urea has been researched along with act 058362 in 30 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 16 (53.33) | 29.6817 |
| 2010's | 14 (46.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Binkert, C; Birker-Robaczewska, M; Boukhadra, C; Clozel, M; Ding, SS; Fischli, W; Hess, P; Mathys, B; Morrison, K; Müller, C; Nayler, O; Qiu, C; Rey, M; Scherz, MW; Velker, J; Weller, T; Xi, JF; Ziltener, P | 1 |
| Chao, BB; Peng, YP; Qiu, YH; Wang, JJ | 1 |
| Clozel, M; Ding, SS; Hess, P; Qiu, C; Rey, M | 1 |
| Albertin, G; Casale, V; Malendowicz, LK; Nussdorfer, GG; Rossi, GP; Spinazzi, R; Ziolkowska, A | 1 |
| Bohnemeier, H; Chadha-Boreham, H; Dingemanse, J; Halabi, A; Jungnik, A; Krähenbühl, S; Sidharta, PN; Wagner, FD | 1 |
| Batuwangala, M; Lambert, DG; McDonald, J | 1 |
| Forster, ME; Pemberton, CJ; Prosser, HC; Richards, AM | 1 |
| Egido, EM; Hernández, R; Marco, J; Silvestre, RA | 1 |
| Tölle, M; van der Giet, M | 1 |
| Alcain, FJ; Castaño, JP; Duran-Prado, M; Gahete, MD; Leprince, J; Malagon, MM; Martinez-Fuentes, AJ; Molina, M; Tonon, MC; Vaudry, H; Vazquez-Martinez, R | 1 |
| Biecker, E; Clemens, C; Eckhardt, A; Fischer, N; Heller, J; Hennenberg, M; Lammert, F; Leifeld, L; Pröbsting, AS; Sauerbruch, T; Trebicka, J | 1 |
| Cosenzi, A | 1 |
| Aiyar, NV; Behm, DJ; Dodson, JW; Douglas, SA; Evans, CA; Fries, HE; Harrison, SM; Hernandez, RR; Hoffman, KD; Lai, JM; McAtee, JJ; Neeb, MJ; Ohlstein, EH; Wu, C | 1 |
| Albertin, G; Antonello, M; Guidolin, D; Mascarin, A; Montopoli, M; Oselladore, B; Ribatti, D; Sorato, E; Spinazzi, R | 1 |
| Dingemanse, J; Sidharta, PN; van Giersbergen, PL | 1 |
| Penny, DJ; Shekerdemian, LS; Simpson, CM; Smolich, JJ | 1 |
| Chiossi, E; Dingemanse, J; Heinemann, L; Krähenbühl, S; Rave, K; Sidharta, PN | 1 |
| Chadha-Boreham, H; Chiurchiu, C; Danaietash, P; de Zeeuw, D; Dingemanse, J; Hadjadj, S; Krum, H; Navis, G; Neuhart, E; Parvanova, AI; Remuzzi, G; Ruggenenti, P; Vogt, L; Woittiez, AJ; Zimlichman, R | 1 |
| Bianchini, P; Bruzzone, F; Cervetto, C; Diaspro, A; Leprince, J; Marcoli, M; Maura, G; Mazzotta, MC; Ronzitti, E; Vallarino, M; Vaudry, H | 1 |
| Abrol, R; Goddard, WA; Kim, SK; Li, Y; Park, C | 1 |
| Ceribasi, AO; Demir, T; Kaplan, DS; Kisacik, B; Onat, AM; Pehlivan, Y; Taysi, S; Turkbeyler, IH; Tutar, E | 1 |
| Biller, BM; Findling, JW; Fleseriu, M; Gross, C; Molitch, ME; Schteingart, DE | 1 |
| Aksoy, N; Ceribasi, AO; Demir, T; Kaplan, DS; Kisacik, B; Onat, AM; Orkmez, M; Pehlivan, Y; Taysi, S; Türkbeyler, I | 1 |
| Bagcı, C; Demir, T; Kaplan, DS; Kisacik, B; Onat, AM; Orkmez, M; Pehlivan, Y; Taysi, S; Turkbeyler, I; Tutar, E | 1 |
| Ceribasi, AO; Demir, T; Kaplan, DS; Kisacik, B; Onat, AM; Orkmez, M; Pehlivan, Y; Sayarlioglu, M; Taysi, S; Turkbeyler, IH; Tutar, E | 1 |
| Ceribasi, AO; Demir, T; Dokuyucu, R; Kaplan, DS; Kisacik, B; Koc, I; Onat, AM; Orkmez, M; Pehlivan, Y; Taysi, S; Turkbeyler, IH; Tutar, E | 1 |
| Goddard, WA; Kim, SK; Lee, BH; Lim, CJ; Trzaskowski, B; Yi, KY | 1 |
| Akpinar, E; Cadirci, E; Cinar, I; Dincer, B; Gundogdu, B; Halici, Z; Ugan, RA | 1 |
| Dingemanse, J; Sidharta, PN; van Giersbergen, PLM | 1 |
| Can, C; Çavuşoğlu, T; Çelenk, FG; Coşkunsever, D; Duman, S; Olukman, M; Sözmen, E; Ülker, S; Uyanikgil, Y | 1 |
3 review(s) available for urea and act 058362
| Article | Year |
|---|---|
Role of urotensin II and its receptor in health and disease.
