uracil and fluorouracil
uracil has been researched along with fluorouracil in 993 studies
Research
Studies (993)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 367 (36.96) | 18.7374 |
| 1990's | 198 (19.94) | 18.2507 |
| 2000's | 306 (30.82) | 29.6817 |
| 2010's | 97 (9.77) | 24.3611 |
| 2020's | 25 (2.52) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Hall, IH; Lee, KH; Wu, YS | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Aryasomayajula, R; Bandi, PR; Jennepalli, S; Kura, RR; Musku, MR; Rondla, SR; Vedula, MS | 1 |
| Davies, J; Schindler, D | 1 |
| Sviridenko, OP | 1 |
| Forsthoefel, PF; Williams, ML | 1 |
| Johnson, GA | 1 |
| Simpson, LD; Zimbrick, JD | 1 |
| Beck, CF; Howlett, GJ | 1 |
| Chao, LY; Saunders, PP | 1 |
| Fast, R | 1 |
| Fujii, S; Ikenaka, K; Kitano, S; Shirasaka, T | 2 |
| Reinhard, P; Schluchter, M | 1 |
| Fujii, S; Fukushima, M; Ikenaka, K; Shirasaka, T | 1 |
| Crittenden, GC; Haugen, O; Prydz, S | 1 |
| Guganig, ME; Reyes, P | 1 |
| Swenton, JS; Wexler, A | 1 |
| Abe, R; Arima, S; Fukuyama, N; Hisatsugu, T; Kuroda, Y; Nakamura, Y; Ohkuma, R; Ohsato, K; Yamamoto, H; Yamanouchi, A | 1 |
| Inaba, S; Kawai, K; Kondo, Y; Ogino, A; Tsuchiya, K; Ueda, Y; Umeda, T | 1 |
| Hosoda, Y; Miyakawa, T; Okamura, H; Okubo, S; Oshima, Y; Shiina, E; Shimizu, M; Suda, Y; Tokura, Y; Uchida, K | 1 |
| Baba, E; Fukushima, T; Kataoka, A; Kondo, Y; Masuko, H; Ohmori, K; Ohsawa, S; Sawaguchi, Y; Shiroto, H; Takahashi, T | 1 |
| Kusumoto, T; Miyagi, M; Nakashima, T | 1 |
| Akagi, M; Kakegawa, T; Maehara, Y; Shimazu, H; Sugimachi, K; Tomita, M | 1 |
| Demard, F; Etienne, MC; Fleming, RA; Milano, G; Renée, N; Schneider, M; Thyss, A | 1 |
| Chikazawa, K; Kito, H; Nagase, H; Ose, Y; Sato, T; Yamamori, H | 1 |
| Akino, H; Isomatu, Y; Kanimoto, Y; Miwa, Y; Okada, K; Suzuki, Y | 1 |
| De Clercq, E; Marquez, VE; Murase, J | 1 |
| Fujita, K; Munakata, A | 1 |
| Daher, GC; Diasio, RB; el Kouni, MH; Naguib, FN; Soong, SJ; Zhang, RW | 1 |
| Adachi, S; Akaza, H; Ishitsuka, H; Kanazawa, K; Miwa, M; Nitta, K; Sekiguchi, F; Tokita, H | 1 |
| Hayashi, H; Hazama, S; Murakami, T; Oka, M; Suzuki, T | 1 |
| Ban, Y; Ito, Y; Kawada, Y; Kuriyama, M; Maeda, S; Shinoda, I; Tada, K; Takahashi, Y; Takeuchi, T; Yamamoto, N | 1 |
| Fukumoto, M; Imai, S; Kawabata, K; Morimoto, H; Nio, Y; Shiraishi, T; Tobe, T; Tseng, CC; Tsubono, M | 1 |
| Chen, JT; Fujimoto, I; Hamada, T; Hasumi, K; Hirai, Y; Nakayama, K; Shimizu, Y; Teshima, H; Yamauchi, K; Yokosuka, K | 1 |
| Horiuchi, M; Kaneko, S; Komiyama, S; Miyake, H; Ogasawara, H; Sugita, M; Tsukuda, M | 1 |
| Amemiya, A; Emoto, T; Fujii, M; Han, N; Itou, A; Iwasaki, T; Tsujimura, T; Yoshikawa, K | 1 |
| Arai, K; Awane, Y; Kitamura, M; Miyashita, K | 1 |
| Fujita, M; Fujita, Y; Ota, J; Sakamoto, Y; Sugimoto, T; Taguchi, T | 1 |
| Houjo, K; Kawano, N; Moriya, Y; Sugihara, K | 1 |
| Hara, I; Kameyama, Y; Sakaki, Y; Tateishi, A; Yamada, N | 1 |
| Fukatsu, H; Hirata, N; Honda, N; Muramatsu, T; Segawa, A; Senda, H; Yamada, Y | 1 |
| Imai, S; Morimoto, H; Nio, Y; Shiraishi, T; Tobe, T; Tseng, CC; Tsubono, M | 1 |
| Holbrook, CT; Klann, RC; Nyce, J | 1 |
| de Montigny, J; Jund, R; Kern, L; Lacroute, F | 1 |
| Fujioka, T; Hasegawa, M; Ishikura, K; Koike, H; Kubo, T; Nomura, K; Okamoto, T; Tanji, S | 1 |
| Hisamatsu, K; Ihara, T; Kirimoto, K; Matsuda, M; Nanba, K; Okamoto, E; Suemitsu, H; Yamada, M | 1 |
| Irie, G; Kamada, T; Matsuoka, Y; Shirato, H; Takamura, A; Tsuji, H; Tsujii, H | 1 |
| Asada, I; Furutani, M; Harada, T; Hayashi, S; Kitao, T; Matsushita, T; Shirosaki, H; Tanaka, T | 1 |
| Hieda, S; Ishihara, M; Noguchi, M; Sawaguchi, K; Ueno, N; Yabushita, H | 1 |
| Anai, H; Kido, Y; Korenaga, D; Kusumoto, H; Kusumoto, T; Maehara, Y; Okamura, T; Sakaguchi, Y; Sugimachi, K | 1 |
| Inoue, K; Mitani, K; Morishita, Y; Yamashita, K | 1 |
| Hosoi, H; Kitagawa, M; Sinmyo, K; Susaki, H; Suwa, H; Yamaguchi, K | 1 |
| Fujii, S; Fukushima, M; Shimamoto, Y; Shirasaka, T | 1 |
| Imai, S; Nio, Y; Ohgaki, K; Shiraishi, T; Tobe, T | 1 |
| Furusawa, M; Hara, Y; Kono, A | 1 |
| Iwano, I; Kikuchi, Y; Kita, T; Kizawa, I; Kuki, E; Miyauchi, M; Oomori, K | 1 |
| Ono, T; Sawaki, S; Sudo, K; Tsukuda, M; Yanoma, S | 1 |
| Aoki, H; Ishibashi, M; Itoh, S; Kadowaki, A; Kogure, H; Tagaya, N; Tajima, T; Tajima, Y; Tomita, T | 1 |
| Ando, J; Kosaka, A; Sumiyoshi, K | 1 |
| Nishida, M; Sekiguchi, I; Suzuki, M; Tamada, T | 3 |
| Ito, Y; Matsuoka, S; Misawa, K; Nagafuchi, E; Nakajima, Y; Ogasawara, K; Sato, N; Uchino, J; Une, Y | 1 |
| Fujii, M; Hosoda, H; Inuyama, Y; Kohno, N; Takaoka, T; Tanaka, J | 1 |
| Ghose, AK; Ghose, R; Singh, RK; Singh, SM; Singh, UP; Sodhi, A | 1 |
| Martin, DS; Sawyer, RC; Stolfi, RL | 1 |
| Chu, WC; Horowitz, J | 1 |
| Atassi, G; Bibby, MC; Double, JA; Dumont, P; McCormick, JE; McElhinney, RS; Pratesi, G; Radacic, M | 1 |
| Suenaga, M | 1 |
| Ito, T; Izumi, T; Kurihara, M; Sasaki, J | 1 |
| Goto, S; Horiuchi, Y; Nagayo, T; Ohkita, T; Shimaji, T; Suga, S; Yokoyama, Y | 1 |
| Kato, T; Ota, K | 1 |
| Fujii, S | 1 |
| Eda, H; Fujimoto, K; Fukuda, H; Ishitsuka, H; Miwa, M | 1 |
| Lin, FH; Williams, WM | 1 |
| Laurensse, EJ; Peters, GJ; Pinedo, HM | 1 |
| Kiang, DT; Mirkin, BL; O'Dea, RF; Ramnaraine, ML; Stoeckeler, JS; Tuchman, M | 1 |
| Oguma, S; Ouchi, K; Owada, Y; Sakai, K; Sato, R; Sato, T | 1 |
| Inoue, S; Kato, H; Okada, Y; Takahashi, K; Yamanaka, A | 1 |
| Fujiwara, K; Inoue, K; Kaneshige, E; Kobashi, Y; Kono, I; Sekiba, K; Tanimura, T | 1 |
| Oiwa, T; Saito, H | 1 |
| Kimura, M; Koida, T; Sugihara, S | 1 |
| Hayakawa, M; Morise, K; Ohno, R; Saito, H | 1 |
| Arima, S; Futami, K; Kinashi, M; Shigeta, M; Shimura, H | 1 |
| Kamiya, H; Nagai, S; Sakai, K; Sato, K | 1 |
| Aota, M; Daitoh, N; Jinno, K; Nakayama, S; Yokomise, H | 1 |
| Anai, H; Kusumoto, H; Maehara, Y; Masuda, H; Sugimachi, K | 1 |
| Kimura, K; Seki, H; Takahashi, H | 1 |
| Asagoe, T; Hanaue, H; Kitano, Y; Kurosawa, T; Miyakawa, S; Nemoto, A; Shikata, J; Takada, T; Yamamoto, H; Yasuda, H | 1 |
| Konami, T; Konishi, T; Pak, K; Takayama, H; Tomoyoshi, T | 1 |
| Amano, T; Fujimoto, Y; Imada, T; Matsumoto, A; Noguchi, Y; Tamura, S; Yamamoto, Y | 1 |
| Abe, T; Horiike, S; Inazawa, J; Misawa, S; Nishigaki, H; Okuda, T; Taniwaki, M; Tsuji, H; Yashige, H; Yokota, S | 1 |
| Kamiwatari, M; Kosya, S; Nagata, Y; Shiokawa, H; Ueda, T; Yamada, E; Yamamoto, S | 1 |
| Fujii, S; Fukushima, M; Shirasaka, T; Tatsumi, K | 1 |
| Aoki, Y; Fukunaga, H; Katsumi, M; Kawaguchi, T; Konishi, R; Oka, S; Takifuji, K; Tamaki, Y; Yukawa, H | 1 |
| Honda, M; Hosoya, Y; Mukae, K; Murahashi, I; Takasaki, E | 1 |
| Adachi, S; Ishida, M; Kanazawa, K; Misawa, Y; Takeuchi, S; Yoshiya, N; Yuzawa, H | 1 |
| Ishizawa, T; Shimazu, H; Takao, S; Yamada, K | 1 |
| Fujita, Y; Nishioka, B; Otsuji, E; Takahashi, T; Yamaguchi, T; Yamane, T | 1 |
| Fujimoto, T; Ishida, T; Kurogoh, F; Ohyanagi, H; Okumura, S; Saitoh, Y; Shimada, Y; Tagashira, Y; Uchida, K; Yamamoto, M | 1 |
| Anai, H; Kusumoto, H; Kusumoto, T; Maehara, Y; Sugimachi, K | 2 |
| Hamada, J; Hosokawa, M; Kobayashi, H; Komatsumoto, M; Li, S; Okayasu, T; Takeichi, N; Tanabe, T | 1 |
| Abe, M; Amano, T; Imada, T; Matsumoto, A; Tamura, S; Yamamoto, Y | 1 |
| Baba, T; Furukohori, N; Itoh, T; Kawata, K; Kimura, T; Munakata, A; Saitoh, S; Sakata, Y; Suzuki, H; Tamura, Y | 1 |
| Inoue, H; Kawada, S; Koide, S; Ogawa, J; Shohtsu, A | 1 |
| Kikuchi, K; Kunii, Y; Mori, Y; Nitta, A; Saitou, T; Takahashi, N | 1 |
| Fukushi, G; Itoh, T; Kimura, M; Kimura, T; Kishibe, T; Saitoh, S; Sakata, Y; Suzuki, H; Tamura, Y; Tsushima, K | 1 |
| Hashimoto, T; Iigima, N; Iwasaki, M; Kameya, S; Narita, M; Sato, M; Sou, M; Takeshita, T | 1 |
| Eida, K; Fukuda, Y; Hirano, T; Ishii, T; Kotake, Y; Kusano, H; Nakagoe, T; Shimizu, T; Shimoyama, T; Tomita, M | 1 |
| Hatano, T; Hayakawa, M; Igarashi, M; Kashiwabara, N; Koyama, Y; Miyazato, T; Osawa, A; Saito, S; Sato, K | 1 |
| Hagenhoff, B; Severin, E | 1 |
| Bronk, JR; Lister, N; Lynch, S | 1 |
| Kraal, I; Leyva, A; Peters, GJ; Pinedo, HM; van Groeningen, CJ | 1 |
| Gerok, W; Holstege, A; Pausch, J | 1 |
| O'Dea, RF; Ramnaraine, ML; Tuchman, M | 2 |
| Arai, Y; Endo, T; Kido, C; Ota, K; Suyama, K | 1 |
| Iizuka, N; Machida, T; Masuda, F; Mori, Y; Nakada, J; Ohnishi, T; Suzuki, M | 1 |
| Kamiya, H; Nagai, S; Sakai, K; Sawada, T; Tsukasaki, K | 1 |
| Kimura, M; Koida, T | 1 |
| Segawa, T; Toide, K; Unemi, N | 1 |
| Cha, S; el Kouni, MH; Naguib, FN | 1 |
| Hirano, H; Kawai, Y; Nishiyama, M; Sugiyama, Y; Taniguchi, H; Uematsu, A; Yanase, H | 1 |
| Ohwada, M; Sekiguchi, I; Suzuki, M; Tamada, T | 1 |
| Ikeya, T; Ishikawa, H; Izuo, M; Kaneko, H; Miyamoto, Y; Seki, M; Takeshita, M; Tozuka, S; Usui, R | 1 |
| Fujii, M; Hosoda, H; Inuyama, Y; Saito, S; Takaoka, T; Tanaka, J | 1 |
| Balzarini, J; Bricaud, H; De Clercq, E; Desgranges, C; Drouillet, F; Herdewijn, P; Razaka, G | 1 |
| Cano, JP; Cross, DS; Diasio, RB; Gewirtz, DA; Goldman, ID; Sommadossi, JP | 1 |
| Darnowski, JW; Handschumacher, RE | 1 |
| de Jong, AP; Kok, RM; Lankelma, J; Peters, GJ; van Groeningen, CJ | 1 |
| Cihák, A; Veselỳ, J | 1 |
| Ryan, AM | 1 |
| Leĭkina, FI; Smolianskaia, AZ | 1 |
| Drouhet, E; Mercier-Soucy, L; Montplaisir, S | 1 |
| Killion, K; Rao, KV; Tanrikut, Y | 1 |
| Hahn, GA; Mandel, HG | 1 |
| Kummer, D | 1 |
| Beck, CF; Ingraham, JL; Neuhard, J; Thomassen, E | 1 |
| Hanna, C | 1 |
| Beck, A; Tan, YL | 1 |
| Marzluf, GA | 1 |
| Gauri, KK; Kohlhage, H | 1 |
| Guganig, M; Reyes, P | 1 |
| Neta, P | 1 |
| Schweiger, K; Streffer, C | 1 |
| Pitot, HC; Wilkinson, DS | 1 |
| Bolund, C | 1 |
| Kelln, RA; Warren, RA | 1 |
| Bullock, J; Khalil, FL; Lea, MA; Morris, HP | 1 |
| Agarwal, DP; Eickhoff, K; Goedde, HW | 1 |
| Geller, M; Kulakowska, I; Lesyng, B; Wierzchowski, KL | 1 |
| Jund, R; Lacroute, F | 2 |
| Garrett, ER; Nolte, H | 1 |
| Bolund, C; Sköld, O | 1 |
| Mironov, AS; Sukhodolets, VV | 1 |
| Brozmanová, J; Sedliaková, M | 1 |
| Doolittle, CH; Hahn, GA; Mandel, HG | 1 |
| Belousova, AK; Meĭren, DV | 1 |
| Chan, A; Ewart, DF; Walker, IG | 1 |
| Lohmann, W; Penka, V | 1 |
| Painter, RB; Young, BR | 1 |
| Bärwolff, D; Langen, P; Matthes, E | 1 |
| Geissler, E; Isserstedt, K | 1 |
| Baliga, BS; Hendler, S; Srinivasan, PR | 1 |
| Kaiser, II | 2 |
| Heidelberger, C | 1 |
| Brozmanová, J; Sedliaková, M; Slezáriková, V; Stefunková, E | 1 |
| Mueller, M; Russo, V; Selzer, G; Stahl, FW; Yegian, CD | 1 |
| Mandel, HG; Reich, M | 2 |
| Hoshi, A; Kanzawa, F; Kumagai, K; Kuretani, K | 1 |
| Goz, B; Prusoff, WH | 1 |
| Iushkov, SF; Korol'chuk, VP | 1 |
| Barton, DH; Hesse, RH; Pechet, MM; To, HT | 1 |
| Deyrup, CL; Sander, EG | 1 |
| Antonovskiĭ, VL; Gukovskaia, AS; Prokop'eva, TM; Sukhoroukov, BI | 1 |
| Bansal, KM; Patterson, LK; Schuler, RH | 1 |
| Bansal, KM; Patterson, LK | 1 |
| Cooper, GM; Dunning, WF; Greer, S | 1 |
| Blitzer, BL; Cushley, RJ; Lipsky, SR | 1 |
| Baranosky, J; Lebowitz, E; Richards, P | 1 |
| Dorsett, MT; Gentry, GA; Morse, PA | 1 |
| Abramson, IJ; Smibert, RM | 1 |
| Cernohorský, IJ; Miller, V; Pacáková, V | 1 |
| Barner, HD; Cohen, SS; Stern, JL | 1 |
| Hills, DC; Horowitz, J | 1 |
| Horiuchi, T; Ohshima, Y | 1 |
| Edlin, G; Neuhard, J | 1 |
| Kosarev, VA; Nikiforov, AM | 1 |
| Ebner, H | 1 |
| Hall, TC; Kessel, D; Reyes, P | 1 |
| Reynolds, VH; Van Way, CW | 1 |
| Soska, J; Sosková, L; Svoboda, A | 1 |
| Giege, R; Weil, JH | 1 |
| Oriuchi, T | 1 |
| Kowollik, G; Langen, P | 1 |
| de Kloet, SR | 1 |
| Yoshihara, H | 1 |
| Ebel, JP; Giege, R; Heinrich, J; Weil, JH | 1 |
| Galun, E; Torrey, JG | 1 |
| Burk, D; Woods, MW | 1 |
| Belkhode, ML; Gotto, AM; Touster, O | 1 |
| Jordan, RL; Schumacher, H; Wilson, JG | 1 |
| Jordan, RL; Schumacher, HJ; Wilson, JG | 1 |
| Kamen, MD; Yamashita, J | 1 |
| Gauri, KK; Malorny, G; Schiff, W | 1 |
| Graham, AF; Kirk, C | 1 |
| Nathans, D; Shimura, Y | 1 |
| Lallier, R | 1 |
| Goldberg, AR; Machledt, JH; Pardee, AB | 1 |
| Thiry, L | 1 |
| Galun, E; Gressel, J | 1 |
| Green, WR; Lis, AW | 1 |
| Westwood, JC | 1 |
| Kumkumadzhian, VA; Papoian, SA | 1 |
| Dubash, PJ; Rege, DV | 1 |
| Bunker, JE; Keller, F; Tyrrill, AR | 1 |
| Baker, BR; Kawazu, M; McClure, JD | 1 |
| Gropper, L; Shimkin, MB | 1 |
| Kallio, T; Kukko, E | 1 |
| Goulian, M; Ingraham, HA; Tseng, BY | 2 |
| Kukko, E; Saarento, H | 1 |
| Rockstroh, PA; Warner, HR | 1 |
| Fujioka, Y; Harada, K; Kiya, K; Kodama, Y; Okamoto, H; Uozumi, T | 1 |
| Fujii, M; Hosoda, H; Inuyama, Y; Kohno, N; Takaoka, T; Tnaka, J | 1 |
| Buxton, FP; Radford, A | 1 |
| Aubert, C; Cano, JP; Coassolo, P; Rigault, JP; Sommadossi, JP | 1 |
| Kimura, K; Suga, S | 1 |
| Fujii, S; Shirasaka, T | 2 |
| Hüttermann, J | 1 |
| Matsumoto, S; Nogaki, H; Tamaki, N; Taomoto, K | 1 |
| Ishii, K; Kagaya, T; Koike, D; Odake, Y; Ohyama, K; Saitoh, T; Takebe, T; Takiyama, Y | 1 |
| Enomoto, S; Kusama, M; Nagura, H; Ono, T; Utsunomiya, Y | 1 |
| Bekki, E; Hashimoto, I; Kasai, Y; Mikami, J; Nakamura, T; Nakanishi, Y; Nishi, H; Nishindai, H; Sawada, Y; Yoshimoto, M | 1 |
| Fujii, S; Hoshino, A; Kamiya, O; Kimura, K; Kojima, T; Nagata, K; Ohara, K; Sugihara, T; Suzuki, M; Yamada, M | 1 |
| Akiyama, J; Sagara, Y; Takeda, Y | 1 |
| Haruno, A; Kunimune, Y; Morita, K; Unemi, N; Yamamoto, J; Yamashita, K; Yoshimura, Y | 1 |
| Fujii, S; Harada, N; Miyauchi, S; Nakamura, H; Nishioka, N; Shirasaka, T; Tanaka, H; Yu-Qin, W | 1 |
| Izumi, T; Kurihara, M; Maruyama, T; Sasaki, Y; Shirakabe, H | 1 |
| Fujita, F; Fujita, M; Taguchi, T | 1 |
| Byfield, JE; Hornbeck, CL; Tang, SG | 1 |
| Fujita, H | 1 |
| Hatae, M; Hokanishi, H; Terahara, M | 1 |
| Biriukova, IV; Zinchenko, VV | 1 |
| Gall, H; Kraal, I; Lankelma, J; Leyva, A; Peters, GJ; Pinedo, HM; van Groeningen, CJ | 1 |
| Kraal, I; Laurensse, E; Leyva, A; Peters, GJ; Pinedo, HM | 1 |
| Fujii, S; Fukushima, M; Ikenaka, K; Kitano, S; Maehara, Y; Nakamura, H; Shirasaka, T | 1 |
| Isobe, K; Kimura, K; Kitamura, M; Kubo, K; Shimaji, T; Suga, S; Suzuoki, Y | 1 |
| Fujii, S; Marunaka, T; Minami, Y; Nagamachi, M; Umeno, Y; Yoshida, K | 1 |
| Marunaka, T; Umeno, Y | 1 |
| Sakurai, Y | 1 |
| Kawaguchi, Y; Masuda, H; Nagayama, S; Yasuda, A | 1 |
| Haruno, A; Toide, K; Unemi, N; Yamamoto, J; Yoshimura, Y | 1 |
| Wild, DG; Wilson, GI | 1 |
| Kanbara, H; Kawashima, Y; Kitade, F; Kurokawa, A; Okada, K; Okajima, K; Sakuramoto, K; Yamada, S | 1 |
| Tschiersch, B | 1 |
| Funatsuka, A; Kubo, K; Tamaki, N | 1 |
| Komi, N; Korematsu, H; Kunitomo, K; Kuwashima, T; Tamura, T; Toyosaki, M; Yoshikawa, H | 1 |
| Hirota, T; Okazaki, N; Tajiri, H; Yamaguchi, H; Yoshida, S; Yoshimori, M | 1 |
| Asahi, T; Kaneshige, T; Kumon, H; Matsumura, Y; Ohmori, H; Ozaki, Y; Tsushima, T; Yoshimoto, J | 1 |
| Higashi, Y; Nomoto, C; Suemasu, K | 1 |
| Furue, H | 1 |
| Santi, DV | 1 |
| Wasternack, C | 1 |
| Kelln, RA; Zak, VL | 1 |
| Hiroto, I; Komiyama, S; Makishima, K; Matsumura, Y; Nakashima, T; Nomura, Y | 1 |
| McIvor, RS; Plagemann, PG; Wohlhueter, RM | 1 |
| Okabe, H; Takeda, S; Toko, T; Unemi, N; Yuasa, C | 1 |
| Demachi, H; Konishi, K; Kuroda, Y; Tsugawa, K; Tsuji, M; Yabushita, K | 1 |
| Allegra, CJ; Grogan, L; Sotos, GA | 1 |
| Henson, E; McClarty, G; Wang, LL | 1 |
| Hirata, K | 1 |
| Fujii, K; Hanaue, H; Kurosawa, T; Mitomi, T; Nakasaki, H; Tajima, T; Yasuda, S | 1 |
| Bahn, E; Davidson, J; DeMoll, E; Gojkovic, Z; Hjulsager, C; Piskur, J; Rawls, J; Stokbro, B; Søndergaard, L | 1 |
| Furukawa, H; Goto, S; Hiratsuka, M; Iwanaga, T; Kito, T; Nakajima, T; Nakazato, H; Ohta, K; Okabayashi, K; Yamamura, Y | 1 |
| Suda, Y; Uchida, K | 1 |
| Abdulmalek, S; McCarthy, CM; Montoya, DP | 1 |
| Hiroshige, K; Ikeda, T; Korenaga, D; Nishizaki, T; Sugimachi, K; Takenaka, K; Yoshida, K | 1 |
| Harada, S; Matsuo, M; Miyata, M; Obara, T; Oikawa, H; Ping, L; Takahashi, T; Yanagisawa, T | 1 |
| Ikeda, K; Shibata, N; Tamai, M | 1 |
| Arima, H; Arita, S; Hachisu, T; Hisikawa, E; Kashiwabara, H; Matsumoto, M; Sakamoto, K; Yaguchi, H; Yokoyama, T | 1 |
| Aida, I; Kasuga, Y; Ohwada, M; Sato, I; Suzuki, M; Tamura, T | 1 |
| Horiuchi, Y; Ina, K; Iwase, H; Kaneko, H; Kuroiwa, A; Kusugami, K; Morise, K; Oka, Y; Shinoda, M; Suga, S | 1 |
| Ban, K; Higashi, H; Ishihara, S; Kitazaki, M; Machida, T; Masuda, K; Matsumoto, M; Noma, M; Ota, M; Shida, H | 1 |
| el Kouni, MH; Hao, SN; Naguib, FN | 1 |
| Higaki, T; Ito, Y; Kono, S; Moriguchi, M; Nakata, Y; Oishi, H; Seki, N; Takahashi, T; Takano, S; Watanabe, Y | 1 |
| Wakui, A | 1 |
| Hammer, K; Martinussen, J | 1 |
| Kitada, K; Mochida, A; Nakamura, H; Omori, S | 1 |
| Kanetake, H; Minami, Y; Saito, Y; Sakai, H | 1 |
| Kanazawa, Y; Kurogi, S; Masuda, K; Noda, Y; Shinohara, S | 1 |
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| Aoki, T; Ashikaga, K; Hirai, K; Kawahara, H; Kimura, C; Kuroda, H; Ono, M; Sato, K; Yamada, Y | 1 |
| Hidaki, T; Kato, T; Sugimori, H; Tazaki, T; Tsukamoto, N; Yakushiji, M; Yamabe, T | 1 |
| Baccanari, DP; Davis, ST; Joyner, SS; Spector, T | 1 |
| Hayashi, K; Imaoka, T; Kawaguchi, T; Kubo, M; Matsui, Y; Miyauchi, S; Utsunomiya, T | 1 |
| Fernandez-Salguero, P; Furuya, H; Gonzalez, FJ; Lin, K; McBride, OW; Podschun, B; Schnackerz, KD; Yokota, H | 1 |
| Hashimoto, T; Hirano, K; Kanehira, E; Kawakami, K; Omura, K; Shirasaka, T; Watanabe, S; Watanabe, T; Watanabe, Y | 1 |
| Kühnel, A; Podschun, B; Stopper, H | 1 |
| Fukushima, S; Hamada, A; Kawaguchi, T; Morinaga, A; Nakano, M; Saneyoshi, M | 1 |
| Cao, S; Rustum, YM; Spector, T | 1 |
| Baba, H; Inutsuka, S; Kohnoe, S; Maehara, Y; Oshiro, T; Sugimachi, K; Takahashi, I; Takeuchi, H | 1 |
| Imaoka, T; Kawaguchi, T; Kishi, K; Kiyono, K; Kubo, M; Tatsumi, K; Yamauchi, T; Yanagihara, Y | 1 |
| Homma, A; Iizuka, K; Nakamaru, Y; Yonekawa, H | 1 |
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| Sirover, MA; Tallarida, RJ; Wurzer, JC | 1 |
| Hanai, J; Honjoh, M; Ishikawa, Y; Ohnishi, N; Sakaguchi, H; Takeyama, M | 1 |
| Baccanari, DP; Davis, ST; Knick, VC; Spector, T | 1 |
| Kimura, K; Ko, Y; Kumada, K; Makuuchi, M; Midorikawa, T; Nakano, H; Namatame, K; Sasaki, E; Shimada, K; Takahashi, H | 1 |
| Azuma, A; Hanaoka, K; Kobayashi, T; Matsuda, A; Minakawa, N; Nakajima, Y; Nishizono, N; Sasaki, T; Suzuki, M; Tanaka, M | 1 |
| Kasahara, N; Kudo, H; Mizuno, M; Mori, T; Nagasawa, H; Sakamoto, S; Sugiura, Y; Suzuki, S | 1 |
| Kumagai, K; Masuo, K; Nishida, Y; Yasui, A; Yoshitoshi, A | 1 |
| Hashimoto, T; Ishida, F; Omura, K; Watanabe, Y | 1 |
| Baba, S; Itaya, S; Kobayashi, T; Matsuda, T; Motai, H; Shimada, J; Suzuki, K; Tsuge, I | 1 |
| Hirata, K; Sasaki, K; Shirasaka, T; Yamamitsu, S | 1 |
| Domin, BA; Mahony, WB; Zimmerman, TP | 1 |
| Kosaki, G; Kurihara, M; Tominaga, T; Yoshida, Y | 1 |
| Furusawa, M; Kakeji, Y; Matsukuma, A; Matsuoka, H; Morita, M; Ohno, S; Seo, Y; Tomoda, H | 1 |
| Itsubo, M | 1 |
| Hishinuma, S; Ikeda, T; Inada, T; Kotake, K; Koyama, Y; Kubota, T; Ogata, Y; Ozawa, I; Shimizu, H | 1 |
| Higashigawa, M; Inagaki, S; Kagawa, Y; Kakito, H; Ohkubo, T; Ooi, K; Sakurai, M; Sumida, K | 1 |
| Ishikawa, H; Kusano, H; Miyashita, K; Nakazaki, T; Ogawa, T; Shimizu, T; Shimoyama, T; Yasutake, T; Yoshida, A; Yoshida, K | 1 |
| Azuma, S; Furuta, T; Kato, M; Kuno, T; Nishina, T; Saji, S; Takahashi, K; Tanemura, H | 1 |
| Fujimoto, S; Kaneko, M; Kikugawa, M; Kontani, Y; Tamaki, N | 1 |
| Fujita, F; Fujita, M; Inaba, H; Taguchi, T | 1 |
| Harada, M; Kimura, A; Koga, K; Miura, I; Nishitani, H | 1 |
| Sakakibara, N; Watanabe, H | 1 |
| Iida, A; Ikeda, N; Komatsu, T; Ookubo, K | 1 |
| Bargnoux, PJ; Demard, F; Fleming, RA; Gaspard, MH; Milano, GA; Plagne, R; Renée, N; Schneider, M; Thyss, A | 1 |
| Baccanari, DP; Cao, S; Davis, ST; Joyner, SS; Rustum, YM; Spector, T | 1 |
| Asano, K; Imai, R; Somekawa, Y; Taira, A | 1 |
| Honma, A; Ishikawa, N; Ishikawa, T; Kamimura, T; Oota, H; Ozaki, T; Takeda, K; Yoshida, T | 1 |
| Inutsuka, K; Maruiwa, M; Noutomi, M; Ohta, J; Tokuhara, K | 1 |
| Dohi, K; Goto, T; Haruta, R; Kataoka, T | 1 |
| Fukushima, S; Hamada, A; Kawaguchi, T; Nakano, M; Saneyoshi, M; Shimizu, S | 1 |
| Drengler, R; Eckardt, J; Eckhardt, G; Villalona-Calero, M; Von Hoff, D | 1 |
| Araki, H; Hiramatsu, Y; Kamiyama, Y; Kojima, Y; Nakagawa, A; Nakagawa, M; Ogura, T; Shirasaka, T | 1 |
| Handa, H; Honjo, K; Kawanishi, J; Nakamura, T; Nakayama, N; Ohi, M; Tsuji, Y; Uehara, S; Watanabe, Y; Yoshihito, H | 1 |
| Fujii, M | 2 |
| DeGoeij, K; Mester, J; Sluyser, M | 1 |
| Miura, K; Murayama, H; Sakamoto, J | 1 |
| Rowinsky, EK | 1 |
| Fujii, M; Imanishi, Y; Kanke, M; Ohno, Y; Tokumaru, Y | 1 |
| Kobayashi, K | 1 |
| Adjei, AA; Baker, SD; Donehower, RC; Doucette, M; Grochow, LB; Hohneker, JA; Khor, SP; Noe, DA; Rowinsky, EK; Sartorius, SE; Spector, T | 1 |
| De Guzman, LM; Fernando, GY; Guancia, AA; Romana, IB; Samson, MC; Villalon, AH | 1 |
| Rustum, YM | 1 |
| Taguchi, T | 4 |
| Amyx, H; Baccanari, DP; Davis, ST; Khor, SP; Nelson, D; Spector, T | 1 |
| Asano, M; Mori, T; Takahashi, K; Yasuno, M | 1 |
| Kouchi, Y; Maeda, Y; Morinaga, H; Ohuchida, A | 1 |
| Iwama, T; Kawachi, Y; Kudo, H; Murakami, S; Okayasu, I; Sagara, T; Sakamoto, S; Tsukada, K | 1 |
| Etienne, MC; Fischel, JL; Formento, P; Milano, G; Renée, N; Spector, T | 2 |
| Inaji, H; Koyama, H; Motomura, K; Noguchi, S | 1 |
| Hata, K; Kaganoi, J; Nanbu, H; Nishitai, R; Ohsumi, K; Tokunaga, Y | 1 |
| Allain, P; Boisdron-Celle, M; Gamelin, E; Larra, F; Robert, J; Turcant, A | 1 |
| Baba, H; Kakeji, Y; Maehara, Y; Ohno, S; Sugimachi, K | 1 |
| Pazdur, R | 1 |
| Jones, J; Mamounas, EP; Wickerham, DL; Wieand, HS; Wolmark, N | 1 |
| Skillings, JR | 1 |
| Carmichael, J | 1 |
| Diaz-Canton, E; Pazdur, R | 1 |
| Minsky, BD | 1 |
| Codes, M; Dugue, A; Garcia, E; Iglesias, L; Moreno, JA; Murillo, E; Torrija, E; Virizuela, JA | 1 |
| Diaz-Rubio, E; Garcia Carbonero, I; González-Larriba, JL; Perez Segura, P; Sastre Valera, J | 1 |
| Arikian, S; de Andrade, CA; Delfino, C; Doyle, J; Murad, A; Sinha, N | 1 |
| Arellano, M; Malet-Martino, M; Martino, R; Spector, T | 1 |
| Adams, ER; Bergman, AM; Holland, SK; Pizzorno, G; Zhao, Y | 1 |
| Gu, X; Huang, L; Pookanjanatavip, M; Santi, DV | 1 |
| Watanabe, T | 2 |
| Calabresi, P; Chen, TM; Chu, E; Chu, MY; Chu, SH; Lipsky, MH; Pan, BC; Yee, LK | 1 |
| Burris, HA; Diasio, R; Hohneker, J; Janisch, L; Khor, SP; Lucas, VS; Ratain, MJ; Schilsky, RL; Smetzer, L; Von Hoff, DD | 1 |
| Diasio, RB | 6 |
| Duley, JA; Nethersell, AB | 1 |
| Peters, GJ; Pinedo, HM; van Groeningen, CJ | 1 |
| Ando, E; Fukuda, H; Fukumori, K; Kato, O; Kusaba, T; Sata, M; Tanaka, M; Tanikawa, K; Yamamoto, H; Yamashita, F; Yano, Y | 1 |
| Akamo, Y; Fukui, T; Kidouchi, K; Kobayashi, K; Manabe, T; Mizuno, I; Mohri, N; Sumi, S; Takeyama, H | 1 |
| Punt, CJ | 1 |
| Hamajima, N; Imaeda, M; Kidouchi, K; Kodama, K; Ohba, S; Sumi, S; Togari, H; Wada, Y | 1 |
| Elizondo, G; Fernandez-Salguero, P; Gonzalez, FJ; McLeod, HL; Raunio, H; Sapone, A; Wei, X | 1 |
| Brown, N; Covington, W; Ho, DH; Huo, YY; Kuritani, J; Lassere, Y; Pazdur, R | 1 |
| Chimori, Y; Ikoma, H; Miyamoto, Y; Nanri, M; Nishioka, B; Oguro, A; Yamane, E | 1 |
| Ishikawa, K; Kanazawa, T; Kitamura, K; Miyata, M; Nishino, H; Tanaka, H | 1 |
| Abe, O; Demura, H; Endo, M; Kawamura, E; Kimura, K; Kubota, T; Nakao, I; Saito, T; Sasano, H; Sasano, N | 1 |
| Hayashi, K; Kidouchi, K; Kumada, K; Mizokami, M; Orito, E; Sumi, S; Ueda, R; Wada, Y | 1 |
| Chan, KK; Groshen, S; Jeffers, S; Leichman, CG; Leichman, L; Muggia, FM; Spicer, D; Wu, X | 1 |
| Brockstein, BE; Haraf, DJ; Humerickhouse, R; Vokes, EE | 1 |
| Bunnell, CA; Winer, EP | 1 |
| Ajani, JA | 1 |
| Brito, R; Hoff, PM; Medgyesy, D; Pazdur, R; Royce, M | 2 |
| Hohneker, JA | 1 |
| House, LK; Ramírez, J; Ratain, MJ | 1 |
| Adams, ER; Craig, DJ; Leffert, JJ; Pizzorno, G; Spector, T | 1 |
| Meropol, NJ | 1 |
| Shiau, AL; Wu, CL; Wu, P; Yang, HM | 1 |
| Huels, MA; Klyachko, DV; Sanche, L | 1 |
| Brockstein, B; Dolan, ME; Haraf, DJ; Humerickhouse, RA; Kies, M; Ratain, MJ; Stenson, K; Sulzen, L; Vokes, EE | 1 |
| Ichikawa, A; Inada, T; Kawakubo, H; Ogata, Y | 1 |
| Kawabata, Y; Nio, Y; Ohishi, T; Sumi, S; Tamura, K; Yano, S | 1 |
| González Barón, M | 1 |
| Hoshino, K; Ikeda, H; Koyama, T; Morishita, Y; Nakamura, M | 1 |
| Brito, RA; Hoff, PM; Medgyesy, D; Pazdur, R; Ravandi-Kashani, F; Royce, ME; Zukowski, TH | 1 |
| Goto, M; Iwanaga, T; Kitamura, M; Kito, T; Nakajima, T; Nashimoto, A; Okabayashi, K | 1 |
| Ollendorf, D | 1 |
| Colangelo, L; Mamounas, EP; Smith, R; Wickerham, DL; Wieand, HS | 1 |
| Diasio, RB; Hageboutros, A; High, L; Johnson, MR; Smith, JB; Wang, K | 1 |
| Basaki, Y; Chikahisa, L; Hashimoto, A; Miyadera, K; Okabe, S; Wierzba, K; Yamada, Y; Yonekura, K | 1 |
| Fujii, M; Imai, S; Mochizuki, F | 1 |
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| Macdonald, JS | 1 |
| Blanke, CD; Choy, H; Teng, M | 1 |
| Fujinami, K; Kubota, Y | 1 |
| Fujioka, M; Idezuki, Y; Inokuma, S; Ishida, H; Kamano, T; Kishi, T; Kondo, K; Matsumoto, Y; Miura, T; Murata, N; Nakada, H; Odaka, A; Shimomura, K; Suzuki, T; Takeuchi, I; Yamada, H | 1 |
| Boisdron-Celle, M; Delva, R; Gamelin, E; Genevieve, F; Guérin-Meyer, V; Ifrah, N; Larra, F; Lortholary, A; Robert, J | 1 |
| Erdélyi-Tóth, V; Jeney, A; Katona, C; Kovács, P; Kralovánszky, J; Noordhuis, P; Otvös, L; Pandi, E; Peters, GJ; Van der Wilt, CL | 1 |
| Cao, S; Rustum, YM | 1 |
| Bekradda, M; Cvitkovic, E | 1 |
| Hasegawa, K; Kurihara, M; Matsukawa, M; Muto, Y; Sakonji, M; Takebuchi, K; Watanabe, M | 1 |
| Papamichael, D | 1 |
| Fujiwara, Y; Itoh, R; Kusunoki, M; Nakagawa, K; Nakao, K; Yamamura, T | 1 |
| Izumi, S; Nakagawa, J; Nishihara, M; Onoda, Y; Shimizu, N; Shiota, K; Suzuka, I | 1 |
| Aiba, K; Horikoshi, N; Ito, Y; Mizunuma, N; Ohsawa, H; Sugiyama, K; Takahashi, S | 1 |
| Kawaida, M; Kitahara, S; Kohno, N; Ohmuma, T | 1 |
| Musha, N; Oka, K; Saito, H; Sando, N; Sasaki, M; Setu, M; Setu, Y; Sunami, E | 1 |
| Baker, SD; Diasio, RB; Donehower, RC; Grochow, LB; Hohneker, JA; Khor, SP; Lucas, VS; O'Reilly, S; Rowinsky, EK; Sartorius, SE; Spector, T | 1 |
| Ajisaka, H; Bando, E; Fujimura, T; Fushida, S; Hayashi, T; Minatoya, T; Miwa, K; Nishimura, G; Taniguchi, K; Yonemura, Y | 1 |
| Fujitomi, Y; Fujiyoshi, K; Yasue, K | 1 |
| Hoff, PM; Lassere, Y; Pazdur, R | 1 |
| Fujita, M; Furukawa, H; Hirata, K; Kaibara, N; Kakegawa, T; Kasai, Y; Kitamura, M; Kubota, T; Kunii, Y; Nagawa, H; Nose, Y; Takahashi, Y; Takao, T; Takashima, S; Toge, T; Tomita, M; Wakasugi, J | 1 |
| Nashimoto, A; Tanaka, O; Yabusaki, H | 1 |
| Bonny, T; Bukowski, R; Burris, H; Hochster, H; Hohneker, J; Levin, J; Mani, S; O'Rourke, M; Schilsky, RL; Wall, JG | 1 |
| Barton, CM; Cirkel, DT; de Boer, RH; Hickish, TF; Johnston, SR; Norton, A; O'Brien, ME; Smith, IE | 1 |
| Damjanov, N; Meropol, NJ | 1 |
| Hoff, PM; Pazdur, R | 1 |
| Ajani, JA; Yao, JC | 1 |
| Hirakawa, Y; Kawaguchi, Y; Kuwata, K; Matsushima, E; Nagayama, S | 1 |
| Aboagye, EO; Brady, F; Jones, T; Lucas, SV; Osman, S; Price, PM; Saleem, A; Suttle, B; Yap, J | 1 |
| Beck, T; Bell, WN; Chevlen, EM; Hochster, H; Hohneker, J; Levin, J; Lokich, J; Mani, S; McGuirt, C; O'Rourke, MA; Schilsky, RL; Weaver, CH; White, R | 1 |
| Ando, J; Fujisaki, M; Ikeda, T; Imoto, S; Kobayashi, H; Kojima, M; Oka, S; Tamura, H; Wada, N | 1 |
| Fukui, H; Miyama, Y; Takeda, H; Tokuda, C | 1 |
| Ikeda, Y; Mizuno, H; Nishimura, G; Satake, K; Taguchi, T; Tsukuda, M; Yanoma, S | 1 |
| Ikeda, K; Kawaguchi, Y; Masuda, H; Matsushima, E; Nagayama, S; Yoshisue, K | 1 |
| Kusunoki, M; Noda, M; Yamamura, T; Yanagi, H; Yoshikawa, R | 2 |
| Ahmed, F; Bissett, D; Cassidy, J; McLeod, H | 1 |
| Fukuda, J; Hayatsu, M; Hoshina, H; Iida, A; Kaji, M; Miyamoto, T; Miyaura, Y; Nagashima, K; Ono, K; Takagi, R; Tsurumaki, H | 1 |
| Baba, H; Kikunaga, H; Matsudo, A; Miura, H; Morisue, A; Nakai, H; Osakabe, Y; Sotome, K; Takao, M | 1 |
| Asahara, T; Nakahara, H; Nakahara, M; Okajima, M; Yano, M | 1 |
| Kitaoka, A; Ohsumi, K; Tokuka, A; Tokunaga, Y; Yagi, T | 1 |
| Alauddin, MM; Bading, JR; Conti, PS; Fissekis, JD; Joung, J; Shahinian, AH; Spector, T | 1 |
| Tewson, TJ | 1 |
| Aschele, C; Grossi, F; Guglielmi, A; Puglisi, F; Sobrero, A | 1 |
| Peeters, M; Van Cutsem, E | 1 |
| Kindler, HL; Schilsky, RL | 1 |
| Bemi, V; Ipata, PL; Mascia, L; Turchi, G | 1 |
| Shirasaka, T; Taguchi, T; Tsuji, A; Yamamitsu, S | 1 |
| Baccanari, DP; Cao, S; Davis, ST; Paff, MT; Rustum, YM; Spector, T; Tansik, RL | 1 |
| Baker, SD | 1 |
| Hohneker, J; Levin, J | 1 |
| Hamazaki, K; Inagaki, M; Kawashima, T; Morichika, T; Sadamori, H; Shima, Y; Tanaka, N; Uetsuka, H; Yagi, T | 1 |
| Köhne, CH; Peters, GJ | 1 |
| Colangelo, L; Lembersky, BC; Mamounas, EP; Smith, RE; Wieand, HS | 1 |
| Ishizu, K; Makuuchi, H; Sadahiro, S; Suzuki, T; Tajima, T; Tokunaga, N | 1 |
| Bi, DQ; Donavan, S; Grem, JL; Grollman, F; Hamilton, JM; Harold, N; Keith, B; Monahan, BP; Morrison, G; Quinn, MG; Shapiro, J; Takimoto, CH; Zentko, S | 1 |
| Katai, H; Saka, M; Sano, T; Sasako, M | 1 |
| Cohen, D; Drengler, R; Ertel, VP; Hoffman, C; Hsieh, A; Hurwitz, HI; Magnum, S; Monroe, P; Ochoa, L; Petros, WP; Rowinsky, EK; Schwartz, G; Thomas, JP; Wilding, G | 1 |
| Lewis, NL; Meropol, NJ | 1 |
| Harboe, K; Lind, A; Ogreid, D; Todnem, K; Zotova, L | 1 |
| Hoff, PM; Pazdur, R; Royce, ME | 1 |
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| Hayabuchi, N; Ikeda, S; Iwamoto, M; Nagata, S; Niiya, F; Odou, E | 1 |
| Fukunaga, M; Goda, F; Maeba, T; Maeta, H; Mihara, T; Mori, S; Ohkawa, M; Okada, H; Okano, K; Senda, S; Uchida, Y; Usuki, H; Wakabayashi, H | 1 |
| Dwivedy, S; Hoff, PM; Medgyesy, D; Pazdur, R; Royce, ME; Zukowski, TH | 1 |
| Benson, AB | 2 |
| Furuyama, JI; Hashimoto-Tamaoki, T; Kusunoki, M; Noda, M; Yamamura, T; Yanagi, H; Yoshikawa, R | 1 |
| Aoyagi, S; Hisamatsu, T; Ikezawa, T; Matsuoka, K; Mizuno, Y; Motohashi, Y; Nishida, J; Tatsuno, S | 1 |
| Ikeda, S; Iwamoto, M; Nagata, S; Niiya, F; Shirouzu, K | 1 |
| Hollis, D; Mayer, RJ; Meropol, NJ; Niedzwiecki, D; Schilsky, RL | 1 |
| de Bono, JS; Twelves, CJ | 1 |
| Alberts, D; Brooks, D; Damle, B; Ferreira, I; Kaul, S; Pazdur, R; Ravandi, F; Sonnichsen, D; Stewart, D | 1 |
| Gierens, H; März, W; Nauck, M; Wieland, H | 1 |
| Cunningham, D; James, RD | 1 |
| Kubota, T | 1 |
