urea and adozelesin

urea has been researched along with adozelesin in 12 studies

Research

Studies (12)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	6 (50.00)	18.2507
2000's	6 (50.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Baker, RM; Beerman, TA; Meegan, RL; Woynarowski, JM; Zsido, TJ	1
Gibson, NW; Lee, CS	1
Ames, MM; Reid, JM; Walker, DL	1
Gibson, NW; Lee, CS; Pfeifer, GP	1
Angioli, R; Averette, H; Hightower, RD; Nguyen, H; Perras, J; Sevin, BU; Untch, M	1
Cerna, C; Gomez, L; Hidalgo, M; Izbicka, E; Rowinsky, EK; Von Hoff, DD; Weitman, SD	1
Arnett, B; Napier, C; Trevino, AV; Woynarowski, JM	1
Koba, M; Konopa, J; Skladanowski, A	1
Woynarowski, JM	1
Beerman, T; Cao, PR; McHugh, MM; Melendy, T	1
Bai, S; Goodrich, DW	1
Ginsburg, H; Krugliak, M; Woynarowski, JM	1

Reviews

1 review(s) available for urea and adozelesin

Article	Year
Targeting critical regions in genomic DNA with AT-specific anticancer drugs. Biochimica et biophysica acta, 2002, Jul-18, Volume: 1587, Issue:2-3 Topics: Antineoplastic Agents; Base Sequence; Benzofurans; Binding Sites; Cyclohexanecarboxylic Acids; Cyclohexenes; Distamycins; DNA Damage; DNA, Neoplasm; Drug Design; Duocarmycins; Genome, Human; Humans; Indoles; Nitrogen Mustard Compounds; Tandem Repeat Sequences; Tumor Cells, Cultured; Urea	2002

Article

Year

Targeting critical regions in genomic DNA with AT-specific anticancer drugs.

Biochimica et biophysica acta, 2002, Jul-18, Volume: 1587, Issue:2-3

Topics: Antineoplastic Agents; Base Sequence; Benzofurans; Binding Sites; Cyclohexanecarboxylic Acids; Cyclohexenes; Distamycins; DNA Damage; DNA, Neoplasm; Drug Design; Duocarmycins; Genome, Human; Humans; Indoles; Nitrogen Mustard Compounds; Tandem Repeat Sequences; Tumor Cells, Cultured; Urea

