrogen; Proton-Motive Force; Thiourea; Urea; Urease; Valinomycin	1998
N-(Hydroxyaminocarbonyl)phenylalanine: a novel class of inhibitor for carboxypeptidase A. Bioorganic & medicinal chemistry, 2001, Volume: 9, Issue:1 Topics: Binding Sites; Binding, Competitive; Carboxypeptidases; Carboxypeptidases A; Drug Design; Enzyme Inhibitors; Hydroxyurea; Kinetics; Molecular Structure; Phenylalanine; Stereoisomerism; Urea	2001
Combined use of nonmyelosuppressive nitrosourea analogues with hydroxyurea in the induction of F-cell production in a human erythroleukemic cell line. Experimental hematology, 2003, Volume: 31, Issue:7 Topics: Cell Division; Fetal Hemoglobin; Humans; Hydroxyurea; K562 Cells; Leukemia, Erythroblastic, Acute; Monosaccharides; Urea	2003
A phase I study of hydroxyurea. Cancer chemotherapy reports, 1963, Volume: 29 Topics: Antineoplastic Agents; Humans; Hydroxyurea; Urea	1963
A method of analyzing for hydroxyurea in biological fluids. Cancer chemotherapy reports, 1963, Volume: 27 Topics: Antineoplastic Agents; Body Fluids; Feces; Humans; Hydroxyurea; Urea	1963
HYDROXYUREA: MECHANISM OF ACTION. Science (New York, N.Y.), 1963, Nov-22, Volume: 142, Issue:3595 Topics: Blood Chemical Analysis; Chromatography; Humans; Hydroxamic Acids; Hydroxyurea; Leukemia; Leukemia, Myeloid; Urea; Urine	1963
CYTOTOXICITY OF HYDROXYUREA (NSC-32065) REVERSIBLE BY PYRIMIDINE DEOXYRIBOSIDES IN A MAMMALIAN CELL LINE GROWN IN VITRO. Cancer chemotherapy reports, 1964, Volume: 34 Topics: Antimetabolites; Cell Line; Cricetinae; Hydroxyurea; In Vitro Techniques; Neoplasms; Neoplasms, Experimental; Nucleosides; Pyrimidine Nucleosides; Pyrimidines; Research; Thymidine; Tissue Culture Techniques; Urea	1964
TRIAL OF HYDROXYUREA (NSC-32065) IN CANCER IN CHILDREN. Cancer chemotherapy reports, 1964, Volume: 37 Topics: Antineoplastic Agents; Busulfan; Child; Cyclophosphamide; Dactinomycin; Humans; Hydroxyurea; Leukemia; Leukemia, Lymphoid; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Mercaptopurine; Neoplasms; Neuroblastoma; Sarcoma; Urea	1964
HYDROXYUREA. A NEW TYPE OF POTENTIAL ANTITUMOR AGENT. Journal of medicinal chemistry, 1963, Volume: 6 Topics: Animals; Antineoplastic Agents; Hydroxyurea; Leukemia; Leukemia L1210; Leukemia, Experimental; Mice; Pharmacology; Research; Urea	1963
EFFECT OF HYDROXYUREA ON PSEUDOMONAS AERUGINOSA. Cancer research, 1964, Volume: 24 Topics: DNA; DNA, Bacterial; Hydroxyurea; Metabolism; Pharmacology; Pseudomonas aeruginosa; Research; RNA; RNA, Bacterial; Urea	1964
HYDROXYUREA (NSC-32065)--A PHASE I STUDY. Cancer chemotherapy reports, 1964, Volume: 39 Topics: Antineoplastic Agents; Hydroxyurea; Toxicology; Urea	1964
HYDROXYUREA: INHIBITORY EFFECT ON DNA METABOLISM. Science (New York, N.Y.), 1964, Nov-27, Volume: 146, Issue:3648 Topics: Antineoplastic Agents; Cytosine Nucleotides; DNA; DNA, Neoplasm; Guanine Nucleotides; HeLa Cells; Humans; Hydroxyurea; Leucine; Neoplasms, Experimental; Nucleosides; Proteins; Research; RNA; Thymidine; Tissue Culture Techniques; Urea; Urethane; Uridine	1964
MEGALOBLASTIC ERYTHROPOIESIS INDUCED BY HYDROXYUREA (NSC-32065). Cancer chemotherapy reports, 1964, Volume: 40 Topics: Anemia; Anemia, Pernicious; Animals; Antineoplastic Agents; Bone Marrow Cells; Bone Marrow Diseases; Bone Marrow Examination; Dogs; Erythropoiesis; Hydroxyurea; Toxicology; Urea	1964