| Baas, F; Haasjes, J; Meinsma, R; Muller, EW; Richel, DJ; van Gennip, AH; van Kuilenburg, AB; Waterham, HR; Zoetekouw, L | 1 |
| Akagi, Y; Kobayashi, H; Matono, K; Miyagi, Y; Nakagawa, M; Nozoe, Y; Ogata, Y; Sasatomi, T; Shirouzu, K | 1 |
| Iwase, H; Kameya, T; Makuuchi, H; Sadahiro, S; Suzuki, T; Tajima, T | 1 |
| Aboagye, EO; Cunningham, VJ; Osman, S; Price, PM; Saleem, A | 1 |
| Bruix, J; Castells, L; El-Hariry, I; Llovet, JM; Peachey, M; Ruff, P; Tassopoulos, N | 1 |
| Dougherty, DS; Grem, JL; Harold, N; Keith, B; Saif, MW; Wilson, RH | 1 |
| Browman, G; Clarke, R; Cooke, A; Cripps, C; Goss, G; Khoo, K; Klaassen, D; Knowling, M; Matthews, S; Seymour, L; Siu, L; Tannock, I | 1 |
| Coleman, R; Cunningham, D | 1 |
| Jones, R; Twelves, C | 1 |
| Borner, M; Maroun, J; Scheithauer, W; Twelves, C; Wilke, H | 1 |
| Aguayo, A; Patt, YZ | 1 |
| Barton, CM; Bonneterre, J; Cirkel, DT; Davidson, NG; Piccart, MJ; Richel, DJ; Skovsgaard, T | 1 |
| Akamo, Y; Hasegawa, M; Manabe, T; Takeyama, H; Teranishi, F | 1 |
| Reimer, P; Rückle-Lanz, H | 1 |
| Higashigawa, M; Kagawa, Y; Kakito, H; Kawasaki, H; Kojima, M; Ohkubo, T; Ooi, A; Sakurai, M | 1 |
| Lokich, J | 1 |
| Aoyagi, H; Fukue, M; Ikezawa, K; Kodaira, Y; Maruyama, T; Matsui, S; Monma, E; Nozue, M; Sakamoto, T; Shidara, S; Shimakura, S; Takada, Y; Yoshida, T | 1 |
| Borner, MM; Caponigro, F; Comella, G; de Boer, RF; de Wit, R; Fumoleau, P; Greim, G; Martin, C; Peters, GJ; Schoffski, P; Sulkes, A; van der Born, K; Wanders, J | 1 |
| Barsotti, C; Ipata, PL | 1 |
| Colwell, B; Conklin, HS; Frye, D; Graham, M; Hortobagyi, GN; Levin, J; McGuirt, C; Rivera, E; Somerville, M; Sutton, L | 1 |
| Koyama, S; Shimoda, S; Takeda, N; Tanaka, N; Tsukahara, A; Yajima, K | 1 |
| Diasio, RB; Johnson, MR; Mattison, LK | 1 |
| Ansari, RH; Bell, WN; Colwell, B; Levin, J; McGuirt, PV; Pazdur, R; Schilsky, RL; Thirlwell, MP; West, WH; White, RL; Wong, A; Yates, BB | 1 |
| Adjei, AA; Alberts, SR; Ames, MM; Atherton, P; Diasio, RB; Erlichman, C; Goldberg, RM; Hanson, LJ; Pitot, HC; Reid, JM; Rubin, J; Sloan, JA; Smith, DA | 1 |
| Holen, KD; Saltz, LB | 1 |
| Aoyagi, K; Basaki, Y; Chikahisa, L; Hashimoto, A; Miyadera, K; Okabe, S; Wierzba, K; Yamada, Y; Yonekura, K | 1 |
| Chen, J; Li, Y; Xu, Z | 1 |
| Ertel, P; Fleming, GF; Janisch, L; Kastrissios, H; Learned-Coughlin, S; Magnum, S; Mani, S; Ratain, MJ; Schilsky, RL; Shepard, DR; Smith, D | 1 |
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| BEN-ISHAI, R; GOLDIN, H; OPPENHEIM, B | 1 |
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| CANTAROW, A; RUPP, JJ | 1 |
| CASTOLDI, GL | 1 |
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| CARABASI, R; JACKSON, LG; WEISS, AJ | 1 |
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| Fu, B; Tian, T; Yan, S; Yang, W; Zhang, K; Zhou, X; Zou, G | 1 |
| Carriat, L; Ciccolini, J; Quaranta, S; Rony, M; Solas, C | 1 |
| de Koning, E; Fan, F; Kumar, S; Li, Y; Liu, X; Sullivan, KE; Yuan, J; Zhang, Y | 1 |
| Andersen, SE; Bergmann, TK; Damkier, P; Esbech, PS; Ewertz, M; Hansen, MR; Paulsen, NH; Pfeiffer, P; Plomgaard, P; Qvortrup, C; Vojdeman, F | 1 |
| Broeren, MAC; Brunsveld, L; Deenen, MJ; Hanrath, MA; Lapré, C; Scharnhorst, V; Streng, AS; van de Kerkhof, D; van den Broek, R; van den Wildenberg, SAH; van Dongen, JLJ | 1 |
| Alarcan, H; Broutin, S; Ciccolini, J; Etienne-Grimaldi, MC; Gautier-Veyret, E; Guitton, J; Haufroid, V; Launay, M; Le Louedec, F; Maillard, M; Narjoz, C; Richard, D; Royer, B; Schmitt, A; Tafzi, N; Thomas, F; Tron, C | 1 |
| Andersen, SE; Bergmann, ML; Bergmann, TK; Bertelsen, B; Bøttger, P; Damkier, P; Feddersen, S; Fruekilde, PBN; Greibe, E; Hoffmann-Lücke, E; Lolas, IBY; Madsen, JS; Mørk, M; Nielsen, CG; Nielsen, HH; Nissen, PH; Paulsen, NH; Petersen, PC; Pfeiffer, P; Plomgaard, P; Qvortrup, C; Ramlov, A; Rossing, M; Spangsberg Holm, H; Vojdeman, FJ | 1 |
| Cats, A; de With, M; Gelderblom, H; Guchelaar, HJ; Knikman, J; Mathijssen, RHJ; Meulendijks, D; Schellens, JHM; Swen, JJ | 1 |
| Boyer, JC; Etienne-Grimaldi, MC; Guitton, J; Haufroid, V; Launay, M; Loriot, MA; Royer, B; Thomas, F | 1 |
| Dar, AH; Ganie, SA; Gul, S; Lone, MN; Mehraj, U; Mir, MA; Sofi, S; Wani, NA; Zargar, MA | 1 |
| Ito, Y; Kobuchi, S; Nakamura, T; Okamura, M; Tsuda, M | 1 |
| Greibe, E; Hoffmann-Lücke, E; Madsen, AT; Nissen, PH; Winther-Larsen, A | 1 |
| Ciccolini, J; Derain, L; Guitton, J; Launay, M; Parant, F; Royer, B; Thomas, F | 1 |
| Chang, I; Chang, WJ; Chen, R; Circelli, J; Harpel, Z; Rivera, J; Wei, R; Wu, S | 1 |
Reviews
116 review(s) available for uracil and fluorouracil
| Article | Year |
|---|---|
Inhibitors of macromolecular synthesis in yeast.
Topics: Acriflavine; Amphotericin B; Anisomycin; Anti-Bacterial Agents; Antineoplastic Agents; Cycloheximide; Dactinomycin; Daunorubicin; Deoxyadenosines; Depression, Chemical; DNA; Ethidium; Fluorouracil; Fungal Proteins; Hydroxyurea; Mitomycins; Nalidixic Acid; Phenazines; Phenylethyl Alcohol; Porfiromycin; Puromycin; RNA; Saccharomyces cerevisiae; Streptonigrin; Sulfanilamides; Triaziquone; Trichothecenes; Uracil | 1975 |
Resistance of mammalian tumour cells toward pyrimidine analogues. A review.
Topics: Animals; Antimetabolites; Azacitidine; Azauridine; Bromouracil; Carcinoma, Ehrlich Tumor; Cell Line; Cricetinae; Cytarabine; Deoxycytidine; Drug Resistance; Fluorouracil; Genetic Code; Leukemia, Experimental; Leukemia, Lymphoid; Mast-Cell Sarcoma; Mice; Mutation; Neoplasms, Experimental; Oncogenic Viruses; Phosphotransferases; Pyrimidines; Sarcoma, Experimental; Selection, Genetic; Thymidine Kinase; Uracil; Virus Replication | 1973 |
Chemical carcinogenesis, chemotherapy: cancer's continuing core challenges--G. H. A. Clowes Memorial Lecture.
Topics: Animals; Antineoplastic Agents; Arginase; Benz(a)Anthracenes; Benzopyrenes; Carcinogens; Cell Division; Cell Transformation, Neoplastic; Deoxyribonucleases; DNA; Fluorouracil; Humans; Liver Neoplasms; Methylcholanthrene; Mice; Mutation; Neoplasms; Neoplasms, Experimental; Nucleosides; Oncogenic Viruses; Orotic Acid; Phenanthrenes; Protein Binding; Pyrimidinones; Rats; Skin Neoplasms; Thymine; Uracil | 1970 |
Pharmacology of viruses.
Topics: Amantadine; Animals; Antiviral Agents; Chick Embryo; Cytarabine; Fluorouracil; Guanidines; Haplorhini; Humans; Idoxuridine; Interferons; Nucleosides; Receptors, Drug; Rifampin; RNA, Transfer; RNA, Viral; Uracil; Viral Proteins; Virus Diseases; Viruses | 1970 |
Solid-state radiation chemistry of DNA and its constituents.
Topics: Bromouracil; Chemical Phenomena; Chemistry; Cold Temperature; DNA; DNA, Bacterial; Electron Spin Resonance Spectroscopy; Electrons; Fluorouracil; Free Radicals; Nucleosides; Nucleotides; Oxidation-Reduction; Purines; Pyrimidines; Uracil | 1982 |
Studies of analogs of fluorinated pyrimidine in Japan.
Topics: Animals; Antineoplastic Agents; Drug Evaluation, Preclinical; Drug Therapy, Combination; Fluorouracil; Humans; Japan; Neoplasms; Neoplasms, Experimental; Tegafur; Uracil | 1981 |
[Metabolic modulation as a method in tumor chemotherapy].
Topics: Antineoplastic Agents; Cytarabine; Fluorouracil; Humans; Methotrexate; Neoplasms; Tegafur; Thymidine; Uracil | 1982 |
Perspective on the design and biochemical pharmacology of inhibitors of thymidylate synthetase.
Topics: Antineoplastic Agents; Deoxyuracil Nucleotides; Deoxyuridine; Fluorodeoxyuridylate; Fluorouracil; Methotrexate; Methyltransferases; Protein Binding; Structure-Activity Relationship; Thymidylate Synthase; Uracil | 1980 |
Degradation of pyrimidines and pyrimidine analogs--pathways and mutual influences.
Topics: Aminoisobutyric Acids; Animals; Antimetabolites; Antimetabolites, Antineoplastic; Aza Compounds; Barbiturates; Biodegradation, Environmental; Biological Transport; Brain; Cricetinae; Cytosine; DNA; Dogs; Fluorouracil; Humans; Kinetics; Mice; Neoplasms; Oxidoreductases; Pyrimidines; Rabbits; Rats; Structure-Activity Relationship; Uracil | 1980 |
Preclinical and clinical aspects of biomodulation of 5-fluorouracil.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cisplatin; Colorectal Neoplasms; DNA, Neoplasm; Fluorouracil; Humans; Idoxuridine; Immunologic Factors; Interferons; Leucovorin; Methotrexate; Mice; Phosphonoacetic Acid; RNA, Neoplasm; Uracil; Uridine; Zidovudine | 1994 |
[Combined chemotherapy with 5-FU+cis-platin or UFT+cisplatin].
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Clinical Trials as Topic; Colorectal Neoplasms; Drug Administration Routes; Drug Administration Schedule; Fluorouracil; Humans; Stomach Neoplasms; Tegafur; Uracil | 1995 |
[Chemotherapy of scirrhous gastric cancer].
Topics: Adenocarcinoma, Scirrhous; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Doxorubicin; Etoposide; Fluorouracil; Humans; Interferon alpha-2; Interferon-alpha; Leucovorin; Levoleucovorin; Mitomycin; Nimustine; Recombinant Proteins; Stomach Neoplasms; Tegafur; Uracil | 1994 |
New anticancer agents in clinical development.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Deoxycytidine; Enzyme Inhibitors; Fluorouracil; Gemcitabine; Humans; Neoplasms; Polysaccharides, Bacterial; Prodrugs; Quinazolines; Tegafur; Thiophenes; Thymidylate Synthase; Uracil | 1995 |
Intraarterial infusion chemotherapy for unresectable hepatic metastases from colorectal cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Liver Neoplasms; Mitomycin; Survival Rate; Tegafur; Uracil | 1996 |
Primary linitis plastica of the rectum: report of four cases and review of the literature.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Disease-Free Survival; Female; Fluorouracil; Humans; Linitis Plastica; Male; Middle Aged; Mitomycins; Prognosis; Rectal Neoplasms; Tegafur; Time Factors; Uracil | 1996 |
The suitability of selected new anticancer agents for infusional therapy and the effects of others on infusional therapy practices.
Topics: Administration, Oral; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Dihydrouracil Dehydrogenase (NADP); Drug Delivery Systems; Enzyme Inhibitors; Fluorouracil; Humans; Infusions, Parenteral; Neoplasms; Oxidoreductases; Topoisomerase I Inhibitors; Uracil | 1995 |
[Clinical use of platinum compounds and fluorinated pyrimidines for lung cancer].
Topics: Antineoplastic Agents; Carboplatin; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Cisplatin; Drug Combinations; Fluorouracil; Humans; Lung Neoplasms; Tegafur; Uracil | 1996 |
Modulation of 5-FU and its related compounds.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Drug Combinations; Fluorouracil; Humans; Neoplasms; Pyridines; Tegafur; Uracil | 1997 |
[Benefits of adjuvant chemotherapy for breast cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Drug Combinations; Female; Fluorouracil; Humans; Lymphatic Metastasis; Methotrexate; Mitomycin; Randomized Controlled Trials as Topic; Tamoxifen; Tegafur; Uracil | 1997 |
Current and future directions in adjuvant combined-modality therapy of rectal cancer.
Topics: Antidotes; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Drug Combinations; Fluorouracil; Forecasting; Humans; Leucovorin; Radiotherapy, Adjuvant; Randomized Controlled Trials as Topic; Rectal Neoplasms; Tegafur; Uracil | 1997 |
UFT: biochemical modulation for 5-fluorouracil (5-FU).
Topics: Antineoplastic Agents; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Clinical Trials, Phase I as Topic; Drug Combinations; Fluorouracil; Humans; Lung Neoplasms; Neoplasms; Tegafur; Uracil | 1997 |
New drugs in the treatment of colorectal carcinoma.
Topics: Antibodies, Monoclonal; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Clinical Trials as Topic; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Tegafur; Thiophenes; Topotecan; Trimetrexate; Uracil | 1998 |
Oral 5-FU alternatives for the treatment of head and neck cancer.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Etoposide; Fluorouracil; Head and Neck Neoplasms; Humans; Hydroxyurea; Neoplasm Recurrence, Local; Tegafur; Uracil | 1998 |
Oral 5-FU analogues in the treatment of breast cancer.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Deoxycytidine; Enzyme Inhibitors; Female; Fluorouracil; Humans; Tegafur; Uracil | 1998 |
Chemotherapy for gastric carcinoma: new and old options.
Topics: Administration, Oral; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Capecitabine; Deoxycytidine; Docetaxel; Drug Combinations; Enzyme Inhibitors; Etoposide; Fluorouracil; Humans; Infusions, Intravenous; Irinotecan; Oxonic Acid; Paclitaxel; Pyridines; Randomized Controlled Trials as Topic; Stomach Neoplasms; Taxoids; Tegafur; Uracil | 1998 |
The oral fluorouracil prodrugs.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Fluorouracil; Humans; Leucovorin; Oxonic Acid; Prodrugs; Pyridines; Tegafur; Uracil | 1998 |
Clinical development of eniluracil: current status.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Drug Administration Schedule; Enzyme Inhibitors; Fluorouracil; Humans; Oxidoreductases; Pancreatic Neoplasms; Treatment Outcome; Uracil | 1998 |
Oral fluoropyrimidines in the treatment of colorectal cancer.
Topics: Administration, Oral; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Enzyme Inhibitors; Fluorouracil; Humans; Oxidoreductases; Pyridines; Tegafur; Uracil | 1998 |
[Gastrointestinal cancer and oral anticancer agents].
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Agents; Camptothecin; Drug Combinations; Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Humans; Irinotecan; Organoplatinum Compounds; Oxonic Acid; Prodrugs; Pyridines; Tegafur; Uracil | 1999 |
[Oral fluoropyrimidines in oncology].
Topics: Administration, Oral; Antidotes; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Clinical Trials as Topic; Combined Modality Therapy; Deoxycytidine; Female; Floxuridine; Fluorouracil; Humans; Leucovorin; Male; Neoplasm Recurrence, Local; Neoplasms; Tegafur; Time Factors; Uracil | 1998 |
Fluoropyrimidines: a critical evaluation.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Breast Neoplasms; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Drug Combinations; Fluorouracil; Humans; Leucovorin; Oxonic Acid; Pyridines; Tegafur; Uracil | 1999 |
Clinical implications of dihydropyrimidine dehydrogenase inhibition.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biological Availability; Dihydrouracil Dehydrogenase (NADP); Drug Evaluation; Enzyme Inhibitors; Fluorouracil; Humans; Neoplasms; Oxidoreductases; Tegafur; Uracil | 1999 |
A review of the pharmacology and clinical activity of new chemotherapy agents for the treatment of colorectal cancer.
Topics: Antineoplastic Agents; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Glutamates; Guanine; Humans; Pemetrexed; Platinum Compounds; Pyridines; Quinazolines; Tegafur; Thiophenes; Uracil | 1999 |
Oral fluoropyrimidines: a closer look at their toxicities.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Deoxycytidine; Fluorouracil; Humans; Tegafur; Uracil | 1999 |
The role of UFT in combined-modality therapy.
Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Combined Modality Therapy; Fluorouracil; Gastrointestinal Neoplasms; Humans; Infusions, Intravenous; Leucovorin; Neoplasms; Radiation-Sensitizing Agents; Tegafur; Uracil | 1999 |
[Combination chemotherapy with 5-FU and low-dose CDDP for urogenital tumors].
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Cisplatin; Combined Modality Therapy; Female; Fluorouracil; Humans; Infusions, Intravenous; Interferon-alpha; Kidney Neoplasms; Male; Tegafur; Uracil; Urinary Bladder Neoplasms | 1999 |
New drugs in therapy of colorectal cancer: preclinical studies.
Topics: Animals; Antimetabolites, Antineoplastic; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Drug Evaluation, Preclinical; Enzyme Inhibitors; Fluorouracil; Folic Acid Antagonists; Humans; Oxidoreductases; Prodrugs; Quinazolines; Tegafur; Thiophenes; Thymidine Phosphorylase; Thymidylate Synthase; Uracil | 1999 |
Oral fluoropoyrimidines.
Topics: Animals; Antimetabolites, Antineoplastic; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Enzyme Inhibitors; Fluorouracil; Folic Acid Antagonists; Humans; Leucovorin; Oxidoreductases; Oxonic Acid; Prodrugs; Pyridines; Tegafur; Uracil | 1999 |
Oxaliplatin: a new therapeutic option in colorectal cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Clinical Trials as Topic; Colorectal Neoplasms; Deoxycytidine; Drug Combinations; Drug Synergism; Fluorouracil; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Tegafur; Thiophenes; Uracil | 1999 |
The use of thymidylate synthase inhibitors in the treatment of advanced colorectal cancer: current status.
Topics: Antineoplastic Agents; Colorectal Neoplasms; Enzyme Inhibitors; Fluorouracil; Humans; Prodrugs; Thymidylate Synthase; Uracil | 1999 |
Tegafur/uracil + calcium folinate in colorectal cancer: double modulation of fluorouracil.
Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Colorectal Neoplasms; Drug Combinations; Fluorouracil; Humans; Leucovorin; Tegafur; Uracil | 1999 |
Oral therapy for colorectal cancer: how to choose.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Agents; Biological Availability; Capecitabine; Colorectal Neoplasms; Decision Making; Deoxycytidine; Enzyme Inhibitors; Fluorouracil; Humans; Leucovorin; Tegafur; Uracil | 2000 |
Dihydropyrimidine dehydrogenase inhibitory fluoropyrimidines: a novel class of oral antineoplastic agents.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Dihydrouracil Dehydrogenase (NADP); Enzyme Inhibitors; Fluorouracil; Humans; Leucovorin; Oxidoreductases; Uracil | 1999 |
Preoperative therapy for local-regional gastric cancer: rationale and review of trials.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Clinical Trials as Topic; Doxorubicin; Etoposide; Fluorouracil; Humans; Methotrexate; Mitomycin; Preoperative Care; Stomach Neoplasms; Tegafur; Uracil | 2000 |
Oral fluoropyrimidines in the treatment of colorectal cancer.
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Fluorouracil; Humans; Pyrimidines; Tegafur; Uracil | 2000 |
Mechanism of action of fluoropyrimidines: relevance to the new developments in colorectal cancer chemotherapy.
Topics: Antimetabolites, Antineoplastic; Colorectal Neoplasms; Fluorouracil; Folic Acid Antagonists; Humans; Leucovorin; Prodrugs; Tegafur; Uracil | 2000 |
Oral fluoropyrimidines in colorectal cancer.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Drug Combinations; Fluorouracil; Humans; Leucovorin; Oxonic Acid; Pyridines; Tegafur; Uracil | 2000 |
Eniluracil: an irreversible inhibitor of dihydropyrimidine dehydrogenase.
Topics: Animals; Antimetabolites, Antineoplastic; Clinical Trials as Topic; Dihydrouracil Dehydrogenase (NADP); Enzyme Inhibitors; Fluorouracil; Humans; Neoplasms; Oxidoreductases; Uracil | 2000 |
Conceptual changes in cancer chemotherapy: from an oral fluoropyrimidine prodrug, UFT, to a novel oral fluoropyrimidine prodrug, S-1, and low-dose FP therapy in Japan.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Combinations; Drug Synergism; Drug Therapy; Fluorouracil; Humans; Oxonic Acid; Prodrugs; Pyridines; Tegafur; Uracil | 2000 |
Preclinical development of eniluracil: enhancing the therapeutic index and dosing convenience of 5-fluorouracil.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Dihydrouracil Dehydrogenase (NADP); Drug Synergism; Enzyme Inhibitors; Fluorouracil; Humans; Oxidoreductases; Uracil | 2000 |
Pharmacology of fluorinated pyrimidines: eniluracil.
Topics: Animals; Antimetabolites, Antineoplastic; Dihydrouracil Dehydrogenase (NADP); Drug Synergism; Enzyme Inhibitors; Fluorouracil; Humans; Oxidoreductases; Uracil | 2000 |
Clinical development of eniluracil/fluorouracil: an oral treatment for patients with solid tumors.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Drug Synergism; Enzyme Inhibitors; Fluorouracil; Humans; Neoplasms; Uracil | 2000 |
UFT: mechanism of drug action.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Drug Resistance, Neoplasm; Drug Therapy, Combination; Fluorouracil; Humans; Tegafur; Thymidylate Synthase; Uracil | 2000 |
Oral DPD-inhibitory fluoropyrimidine drugs.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biological Availability; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Drug Resistance, Neoplasm; Fluorouracil; Humans; Leucovorin; Oxidoreductases; Oxonic Acid; Pyridines; Tegafur; Uracil | 2000 |
[Current status and problem of adjuvant chemotherapy for curatively resected gastric cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Cyclophosphamide; Drug Administration Schedule; Fluorouracil; Gastrectomy; Humans; Melphalan; Meta-Analysis as Topic; Randomized Controlled Trials as Topic; Semustine; Stomach Neoplasms; Tegafur; Uracil | 2000 |
Oral fluoropyrimidines in cancer treatment.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Head and Neck Neoplasms; Humans; Lung Neoplasms; Neoplasms; Pyridines; Stomach Neoplasms; Tegafur; Uracil | 2000 |
[Fluorinated pyrimidines in oral treatment of advanced colorectal cancer].
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Enzyme Inhibitors; Fluorouracil; Humans; Leucovorin; Oxidoreductases; Prodrugs; Pyrimidines; Tegafur; Uracil | 2000 |
Novel oral chemotherapy agents.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Dacarbazine; Deoxycytidine; Fluorouracil; Humans; Irinotecan; Neoplasms; Tegafur; Temozolomide; Uracil | 2000 |
[Recent advances is surgical adjuvant chemotherapy for colorectal cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colorectal Neoplasms; Drug Administration Schedule; Fluorouracil; Humans; Levamisole; Mitomycin; Randomized Controlled Trials as Topic; Semustine; Survival Rate; Tegafur; Uracil; Vincristine | 2000 |
Colorectal cancer: chemotherapy treatment overview.
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Humans; Irinotecan; Leucovorin; Organoplatinum Compounds; Oxaliplatin; Randomized Controlled Trials as Topic; Tegafur; Treatment Outcome; Uracil | 2000 |
Oral eniluracil/5-FU for advanced colon and breast carcinomas.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Breast Neoplasms; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Drug Synergism; Enzyme Inhibitors; Female; Fluorouracil; Forecasting; Humans; Oxidoreductases; Uracil | 2001 |
The oral fluorinated pyrimidines.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Biological Availability; Biotransformation; Capecitabine; Clinical Trials as Topic; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Enzyme Inhibitors; Fluorouracil; Humans; Neoplasms; Oxidoreductases; Prodrugs; Tegafur; Uracil | 2001 |
Integrating the oral fluoropyrimidines into the management of advanced colorectal cancer.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Humans; Irinotecan; Leucovorin; Pyrimidines; Quinazolines; Tegafur; Thiophenes; Uracil | 2001 |
[5-fluorouracil and dihydropyrimidine dehydrogenase].
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Fluorouracil; Humans; Neoplasms; Oxidoreductases; Oxonic Acid; Pyridines; Tegafur; Uracil | 2001 |
New options for outpatient chemotherapy--the role of oral fluoropyrimidines.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Enzyme Inhibitors; Fluorouracil; Humans; Outpatients; Tegafur; Uracil | 2001 |
Oral uracil-tegafur: an alternative to intravenous 5-fluorouracil?
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Clinical Trials as Topic; Fluorouracil; Humans; Injections, Intravenous; Tegafur; Uracil | 2001 |
Answering patients' needs: oral alternatives to intravenous therapy.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Capecitabine; Clinical Trials as Topic; Colorectal Neoplasms; Deoxycytidine; Drug Combinations; Fluorouracil; Humans; Infusions, Intravenous; Patient Satisfaction; Quality of Life; Tegafur; Uracil | 2001 |
Nonsurgical treatment of hepatocellular carcinoma.
Topics: Angiogenesis Inhibitors; Antineoplastic Agents; Capecitabine; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Cryosurgery; Deoxycytidine; Drug Combinations; Ethanol; Fluorouracil; Humans; Hyperthermia, Induced; Infusions, Intra-Arterial; Injections, Intralesional; Interferons; Liver Cirrhosis; Liver Neoplasms; Octreotide; Radiopharmaceuticals; Radiotherapy Dosage; Tamoxifen; Tegafur; Uracil | 2001 |
[New therapeutic options in chemotherapy of advanced colorectal cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Carcinoma; Clinical Trials as Topic; Colorectal Neoplasms; Deoxycytidine; Disease-Free Survival; Fluorouracil; Humans; Irinotecan; Leucovorin; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Tegafur; Thiophenes; Uracil | 2001 |
New therapies, new directions: advances in the systemic treatment of metastatic colorectal cancer.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Fluorouracil; Forecasting; Humans; Irinotecan; Neoplasm Metastasis; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Tegafur; Thiophenes; Trimetrexate; Uracil | 2001 |
[Oral fluoropyrimidines registered for the treatment of metastatic colorectal carcinoma: a possible gain].
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Humans; Leucovorin; Neoplasm Metastasis; Pyrimidines; Tegafur; Uracil | 2002 |
Clinical studies of three oral prodrugs of 5-fluorouracil (capecitabine, UFT, S-1): a review.
Topics: Administration, Oral; Antineoplastic Agents; Capecitabine; Deoxycytidine; Fluorouracil; Humans; Neoplasms; Prodrugs; Pyridines; Tegafur; Treatment Outcome; Uracil | 2002 |
Advances in the treatment of metastatic colorectal cancer.
Topics: Administration, Oral; Antibodies, Monoclonal; Antineoplastic Agents; Camptothecin; Cancer Vaccines; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Drug Administration Schedule; Fluorouracil; Humans; Irinotecan; Liver Neoplasms; Neoplasm Metastasis; Organoplatinum Compounds; Oxaliplatin; Prodrugs; Quinazolines; Randomized Controlled Trials as Topic; Thiophenes; Uracil | 2001 |
[Recent advance in adjuvant therapy for breast cancer].
Topics: Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Clinical Trials as Topic; Female; Fluorouracil; Humans; Lymphatic Metastasis; Mastectomy; Methotrexate; Neoplasm Recurrence, Local; Prognosis; Survival Rate; Tamoxifen; Tegafur; Uracil | 2002 |
[Progress in adjuvant therapy for colorectal cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colorectal Neoplasms; Drug Administration Schedule; Fluorouracil; Humans; Leucovorin; Mitomycin; Radiotherapy, Adjuvant; Rectal Neoplasms; Tegafur; Uracil | 2002 |
Heterotopic ossification in rectal cancer: Rare finding with a novel proposed mechanism.
Topics: Adenocarcinoma; Adult; Antimetabolites, Antineoplastic; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Colectomy; Enzyme Inhibitors; Female; Fibroblast Growth Factor 2; Fluorouracil; Humans; Immunohistochemistry; Neoadjuvant Therapy; Ossification, Heterotopic; Radiotherapy, Adjuvant; Rectal Neoplasms; Transforming Growth Factor beta; Treatment Outcome; Uracil | 2003 |
Palliative treatment of patients with colorectal cancer.
Topics: Antimetabolites, Antineoplastic; Camptothecin; Colorectal Neoplasms; Disease Progression; Enzyme Inhibitors; Fluorouracil; Humans; Irinotecan; Leucovorin; Liver Neoplasms; Palliative Care; Quinazolines; Survival Analysis; Tegafur; Thiophenes; Thymidylate Synthase; Topoisomerase I Inhibitors; Treatment Outcome; Uracil | 2003 |
Practical considerations in the use of oral fluoropyrimidines.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Capecitabine; Clinical Trials as Topic; Colorectal Neoplasms; Deoxycytidine; Drug Combinations; Fluorouracil; Humans; Oxonic Acid; Prodrugs; Pyridines; Tegafur; Uracil | 2003 |
[Oral fluoropyrimidines in the treatment of colorectal carcinoma].
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Humans; Prodrugs; Tegafur; Uracil | 2003 |
[Chemotherapy for colon cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Colonic Neoplasms; Deoxycytidine; Fluorouracil; Humans; Irinotecan; Leucovorin; Organoplatinum Compounds; Oxaliplatin; Randomized Controlled Trials as Topic; Tegafur; Treatment Outcome; Uracil | 2003 |
[Intravenous continuous infusion of fluorouracil for treatment of metastatic colorectal cancer].
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Clinical Trials as Topic; Colorectal Neoplasms; Deoxycytidine; Drug Combinations; Fluorouracil; Humans; Infusions, Intravenous; Oxonic Acid; Prognosis; Pyridines; Tegafur; Thymidylate Synthase; Uracil | 2003 |
[Effect of systemic chemotherapy by 5-FU with low dose CDDP (in the hospital) and UFT with low dose CDDP (in outpatient clinic) in unresectable recurrent colorectal cancer].
Topics: Ambulatory Care Facilities; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Colorectal Neoplasms; Fluorouracil; Home Care Services, Hospital-Based; Hospitals; Humans; Neoplasm Recurrence, Local; Prognosis; Tegafur; Uracil | 2003 |
[Present status of chemotherapy for colorectal cancer in countries outside of Japan].
Topics: Administration, Oral; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Cetuximab; Clinical Trials as Topic; Colorectal Neoplasms; Deoxycytidine; Drug Combinations; Evidence-Based Medicine; Fluorouracil; Humans; Irinotecan; Japan; Leucovorin; Neoplasm Recurrence, Local; Organoplatinum Compounds; Oxaliplatin; Oxonic Acid; Prognosis; Pyridines; Tegafur; United States; Uracil | 2003 |
Clinical and cost-effectiveness of capecitabine and tegafur with uracil for the treatment of metastatic colorectal cancer: systematic review and economic evaluation.
Topics: Antimetabolites, Antineoplastic; Capecitabine; Colorectal Neoplasms; Cost-Benefit Analysis; Deoxycytidine; Drug Therapy, Combination; Fluorouracil; Humans; Neoplasm Metastasis; Tegafur; United Kingdom; Uracil | 2003 |
[Chemotherapy for colorectal carcinoma].
Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Drug Administration Schedule; Drug Combinations; Fluorouracil; Humans; Irinotecan; Leucovorin; Liver Neoplasms; Prospective Studies; Randomized Controlled Trials as Topic; Tegafur; Uracil | 2003 |
New developments in systemic chemotherapy in advanced colorectal cancer.