Topics: Animals; Calcium; Cricetinae; Cricetulus; Diabetes Mellitus; Heart Failure; Humans; Hypertension; Intracellular Signaling Peptides and Proteins; Mice; Mice, Knockout; Polymerase Chain Reaction; Quinolines; Rats; Receptors, G-Protein-Coupled; Renal Insufficiency; Signal Transduction; Urea; Urotensins; Vasoconstriction | 2007 |
Cardiorenovascular effects of urotensin II and the relevance of the UT receptor.
Topics: Animals; Cardiovascular System; Heart Diseases; Humans; Kidney; Kidney Diseases; Myocardium; Quinolines; Receptors, G-Protein-Coupled; Tissue Distribution; Urea; Urotensins; Vasoconstriction; Vasodilation | 2008 |
Non peptidic urotensin II antagonists: perspectives for a new class of drugs.
Topics: Animals; Drug Design; Humans; Pyrrolidines; Quinolines; Sulfonamides; Urea; Urotensins | 2008 |
6 trial(s) available for urea and act 058362
| Article | Year |
|---|---|
Pharmacodynamics and pharmacokinetics of the urotensin II receptor antagonist palosuran in macroalbuminuric, diabetic patients.
Topics: Aged; Albuminuria; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Area Under Curve; Creatinine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Fatigue; Female; Glomerular Filtration Rate; Headache; Humans; Hypertension; Male; Middle Aged; Nasopharyngitis; Quinolines; Receptors, G-Protein-Coupled; Renal Circulation; Treatment Outcome; Urea | 2006 |
Pharmacokinetics and pharmacodynamics of the urotensin-II receptor antagonist palosuran in healthy male subjects.
Topics: Adult; Creatinine; Dose-Response Relationship, Drug; Humans; Male; Middle Aged; Potassium; Quinolines; Receptors, G-Protein-Coupled; Sodium; Time Factors; Urea; Urotensins | 2009 |
Effect of the urotensin-II receptor antagonist palosuran on secretion of and sensitivity to insulin in patients with Type 2 diabetes mellitus.
Topics: Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Glucose Clamp Technique; Glucose Tolerance Test; Humans; Insulin; Insulin Secretion; Male; Middle Aged; Quinolines; Receptors, G-Protein-Coupled; Treatment Outcome; Urea; Urotensins | 2009 |
Effect of the urotensin receptor antagonist palosuran in hypertensive patients with type 2 diabetic nephropathy.
Topics: Adult; Aged; Albuminuria; Antihypertensive Agents; Blood Pressure; Creatinine; Cross-Over Studies; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Humans; Hypertension; Male; Middle Aged; Placebos; Quinolines; Receptors, G-Protein-Coupled; Renin-Angiotensin System; Urea; Urotensins | 2010 |
Mifepristone, a glucocorticoid receptor antagonist, produces clinical and metabolic benefits in patients with Cushing's syndrome.