STUDIES ON A METABOLIC DEFECT INDUCED BY HYDROXYUREA (NSC-32065). Cancer chemotherapy reports, 1964, Volume: 40 Topics: Anemia; Anemia, Macrocytic; Animals; Antineoplastic Agents; Bone Marrow Cells; Cattle; Cytosine Nucleotides; DNA; gamma-Globulins; Hydroxyurea; Immunoglobulin G; Metabolic Diseases; Rats; Research; RNA; Serum Albumin; Serum Albumin, Bovine; Thymidine; Toxicology; Tritium; Urea	1964
PRELIMINARY SURVEY OF HYDROXYUREA (NSC-32065) AS A TERATOGEN. Cancer chemotherapy reports, 1964, Volume: 40 Topics: Abnormalities, Drug-Induced; Animals; Chick Embryo; Data Collection; Echinodermata; Embryo, Mammalian; Embryo, Nonmammalian; Hydroxyurea; Rats; Research; Teratogens; Toxicology; Urea	1964
STUDY OF SERUM B12 AND FOLATE IN PATIENTS TREATED WITH HYDROXYUREA (NSC-32065). Cancer chemotherapy reports, 1964, Volume: 40 Topics: Anemia; Anemia, Macrocytic; Antineoplastic Agents; Blood Chemical Analysis; Child; Folic Acid; Humans; Hydroxyurea; Toxicology; Urea; Vitamin B 12	1964
ERYTHROKINETIC ABNORMALITIES WITH ADMINISTRATION OF HYDROXYUREA (NSC-32065). Cancer chemotherapy reports, 1964, Volume: 40 Topics: Chromium Isotopes; Erythrocytes; Erythropoiesis; Humans; Hydroxyurea; Iron; Iron Isotopes; Toxicology; Urea	1964
ERYTHEMA IN AREAS OF PREVIOUS IRRADIATION IN PATIENTS TREATED WITH HYDROXYUREA (NSC-32065). Cancer chemotherapy reports, 1964, Volume: 40 Topics: Antineoplastic Agents; Drug Therapy; Erythema; Hydroxyurea; Neoplasms; Radiation Injuries; Toxicology; Urea	1964
HYDROXYUREA (NSC-32065): RESULTS OF A PHASE I STUDY. Cancer chemotherapy reports, 1964, Volume: 40 Topics: Anemia; Anemia, Aplastic; Antineoplastic Agents; Drug Therapy; Hydroxyurea; Leukopenia; Statistics as Topic; Thrombocytopenia; Toxicology; Urea	1964
PEDIATRIC CLINICAL TRIALS WITH HYDROXYUREA (NSC-32065). Cancer chemotherapy reports, 1964, Volume: 40 Topics: Adolescent; Antineoplastic Agents; Child; Drug Therapy; Hodgkin Disease; Hydroxyurea; Leukemia; Neoplasms; Neuroblastoma; Osteosarcoma; Sarcoma; Statistics as Topic; Teratoma; Thrombocytopenia; Toxicology; Urea	1964
PHASE II STUDIES OF HYDROXYUREA (NSC-32065) IN ADULTS: MISCELLANEOUS TUMORS. Cancer chemotherapy reports, 1964, Volume: 40 Topics: Adenocarcinoma; Antineoplastic Agents; Carcinoma, Hepatocellular; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Drug Therapy; Hydroxyurea; Leukopenia; Liver Neoplasms; Neoplasms; Neuroblastoma; Sarcoma; Toxicology; Urea	1964
PHASE II STUDIES OF HYDROXYUREA (NSC-32065) IN ADULTS: CANCER OF THE BREAST. Cancer chemotherapy reports, 1964, Volume: 40 Topics: Anemia; Anemia, Myelophthisic; Antineoplastic Agents; Breast Neoplasms; Drug Therapy; Erythema; Estrogens; Humans; Hydroxyurea; Neoplasms; Pigmentation Disorders; Radiation Injuries; Toxicology; Urea	1964
PHASE II STUDIES OF HYDROXYUREA (NSC-32065) IN ADULTS: CARCINOMA OF THE LUNG. Cancer chemotherapy reports, 1964, Volume: 40 Topics: Adult; Antineoplastic Agents; Carcinoma; Carcinoma, Squamous Cell; Drug Therapy; Humans; Hydroxyurea; Lung Neoplasms; Neoplasm Metastasis; Toxicology; Urea	1964
PHASE II STUDIES OF HYDROXYUREA (NSC-32065) IN ADULTS: LEUKEMIA. Cancer chemotherapy reports, 1964, Volume: 40 Topics: Antineoplastic Agents; Drug Therapy; Hydroxyurea; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Lymphocytes; Toxicology; Urea	1964