Topics: Administration, Oral; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Capecitabine; Cetuximab; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Humans; Infusions, Intravenous; Irinotecan; Neoplasm Metastasis; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Tegafur; Thiophenes; Uracil | 2003 |
The role of new agents in the treatment of colorectal cancer.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Cetuximab; Clinical Trials as Topic; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Randomized Controlled Trials as Topic; Survival Analysis; Tegafur; Treatment Outcome; Uracil | 2004 |
Comparative pharmacology of oral fluoropyrimidines: a focus on pharmacokinetics, pharmacodynamics and pharmacomodulation.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Capecitabine; Deoxycytidine; Fluorouracil; Humans; Neoplasms; Prodrugs; Pyrimidinones; Tegafur; Uracil | 2004 |
[Recent progress in chemotherapy for hepatocellular carcinoma].
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Chemotherapy, Adjuvant; Chemotherapy, Cancer, Regional Perfusion; Cisplatin; Disease Progression; Doxorubicin; Drug Interactions; Embolization, Therapeutic; Fluorouracil; Hepatectomy; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Interferon-alpha; Liver Neoplasms; Organoplatinum Compounds; Oxaliplatin; Tamoxifen; Tegafur; Uracil | 2004 |
[Advances in palliative and adjuvant chemotherapy of colon cancer].
Topics: Antineoplastic Agents; Camptothecin; Capecitabine; Chemotherapy, Adjuvant; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Humans; Irinotecan; Leucovorin; Levamisole; Organoplatinum Compounds; Oxaliplatin; Palliative Care; Tegafur; Uracil | 2004 |
[Effectiveness of chemoradiotherapy for three cases of squamous cell anal carcinoma].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Anus Neoplasms; Carcinoma, Squamous Cell; Chemotherapy, Adjuvant; Cisplatin; Combined Modality Therapy; Female; Floxuridine; Fluorouracil; Humans; Lymphatic Metastasis; Middle Aged; Radiotherapy, Adjuvant; Tegafur; Uracil | 2004 |
[Second-line chemotherapy for advanced colorectal cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Drug Administration Schedule; Drug Combinations; Fluorouracil; Humans; Irinotecan; Leucovorin; Quality of Life; Survival Rate; Tegafur; Uracil | 2005 |
Commentary on Wang et al., "Pre-operative chemotherapy with oral tegafur-uracil and leucovorin for rectal cancer" (J Surg Oncol 89: 256-263).
Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials, Phase II as Topic; Combined Modality Therapy; Disease-Free Survival; Drug Combinations; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Preoperative Care; Rectal Neoplasms; Survival Rate; Tegafur; Uracil | 2005 |
[5 -fluoropyrimidines for treatment of biliary tract cancers].
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biliary Tract Neoplasms; Capecitabine; Clinical Trials as Topic; Deoxycytidine; Drug Combinations; Fluorouracil; Humans; Oxonic Acid; Pyridines; Pyrimidines; Tegafur; Uracil | 2006 |
Chemotherapy for colorectal cancer.
Topics: Antimetabolites, Antineoplastic; Camptothecin; Capecitabine; Chemotherapy, Adjuvant; Colorectal Neoplasms; Deoxycytidine; Drug Therapy, Combination; Fluorouracil; Humans; Irinotecan; Leucovorin; Neoplasm Metastasis; Organoplatinum Compounds; Oxaliplatin; Survival Rate; Tegafur; Uracil; Vitamin B Complex | 2005 |
[Adjuvant chemotherapy for colorectal cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colorectal Neoplasms; Drug Combinations; Evidence-Based Medicine; Fluorouracil; Guidelines as Topic; Humans; Leucovorin; Lymph Node Excision; Neoplasm Staging; Survival Rate; Tegafur; Uracil | 2006 |
The clinical and economic benefits of capecitabine and tegafur with uracil in metastatic colorectal cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Colorectal Neoplasms; Cost-Benefit Analysis; Deoxycytidine; Fluorouracil; Humans; Meta-Analysis as Topic; Randomized Controlled Trials as Topic; State Medicine; Tegafur; Treatment Outcome; United Kingdom; Uracil | 2006 |
[Adjuvant treatment of colorectal cancer].
Topics: Age Factors; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Camptothecin; Capecitabine; Chemotherapy, Adjuvant; Colonic Neoplasms; Colorectal Neoplasms; Deoxycytidine; Drug Combinations; Fluorouracil; Humans; Irinotecan; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Prognosis; Tegafur; Uracil | 2006 |
[Pharmacokinetics of S-1].
Topics: Administration, Oral; Adult; Aged; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Female; Fluorouracil; Humans; Kidney; Male; Middle Aged; Neoplasms; Oxonic Acid; Rats; Tegafur; Uracil | 2006 |
[Clinical efficacy of administration with S-1 alone for head and neck carcinoma].
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Clinical Trials, Phase II as Topic; Drug Combinations; Fluorouracil; Head and Neck Neoplasms; Humans; Oxonic Acid; Tegafur; Uracil | 2006 |
[Standard chemotherapy for colonic neoplasms].
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Fluorouracil; Humans; Irinotecan; Leucovorin; Organoplatinum Compounds; Oxaliplatin; Randomized Controlled Trials as Topic; Tegafur; Uracil | 2007 |
Chemotherapy of advanced gastric cancer.
Topics: Adenocarcinoma; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Clinical Trials as Topic; Deoxycytidine; Docetaxel; Drug Combinations; Fluorouracil; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Oxonic Acid; Stomach Neoplasms; Taxoids; Tegafur; Uracil | 2007 |
[Adjuvant chemotherapy for colorectal cancer in Japan-current state and problem areas].
Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemotherapy, Adjuvant; Colonic Neoplasms; Combined Modality Therapy; Drug Administration Schedule; Drug Combinations; Europe; Evidence-Based Medicine; Fluorouracil; Humans; Irinotecan; Japan; Leucovorin; Neoplasm Staging; Oxonic Acid; Practice Guidelines as Topic; Rectal Neoplasms; Tegafur; United States; Uracil | 2007 |
The multidisciplinary management of gastrointestinal cancer. The integration of cytotoxics and biologicals in the treatment of metastatic colorectal cancer.
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Cell Death; Cell Survival; Colorectal Neoplasms; Deoxycytidine; Drug Combinations; ErbB Receptors; Fluorouracil; Humans; Leucovorin; Neoplasm Metastasis; Tegafur; Treatment Outcome; Uracil; Vascular Endothelial Growth Factor A | 2007 |
The role of UFT in advanced gastric cancer.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials, Phase II as Topic; Drug Therapy, Combination; Fluorouracil; Humans; Pyrimidines; Stomach Neoplasms; Tegafur; Uracil | 2008 |
Oral uracil-tegafur plus leucovorin vs fluorouracil bolus plus leucovorin for advanced colorectal cancer: a meta-analysis of five randomized controlled trials.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Diarrhea; Fluorouracil; Humans; Infections; Leucovorin; Leukopenia; Mucositis; Neutropenia; Odds Ratio; Randomized Controlled Trials as Topic; Stomatitis; Survival Analysis; Tegafur; Uracil | 2011 |
Therapeutic usefulness of postoperative adjuvant chemotherapy with Tegafur-Uracil (UFT) in patients with breast cancer: focus on the results of clinical studies in Japan.
Topics: Administration, Oral; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Chemotherapy, Adjuvant; Cisplatin; Clinical Trials as Topic; Deoxycytidine; Drug Combinations; Female; Floxuridine; Fluorouracil; Humans; Japan; Methotrexate; Oxonic Acid; Tegafur; Uracil | 2010 |
[Review of methods for determination of dihydropyrimidine dehydrogenase and possible application in screening previous chemotheraphy with 5-fluorouracil].
Topics: Antineoplastic Agents; Biomarkers; Breath Tests; Capecitabine; Comorbidity; Deoxycytidine; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Humans; Mutation; Neoplasms; Polymorphism, Single Nucleotide; RNA, Messenger; Uracil | 2012 |
Applications of oral fluoropyrimidines in colon cancer: their role and new directions.
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Colonic Neoplasms; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Enzyme Inhibitors; Fluorouracil; Humans; Oxaloacetates; Oxonic Acid; Tegafur; Uracil | 2003 |
TAS-102: a novel antimetabolite for the 21st century.
Topics: Angiogenesis Inhibitors; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Clinical Trials as Topic; Colorectal Neoplasms; Drug Combinations; Drug Resistance, Neoplasm; Fluorouracil; Humans; Neoplasms; Pyrrolidines; Thymine; Treatment Outcome; Trifluridine; Uracil | 2016 |
The Role of Fluoropirimidines in Gastrointestinal Tumours: from the Bench to the Bed.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Clinical Trials as Topic; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Drug Resistance, Neoplasm; Drug Synergism; Fluorouracil; Folic Acid Antagonists; Gastrointestinal Neoplasms; Humans; Molecular Targeted Therapy; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Pyrrolidines; Thymidine Phosphorylase; Thymidylate Synthase; Thymine; Trifluridine; Uracil | 2017 |
Oral versus intravenous fluoropyrimidines for colorectal cancer.
Topics: Administration, Oral; Adult; Antineoplastic Agents; Camptothecin; Capecitabine; Chemotherapy, Adjuvant; Colorectal Neoplasms; Disease-Free Survival; Female; Floxuridine; Fluorouracil; Humans; Injections, Intravenous; Irinotecan; Male; Neoadjuvant Therapy; Organoplatinum Compounds; Palliative Care; Pyridines; Pyrimidines; Randomized Controlled Trials as Topic; Tegafur; Uracil | 2017 |
[Dihydropyrimidine déhydrogenase (DPD) deficiency screening and securing of fluoropyrimidine-based chemotherapies: Update and recommendations of the French GPCO-Unicancer and RNPGx networks].
Topics: Antimetabolites, Antineoplastic; Capecitabine; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; France; Humans; Neoplasms; Phenotype; Practice Guidelines as Topic; Pyrimidines; Uracil | 2018 |
Fluoropyrimidine-induced cardiotoxicity.
Topics: Acetates; Capecitabine; Cardiotoxicity; Cardiovascular Diseases; Drug Combinations; Fluorouracil; Humans; Neoplasms; Pyrimidines; Pyrrolidines; Quinazolines; Thiophenes; Thymine; Trifluridine; Uracil; Uridine | 2018 |
Trifluridine/tipiracil: an emerging strategy for the management of gastrointestinal cancers.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Clinical Trials as Topic; Colonic Neoplasms; Docetaxel; Drug Combinations; Fluorouracil; Gastrointestinal Neoplasms; Humans; Immunotherapy; Indoles; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Pyrrolidines; Quality of Life; Taxoids; Thymine; Trifluridine; Uracil | 2018 |
DPYD genotyping and dihydropyrimidine dehydrogenase (DPD) phenotyping in clinical oncology. A clinically focused minireview.
Topics: Antimetabolites, Antineoplastic; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Genotype; Humans; Medical Oncology; Prodrugs; Uracil | 2022 |
Trials
128 trial(s) available for uracil and fluorouracil
| Article | Year |
|---|---|
[Multicenter cooperative study of pre- and post-operative adjuvant chemotherapy in the treatment of colorectal cancer. North Kyushu Co-operative Study Group for Cancer Chemotherapy].
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colonic Neoplasms; Fluorouracil; Humans; Lymph Nodes; Rectal Neoplasms; Suppositories; Survival Rate; Tegafur; Uracil | 1992 |
Early postoperative chemotherapy following noncurative resection for patients with advanced gastric cancer.
Topics: Aged; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Female; Fluorouracil; Humans; Male; Middle Aged; Mitomycin; Picibanil; Prospective Studies; Proteoglycans; Stomach Neoplasms; Tegafur; Uracil | 1992 |
[Evaluation of UFT administration in patients with ovarian cancer who had no evidence of disease after the initial therapy].
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Drug Administration Schedule; Female; Fluorouracil; Humans; Middle Aged; Ovarian Neoplasms; Reoperation; Tegafur; Uracil | 1990 |
[Controlled study of MQF-OK therapy with FT and with UFT on various advanced gastrointestinal cancers. Hirosaki Cooperative Study Group of Cancer Chemotherapy].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carbazilquinone; Clinical Trials as Topic; Double-Blind Method; Female; Fluorouracil; Gastrointestinal Neoplasms; Humans; Male; Middle Aged; Mitomycin; Mitomycins; Picibanil; Remission Induction; Stomach Neoplasms; Tegafur; Uracil | 1988 |
Clinical trials on UFT in the treatment of head and neck cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Clinical Trials as Topic; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Male; Middle Aged; Tegafur; Uracil | 1985 |
Randomized study with mitomycin C + 5-fluorouracil+cytosine arabinoside (MFC)+5-fluorouracil, MFC+tegafur and uracil (UFT), and MF+UFT in advanced gastric cancer: interinstitutional differences in a multicenter study in Japan.
Topics: Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cytarabine; Drug Administration Schedule; Female; Fluorouracil; Gastrectomy; Humans; Japan; Male; Middle Aged; Mitomycin; Stomach Neoplasms; Survival Rate; Tegafur; Uracil | 1995 |
[Pharmacokinetic study of UFT in cancer patients receiving maintenance dialysis].
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colorectal Neoplasms; Female; Fluorouracil; Humans; Kidney Failure, Chronic; Male; Middle Aged; Postoperative Care; Renal Dialysis; Stomach Neoplasms; Tegafur; Uracil | 1995 |
[5-FU concentrations in the blood and tumor tissue after 5'-DFUR or UFT administration in the patients with uterine cervical cancer].
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Female; Floxuridine; Fluorouracil; Humans; Lymph Nodes; Middle Aged; Tegafur; Uracil; Uterine Cervical Neoplasms | 1995 |
[Combination chemotherapy with FP versus FEP in patients with advanced gastric cancer. Research group of gastric cancer chemotherapy].
Topics: Adenocarcinoma; Aged; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Administration Schedule; Etoposide; Female; Fluorouracil; Humans; Leukopenia; Lymphatic Metastasis; Male; Middle Aged; Proportional Hazards Models; Stomach Neoplasms; Survival Rate; Tegafur; Uracil; Vomiting | 1995 |
[The significance of portal infusion chemotherapy for prevention of recurrence in residual liver after hepatectomy for metastases from colorectal cancer].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Female; Fluorouracil; Hepatectomy; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Infusions, Intravenous; Liver Neoplasms; Male; Middle Aged; Mitomycin; Neoplasm Recurrence, Local; Neoplasm, Residual; Portal Vein; Tegafur; Uracil | 1994 |
Chemo-endocrine therapy for prostate cancer with bone metastasis. Nagasaki Prostate Cancer Research Group.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Doxorubicin; Epirubicin; Ethinyl Estradiol; Fluorouracil; Follow-Up Studies; Humans; Longitudinal Studies; Male; Middle Aged; Multivariate Analysis; Orchiectomy; Prognosis; Proportional Hazards Models; Prostatic Neoplasms; Survival Rate; Tegafur; Uracil | 1994 |
[Randomized controlled trial of MMC + UFT and MMC + 5-FU therapy in advanced gastric cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Fluorouracil; Humans; Mitomycin; Quality of Life; Stomach Neoplasms; Survival Analysis; Tegafur; Uracil | 1994 |
[The usefulness of pre- and immediately postoperative chemotherapy in colorectal cancer].
Topics: Adenocarcinoma; Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colorectal Neoplasms; Fluorouracil; Humans; Infusions, Intravenous; Lymphatic Metastasis; Mitomycin; Postoperative Care; Preoperative Care; Tegafur; Uracil | 1994 |
[A multicenter cooperative study on supplementary chemotherapy of uterocervical cancer. The Kyushu UFT Study Group of Uterocervical Cancer].
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Female; Fluorouracil; Humans; Middle Aged; Survival Rate; Tegafur; Uracil; Uterine Cervical Neoplasms | 1994 |
[A double-blind comparison of FUra plasma concentration by oral (UFT) vs continuous intravenous infusion (5-FU)].
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Double-Blind Method; Fluorouracil; Humans; Infusions, Intravenous; Stomach Neoplasms; Tegafur; Uracil | 1993 |
[Determination of 5-FU tissue concentrations after oral UFT administration in tumors of the head and neck].
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Lymphatic Metastasis; Male; Middle Aged; Tegafur; Uracil | 1996 |
[Neoadjuvant therapy followed by administration of UFT for breast cancer patients].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Drug Combinations; Female; Fluorouracil; Humans; Middle Aged; Remission Induction; Tegafur; Uracil | 1996 |
[Combined chemotherapy with 5-FU and low dose CDDP for advanced or recurrent cancer of the digestive system and home anti-cancer chemotherapy].
Topics: Administration, Oral; Ambulatory Care; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Digestive System Neoplasms; Drug Administration Schedule; Female; Fluorouracil; Home Care Services, Hospital-Based; Humans; Infusion Pumps; Infusions, Intravenous; Male; Neoplasm Recurrence, Local; Quality of Life; Tegafur; Uracil | 1995 |
[Outpatient chemotherapy with continuous infusion of 5-fluorouracil (CI 5-FU) and intravenous bolus leucovorin (IVB LV) in advanced gastrointestinal cancer: the second report].
Topics: Administration, Oral; Aged; Ambulatory Care; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Drug Administration Schedule; Female; Fluorouracil; Gastrointestinal Neoplasms; Home Care Services, Hospital-Based; Humans; Infusion Pumps; Infusions, Intravenous; Injections, Intravenous; Leucovorin; Male; Middle Aged; Quality of Life; Tegafur; Uracil | 1995 |
[Combination chemotherapy with 5-FU and CDDP or CDDP analog for head and neck cancer].
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Squamous Cell; Chemotherapy, Adjuvant; Cisplatin; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Infusions, Intravenous; Male; Middle Aged; Survival Rate; Tegafur; Uracil | 1996 |
Pharmacokinetic, oral bioavailability, and safety study of fluorouracil in patients treated with 776C85, an inactivator of dihydropyrimidine dehydrogenase.
Topics: Absorption; Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biological Availability; Dihydrouracil Dehydrogenase (NADP); Enzyme Activation; Enzyme Inhibitors; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasms; Oxidoreductases; Tissue Distribution; Uracil | 1996 |
A comparative, randomized trial of UFT and 5-fluorouracil in combination with cyclophosphamide and doxorubicin in the treatment of advanced breast cancer patients at The Philippines General Hospital.
Topics: Administration, Oral; Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Doxorubicin; Drug Combinations; Fluorouracil; Humans; Middle Aged; Neoplasm Metastasis; Tegafur; Uracil | 1997 |
Clinical application of biochemical modulation in cancer chemotherapy: biochemical modulation for 5-FU.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Combinations; Fluorouracil; Humans; Japan; Tegafur; Uracil | 1997 |
[Low-dose cisplatin added to continuous infusion of 5-fluorouracil or oral administration of UFT for inoperable advanced or recurrent colorectal cancer].
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Colonic Neoplasms; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasm Recurrence, Local; Rectal Neoplasms; Tegafur; Uracil | 1997 |
Postsurgical sequential methotrexate, fluorouracil, and leucovorin for advanced colorectal carcinoma: a preliminary study.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colonic Neoplasms; Disease-Free Survival; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Leucovorin; Male; Methotrexate; Mitomycin; Postoperative Period; Rectal Neoplasms; Survival Rate; Tegafur; Uracil | 1997 |
Scientific basis for the combination of tegafur with uracil.
Topics: Chemotherapy, Adjuvant; Dose-Response Relationship, Drug; Drug Combinations; Female; Fluorouracil; Gastrectomy; Humans; Intestinal Absorption; Male; Middle Aged; Mitomycin; Postoperative Care; Stomach Neoplasms; Survival Analysis; Tegafur; Uracil | 1997 |
Phase I and pharmacokinetic evaluations of UFT plus oral leucovorin.
Topics: Administration, Oral; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials, Phase I as Topic; Drug Combinations; Fluorouracil; Humans; Leucovorin; Neoplasms; Tegafur; Tetrahydrofolates; Uracil | 1997 |
5-FU or UFT combined with leucovorin for previously untreated metastatic colorectal Ca.
Topics: Adult; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Combinations; Drug Therapy, Combination; Fluorouracil; Humans; Leucovorin; Tegafur; Uracil | 1997 |
UFT plus leucovorin vs 5-FU plus leucovorin for metastatic colorectal cancer.
Topics: Adult; Aged; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Combinations; Drug Therapy, Combination; Fluorouracil; Humans; Leucovorin; Middle Aged; Tegafur; Uracil | 1997 |
Preoperative combined oral UFT plus leucovorin and radiation therapy for rectal cancer.
Topics: Antidotes; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Drug Combinations; Feasibility Studies; Fluorouracil; Humans; Leucovorin; Radiotherapy Dosage; Rectal Neoplasms; Tegafur; Uracil | 1997 |
UFT in combination as adjuvant therapy for breast cancer. Grupo Oncologico de Sevilla Seville, Spain.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cyclophosphamide; Drug Combinations; Female; Fluorouracil; Humans; Methotrexate; Middle Aged; Postmenopause; Prednimustine; Premenopause; Spain; Survival Analysis; Tamoxifen; Tegafur; Uracil | 1997 |
Neoadjuvant therapy with cisplatin/fluorouracil vs cisplatin/UFT in locally advanced squamous cell head and neck cancer.
Topics: Adult; Aged; Alopecia; Anemia; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemotherapy, Adjuvant; Cisplatin; Diarrhea; Drug Combinations; Female; Fluorouracil; Forecasting; Head and Neck Neoplasms; Humans; Male; Middle Aged; Neoplasm Staging; Neutropenia; Prospective Studies; Survival Rate; Tegafur; Treatment Outcome; Uracil | 1997 |
Phase III randomized comparison of postoperative adjuvant chemotherapy with 2-year oral UFT (uracil/tegafur) versus six-cycle CMF (cyclophosphamide/methotrexate/5-fluorouracil) in high-risk node-negative breast cancer patients.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cyclophosphamide; Disease-Free Survival; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Methotrexate; Middle Aged; Tegafur; Uracil | 1998 |
Phase I clinical and pharmacologic study of eniluracil plus fluorouracil in patients with advanced cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Dihydrouracil Dehydrogenase (NADP); Drug Interactions; Enzyme Inhibitors; Female; Fluorouracil; Gas Chromatography-Mass Spectrometry; Half-Life; Humans; Leucovorin; Male; Middle Aged; Neoplasms; Oxidoreductases; Uracil | 1998 |
A crossover study of oral administration of UFT in chronic liver disease: comparison of continuous and intermittent schedules.
Topics: Administration, Oral; Aged; Area Under Curve; Carcinoma, Hepatocellular; Chronic Disease; Cross-Over Studies; Diarrhea; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Gastritis; Gastrointestinal Hemorrhage; Humans; Liver Diseases; Liver Neoplasms; Male; Middle Aged; Nausea; Tegafur; Treatment Outcome; Uracil | 1998 |
Phase III randomized comparison of postoperative adjuvant chemotherapy with 2-year oral uracil/tegafur versus 6-cycle cyclophosphamide/methotrexate/5-fluorouracil in high-risk node-negative breast cancer patients.
Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cyclophosphamide; Female; Fluorouracil; Humans; Methotrexate; Middle Aged; Risk; Survival Analysis; Tegafur; Uracil | 1998 |
Potential of the histoculture drug-response assay to contribute to cancer patient survival.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, Drug; Drug Combinations; Drug Resistance, Neoplasm; Female; Fluorouracil; Humans; Male; Middle Aged; Mitomycin; Multivariate Analysis; Prospective Studies; Stomach Neoplasms; Survival Rate; Tegafur; Tumor Stem Cell Assay; Uracil | 1995 |
Phase I and pharmacokinetic study of oral UFT, a combination of the 5-fluorouracil prodrug tegafur and uracil.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Area Under Curve; Cohort Studies; Diarrhea; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Fatigue; Female; Fluorouracil; Humans; Male; Middle Aged; Nausea; Prodrugs; Tegafur; Uracil; Vomiting | 1996 |
Phase I study of eniluracil, a dihydropyrimidine dehydrogenase inactivator, and oral 5-fluorouracil with radiation therapy in patients with recurrent or advanced head and neck cancer.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Dihydrouracil Dehydrogenase (NADP); Enzyme Inhibitors; Feasibility Studies; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Oxidoreductases; Radiography; Treatment Outcome; Uracil | 1999 |
Adjuvant mitomycin and fluorouracil followed by oral uracil plus tegafur in serosa-negative gastric cancer: a randomised trial. Gastric Cancer Surgical Study Group.
Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Female; Fluorouracil; Gastrectomy; Humans; Infusions, Intravenous; Male; Middle Aged; Mitomycins; Stomach Neoplasms; Survival Rate; Tegafur; Uracil | 1999 |
Impact of uracil/tegafur plus oral calcium folinate on resource utilization.
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Fluorouracil; Health Resources; Health Services; Health Services Research; Hospitalization; Humans; Leucovorin; Outpatients; Tegafur; Uracil | 1999 |
UFT plus calcium folinate vs 5-FU plus calcium folinate in colon cancer.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Disease-Free Survival; Drug Therapy, Combination; Female; Fluorouracil; Follow-Up Studies; Humans; Leucovorin; Male; Middle Aged; Prospective Studies; Survival Rate; Tegafur; Treatment Outcome; Uracil | 1999 |
Using preoperative UFT to predict sensitivity to fluoropyrimidines in colorectal cancer.
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colectomy; Colonoscopy; Colorectal Neoplasms; Disease-Free Survival; Drug Hypersensitivity; Fluorouracil; Humans; Necrosis; Neoplasm Staging; Preoperative Care; Prospective Studies; Survival Rate; Tegafur; Treatment Outcome; Uracil | 1999 |
[Clinical trial of prophylactic hepatic arterial chemotherapy for liver metastases in patients with Dukes' C colorectal cancer].
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Administration Schedule; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Neoplasm Staging; Prospective Studies; Tegafur; Uracil | 1999 |
Correlation between uracil and dihydrouracil plasma ratio, fluorouracil (5-FU) pharmacokinetic parameters, and tolerance in patients with advanced colorectal cancer: A potential interest for predicting 5-FU toxicity and determining optimal 5-FU dosage.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Area Under Curve; Chi-Square Distribution; Chromatography, Liquid; Colorectal Neoplasms; Female; Fluorouracil; Humans; Leucovorin; Linear Models; Male; Middle Aged; Predictive Value of Tests; Prospective Studies; Uracil | 1999 |
[Usefulness of pharmacokinetic modulating chemotherapy (PMC) for the postoperative adjuvant therapy of colorectal carcinoma: a preliminary report].
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Combined Modality Therapy; Drug Administration Schedule; Female; Fluorouracil; Humans; Infusions, Intravenous; Male; Middle Aged; Prognosis; Random Allocation; Tegafur; Uracil | 1999 |
Prognosis after salvage chemotherapy for locally unresectable recurrent squamous cell carcinoma of the head and neck.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Drug Administration Schedule; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Prognosis; Salvage Therapy; Survival Rate; Tegafur; Uracil | 1999 |
Phase I and pharmacologic study of oral fluorouracil on a chronic daily schedule in combination with the dihydropyrimidine dehydrogenase inactivator eniluracil.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Analysis of Variance; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Diarrhea; Dihydrouracil Dehydrogenase (NADP); Dose-Response Relationship, Drug; Drug Administration Schedule; Enzyme Inhibitors; Female; Fluorouracil; Follow-Up Studies; Half-Life; Humans; Male; Metabolic Clearance Rate; Middle Aged; Oxidoreductases; Remission Induction; Tissue Distribution; Uracil | 2000 |
[Interim report of JFMTC study no. 20 on the effectiveness of high dose CDDP plus 5-FU regimen as an adjuvant therapy for far-advanced cancer of the stomach].
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Administration Schedule; Drug Evaluation; Fluorouracil; Humans; Stomach Neoplasms; Survival Rate; Tegafur; Uracil | 2000 |
A multicenter phase II study of a five-day regimen of oral 5-fluorouracil plus eniluracil with or without leucovorin in patients with metastatic colorectal cancer.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Combined Modality Therapy; Disease-Free Survival; Drug Administration Schedule; Enzyme Inhibitors; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Treatment Outcome; Uracil | 2000 |
Low-dose oral fluorouracil with eniluracil as first-line chemotherapy against advanced breast cancer: a phase II study.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Biological Availability; Breast Neoplasms; Drug Administration Schedule; Enzyme Inhibitors; Female; Fluorouracil; Humans; Middle Aged; Treatment Outcome; Uracil | 2000 |
Modulation of fluorouracil tissue pharmacokinetics by eniluracil: in-vivo imaging of drug action.
Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Dihydrouracil Dehydrogenase (NADP); Drug Interactions; Enzyme Inhibitors; Female; Fluorouracil; Gastrointestinal Neoplasms; Half-Life; Humans; Injections, Intravenous; Liver; Male; Middle Aged; Oxidoreductases; Tissue Distribution; Tomography, Emission-Computed; Uracil | 2000 |
Multicenter phase II study to evaluate a 28-day regimen of oral fluorouracil plus eniluracil in the treatment of patients with previously untreated metastatic colorectal cancer.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Disease Progression; Drug Administration Schedule; Drug Synergism; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Metastasis; Outpatients; Treatment Outcome; Uracil | 2000 |
[Randomized comparative study of CMF (cyclophosphamide, methotrexate and 5-fluorouracil) and UFT-tamoxifen regimens as adjuvant chemotherapy after surgery for breast cancer: Tochigi Prefectural Study Group for Post-Breast Cancer Adjuvant Chemotherapy].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cyclophosphamide; Drug Administration Schedule; Female; Fluorouracil; Humans; Lymphatic Metastasis; Methotrexate; Middle Aged; Prospective Studies; Quality of Life; Survival Rate; Tamoxifen; Tegafur; Uracil | 2000 |
Results of pharmacokinetic modulating chemotherapy in combination with hepatic arterial 5-fluorouracil infusion and oral UFT after resection of hepatic colorectal metastases.
Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Synergism; Female; Fluorouracil; Hepatic Artery; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Prospective Studies; Survival Analysis; Tegafur; Treatment Outcome; Uracil | 2000 |
UFT/leucovorin vs 5-FU/leucovorin in colon cancer.
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colonic Neoplasms; Disease-Free Survival; Drug Therapy, Combination; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Tegafur; Treatment Outcome; Uracil | 2000 |
Phase I and pharmacokinetic trial of weekly oral fluorouracil given with eniluracil and low-dose leucovorin to patients with solid tumors.
Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Dihydrouracil Dehydrogenase (NADP); Drug Administration Schedule; Enzyme Inhibitors; Female; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Male; Middle Aged; Neoplasms; Oxidoreductases; Uracil | 2000 |
Pharmacokinetics and bioequivalence of a combined oral formulation of eniluracil, an inactivator of dihydropyrimidine dehydrogenase, and 5-fluorouracil in patients with advanced solid malignancies.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cross-Over Studies; Dihydrouracil Dehydrogenase (NADP); Enzyme Inhibitors; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasms; Oxidoreductases; Therapeutic Equivalency; Uracil | 2000 |
Phase II study of oral eniluracil, 5-fluorouracil, and leucovorin in patients with advanced colorectal carcinoma.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NAD+); Disease Progression; Enzyme Inhibitors; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Thymidylate Synthase; Uracil | 2001 |
Effect of food on the oral bioavailability of UFT and leucovorin in cancer patients.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Biological Availability; Colorectal Neoplasms; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Combinations; Fasting; Female; Fluorouracil; Food; Humans; Leucovorin; Male; Middle Aged; Tegafur; Tetrahydrofolates; Time Factors; Uracil | 2001 |
A phase II trial of oral eniluracil/5-fluorouracil in patients with inoperable hepatocellular carcinoma.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Female; Fluorouracil; Follow-Up Studies; Humans; Liver Neoplasms; Male; Middle Aged; Survival Rate; Uracil | 2001 |
A National Cancer Institute of Canada clinical trials group phase II study of eniluracil (776C85) and oral 5-fluorouracil in patients with advanced squamous cell head and neck cancer.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Canada; Enzyme Inhibitors; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasms, Squamous Cell; Treatment Outcome; Uracil | 2001 |
A phase II study of oral eniluracil/fluorouracil in patients with anthracycline-refractory or anthracycline- and taxane-refractory advanced breast cancer.
Topics: Administration, Oral; Adult; Aged; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Bridged-Ring Compounds; Drug Resistance, Neoplasm; Female; Fluorouracil; Humans; Middle Aged; Taxoids; Treatment Outcome; Uracil | 2001 |
Patient preference and pharmacokinetics of oral modulated UFT versus intravenous fluorouracil and leucovorin: a randomised crossover trial in advanced colorectal cancer.
Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Cross-Over Studies; Female; Fluorouracil; Humans; Injections, Intravenous; Leucovorin; Male; Middle Aged; Patient Satisfaction; Prospective Studies; Surveys and Questionnaires; Tegafur; Uracil | 2002 |
Multicenter phase II study of a 28-day regimen of orally administered eniluracil and fluorouracil in the treatment of patients with anthracycline- and taxane-resistant advanced breast cancer.
Topics: Administration, Oral; Adult; Aged; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Bridged-Ring Compounds; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Fluorouracil; Humans; Infusions, Intravenous; Middle Aged; Patient Compliance; Taxoids; Treatment Outcome; Uracil | 2002 |
Randomized, open-label, phase III study of a 28-day oral regimen of eniluracil plus fluorouracil versus intravenous fluorouracil plus leucovorin as first-line therapy in patients with metastatic/advanced colorectal cancer.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Disease Progression; Drug Administration Schedule; Drug Synergism; Female; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Male; Middle Aged; Neoplasm Metastasis; Proportional Hazards Models; Survival Analysis; Treatment Outcome; Uracil | 2002 |
Comparative pharmacokinetic study of continuous venous infusion fluorouracil and oral fluorouracil with eniluracil in patients with advanced solid tumors.
Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Cross-Over Studies; Dihydrouracil Dehydrogenase (NADP); Enzyme Inhibitors; Female; Fluorouracil; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasms; Oxidoreductases; Uracil | 2002 |
Estimation of the effect of food on the disposition of oral 5-fluorouracil in combination with eniluracil.
Topics: Aged; Antineoplastic Agents; Area Under Curve; Cross-Over Studies; Dihydrouracil Dehydrogenase (NADP); Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Enzyme Inhibitors; Female; Fluorouracil; Food-Drug Interactions; Humans; Intestinal Absorption; Male; Middle Aged; Models, Biological; Oxidoreductases; Population; Therapeutic Equivalency; Uracil | 2002 |
Impact of two weekly schedules of oral eniluracil given with fluorouracil and leucovorin on the duration of dihydropyrimidine dehydrogenase inhibition.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Dihydrouracil Dehydrogenase (NADP); Drug Administration Schedule; Female; Fluorouracil; Humans; Leucovorin; Leukocytes, Mononuclear; Male; Middle Aged; Neoplasms; Oxidoreductases; Time Factors; Uracil | 2002 |
Phase I study of eniluracil and oral 5-fluorouracil in combination with docetaxel in the treatment of patients with metastatic breast carcinoma.
Topics: Administration, Oral; Adult; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Docetaxel; Drug Administration Schedule; Enzyme Inhibitors; Female; Fluorouracil; Humans; Middle Aged; Neoplasm Metastasis; Paclitaxel; Taxoids; Uracil | 2002 |
Oral eniluracil/5-fluorouracil in patients with inoperable hepatocellular carcinoma.
Topics: Administration, Oral; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Diarrhea; Enzyme Inhibitors; Female; Fluorouracil; Humans; Liver Neoplasms; Male; Middle Aged; Treatment Outcome; Uracil | 2002 |
Oral fluoropyrimidines in the treatment of advanced colorectal cancer--results of two consecutive phase II trials.
Topics: Administration, Oral; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Diarrhea; Drug Combinations; Fluorouracil; Humans; Leucovorin; Nausea; Survival Rate; Tegafur; Time Factors; Uracil | 2002 |
Clinical studies of three oral prodrugs of 5-fluorouracil (capecitabine, UFT, S-1): a review.
Topics: Administration, Oral; Antineoplastic Agents; Capecitabine; Deoxycytidine; Fluorouracil; Humans; Neoplasms; Prodrugs; Pyridines; Tegafur; Treatment Outcome; Uracil | 2002 |
Multicenter phase III study of uracil/tegafur and oral leucovorin versus fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Disease-Free Survival; Dose-Response Relationship, Drug; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Neoplasm Metastasis; Quality of Life; Survival Rate; Tegafur; United States; Uracil | 2002 |
Randomized comparative study of tegafur/uracil and oral leucovorin versus parenteral fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Disease-Free Survival; Dose-Response Relationship, Drug; Europe; Female; Fluorouracil; Humans; Infusions, Parenteral; Leucovorin; Male; Middle Aged; Neoplasm Metastasis; Quality of Life; Survival Rate; Tegafur; Uracil | 2002 |
Phase II trial of 5-fluorouracil plus eniluracil in patients with advanced pancreatic cancer: a Southwest Oncology Group study.
Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Diarrhea; Enzyme Inhibitors; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Metastasis; Neutropenia; Pancreatic Neoplasms; Survival; Treatment Outcome; Uracil | 2002 |
A phase I trial of weekly paclitaxel plus prolonged oral eniluracil/5-fluorouracil in patients with refractory malignancies.
Topics: Administration, Oral; Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Drug Administration Schedule; Female; Fluorouracil; Humans; Infusions, Intravenous; Paclitaxel; Treatment Outcome; Uracil | 2002 |
Phase I study of eniluracil, oral 5-fluororacil and gemcitabine in patients with advanced malignancy.
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Female; Fluorouracil; Gemcitabine; Humans; Lymphoma; Male; Middle Aged; Neoplasms; Patients; Uracil | 2002 |
Biochemical modulation of 5-fluorouacil through dihydropyrimidine dehydrogenase inhibition: a Southwest Oncology Group phase II trial of eniluracil and 5-fluorouracil in advanced resistant colorectal cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Antineoplastic Protocols; Colorectal Neoplasms; Confidence Intervals; Dihydrouracil Dehydrogenase (NADP); Enzyme Inhibitors; Female; Fluorouracil; Humans; Male; Middle Aged; Oxidoreductases; Southwestern United States; Survival Rate; Treatment Failure; Uracil | 2002 |
Eastern Cooperative Oncology Group phase II trial (E4296) of oral 5-fluorouracil and eniluracil as a 28-day regimen in metastatic colorectal cancer.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Confidence Intervals; Drug Administration Schedule; Enzyme Inhibitors; Female; Fluorouracil; Humans; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Survival Analysis; Uracil | 2002 |
[Hepatic recurrence after prophylactic hepatic arterial infusion of 5-fluorouracil for Dukes' C colorectal cancer--correlation with the expression of dihydropyrimidine dehydrogenase in the primary tumor].
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Dihydrouracil Dehydrogenase (NADP); Enzyme-Linked Immunosorbent Assay; Fluorouracil; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Neoplasm Recurrence, Local; Oxidoreductases; Tegafur; Uracil | 2002 |
Randomized phase III trial of fluorouracil alone versus fluorouracil plus cisplatin versus uracil and tegafur plus mitomycin in patients with unresectable, advanced gastric cancer: The Japan Clinical Oncology Group Study (JCOG9205).
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Disease-Free Survival; Female; Fluorouracil; Humans; Japan; Male; Middle Aged; Mitomycin; Prospective Studies; Stomach Neoplasms; Survival Rate; Tegafur; Uracil | 2003 |
Pharmacokinetic and pharmacodynamic effects of oral eniluracil, fluorouracil and leucovorin given on a weekly schedule.
Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Area Under Curve; Enzyme Inhibitors; Female; Fluorouracil; Half-Life; Humans; Infusions, Intravenous; Leucovorin; Male; Metabolic Clearance Rate; Middle Aged; Neoplasms; Uracil | 2003 |
Pharmacokinetics of S-1, an oral formulation of ftorafur, oxonic acid and 5-chloro-2,4-dihydroxypyridine (molar ratio 1:0.4:1) in patients with solid tumors.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Area Under Curve; Biological Availability; Dose-Response Relationship, Drug; Drug Combinations; Female; Fluorouracil; Half-Life; Humans; Male; Metabolic Clearance Rate; Middle Aged; Neoplasms; Oxonic Acid; Pyridines; Tegafur; Tissue Distribution; Uracil | 2003 |
Modelling of ftorafur and 5-fluorouracil pharmacokinetics following oral UFT administration. A population study in 30 patients with advanced breast cancer.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Female; Fluorouracil; Humans; Leucovorin; Middle Aged; Models, Biological; Neoplasm Metastasis; Tegafur; Uracil; Vinblastine; Vinorelbine | 2003 |
Prediction of sensitivity to fluoropyrimidines by metabolic and target enzyme activities in gastric cancer.
Topics: Adult; Aged; Aged, 80 and over; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Combined Modality Therapy; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Female; Fluorouracil; Gastrectomy; Humans; Japan; Liver Neoplasms; Lymphatic Metastasis; Male; Mice; Mice, Inbred BALB C; Middle Aged; Multivariate Analysis; Neoplasm Staging; Oxidoreductases; Oxonic Acid; Peritoneal Neoplasms; Predictive Value of Tests; Pyridines; Retrospective Studies; Statistics as Topic; Stomach Neoplasms; Survival Analysis; Tegafur; Thymidine Phosphorylase; Thymidylate Synthase; Treatment Outcome; Uracil | 2003 |
Circadian rhythm of dihydrouracil/uracil ratios in biological fluids: a potential biomarker for dihydropyrimidine dehydrogenase levels.