Topics: Adult; Antihypertensive Agents; Blood Glucose; Blood Pressure; Body Composition; Body Weight; Cushing Syndrome; Diabetes Mellitus, Type 2; Female; Glucose Intolerance; Hormone Antagonists; Humans; Hydrocortisone; Hypertension; Male; Middle Aged; Mifepristone; Quality of Life; Quinolines; Receptors, Glucocorticoid; Urea | 2012 |
Multiple-Dose Pharmacokinetics, Pharmacodynamics, and Safety of the Urotensin-II Receptor Antagonist Palosuran in Healthy Male Subjects.
Topics: Adult; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Male; Middle Aged; Patient Safety; Potassium; Quinolines; Receptors, G-Protein-Coupled; Sodium; Urea | 2018 |
21 other study(ies) available for urea and act 058362
| Article | Year |
|---|---|
Pharmacology of the urotensin-II receptor antagonist palosuran (ACT-058362; 1-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea sulfate salt): first demonstration of a pathophysiological role of the urotensin System.
Topics: Animals; Aorta, Thoracic; Disease Models, Animal; Humans; Ischemia; Kidney Diseases; Male; Quinolines; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Renal Insufficiency; Urea; Urotensins; Vasoconstriction | 2004 |
Effect of lesions of cerebellar fastigial nuclei on lymphocyte functions of rats.
Topics: Animals; Biogenic Monoamines; Brain Chemistry; Brain Diseases; Cell Death; Cell Proliferation; Cerebellar Nuclei; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Flow Cytometry; Glutamic Acid; Hypothalamus; Kainic Acid; Killer Cells, Natural; Lymphocyte Activation; Lymphocytes; Macrolides; Quinolines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Staining and Labeling; Tetrazolium Salts; Thiazoles; Time Factors; Urea | 2005 |
The urotensin-II receptor antagonist palosuran improves pancreatic and renal function in diabetic rats.
Topics: Albuminuria; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Kidney; Male; Pancreas; Quinolines; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Streptozocin; Urea | 2006 |
Urotensin-II and UII-receptor expression and function in the rat adrenal cortex.
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Animals; Cells, Cultured; Male; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Urea; Urotensins | 2006 |
Urotensin II and urotensin II-related peptide (URP) in cardiac ischemia-reperfusion injury.
Topics: Animals; Atrial Natriuretic Factor; Coronary Vessels; Creatine Kinase, MB Form; Humans; Male; Myocardial Contraction; Myocardial Reperfusion Injury; Peptide Hormones; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Reperfusion Injury; Urea; Urotensins; Vasodilation | 2008 |
Evidence for endogenous urotensin-II as an inhibitor of insulin secretion. Study in the perfused rat pancreas.
Topics: Animals; Glucose; Humans; Insulin; Insulin Secretion; Male; Pancreas; Peptide Fragments; Quinolines; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, Somatostatin; Somatostatin; Urea; Urotensins | 2008 |
Urotensin II and urotensin II-related peptide activate somatostatin receptor subtypes 2 and 5.
Topics: Animals; Calcium; Cell Proliferation; CHO Cells; Cricetinae; Cricetulus; Humans; Peptide Hormones; Quinolines; Receptors, Somatostatin; Somatostatin; Swine; Urea; Urotensins | 2008 |
Hemodynamic effects of urotensin II and its specific receptor antagonist palosuran in cirrhotic rats.
Topics: Administration, Oral; Animals; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Hemodynamics; Kidney; Kidney Function Tests; Liver; Liver Cirrhosis, Biliary; Male; Mesenteric Arteries; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Portal Vein; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Messenger; Urea; Urotensins | 2008 |
Palosuran inhibits binding to primate UT receptors in cell membranes but demonstrates differential activity in intact cells and vascular tissues.
Topics: Animals; Cats; Cell Line; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Humans; Inhibitory Concentration 50; Macaca fascicularis; Male; Mice; Quinolines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, G-Protein-Coupled; Species Specificity; Urea; Urotensins | 2008 |
Pro-angiogenic activity of Urotensin-II on different human vascular endothelial cell populations.
Topics: Cell Differentiation; Cell Proliferation; Cells, Cultured; Endothelial Cells; Endothelium, Vascular; Humans; Immunohistochemistry; Neovascularization, Physiologic; Phenotype; Quinolines; Reverse Transcriptase Polymerase Chain Reaction; Urea; Urotensins | 2009 |
Urotensin-II contributes to pulmonary vasoconstriction in a perinatal model of persistent pulmonary hypertension of the newborn secondary to meconium aspiration syndrome.
