Compounds > urea

urea and birb 796

urea has been researched along with birb 796 in 5 studies

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (40.00)29.6817
2010's3 (60.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Breitfelder, S; Cirillo, P; Gilmore, T; Graham, AG; Hickey, E; Klaus, B; Madwed, J; Moriak, M; Moss, N; Pargellis, C; Pav, S; Proto, A; Regan, J; Swinamer, A; Tong, L; Torcellini, C1
Capolino, A; Cirillo, PF; Gilmore, T; Graham, AG; Hickey, E; Kroe, RR; Madwed, J; Moriak, M; Moss, N; Nelson, R; Pargellis, CA; Regan, J; Swinamer, A; Torcellini, C; Tsang, M1
Aoki, T; Arai, T; Hayashi, S; Hirokawa, H; Inoue, H; Kainoh, M; Kawai, H; Koga, Y; Meguro, H; Ohno, M; Oshida, K; Suyama, K1
Barreiro, EJ; da Silva, LL; de Lima, CK; Fraga, CA; Lacerda, RB; Laufer, SA; Miguez, E; Miranda, AL1
Aungier, SR; Cartwright, AJ; Ito, K; Midwood, KS; To, WS1

Other Studies

5 other study(ies) available for urea and birb 796

ArticleYear
Pyrazole urea-based inhibitors of p38 MAP kinase: from lead compound to clinical candidate.
    Journal of medicinal chemistry, 2002, Jul-04, Volume: 45, Issue:14

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding, Competitive; Cell Line; Chromatography, High Pressure Liquid; Crystallography, X-Ray; Enzyme Inhibitors; Female; Fluorescence; Humans; Lipopolysaccharides; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; Models, Molecular; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Protein Binding; Pyrazoles; Structure-Activity Relationship; Tumor Necrosis Factor-alpha; Urea

2002
Structure-activity relationships of the p38alpha MAP kinase inhibitor 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naph- thalen-1-yl]urea (BIRB 796).
    Journal of medicinal chemistry, 2003, Oct-23, Volume: 46, Issue:22

    Topics: Animals; Cell Line; Crystallography, X-Ray; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Heating; Humans; In Vitro Techniques; Ligands; Lipopolysaccharides; Mice; Mitogen-Activated Protein Kinase 14; Mitogen-Activated Protein Kinases; Naphthalenes; Protein Binding; Protein Denaturation; Pyrazoles; Structure-Activity Relationship; Tumor Necrosis Factor-alpha; Urea

2003
Design and synthesis of novel p38α MAP kinase inhibitors: discovery of pyrazole-benzyl ureas bearing 2-molpholinopyrimidine moiety.
    Bioorganic & medicinal chemistry letters, 2012, Aug-01, Volume: 22, Issue:15

    Topics: Administration, Oral; Animals; Binding Sites; Crystallography, X-Ray; Cytochrome P-450 Enzyme System; Drug Design; Drug Evaluation, Preclinical; Humans; Imidazoles; Lipopolysaccharides; Liver; Mice; Mitogen-Activated Protein Kinase 14; Naphthalenes; Protein Kinase Inhibitors; Protein Structure, Tertiary; Pyrazoles; Pyridines; Pyrimidines; Tumor Necrosis Factor-alpha; Urea

2012
Discovery of novel orally active anti-inflammatory N-phenylpyrazolyl-N-glycinyl-hydrazone derivatives that inhibit TNF-α production.
    PloS one, 2012, Volume: 7, Issue:10

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Design; Female; Hydrazones; Male; Mice; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Pyrazoles; Rats; Tumor Necrosis Factor-alpha; Urea

2012
Potent anti-inflammatory effects of the narrow spectrum kinase inhibitor RV1088 on rheumatoid arthritis synovial membrane cells.
    British journal of pharmacology, 2015, Volume: 172, Issue:15

    Topics: Acetamides; Adalimumab; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Dasatinib; Dose-Response Relationship, Drug; Humans; Inflammation Mediators; Interleukin-6; Interleukin-8; Macrophages; Monocytes; Naphthalenes; Oxazines; Piperidines; Primary Cell Culture; Protein Kinase Inhibitors; Pyrazoles; Pyridines; Pyrimidines; Pyrroles; RNA, Small Interfering; Signal Transduction; Synovial Membrane; Tumor Necrosis Factor-alpha; Urea

2015