Topics: Adult; Animals; Biomarkers; Circadian Rhythm; Dihydrouracil Dehydrogenase (NADP); Enzyme-Linked Immunosorbent Assay; Female; Fluorouracil; Humans; Infusions, Intravenous; Liver; Male; Monocytes; Rats; Rats, Sprague-Dawley; Uracil | 2004 |
A Phase I trial of preoperative eniluracil plus 5-fluorouracil and radiation for locally advanced or unresectable adenocarcinoma of the rectum and colon.
Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Colonic Neoplasms; Combined Modality Therapy; Drug Combinations; Enzyme Inhibitors; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Rectal Neoplasms; Uracil | 2004 |
Single ascending dose tolerability, pharmacokinetic-pharmacodynamic study of dihydropyrimidine dehydrogenase inhibitor Ro 09-4889.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Capecitabine; Deoxycytidine; Deoxyuridine; Dihydrouracil Dehydrogenase (NADP); Dose-Response Relationship, Drug; Double-Blind Method; Drug Synergism; Enzyme Inhibitors; Fluorouracil; Humans; Leukocytes, Mononuclear; Male; Models, Chemical; Placebos; Time Factors; Uracil | 2004 |
Randomized controlled trial of the efficacy of adjuvant immunochemotherapy and adjuvant chemotherapy for colorectal cancer, using different combinations of the intracutaneous streptococcal preparation OK-432 and the oral pyrimidines 1-hexylcarbamoyl-5-flu
Topics: Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colectomy; Colonic Neoplasms; Drug Combinations; Female; Fluorouracil; Humans; Injections, Subcutaneous; Male; Middle Aged; Mitomycin; Neoplasm Staging; Picibanil; Pyrimidines; Radiotherapy, Adjuvant; Rectal Neoplasms; Survival Analysis; Tegafur; Treatment Outcome; Uracil | 2004 |
Concurrent and adjuvant chemotherapy for nasopharyngeal carcinoma: a factorial study.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carcinoma; Chemotherapy, Adjuvant; Cisplatin; Combined Modality Therapy; Disease-Free Survival; Female; Fluorouracil; Humans; Infusions, Intravenous; Male; Methotrexate; Middle Aged; Nasopharyngeal Neoplasms; Neoplasm Metastasis; Tegafur; Treatment Outcome; Uracil; Vincristine | 2004 |
Enhanced induction of apoptosis in lung adenocarcinoma after preoperative chemotherapy with tegafur and uracil (UFT).
Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Chemotherapy, Adjuvant; Drug Therapy, Combination; Female; Fluorouracil; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Lung Neoplasms; Male; Middle Aged; Preoperative Care; Prospective Studies; Tegafur; Uracil | 2004 |
Important role of the dihydrouracil/uracil ratio in marked interpatient variations of fluoropyrimidine pharmacokinetics and pharmacodynamics.
Topics: Adult; Antimetabolites, Antineoplastic; Chorionic Gonadotropin; Female; Floxuridine; Fluorouracil; Gestational Trophoblastic Disease; Humans; Leukocyte Count; Metabolic Clearance Rate; Neutrophils; Prodrugs; Prospective Studies; Uracil | 2004 |
Docetaxel (Taxotere), cisplatin, UFT, and leucovorin combination chemotherapy in advanced gastric cancer.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Docetaxel; Drug Combinations; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Neoplasm Staging; Stomach Neoplasms; Survival Analysis; Taxoids; Tegafur; Treatment Outcome; Uracil | 2005 |
How accurate is magnetic resonance imaging in restaging rectal cancer in patients receiving preoperative combined chemoradiotherapy?
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Female; Fluorouracil; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Staging; Predictive Value of Tests; Rectal Neoplasms; Reproducibility of Results; Sensitivity and Specificity; Uracil | 2005 |
Randomized crossover trial of intravenous 5-FU versus oral UFT both modulated by leucovorin: a one-centre experience.
Topics: Administration, Oral; Aged; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Cross-Over Studies; Female; Fluorouracil; Humans; Injections, Intravenous; Leucovorin; Male; Patient Satisfaction; Prospective Studies; Tegafur; Uracil | 2005 |
Phase II study of irinotecan, leucovorin, 5-fluorouracil and tegafur/uracil for metastatic colorectal cancer.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fluorouracil; Follow-Up Studies; Humans; Irinotecan; Leucovorin; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Palliative Care; Survival Analysis; Tegafur; Treatment Outcome; Uracil | 2005 |
[Pharmacokinetic modulating chemotherapy highly effective for colorectal carcinoma metastases to multiple organs].
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Chronotherapy; Colorectal Neoplasms; Drug Combinations; Female; Fluorouracil; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Lung Neoplasms; Lymph Nodes; Lymphatic Metastasis; Male; Middle Aged; Tegafur; Uracil | 2005 |
[Multicenter comparative study of the recurrence-inhibitory effect of oral fluoropyrimidine drugs in patients with colorectal cancer following curative resection].
Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Colectomy; Colonic Neoplasms; Combined Modality Therapy; Disease-Free Survival; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Leukopenia; Lymphatic Metastasis; Male; Middle Aged; Mitomycin; Rectal Neoplasms; Survival Rate; Tegafur; Uracil | 2005 |
[Clinical evaluation of chemotherapy with irinotecan (CPT-11), l-leucovorin (l-LV), 5-fluorouracil (5-FU), and UFT for metastatic or recurrent colorectal cancer].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Irinotecan; Leucovorin; Liver Neoplasms; Male; Middle Aged; Nausea; Rectal Neoplasms; Survival Rate; Tegafur; Uracil; Vomiting, Anticipatory | 2005 |
A phase I study of eniluracil/5-FU in combination with radiation therapy for potentially resectable and/or unresectable cancer of the pancreas and distal biliary tract.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Biliary Tract Neoplasms; Combined Modality Therapy; Enzyme Inhibitors; Female; Fluorouracil; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoadjuvant Therapy; Pancreatic Neoplasms; Radiotherapy; Treatment Outcome; Uracil | 2006 |
Oral uracil and tegafur plus leucovorin compared with intravenous fluorouracil and leucovorin in stage II and III carcinoma of the colon: results from National Surgical Adjuvant Breast and Bowel Project Protocol C-06.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Disease-Free Survival; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Neoplasm Staging; Neoplasms, Second Primary; Quality of Life; Tegafur; Uracil | 2006 |
[A randomized controlled study comparing uracil-tegafur (UFT)+tamoxifen (UFT+TAM therapy) with cyclophosphamide+adriamycin+5-fluorouracil (CAF therapy) for women with stage I , II, or IIIa breast cancer with four or more involved nodes in the adjuvant set
Topics: Anorexia; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Female; Fluorouracil; Humans; Leukopenia; Lymph Nodes; Lymphatic Metastasis; Mastectomy; Middle Aged; Neoplasm Staging; Survival Rate; Tamoxifen; Tegafur; Uracil; Vomiting, Anticipatory | 2006 |
Biweekly oxaliplatin plus 1-day infusional fluorouracil/leucovorin followed by metronomic chemotherapy with tegafur/uracil in pretreated metastatic colorectal cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Administration Schedule; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Neoplasm Metastasis; Organoplatinum Compounds; Oxaliplatin; Patient Selection; Survival Analysis; Tegafur; Uracil | 2007 |
Quality of life in operable colon cancer patients receiving oral compared with intravenous chemotherapy: results from National Surgical Adjuvant Breast and Bowel Project Trial C-06.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colonic Neoplasms; Female; Fluorouracil; Health Status; Humans; Infusions, Intravenous; Leucovorin; Male; Middle Aged; Quality of Life; Tegafur; Uracil | 2007 |
The dihydrouracil/uracil ratios in plasma and toxicities of 5-fluorouracil-based adjuvant chemotherapy in colorectal cancer patients.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Colorectal Neoplasms; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Uracil; Vitamin B Complex | 2007 |
Development of a pharmacokinetic model to optimize the dosage regimen of TS-1, a combination preparation of tegafur, gimeracil and oteracil potassium.
Topics: Administration, Oral; Algorithms; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Computer Simulation; Drug Combinations; Fluorouracil; Humans; Kidney; Kinetics; Models, Biological; Oxonic Acid; Pyridines; Renal Insufficiency; Tegafur; Time Factors; Uracil | 2007 |
Chronopharmacokinetics of oral tegafur and uracil in colorectal cancer patients.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Chronotherapy; Colorectal Neoplasms; Cross-Over Studies; Female; Fluorouracil; Humans; Male; Middle Aged; Tegafur; Therapeutic Equivalency; Uracil | 2008 |
Preoperative chemoradiotherapy for rectal cancer: randomized trial comparing oral uracil and tegafur and oral leucovorin vs. intravenous 5-fluorouracil and leucovorin.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Disease-Free Survival; Drug Administration Schedule; Female; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Male; Middle Aged; Neoplasm Staging; Preoperative Care; Prospective Studies; Radiotherapy Dosage; Rectal Neoplasms; Survival Analysis; Tegafur; Uracil; Vitamin B Complex | 2008 |
Randomized phase II study of cisplatin and 5-FU continuous infusion (PF) versus cisplatin, UFT and vinorelbine (UFTVP) as induction chemotherapy in locally advanced squamous cell head and neck cancer (LA-SCHNC).
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Disease-Free Survival; Fluorouracil; Head and Neck Neoplasms; Humans; Infusions, Intravenous; Middle Aged; Neoplasm Invasiveness; Proportional Hazards Models; Tegafur; Uracil; Vinblastine; Vinorelbine | 2008 |
Improved survival for hepatocellular carcinoma with portal vein tumor thrombosis treated by intra-arterial chemotherapy combining etoposide, carboplatin, epirubicin and pharmacokinetic modulating chemotherapy by 5-FU and enteric-coated tegafur/uracil: a p
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Hepatocellular; Chemotherapy, Cancer, Regional Perfusion; Epirubicin; Etoposide; Female; Fluorouracil; Humans; Infusions, Intra-Arterial; Kaplan-Meier Estimate; Liver Neoplasms; Male; Middle Aged; Neoplasm Staging; Pilot Projects; Portal Vein; Prospective Studies; Severity of Illness Index; Tablets, Enteric-Coated; Tegafur; Time Factors; Treatment Outcome; Uracil; Venous Thrombosis | 2007 |
A clinical pharmacokinetic analysis of tegafur-uracil (UFT) plus leucovorin given in a new twice-daily oral administration schedule.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Biological Availability; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Cross-Over Studies; Diarrhea; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Neoplasm Metastasis; Prodrugs; Sex Factors; Tegafur; Therapeutic Equivalency; Uracil | 2007 |
An anticancer drug sensitivity test to determine the effectiveness of UFT as postoperative adjuvant chemotherapy for patients with stage III colorectal cancer.
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Colorectal Neoplasms; Combined Modality Therapy; Disease-Free Survival; Drug Combinations; Drug Resistance, Neoplasm; Female; Fluorouracil; Follow-Up Studies; Humans; Male; Middle Aged; Multivariate Analysis; Neoplasm Recurrence, Local; Neoplasm Staging; Postoperative Period; Survival Rate; Tegafur; Uracil | 2007 |
Effectiveness of pharmacokinetic modulating chemotherapy combined with cisplatin as induction chemotherapy in resectable locally advanced head and neck cancer: phase II study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Combined Modality Therapy; Disease-Free Survival; Drug Administration Schedule; Female; Fluorouracil; Follow-Up Studies; Gastrointestinal Diseases; Head and Neck Neoplasms; Hematologic Diseases; Humans; Leucovorin; Male; Middle Aged; Radiotherapy, Adjuvant; Remission Induction; Salvage Therapy; Survival Analysis; Tegafur; Treatment Outcome; Uracil | 2008 |
Phase II study of UFT with leucovorin plus hepatic arterial infusion with irinotecan, 5-fluorouracil and leucovorin for non-resectable liver metastases of colorectal cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Irinotecan; Leucovorin; Liver Neoplasms; Male; Middle Aged; Tegafur; Uracil | 2009 |
Oral uracil and tegafur compared with classic cyclophosphamide, methotrexate, fluorouracil as postoperative chemotherapy in patients with node-negative, high-risk breast cancer: National Surgical Adjuvant Study for Breast Cancer 01 Trial.
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cyclophosphamide; Female; Fluorouracil; Humans; Lymphatic Metastasis; Methotrexate; Middle Aged; Neoplasm Staging; Quality of Life; Risk Factors; Tegafur; Uracil | 2009 |
Uracil-tegafur and tamoxifen vs cyclophosphamide, methotrexate, fluorouracil, and tamoxifen in post-operative adjuvant therapy for stage I, II, or IIIA lymph node-positive breast cancer: a comparative study.
Topics: Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Cyclophosphamide; Disease-Free Survival; Female; Fluorouracil; Humans; Lymphatic Metastasis; Mastectomy; Methotrexate; Middle Aged; Neoplasm Staging; Survival Rate; Tamoxifen; Tegafur; Uracil | 2009 |
Efficacy of oral tegafur-uracil (UFT) as adjuvant therapy as compared with classical cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) in early breast cancer: a pooled analysis of two randomized controlled trials (N.SAS-BC 01 trial and CUBC trial).
Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cyclophosphamide; Disease-Free Survival; Female; Fluorouracil; Humans; Methotrexate; Middle Aged; Neoplasm Staging; Receptors, Estrogen; Tegafur; Uracil; Young Adult | 2010 |
[Effects of pharmacokinetic modulation chemotherapy (PMC) using oral UFT and venous 5-FU infusion as adjuvant chemotherapy for intrahepatic cholangiocellular carcinoma].
Topics: Administration, Oral; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Chemotherapy, Adjuvant; Cholangiocarcinoma; Female; Fluorouracil; Humans; Infusions, Intravenous; Male; Middle Aged; Survival Rate; Tegafur; Uracil | 2009 |
Phase I/II study of irinotecan, UFT and leucovorin with hepatic arterial infusion using 5-FU in colorectal cancer patients with unresectable liver metastases.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Disease-Free Survival; Dose-Response Relationship, Drug; Female; Fluorouracil; Humans; Infusions, Intra-Arterial; Irinotecan; Leucovorin; Liver Neoplasms; Male; Maximum Tolerated Dose; Middle Aged; Survival Rate; Tegafur; Treatment Outcome; Uracil | 2011 |
Final results of a prematurely discontinued Phase 1/2 study of eniluracil with escalating doses of 5-fluorouracil administered orally in patients with advanced hepatocellular carcinoma.
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Asian People; Carcinoma, Hepatocellular; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Fluorouracil; Humans; Liver Neoplasms; Male; Maximum Tolerated Dose; Middle Aged; Treatment Outcome; Uracil | 2011 |
Phenylbutyrate mouthwash mitigates oral mucositis during radiotherapy or chemoradiotherapy in patients with head-and-neck cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy; Cisplatin; Double-Blind Method; Eating; Female; Fluorouracil; Head and Neck Neoplasms; Histone Deacetylase Inhibitors; Humans; Male; Middle Aged; Mitomycin; Mouthwashes; Phenylbutyrates; Pilot Projects; Radiation Injuries; Radiotherapy Dosage; Stomatitis; Taiwan; Tegafur; Uracil; Weight Loss | 2012 |
High-dose radiotherapy (60 Gy) with oral UFT/folinic acid and escalating doses of oxaliplatin in patients with non-resectable locally advanced rectal cancer (LARC): a phase I trial.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy; Feasibility Studies; Female; Fluorouracil; Follow-Up Studies; Gamma Rays; Humans; Leucovorin; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Radiotherapy Dosage; Rectal Neoplasms; Survival Rate; Tegafur; Treatment Outcome; Uracil | 2012 |
5-Fluorouracil, mitomycin-c, and polysaccharide-k versus uracil-ftorafur and polysaccharide-K as adjuvant chemoimmunotherapy for patients with locally advanced gastric cancer with curative resection.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Fluorouracil; Humans; Immunotherapy; Male; Middle Aged; Mitomycin; Prevalence; Proteoglycans; Republic of Korea; Risk Factors; Stomach Neoplasms; Survival Rate; Tegafur; Treatment Outcome; Uracil | 2013 |
Eniluracil plus 5-fluorouracil and leucovorin: treatment for metastatic breast cancer patients in whom capecitabine treatment rapidly failed.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Deoxycytidine; Female; Fluorouracil; Humans; Leucovorin; Middle Aged; Neoplasm Metastasis; Treatment Failure; Uracil | 2014 |
Randomised phase III trial of adjuvant chemotherapy with oral uracil and tegafur plus leucovorin versus intravenous fluorouracil and levofolinate in patients with stage III colorectal cancer who have undergone Japanese D2/D3 lymph node dissection: final r
Topics: Administration, Intravenous; Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colorectal Neoplasms; Disease-Free Survival; Female; Fluorouracil; Humans; Japan; Leucovorin; Lymph Node Excision; Male; Middle Aged; Neoplasm Staging; Tegafur; Uracil; Young Adult | 2014 |
Maintenance treatment of Uracil and Tegafur (UFT) in responders following first-line fluorouracil-based chemotherapy in metastatic gastric cancer: a randomized phase II study.
Topics: Adult; Aged; Disease-Free Survival; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Metastasis; Stomach Neoplasms; Tegafur; Uracil; Young Adult | 2017 |
Randomized Controlled Trial of Adjuvant Chemotherapy with Fluoropyrimidines
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Staging; Stomach Neoplasms; Survival Analysis; Tegafur; Uracil | 2017 |
Other Studies
750 other study(ies) available for uracil and fluorouracil
| Article | Year |
|---|---|
Antitumor agents. 25. Synthesis and antitumor activity of uracil and thymine alpha-methylene-gamma-lactones and related derivatives.
Topics: Animals; Antineoplastic Agents; Carcinoma 256, Walker; Lactones; Leukemia, Experimental; Male; Melanoma; Mice; Neoplasms, Experimental; Rats; Thymine; Uracil | 1977 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Novel nucleosides as potent influenza viral inhibitors.
Topics: Animals; Antiviral Agents; Cell Line; Dogs; Humans; Influenza A virus; Influenza B virus; Influenza, Human; Purine Nucleosides; Pyrimidine Nucleosides; Structure-Activity Relationship | 2010 |
[Uridine kinase, its structure, properties and biological function].
Topics: Animals; Azacitidine; Brain; Carcinoma, Ehrlich Tumor; Chick Embryo; Drug Resistance; Fluorouracil; Isoenzymes; Kinetics; Liver; Phosphotransferases; Rats; RNA; Sarcoma, Experimental; Uracil; Uridine Kinase | 1978 |
The effects of 5-fluorouracil and 5-fluorodeoxyuridine used alone and in combination with normal nucleic acid precursors on development of mice in lines selected for low and high expression of Strong's luxoid gene.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Cell Survival; Drug Synergism; Female; Fetal Death; Floxuridine; Fluorouracil; Forelimb; Genes; Hindlimb; Mice; Mutation; Nucleic Acids; Pregnancy; Protein Precursors; Thymidine; Thymine; Tibia; Toes; Uracil | 1975 |
Free radicals formed by exposure of pyrimidine solids to sodium atoms: an electron spin resonance study.
Topics: Alloxan; Bromouracil; Cytosine; Electron Spin Resonance Spectroscopy; Fluorouracil; Free Radicals; Pyrimidines; Sodium; Thymine; Uracil | 1975 |
E.s.r. studies of halogenated pyrimidines in gamma-irradiated alkaline glasses.
Topics: Bromouracil; Cobalt Radioisotopes; Dose-Response Relationship, Radiation; Electron Spin Resonance Spectroscopy; Fluorouracil; Free Radicals; Gamma Rays; Glass; Radiation Effects; Uracil | 1975 |
The nature of the miscoding caused by growth in the presence of 2-thiouracil.
Topics: Bacterial Proteins; Codon; Escherichia coli; Fluorouracil; Mutation; Phenotype; RNA, Bacterial; RNA, Messenger; Salmonella typhimurium; Thiouracil; Uracil | 1977 |
Comparison of the actions of 5-fluorouracil and ftorafur in Escherichia coli.
Topics: Drug Resistance, Microbial; Escherichia coli; Fluorouracil; Tegafur; Time Factors; Uracil | 1977 |
Isolation of Escherichia coli mutants with changed regulation of uracil uptake.
Topics: Arginine; Biological Transport; Escherichia coli; Fluorouracil; Genes; Mutation; Ornithine Carbamoyltransferase; Streptomycin; Uracil | 1978 |
Effect of coadministration of uracil or cytosine on the anti-tumor activity of clinical doses of 1-(2-tetrahydrofuryl)-5-fluorouracil and level of 5-fluorouracil in rodents.
Topics: Administration, Oral; Animals; Cytosine; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred ICR; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Sarcoma 180; Tegafur; Tissue Distribution; Uracil | 1979 |
Effect of uracil on metabolism of 5-fluorouracil in vitro.
Topics: Animals; Drug Interactions; Fluorouracil; In Vitro Techniques; Liver; Phosphorylation; Rats; Rats, Inbred Strains; Sarcoma, Yoshida; Uracil | 1979 |
Formation of dUMP-containing DNA by Brij-58 lysed CHO cells.
Topics: Animals; Cell Line; Cricetinae; Deoxyuracil Nucleotides; DNA; Female; Fluorouracil; Ovary; Surface-Active Agents; Thymidine; Uracil | 1979 |
Effect of uracil and its derivatives on antitumor activity of 5-fluorouracil and 1-(2-tetrahydrofuryl)-5-fluorouracil.
Topics: Animals; Drug Therapy, Combination; Fluorouracil; Liver Neoplasms, Experimental; Male; Mice; Rats; Sarcoma 180; Staphylococcus aureus; Uracil | 1978 |
Thermoluminescent properties of crystalline halogen substituted uracils.
Topics: Bromouracil; Fluorouracil; Freezing; Hot Temperature; Luminescent Measurements; Radiation Effects; Ultraviolet Rays; Uracil; X-Rays | 1975 |
Studies on a pyrimidine phosphoribosyltransferase from murine leukemia P1534J. Partial purification, substrate specificity, and evidence for its existence as a bifunctional complex with orotidine 5-phosphate decarboxylase.
Topics: Animals; Carbon Radioisotopes; Carboxy-Lyases; Carboxylic Acids; Cells, Cultured; Centrifugation, Density Gradient; Chromatography, DEAE-Cellulose; Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; Fluorouracil; Hot Temperature; Kinetics; Leukemia, Experimental; Mice; Orotic Acid; Pentosyltransferases; Peptide Hydrolases; Phosphoribosyl Pyrophosphate; Pyrimidines; Uracil; Uracil Nucleotides; Uridine Phosphorylase | 1975 |
Letter: Fluorine control of regioselectivity in photocycloaddition reactions. The direct functionalization of uracil via a novel 1,4-fragmentation.
Topics: Cyclization; Fluorouracil; Photochemistry; Uracil | 1976 |
[Concentration of 5-fluorouracil in the blood and tissues of gastric and colo-rectal cancer patients after oral administration of UFT].
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Fluorouracil; Humans; Lymph Nodes; Stomach Neoplasms; Tegafur; Uracil | 1992 |
[Blood concentrations of futraful, uracil and 5-fluorouracil (5-FU) after UFT administration in the various reconstructions after gastrectomy. Saitama UFT Research Group].
Topics: Anastomosis, Roux-en-Y; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Fluorouracil; Gastrectomy; Humans; Postoperative Period; Stomach Neoplasms; Tegafur; Uracil | 1992 |
[A study of urinary tegafur, 5-fluorouracil (5-FU) and uracil concentrations in the cases of gastric carcinoma for the confirmation of drug-taking compliance after UFT oral administration].
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Compliance; Fluorouracil; Gastrectomy; Humans; Postoperative Period; Stomach Neoplasms; Tegafur; Uracil | 1992 |
[Chemosensitivity of head and neck squamous cell carcinomas using subrenal capsule assay--comparative assay of 5-FU, FT, UFT, and HCFU and immunohistochemical study].
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Fluorouracil; Head and Neck Neoplasms; Immunohistochemistry; Male; Mice; Mice, Inbred C3H; Subrenal Capsule Assay; Tegafur; Uracil | 1992 |
Correlation between dihydropyrimidine dehydrogenase activity in peripheral mononuclear cells and systemic clearance of fluorouracil in cancer patients.
Topics: Adult; Aged; Aged, 80 and over; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouracil; Head and Neck Neoplasms; Humans; Lymphocytes; Male; Middle Aged; Oxidoreductases; Uracil | 1992 |
Evaluation of the SOS chromotest for the detection of antimutagens.
Topics: Ascorbic Acid; Benzaldehydes; Colorimetry; Fluorouracil; Glutathione; Mutagenicity Tests; Mutagens; Selenium; Sodium Selenite; SOS Response, Genetics; Uracil | 1991 |
[Thymidylate synthase inhibition and concentration of 5-fluorouracil after administration of UFT in human uroepithelial carcinomas].
Topics: Adenocarcinoma, Mucinous; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Transitional Cell; Female; Fluorouracil; Humans; Male; Middle Aged; Tegafur; Thymidylate Synthase; Tissue Distribution; Uracil; Ureteral Neoplasms; Urinary Bladder Neoplasms | 1991 |
Broad-spectrum antiviral and cytocidal activity of cyclopentenylcytosine, a carbocyclic nucleoside targeted at CTP synthetase.
Topics: Adenosine; Amides; Antiviral Agents; Azauridine; Carbon-Nitrogen Ligases; Cell Division; Cytarabine; Cytidine; Deoxycytidine; Drug Synergism; Fluorouracil; HeLa Cells; Humans; Ligases; Nucleosides; Pyrazoles; Ribavirin; Ribonucleosides; Ribose; Thymidine; Tumor Cells, Cultured; Uracil; Virus Replication; Viruses | 1991 |
Concentration of 5-fluorouracil in renal cells from cancer patients administered a mixture of 1-(2-tetrahydrofuryl)-5-fluorouracil and uracil.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Fluorouracil; Humans; Kidney; Kidney Neoplasms; Tegafur; Uracil | 1991 |
Inhibition of fluoropyrimidine catabolism by benzyloxybenzyluracil. Possible relevance to regional chemotherapy.
Topics: Animals; Floxuridine; Fluorouracil; Liver; Male; Perfusion; Rats; Rats, Inbred Strains; Uracil | 1991 |
[Comparative studies on the antitumor activity of fluorinated pyrimidine derivatives against human bladder, cervical and ovarian cancer xenografts in nude mice].
Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Female; Floxuridine; Fluorouracil; Humans; Mice; Mice, Nude; Ovarian Neoplasms; Tegafur; Uracil; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms | 1991 |
[Regional immunochemotherapy for liver metastasis of esophageal cancer in a patient with variant hepatic artery].
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Combined Modality Therapy; Esophageal Neoplasms; Fluorouracil; Hepatic Artery; Humans; Infusion Pumps; Infusions, Intra-Arterial; Injections, Intramuscular; Liver Neoplasms; Male; Middle Aged; Picibanil; Tegafur; Uracil | 1991 |
[Studies on 5-FU concentration in serum and prostate cancer tissue after oral administration of UFT].
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Fluorouracil; Humans; Male; Prostatectomy; Prostatic Neoplasms; Tegafur; Uracil | 1991 |
Low uracil concentration in the liver might be responsible for the decreased antineoplastic activity of fluoropyrimidines in mice with CCl4-induced chronic liver dysfunction.
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Drug Resistance; Fibrosarcoma; Fluorouracil; Liver; Mice; Mice, Inbred BALB C; Plasmacytoma; Tumor Cells, Cultured; Uracil | 1991 |
[Usage of urine FT levels for medication compliance in head and neck cancer with administration of UFT].
Topics: Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Male; Middle Aged; Tegafur; Uracil | 1990 |
[Tissue UFT distribution and histological changes following UFT administration in metastatic liver cancer cases].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Female; Fluorouracil; Humans; Liver; Liver Neoplasms; Male; Middle Aged; Tegafur; Uracil | 1990 |
[Macrocytic anemia as a possible adverse effect of fluoropyrimidines].
Topics: Anemia, Macrocytic; Antineoplastic Combined Chemotherapy Protocols; Erythrocyte Indices; Female; Fluorouracil; Folic Acid; Humans; Male; Retrospective Studies; Stomach Neoplasms; Tegafur; Uracil; Vitamin B 12 | 1990 |
[Evaluation of subselective intraarterial infusion chemotherapy in advanced gastric cancer and recurrence case-evaluated on factors other than direct effects].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Doxorubicin; Drug Administration Schedule; Female; Fluorouracil; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Lymphatic Metastasis; Male; Middle Aged; Mitomycin; Mitomycins; Neoplasm Recurrence, Local; Quality of Life; Stomach Neoplasms; Tegafur; Uracil | 1990 |
[Results of prophylactic intra-arterial infusion chemotherapy after hepatic resection in colorectal metastases].
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Fluorouracil; Hepatectomy; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Liver Neoplasms; Mitomycin; Mitomycins; Neoplasm Recurrence, Local; Postoperative Care; Tegafur; Uracil | 1990 |
[Effects of combination chemotherapy with topical application of 5-FU ointment to mice's tongue and UFT].
Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Fluorouracil; Liver; Male; Mice; Ointments; Tegafur; Tongue; Uracil | 1990 |
[Combination chemotherapy of human renal cell carcinoma in athymic nude mice with human lymphoblastoid interferon (HLBI) and UFT, 5-Fu].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Combined Modality Therapy; Drug Screening Assays, Antitumor; Fluorouracil; Humans; Interferon Type I; Kidney Neoplasms; Mice; Mice, Nude; Neoplasm Transplantation; Tegafur; Uracil | 1990 |
[Chemotherapy with fluoropyrimidines for MOPC-104E plasmacytoma transplanted in mice with CCl4 induced chronic liver dysfunction].
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Floxuridine; Fluorouracil; Male; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Plasmacytoma; Tegafur; Uracil | 1990 |
Biochemical modulation of 5-fluoropyrimidine toxicity by dehydroepiandrosterone in human colonic adenocarcinoma cells.
Topics: Adenocarcinoma; Carbon Radioisotopes; Colonic Neoplasms; Dehydroepiandrosterone; Fluorouracil; Humans; Interphase; Pyrimidines; Thymidine; Thymidine Monophosphate; Tumor Cells, Cultured; Uracil | 1990 |
The FUR1 gene of Saccharomyces cerevisiae: cloning, structure and expression of wild-type and mutant alleles.
Topics: Alleles; Amino Acid Sequence; Base Sequence; Chromosome Deletion; Cloning, Molecular; DNA Mutational Analysis; DNA, Recombinant; Fluorouracil; Genes, Fungal; Molecular Sequence Data; Orotate Phosphoribosyltransferase; Pentosyltransferases; Plasmids; Saccharomyces cerevisiae; Uracil; Uridine Monophosphate | 1990 |
[Antitumor activity of UFT against murine renal cell carcinoma: a study on the suppression tumor metastases].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Drug Screening Assays, Antitumor; Female; Fluorouracil; Kidney Neoplasms; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; Survival Rate; Tegafur; Uracil | 1990 |
[Transformation of ovarian yolk sac tumor to immature teratoma following chemotherapy].
Topics: Adult; alpha-Fetoproteins; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Female; Fluorouracil; Humans; Mesonephroma; Mitomycin; Mitomycins; Ovarian Neoplasms; Tegafur; Teratoma; Uracil | 1985 |
[Combined chemotherapy and radiotherapy in recurrent tumors of the head and neck region].
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Combined Modality Therapy; Cyclophosphamide; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Male; Methotrexate; Neoplasm Recurrence, Local; Radiotherapy Dosage; Tegafur; Uracil | 1987 |
[Long-term administration of tegafur in postoperative adjuvant chemotherapy in gastric cancer patients. Serial analysis of serum tegafur and 5-fluorouracil concentrations, and influence from PSK combination].
Topics: Adjuvants, Immunologic; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Female; Fluorouracil; Gastrectomy; Humans; Male; Middle Aged; Proteoglycans; Stomach Neoplasms; Tegafur; Time Factors; Uracil | 1989 |
[Experimental study on the effect of UFT with concomitant radiotherapy of uterine cervical cancer].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bromodeoxyuridine; Carcinoma, Squamous Cell; Cell Division; Cell Line; Combined Modality Therapy; DNA Polymerase II; Female; Fluorouracil; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Tegafur; Tumor Cells, Cultured; Uracil; Uterine Cervical Neoplasms | 1989 |
5-Fluorouracil and UFT-sensitive gastric carcinoma has a high level of thymidylate synthase.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Fluorouracil; Humans; Male; Mice; Mice, Inbred C3H; Stomach Neoplasms; Subrenal Capsule Assay; Tegafur; Thymidylate Synthase; Uracil | 1989 |
[The concentration of 5-fluorouracil in blood and tissues of the patients with carcinoma of the cervix after administration of UFT and 5-fluorouracil].
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Female; Fluorouracil; Humans; Middle Aged; Tegafur; Tissue Distribution; Uracil; Uterine Cervical Neoplasms | 1989 |
[Influence of OK-432 on intratumor 5-fluorouracil concentration in cases given UFT].
Topics: Antineoplastic Combined Chemotherapy Protocols; Biological Products; Biotransformation; Colonic Neoplasms; Fluorouracil; Humans; Lymphatic Metastasis; Picibanil; Stomach Neoplasms; Tegafur; Tissue Distribution; Uracil | 1989 |
Pharmacokinetic modulation of plasma 5-fluorouracil concentrations to potentiate the antitumor activity of continuous venous infusion of 5-fluorouracil.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Circadian Rhythm; Drug Synergism; Fluorouracil; Infusions, Intravenous; Kinetics; Leukocyte Count; Pyridines; Rats; Sarcoma, Yoshida; Tegafur; Uracil | 1989 |
[Anti-tumor effect of fluoropyrimidines on human tumor cell lines transplanted in nude mice with CCl4-induced liver dysfunction].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carbon Tetrachloride; Cell Line; Colonic Neoplasms; Fluorouracil; Humans; Liver Cirrhosis, Experimental; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Stomach Neoplasms; Tegafur; Transplantation, Heterologous; Uracil | 1989 |
[Effect of uracil on the both reactions, 5-fluorouracil degradation into 2-fluoro-beta-alanine and 5-fluorouracil splitting from tegafur in human tumor].
Topics: Adenocarcinoma, Papillary; Alanine; beta-Alanine; Fluorouracil; Humans; Lung Neoplasms; Tegafur; Tumor Cells, Cultured; Uracil | 1989 |
Adjuvant effects of calmodulin antagonists on antitumor activity of 1-(2-tetrahydrofuryl)-5-fluorouracil (ftorafur) and a mixture of ftorafur and uracil (UFT) in nude mice bearing human ovarian carcinomas.
Topics: Animals; Calmodulin; Carcinoma; Drug Combinations; Drug Synergism; Female; Fluorouracil; Mice; Mice, Nude; Neoplasm Transplantation; Ovarian Neoplasms; Sulfonamides; Tegafur; Time Factors; Uracil | 1989 |
[Combination effect of UFT and gamma-irradiation against nude mice transplanted KB cells].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Fluorouracil; Gamma Rays; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Mouth Neoplasms; Neoplasm Transplantation; Tegafur; Uracil | 1989 |
[Study on the concentrations of 5-fluorouracil (5-FU), tegafur (ET) and uracil in bile: comparison of UFT or FT].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bile; Biliary Tract Neoplasms; Cholestasis; Female; Fluorouracil; Humans; Male; Middle Aged; Tegafur; Uracil | 1989 |
[The serum and tissue concentration of FT-207, 5'-DFUR and 5-FU in patients with breast cancer by preoperative administration of UFT and 5'-DFUR].
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast; Breast Neoplasms; Floxuridine; Fluorouracil; Humans; Lymph Nodes; Preoperative Care; Tegafur; Tissue Distribution; Uracil | 1989 |
[Level of inhibition of thymidylate synthase activity and 5-fluorouracil in tumor tissues after administration of UFT or tegafur].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Female; Fluorouracil; Mice; Mice, Nude; Specific Pathogen-Free Organisms; Tegafur; Thymidylate Synthase; Uracil; Uterine Neoplasms | 1989 |
[Study on the pharmacokinetics of UFT in patients with hepatocellular carcinoma associated with cirrhosis].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Female; Fluorouracil; Humans; Liver; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged; Tegafur; Thymidylate Synthase; Uracil | 1989 |
[Preoperative chemotherapy for head and neck cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cisplatin; Fluorouracil; Head and Neck Neoplasms; Humans; Infusions, Intra-Arterial; Maxillary Neoplasms; Mouth Neoplasms; Peplomycin; Pharyngeal Neoplasms; Preoperative Care; Tegafur; Uracil | 1985 |
The effect of histidine on the structure and antitumor activity of metal-5-halouracil complexes.
Topics: Animals; Bromouracil; Cadmium; Cobalt; Copper; Fluorouracil; Histidine; Lymphoma; Magnetics; Manganese; Mice; Mice, Inbred C3H; Molecular Structure; Nickel; Spectrophotometry; Structure-Activity Relationship; Uracil; Zinc | 1989 |
Use of oral uridine as a substitute for parenteral uridine rescue of 5-fluorouracil therapy, with and without the uridine phosphorylase inhibitor 5-benzylacyclouridine.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Chromatography, High Pressure Liquid; Disease Models, Animal; Fluorouracil; Mammary Neoplasms, Experimental; Mice; Pentosyltransferases; Uracil; Uridine; Uridine Phosphorylase | 1989 |
19F NMR of 5-fluorouracil-substituted transfer RNA transcribed in vitro: resonance assignment of fluorouracil-guanine base pairs.
Topics: Anticodon; Cloning, Molecular; DNA Mutational Analysis; Fluorouracil; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Plasmids; RNA, Transfer, Amino Acid-Specific; RNA, Transfer, Val; Transcription, Genetic; Uracil | 1989 |
Nucleoside analogues. 9. Seco-nucleoside analogues of some 5-fluorouracil/nitrosourea molecular combinations having uracil as base: synthesis and anti-tumour activity.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Chemical Phenomena; Chemistry; Colonic Neoplasms; Fluorouracil; Lung Neoplasms; Mammary Neoplasms, Experimental; Nitrosourea Compounds; Nucleosides; Solubility; Uracil | 1989 |
[5-Fluorouracil, tegafur, and uracil concentrations in serum and tissue of the patients with hepatocellular carcinoma after UFT administration].
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Drug Combinations; Fluorouracil; Humans; Liver Neoplasms; Tegafur; Uracil | 1987 |
[Cancer chemotherapy of scirrhous type gastric cancer and evaluation of chemotherapeutic efficacy].
Topics: Adenocarcinoma, Scirrhous; Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Fluorouracil; Humans; Injections, Intravenous; Mitomycin; Mitomycins; Radiography; Stomach Neoplasms; Tegafur; Uracil | 1988 |
[Therapeutic treatment of Borrmann type 4 (scirrhous) gastric cancer-chemotherapy and histopathological studies].
Topics: Adenocarcinoma, Scirrhous; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Female; Fluorouracil; Gastric Mucosa; Humans; Male; Middle Aged; Mitomycin; Mitomycins; Stomach; Stomach Neoplasms; Tegafur; Uracil | 1988 |
[Effects of derivatives of Ara-C, 5-fluorouracil and nitrosourea against intracerebral implanted L1210 leukemia].
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Blood-Brain Barrier; Brain Neoplasms; Cytarabine; Fluorouracil; Leukemia L1210; Mice; Neoplasm Transplantation; Nimustine; Nitrosourea Compounds; Streptozocin; Tegafur; Uracil | 1987 |
[BOF-A1 and BOF-A2, new 5-FU degradation-inhibitory agents].
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Floxuridine; Fluorouracil; Liver; Mice; Pyridines; Pyrimidines; Rats; Sarcoma 180; Sarcoma, Experimental; Sarcoma, Yoshida; Tegafur; Uracil | 1987 |
[Comparative studies on the antitumor activity of the fluorinated pyrimidines 5'-DFUR, tegafur, UFT and FUra on various murine tumors].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Floxuridine; Fluorouracil; Leukemia P388; Liver Neoplasms, Experimental; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred Strains; Neoplasms, Experimental; Sarcoma 180; Tegafur; Uracil | 1988 |
Catabolism of 5-fluoro-2'-deoxyuridine by isolated rat intestinal epithelial cells.
Topics: Animals; Epithelium; Floxuridine; Fluorouracil; In Vitro Techniques; Intestinal Mucosa; Kinetics; Male; Pentosyltransferases; Pyrimidine Phosphorylases; Rats; Rats, Inbred Strains; Thymidine; Uracil | 1988 |
A sensitive non-radioactive assay for pyrimidine nucleoside phosphorylase using reversed-phase high performance liquid chromatography.
Topics: Cell Line, Transformed; Chromatography, High Pressure Liquid; Floxuridine; Fluorouracil; Humans; Kinetics; Pentosyltransferases; Pyrimidine Phosphorylases; Tumor Cells, Cultured; Uracil; Uridine | 1988 |
Familial pyrimidinemia and pyrimidinuria associated with severe fluorouracil toxicity.
Topics: Adult; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Female; Fluorouracil; Humans; Male; Purine-Pyrimidine Metabolism, Inborn Errors; Pyrimidines; Thymine; Uracil | 1985 |
[FT, 5-FU and uracil concentrations of the blood, bile and tissue of hepatoma with liver cirrhosis after oral administration of UFT].