2002

Other Studies

11 other study(ies) available for urea and adozelesin

Article	Year
Resistance of CHO cells expressing P-glycoprotein to cyclopropylpyrroloindole (CPI) alkylating agents. Biochemical pharmacology, 1992, Apr-15, Volume: 43, Issue:8 Topics: Alkylating Agents; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzofurans; Cell Line; Cell Survival; CHO Cells; Cricetinae; Cricetulus; Cyclohexanecarboxylic Acids; Cyclohexenes; DNA Damage; Drug Resistance; Duocarmycins; Indoles; Leucomycins; Membrane Glycoproteins; Urea	1992
DNA damage and differential cytotoxicity produced in human carcinoma cells by CC-1065 analogues, U-73,975 and U-77,779. Cancer research, 1991, Dec-15, Volume: 51, Issue:24 Topics: Antibiotics, Antineoplastic; Benzofurans; Carcinoma; Cell Death; Colonic Neoplasms; Cross-Linking Reagents; Cyclohexanecarboxylic Acids; Cyclohexenes; DNA Damage; Dose-Response Relationship, Drug; Duocarmycins; Humans; Indoles; Leucomycins; Lung Neoplasms; Plasmids; Tumor Cells, Cultured; Urea	1991
Preclinical pharmacology of bizelesin, a potent bifunctional analog of the DNA-binding antibiotic CC-1065. Cancer chemotherapy and pharmacology, 1994, Volume: 34, Issue:4 Topics: Alkylating Agents; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Benzofurans; Chromatography, High Pressure Liquid; Cyclohexanecarboxylic Acids; Cyclohexenes; Duocarmycins; Indoles; Leucomycins; Leukemia L1210; Male; Mice; Mice, Inbred Strains; Urea	1994
Mapping of DNA alkylation sites induced by adozelesin and bizelesin in human cells by ligation-mediated polymerase chain reaction. Biochemistry, 1994, May-17, Volume: 33, Issue:19 Topics: Alkylating Agents; Base Sequence; Benzofurans; Cyclohexanecarboxylic Acids; Cyclohexenes; DNA; Duocarmycins; Genes, p53; Humans; Indoles; Molecular Sequence Data; Phosphoglycerate Kinase; Polymerase Chain Reaction; Tumor Cells, Cultured; Urea	1994
In vitro evaluation of the novel chemotherapeutic agents U-73,975, U-77,779, and U-80,244 in gynecologic cancer cell lines. Cancer investigation, 1993, Volume: 11, Issue:3 Topics: Adenosine Triphosphate; Antineoplastic Agents; Benzofurans; Cisplatin; Cyclohexanecarboxylic Acids; Cyclohexenes; Dose-Response Relationship, Drug; Doxorubicin; Drug Screening Assays, Antitumor; Duocarmycins; Endometrial Neoplasms; Female; Humans; In Vitro Techniques; Indoles; Ovarian Neoplasms; Tumor Cells, Cultured; Urea; Uterine Cervical Neoplasms	1993
Comparative activity of the cyclopropylpyrroloindole compounds adozelesin, bizelesin and carzelesin in a human tumor colony-forming assay. Anti-cancer drugs, 1999, Volume: 10, Issue:3 Topics: Antineoplastic Agents; Benzofurans; Cyclohexanecarboxylic Acids; Cyclohexenes; Drug Screening Assays, Antitumor; Duocarmycins; Humans; Indoles; Tumor Cells, Cultured; Urea	1999
Region-specific DNA damage by AT-specific DNA-reactive drugs is predicted by drug binding specificity. Biochemistry, 2000, Aug-15, Volume: 39, Issue:32 Topics: Alu Elements; Antineoplastic Agents, Alkylating; Apolipoproteins B; AT Rich Sequence; Benzofurans; Binding Sites; Cyclohexanecarboxylic Acids; Cyclohexenes; DNA; DNA Adducts; DNA Damage; DNA, Mitochondrial; Duocarmycins; Genome, Human; Globins; Humans; Hypoxanthine Phosphoribosyltransferase; Indoles; Nuclear Matrix; Polymerase Chain Reaction; Proto-Oncogene Proteins c-myc; Replication Origin; Tumor Cells, Cultured; Urea	2000
Does the antitumor cyclopropylpyrroloindole antibiotic CC-1065 cross-link DNA in tumor cells? Biochemical pharmacology, 2001, Jan-01, Volume: 61, Issue:1 Topics: Antibiotics, Antineoplastic; Benzofurans; Cell Division; Cross-Linking Reagents; Cyclohexanecarboxylic Acids; Cyclohexenes; DNA; DNA, Neoplasm; Duocarmycins; HeLa Cells; Humans; Indoles; Leucomycins; Urea	2001
The DNA minor groove-alkylating cyclopropylpyrroloindole drugs adozelesin and bizelesin induce different DNA damage response pathways in human colon carcinoma HCT116 cells. Molecular cancer therapeutics, 2003, Volume: 2, Issue:7 Topics: Antineoplastic Agents, Alkylating; Apoptosis; Benzofurans; Cell Cycle; Cellular Senescence; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cyclohexanecarboxylic Acids; Cyclohexenes; DNA Damage; DNA, Neoplasm; Dose-Response Relationship, Drug; Duocarmycins; Humans; Indoles; Signal Transduction; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Urea	2003
Different DNA lesions trigger distinct cell death responses in HCT116 colon carcinoma cells. Molecular cancer therapeutics, 2004, Volume: 3, Issue:5 Topics: Aminoglycosides; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Benzofurans; Cell Cycle; Cell Death; Cell Proliferation; Colonic Neoplasms; Cyclohexanecarboxylic Acids; Cyclohexenes; DNA Damage; Dose-Response Relationship, Drug; Duocarmycins; Enediynes; HCT116 Cells; Humans; Indoles; Inhibitory Concentration 50; Urea	2004
Pharmacogenomic analyses of targeting the AT-rich malaria parasite genome with AT-specific alkylating drugs. Molecular and biochemical parasitology, 2007, Volume: 154, Issue:1 Topics: Alkylating Agents; Animals; Antimalarials; Base Composition; Benzofurans; Binding Sites; Centromere; Cyclohexanecarboxylic Acids; Cyclohexenes; DNA, Protozoan; Duocarmycins; Genomic Islands; Humans; Indoles; Inhibitory Concentration 50; Molecular Structure; Parasitic Sensitivity Tests; Pharmacogenetics; Plasmodium falciparum; Sensitivity and Specificity; Urea	2007