PHASE II STUDIES OF HYDROXYUREA (NSC-32065) IN ADULTS: MULTIPLE MYELOMA AND LYMPHOMA. Cancer chemotherapy reports, 1964, Volume: 40 Topics: Antineoplastic Agents; Drug Therapy; Hodgkin Disease; Hydroxyurea; Leukopenia; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Multiple Myeloma; Neoplasms; Sarcoma; Thrombocytopenia; Toxicology; Urea	1964
PHASE II STUDIES OF HYDROXYUREA (NSC-32065) IN ADULTS: CLINICAL EVALUATION. Cancer chemotherapy reports, 1964, Volume: 40 Topics: Antineoplastic Agents; Drug Therapy; Hodgkin Disease; Hydroxyurea; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Neoplasms; Sarcoma; Urea	1964
ANTILEUKEMIC ACTIVITY OF HYDROXYUREA (NSC-32065) AND OTHER UREA DERIVATIVES. Cancer chemotherapy reports, 1964, Volume: 40 Topics: Antineoplastic Agents; Biological Assay; Hydroxyurea; Leukemia; Leukemia, Experimental; Mice; Research; Statistics as Topic; Toxicology; Urea	1964
RENAL ABNORMALITIES INDUCED BY HYDROXYUREA (NSC-32065). Cancer chemotherapy reports, 1964, Volume: 40 Topics: Antineoplastic Agents; Blood; Hematologic Diseases; Hematuria; Hydroxyurea; Kidney Diseases; Kidney Function Tests; Kidney Tubules; Lymphoma; Toxicology; Urea; Uric Acid; Urine	1964
HYDROXYUREA ADMINISTERED INTERMITTENTLY. JAMA, 1965, Jun-28, Volume: 192 Topics: Antineoplastic Agents; Drug Therapy; Geriatrics; Hydroxyurea; Neoplasms; Toxicology; Urea	1965
UREASE CATALYSIS. I. STOICHIOMETRY, SPECIFICITY, AND KINETICS OF A SECOND SUBSTRATE: HYDROXYUREA. The Journal of biological chemistry, 1965, Volume: 240 Topics: Biochemical Phenomena; Biochemistry; Catalysis; Hydroxylamines; Hydroxyurea; Kinetics; Research; Urea; Urease	1965
UREASE CATALYSIS. II. INHIBITION OF THE ENZYME BY HYDROXYUREA, HYDROXYLAMINE, AND ACETOHYDROXAMIC ACID. The Journal of biological chemistry, 1965, Volume: 240 Topics: Catalysis; Enzyme Inhibitors; Hydroxamic Acids; Hydroxylamine; Hydroxylamines; Hydroxyurea; Kinetics; Research; Urea; Urease	1965
ACTIVITY OF CONGENERS OF HYDROXYUREA AGAINST ADVANCED LEUKEMIA L1210. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1965, Volume: 119 Topics: Animals; Guanidine; Guanidines; Hydrazines; Hydroxylamines; Hydroxyurea; Leukemia L1210; Mice; Pharmacology; Research; Selenium; Selenium Compounds; Thiourea; Urea; Urethane	1965
A SIMPLE METHOD OF COLORIMETRIC ANALYSIS FOR HYDROXYUREA (NSC-32065). Cancer chemotherapy reports, 1965, Volume: 46 Topics: Antineoplastic Agents; Colorimetry; Humans; Hydroxyurea; Urea	1965
A single aquaporin gene encodes a water/glycerol/urea facilitator in Toxoplasma gondii with similarity to plant tonoplast intrinsic proteins. FEBS letters, 2003, Dec-18, Volume: 555, Issue:3 Topics: Amino Acid Sequence; Animals; Aquaporins; Base Sequence; Glycerol; Hydroxyurea; Membrane Proteins; Molecular Sequence Data; Oocytes; Permeability; Phylogeny; Plant Proteins; Porins; Protozoan Proteins; Rats; Recombinant Proteins; Sequence Homology, Amino Acid; Toxoplasma; Urea; Water; Xenopus	2003
Analytical interference of hydroxyurea in the determination of urea, uric acid, and lactic acid. Analytical biochemistry, 2006, Oct-01, Volume: 357, Issue:1 Topics: Artifacts; False Positive Reactions; Humans; Hydroxyurea; Lactic Acid; Reference Standards; Urea; Uric Acid	2006
No effect of CYP450 and P-glycoprotein on hydroxyurea in vitro metabolism. Fundamental & clinical pharmacology, 2010, Volume: 24, Issue:1 Topics: Adenosine Triphosphatases; Antisickling Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Humans; Hydroxyurea; Microsomes, Liver; Time Factors; Urea	2010