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Bile; Carcinoma, Hepatocellular; Female; Fluorouracil; Humans; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged; Tegafur; Uracil | 1987 |
[UFT in the treatment of primary lung cancer--5-FU concentration in the tissue and side effects].
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Female; Fluorouracil; Humans; Lung Neoplasms; Male; Middle Aged; Tegafur; Uracil | 1987 |
[5-FU, FT-207 and uracil concentrations in the serum and tissues of patients with cervical cancer after UFT oral administration].
Topics: Administration, Oral; Adult; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Female; Fluorouracil; Humans; Kinetics; Middle Aged; Ovary; Tegafur; Uracil; Uterine Cervical Neoplasms | 1986 |
[5-FU concentration in blood and tissue of patients with primary lung cancer after oral administration of UFT].
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Female; Fluorouracil; Humans; Lung; Lung Neoplasms; Male; Middle Aged; Tegafur; Uracil | 1986 |
[The concentration in the tissue and antitumor effect of anticancer drug--assessment of breast cancer with UFT or FT-207].
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast; Breast Neoplasms; Drug Administration Schedule; Female; Fluorouracil; Humans; Tegafur; Uracil | 1986 |
[Clinical study of THP-adriamycin in patients with advanced gastric cancer].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Doxorubicin; Female; Fluorouracil; Humans; Male; Middle Aged; Stomach Neoplasms; Tegafur; Uracil | 1986 |
[5-FU concentration in the blood and tissue of patients with gastric and colorectal cancer after administration of UFT or tegafur].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Fluorouracil; Male; Rats; Rats, Inbred Strains; Rectal Neoplasms; Stomach Neoplasms; Tegafur; Uracil | 1986 |
[In vitro effects of 5-FU on gynecologic malignant tumor cell lines].
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Division; Cell Line; Cells, Cultured; Colony-Forming Units Assay; Female; Fluorouracil; Humans; Ovarian Neoplasms; Tegafur; Tumor Stem Cell Assay; Uracil; Uterine Cervical Neoplasms | 1986 |
[Serum and tissue concentrations of UFT in patients with lung cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Fluorouracil; Humans; Lung; Lung Neoplasms; Lymph Nodes; Lymphatic Metastasis; Tegafur; Uracil | 1986 |
[Chemosensitivity testing for 5-FU and 5-FU derivatives using subrenal capsule assay].
Topics: Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Colony-Forming Units Assay; Fluorouracil; Humans; Lung Neoplasms; Stomach Neoplasms; Tegafur; Tumor Stem Cell Assay; Uracil | 1987 |
[Concentration of 5-FU and tegafur in the ascites fluid in patients with peritonitis carcinomatosa after UFT oral administration].
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Ascitic Fluid; Fluorouracil; Gastrointestinal Neoplasms; Humans; Peritonitis; Tegafur; Uracil | 1987 |
Anticancer drug distribution in lymph and blood during adjuvant chemotherapy after surgery for gastric carcinoma. A study with a combined preparation of 1-(2-tetrahydrofuryl)-5-fluorouracil and uracil.
Topics: Combined Modality Therapy; Drug Combinations; Fluorouracil; Humans; Lymph; Male; Metabolic Clearance Rate; Middle Aged; Stomach Neoplasms; Tablets, Enteric-Coated; Tegafur; Uracil | 1987 |
[Studies on 5-FU concentration in serum and bladder tumor tissue after oral administration of UFT].
Topics: Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Female; Fluorouracil; Humans; Male; Middle Aged; Mucous Membrane; Tegafur; Uracil; Urinary Bladder; Urinary Bladder Neoplasms | 1986 |
[The effect of gastrectomy on serum 5-FU concentrations of patients administered UFT per os].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Fluorouracil; Gastrectomy; Humans; Male; Middle Aged; Postoperative Period; Stomach Neoplasms; Tegafur; Uracil | 1987 |
[Improved quality of life in a patient with Borrmann type 4 gastric cancer treated with combination chemotherapy].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Female; Fluorouracil; Humans; Methotrexate; Middle Aged; Mitomycin; Mitomycins; Picibanil; Prognosis; Quality of Life; Stomach Neoplasms; Tegafur; Uracil | 1987 |
[A study on UFT concentration in tissues and serum of patients with malignant gynecologic tumors following oral administration].
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Female; Fluorouracil; Genital Neoplasms, Female; Humans; Lymph Nodes; Ovary; Tegafur; Uracil; Uterus | 1987 |
Inhibitory effects of pyrimidine, barbituric acid and pyridine derivatives on 5-fluorouracil degradation in rat liver extracts.
Topics: Animals; Barbiturates; Chromatography, High Pressure Liquid; Dihydrouracil Dehydrogenase (NAD+); Fluorouracil; Kinetics; Liver; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Phosphorylation; Pyridines; Pyrimidines; Rats; Sarcoma 180; Thymine; Uracil | 1987 |
[5-FU concentration in tumor tissue and the antitumor effect in patients with gastric cancer after oral administration of UFT].
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Female; Fluorouracil; Humans; Male; Middle Aged; Stomach Neoplasms; Tegafur; Uracil | 1987 |
[Tegafur and 5-FU concentrations in cancerous and normal tissues in nude mice after oral administration of UFT].
Topics: Animals; Drug Combinations; Female; Fluorouracil; Kidney; Liver; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Tegafur; Time Factors; Tissue Distribution; Transplantation, Heterologous; Uracil; Urologic Neoplasms | 1987 |
[Antitumor effect of UFT on human ovarian cancer grafted to nude mice and 5-FU concentration in tumor and normal tissues].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Female; Fluorouracil; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Ovarian Neoplasms; Tegafur; Tissue Distribution; Uracil | 1988 |
[Antitumor effect of intermittent oral administration of UFT against human rectal cancer xenografted in nude mice].
Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Drug Administration Schedule; Fluorouracil; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Rectal Neoplasms; Tegafur; Uracil | 1988 |
[A case of recurrent sigmoid colon cancer successfully treated with 5-FU and UFT].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Female; Fluorouracil; Humans; Lymphatic Metastasis; Middle Aged; Sigmoid Neoplasms; Tegafur; Uracil | 1988 |
[Clinical study on the effect of chemotherapy in the treatment of pancreatic cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Female; Fluorouracil; Humans; Lymphatic Metastasis; Male; Middle Aged; Pancreatic Neoplasms; Prognosis; Tegafur; Uracil | 1988 |
Sensitivity test for 5-fluorouracil and its analogues, 1-(2-tetrahydrofuryl)-5-fluorouracil, uracil/1-(2-tetrahydrofuryl)-5-fluorouracil (4:1) and 1-hexylcarbamoyl-5-fluorouracil, using the subrenal capsule assay.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Drug Resistance; Fluorouracil; Gastrointestinal Neoplasms; Humans; Kidney; Male; Mice; Mice, Inbred C3H; Neoplasm Transplantation; Subrenal Capsule Assay; Tegafur; Uracil | 1988 |
[Inhibitory effect of UFT on postoperative lung metastasis of mammary adenocarcinoma in SHR rats].
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Drug Synergism; Female; Fluorouracil; Lentinan; Lung Neoplasms; Mammary Neoplasms, Experimental; Rats; Rats, Inbred SHR; Tegafur; Uracil | 1988 |
[Effects of OK-432 on UFT activation].
Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Biological Products; Fluorouracil; Humans; Liver Neoplasms, Experimental; Male; Middle Aged; Neoplasms; Picibanil; Rats; Rats, Inbred Strains; Tegafur; Uracil | 1988 |
[Experimental and clinical study of interactions between fluorinated pyrimidine derivatives and anticoagulants].
Topics: Animals; Anticoagulants; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Drug Synergism; Fluorouracil; Humans; Lung Neoplasms; Neoplasm Transplantation; Pyrimidines; Rats; Rats, Inbred Strains; Tegafur; Ticlopidine; Uracil; Warfarin | 1988 |
[The serum and tissue concentrations of tegafur, 5-fluorouracil and uracil in patients with gastric and colorectal cancers after oral administration of UFT].
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Fluorouracil; Humans; Rectal Neoplasms; Stomach Neoplasms; Tegafur; Uracil | 1988 |
[MQF-FT and MQF-UFT in gallbladder and bile duct cancer].
Topics: Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Bile Duct Neoplasms; Carbazilquinone; Drug Administration Schedule; Female; Fluorouracil; Gallbladder Neoplasms; Humans; Infusions, Intravenous; Male; Middle Aged; Mitomycin; Mitomycins; Picibanil; Tegafur; Uracil | 1988 |
[Blood and tumor levels of tegafur, 5-fluorouracil, and uracil].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Female; Fluorouracil; Humans; Male; Middle Aged; Stomach Neoplasms; Tegafur; Uracil | 1988 |
[Pre- and post-operative adjuvant chemotherapy of colorectal cancer. Part 1. Drug concentration in tissues following UFT administration].
Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Fluorouracil; Humans; Postoperative Period; Tegafur; Uracil | 1988 |
[Clinical studies of the treatment of bladder tumor and its effects--experience in 86 cases].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Combined Modality Therapy; Doxorubicin; Female; Fluorouracil; Humans; Male; Middle Aged; Mitomycin; Mitomycins; Picibanil; Prognosis; Tegafur; Uracil; Urinary Bladder Neoplasms | 1988 |
UFT is more antineoplastic against gastric carcinoma than 5-fluorouracil, 1-(2-tetrahydrofuryl)-5-fluorouracil and 1-hexylcarbamoyl-5-fluorouracil.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Fluorouracil; Male; Mice; Stomach Neoplasms; Subrenal Capsule Assay; Tegafur; Uracil | 1988 |
[Level of 5-fluorouracil in cancerous and normal tissues of nude mice bearing human endometrial carcinoma after administration of UFT coadministered with nicardipin].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Female; Fluorouracil; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Nicardipine; Tegafur; Transplantation, Heterologous; Uracil; Uterine Neoplasms | 1988 |
[Synchronization of tumor cells with 5-fluorouracil plus uracil and with vinblastine and irradiation of the synchronized cultures. A contribution to combined radio-chemotherapy].
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Division; Combined Modality Therapy; Fluorouracil; In Vitro Techniques; Mice; Neoplasm Transplantation; Sarcoma 180; Tumor Cells, Cultured; Uracil; Vinblastine | 1988 |
Absorption of 5-fluorouracil and related pyrimidines in rat small intestine.
Topics: Animals; Biological Transport, Active; Chromatography, High Pressure Liquid; Fluorouracil; Galactose; Intestinal Absorption; Intestinal Mucosa; Jejunum; Male; Perfusion; Rats; Rats, Inbred Strains; Thymine; Uracil; Water | 1987 |
Clinical and pharmacokinetic studies of prolonged administration of high-dose uridine intended for rescue from 5-FU toxicity.
Topics: Aged; Body Temperature; Drug Administration Schedule; Female; Fluorouracil; Humans; Infusions, Parenteral; Kinetics; Male; Middle Aged; Neoplasms; Uracil; Uridine | 1986 |
Effect of 5-diazouracil on the catabolism of circulating pyrimidines in rat liver and kidneys.
Topics: Animals; Bile; Cytosol; Fluorouracil; Intestinal Mucosa; Kidney; Liver; Metabolic Clearance Rate; Rats; Tissue Distribution; Uracil | 1986 |
In vitro degradation of pyrimidine bases: studies of rat liver dihydropyrimidine dehydrogenase.
Topics: Animals; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Kinetics; Liver; Oxidoreductases; Pyrimidines; Rats; Thymidine; Thymine; Uracil; Uridine | 1986 |
[Intra-arterial infusion chemotherapy using a subcutaneously implanted silicone reservoir--with reference to the chemotherapy protocol].
Topics: Abdominal Neoplasms; Aged; Antineoplastic Combined Chemotherapy Protocols; Catheterization; Cytarabine; Female; Fluorouracil; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Mitomycin; Mitomycins; Silicone Elastomers; Stomach Neoplasms; Tegafur; Uracil | 1985 |
[5-FU concentration in blood and tissue of patients with renal cell carcinoma after administration of UFT].
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Fluorouracil; Humans; Kidney Neoplasms; Tegafur; Uracil | 1985 |
[Preoperative treatment with UFT for patients with ovarian malignant tumors].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Female; Fluorouracil; Humans; Middle Aged; Ovarian Neoplasms; Ovary; Preoperative Care; Tegafur; Uracil | 1985 |
[Level of 5-FU in cancerous and normal tissues of nude mice after oral administration of tegafur coadministered with uracil (UFT)].
Topics: Adenocarcinoma; Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Drug Synergism; Female; Fluorouracil; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Tegafur; Uracil; Uterine Neoplasms | 1985 |
[5-FU concentration in the tissues (tumor and lymph node) of breast cancer patients given preoperative administration of UFT and FT].
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast; Breast Neoplasms; Female; Fluorouracil; Humans; Lymph Nodes; Preoperative Care; Tegafur; Uracil | 1985 |
Effects of a fluorinated pyrimidinedione anti-cancer drug, 5-fluoro-1-(tetrahydro-2-furanyl)-2,4-pyrimidinedione (FT), and related compounds on nigro-striatal dopaminergic neurons in the central nervous system.
Topics: 3,4-Dihydroxyphenylacetic Acid; alpha-Methyltyrosine; Animals; Antineoplastic Agents; Corpus Striatum; Dopamine; Fluorouracil; Haloperidol; Homovanillic Acid; Male; Methyltyrosines; Motor Activity; Neurons; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Substantia Nigra; Tegafur; Time Factors; Uracil | 1985 |
Enzymes of uracil catabolism in normal and neoplastic human tissues.
Topics: Amidohydrolases; beta-Alanine; Dihydrouracil Dehydrogenase (NAD+); Fluorouracil; Humans; Kinetics; Neoplasms; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Uracil | 1985 |
[A study on plasma and tissue 5-FU concentrations in patients with cervical cancer treated with UFT].
Topics: Antineoplastic Combined Chemotherapy Protocols; Female; Fluorouracil; Humans; Tegafur; Uracil; Uterine Cervical Neoplasms | 1985 |
[Level of 5-FU in uterine cervical cancer tissue after oral administration of UFT].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cervix Uteri; Female; Fluorouracil; Humans; Middle Aged; Tegafur; Uracil; Uterine Cervical Neoplasms | 1985 |
[5-FU concentration in tissues of gastric cancer patients with preoperative administration of UFT--especially in comparison with FT-207].
Topics: Antineoplastic Combined Chemotherapy Protocols; Fluorouracil; Humans; Levamisole; Stomach Neoplasms; Tegafur; Time Factors; Uracil | 1985 |
Effect of (E)-5-(2-bromovinyl)uracil on the catabolism and antitumor activity of 5-fluorouracil in rats and leukemic mice.
Topics: Animals; Bromouracil; Dihydrouracil Dehydrogenase (NADP); Drug Synergism; Fluorouracil; Leukemia P388; Leukemia, Experimental; Liver; Metabolic Clearance Rate; Mice; Oxidoreductases; Pyrimidines; Rats; Thymidine; Thymine; Uracil | 1986 |
Modulation of 5-fluorouracil catabolism in isolated rat hepatocytes with enhancement of 5-fluorouracil glucuronide formation.
Topics: Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Fluorouracil; In Vitro Techniques; Kinetics; Liver; Male; Pyrimidine Nucleosides; Rats; Rats, Inbred Strains; Thymine; Tritium; Uracil | 1985 |
Tissue-specific enhancement of uridine utilization and 5-fluorouracil therapy in mice by benzylacyclouridine.
Topics: Animals; Colonic Neoplasms; Female; Fluorouracil; Lethal Dose 50; Mice; Mice, Inbred C57BL; Uracil; Uridine | 1985 |
Effects of uridine and thymidine on the degradation of 5-fluorouracil, uracil, and thymine by rat liver dihydropyrimidine dehydrogenase.
Topics: Animals; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Kinetics; Liver; Oxidoreductases; Rats; Rats, Inbred Strains; Thymidine; Thymine; Uracil; Uridine | 1985 |
Highly sensitive determination of 5-fluorouracil in human plasma by capillary gas chromatography and negative ion chemical ionization mass spectrometry.
Topics: Alkylation; Bromouracil; Colonic Neoplasms; Fluorouracil; Gas Chromatography-Mass Spectrometry; Humans; Rectal Neoplasms; Time Factors; Uracil | 1985 |
Cross-induction of Escherichia coli lysogens by an ultraviolet irradiation product. I. The dispensability of concurrent macromolecular syntheses in the formation of a metabolically unstable inducer.
Topics: Chloramphenicol; Coliphages; Conjugation, Genetic; Dactinomycin; DNA, Bacterial; Edetic Acid; Escherichia coli; Fluorouracil; Lysogeny; Macromolecular Substances; Molecular Biology; Mutation; Puromycin; Radiation Genetics; RNA, Bacterial; Tryptophan; Ultraviolet Rays; Uracil; Uridine | 1967 |
[Detection of a moderate staphylococcal phage by means of antineoplastic agents].
Topics: Aminopterin; Antibiotics, Antineoplastic; Anticholesteremic Agents; Antimetabolites; Antineoplastic Agents; Chlorambucil; Colchicine; Cyclophosphamide; Dactinomycin; Drug Resistance, Microbial; Flavonoids; Fluorouracil; Lysogeny; Mechlorethamine; Melphalan; Mercaptopurine; Methotrexate; Mitomycins; Nitrogen Mustard Compounds; Olivomycins; Staphylococcus; Staphylococcus Phages; Thiotepa; Ultraviolet Rays; Uracil; Vinblastine; Vincristine | 1970 |
[Study of radioactive 5-fluoropyrimidine incorporation in Candida. Mechanism of resistance to 5-fluorocytosine].
Topics: Antifungal Agents; Candida; Carbon Radioisotopes; Cells, Cultured; Cytosine; Drug Resistance, Microbial; Flucytosine; Fluorouracil; Humans; Membrane Transport Proteins; Microbial Sensitivity Tests; Mutation; Pyrimidines; Uracil | 1974 |
GLC determination of fluorouracil.
Topics: Aniline Compounds; Bacillus subtilis; Biological Assay; Chromatography, Gas; Chromatography, Ion Exchange; Escherichia coli; Fluorouracil; Methods; Spectrophotometry, Ultraviolet; Thymine; Uracil | 1974 |
The roles of various biochemical effects produced by 5-fluorouracil in early growth inhibition of Bacillus cereus.
Topics: Bacillus cereus; Carbon Radioisotopes; Centrifugation, Density Gradient; Fluorouracil; Guanine; Ribosomes; RNA, Bacterial; Spectrophotometry, Ultraviolet; Thymidine; Uracil | 1974 |
[Effects of cytostatics and x-rays on nucleic acid metabolism of solid, malignant tumors in vitro].
Topics: Adenine; Animals; Antineoplastic Agents; Carbon Isotopes; Dactinomycin; Depression, Chemical; DNA, Neoplasm; Estriol; Fluorouracil; Formates; Glycine; Hypoxanthines; In Vitro Techniques; Leucine; Mercaptopurine; Methotrexate; Methylprednisolone; Neoplasm Proteins; Neoplasms, Experimental; Nucleosides; Orotic Acid; Radiation Effects; RNA, Neoplasm; Testosterone; Thymidine; Triaziquone; Uracil; Uridine | 1970 |
Metabolism of pyrimidines and pyrimidine nucleosides by Salmonella typhimurium.
Topics: Aminohydrolases; Cytidine; Cytosine; Deoxyuridine; Floxuridine; Flucytosine; Fluorouracil; Genetics, Microbial; Genotype; Mutation; Nucleosides; Nucleotidyltransferases; Pentosyltransferases; Phosphotransferases; Pyrimidines; Salmonella typhimurium; Thymidine; Uracil; Uracil Nucleotides; Uridine | 1972 |
Incorporation of idoxuridine analogs into corneal herpes simplex virus.
Topics: Animals; Autoradiography; Bromodeoxyuridine; Cornea; DNA, Viral; Epithelium; Floxuridine; Fluorouracil; Herpes Simplex; Idoxuridine; Keratitis, Dendritic; Ophthalmic Solutions; Rabbits; Thymidine; Tritium; Uracil | 1972 |
Complex formation of uracil, 2'-deoxyuridine and their 5-halogenated derivatives.
Topics: Bromodeoxyuridine; Bromouracil; Chemical Phenomena; Chemistry; Copper; Deoxyuridine; Drug Stability; Floxuridine; Fluorouracil; Idoxuridine; Mathematics; Nickel; Potentiometry; Silver; Uracil | 1973 |
Regeneration of invertase in Neurospora crassa.
Topics: Acetates; Acid Phosphatase; Biological Transport, Active; Carbon Isotopes; Culture Media; Cycloheximide; Dactinomycin; Enzyme Activation; Enzyme Repression; Fluorouracil; Glucose; Hydrogen-Ion Concentration; Leucine; Mannose; Mycotoxins; Neurospora; Neurospora crassa; Rifamycins; Spores, Fungal; Sucrase; Uracil | 1973 |
In vitro and in vivo virostatic properties of alkylated pyrimidines against DNA and RNA viruses.
Topics: Animals; Antiviral Agents; Deoxyuridine; DNA Viruses; Fluorouracil; Friend murine leukemia virus; Kidney; Mice; Pyrimidines; Rabbits; RNA Viruses; Simplexvirus; Spleen; Time Factors; Uracil; Vaccinia virus | 1969 |
A new and highly sensitive radiotracer assay for orotate phosphoribosyltransferase.
Topics: Animals; Carbon Isotopes; Cell Line; Chromatography, Thin Layer; Enzyme Activation; Fluorouracil; Hydrogen-Ion Concentration; Kinetics; Leukemia, Experimental; Magnesium; Methods; Mice; Microchemistry; Orotic Acid; Pentosephosphates; Pentosyltransferases; Phosphoric Acids; Ribose; Uracil | 1972 |
Electron spin resonance study of radicals produced in irradiated aqueous solutions of 5-halouracils.
Topics: Chlorine; Electron Spin Resonance Spectroscopy; Electrons; Fluorouracil; Free Radicals; Radiation Effects; Uracil | 1972 |
[Biochemical effect of certain radiation-sensitizing agents].
Topics: Bromouracil; Dactinomycin; DNA; Enzyme Induction; Fluorouracil; Humans; Protein Biosynthesis; Puromycin; Radiation-Sensitizing Agents; RNA, Messenger; Uracil | 1972 |
Inhibition of ribosomal ribonucleic acid maturation in Novikoff hepatoma cells by 5-fluorouracil and 5-fluorouridine.
Topics: Animals; Carbon Isotopes; Carcinoma, Hepatocellular; Cell Line; Electrophoresis; Fluorine; Fluorouracil; Kinetics; Liver Neoplasms; Methionine; Methylation; Neoplasms, Experimental; Rats; RNA, Ribosomal; Tritium; Uracil; Uridine | 1973 |
Influence of gene 55 on the regulation of synthesis of some early enzymes in bacteriophage T4-infected escherichia coli.
Topics: Cell-Free System; Coliphages; Crosses, Genetic; DNA Viruses; DNA, Bacterial; DNA, Viral; Escherichia coli; Fluorouracil; Genes; Genetic Complementation Test; Mutation; Phosphoric Monoester Hydrolases; Phosphotransferases; RNA, Bacterial; RNA, Messenger; Temperature; Time Factors; Transcription, Genetic; Tritium; Uracil; Viral Proteins | 1973 |
Pyrimidine metabolism in Pseudomonas acidovorans.
Topics: Adenosine; Alkanesulfonates; Amidohydrolases; Aspartate Carbamoyltransferase; Cell-Free System; Cytosine; Deoxyadenosines; Drug Resistance, Microbial; Enzyme Repression; Fluorouracil; Fumarate Hydratase; Mutagens; Mutation; Pentosyltransferases; Pseudomonas; Pyrimidines; Thymidylate Synthase; Uracil | 1974 |
Incorporation of precursors and inhibitors of nucleic acid synthesis into hepatomas and liver of the rat.
Topics: Amino Acids; Animals; Carbon Radioisotopes; Carcinoma, Hepatocellular; Cell Line; Fluorouracil; Injections, Intraperitoneal; Injections, Subcutaneous; Liver; Liver Neoplasms; Liver Regeneration; Male; Neoplasm Transplantation; Neoplasms, Experimental; Orotic Acid; Phosphates; Rats; RNA, Neoplasm; Schistosomicides; Thioxanthenes; Thymidine; Time Factors; Transplantation, Homologous; Tritium; Uracil; Uridine | 1974 |
A note on in vitro inhibition of thymine degradation by some pyrimidine analogues and related products.
Topics: Animals; Carbon Dioxide; Carbon Isotopes; Depression, Chemical; Fluorouracil; In Vitro Techniques; Liver; Pyrimidines; Swine; Thymine; Uracil | 1969 |
Dipole moments of 2,4-diketopyrimidines. II. Uracil, thymine and their derivatives.
Topics: Chemical Phenomena; Chemistry, Physical; Chlorine; Dioxanes; Ethyl Ethers; Evaluation Studies as Topic; Fluorouracil; Isomerism; Light; Mathematics; Nitro Compounds; Optics and Photonics; Pyrimidines; Pyrimidinones; Spectrophotometry, Infrared; Thymine; Uracil | 1974 |
Regulation of orotidylic acid pyrophosphorylase in Saccharomyces cerevisiae.
Topics: Amidohydrolases; Amino Acids; Aspartic Acid; Carbamates; Carboxy-Lyases; Cell-Free System; Culture Media; Enzyme Induction; Enzyme Repression; Fluorouracil; Genes; Genetic Complementation Test; Genetics, Microbial; Mutation; Orotic Acid; Oxidoreductases; Pentosyltransferases; Pyrimidines; Saccharomyces; Saccharomyces cerevisiae; Spectrophotometry; Transferases; Uracil; Uracil Nucleotides | 1972 |
Kinetics and mechanisms of drug action on microorganisms. XIV. The action of fluorouracil, other uracils and derived nucleosides on the microbial kinetics of Escherichia coli.
Topics: Bromodeoxyuridine; Bromouracil; Chlorine; Culture Media; Deoxyribonucleosides; Escherichia coli; Fluorouracil; Hydrogen-Ion Concentration; Kinetics; Nucleosides; Osmolar Concentration; Protein Binding; Time Factors; Uracil | 1972 |
Regulation of early mRNA synthesis in bacteriophage T4-infected bacteria: dependence on bacteriophage-specific protein synthesis.
Topics: Carbon Isotopes; Chloramphenicol; Chromatography, Thin Layer; Coliphages; DNA Viruses; DNA, Viral; Escherichia coli; Fluorouracil; Mutation; Ribonucleotides; RNA, Messenger; Temperature; Thymidine; Time Factors; Transcription, Genetic; Tritium; Uracil; Viral Proteins | 1973 |
Mutations of resistance to 5-fluorouracil in Escherichia coli K-12. I. Genetic mapping and properties of mutants of Escherichia coli K-12, resistant to low concentrations of 5-fluorouracil.
Topics: Carbon Radioisotopes; Chromosome Mapping; Chromosomes, Bacterial; Drug Resistance, Microbial; Escherichia coli; Extrachromosomal Inheritance; Fluorouracil; Mutation; Pentosyltransferases; Phenotype; Recombination, Genetic; Transduction, Genetic; Uracil | 1974 |
Thymine dimer excision in UV-irradiated and 5-fluorouracil-postincubated Escherichia coli.
Topics: Carbon Radioisotopes; Cell Count; Cell Survival; DNA Repair; DNA, Bacterial; Escherichia coli; Fluorouracil; Histidine; Mutation; Radiation Effects; Thymine; Ultraviolet Rays; Uracil | 1974 |
Use of fluorouracil-uracil combinations to study growth accompanied by insufficient deoxyribonucleic acid synthesis in Bacillus cereus.
Topics: Bacillus cereus; Carbon Isotopes; Cell Division; Cell Survival; Culture Media; DNA, Bacterial; Fluorouracil; Guanine; Micropore Filters; Spectrophotometry; Time Factors; Uracil | 1973 |
[Mechanism of action of ftorafur, a new antineoplastic agent].
Topics: Animals; Anti-Infective Agents; Antineoplastic Agents; Carbon Radioisotopes; Carcinoma, Ehrlich Tumor; Deoxyuridine; DNA, Neoplasm; Fluorouracil; Formates; Hot Temperature; In Vitro Techniques; Leukemia, Experimental; Mice; Neoplasm Transplantation; Orotic Acid; Pentosyltransferases; RNA, Neoplasm; Sarcoma 37; Spectrum Analysis; Uracil; Uridine | 1972 |
Isolation of the bromouracil-substituted light strand of mouse satellite DNA.
Topics: Animals; Bromouracil; Centrifugation, Density Gradient; Cesium; Chlorides; Chromatography; DNA; Fluorouracil; L Cells; Mice; Nucleotides; Phosphorus Isotopes; Tritium; Uracil | 1973 |
Influence of metal ions on systems of dimethylsulfoxide-uracil-derivatives: NMR investigations.
Topics: Barbiturates; Bromouracil; Cobalt; Copper; Deuterium; Dimethyl Sulfoxide; Fluorouracil; Ions; Iron; Ligands; Magnetic Resonance Spectroscopy; Metals; Nickel; Silver; Thiouracil; Uracil; Zinc | 1973 |
Repair replication induced by 3H incorporated into HeLa DNA.
Topics: Bromouracil; Centrifugation, Density Gradient; Culture Media; DNA Repair; DNA Replication; DNA, Neoplasm; Fluorouracil; HeLa Cells; Humans; In Vitro Techniques; Iodine Radioisotopes; Thymidine; Tritium; Uracil | 1974 |
Inhibition by 6-aminothymine of the degradation of nucleosides (5-iododeoxyuridine, thymidine) and pyrimidine bases (5-iodouracil, uracil and 5-fluorouracil) in vivo.
Topics: Amines; Animals; Antimetabolites; Bone Marrow; Chromatography; DNA; Fluorouracil; Idoxuridine; Intestinal Mucosa; Iodine Radioisotopes; Male; Mice; Nucleosides; Pentosyltransferases; Rabbits; Spleen; Thymidine; Thymine; Thymus Gland; Uracil | 1974 |
[Studies on the induction mechanisms in lysogenic bacteria. X. The effect of RNA-synthesis-inhibitors on the induction].
Topics: Azaguanine; Bacteriophage Typing; Coliphages; Dactinomycin; Escherichia coli; Flavins; Fluorouracil; Genetics, Microbial; RNA; Ultraviolet Rays; Uracil | 1966 |
Incorporation of 5-fluorouracil into the transfer RNA of Escherichia coli K12W6 and its effect on the methylation of uracil.
Topics: Carbon Isotopes; Chemical Phenomena; Chemistry; Deoxyribonucleases; Escherichia coli; Fluorouracil; Methionine; Methylation; Nucleotides; Pseudomonas; Pyrimidines; RNA, Bacterial; RNA, Transfer; Saccharomyces; Transferases; Uracil | 1969 |
Isolation of 5-fluorouracil-containing 5S ribonucleic acid from Escherichia coli.
Topics: Chromatography, DEAE-Cellulose; Chromatography, Gel; Escherichia coli; Fluorouracil; Methods; Nucleotides; Phenols; Photometry; RNA, Bacterial; RNA, Transfer; Sodium Chloride; Ultraviolet Rays; Uracil | 1970 |
Effect of 5-fluorouracil posttreatment on sensitivity to ultraviolet radiation and course of messenger RNA synthesis in Escherichia coli cells.
Topics: Agar; Amino Acids; Bacterial Proteins; Carbon Isotopes; Cell-Free System; Colorimetry; Culture Media; DNA Replication; DNA, Bacterial; Escherichia coli; Fluorouracil; Glucose; Leucine; Nucleosides; Phenylalanine; Radiation Effects; RNA, Bacterial; RNA, Messenger; Time Factors; Ultraviolet Rays; Uracil | 1971 |
Structural properties of 5-fluorouracil-containing transfer ribonucleic acids from Escherichia coli.
Topics: Buffers; Carbon Isotopes; Centrifugation, Density Gradient; Chemical Phenomena; Chemistry; Chromatography, Gel; Electrophoresis, Disc; Escherichia coli; Fluorouracil; Magnesium; Nucleic Acid Denaturation; Nucleosides; Pyrimidinones; Ribonucleases; Ribonucleosides; RNA, Bacterial; RNA, Transfer; Solubility; Spectrophotometry; Temperature; Ultraviolet Rays; Uracil | 1971 |
Properties of the DNA-delay mutants of bacteriophage T4.
Topics: Aniline Compounds; Carbon Isotopes; Centrifugation, Density Gradient; Cesium; Chlorides; Coliphages; DNA Replication; DNA, Bacterial; DNA, Viral; Escherichia coli; Fluorouracil; Genes, Recessive; Genetic Complementation Test; Genetics, Microbial; Leucine; Muramidase; Mutation; Nitrogen Isotopes; RNA, Messenger; Thymidine; Time Factors; Tritium; Uracil; Viral Proteins; Virus Replication | 1971 |
Dissociation of cellular functions in Bacillus cereus by 5-fluorouracil.
Topics: Adenine; Amino Acids; Bacillus cereus; Bacterial Proteins; Carbon Isotopes; Cell Wall; DNA, Bacterial; Fluorouracil; In Vitro Techniques; Penicillinase; RNA, Bacterial; Thymidine; Tritium; Uracil | 1966 |
Sensitivity of Nakahara-Fukuoka sarcoma to antitumor agents, especially to purine analogs.
Topics: Animals; Antineoplastic Agents; Busulfan; Cyclophosphamide; Female; Fluorouracil; Hydrocortisone; Mechlorethamine; Mercaptopurine; Methotrexate; Mice; Mitomycins; Purines; Sarcoma, Experimental; Thioguanine; Thiotepa; Uracil | 1969 |
[Effect of antineoplastic agents on the accumulation of collargol in cells of the reticuloendothelial system].
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Cytoplasm; Depression, Chemical; Fluorouracil; Liver; Lymph Nodes; Male; Melphalan; Mononuclear Phagocyte System; Nitrogen Mustard Compounds; Rats; Silver; Spleen; Thiotepa; Uracil | 1970 |
A convenient synthesis of 5-fluorouracil.
Topics: Fluorine; Fluorouracil; Methods; Uracil | 1972 |
The effect of bisulfite on the dehalogenation of 5-chloro-, 5-bromo-, and 5-iodouracil.
Topics: Bromouracil; Chemical Phenomena; Chemistry; Chlorine; Fluorouracil; Iodine; Kinetics; Magnetic Resonance Spectroscopy; Spectrophotometry; Sulfites; Sulfonic Acids; Ultraviolet Rays; Uracil | 1972 |
[Protonation of thymine, uracil and its 5-haloid-derivatives].
Topics: Bromouracil; Fluorouracil; Protons; Thymine; Uracil | 1972 |
The production of halide ion in the radiolysis of aqueous solutions of the 5-halouracils.
Topics: Bromouracil; Conductometry; Fluorouracil; Radiochemistry; Salts; Uracil | 1972 |
Pulse radiolysis studies of 5-halouracils in aqueous solutions.
Topics: Bromouracil; Chlorine; Fluorouracil; Kinetics; Radiochemistry; Spectrum Analysis; Ultraviolet Rays; Uracil | 1972 |
Role of catabolism in pyrimidine utilization for nucleic acid synthesis in vivo.
Topics: Animals; Azo Compounds; Dactinomycin; Depression, Chemical; DNA; DNA, Neoplasm; Fluorouracil; Intestine, Small; Iodine Isotopes; Leukemia, Experimental; Liver; Male; Nucleosides; Oxidoreductases; Pyrimidines; Rats; RNA; RNA, Neoplasm; Spleen; Thymidine; Thymine; Tritium; Uracil | 1972 |
Anomeric configuration of nucleosides by application of the internal Nuclear Overhauser Effect.
Topics: Adenine; Chemical Phenomena; Chemistry; Deoxyribonucleosides; Fluorouracil; Furans; Guanine; Hypoxanthines; Magnetic Resonance Spectroscopy; Mathematics; Molecular Conformation; Nucleic Acid Conformation; Nucleosides; Spectrum Analysis; Stereoisomerism; Uracil | 1972 |
18 F recoil labeling.
Topics: Deuterium; Fluorine; Fluorouracil; Isotope Labeling; Methods; Neon; Radioisotopes; Radionuclide Imaging; Uracil | 1972 |
In vivo inhibition of pyrimidine catabolism by 5-cyanouracil.
Topics: Animals; Carbon Dioxide; Fluorouracil; Liver; Metabolism; Pyrimidines; Rats; Thymine; Time Factors; Uracil | 1971 |
Inhibition of growth of treponemes by antimicrobial agents.
Topics: Animals; Anti-Bacterial Agents; Benzofurans; Coloring Agents; Drug Resistance, Microbial; Feces; Fluorouracil; Furazolidone; Humans; Methenamine; Mouth; Muramidase; Nalidixic Acid; Nitrofurazone; Rabbits; Sulfonamides; Sulfonic Acids; Swine; Thallium; Tolonium Chloride; Treponema; Uracil | 1971 |
Gas-liquid chromatography of some pyrimidine derivatives.
Topics: Bromine; Chemical Phenomena; Chemistry; Chlorine; Chromatography, Gas; Cytosine; Fluorouracil; Mathematics; Methods; Phenanthrenes; Pyrimidines; Silicon; Thymine; Triazines; Uracil | 1971 |
The lethality of streptomycin and the stimulation of RNA synthesis in the absence of protein synthesis.
Topics: Adenine; Arginine; Bacterial Proteins; Carbon Isotopes; Chloramphenicol; Drug Resistance, Microbial; Escherichia coli; Fluorouracil; Guanine; Kanamycin; Neomycin; Phosphates; RNA, Bacterial; Streptomycin; Sulfur Isotopes; Thymine; Uracil | 1966 |
Ribosome synthesis in Escherichia coli treated with 5-fluorouracil.
Topics: Bacterial Proteins; Dactinomycin; Escherichia coli; Fluorouracil; Ribosomes; RNA, Bacterial; Ultracentrifugation; Uracil | 1966 |
Inhibition of repressor formation in the lactose system of Escherichia coli by inhibitors of protein synthesis.
Topics: Antimetabolites; Chloramphenicol; DNA, Bacterial; Enzyme Repression; Escherichia coli; Fluorouracil; Galactosidases; Hot Temperature; Lactose; Mutation; Puromycin; RNA, Bacterial; Thymine; Uracil | 1966 |
Regulation of nucleoside triphosphate pools in Escherichia coli.
Topics: Adenine; Carbon Isotopes; Cytosine Nucleotides; Escherichia coli; Fluorouracil; Nucleotides; RNA, Bacterial; Uracil; Uridine | 1967 |
[The possibility of treating malignant tumors of the gastrointestinal tract with 5-fluoracil].
Topics: Aged; Antimetabolites; Female; Fluorouracil; Gastrointestinal Neoplasms; Humans; Male; Middle Aged; Uracil | 1969 |
[New possibilities in the treatment of epithelioma].
Topics: Animals; Fluorouracil; Humans; Precancerous Conditions; Rats; Skin Neoplasms; Thymine; Uracil | 1969 |
Metabolism of uracil and 5-fluorouracil in P388 murine leukemia cells.
Topics: Animals; Carbon Isotopes; Cell Line; Cell-Free System; Culture Techniques; Fluorouracil; Leukemia, Experimental; Nucleosides; Nucleotides; Phosphotransferases; Pyrimidines; RNA; Thymidine; Transferases; Uracil; Uridine | 1969 |
Genetic and physiological aspects of resistance to 5-fluoropyrimidines in Saccharomyces cerevisiae.
Topics: Aminohydrolases; Carbon Isotopes; Cell-Free System; Chromatography, Paper; Chromatography, Thin Layer; Chromosome Mapping; Cytosine; Drug Resistance, Microbial; Fluorine; Fluorouracil; Genetics, Microbial; Membrane Transport Proteins; Mutation; Phosphorus Isotopes; Phosphotransferases; Saccharomyces; Spectrophotometry; Transferases; Uracil; Uridine | 1970 |
A new method for treatment of carcinoma of the breast and colon with 5-fluorouracil.
Topics: Adult; Aged; Breast Neoplasms; Chemical Phenomena; Chemistry; Colonic Neoplasms; Female; Fluorouracil; Humans; Liver Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Thymine; Uracil | 1970 |
The effect of 5-fluorouracil on cells and regenerating protoplsts of Saccharoyces cerevisiae.
Topics: Agar; Cell Wall; Culture Media; Cytosine Nucleotides; DNA; Fluorouracil; Methods; Microbial Sensitivity Tests; Microscopy, Electron; Protein Biosynthesis; Proteins; Protoplasts; RNA; Saccharomyces; Time Factors; Uracil; Uridine | 1970 |
[tRNA's from yeast having incorporated 5-fluorouracil arising from in vivo deamination of 5-fluorocytosine].
Topics: Adenine; Amino Acids; Aminohydrolases; Chromatography, Paper; Cytosine; Deamination; Fluorine; Fluorouracil; Guanine; Mutation; RNA, Transfer; Saccharomyces; Spectrophotometry; Ultraviolet Rays; Uracil | 1970 |
[On uptake of 5-FU, 6-MP and methotrexate by ehrlich ascites tumor cells in vitro].
