urea has been researched along with dmp 323 in 29 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 19 (65.52) | 18.2507 |
| 2000's | 8 (27.59) | 29.6817 |
| 2010's | 2 (6.90) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bax, A; Grzesiek, S; Jadhav, PK; Kaufman, JD; Lam, PY; Nicholson, LK; Stahl, SJ; Torchia, DA; Wingfield, PT; Yamazaki, T | 1 |
| Cawood, PG; Erickson-Viitanen, S; Klabe, RM; Meek, JL; O'Neal, PL | 1 |
| Aldrich, PE; Cordova, BC; Jadhav, PK; Lam, PY; Meade, RP; Rayner, MM; Ru, Y | 1 |
| Campbell-Burk, S; Domaille, PJ; Kaufman, JD; Nicholson, LK; Stahl, SJ; Torchia, DA; Wingfield, PT; Yamazaki, T | 1 |
| Korant, BD | 1 |
| Bacheler, LT; De Lucca, GV; Jacobs, K; Jadhav, PK; Kaltenbach, RF; Klabe, RM; Meyer, DT; Nugiel, DA; Patel, M; Rayner, MM; Seitz, SP; Smyser, TE; Worley, T | 1 |
| Freedberg, DI; Kaufman, JD; Kiso, Y; Stahl, SJ; Torchia, DA; Wang, YX; Wingfield, PT; Yamazaki, T | 1 |
| Chang, CH; Freedberg, DI; Grzesiek, S; Hodge, CN; Kaufman, JD; Stahl, SJ; Torchia, DA; Wang, YX; Wingfield, PT | 1 |
| Chang, CH; Domaille, PJ; Hinck, AP; Kaufman, JD; Lam, PY; Nicholson, LK; Stahl, SJ; Torchia, DA; Wang, YX; Wingfield, P; Yamazaki, T | 1 |
| Ala, PJ; Chang, CH; DeLoskey, RJ; Duke, JL; Hodge, CN; Huston, EE; Klabe, RM; Korant, BD; Lam, PY; McCabe, DD; Rizzo, CJ | 1 |
| Aqvist, J; Bonham, NM; Bouzide, A; Classon, B; Danielson, UH; Hallberg, A; Hansson, T; Hultén, J; Karlén, A; Kvarnström, I; Nillroth, U; Samuelsson, B; Zuccarello, G | 1 |
| Chang, CH; Hodge, CN; Marrone, TJ; McCammon, JA; Resat, H | 1 |
| Ala, PJ; Chang, CH; DeLoskey, RJ; Duke, JL; Eyermann, CJ; Hodge, CN; Huston, EE; Jadhav, PK; Lam, PY; Lewandowski, FA; McCabe, DD; Schadt, MC; Weber, PC | 1 |
| Bacheler, LT; Cordova, B; De Lucca, GV; Erickson-Viitanen, S; Garber, S; Kim, UT; Klabe, RM; Ko, SS; Lam, GN; Liang, J; Logue, KA; Trainor, GL; Wright, MR | 1 |
| Aungst, BJ; De Lucca, GV; Erickson-Viitanen, S; Jadhav, PK; Lam, PY; Waltermire, RE | 1 |
| Ala, PJ; Chang, CH; Huston, EE; Jadhav, PK; Klabe, RM; Lam, PY | 1 |
| Bacheler, LT; Cordova, BC; Erickson-Viitanen, S; Klabe, RM; Patel, M; Rayner, MM; Seitz, SP | 1 |
| Ishima, R; Louis, JM; Torchia, DA | 1 |
| Freedberg, DI; Ishima, R; Louis, JM; Torchia, DA; Wang, YX | 1 |
| De Lucca, GV; Duan, Y; Klabe, RM; Kollman, PA; Stouten, P; Wang, L | 1 |
| Ghirlando, R; Gronenborn, AM; Ishima, R; Louis, JM; Torchia, DA; Tözsér, J | 1 |
| Bagossi, P; Boross, P; Copeland, TD; Fehér, A; Harrison, RW; Louis, JM; Mahalingam, B; Torshin, IY; Tözsér, J; Weber, IT | 1 |
| Hanson, PR; McReynolds, MD; Sprott, KT | 1 |
| Hylton, KG; Main, AD; McElwee-White, L | 1 |
| Gyémánt, N; Hilgeroth, A; Molnár, J; Richter, M | 1 |
| Sussman, F; Vilar, S; Villaverde, MC | 1 |
| Ishikita, H; Warshel, A | 1 |
| Frushicheva, MP; Singh, N; Warshel, A | 1 |
| Li, P; Wang, H; Wang, S; Yan, H | 1 |
1 review(s) available for urea and dmp 323
| Article | Year |
|---|---|
De novo design and discovery of cyclic HIV protease inhibitors capable of displacing the active-site structural water molecule.
Topics: Animals; Azepines; Binding Sites; Drug Design; HIV Protease; HIV Protease Inhibitors; Humans; Molecular Conformation; Urea | 1998 |
28 other study(ies) available for urea and dmp 323
| Article | Year |
|---|---|
Flexibility and function in HIV-1 protease.