Topics: Animals; Animals, Newborn; Blood Pressure; Cardiac Output; Disease Models, Animal; Endothelin-1; Female; Humans; Hypertension, Pulmonary; Infant, Newborn; Meconium Aspiration Syndrome; Oxygen; Pulmonary Artery; Quinolines; Receptors, G-Protein-Coupled; Sheep; Time Factors; Up-Regulation; Urea; Urotensins; Vascular Resistance; Vasoconstriction; Vasodilation | 2010 |
Urotensin II receptor and acetylcholine release from mouse cervical spinal cord nerve terminals.
Topics: Acetylcholine; Animals; Cervical Vertebrae; Male; Mice; Motor Neurons; Neuromuscular Junction; Presynaptic Terminals; Quinolines; Receptors, G-Protein-Coupled; Spinal Cord; Urea; Urotensins | 2010 |
Prediction of the three-dimensional structure for the rat urotensin II receptor, and comparison of the antagonist binding sites and binding selectivity between human and rat receptors from atomistic simulations.
Topics: Amides; Amino Acid Sequence; Animals; Binding Sites; Computer Simulation; Humans; Molecular Sequence Data; Protein Binding; Protein Structure, Tertiary; Quinolines; Rats; Receptors, G-Protein-Coupled; Sequence Alignment; Urea | 2010 |
The efficiency of a urotensin II antagonist in an experimental lung fibrosis model.
Topics: Animals; Bleomycin; Endothelin-1; Lung; Male; Pulmonary Fibrosis; Quinolines; Random Allocation; Rats; Rats, Wistar; Transforming Growth Factor beta1; Urea; Urotensins | 2012 |
Prolidase could act as a diagnosis and treatment mediator in lung fibrosis.
Topics: Animals; Biomarkers; Bleomycin; Dipeptidases; Disease Models, Animal; Idiopathic Pulmonary Fibrosis; Lung; Male; Quinolines; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Urea | 2012 |
Effectiveness of palosuran in bleomycin-induced experimental scleroderma.
Topics: Animals; Bleomycin; Endothelin-1; Extracellular Matrix; Fibrosis; Male; Mice; Mice, Inbred BALB C; Quinolines; Scleroderma, Systemic; Skin; Transforming Growth Factor beta1; Urea; Urotensins | 2013 |
Urotensin inhibition with palosuran could be a promising alternative in pulmonary arterial hypertension.
Topics: Animals; Arterial Pressure; Arterioles; Endothelin-1; Familial Primary Pulmonary Hypertension; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Pulmonary Artery; Quinolines; Rats; Rats, Wistar; Transforming Growth Factor beta1; Urea; Urotensins | 2013 |
Palosuran treatment effective as bosentan in the treatment model of pulmonary arterial hypertension.
Topics: Animals; Arterial Pressure; Bosentan; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Hemodynamics; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Pulmonary Artery; Quinolines; Rats; Rats, Wistar; Sulfonamides; Urea; Urotensins | 2014 |
Predicted ligands for the human urotensin-II G protein-coupled receptor with some experimental validation.
Topics: Animals; Binding Sites; Databases, Protein; Humans; Ligands; Mice; Molecular Docking Simulation; Monte Carlo Method; Protein Binding; Protein Structure, Tertiary; Quinolines; Receptors, G-Protein-Coupled; Urea | 2014 |
Urotensin receptors as a new target for CLP induced septic lung injury in mice.
Topics: Acute Lung Injury; Animals; Cecum; Cytokines; Gene Expression; Glutathione; Ligation; Lung; Male; Malondialdehyde; Mice, Inbred BALB C; NF-kappa B; Peptide Fragments; Quinolines; Receptors, G-Protein-Coupled; Sepsis; Superoxide Dismutase; Urea; Urotensins | 2019 |
Urotensin receptor antagonist palosuran attenuates cyclosporine-a-induced nephrotoxicity in rats.
Topics: Animals; Creatinine; Cyclosporine; Immunosuppressive Agents; Kidney; Kidney Diseases; Male; Models, Animal; Quinolines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Urea; Urotensins | 2019 |