Topics: Adenine; Animals; Carcinoma, Ehrlich Tumor; Cell Membrane; Fluorouracil; In Vitro Techniques; Male; Mercaptopurine; Methotrexate; Mice; Sulfur Isotopes; Time Factors; Tritium; Uracil | 1970 |
[5'-desoxy-5'-fluorothymidine, a new inhibitor of the DNA synthesis].
Topics: Animals; Carcinoma, Ehrlich Tumor; Colorimetry; Depression, Chemical; DNA, Neoplasm; Fluorouracil; Mercaptopurine; Phosphates; Phosphorus Isotopes; RNA, Neoplasm; Spectrum Analysis; Thymidine; Triazines; Tritium; Uracil | 1968 |
Effects of 5-fluorouracil and 6-azauracil on the synthesis of ribonucleic acid and protein in Saccharomyces carlsbergensis.
Topics: Adenine; Antimetabolites; Carbon Isotopes; Centrifugation, Density Gradient; Depression, Chemical; DNA; Enzyme Induction; Fluorouracil; Glucosidases; Lysine; Molecular Weight; Phosphorus Isotopes; Protein Biosynthesis; Protoplasts; Ribosomes; RNA; Saccharomyces; Time Factors; Triazines; Uracil | 1968 |
The effect of 5-fluorouracil on the development of tail vertebrae of mice in organ culture.
Topics: Abnormalities, Drug-Induced; Animals; Culture Techniques; Fetus; Fluorouracil; Mice; Tail; Time Factors; Uracil | 1968 |
[A study of the incorporation of 5-fluorouracil into transfer and ribosomal ribonucleic acids of yeast].
Topics: Carbon Isotopes; Centrifugation, Density Gradient; Chemical Phenomena; Chemistry; Chromatography; Depression, Chemical; Fluorouracil; Polynucleotides; Pyrimidines; Ribosomes; RNA; RNA, Transfer; Saccharomyces; Spectrophotometry; Tritium; Uracil; Uridine | 1969 |
Initiation and suppression of apical hairs of Fucus embryos Fucus embryos.
Topics: Cell Differentiation; Eukaryota; Fluorouracil; Hair; In Vitro Techniques; Thymidine; Time Factors; Uracil | 1969 |
Antiglycolytic activities of 5-fluorouracil and related pyrimidines in mouse ascites carcinoma cells with special reference to inorganic phosphate and glucose.
Topics: Adenine; Animals; Arsenic; Carcinoma, Ehrlich Tumor; Carcinoma, Krebs 2; Deoxyuridine; Fluorouracil; Fructose; Glucose; Glutamine; Glycolysis; In Vitro Techniques; Manometry; Mice; Nucleosides; Phenols; Phosphates; Pyrimidines; Pyruvates; Respiration; Succinates; Uracil; Uridine | 1969 |
Stimulatory effects of inosine and deoxyinosine on the incorporation of uracil-2-14-C, 5-fluorouracil-2-14-C, and 5-bromouracil-2-14-C into nucleic acids by Ehrlich ascites tumor cells in vitro.
Topics: Animals; Carbon Isotopes; Carcinoma, Ehrlich Tumor; DNA, Neoplasm; Enzyme Precursors; Fluorouracil; Glucosyltransferases; In Vitro Techniques; Mice; Nucleosides; Ribose; RNA, Neoplasm; Uracil | 1969 |
Potentiation of the teratogenic effects of 5-fluorouracil by natural pyrimidines. I. Biological aspects.
Topics: Abnormalities, Drug-Induced; Animals; Carbon Isotopes; Carbon Tetrachloride Poisoning; Drug Synergism; Embryo, Mammalian; Female; Fluorouracil; Injections, Intraperitoneal; Kidney; Liver; Male; Maternal-Fetal Exchange; Pregnancy; Pyrimidines; Rats; Thymidine; Thymine; Uracil; Uridine | 1969 |
Potentiation of the teratogenic effects of 5-fluorouracil by natural pyrimidines. II. Biochemical aspects.
Topics: Animals; Carbon Isotopes; Depression, Chemical; DNA; Drug Synergism; Embryo, Mammalian; Extraembryonic Membranes; Female; Fluorouracil; Formates; Injections, Intraperitoneal; Ligases; Liver; Male; Phosphorus; Phosphorus Isotopes; Pregnancy; Rats; Thymidine; Thymidine Kinase; Thymine; Uracil | 1969 |
Uracil incorporation and photopigment synthesis in Rhodospirillum rubrum.
Topics: Antimycin A; Bacterial Proteins; Carbon Isotopes; Centrifugation, Density Gradient; Chloramphenicol; Chlorophyll; Chromatography, Ion Exchange; Cyanides; Darkness; Dinitrophenols; Fluorouracil; Hydrazines; Kinetics; Light; Mitomycins; Puromycin; Quinolines; Rhodospirillum; Ribosomes; RNA, Bacterial; RNA, Transfer; Time Factors; Tritium; Uracil | 1969 |
Immunobiological studies with the virostatics 5-ethyl-2'-deoxyuridine (EDU) and 1-allyl-3,5-diethyl-6-chlorouracil (ACIU).
Topics: Animals; Antibody Formation; Antiviral Agents; Deoxyuridine; Erythrocytes; Female; Fluorouracil; Hemagglutination; Hemolysin Proteins; Immunosuppressive Agents; Male; Mice; Sheep; Uracil | 1969 |
Effect of 5-fluorouracil on the growth of bacteriophage R17.
Topics: Coliphages; Fluorouracil; In Vitro Techniques; Kinetics; RNA, Viral; Uracil | 1965 |
The preparation of coliphage MS 2 containing 5-fluorouracil.
Topics: Centrifugation; Coliphages; Fluorouracil; RNA, Viral; Uracil | 1964 |
[Effects of 5-fluorouracil and 6-methylpurine on development of the egg of the sea urchin Paracentrotus lividus].
Topics: Animals; Antimetabolites; DNA; Echinodermata; Embryo, Nonmammalian; Female; Fluorouracil; In Vitro Techniques; Ovum; RNA; Thymine; Uracil | 1965 |
On the action of fluorouracil on leukemia cells.
Topics: Animals; Culture Techniques; DNA, Neoplasm; Fluorouracil; Leukemia L1210; Mice; Phosphorus Isotopes; Radiometry; RNA, Neoplasm; Uracil | 1966 |
Viruses grown in the presence of base analogs: specific alteration of susceptibility to inactivation by radiations, mutagens, and protodyes.
Topics: Arboviruses; Coloring Agents; Fluorouracil; Guanine; Hydroxylamines; In Vitro Techniques; Light; Methylene Blue; Newcastle disease virus; Nitrites; Nucleic Acids; Nucleosides; Photosensitivity Disorders; Purines; Sulfates; Thiouracil; Ultraviolet Rays; Uracil; Uridine; Virus Cultivation; Xanthine Oxidase | 1966 |
Morphogenesis in Trichoderma: suppression of photoinduction by 5-fluorouracil.
Topics: Carbon Isotopes; Cytosine Nucleotides; DNA; Fluorouracil; In Vitro Techniques; Mitosporic Fungi; Radiometry; RNA; Spores; Thymidine; Uracil; Uracil Nucleotides | 1966 |
Effects of ultraviolet radiation on RNA C-C glycosyls and other derivatives of uracil.
Topics: Chemical Phenomena; Chemistry, Physical; Fluorouracil; Nucleosides; Radiation Effects; RNA, Transfer; Spectrophotometry; Thymidine; Thymine; Ultraviolet Rays; Uracil; Uridine | 1966 |
Virus chemotherapy: its theoretical basis and possible relationship to the chemotherapy of cancer.
Topics: Adenoviridae; Antimetabolites; DNA, Viral; Fluorouracil; Herpesviridae; Oncogenic Viruses; Poxviridae; RNA, Viral; Uracil | 1966 |
[Antiblastic effect of various chemotherapeutic preparations on the cells of the Ehrlich ascites tumor].
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Busulfan; Carcinoma, Ehrlich Tumor; Fluorouracil; Mechlorethamine; Melphalan; Mercaptopurine; Mice; Nitrogen Mustard Compounds; Uracil | 1966 |
Chlorophyll formation in Euglena gracilis var. bacillaris: interference by analogues of purines, pyrimidines and amino acids.
Topics: Azaguanine; Chlorophyll; Citric Acid Cycle; Ethionine; Euglena; Fluorouracil; Mercaptopurine; Methionine; Purines; Thiouracil; Uracil | 1967 |
A direct synthesis of 1-beta-D-arabinofuranosyl-5-fluorocytosine.
Topics: Antineoplastic Agents; Arabinose; Cytosine; Fluorine; Fluorouracil; Nucleosides; Pyrimidines; Thiouracil; Uracil | 1967 |
Irreversible enzyme inhibitors. 99. Inhibitors of thymidine phosphorylase. 7. Further studies on hydrophobic bonding with hydrocarbon substituents on acidic uracils.
Topics: Chemical Phenomena; Chemistry; Fluorouracil; Glucosyltransferases; Uracil | 1967 |
Combination therapy of 3-methylcholanthrene-induced mammary carcinoma in rats: effect of chemotherapy, ovariectomy, and food restriction.
Topics: Animals; Estradiol; Fluorouracil; Lucanthone; Mammary Neoplasms, Experimental; Methylcholanthrene; Mitomycins; Progesterone; Rats; Starvation; Testosterone; Triazines; Uracil | 1967 |
Accumulation of pyrophosphate correlates with the increased level of nucleoside triphosphates in Escherichia coli.
Topics: Adenosine Triphosphate; Chromatography, High Pressure Liquid; Diphosphates; Escherichia coli; Fluorouracil; Hydroxyurea; Luminescent Measurements; Mercaptopurine; Mutation; Ribonucleotides; Species Specificity; Uracil | 1984 |
Mechanism for exclusion of 5-fluorouracil from DNA.
Topics: Deoxyuracil Nucleotides; DNA; Fluorodeoxyuridylate; Fluorouracil; In Vitro Techniques; N-Glycosyl Hydrolases; Pyrophosphatases; Uracil | 1980 |
Diphosphate concentration does not correlate with the level of inorganic diphosphatase in Escherichia coli.
Topics: Diphosphates; DNA Replication; Escherichia coli; Fluorouracil; Inorganic Pyrophosphatase; Kinetics; Mutation; Nalidixic Acid; Pyrophosphatases; Transcription, Genetic; Uracil | 1984 |
Incorporation and excision of 5-fluorouracil from deoxyribonucleic acid in Escherichia coli.
Topics: Deoxyuracil Nucleotides; DNA Glycosylases; DNA Repair; DNA, Bacterial; Escherichia coli; Fluorouracil; Mutation; N-Glycosyl Hydrolases; Pyrophosphatases; RNA, Bacterial; Uracil; Uracil-DNA Glycosidase | 1980 |
[Pharmacokinetics study of UFT in malignant brain tumor patients].
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Drug Combinations; Female; Fluorouracil; Glioma; Humans; Kinetics; Male; Middle Aged; Tegafur; Uracil | 1983 |
[Cancer of the maxillary antrum--a new multidisciplinary treatment containing neo-adjuvant chemotherapy].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cisplatin; Combined Modality Therapy; Drug Administration Schedule; Drug Combinations; Fluorouracil; Humans; Male; Maxillary Neoplasms; Middle Aged; Peplomycin; Tegafur; Uracil | 1984 |
Nitrogen metabolite repression of fluoropyrimidine resistance and pyrimidine uptake in Neurospora crassa.
Topics: Ammonia; Biological Transport; Drug Resistance, Microbial; Fluorouracil; Mutation; Neurospora; Neurospora crassa; Nitrogen; Pyrimidines; Temperature; Uracil; Uridine | 1982 |
Quantitative analysis of 5-fluorouracil and 5,6-dihydrofluorouracil in plasma by gas chromatography mass spectrometry.
Topics: Chromatography, High Pressure Liquid; Floxuridine; Fluorouracil; Gas Chromatography-Mass Spectrometry; Humans; Time Factors; Uracil | 1982 |
Nucleotide levels and incorporation of 5-fluorouracil and uracil into DNA of cells treated with 5-fluorodeoxyuridine.
Topics: Deoxyribonucleotides; DNA; Floxuridine; Fluorouracil; Humans; Lymphocytes; Uracil; Uracil Nucleotides | 1982 |
[Pharmacological and pharmacodynamic aspects of cancer chemotherapy, with special reference to 5-fluorouracil and its derivatives].
Topics: Antineoplastic Combined Chemotherapy Protocols; Drug Combinations; Floxuridine; Fluorouracil; Humans; Kinetics; Neoplasms; Tegafur; Uracil | 1982 |
[Development of fluoropyrimidine derivatives].
Topics: Animals; DNA Replication; Floxuridine; Fluorouracil; Mice; Phosphorylation; Pyrimidine Nucleotides; Rats; Sarcoma, Experimental; Tegafur; Uracil | 1984 |
[5-FU concentration in brain tumors after co-administration of FT and uracil].
Topics: Brain Neoplasms; Drug Therapy, Combination; Fluorouracil; Glioblastoma; Humans; Meningeal Neoplasms; Meningioma; Tegafur; Uracil | 1983 |
[Antineoplastic effect of UFT therapy (uracil-FT-207 combination therapy) on experimental pancreatic cancer transplanted in the pancreas and subcutaneous region].
Topics: Animals; Antineoplastic Agents; Carcinoma, Intraductal, Noninfiltrating; Cricetinae; Drug Therapy, Combination; Fluorouracil; Male; Mesocricetus; Neoplasm Transplantation; Neoplasms, Experimental; Pancreatic Neoplasms; Tegafur; Tissue Distribution; Transplantation, Homologous; Uracil | 1982 |
[Level of 5-FU in tumor tissues of the patients with head and neck malignant tumors after oral administration of UFT].
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Drug Combinations; Fluorouracil; Head and Neck Neoplasms; Humans; Lymph Nodes; Tegafur; Uracil | 1983 |
[UFT concentration in various tissues from cancer patients].
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capsules; Drug Combinations; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasms; Stomach Neoplasms; Tegafur; Tissue Distribution; Uracil | 1983 |
[Pharmacokinetics and a phase I study of tegafur-uracil enterogranules in cancer patients].
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Delayed-Action Preparations; Drug Combinations; Drug Evaluation; Female; Fluorouracil; Humans; Kinetics; Male; Middle Aged; Nausea; Neoplasms; Tegafur; Uracil | 1983 |
[Effective cases of advanced endometrial and recurrent ovarian cancers treated with oral administration of UFT].
Topics: Adenocarcinoma; Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Transitional Cell; Drug Combinations; Female; Fluorouracil; Humans; Lymphatic Metastasis; Middle Aged; Neoplasm Recurrence, Local; Ovarian Neoplasms; Tegafur; Uracil; Uterine Neoplasms | 1984 |
Effect of coadministration of uracil on the toxicity of tegafur.
Topics: Animals; beta-Alanine; Cats; Dogs; Female; Fluorouracil; Heart Diseases; Lethal Dose 50; Male; Mice; Nervous System Diseases; Rabbits; Rats; Rats, Inbred Strains; Species Specificity; Tegafur; Uracil | 1984 |
[Regulation of enzyme activities involved in pyrimidine synthesis and its application to cancer chemotherapy].
Topics: Administration, Oral; Animals; Deoxyuridine; Dihydrouracil Dehydrogenase (NAD+); DNA, Neoplasm; Drug Synergism; Fluorouracil; Neoplasms, Experimental; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Pentosyltransferases; Phosphorylation; Pyrimidines; Sarcoma, Yoshida; Tegafur; Thymidine; Thymine; Uracil; Uridine | 1984 |
[Studies on the mechanism of antitumor activity of 5-FU and its derivatives--relationship between the inhibition of tumor growth and the inhibition of thymidylate synthetase in vivo].
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Division; DNA, Neoplasm; Drug Combinations; Fluorouracil; Male; Methyltransferases; Mice; Sarcoma 180; Tegafur; Thymidylate Synthase; Uracil | 1984 |
[Chemotherapy of unresectable Borrmann type 4 gastric cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Doxorubicin; Drug Combinations; Fluorouracil; Humans; Mitomycin; Mitomycins; Nimustine; Nitrosourea Compounds; Picibanil; Proteoglycans; Stomach Neoplasms; Tegafur; Uracil | 1984 |
[Experimental chemotherapy of human gastrointestinal and breast cancers in nude mice and its correlation to clinical effect].
Topics: Adenocarcinoma; Adult; Aged; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Colonic Neoplasms; Cyclophosphamide; Drug Combinations; Female; Fluorouracil; Humans; Male; Mice; Mice, Nude; Middle Aged; Neoplasm Transplantation; Rectal Neoplasms; Stomach Neoplasms; Tegafur; Uracil | 1984 |
Enhanced accumulation of 5-fluorouracil in human tumors in athymic mice by co-administration of Ftorafur and uracil.
Topics: Animals; Colonic Neoplasms; Drug Therapy, Combination; Fluorouracil; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Tegafur; Time Factors; Transplantation, Heterologous; Uracil | 1984 |
[Pharmacokinetics of fluoropyrimidines].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Ehrlich Tumor; Fluorouracil; Humans; Infusions, Parenteral; Kinetics; Mice; Neoplasms; Rabbits; Tegafur; Uracil | 1984 |
[Comparative pharmacokinetic study between UFT and FT-207 suppo and phase II studies in gynecological malignancies].
Topics: Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Drug Evaluation; Female; Fluorouracil; Humans; Kinetics; Middle Aged; Tegafur; Uracil; Uterine Cervical Neoplasms; Uterine Neoplasms | 1984 |
[Genetic control of pathways of pyrimidine metabolism in Aspergillus nidulans. 1. Isolation and genetic analysis of 6-azauracil resistant mutants].
Topics: Aspergillus nidulans; Chromosome Mapping; Drug Resistance; Floxuridine; Fluorouracil; Genes, Dominant; Genes, Recessive; Mutation; Pyrimidines; Uracil | 1980 |
Phase I and pharmacokinetic studies of high-dose uridine intended for rescue from 5-fluorouracil toxicity.
Topics: Adult; Aged; Drug Evaluation; Female; Fluorouracil; Gastrointestinal Neoplasms; Humans; Infusions, Parenteral; Kinetics; Male; Middle Aged; Uracil; Uridine | 1984 |
Separation of 5-fluorouracil and uracil by ion-pair reversed-phase high-performance liquid chromatography on a column with porous polymeric packing.
Topics: Chromatography, High Pressure Liquid; Fluorouracil; Humans; Uracil; Uric Acid; Uridine | 1984 |
Effect of coadministration of thymine or thymidine on the antitumor activity of 1-(2-tetrahydrofuryl)-5-fluorouracil and 5-fluorouracil.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Biodegradation, Environmental; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Liver; Male; Mice; Phosphorylation; Rats; Sarcoma 180; Sarcoma, Yoshida; Tegafur; Thymidine; Thymidine Phosphorylase; Thymine; Uracil; Uridine; Uridine Phosphorylase | 1980 |
Clinical basis of chemotherapy for gastric cancer with uracil and 1-(2'-tetrahydrofuryl)-5-fluorouracil.
Topics: Female; Fluorouracil; Humans; In Vitro Techniques; Stomach Neoplasms; Tegafur; Time Factors; Uracil | 1980 |
High-pressure liquid chromatographic determination of ftorafur [1-(tetrahydro-2-furanyl)-5-fluorouracil] and GLC-mass spectrometric determination of 5-fluorouracil and uracil in biological materials after oral administration of uracil plus ftorafur.
Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Fluorouracil; Gas Chromatography-Mass Spectrometry; Male; Neoplasms, Experimental; Rats; Tegafur; Uracil | 1980 |
Determination of 5-fluorouracil and pyrimidine bases in plasma by gas chromatography-chemical ionization-mass fragmentography.
Topics: Cytosine; Fluorouracil; Gas Chromatography-Mass Spectrometry; Humans; Ions; Pyrimidines; Tegafur; Thymine; Uracil | 1980 |
Studies on the metabolism of 1-(2-tetrahydrofuryl)-5-fluorouracil and uracil co-administered orally to tumor-bearing rats.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Drug Combinations; Fluorouracil; Intestinal Absorption; Neoplasms, Experimental; Rats; Tegafur; Uracil | 1980 |
General pharmacological properties of UFT, a new type of anti-cancer agent consisting of 1-(2-tetrahydrofuryl)-5-fluorouracil (FT) and uracil. I: Pharmacological analysis of the combined effect of FT and uracil.
Topics: Analgesics; Animals; Anticonvulsants; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Behavior, Animal; Body Temperature; Brain Chemistry; Digestive System; Dogs; Drug Combinations; Electroencephalography; Female; Fluorouracil; Guinea Pigs; Hemodynamics; Male; Mice; Postural Balance; Rabbits; Rats; Respiration; Tegafur; Uracil | 1981 |
Resistance to fluorouracil in Candida utilis: effects on the uptake of pyrimidines and amino acids.
Topics: Amino Acids; Biological Transport; Candida; Drug Resistance, Microbial; Fluorouracil; Lysine; Nitrogen; Uracil | 1981 |
[Effects of UFT administered preoperatively in cases of gastric cancer (author's transl)].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Combinations; Female; Fluorouracil; Humans; Male; Middle Aged; Preoperative Care; Stomach Neoplasms; Tegafur; Uracil | 1981 |
The in vivo decrease of beta-alanine-2-oxoglutarate aminotransferase activity caused by 6-azauracil and 5-fluorouracil.
Topics: 4-Aminobutyrate Transaminase; Animals; beta-Alanine; Brain; Fluorouracil; gamma-Aminobutyric Acid; Liver; Male; Rats; Rats, Inbred Strains; Transaminases; Uracil | 1982 |
[Clinical trial of UFT in recurrent or advanced cancer].
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Drug Combinations; Drug Evaluation; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Rectal Neoplasms; Sigmoid Neoplasms; Tegafur; Uracil | 1982 |
[Two cases of carcinoid tumor of the stomach which responded to oral administration of UFT].
Topics: Administration, Oral; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoid Tumor; Drug Combinations; Female; Fluorouracil; Humans; Male; Middle Aged; Stomach Neoplasms; Tegafur; Uracil | 1982 |
[Clinical effect of UFT on bladder cancer].
Topics: Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Drug Combinations; Female; Fluorouracil; Humans; Male; Middle Aged; Tegafur; Uracil; Urinary Bladder Neoplasms | 1982 |
[Concentration of 5-FU level in the tissue and blood of the patients with breast cancer by preoperative administration of UFT].
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Drug Combinations; Female; Fluorouracil; Humans; Lymphatic Metastasis; Preoperative Care; Tegafur; Uracil | 1982 |
[Clinical experiences with UFD-1].
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Drug Combinations; Female; Fluorouracil; Humans; Kidney Neoplasms; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Neoplasms; Stomach Neoplasms; Tegafur; Uracil | 1982 |
A Salmonella typhimurium mutant dependent upon carbamyl aspartate for resistance to 5-fluorouracil is specifically affected in ubiquinone biosynthesis.
Topics: Carbamates; Drug Resistance, Microbial; Fluorouracil; Mutation; Salmonella typhimurium; Ubiquinone; Uracil | 1981 |
[Antitumor effect of UFT against malignant tumors of maxillary sinus--clinical and biochemical study].
Topics: Adenocarcinoma; Adult; Aged; Carcinoma, Squamous Cell; Drug Therapy, Combination; Female; Fluorouracil; Humans; Male; Maxillary Neoplasms; Melanoma; Middle Aged; Uracil | 1982 |
Facilitated transport of uracil and 5-fluorouracil, and permeation of orotic acid into cultured mammalian cells.
Topics: Animals; Biological Transport; Cell Membrane Permeability; Cells, Cultured; Cricetinae; Cricetulus; Female; Fluorouracil; HeLa Cells; Humans; Leukemia P388; Liver Neoplasms, Experimental; Mice; Orotic Acid; Ovary; Pyrimidines; Rats; Uracil | 1980 |
[Augmentation of chemotherapeutic efficaciousness of UFT by oral l-leucovorin--l-leucovorin factors enhancing cytotoxic activity of 5-fluorouracil].
Topics: Adenocarcinoma; Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Fluorouracil; Folic Acid; Humans; Leucovorin; Tegafur; Tumor Cells, Cultured; Uracil | 1995 |
[A case of gastric cancer responding well to MTX/5-FU (methotrexate/5-fluorouracil) and PMUE (CDDP, MMC, UFT, etoposide) therapies upon lymphnode recurrence].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Administration Schedule; Etoposide; Fluorouracil; Humans; Male; Methotrexate; Middle Aged; Mitomycin; Stomach Neoplasms; Tegafur; Uracil | 1995 |
Characterization of trimethoprim- and sulphisoxazole-resistant Chlamydia trachomatis.
Topics: Adenosine Triphosphate; Animals; Chlamydia trachomatis; DNA, Bacterial; Drug Resistance, Microbial; Fluorouracil; Guanosine Triphosphate; L Cells; Methotrexate; Mice; Microbial Sensitivity Tests; Mutation; Phenotype; RNA, Bacterial; Sulfisoxazole; Thymidine; Trimethoprim; Uracil; Zidovudine | 1994 |
Inhibitory effect of simultaneous intraportal administration of 5-fluorouracil, uracil and degradable starch microspheres on experimental hepatic micrometastasis, is of colon cancer.
Topics: Animals; Colorectal Neoplasms; Fluorouracil; Infusions, Intravenous; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Microspheres; Starch; Uracil | 1994 |
Observed resistance to pyrimidine analogs and sensitivity to uracil in Drosophila is attributed to deregulation of pyrimidine metabolism.
Topics: Alleles; Animals; Chromatography, High Pressure Liquid; Crosses, Genetic; Drosophila melanogaster; Female; Fluorouracil; Male; Mutagenesis; Pyrimidines; Species Specificity; Uracil; X Chromosome | 1994 |
[Blood levels of 5-FU and uracil on additional use of uracil in UFT therapy in gastrectomized patients].
Topics: Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Drug Administration Schedule; Female; Fluorouracil; Gastrectomy; Humans; Male; Stomach Neoplasms; Tegafur; Uracil | 1995 |
Incorporation of 5-fluorouracil into RNA by Mycobacterium avium complex strain LM1.
Topics: Biotransformation; Cytidine; Drug Resistance, Microbial; Fluorouracil; Mycobacterium avium Complex; RNA, Bacterial; Uracil; Uridine | 1993 |
Postoperative prophylactic lipiodolization reduces the intrahepatic recurrence of hepatocellular carcinoma.
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Chemotherapy, Adjuvant; Chemotherapy, Cancer, Regional Perfusion; Disease-Free Survival; Epirubicin; Feasibility Studies; Female; Fluorouracil; Hepatectomy; Humans; Iodized Oil; Liver Neoplasms; Male; Middle Aged; Neoplasm Recurrence, Local; Postoperative Care; Prospective Studies; Survival Rate; Tegafur; Uracil | 1995 |
The antitumor effect of hyperthermia combined with fluorouracil and its analogues.
Topics: Animals; Combined Modality Therapy; Fluorouracil; Hyperthermia, Induced; Male; Mice; Mice, Inbred BALB C; Sarcoma, Experimental; Tegafur; Uracil | 1995 |
[Case report of long-term survivor of advanced gastric cancer associated with peritoneal dissemination successfully treated with cancer chemotherapy].
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Female; Fluorouracil; Gastrectomy; Humans; Leucovorin; Methotrexate; Peritoneal Neoplasms; Prognosis; Stomach Neoplasms; Tegafur; Uracil | 1995 |
[A case of multiple liver metastasis from remnant gastric cancer responding to leucovorin.5-FU+UFT therapy].
Topics: Adenocarcinoma; Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Liver Neoplasms; Male; Neoplasm, Residual; Stomach Neoplasms; Tegafur; Uracil | 1995 |
Potentiation of 5-fluorouracil efficacy by the dihydrouracil dehydrogenase inhibitor, 5-benzyloxybenzyluracil.
Topics: Animals; Colonic Neoplasms; Dihydrouracil Dehydrogenase (NAD+); Drug Synergism; Female; Fluorouracil; Humans; Immune Tolerance; Lethal Dose 50; Mice; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Tumor Cells, Cultured; Uracil | 1994 |
Cloning and characterization of upp, a gene encoding uracil phosphoribosyltransferase from Lactococcus lactis.
Topics: Amino Acid Sequence; Base Sequence; Cloning, Molecular; Crossing Over, Genetic; Drug Resistance, Microbial; Fluorouracil; Gene Deletion; Gene Expression; Genes, Bacterial; Lactococcus lactis; Molecular Sequence Data; Pentosyltransferases; Promoter Regions, Genetic; Recombinant Fusion Proteins; Restriction Mapping; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Uracil | 1994 |
[Prevention of drug interactions and its countermeasure].
Topics: Animals; Arabinofuranosyluracil; Drug Interactions; Fluorouracil; Humans; Rats; Tegafur; Uracil | 1994 |
In vivo 19F NMR comparative study of 5-fluorouracil, 1-(2-tetrahydrofuryl)-5-fluorouracil (FT) and an FT-uracil coadministration system in mouse tumors.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Fluorine; Fluorouracil; Liver; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred ICR; Neoplasm Transplantation; Sarcoma 180; Tegafur; Uracil | 1994 |
5-Ethynyluracil (776C85): protection from 5-fluorouracil-induced neurotoxicity in dogs.
Topics: Animals; beta-Alanine; Central Nervous System Diseases; Dihydrouracil Dehydrogenase (NADP); Dogs; Dose-Response Relationship, Drug; Fluorouracil; Infusions, Intravenous; Male; Oxidoreductases; Uracil | 1994 |
Oral administration of BOF-A2 to rats with lung transplanted tumors results in increased 5-fluorouracil levels.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Disease Models, Animal; Drug Combinations; Drug Interactions; Fluorouracil; Lung; Lung Neoplasms; Male; Neoplasm Transplantation; Pyridines; Rats; Sarcoma, Yoshida; Tegafur; Transplantation, Heterologous; Uracil | 1994 |
cDNA cloning and chromosome mapping of human dihydropyrimidine dehydrogenase, an enzyme associated with 5-fluorouracil toxicity and congenital thymine uraciluria.
Topics: Amino Acid Sequence; Animals; Base Sequence; Chromosome Mapping; Chromosomes, Human, Pair 1; Cricetinae; Dihydrouracil Dehydrogenase (NADP); DNA, Complementary; Fluorouracil; Humans; Hybrid Cells; Metabolism, Inborn Errors; Mice; Molecular Sequence Data; Oxidoreductases; Recombinant Proteins; Swine; Thymine; Uracil | 1994 |
[Innate resistance to thymidylate synthase inhibition after 5-fluorouracil treatment--a rationale of combined use of cisplatin and its optimal administration dose].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Synergism; Fluorouracil; Male; Rats; Sarcoma, Yoshida; Tegafur; Thymidylate Synthase; Uracil | 1994 |
Combination of the chemotherapeutic agent 5-fluorouracil with an inhibitor of its catabolism results in increased micronucleus induction.
Topics: Animals; Binding Sites; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Kinetics; L Cells; Liver; Mice; Micronuclei, Chromosome-Defective; Oxidoreductases; Pyridines; Swine; Uracil | 1994 |
Differential effects of acyclothymidine, a potent pyrimidine nucleoside phosphorylase inhibitor, on the pharmacokinetics of doxifluridine in rabbits via oral administration.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Drug Interactions; Floxuridine; Fluorouracil; Male; Pentosyltransferases; Pyrimidine Phosphorylases; Rabbits; Uracil | 1993 |
5-Ethynyluracil (776C85): modulation of 5-fluorouracil efficacy and therapeutic index in rats bearing advanced colorectal carcinoma.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colorectal Neoplasms; Drug Synergism; Female; Fluorouracil; Leucovorin; Neoplasm Transplantation; Phosphonoacetic Acid; Rats; Rats, Inbred F344; Uracil | 1994 |
Effect of gastrectomy on the pharmacokinetics of tegafur, uracil, and 5-fluorouracil after oral administration of a 1:4 tegafur and uracil combination.
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Fluorouracil; Gastrectomy; Humans; Stomach Neoplasms; Tegafur; Time Factors; Uracil | 1994 |
3-Cyano-2,6-dihydroxypyridine (CNDP), a new potent inhibitor of dihydrouracil dehydrogenase.
Topics: Alanine; Animals; Antineoplastic Agents; Dihydrouracil Dehydrogenase (NAD+); Drug Synergism; Fluorouracil; Male; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Phosphorylation; Pyridines; Rats; Rats, Inbred Strains; Sarcoma, Yoshida; Tumor Cells, Cultured; Uracil | 1993 |
[The effect of induction chemotherapy with CBDCA, 5-FU and UFT in head and neck cancer].
Topics: Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Drug Administration Schedule; Fluorouracil; Head and Neck Neoplasms; Humans; Infusions, Intravenous; Male; Middle Aged; Tegafur; Uracil | 1994 |
[A comparative study on the serum and tissue 5-FU concentrations in patients with hepatocellular carcinoma after preoperative oral administration of UFT and 5'-DFUR].
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Chemotherapy, Adjuvant; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Liver; Liver Neoplasms; Male; Middle Aged; Tegafur; Uracil | 1994 |
New mechanism of action of the cancer chemotherapeutic agent 5-fluorouracil in human cells.
Topics: Binding, Competitive; Cell Count; Cells, Cultured; DNA; DNA Glycosylases; Fibroblasts; Floxuridine; Fluorouracil; Humans; Kinetics; N-Glycosyl Hydrolases; Uracil; Uracil-DNA Glycosidase | 1994 |
[Relationship between tissue concentrations of 5-FU and degeneration of tissues after UFT administration in patients with bladder tumor].
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Fluorouracil; Humans; Middle Aged; Tegafur; Uracil; Urinary Bladder Neoplasms | 1993 |
5-Ethynyluracil (776C85): a potent modulator of the pharmacokinetics and antitumor efficacy of 5-fluorouracil.
Topics: Administration, Oral; Animals; Biological Availability; Colonic Neoplasms; Dihydrouracil Dehydrogenase (NADP); Drug Synergism; Female; Fluorouracil; Male; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Neoplasms, Experimental; Oxidoreductases; Plasmacytoma; Rats; Therapeutic Equivalency; Uracil | 1993 |
Nucleosides and nucleotides. 122. 2'-C-cyano-2'-deoxy-1-beta-D-arabinofuranosylcytosine and its derivatives. A new class of nucleoside with a broad antitumor spectrum.
Topics: Adenine; Animals; Antineoplastic Agents; Cytarabine; Female; Fluorouracil; Humans; Leukemia L1210; Lymphoma, Large B-Cell, Diffuse; Mice; Molecular Structure; Neoplasm Transplantation; Structure-Activity Relationship; Thymine; Tumor Cells, Cultured; Uracil | 1993 |
Suppression of mammary tumors by oral administration of 1-(2-tetrahydrofuryl)-5-fluorouracil in combination with uracil in SHN virgin mice.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Female; Fluorouracil; Mammary Neoplasms, Experimental; Mice; Mice, Inbred Strains; Organ Size; Tegafur; Thymidine Kinase; Thymidylate Synthase; Uracil | 1993 |
The significance of preoperative chemotherapy for early gastric carcinoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Staging; Preoperative Care; Prognosis; Stomach Neoplasms; Tegafur; Uracil | 1993 |
[Clinical efficacy of cis-diamminedichloroplatinum [II] and 5-fluorouracil (UFT) in advanced cancer of the alimentary tract].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Colonic Neoplasms; Drug Administration Schedule; Esophageal Neoplasms; Female; Fluorouracil; Humans; Infusions, Intravenous; Male; Middle Aged; Stomach Neoplasms; Tegafur; Uracil | 1993 |
[Tissue and serum levels of 5-FU in the patients with head and neck malignant tumors--influence of a streptococcal preparation OK-432].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Immunotherapy; Lymphatic Metastasis; Male; Middle Aged; Picibanil; Tegafur; Uracil | 1993 |
[A comparison of 5-fluorouracil concentration of 5-fluorouracil drip infusion versus orally UFT in plasma of same patients].
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Female; Fluorouracil; Humans; Infusions, Intravenous; Lung Neoplasms; Male; Middle Aged; Tegafur; Uracil | 1993 |
Transport of 5-fluorouracil and uracil into human erythrocytes.
Topics: Adenine; Biological Transport; Erythrocytes; Fluorouracil; Humans; Hypoxanthine; Hypoxanthines; Kinetics; Nucleic Acids; Nucleosides; Papaverine; Tritium; Uracil | 1993 |
Effect of 5-fluorouracil and UFT on experimental liver metastasis model of colorectal cancer using mouse colon 26 cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Drug Combinations; Drug Screening Assays, Antitumor; Fluorouracil; Liver Neoplasms; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Tegafur; Uracil | 1993 |
[Pharmacodynamic study on the effectiveness of UFT against cancer of gastro-intestinal (GI) tract].
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Cell Count; Fluorouracil; Gastrointestinal Neoplasms; Humans; Nucleolus Organizer Region; Tegafur; Uracil | 1993 |
[The present status of chemotherapy for hepatocellular carcinoma].
Topics: Administration, Oral; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Cisplatin; Doxorubicin; Drug Delivery Systems; Fluorouracil; Humans; Infusion Pumps; Infusions, Intra-Arterial; Liver Neoplasms; Mitomycin; Survival Rate; Tegafur; Uracil | 1993 |
A pharmacodynamic and pharmacokinetic study of fluoropyrimidines in a nude mouse system and in postoperative patients with gastric cancer.
Topics: Adenocarcinoma; Administration, Oral; Animals; Colonic Neoplasms; Fluorouracil; Gastrectomy; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Stomach Neoplasms; Tegafur; Uracil | 1993 |
Effects of 5-fluorouracil and a combination of tegafur and uracil (UFT) on nucleotide metabolism in L1210 ascites tumor.
Topics: Animals; Deoxyribonucleotides; Fluorouracil; Injections, Intraperitoneal; Leukemia L1210; Male; Mice; Tegafur; Uracil | 1993 |
[Studies on tissue concentration of tegafur, 5-fluorouracil, uracil after UFT administration together with the study of microangiography of colorectal cancer].
Topics: Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Female; Fluorouracil; Gas Chromatography-Mass Spectrometry; Humans; Male; Middle Aged; Tegafur; Uracil | 1993 |
[A case of secondary leukemia induced by chemotherapy with a CDDP-based regimen for gastric cancer 5 years following radical resection].
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Female; Fluorouracil; Gastrectomy; Humans; Leukemia, Myeloid, Acute; Middle Aged; Mitomycin; Neoplasms, Second Primary; Proteoglycans; Stomach Neoplasms; Tegafur; Uracil | 1993 |
Identity of D-3-aminoisobutyrate-pyruvate aminotransferase with alanine-glyoxylate aminotransferase 2.
Topics: Alanine; Alanine Transaminase; Animals; beta-Alanine; Fluorouracil; Kinetics; Liver; Precipitin Tests; Rats; Transaminases; Uracil | 1993 |
[Antitumor activity of BOF-A2, a new 5-fluorouracil derivative, against human cancers xenografted in nude mice by intermittent administration].
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Colorectal Neoplasms; Drug Administration Schedule; Female; Fluorouracil; Humans; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Stomach Neoplasms; Tegafur; Uracil | 1993 |
Comparative studies on the metabolism of new fluorinated pyrimidine drugs in the liver by in vivo 19F magnetic resonance spectroscopic observation.
Topics: Alanine; Animals; Dihydrouracil Dehydrogenase (NAD+); Drug Interactions; Fluorouracil; Liver; Magnetic Resonance Spectroscopy; Male; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Pyridines; Rats; Rats, Wistar; Tegafur; Uracil | 1993 |
[Evaluation of long-term administration of oral anti-cancer agent].
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colonic Neoplasms; Drug Administration Schedule; Female; Fluorouracil; Humans; Male; Middle Aged; Mitomycin; Stomach Neoplasms; Tegafur; Uracil | 1993 |
[A case of advance colon cancer responding to sequential methotrexate and 5-fluorouracil therapy].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Drug Administration Schedule; Female; Fluorouracil; Humans; Liver Neoplasms; Methotrexate; Middle Aged; Remission Induction; Tegafur; Uracil | 1993 |
Dihydropyrimidine dehydrogenase activity in cancer patients.
Topics: Adult; Aged; Aged, 80 and over; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouracil; Head and Neck Neoplasms; Humans; Lymphocytes; Male; Middle Aged; Oxidoreductases; Pancreatic Neoplasms; Uracil | 1993 |
5-Ethynyluracil (776C85): effects on the antitumor activity and pharmacokinetics of tegafur, a prodrug of 5-fluorouracil.
Topics: Animals; Carcinoma; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Drug Synergism; Enzyme Inhibitors; Fluorouracil; Male; Neoplasm Transplantation; Oxidoreductases; Prodrugs; Rats; Tegafur; Uracil | 1995 |
[A case of common bile duct cancer responding to MMC leucovorin, 5-FU, and UFT combination chemotherapy and radiation].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Common Bile Duct Neoplasms; Female; Fluorouracil; Humans; Leucovorin; Mitomycin; Remission Induction; Tegafur; Uracil | 1996 |
[A case of advanced gastric cancer responding to chemotherapy and radiotherapy].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Combined Modality Therapy; Drug Administration Schedule; Ethanol; Fluorouracil; Gastrectomy; Humans; Injections, Intralesional; Liver Neoplasms; Male; Picibanil; Stomach Neoplasms; Tegafur; Uracil | 1996 |
Modulation of the pharmacokinetics of 5'-deoxy-5-fluorouridine and 5-fluorouracil in rats by oral co-administration of acyclothymidine.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Drug Interactions; Enzyme Inhibitors; Floxuridine; Fluorouracil; Intestines; Liver; Male; Pentosyltransferases; Pyrimidine Phosphorylases; Rats; Uracil | 1996 |
Modulation of [5-125I]iododeoxyuridine incorporation into tumour and normal tissue DNA by methotrexate and thymidylate synthase inhibitors.