Topics: Amino Acid Sequence; Azepines; Binding Sites; HIV Protease; HIV Protease Inhibitors; Isoleucine; Kinetics; Magnetic Resonance Spectroscopy; Models, Molecular; Nitrogen Isotopes; Protein Conformation; Recombinant Proteins; Urea | 1995 |
Potency and selectivity of inhibition of human immunodeficiency virus protease by a small nonpeptide cyclic urea, DMP 323.
Topics: Amino Acid Sequence; Aspartic Acid Endopeptidases; Azepines; Blood; Chymotrypsin; HIV Protease; HIV Protease Inhibitors; HIV-1; HIV-2; Humans; Kinetics; Molecular Sequence Data; Substrate Specificity; Urea | 1994 |
DMP 323, a nonpeptide cyclic urea inhibitor of human immunodeficiency virus (HIV) protease, specifically and persistently blocks intracellular processing of HIV gag polyprotein.
Topics: Azepines; Cells, Cultured; Gene Products, gag; HIV Protease Inhibitors; HIV-1; Humans; Microscopy, Electron; Protein Processing, Post-Translational; RNA, Viral; Urea; Virus Replication | 1994 |
Secondary structure and signal assignments of human-immunodeficiency-virus-1 protease complexed to a novel, structure-based inhibitor.
Topics: Amino Acid Sequence; Azepines; Cloning, Molecular; Escherichia coli; HIV Protease; HIV Protease Inhibitors; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Mutagenesis, Site-Directed; Point Mutation; Protein Binding; Protein Structure, Secondary; Recombinant Proteins; Urea | 1994 |
Inhibitor-resistant mutants of the HIV-1 aspartic protease.
Topics: Azepines; Cloning, Molecular; Drug Resistance, Microbial; Escherichia coli; HIV Protease; HIV Protease Inhibitors; Humans; Kinetics; Mutagenesis; Recombinant Proteins; Urea | 1995 |
Preparation and structure-activity relationship of novel P1/P1'-substituted cyclic urea-based human immunodeficiency virus type-1 protease inhibitors.
Topics: Azepines; Binding Sites; Cell Line; Cell Survival; Crystallography, X-Ray; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Models, Molecular; Molecular Structure; Protein Binding; Structure-Activity Relationship; Urea | 1996 |
Solution NMR evidence that the HIV-1 protease catalytic aspartyl groups have different ionization states in the complex formed with the asymmetric drug KNI-272.
Topics: Amino Acid Sequence; Aspartic Acid; Azepines; Binding Sites; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Kinetics; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Structure; Mutagenesis, Site-Directed; Oligopeptides; Point Mutation; Protein Conformation; Recombinant Proteins; Urea | 1996 |
Mapping hydration water molecules in the HIV-1 protease/DMP323 complex in solution by NMR spectroscopy.
Topics: Azepines; HIV Protease; HIV Protease Inhibitors; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Recombinant Proteins; Urea; Water | 1996 |
Three-dimensional solution structure of the HIV-1 protease complexed with DMP323, a novel cyclic urea-type inhibitor, determined by nuclear magnetic resonance spectroscopy.
Topics: Azepines; Escherichia coli; HIV Protease; HIV Protease Inhibitors; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Molecular Structure; Mutagenesis, Site-Directed; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Protons; Recombinant Proteins; Urea; Viral Proteins | 1996 |
Molecular basis of HIV-1 protease drug resistance: structural analysis of mutant proteases complexed with cyclic urea inhibitors.
Topics: Azepines; Binding Sites; Crystallography, X-Ray; Drug Resistance, Microbial; HIV Protease; HIV Protease Inhibitors; Kinetics; Molecular Sequence Data; Mutagenesis, Insertional; Protein Conformation; Structure-Activity Relationship; Urea | 1997 |
Cyclic HIV-1 protease inhibitors derived from mannitol: synthesis, inhibitory potencies, and computational predictions of binding affinities.
Topics: Anti-HIV Agents; Azepines; Computer Simulation; HIV Protease; HIV Protease Inhibitors; HIV-1; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Mannitol; Molecular Structure; Protein Binding; Sulfonamides; Urea | 1997 |
Solvation studies of DMP323 and A76928 bound to HIV protease: analysis of water sites using grand canonical Monte Carlo simulations.
Topics: Alcohols; Azepines; HIV Protease; HIV Protease Inhibitors; HIV-1; Hydrogen Bonding; Models, Molecular; Monte Carlo Method; Protein Binding; Protein Structure, Tertiary; Solvents; Urea; Water | 1998 |
Molecular recognition of cyclic urea HIV-1 protease inhibitors.
Topics: Anti-HIV Agents; Azepines; HIV Protease; HIV Protease Inhibitors; HIV-1; Hydrogen Bonding; Molecular Conformation; Urea | 1998 |
Nonsymmetric P2/P2' cyclic urea HIV protease inhibitors. Structure-activity relationship, bioavailability, and resistance profile of monoindazole-substituted P2 analogues.