Topics: Animals; Antimetabolites, Antineoplastic; Dihydrouracil Dehydrogenase (NAD+); DNA, Neoplasm; Female; Fluorouracil; Idoxuridine; Intestine, Small; Iodine Radioisotopes; Liver; Mammary Neoplasms, Experimental; Methotrexate; Mice; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Quinazolines; Thiophenes; Thymidylate Synthase; Uracil | 1996 |
Biochemical modulation: its pharmacological basis and clinical applications. Proceedings of a meeting. Singapore, October 19, 1995.
Topics: Antimetabolites, Antineoplastic; Drug Combinations; Fluorouracil; Humans; Prodrugs; Tegafur; Uracil | 1997 |
Mechanism-based improvement in the therapeutic selectivity of 5-FU prodrug alone and under conditions of metabolic modulation.
Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Administration Schedule; Drug Combinations; Drug Synergism; Fluorouracil; Leucovorin; Prodrugs; Rats; Tegafur; Uracil | 1997 |
Dihydropyrimidine dehydrogenase inactivation and 5-fluorouracil pharmacokinetics: allometric scaling of animal data, pharmacokinetics and toxicodynamics of 5-fluorouracil in humans.
Topics: Animals; Antimetabolites, Antineoplastic; Dihydrouracil Dehydrogenase (NADP); Dogs; Fluorouracil; Humans; Mice; Models, Chemical; Oxidoreductases; Rats; Uracil | 1997 |
[Immunotoxic effects of a new antineoplastic agent S-1 in mice--comparison with S-1, UFT and 5-FU].
Topics: Animals; Antibody Formation; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Blood Cell Count; Body Weight; Dose-Response Relationship, Drug; Drug Combinations; Fluorouracil; Immune System; Immune Tolerance; Immunologic Tests; Mice; Mice, Inbred BALB C; Organ Size; Oxonic Acid; Pyridines; Spleen; Tegafur; Thymus Gland; Uracil | 1996 |
Preventive effect of 1-(2-tetrahydrofuryl)-5-fluorouracil in combination with uracil on colonic carcinogenesis induced by 1,2-dimethylhydrazine in rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Cell Differentiation; Colorectal Neoplasms; Dimethylhydrazines; Fluorouracil; Male; Rats; Tegafur; Thymidine Kinase; Thymidylate Synthase; Uracil | 1997 |
Dual modulation of 5-fluorouracil cytotoxicity using folinic acid with a dihydropyrimidine dehydrogenase inhibitor.
Topics: Cell Survival; Dihydrouracil Dehydrogenase (NADP); Drug Interactions; Drug Synergism; Enzyme Inhibitors; Fluorouracil; Humans; Leucovorin; Oxidoreductases; Thymidylate Synthase; Tumor Cells, Cultured; Uracil | 1997 |
Rapid and sensitive high-performance liquid chromatographic analysis of halogenopyrimidines in plasma.
Topics: 5-Methylcytosine; Antimetabolites, Antineoplastic; Bromouracil; Chromatography, High Pressure Liquid; Cytosine; Flucytosine; Fluorouracil; Humans; Hydrogen-Ion Concentration; Osmolar Concentration; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Uracil | 1997 |
Future directions in the adjuvant treatment of colon cancer.
Topics: Antidotes; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colonic Neoplasms; Drug Combinations; Drug Therapy, Combination; Fluorouracil; Forecasting; Humans; Leucovorin; Tegafur; Uracil | 1997 |
A pharmacoeconomic comparison of UFT and 5-FU chemotherapy for colorectal cancer in South America.
Topics: Argentina; Brazil; Chemotherapy, Adjuvant; Colorectal Neoplasms; Costs and Cost Analysis; Drug Combinations; Drug Costs; Fluorouracil; Humans; Monte Carlo Method; South America; Tegafur; Uracil | 1997 |
5-Ethynyluracil (GW776): effects on the formation of the toxic catabolites of 5-fluorouracil, fluoroacetate and fluorohydroxypropionic acid in the isolated perfused rat liver model.
Topics: Animals; Bile; Enzyme Inhibitors; Fluoroacetates; Fluorouracil; In Vitro Techniques; Lactic Acid; Liver; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Wistar; Uracil | 1997 |
19F NMR monitoring of in vivo tumor metabolism after biochemical modulation of 5-fluorouracil by the uridine phosphorylase inhibitor 5-benzylacyclouridine.
Topics: Animals; Colonic Neoplasms; Enzyme Inhibitors; Fluorine Radioisotopes; Fluorouracil; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Uracil; Uridine Phosphorylase | 1997 |
A conserved aspartate of tRNA pseudouridine synthase is essential for activity and a probable nucleophilic catalyst.
Topics: Amino Acid Sequence; Aspartic Acid; Binding Sites; Catalysis; Cloning, Molecular; Conserved Sequence; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Escherichia coli; Fluorouracil; Genetic Vectors; Intramolecular Transferases; Molecular Sequence Data; Mutagenesis; Phosphorus Radioisotopes; RNA, Transfer, Asp; RNA, Transfer, Phe; Uracil | 1998 |
Benzylacyclouridine enhances 5-fluorouracil cytotoxicity against human prostate cancer cell lines.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Drug Interactions; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Fluorouracil; Humans; Male; Mice; Mice, Nude; Prostatic Neoplasms; Thymidylate Synthase; Tumor Cells, Cultured; Uracil; Uridine Phosphorylase | 1998 |
Improving 5-FU with a novel dihydropyrimidine dehydrogenase inactivator.
Topics: Antimetabolites, Antineoplastic; Clinical Trials as Topic; Dihydrouracil Dehydrogenase (NADP); Drug Synergism; Enzyme Inhibitors; Fluorouracil; Humans; Oxidoreductases; Uracil | 1998 |
Delayed hypersensitivity to 5-fluorouracil associated with reduced dihydropyrimidine dehydrogenase (DPD) activity.
Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Creatinine; Dihydrouracil Dehydrogenase (NADP); Drug Hypersensitivity; Fluorouracil; Gastrointestinal Neoplasms; Humans; Hypersensitivity, Delayed; Leukocytes; Lymphocytes; Male; Orotic Acid; Oxidoreductases; Pseudouridine; Uracil | 1998 |
Dihydropyrimidine dehydrogenase in livers from mouse and rat, and in human liver, colon tumors, and mucosa in relation to anabolism of 5-fluorouracil.
Topics: Animals; Biological Availability; Biotransformation; Colonic Neoplasms; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Humans; Intestinal Mucosa; Kinetics; Liver; Mice; Oxidoreductases; Rats; Species Specificity; Thymidine; Thymine; Uracil | 1998 |
[A case of gastric cancer with decreased dihydropyrimidine dehydrogenase activity].
Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouracil; Humans; Oxidoreductases; Pyrimidines; Stomach Neoplasms; Thymine; Uracil | 1998 |
Population and family studies of dihydropyrimidinuria: prevalence, inheritance mode, and risk of fluorouracil toxicity.
Topics: Adult; Amidohydrolases; Child; Child, Preschool; Female; Fluorouracil; Genes, Recessive; Homozygote; Humans; Infant; Japan; Male; Metabolism, Inborn Errors; Nuclear Family; Prevalence; Pyrimidines; Risk; Thymine; Uracil | 1998 |
Characterization of the human dihydropyrimidine dehydrogenase gene.
Topics: Alleles; Cloning, Molecular; Dihydrouracil Dehydrogenase (NADP); Exons; Fluorouracil; Gene Dosage; Humans; Introns; Leukocytes; Neoplasm Proteins; Oxidoreductases; Point Mutation; Polymerase Chain Reaction; Restriction Mapping; RNA Splicing; RNA, Messenger; Thymine; Uracil | 1998 |
Comparison of 5-fluorouracil pharmacokinetics in patients receiving continuous 5-fluorouracil infusion and oral uracil plus N1-(2'-tetrahydrofuryl)-5-fluorouracil.
Topics: Adenocarcinoma; Administration, Oral; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Drug Interactions; Female; Fluorouracil; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasms; Prodrugs; Tegafur; Uracil | 1998 |
[Complete remission of liver metastasis from rectal cancer following continuous oral administration of tegafur-uracil after intrahepatic arterial single injection of CDDP and 5-FU].
Topics: Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Combinations; Fluorouracil; Hepatic Artery; Humans; Injections, Intra-Arterial; Liver Neoplasms; Male; Rectal Neoplasms; Remission Induction; Tegafur; Uracil | 1998 |
[Combined chemotherapy with low-dose cisplatin, tegafur and uracil in a case with neck recurrence of laryngeal cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Combined Modality Therapy; Drug Administration Schedule; Fluorouracil; Humans; Laryngeal Neoplasms; Male; Middle Aged; Neoplasm Recurrence, Local; Tegafur; Uracil | 1998 |
Dihydropyrimidine dehydrogenase: a tumoral target for fluorouracil modulation.
Topics: Antimetabolites, Antineoplastic; Dihydrouracil Dehydrogenase (NADP); Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Inhibitors; Fluorouracil; Humans; Oxidoreductases; Tumor Cells, Cultured; Uracil | 1995 |
Possible prediction of adverse reactions to pyrimidine chemotherapy from urinary pyrimidine levels and a case of asymptomatic adult dihydropyrimidinuria.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Chromatography, High Pressure Liquid; Female; Fluorouracil; Humans; Male; Middle Aged; Uracil | 1996 |
Simultaneous determination of 5-fluorouracil and uracil by high-performance liquid chromatography using four serial columns.
Topics: Chromatography, High Pressure Liquid; Fluorouracil; Humans; Reproducibility of Results; Spectrophotometry, Ultraviolet; Uracil | 1998 |
In vivo effect of 5-ethynyluracil on 5-fluorouracil metabolism determined by 19F nuclear magnetic resonance spectroscopy.
Topics: Animals; Dihydrouracil Dehydrogenase (NADP); Enzyme Inhibitors; Fluorouracil; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Oxidoreductases; Uracil | 1999 |
Provision of positive and negative selections in retroviral vectors containing the cytosine deaminase gene.
Topics: Animals; Antimetabolites, Antineoplastic; Cytosine Deaminase; Fluorouracil; Gene Expression; Genetic Therapy; Genetic Vectors; Mice; Nucleoside Deaminases; Retroviridae; Transfection; Tumor Cells, Cultured; Uracil | 1998 |
Halogen anion formation in 5-halouracil films: X rays compared to subionization electrons.
Topics: Anions; Bromouracil; Chemical Phenomena; Chemistry, Physical; Electrons; Fluorouracil; Radiation-Sensitizing Agents; Uracil; X-Rays | 1999 |
[Preliminary evaluation of adjuvant chemotherapy against stage Ib or II gastric cancer].
Topics: Administration, Oral; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Female; Fluorouracil; Gastrectomy; Humans; Immunohistochemistry; Male; Middle Aged; Mitomycin; Retrospective Studies; Stomach Neoplasms; Survival Rate; Tegafur; Thymidine Phosphorylase; Tumor Suppressor Protein p53; Uracil | 1999 |
[A case of advanced gallbladder cancer responding to neoadjuvant intra-arterial chemotherapy].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Drug Administration Schedule; Drug Combinations; Duodenum; Epirubicin; Female; Fluorouracil; Gallbladder Neoplasms; Hepatectomy; Humans; Infusions, Intra-Arterial; Lymph Node Excision; Middle Aged; Neoadjuvant Therapy; Pancreatectomy; Tegafur; Uracil | 1999 |
UFT and eniluracil, oral variations of 5-FU, offer lower toxicity, phase II results show.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Breast Neoplasms; Clinical Trials, Phase II as Topic; Enzyme Inhibitors; Female; Fluorouracil; Humans; Prodrugs; Uracil | 1999 |
[Effective chemo-endocrine combination therapy for obstructive-jaundice caused by multiple liver metastasis of recurrent breast cancer--a case report].
Topics: Aged; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cholestasis; Cyclophosphamide; Doxorubicin; Drainage; Female; Floxuridine; Fluorouracil; Humans; Liver Neoplasms; Lung Neoplasms; Mastectomy, Radical; Medroxyprogesterone Acetate; Tamoxifen; Tegafur; Toremifene; Uracil | 1999 |
Life-threatening toxicity in a dihydropyrimidine dehydrogenase-deficient patient after treatment with topical 5-fluorouracil.
Topics: Aged; Antimetabolites, Antineoplastic; Blotting, Western; Carcinoma, Basal Cell; Diarrhea; Dihydrouracil Dehydrogenase (NADP); DNA Mutational Analysis; Fluorouracil; Gastrointestinal Hemorrhage; Humans; Inflammatory Bowel Diseases; Leukocytes, Mononuclear; Male; Oxidoreductases; Polymerase Chain Reaction; Sequence Deletion; Skin Neoplasms; Uracil | 1999 |
UFT and its metabolites inhibit the angiogenesis induced by murine renal cell carcinoma, as determined by a dorsal air sac assay in mice.
Topics: 4-Butyrolactone; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Cell Division; Diffusion Chambers, Culture; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Hydroxybutyrates; Kidney Neoplasms; Male; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Neovascularization, Pathologic; Tegafur; Tumor Cells, Cultured; Uracil | 1999 |
[Comparative study of histopathological effects of preoperative chemotherapy using UFT and in vitro MTT assay of colonoscopy specimens from patients with colorectal cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Colonoscopy; Colorectal Neoplasms; Drug Administration Schedule; Drug Screening Assays, Antitumor; Fluorouracil; Humans; Tegafur; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured; Uracil | 1999 |
5-ethyl-2'-deoxyuridine, a modulator of both antitumour action and pharmacokinetics of 5-fluorouracil.
Topics: Animals; Antimetabolites, Antineoplastic; Area Under Curve; Colonic Neoplasms; Deoxyuridine; Dose-Response Relationship, Drug; Drug Synergism; Fluorodeoxyuridylate; Fluorouracil; Male; Metabolic Clearance Rate; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Time Factors; Treatment Outcome; Uracil; Uridine | 1999 |
[Consideration of cancer home chemotherapy with cooperation between hospital and clinic].
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cooperative Behavior; Drug Administration Schedule; Fluorouracil; Home Care Services, Hospital-Based; Humans; Neoplasms; Quality of Life; Tegafur; Uracil | 1999 |
[PMC (pharmacokinetic modulating chemotherapy) for advanced gastric cancer].
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Drug Administration Schedule; Female; Fluorouracil; Gastrectomy; Humans; Infusions, Intravenous; Male; Middle Aged; Stomach Neoplasms; Survival Rate; Tegafur; Uracil | 1999 |
[Effective and low toxicity chemoradiotherapy for distant metastatic esophageal cancer].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Drug Administration Schedule; Esophageal Neoplasms; Fluorouracil; Humans; Infusions, Intravenous; Lung Neoplasms; Lymphatic Metastasis; Male; Tegafur; Uracil | 1999 |
[Long-term complete response in a case of unresectable rectal cancer following chemoradiation].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Drug Administration Schedule; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Radiotherapy Dosage; Rectal Neoplasms; Remission Induction; Tegafur; Uracil | 2000 |
[A case of stage IVb (H2P0N4T4) gastric cancer successfully treated with neoadjuvant chemotherapy (PMFE therapy)].
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Etoposide; Fluorouracil; Gastrectomy; Humans; Male; Mitomycin; Neoadjuvant Therapy; Remission Induction; Stomach Neoplasms; Tegafur; Uracil | 2000 |
[Improved QOL with cancer chemotherapy in two patients with breast cancer suffering form carcinomatous pleurisy and carcinomatous peritonitis].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Female; Fluorouracil; Humans; Medroxyprogesterone Acetate; Middle Aged; Peritonitis; Pleurisy; Quality of Life; Tegafur; Uracil | 2000 |
[A case of AFP-producing gastric cancer after curative operation effectively treated with chemotherapies including hepatic arterial infusion therapy].
Topics: Adenocarcinoma; alpha-Fetoproteins; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Combined Modality Therapy; Doxorubicin; Female; Fluorouracil; Hepatic Artery; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Middle Aged; Stomach Neoplasms; Tegafur; Uracil | 2000 |
[Comparison of pharmacokinetics of 5-FU and alpha-fluoro-beta-alanine, a metabolite of 5-FU, in plasma after administration of UFT, tegafur, 5-FU or doxifluridine to rats].
Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; beta-Alanine; Floxuridine; Fluorouracil; Male; Rats; Rats, Sprague-Dawley; Tegafur; Uracil | 2000 |
[Antitumor activity of 1-hexylcarbamoyluracil which is carmofur substituted fluorine for hydrogen].
Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; Female; Fluorouracil; Mice; Mice, Inbred BALB C; Stomach Neoplasms; Tumor Cells, Cultured; Uracil | 2000 |
Therapeutic effect of 1 M tegafur-0.4 M 5-chloro-2, 4-dihydroxypridine-1 M potassium oxonate (S-1) on head and neck squamous carcinoma cells.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; Drug Combinations; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Mice, SCID; Neoplasm Transplantation; Oxonic Acid; Pyridines; Survival Rate; Tegafur; Transplantation, Heterologous; Tumor Cells, Cultured; Uracil | 2000 |
Tissue distribution and biotransformation of potassium oxonate after oral administration of a novel antitumor agent (drug combination of tegafur, 5-chloro-2,4-dihydroxypyridine, and potassium oxonate) to rats.
Topics: Administration, Oral; Allopurinol; Animals; Antimetabolites, Antineoplastic; Area Under Curve; Biotransformation; Carbon Radioisotopes; Chlorpromazine; Drug Combinations; Drugs, Chinese Herbal; Fluorouracil; Glycyrrhiza; Intestine, Small; Male; Microsomes, Liver; Oxonic Acid; Paeonia; Pyridines; Rats; Rats, Inbred Strains; Sarcoma, Yoshida; Tegafur; Tissue Distribution; Triazines; Uracil; Xanthine Oxidase | 2000 |
[5-FU concentration in the serum and the tumor tissue after administration of UFT 200 mg/day to patients over 80 years of age with oral cancer].
Topics: Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Female; Fluorouracil; Humans; Male; Mouth Neoplasms; Tegafur; Uracil | 2000 |
[A case of advanced rectal cancer with unresectable liver metastasis for which chemotherapy was markedly effective].
Topics: Adenocarcinoma; Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Female; Fluorouracil; Humans; Infusion Pumps, Implantable; Liver Neoplasms; Middle Aged; Mitomycin; Rectal Neoplasms; Remission Induction; Tegafur; Uracil | 2000 |
[A case report of unresectable colon cancer that disappeared following pharmacokinetic modulation chemotherapy (PMC)].
Topics: Administration, Oral; Adult; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Drug Administration Schedule; Fluorouracil; Humans; Infusions, Intravenous; Liver Neoplasms; Male; Peritoneal Neoplasms; Prognosis; Quality of Life; Remission Induction; Tegafur; Uracil | 2000 |
Postsurgical sequential methotrexate, fluorouracil, and leucovorin for stages 3 and 4 gastric carcinoma: A preliminary study.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Drug Administration Schedule; Female; Fluorouracil; Gastrectomy; Humans; Leucovorin; Lymphatic Metastasis; Male; Methotrexate; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Stomach Neoplasms; Survival Rate; Tegafur; Uracil | 2000 |
Blocking catabolism with eniluracil enhances PET studies of 5-[18F]fluorouracil pharmacokinetics.
Topics: Animals; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Enzyme Inhibitors; Female; Fluorine Radioisotopes; Fluorouracil; Radiopharmaceuticals; Rats; Rats, Inbred F344; Tomography, Emission-Computed; Uracil | 2000 |
Enzyme inhibition as an aid to simplify pharmacokinetic measurements?
Topics: Animals; Antimetabolites, Antineoplastic; Enzyme Inhibitors; Fluorine Radioisotopes; Fluorouracil; Radiopharmaceuticals; Rats; Uracil | 2000 |
Uracil salvage pathway in PC12 cells.
Topics: Animals; Carbon Radioisotopes; Cell Extracts; Fluorouracil; Models, Chemical; PC12 Cells; Phosphoribosyl Pyrophosphate; Purines; Pyrimidines; Rats; Uracil | 2001 |
[A successful case of preoperative intermittent hepatic arterial infusion of high-dose 5-FU and pharmacokinetic modulating chemotherapy against unresectable liver metastasis of colon cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Drug Administration Schedule; Fluorouracil; Hepatectomy; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Sigmoid Neoplasms; Tegafur; Uracil | 2000 |
A novel weekday-on/weekend-off UFT schedule.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Fluorouracil; Humans; Male; Rats; Sarcoma; Survival Analysis; Tegafur; Uracil | 2000 |
[Oral chemotherapeutic agents: the roles in cancer chemotherapy].
Topics: Administration, Oral; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Drug Combinations; Fluorouracil; Humans; Neoplasms; Oxonic Acid; Pyridines; Tegafur; Uracil | 1999 |
[A case of pulmonary metastases of breast cancer responding remarkably to combined chemotherapy with 5-fluorouracil and low-dose cisplatin].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cisplatin; Drug Administration Schedule; Female; Fluorouracil; Humans; Lung Neoplasms; Mastectomy; Middle Aged; Tegafur; Uracil | 2000 |
[Outcomes of home anti-cancer chemotherapy--estimation of hepatic arterial infusion chemotherapy for patients with multiple liver metastases].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Colonic Neoplasms; Fluorouracil; Hepatic Artery; Home Care Services; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Mitomycin; Quality of Life; Stomach Neoplasms; Survival Rate; Tegafur; Treatment Outcome; Uracil | 2000 |
[Long survival in a case of unresectable hepatic metastasis from rectal carcinoma treated with second-look hepatectomy plus pharmacokinetic modulating chemotherapy (PMC)].
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Drug Administration Schedule; Female; Fluorouracil; Hepatectomy; Hepatic Artery; Humans; Infusion Pumps; Infusions, Intra-Arterial; Liver Neoplasms; Mitomycin; Rectal Neoplasms; Reoperation; Tegafur; Uracil | 2001 |
Dual antitumor effects of 5-fluorouracil on the cell cycle in colorectal carcinoma cells: a novel target mechanism concept for pharmacokinetic modulating chemotherapy.
Topics: Adenocarcinoma; Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Cycle; Cell Cycle Proteins; Cell Division; Colorectal Neoplasms; DNA, Neoplasm; Dose-Response Relationship, Drug; Flow Cytometry; Fluorouracil; Humans; Infusions, Intravenous; Tegafur; Tumor Cells, Cultured; Uracil | 2001 |
[A case of gastric cancer with liver metastases successfully treated with combination therapy of systemic and hepatic arterial infusion chemotherapy].
Topics: Administration, Oral; Aged; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Doxorubicin; Drug Combinations; Fluorouracil; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Liver Neoplasms; Male; Mitomycin; Stomach Neoplasms; Tegafur; Uracil | 2001 |
[A case of advanced gastric cancer complicated with liver metastases responding remarkably to combined chemotherapy with 5-fluorouracil and low-dose cisplatin, with UFT and low-dose cisplatin for maintenance on an outpatient basis].
Topics: Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Fluorouracil; Humans; Liver Neoplasms; Male; Stomach Neoplasms; Tegafur; Uracil | 2001 |
Rapid detection of a common dihydropyrimidine dehydrogenase mutation associated with 5-fluorouracil toxicity and congenital thymine uraciluria using fluorogenic hybridization probes.
Topics: Alleles; Antimetabolites; Dihydrouracil Dehydrogenase (NADP); Fluorescent Dyes; Fluorouracil; Genotype; Humans; Molecular Sequence Data; Mutation; Nucleic Acid Hybridization; Oxidoreductases; Polymorphism, Genetic; Sequence Analysis, DNA; Temperature; Thymine; Uracil | 2001 |
Lethal outcome of a patient with a complete dihydropyrimidine dehydrogenase (DPD) deficiency after administration of 5-fluorouracil: frequency of the common IVS14+1G>A mutation causing DPD deficiency.
Topics: Adult; Antimetabolites, Antineoplastic; Dihydrouracil Dehydrogenase (NADP); Exons; Fatal Outcome; Female; Fibroblasts; Fluorouracil; Gene Frequency; Humans; Leukocytes, Mononuclear; Mutation; Oxidoreductases; Polymorphism, Restriction Fragment Length; Thymine; Uracil | 2001 |
[Relationship between the anti-metastatic effect of UFT and in vitro chemosensitivity to 5-FU in metastatic tumors from orthotopic implanted colon cancer in nude rats].
Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; Drug Combinations; Drug Screening Assays, Antitumor; Fluorouracil; Humans; Liver Neoplasms; Lung Neoplasms; Lymphatic Metastasis; Male; Neoplasm Transplantation; Rats; Rats, Nude; Tegafur; Transplantation, Heterologous; Uracil | 2001 |
A pharmacological study of the weekday-on/weekend-off oral UFT schedule in colorectal cancer patients.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Colorectal Neoplasms; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Male; Middle Aged; Tegafur; Uracil | 2001 |
Extraction of 5-fluorouracil by tumor and liver: a noninvasive positron emission tomography study of patients with gastrointestinal cancer.
Topics: Antimetabolites, Antineoplastic; Dihydrouracil Dehydrogenase (NADP); Enzyme Inhibitors; Fluorine Radioisotopes; Fluorouracil; Gastrointestinal Neoplasms; Humans; Liver; Liver Neoplasms; Models, Biological; Oxidoreductases; Pancreatic Neoplasms; Tomography, Emission-Computed; Uracil | 2001 |
Peripheral neuropathy associated with weekly oral 5-fluorouracil, leucovorin and eniluracil.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain; Colonic Neoplasms; Dihydrouracil Dehydrogenase (NADP); Electromyography; Female; Fluorouracil; Humans; Leucovorin; Magnetic Resonance Imaging; Male; Middle Aged; Oxidoreductases; Peripheral Nervous System Diseases; Time Factors; Uracil | 2001 |
[Efficacy of intraperitoneal chemotherapy for peritoneal recurrence of gastric carcinoma].
Topics: Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Gastrectomy; Humans; Infusion Pumps, Implantable; Infusions, Parenteral; Mitomycin; Peritoneal Neoplasms; Stomach Neoplasms; Tegafur; Uracil | 2001 |
Plasma, intestine and tumor levels of 5-fluorouracil in mice bearing L1210 ascites tumor following oral administration of 5-fluorouracil, UFT (mixed compound of tegafur and uracil), carmofur and 5'-deoxy-5-fluorouridine.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Drug Combinations; Floxuridine; Fluorouracil; Intestinal Mucosa; Leukemia L1210; Male; Mice; Tegafur; Uracil | 2001 |
Oral fluoropyrimidines: are they the equivalent of parenteral infusional 5-fluorouracil?
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Deoxycytidine; Fluorouracil; Humans; Infusions, Intravenous; Tegafur; Uracil | 2001 |
[A case of spindle cell type hepatocellular carcinoma responding to hepatic intra-arterial infusion chemotherapy].
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Middle Aged; Tegafur; Uracil | 2002 |
Pathways for alpha-D-ribose utilization for nucleobase salvage and 5-fluorouracil activation in rat brain.
Topics: Adenine; Animals; Antimetabolites; Brain; Fluorouracil; In Vitro Techniques; Male; Phosphoribosyl Pyrophosphate; Purine Nucleotides; Pyrimidine Nucleotides; Rats; Rats, Sprague-Dawley; Ribose; Uracil | 2002 |
An evolving role for oral fluoropyrimidine drugs.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Deoxycytidine; Drug Therapy; Enzyme Inhibitors; Female; Fluorouracil; Humans; Pyrimidines; Uracil | 2002 |
[Dormant chemotherapy by low-dose FP and low-dose UFT-E in recurrent gastric cancer with long-term survival--a case report].
Topics: Adenocarcinoma, Papillary; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Administration Schedule; Drug Combinations; Fluorouracil; Humans; Lymph Node Excision; Lymphatic Metastasis; Male; Middle Aged; Stomach Neoplasms; Survivors; Tegafur; Uracil | 2002 |
A comparative analysis of translated dihydropyrimidine dehydrogenase cDNA; conservation of functional domains and relevance to genetic polymorphisms.
Topics: Amino Acid Sequence; Animals; Binding Sites; Caenorhabditis elegans; Cattle; Cloning, Molecular; Dihydrouracil Dehydrogenase (NADP); DNA, Complementary; Drosophila; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Fluorouracil; Humans; Mice; Molecular Sequence Data; NADP; Oxidoreductases; Polymorphism, Genetic; Rats; Sequence Homology, Amino Acid; Swine; Uracil | 2002 |
gamma-Hydroxybutyric acid and 5-fluorouracil, metabolites of UFT, inhibit the angiogenesis induced by vascular endothelial growth factor.
Topics: Angiogenesis Inhibitors; Animals; Antimetabolites, Antineoplastic; Breast Neoplasms; Carcinoma; Carcinoma, Renal Cell; Chemotaxis; Colonic Neoplasms; DNA Replication; Drug Combinations; Endothelial Growth Factors; Endothelium, Vascular; Female; Fibroblast Growth Factor 2; Floxuridine; Fluorouracil; Humans; Intercellular Signaling Peptides and Proteins; Kidney Neoplasms; Lung Neoplasms; Lymphokines; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Neoplasm Proteins; Neovascularization, Pathologic; Prodrugs; Prostheses and Implants; Recombinant Proteins; Sodium Oxybate; Stomach Neoplasms; Tegafur; Tumor Cells, Cultured; Uracil; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Xenograft Model Antitumor Assays | 2001 |
[The uptake characteristics of 5-fluorouracil in the Caco-2 model system].
Topics: Antimetabolites, Antineoplastic; Caco-2 Cells; Fluorouracil; Humans; Hydrogen-Ion Concentration; Ouabain; Uracil | 1998 |
[A case of gastric cancer with paraaortic lymph node metastasis responding to preoperative chemotherapy and surviving 4 years and 4 months after total gastrectomy].
Topics: Adenocarcinoma, Scirrhous; Aged; Antineoplastic Combined Chemotherapy Protocols; Aorta; Cisplatin; Drug Administration Schedule; Female; Fluorouracil; Gastrectomy; Humans; Leucovorin; Lymph Nodes; Lymphatic Metastasis; Methotrexate; Stomach Neoplasms; Survivors; Tegafur; Uracil | 2002 |
[A case of complete response (CR) persisting for 2 years and 10 months from UFT-E in a patient with liver metastasis of gastric cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Drug Administration Schedule; Drug Combinations; Fluorouracil; Gastrectomy; Humans; Leucovorin; Liver Neoplasms; Lymph Node Excision; Male; Methotrexate; Middle Aged; Remission Induction; Stomach Neoplasms; Tegafur; Uracil | 2002 |
[A case of liver metastasis of rectal cancer demonstrating complete response to 5-FU + Leucovorin + UFT].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Drug Combinations; Fluorouracil; Humans; Leucovorin; Liver Neoplasms; Male; Middle Aged; Rectal Neoplasms; Remission Induction; Tegafur; Uracil | 2002 |
Novel disease-causing mutations in the dihydropyrimidine dehydrogenase gene interpreted by analysis of the three-dimensional protein structure.
Topics: Age of Onset; Amino Acids; Animals; Cells, Cultured; Child, Preschool; Crystallography, X-Ray; Dihydrouracil Dehydrogenase (NADP); Electron Transport; Exons; Fibroblasts; Fluorouracil; Gene Deletion; Genotype; Granulocytes; Humans; Infant; Infant, Newborn; Intellectual Disability; Leukocytes, Mononuclear; Models, Molecular; Motor Skills Disorders; Mutation; Mutation, Missense; Oxidoreductases; Phenotype; Point Mutation; Polymerase Chain Reaction; Polymorphism, Genetic; Pyrimidines; Swine; Thymine; Uracil | 2002 |
[Capsule instead of infusion--new oral chemotherapy option].
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colorectal Neoplasms; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Palliative Care; Tegafur; Uracil | 2002 |
Simple liquid chromatographic method for the determination of uracil and dihydrouracil plasma levels: a potential pretreatment predictor of 5-fluorouracil toxicity.
Topics: Antimetabolites, Antineoplastic; Chromatography, High Pressure Liquid; Fluorouracil; Humans; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Uracil | 2002 |
Development and characterization of a monoclonal antibody with cross-reactivity towards uracil and thymine, and its potential use in screening patients treated with 5-fluorouracil for possible risks.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Contraindications; Cross Reactions; Dihydrouracil Dehydrogenase (NADP); Enzyme Inhibitors; Fluorouracil; Humans; Hybridomas; Mice; Mice, Inbred BALB C; Oxidoreductases; Pyrimidines; Risk Factors; Thymine; Uracil | 2002 |
[A case of unresectable rectal cancer with liver and pulmonary metastases that responded remarkably to pharmacokinetic modulating chemotherapy].
Topics: Adenocarcinoma; Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Fluorouracil; Humans; Infusion Pumps, Implantable; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Quality of Life; Rectal Neoplasms; Tegafur; Uracil | 2002 |
[A trial of continuous and biweekly low-dose cisplatin and 5-FU with UFT chemotherapy for esophageal cancer].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Esophageal Neoplasms; Female; Fluorouracil; Humans; Infusions, Intra-Arterial; Male; Middle Aged; Survival Rate; Tegafur; Uracil | 2002 |
[A case of colon metastasis to the lung treated successfully with combined chemotherapy of CPT-11 and 5'-DFUR].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Drug Administration Schedule; Drug Combinations; Floxuridine; Fluorouracil; Humans; Irinotecan; Lung Neoplasms; Male; Middle Aged; Rectal Neoplasms; Tegafur; Uracil | 2002 |
Oral uracil/ftorafur (UFT) plus leucovorin as first-line chemotherapy and salvage therapy with weekly high-dose 5-fluorouracil/leucovorin for the treatment of metastatic colorectal cancer.
Topics: Adult; Aged; Antineoplastic Agents; Colonic Neoplasms; Diarrhea; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Leucovorin; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Metastasis; Rectal Neoplasms; Salvage Therapy; Tegafur; Uracil | 2002 |
Inhibiting 5-fluorouracil breakdown: a broken down approach to 5-fluorouracil modulation.
Topics: Antimetabolites, Antineoplastic; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Drug Synergism; Enzyme Inhibitors; Fluorouracil; Humans; Oxidoreductases; Uracil | 2002 |
Can eniluracil improve 5-fluorouracil therapy?
Topics: Antimetabolites, Antineoplastic; Dihydrouracil Dehydrogenase (NADP); Drug Synergism; Enzyme Inhibitors; Fluorouracil; Humans; Oxidoreductases; Uracil | 2002 |
[A case of multiple liver metastases from colon cancer successfully treated with modified pharmacokinetic modulating chemotherapy using Leucovorin].
Topics: Adenocarcinoma; Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Colectomy; Colonic Neoplasms; Combined Modality Therapy; Drug Administration Schedule; Fluorouracil; Humans; Leucovorin; Liver Neoplasms; Male; Middle Aged; Remission Induction; Tegafur; Uracil | 2002 |
[Two patients with recurrent colon cancer who underwent surgery following a combination of irinotecan and UFT].
Topics: Adenocarcinoma; Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colectomy; Colonic Neoplasms; Combined Modality Therapy; Drug Administration Schedule; Fluorouracil; Humans; Irinotecan; Leucovorin; Lung Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Tegafur; Uracil | 2002 |
[A case of postoperative hepatic metastasis from gastric cancer responding to hepatic arterial infusion chemotherapy of paclitaxel].
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Drug Administration Schedule; Drug Combinations; Fluorouracil; Gastrectomy; Humans; Liver Neoplasms; Male; Paclitaxel; Stomach Neoplasms; Tegafur; Uracil | 2002 |
[5-FU pharmacokinetic study of 5-FU hepato-arterial infusion with oral UFT].
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Fluorouracil; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Tegafur; Uracil | 2002 |
Role of body surface area in dosing of investigational anticancer agents in adults, 1991-2001.
Topics: Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Body Surface Area; Clinical Trials, Phase I as Topic; Cytosine; Dacarbazine; Dioxolanes; Docosahexaenoic Acids; Dose-Response Relationship, Drug; Drug Administration Schedule; Drugs, Investigational; Female; Fluorouracil; Humans; Infusions, Intravenous; Male; Paclitaxel; Retrospective Studies; Temozolomide; Uracil | 2002 |
A study to evaluate the pharmacokinetics of oral 5-fluorouracil and eniluracil after concurrent administration to patients with refractory solid tumours and varying degrees of renal impairment (FUMA1005).
Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Drug Therapy, Combination; Enzyme Inhibitors; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasms; Renal Insufficiency; Uracil | 2003 |
[Modified pharmacokinetic modulation chemotherapy (PMC) with medication of UFT and intraarterial infusion of 5-FU for advanced unresectable HCC].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Drug Combinations; Female; Fluorouracil; Hepatic Artery; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Survival Rate; Tegafur; Uracil | 2002 |
[Combined determination of urine uracil levels and plasma 5-FU clearance for a simple order-made treatment with anticancer agents of FU derivative].
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Dihydrouracil Dehydrogenase (NADP); Drug Screening Assays, Antitumor; Female; Fluorouracil; Gastrointestinal Neoplasms; Humans; Male; Metabolic Clearance Rate; Middle Aged; Oxidoreductases; Uracil | 2003 |
Design and synthesis of the tumor-activated prodrug of dihydropyrimidine dehydrogenase (DPD) inhibitor, RO0094889 for combination therapy with capecitabine.
Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Carcinoma, Non-Small-Cell Lung; Cytidine Deaminase; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Drug Design; Drug Stability; Esterases; Female; Fluorouracil; Humans; Lung Neoplasms; Mice; Oxidoreductases; Prodrugs; Thymidine Phosphorylase; Tissue Distribution; Uracil; Uterine Cervical Neoplasms; Xenograft Model Antitumor Assays | 2003 |
Dihydropyrimidine dehydrogenase (DPD) activity in gastric cancer tissue and effect of DPD inhibitory fluoropyrimidines.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Dihydrouracil Dehydrogenase (NADP); Disease Progression; Drug Combinations; Enzyme Inhibitors; Fluorouracil; Humans; Japan; Leucovorin; Liver Neoplasms; Lymphatic Metastasis; Oxidoreductases; Oxonic Acid; Peritoneal Neoplasms; Prognosis; Pyridines; Statistics as Topic; Stomach Neoplasms; Survival Analysis; Tegafur; Treatment Outcome; Uracil | 2003 |
NICE recommends new treatment for breast and bowel cancer.
Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Colonic Neoplasms; Deoxycytidine; Docetaxel; Female; Fluorouracil; Humans; Paclitaxel; Practice Guidelines as Topic; Taxoids; Tegafur; Uracil | 2003 |
Determination of uracil in 5-fluorouracil substance by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Fluorouracil; Uracil | 2003 |
A dose-escalating study of oral eniluracil/5-fluorouracil plus oxaliplatin in patients with advanced gastrointestinal malignancies.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cohort Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fluorouracil; Gastrointestinal Neoplasms; Humans; Male; Maximum Tolerated Dose; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Uracil | 2003 |
Effects of oral UFT combined with or without zoledronic acid on bone metastasis in the 4T1/luc mouse breast cancer.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; Bone Neoplasms; Diphosphonates; Disease Models, Animal; Drug Combinations; Female; Fluorouracil; Imidazoles; Luciferases; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Osteoclasts; Tegafur; Uracil; Zoledronic Acid | 2003 |
[A case of multiple lung metastases from colon cancer after sigmoidectomy treated effectively by chemotherapy].
Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colon, Sigmoid; Drug Administration Schedule; Drug Combinations; Fluorouracil; Humans; Irinotecan; Lung Neoplasms; Male; Middle Aged; Postoperative Complications; Sigmoid Neoplasms; Tegafur; Uracil | 2003 |
Plasma concentrations of 5-fluorouracil and F-beta-alanine following oral administration of S-1, a dihydropyrimidine dehydrogenase inhibitory fluoropyrimidine, as compared with protracted venous infusion of 5-fluorouracil.
Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; beta-Alanine; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Enzyme Inhibitors; Fluorouracil; Gastrointestinal Neoplasms; Humans; Infusions, Intravenous; Male; Middle Aged; Oxidoreductases; Oxonic Acid; Pyridines; Tegafur; Uracil | 2003 |
A cost comparison of oral tegafur plus uracil/folinic acid and parenteral fluorouracil for colorectal cancer in Canada.
Topics: Administration, Oral; Aged; Antimetabolites, Antineoplastic; Canada; Clinical Trials, Phase III as Topic; Colorectal Neoplasms; Drug Combinations; Drug Therapy, Combination; Female; Fluorouracil; Health Care Costs; Humans; Infusions, Parenteral; Leucovorin; Male; Middle Aged; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Retrospective Studies; Tegafur; Uracil | 2003 |
[Influence of 5-fluorouracil on the in vitro multiplication of a strain of Klebsiella aerobacter].