Topics: Administration, Oral; Animals; Anti-HIV Agents; Azepines; Biological Availability; Cell Line; Chromatography, High Pressure Liquid; Dogs; Drug Design; Drug Resistance, Microbial; HIV Protease Inhibitors; HIV-1; Indazoles; Mutation; Ritonavir; RNA, Viral; Structure-Activity Relationship; Transcription, Genetic; Urea | 1998 |
Counteracting HIV-1 protease drug resistance: structural analysis of mutant proteases complexed with XV638 and SD146, cyclic urea amides with broad specificities.
Topics: Amino Acid Substitution; Azepines; Binding Sites; Drug Resistance, Microbial; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Macromolecular Substances; Models, Molecular; Mutagenesis, Site-Directed; Substrate Specificity; Urea | 1998 |
The synthesis and evaluation of cyclic ureas as HIV protease inhibitors: modifications of the P1/P1' residues.
Topics: Antiviral Agents; Azepines; HIV; HIV Protease; HIV Protease Inhibitors; Indicators and Reagents; Kinetics; Molecular Structure; Structure-Activity Relationship; Urea | 1998 |
Transverse 1H cross relaxation in 1H-15N correlated 1H CPMG experiments.
Topics: Amides; Azepines; Binding Sites; HIV Protease; Magnetic Resonance Spectroscopy; Molecular Structure; Nitrogen Isotopes; Protons; Spin Labels; Urea | 1999 |
Flap opening and dimer-interface flexibility in the free and inhibitor-bound HIV protease, and their implications for function.
Topics: Azepines; Dimerization; HIV Protease; HIV Protease Inhibitors; Magnetic Resonance Spectroscopy; Models, Molecular; Mutation; Nitrogen Isotopes; Protein Conformation; Urea | 1999 |
Does a diol cyclic urea inhibitor of HIV-1 protease bind tighter than its corresponding alcohol form? A study by free energy perturbation and continuum electrostatics calculations.
Topics: Azepines; Binding Sites; HIV Protease Inhibitors; In Vitro Techniques; Models, Molecular; Static Electricity; Thermodynamics; Urea | 2001 |
Folded monomer of HIV-1 protease.
Topics: Amino Acid Sequence; Azepines; Dimerization; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Models, Molecular; Molecular Sequence Data; Mutation; Nuclear Magnetic Resonance, Biomolecular; Protein Conformation; Protein Folding; Structure-Activity Relationship; Urea | 2001 |
Effect of sequence polymorphism and drug resistance on two HIV-1 Gag processing sites.
Topics: Amino Acid Sequence; Amino Acid Substitution; Azepines; Binding Sites; Carbamates; Catalysis; Drug Resistance, Viral; Furans; Gene Products, gag; Genes, gag; HIV Protease; HIV Protease Inhibitors; HIV-1; Kinetics; Models, Molecular; Molecular Sequence Data; Oligopeptides; Polymorphism, Genetic; Protein Conformation; Substrate Specificity; Sulfonamides; Urea | 2002 |
A concise route to structurally diverse DMP 323 analogues via highly functionalized 1,4-diamines.
Topics: Alcohols; Azepines; Diamines; Heterocyclic Compounds; HIV Protease Inhibitors; Urea | 2002 |
Catalytic carbonylation of functionalized diamines: application to the core structure of DMP 323 and DMP 450.
Topics: Azepines; Carbon Compounds, Inorganic; Catalysis; Diamines; HIV Protease Inhibitors; Molecular Structure; Tungsten; Urea | 2003 |
P-glycoprotein effects of cyclic urea HIV protease inhibitor DMP 323 in competitional absorption studies.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; Azepines; Cell Line, Tumor; HIV Protease Inhibitors; Intestinal Absorption; Male; Mice; Permeability; Rats; Rats, Wistar; Ritonavir; Urea | 2006 |
Inhibitor docking screened by the modified SAFE_p scoring function: application to cyclic urea HIV-1 PR inhibitors.
Topics: Algorithms; Amino Acids; Azepines; Binding Sites; Computer Simulation; HIV Protease; HIV Protease Inhibitors; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Molecular Structure; Protein Binding; Static Electricity; Thermodynamics; Urea | 2007 |
Predicting drug-resistant mutations of HIV protease.
Topics: Azepines; Binding Sites; Catalysis; Computer Simulation; Drug Resistance, Viral; HIV Protease; HIV Protease Inhibitors; Models, Chemical; Molecular Structure; Mutation; Static Electricity; Structure-Activity Relationship; Thermodynamics; Urea | 2008 |
Validating the vitality strategy for fighting drug resistance.
Topics: Antiviral Agents; Azepines; Carrier Proteins; Catalytic Domain; Computational Biology; Computer Simulation; Databases, Factual; Drug Resistance, Viral; Enzyme Activation; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Indinavir; Ligands; Molecular Structure; Static Electricity; Thermodynamics; Urea | 2012 |
Synthesis and Biological Evaluation of 3,9-Dioxatetraasteranes as C
Topics: Azepines; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Inhibitory Concentration 50; Models, Molecular; Molecular Docking Simulation; Structure-Activity Relationship; Urea; Urease | 2019 |