Topics: Enterobacter; Fluorouracil; In Vitro Techniques; Klebsiella; Leadership; Sprains and Strains; Uracil | 1958 |
Clinical studies with 5-fluorouracil.
Topics: Biomedical Research; Fluorouracil; Neoplasms; Uracil | 1958 |
The influence of 5-fluorouracil on tobacco-mosaic virus production in tobacco-leaf discs.
Topics: Fluorouracil; Nicotiana; Tobacco Mosaic Virus; Uracil; Viruses | 1958 |
Effect of 5-fluorouracil on a uracil-requiring mutant of Escherichia coli.
Topics: Escherichia coli; Fluorouracil; Uracil | 1958 |
Enzymic ribosidation and ribotidation of 5-fluorouracil by extracts of the Ehrlich-ascites tumor.
Topics: Antineoplastic Agents; Ascites; Fluorouracil; Neoplasms; Uracil | 1958 |
Studies of 5-fluorouracil in the treatment of L1210 leukemia in mice.
Topics: Animals; Antineoplastic Agents; Fluorouracil; Leukemia, Experimental; Mice; Uracil | 1959 |
Effect of 5-fluorouracil on mammary tumors in mice.
Topics: Animals; Antineoplastic Agents; Fluorouracil; Mice; Neoplasms, Experimental; Uracil | 1959 |
Further clinical studies with 5-fluorouracil.
Topics: Antineoplastic Agents; Biomedical Research; Fluorouracil; Uracil | 1959 |
Possible enzymic mechanism for the development of resistance against fluorouracil in ascites tumours.
Topics: Antineoplastic Agents; Ascites; Biochemical Phenomena; Fluorouracil; Neoplasms; Uracil | 1959 |
The influence of fluorouracil containing compounds upon growth and metabolism of Bacillus cereus.
Topics: Antineoplastic Agents; Bacillus cereus; Biological Phenomena; Fluorouracil; Nucleic Acids; Physiological Phenomena; Uracil | 1959 |
The effect of 5-fluorouracil on bacterial protein and ribonucleic acid synthesis.
Topics: Bacteria; Bacterial Proteins; Biochemical Phenomena; Fluorouracil; Proteins; RNA; Uracil | 1961 |
The inhibition of bacteriophage protein synthesis by 5-fluorouracil.
Topics: Bacteriophages; Fluorouracil; Protein Biosynthesis; Proteins; Uracil | 1961 |
[Experimental enteropathy induced by 5-fluorouracil in the rat].
Topics: Animals; Disease; Fluorouracil; Intestinal Diseases; Intestine, Small; Intestines; Rats; Uracil | 1961 |
Clinical experience with 5-fluorouracil (NSC-19893) in the treatment of malignant disease.
Topics: Fluorouracil; Neoplasms; Uracil | 1960 |
Turnover of thymidine in the DNA of marrow and intestinal mucosa in mice, and its response to administration of 5-fluorouracil.
Topics: Animals; Antineoplastic Agents; Bone Marrow; DNA; Fluorouracil; Intestinal Mucosa; Mice; Nucleosides; Nucleotides; Thymidine; Uracil | 1961 |
The potentiation of radiation effects with 5-fluoro-uracil.
Topics: Aged; Carcinoma, Squamous Cell; Esophagitis; Fluorouracil; Humans; Lung; Lung Neoplasms; Male; Middle Aged; Neoplasms; Radiotherapy; Radiotherapy Dosage; Uracil | 1960 |
Preliminary pharmacologic observations on the concomitant use of x-ray and 5-fluorouracil in human malignancies.
Topics: Antineoplastic Agents; Fluorouracil; Neoplasms; Uracil; X-Rays | 1961 |
[Inhibition of the development of the Rous sarcoma virus by 5-fluorouracil in tissue culture].
Topics: Fluorouracil; Neoplasms; Research Design; Rous sarcoma virus; Uracil; Viruses | 1961 |
Patterns of cellular controls operating in bacteriophage reproduction. I. Effect of 5-fluorouracil in the multiplication of several coliphages.
Topics: Bacteriophages; Coliphages; Escherichia coli; Fluorouracil; Uracil | 1960 |
One year's clinical experience with 5-fluorouracil and x-ray-a preliminary report.
Topics: Antineoplastic Agents; Fluorouracil; Neoplasms; Uracil; X-Rays | 1961 |
Treatment of advanced neoplastic disease with 5-fluorouracil and irradiation.
Topics: Fluorouracil; Neoplasms; Uracil | 1960 |
Sensitive stages for the production of developmental abnormalities in mice with 5-fluorouracil.
Topics: Animals; Congenital Abnormalities; Fluorouracil; Mice; Uracil | 1960 |
5-Fluorouracil and mucopeptide biosynthesis by Staphylococcus aureus.
Topics: Fluorouracil; Mucoproteins; Peptides; Peptidoglycan; Staphylococcal Infections; Staphylococcus; Staphylococcus aureus; Uracil | 1960 |
Patterns of cellular controls operating in bacteriophage reproduction. II. Effect of 5-fluorouracil on metabolic events in bacteria infected with coliphage T2r.
Topics: Bacteria; Bacteriophages; Biochemical Phenomena; Coliphages; DNA; Escherichia coli; Fluorouracil; Proteins; Uracil | 1960 |
The action of 5-fluorouracil on the nucleic acid metabolism of pseudorabies virus-infected and noninfected rabbit kidney cells.
Topics: Animals; Antineoplastic Agents; Epithelial Cells; Fluorouracil; Herpesvirus 1, Suid; Kidney; Nucleic Acids; Pseudorabies; Rabbits; Uracil | 1961 |
Observations on the use of 5-fluorouracil in metastatic carcinoma of the breast.
Topics: Antineoplastic Agents; Breast; Breast Neoplasms; Carcinoma; Fluorouracil; Humans; Uracil | 1961 |
Clinical experience with 5-fluorouracil.
Topics: Antineoplastic Agents; Fluorouracil; Uracil | 1961 |
Development of a strain of psittacosis virus partially resistant to 5-fluorouracil in a tissue culture system.
Topics: Antineoplastic Agents; Chlamydia; Chlamydophila psittaci; Fluorouracil; Psittacosis; Uracil | 1961 |
The effect of 5-fluorouracil upon carcinomas of the gastrointestinal tract and related organs.
Topics: Biliary Tract; Biliary Tract Neoplasms; Digestive System Neoplasms; Fluorouracil; Gastrointestinal Tract; Humans; Neoplasms; Pancreatic Neoplasms; Uracil | 1961 |
Combined therapy of inoperable lung carcinoma with 5-fluorouracil and irradiation.
Topics: Antineoplastic Agents; Fluorouracil; Lung Neoplasms; Psychotherapy, Multiple; Uracil | 1961 |
5-Fluorouracil in clinical cancer experience with 155 patients.
Topics: Antineoplastic Agents; Fluorouracil; Neoplasms; Uracil | 1960 |
Metabolism of uracil and 5-fluorouracil by drug-sensitive and by drug-resistant bacteria.
Topics: Bacteria; Biochemical Phenomena; Fluorouracil; Humans; Uracil | 1960 |
Clinical experiences with 5-fluorouracil.
Topics: Antineoplastic Agents; Fluorouracil; Uracil | 1960 |
Use of 5-fluorouracil in treatment of bladder carcinomas.
Topics: Antineoplastic Agents; Carcinoma; Fluorouracil; Uracil; Urinary Bladder Neoplasms | 1960 |
The potentiation of radiation effects with 5-fluorouracil.
Topics: Antineoplastic Agents; Fluorouracil; Neoplasms; Uracil | 1960 |
5-Fluorouracil and its ribosides.
Topics: Antineoplastic Agents; Fluorouracil; Glycosides; Nucleosides; Nucleotides; Uracil | 1960 |
Potentiation of 5-fluorouracil by combination chemotherapy in animals.
Topics: Antineoplastic Agents; Drug Therapy, Combination; Fluorouracil; Uracil | 1960 |
Toxicity studies of 5-fluorouracil used as an adjunct to surgery.
Topics: Agranulocytosis; Fluorouracil; Humans; Leukopenia; Surgical Procedures, Operative; Uracil | 1960 |
Toxicity studies of 5-fluorouracil used as an adjunct to surgery.
Topics: Fluorouracil; Nutrition Disorders; Research; Uracil | 1960 |
The clinical evaluation of 5-fluorouracil and 5-fluoro-2'-deoxyuridine in solid tumors in adults: a progress report.
Topics: Antineoplastic Agents; Deoxyuridine; Fluorouracil; Neoplasms; Nucleosides; Nucleotides; Research Report; Uracil | 1960 |
A clinical study of 5-fluorouracil.
Topics: Antineoplastic Agents; Biomedical Research; Fluorouracil; Uracil | 1959 |
Studies on the incorporation of 5-fluorouracil into a virus nucleic acid.
Topics: Fluorouracil; Nucleic Acids; RNA; Uracil; Viruses | 1959 |
Cancer chemotherapy with 5-fluorouracil alone and in combination with x-ray therapy.
Topics: Fluorouracil; Humans; Neoplasms; Uracil; X-Ray Therapy | 1961 |
Five years clinical experience with 5-fluorouracil.
Topics: Antineoplastic Agents; Fluorouracil; Uracil | 1962 |
A preliminary report on the use of 5-fluorouracil in malignant disease.
Topics: Antineoplastic Agents; Fluorouracil; Neoplasms; Uracil | 1962 |
Induced phenotypic reversion by 8-azaguanine and 5-fluorouracil.
Topics: Azaguanine; Fluorouracil; Neurospora; Purines; RNA; Uracil | 1962 |
The effect of ultraviolet irradiation on 5-fluorouracil-pretreated bacteria.
Topics: Bacteria; Escherichia coli; Fluorouracil; Radiation Protection; Ultraviolet Rays; Uracil | 1962 |
Cytological effects of 5-fluorouracil.
Topics: Cell Biology; Fluorouracil; Uracil | 1962 |
Effects of 5-fluorouracil on the adrenals of normal and tumor-bearing rats.
Topics: Adrenal Glands; Animals; Cortisone; Fluorouracil; Neomycin; Neoplasms; Rats; Uracil | 1962 |
[Thyroid lesions induced by 5-fluorouracil in the rat].
Topics: Animals; Fluorouracil; Rats; Thyroid Gland; Uracil; Viscera | 1961 |
Reversal of mutant phenotypes by 5-fluorouracil: an approach to nucleotide sequences in messenger-RNA.
Topics: Bacteriophages; Base Sequence; Fluorouracil; Phenotype; RNA, Messenger; Uracil | 1962 |
Observations on the combined use of 5-fluorouracil and 2 Mev radiation in advanced solid tumors in man.
Topics: Antineoplastic Agents; Fluorouracil; Neomycin; Neoplasms; Radiation; Research; Uracil | 1961 |
Comparison of 5-fluorouracil and 5-fluoro-2'-deoxyuridine in the treatment of far-advanced breast and colon lesions.
Topics: Antineoplastic Agents; Breast Neoplasms; Colonic Neoplasms; Deoxyuridine; Fluorouracil; Humans; Nucleosides; Nucleotides; Uracil | 1962 |
[Research on the antimitotic properties of antagonists of natural pyrimidine bases. I. 5-Fluorouracil and related compounds].
Topics: Antimitotic Agents; Antineoplastic Agents; Fluorouracil; Pyrimidines; Research; Uracil | 1962 |
The treatment of recurrent or metastatic breast cancer with emphasis on the use of 5-fluorouracil.
Topics: Antineoplastic Agents; Breast; Breast Neoplasms; Fluorouracil; Humans; Uracil | 1962 |
The effects of 5-fluorouracil in patients with incurable cancer.
Topics: Fluorouracil; Humans; Neoplasms; Uracil | 1962 |
Skin changes in patients treated with 5-fluorouracil.
Topics: Fluorouracil; Humans; Skin; Skin Neoplasms; Uracil | 1962 |
Observations on the concomitant use of x-rays and 5-fluorouracil in human malignant neoplasms.
Topics: Antineoplastic Agents; Fluorouracil; Neoplasms; Uracil; X-Rays | 1962 |
Further observations on the concomitant use of x rays and 5-fluorouracil in neoplasms of humans.
Topics: Antineoplastic Agents; Fluorouracil; Neoplasms; Uracil; X-Rays | 1962 |
Effect of 5-fluorouracil on hepatic induced increase of tryptophan-pyrrolase.
Topics: Biochemical Phenomena; Enzymes; Fluorouracil; Liver; Tryptophan; Tryptophan Oxygenase; Uracil | 1961 |
Studies on resistance against 5-fluorouracil. II. Thymidylate synthetase from drug-resistant tumor lines.
Topics: Enzymes; Fluorouracil; Humans; Neoplasms; Thymidylate Synthase; Uracil | 1962 |
Advanced neoplastic disease. Treatment with 5-fluorouracil and irradiation.
Topics: Antineoplastic Agents; Fluorouracil; Neoplasms; Uracil | 1961 |
Treatment of far-advanced cancer with 5-fluorouracil, used alone and in combination with irradiation. Incidence and duration of remission and survival-time data in 223 patients.
Topics: Antineoplastic Agents; Fluorouracil; Incidence; Neoplasms; Uracil | 1962 |
A comparative study of 5-fluorouracil (FU), 5-fluorodeoxyuridine (FUDR), and methotrexate (MTX)-progress report.
Topics: Antineoplastic Agents; Floxuridine; Fluorouracil; Folic Acid Antagonists; Methotrexate; Nucleosides; Nucleotides; Research Report; Uracil | 1962 |
The clinical excursion into 5-fluoro-uracil.
Topics: Fluorouracil; Humans; Neoplasms; Uracil | 1962 |
5-Fluorouracil in the treatment of inoperable carcinoma of the colon and rectum.
Topics: Antineoplastic Agents; Carcinoma; Colonic Neoplasms; Fluorouracil; Humans; Rectal Neoplasms; Rectum; Uracil | 1962 |
Various methods of administering 5-fluorouracil.
Topics: Antineoplastic Agents; Fluorouracil; Uracil | 1962 |
Intra-arterial infusion of maligancies with 5-fluorouracil.
Topics: Antineoplastic Agents; Fluorouracil; Infusions, Intra-Arterial; Uracil | 1961 |
Intra-arterial infusion of tumors with 5-fluorouracil.
Topics: Antineoplastic Agents; Fluorouracil; Infusions, Intra-Arterial; Infusions, Parenteral; Neoplasms; Uracil | 1962 |
The mechanism of an osmotic instability induced in E. coli K-12 by 5-fluorouracil.
Topics: Escherichia coli; Fluorouracil; Osmosis; Uracil | 1962 |
[On nucleic acids].
Topics: DNA; Fluorouracil; Metabolism; Neoplasms; Nucleic Acids; Proteins; Purines; Pyrimidines; Radiation Effects; Radiation Genetics; RNA; RNA, Neoplasm; Uracil; Uracil Nucleotides | 1963 |
Antimitotic action of 5-(2'-bromo-acetamido)-uracil on the Ehrlich ascites tumor.
Topics: Animals; Antimitotic Agents; Antineoplastic Agents; Carcinoma; Carcinoma, Ehrlich Tumor; Fluorouracil; Pyrimidines; Uracil | 1962 |
[Studies on the mechanism of induction. IV. The effect of 5-bromouracil on induction with 5-fluorouracil and 5-fluorodeoxyuridine].
Topics: Bromouracil; Coliphages; Escherichia coli; Floxuridine; Fluorouracil; Uracil | 1963 |
[Studies on the mechanism of induction. III. The effect of uracil on the induction effect of 5-fluorouracil and 5-fluorodeoxyuridine].
Topics: Coliphages; Culture Media; Escherichia coli; Floxuridine; Fluorouracil; Uracil | 1963 |
Ultraviolet absorption spectra and structure of halogenated uracils and their glycosides.
Topics: Floxuridine; Fluorouracil; Glycosides; Nucleosides; Uracil | 1963 |
Effects of uracil and thymidine on the development of resistance to 5-fluorouracil in Pediococcus cerevisiae.
Topics: Deoxyuridine; Fluorouracil; Pediococcus; Thymidine; Uracil | 1963 |
An evaluation of 5-fluorouracil in malignant disease.
Topics: Antineoplastic Agents; Fluorouracil; Neoplasms; Uracil | 1961 |
A clinical study of 5-fluorouracil in a variety of far advanced human malignancies.
Topics: Antineoplastic Agents; Biomedical Research; Fluorouracil; Humans; Neoplasms; Uracil | 1962 |
Some observations of the effects of 5-fluorouracil in the treatment of malignant tumors.
Topics: Fluorouracil; Humans; Neoplasms; Uracil | 1962 |
The use of combination 5-fluorouracil and supervoltage irradiation therapy in advanced carcinoma of the urinary bladder--a preliminary report.
Topics: Carcinoma; Cell- and Tissue-Based Therapy; Fluorouracil; Humans; Multiple Myeloma; Plasma Cells; Uracil; Urinary Bladder Neoplasms | 1962 |
5-Fluorouracil inhibition of testosterone-stimulated growth of seminal vesicles.
Topics: Anti-Bacterial Agents; Fluorouracil; Humans; Male; Pyridones; Seminal Vesicles; Testosterone; Uracil | 1962 |
Growth inhibition of sarcoma 180 by hormone antisera and 5-fluor-ouracil.
Topics: Animals; Fluorouracil; Growth Hormone; Human Growth Hormone; Humans; Immune Sera; Sarcoma 180; Uracil | 1963 |
[STUDIES ON THE MECHANISM OF INDUCTION. V. EXPERIMENTS ON ANALYSIS OF THE INDUCTIVE EFFECT OF HALOGENATED BASES AND THEIR DESOXYRIBONUCLEOSIDES].
Topics: Coliphages; Culture Media; Cytosine Nucleotides; Deoxyribonucleosides; Escherichia coli; Floxuridine; Fluorouracil; Halogenation; Uracil; Uracil Nucleotides | 1963 |
NUCLEIC ACID METABOLISM AND BACTERIOPHAGE MULTIPLICATION: EFFECTS OF 5-FLUOROURACIL ON COLIPHAGE SYNTHESIS.
Topics: Bacteriophages; Coliphages; DNA; DNA, Viral; Fluorouracil; RNA; RNA, Viral; Thymidine; Uracil | 1963 |
INDUCTION BY 5-FLUOROURACIL OF BACTERIOPHAGE DEVELOPMENT IN LYSOGENIC E. COLI K12 (LAMBDA).
Topics: Bacteriophages; Coliphages; Escherichia coli; Fluorouracil; Lysogeny; Research; Thymidine; Uracil | 1963 |
URIDINE DIPHOSPHATE GLUCOSE DEHYDROGENASE. PH DEPENDENCE OF THE REACTIONS WITH THE 5-FLUOROURACIL AND 6-AZAURACIL ANALOGUES OF URIDINE DIPHOSPHATE GLUCOSE.
Topics: Alcohol Oxidoreductases; Fluorouracil; Glucose; Hydrogen-Ion Concentration; Research; Uracil; Uracil Nucleotides; Uridine Diphosphate Glucose; Uridine Diphosphate Glucose Dehydrogenase | 1963 |
[NEW ANTIBLASTIC AGENTS].
Topics: Antineoplastic Agents; Colonic Neoplasms; Ethoglucid; Fluorouracil; Neoplasm Metastasis; Neoplasms; Pharmacology; Stomach Neoplasms; Toxicology; Uracil; Vincristine | 1963 |
THE EFFECT OF NATURAL AND UNNNATURAL PYRIMIDINES AND PYRIMIDINE NUCLEOSIDES ON THE PHOSPHOROLYSIS OF 5-IODODEOXYURIDINE BY MOUSE LIVER EXTRACT.
Topics: Animals; Chromatography; Deoxyuridine; Floxuridine; Fluorouracil; Idoxuridine; Iodine Isotopes; Liver; Liver Extracts; Metabolism; Mice; Nucleosides; Pharmacology; Phosphotransferases; Pyrimidine Nucleosides; Pyrimidines; Research; Thymidine; Thymine; Uracil | 1964 |
THE INFLUENCE OF PHENOBARBITAL ADMINISTRATION UPON THE "SOLUBLE" NADP-REQUIRING ENZYMES IN LIVER.
Topics: Aminopyrine; Benzopyrenes; Citrates; Diphenhydramine; Ethionine; Fluorouracil; Gluconates; Hexosephosphates; Isocitrate Dehydrogenase; Liver; Mercaptopurine; Methylcholanthrene; NADP; Oxidoreductases; Pharmacology; Phenobarbital; Phenylalanine; Rats; Research; Uracil | 1964 |
URACIL: FAILURE TO RESTORE DNA SYNTHESIS WHILE RELIEVING 5-FLUOROURACIL-INDUCED INHIBITION.
Topics: Adenine; Bacillus cereus; Carbon Isotopes; DNA; DNA, Bacterial; Fluorouracil; Formates; Guanine; Hypoxanthines; Metabolism; Pharmacology; Proteins; Research; RNA; Uracil | 1964 |
DIFFERENTIATION BY IMMUNODIFFUSION AND BY QUANTITATIVE IMMUNOFLUORESCENCE BETWEEN 5-FLUOROURACIL-TREATED AND NORMAL CELLS FROM A TOXINOGENIC STAPHYLOCOCCUS AUREUS STRAIN.
Topics: Antigens; Canada; Chromatography; DNA; DNA, Bacterial; Fluorescent Antibody Technique; Fluorouracil; Immunochemistry; Immunodiffusion; Pharmacology; Precipitin Tests; Research; RNA; RNA, Bacterial; Staphylococcus; Staphylococcus aureus; Uracil | 1964 |
HOST-DEPENDENT MUTANTS OF THE BACTERIOPHAGE F2. IV. ON THE BIOSYNTHESIS OF A VIRAL RNA POLYMERASE.
Topics: Bacteriophages; Chloramphenicol; DNA-Directed RNA Polymerases; Fluorouracil; Histidine; Ligases; Metabolism; Mutation; Pharmacology; Research; RNA; RNA, Viral; Tissue Culture Techniques; Uracil; Uracil Nucleotides; Virus Cultivation | 1964 |
SUBSTRATE SPECIFICITY AND INDUCTION OF THYMIDINE PHOSPHORYLASE IN ESCHERICHIA COLI.
Topics: Chloramphenicol; Escherichia coli; Fluorouracil; Glucosyltransferases; Nucleosides; Pharmacology; Research; Substrate Specificity; Thymidine; Thymidine Phosphorylase; Uracil | 1964 |
ANTIMITOTIC EFFECTS OF CHLORAMPHENICOL AND OTHER INHIBITORY AGENTS IN CHLAMYDOMONAS.
Topics: Antimitotic Agents; Cell Division; Cell Nucleus; Chlamydia; Chlamydomonas; Chloramphenicol; Chlorides; DNA; Floxuridine; Fluorouracil; Glycols; Mercaptoethanol; Nucleosides; Pharmacology; Proteins; Radiation Effects; Research; RNA; Uracil | 1964 |
[MACROMOLECULAR MODIFICATIONS IN A PATHOGENIC BACTERIUM BY MEANS OF ANTIMETABOLITES OF NUCLEIC ACIDS: COMPARATIVE EFFECTS OF 5-FLUOROURACIL AND ACRIDINE ORANGE ON VIRULENCE INDICATORS IN STAPHYLOCOCCUS AUREUS].
Topics: Acridine Orange; Acridines; Antigens; Antimetabolites; DNA; DNA, Bacterial; Fluorescence; Fluorouracil; Immunodiffusion; Microscopy; Microscopy, Fluorescence; Pharmacology; Research; RNA; RNA, Bacterial; Staphylococcal Infections; Staphylococcus; Staphylococcus aureus; Thymine; Uracil; Virulence | 1964 |
INFLUENCE OF PURINE AND PYRIMIDINE COMPOUNDS ON DNA-SYNTHESIS OF ASCITES-TUMOUR CELLS.
Topics: Animals; Ascites; Carcinoma, Ehrlich Tumor; Cytosine Nucleotides; DNA; DNA, Neoplasm; Fluorouracil; Metabolism; Neoplasms, Experimental; Nucleotides; Pharmacology; Phosphorus Isotopes; Purines; Pyrimidines; Research; Thymine; Uracil; Uracil Nucleotides | 1964 |
[STUDY OF MUTANTS RESISTANT TO 5-FLUOROURACIL IN COPRINUS].
Topics: Basidiomycota; Carbon Isotopes; Coprinus; Drug Resistance; Drug Resistance, Microbial; Fluorouracil; Metabolism; Molecular Biology; Mutation; Pyrimidines; Research; Uracil; Uracil Nucleotides | 1965 |
UPTAKE AND INCORPORATION OF THYMINE, THYMIDINE, URACIL, URIDINE, AND 5-FLUOROURACIL INTO THE NUCLEIC ACIDS OF BACILLUS SUBTILIS.
Topics: Bacillus subtilis; Carbon Isotopes; DNA; DNA, Bacterial; Fluorouracil; Metabolism; Nucleosides; Research; RNA; RNA, Bacterial; Thymidine; Thymine; Tritium; Uracil; Uridine | 1965 |
PARTIAL SATISFACTION OF A URACIL REQUIREMENT BY 5-FLUOROURACIL.
Topics: Coliphages; Escherichia coli; Fluorouracil; Personal Satisfaction; Research; Uracil | 1965 |
CLOSED PELVIC PERFUSION IN ADVANCED GYNECOLOGIC CANCER.
Topics: Catheterization; Chemotherapy, Cancer, Regional Perfusion; Cyclophosphamide; Female; Fluorouracil; Folic Acid; Genital Neoplasms, Female; Geriatrics; Humans; Lymphography; Neoplasms; Nitrogen Mustard Compounds; Palliative Care; Pelvis; Postoperative Care; Prognosis; Toxicology; Uracil; Uracil Mustard; Urography; Uterine Cervical Neoplasms; Vulvar Neoplasms | 1965 |
PYRIMIDINE METABOLISM IN TISSUE CULTURE CELLS DERIVED FROM RAT HEPATOMAS. I. SUSPENSION CELL CULTURES DERIVED FROM THE NOVIKOFF HEPATOMA.
Topics: Animals; Carcinoma, Hepatocellular; Cell Culture Techniques; Floxuridine; Fluorouracil; Glycine; Liver Neoplasms; Liver Neoplasms, Experimental; Metabolism; Methotrexate; Mutation; Neoplasms; Neoplasms, Experimental; Nucleosides; Pharmacology; Pyrimidines; Rats; Research; Serine; Thymidine; Thymidine Kinase; Thymine; Tissue Culture Techniques; Toxicology; Uracil | 1965 |
[ON THE EFFECT OF 5-BROMOURACIL AND 5-FLUOROURACIL ON THE VIRUS INDUCTION OF A LYSOGENIC THYMINE-LESS MUTANT OF E. COLI BY MEANS OF ULTRAVIOLET RAYS].
Topics: Bromouracil; Coliphages; DNA; Escherichia coli; Fluorouracil; Lysogeny; Research; Thymine; Ultraviolet Rays; Uracil; Virus Activation | 1964 |
GENE REGULATION DURING BACTERIOPHAGE T4 DEVLOPMENT. I. PHENOTYPIC REVERSION OF T4 AMBER MUTANTS BY 5-FLUOROURACIL.
Topics: Amber; Bacteriophage T4; Coliphages; DNA; DNA, Viral; Fluorouracil; Kinetics; Models, Theoretical; Molecular Biology; Mutation; Nucleotidyltransferases; Pharmacology; Proteins; Research; RNA; RNA, Messenger; Uracil; Viral Proteins | 1965 |
Massive incorporation of 5-fluorouracil into a bacterial ribonucleic acid.
Topics: Biochemical Phenomena; Escherichia coli; Fluorouracil; RNA; Uracil | 1959 |
Use of 5-fluorouracil in the management of advanced maligancies in childhood.
Topics: Disease Management; Fluorouracil; Uracil | 1960 |
Reduction of 5-fluorouracil toxicity in man with retention of anticancer effects by prolonged intravenous administration in 5 per cent dextrose.
Topics: Administration, Intravenous; Drug-Related Side Effects and Adverse Reactions; Fluorouracil; Glucose; Humans; Neoplasms; Uracil | 1960 |
Studies on fluorinated pyrimidines. IX. The degradation of 5-fluorouracil-6-C14.
Topics: Antineoplastic Agents; Fluorouracil; Halogenation; Pyrimidines; Uracil | 1960 |
Evaluation of 5-fluorouracil in the treatment of cancer.
Topics: Fluorouracil; Neoplasms; Uracil | 1960 |
Effect of 5-fluorouracil on noncancerous tissue growth.
Topics: Fluorouracil; Uracil | 1959 |
Factors to be considered in the clinical evaluation of a new chemotherapeutic agent (5-fluorouracil).
Topics: Antineoplastic Agents; Fluorouracil; Uracil | 1962 |
Permeability of Ehrlich cells to uracil, thymine and fluorouracil.
Topics: Fluorouracil; Humans; Neoplasms; Permeability; Thymine; Uracil | 1962 |
Studies on the feasibility of adjuvant chemotherapy with 5-fluorouracil (FU) and 5-fluoro-2'-deoxyuridine (FUDR) in the immediate postoperative period.
Topics: Antineoplastic Agents; Chemotherapy, Adjuvant; Deoxyuridine; Floxuridine; Fluorouracil; Humans; Postoperative Period; Pyrimidines; Uracil | 1962 |
The role of 5-fluorouracil in malignant disease.
Topics: Antineoplastic Agents; Fluorouracil; Neoplasms; Uracil | 1961 |
Tumors of the skin. II. Keratoacanthoma; local effct of 5-fluorouracil.
Topics: Fluorouracil; Humans; Keratoacanthoma; Neoplasms; Skin; Skin Neoplasms; Uracil | 1962 |
Alterations in the administration of 5-fluorouracil; experiences with two-hour infusions.
Topics: Fluorouracil; Uracil | 1961 |
[Inhibition of the multiplication in vitro of poliomyelitis virus by the action of guanidine. XI. Potentiation of the anti-poliomyelitic effect of guanidine by 5-fluorouracil].
Topics: Amidines; Fluorouracil; Guanidine; Guanidines; In Vitro Techniques; Poliomyelitis; Poliovirus; Uracil | 1962 |
The incorporation of 5-fluoro-uracil into poliovirus.
Topics: Fluorouracil; Poliomyelitis; Poliovirus; RNA; Uracil | 1962 |
[Problems in chemotherapy illustrated by the cytostatic 5-fluoruracil and the leukemias].
Topics: Antineoplastic Agents; Cytostatic Agents; Fluorouracil; Leukemia; Uracil | 1961 |
Combined action of 5-fluorouracil and other cytotoxic agents with crystalline ribonuclease on mouse ascites tumor.
Topics: Animals; Antineoplastic Agents; Ascites; Carcinoma, Ehrlich Tumor; Cytotoxins; Fluorouracil; Mice; Neoplasms, Experimental; Ribonucleases; Uracil | 1961 |
Studies on resistance against 5-fluorouracil. I. Enzymes of the uracil pathway during development of resistance.
Topics: Fluorouracil; Humans; Phosphorylases; Phosphotransferases; Uracil | 1962 |
Biochemical changes during treatment with 5-fluorouracil.
Topics: Antineoplastic Agents; Fluorouracil; Neoplasms; Phosphotransferases; Uracil | 1962 |
The morphology of noninfective pseudorabies virus produced by cells treated with 5-fluorouracil.
Topics: Fluorouracil; Herpesvirus 1, Suid; Uracil; Viruses | 1962 |
Massive intra-aortic injections of nitrogen mustard (Dichloren), 5-fluorouracil, nitromin, and endoxan prior to roentgen irradiation for advanced tumors of the uterus.
Topics: Antineoplastic Agents; Cyclophosphamide; Female; Fluorouracil; Humans; Mechlorethamine; Neoplasms; Nitrogen Mustard Compounds; Uracil; Uterine Neoplasms | 1962 |
Use of 5-fluorouracil in disseminated solid neoplasms.
Topics: Antineoplastic Agents; Fluorouracil; Neoplasms; Uracil | 1962 |
Clinical studies with 5-fluorouracil in 47 patients.
Topics: Adenocarcinoma; Adenocarcinoma, Bronchiolo-Alveolar; Carcinoma; Carcinoma, Squamous Cell; Fluorouracil; Humans; Uracil | 1962 |
[A case of multiple liver metastases from colon cancer successfully treated with pharmacokinetic modulating chemotherapy].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colonic Neoplasms; Drug Administration Schedule; Female; Fluorouracil; Hepatic Artery; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Infusions, Intravenous; Liver Neoplasms; Middle Aged; Tegafur; Uracil | 2003 |
[Results of prophylactic hepatic arterial chemotherapy for liver metastases of Dukes C colorectal cancer--correlation with tumoral expression of dihydropyrimidine dehydrogenase, thymidylate synthase, p53, or orotate phosphoribosyl transferase].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Female; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Orotate Phosphoribosyltransferase; Proportional Hazards Models; RNA, Messenger; Tegafur; Thymidylate Synthase; Tumor Suppressor Protein p53; Uracil | 2003 |
[A case of liver and lung metastases of rectal cancer responding well to 5-FU hepato-arterial infusion (HAI) with combined use of oral UFT].
Topics: Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Drug Combinations; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Lung Neoplasms; Male; Rectal Neoplasms; Tegafur; Uracil | 2003 |
[A case of hepatic metastasis and local recurrence from rectal cancer responding to hepatic arterial infusion and systemic chemotherapy].
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Drug Administration Schedule; Drug Combinations; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Irinotecan; Leucovorin; Liver Neoplasms; Male; Neoplasm Recurrence, Local; Rectal Neoplasms; Tegafur; Uracil | 2003 |
[Long-term survival after neck lymph node metastases from sigmoid colon cancer--a case report].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colon, Sigmoid; Combined Modality Therapy; Drug Combinations; Female; Fluorouracil; Humans; Irinotecan; Leucovorin; Lymph Nodes; Lymphatic Metastasis; Neck; Sigmoid Neoplasms; Survivors; Tegafur; Uracil | 2003 |
Modified pharmacokinetic modulating chemotherapy using 5-fluorouracil, UFT, and taxotere (docetaxel) for advanced gastric cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Docetaxel; Fluorouracil; Humans; Infusions, Intravenous; Lymphatic Metastasis; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Staging; Stomach Neoplasms; Taxoids; Tegafur; Treatment Outcome; Uracil | 2003 |
New insights in dihydropyrimidine dehydrogenase deficiency: a pivotal role for beta-aminoisobutyric acid?
Topics: Aminoisobutyric Acids; beta-Alanine; Brain Diseases, Metabolic, Inborn; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Homeostasis; Humans; Inactivation, Metabolic; Neurotransmitter Agents; Purine-Pyrimidine Metabolism, Inborn Errors; Stereoisomerism; Thymine; Uracil; Valine | 2004 |
[Support of TS-1, 5-FU preparation containing potent DPD inhibitor by determination of urinary uracil/serum 5-FU clearance].
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Female; Fluorouracil; Humans; Male; Middle Aged; Oxonic Acid; Pyridines; Stomach Neoplasms; Tegafur; Uracil | 2003 |
[A case of advanced gastric cancer with multiple liver metastases responding completely to hepatic arterial infusion and systemic chemotherapies].
Topics: Adenocarcinoma; Administration, Oral; Adult; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Combined Modality Therapy; Drug Administration Schedule; Drug Combinations; Fluorouracil; Gastrectomy; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Remission Induction; Stomach Neoplasms; Tegafur; Uracil | 2003 |
A novel antimetabolite, TAS-102 retains its effect on FU-related resistant cancer cells.
Topics: Animals; Antimetabolites; Antimetabolites, Antineoplastic; Cell Line, Tumor; Colorectal Neoplasms; Coloring Agents; Drug Combinations; Drug Resistance, Neoplasm; Fluorouracil; Globins; Humans; Liver; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Models, Chemical; Neoplasm Metastasis; Neoplasm Transplantation; Polymerase Chain Reaction; Pyrrolidines; Sensitivity and Specificity; Tetrazolium Salts; Thiazoles; Thymidine Phosphorylase; Thymine; Trifluridine; Uracil | 2004 |
[Assay method for uracil, dihydrouracil, 5-fluorouracil and 5-fluoro-5, 6-dihydrouracil by high-performance liquid chromatography].
Topics: Animals; Chromatography, High Pressure Liquid; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouracil; Humans; Liver; Male; Rats; Uracil | 2004 |
[A case of gastric cancer with a synchronous hepatic metastasis responding to postoperative oral administration of UFT and intermittent intrahepatic arterial chemotherapy of 5-FU].
Topics: Adenocarcinoma; Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Drug Combinations; Fluorouracil; Gastrectomy; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Lymph Node Excision; Male; Neoplasms, Multiple Primary; Remission Induction; Stomach Neoplasms; Tegafur; Uracil | 2004 |
[A case of highly advanced ascending colon cancer with multiple bone and liver metastases and pleuritis carcinomatosa treated with pharmacokinetic modulating chemotherapy and low-dose CPT-11].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Camptothecin; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Fluorouracil; Humans; Irinotecan; Leucovorin; Liver Neoplasms; Male; Middle Aged; Pleurisy; Quality of Life; Tegafur; Uracil | 2004 |
Rapid identification of dihydropyrimidine dehydrogenase deficiency by using a novel 2-13C-uracil breath test.
Topics: Antimetabolites, Antineoplastic; Breath Tests; Carbon Dioxide; Carbon Isotopes; Chromatography, High Pressure Liquid; Diagnostic Tests, Routine; Dihydropyrimidine Dehydrogenase Deficiency; Fluorouracil; Genotype; Humans; Phenotype; Reproducibility of Results; Sensitivity and Specificity; Time Factors; Uracil | 2004 |
Adjuvant chemotherapy for adenocarcinoma of the lung--is the standard of care ready for change?
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Chemotherapy, Adjuvant; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Fluorouracil; Humans; Lung Neoplasms; Prodrugs; Tegafur; Uracil | 2004 |
Embryonic endothelial progenitor cells armed with a suicide gene target hypoxic lung metastases after intravenous delivery.
Topics: Animals; Bone Neoplasms; Bystander Effect; Carcinoma, Lewis Lung; Cell Hypoxia; Cytosine Deaminase; Embryonic and Fetal Development; Endothelium, Vascular; Fluorouracil; Gene Targeting; Genes, Transgenic, Suicide; Genetic Therapy; Genetic Vectors; Injections, Intravenous; Killer Cells, Natural; Lung Neoplasms; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Neovascularization, Pathologic; Osteosarcoma; Pentosyltransferases; Prodrugs; Recombinant Fusion Proteins; Stem Cells; Survival Rate; Uracil; Vascular Endothelial Growth Factor A | 2004 |
[Tumoral dihydropyrimidine dehydrogenase expression and efficacy of 5-fluorouracil plus leucovorin plus UFT therapy in patients with colorectal cancer].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Tegafur; Uracil | 2004 |
A simple and rapid high-performance liquid chromatographic (HPLC) method for 5-fluorouracil (5-FU) assay in plasma and possible detection of patients with impaired dihydropyrimidine dehydrogenase (DPD) activity.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Chromatography, High Pressure Liquid; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouracil; Humans; Middle Aged; Polymorphism, Genetic; Uracil | 2004 |
A novel combination antimetabolite, TAS-102, exhibits antitumor activity in FU-resistant human cancer cells through a mechanism involving FTD incorporation in DNA.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Colonic Neoplasms; DNA Damage; DNA, Neoplasm; Drug Combinations; Drug Resistance, Neoplasm; Floxuridine; Fluorouracil; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Pyrrolidines; Rats; Rats, Nude; Stomach Neoplasms; Thymine; Trifluridine; Uracil; Xenograft Model Antitumor Assays | 2004 |
UPS1 and UPS2 from Arabidopsis mediate high affinity transport of uracil and 5-fluorouracil.
Topics: Allantoin; Animals; Arabidopsis; Arabidopsis Proteins; Biological Transport; DNA; Dose-Response Relationship, Drug; Electrophysiology; Escherichia coli; Fluorouracil; Gene Silencing; Membrane Transport Proteins; Models, Genetic; Mutation; Oocytes; Phenotype; Promoter Regions, Genetic; RNA; RNA Processing, Post-Transcriptional; RNA, Messenger; Substrate Specificity; Up-Regulation; Uracil; Xenopus; Xenopus laevis | 2004 |
DNA ligases ensure fidelity by interrogating minor groove contacts.
Topics: Base Pairing; Binding Sites; DNA; DNA Ligases; Fluorouracil; Guanine; Hydrogen Bonding; Hydrogen-Ion Concentration; Nucleic Acid Conformation; Uracil | 2004 |
[A case of successful management of nonresectable pancreas cancer with liver metastasis by intra-arterial infusion chemotherapy with gemcitabine hydrochloride, 5-FU, CDDP and administration of tegafur/uracil].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Deoxycytidine; Drug Administration Schedule; Drug Combinations; Fluorouracil; Gemcitabine; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Liver Neoplasms; Male; Pancreatic Neoplasms; Quality of Life; Tegafur; Uracil | 2004 |
[A case of successful treatment with combined 5-fluorouracil, adriamycin, cisplatin (FAP) therapy followed by Gemcitabine, UFT therapy and intra-arterial FAP therapy for unresectable advanced gallbladder cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Deoxycytidine; Doxorubicin; Female; Fluorouracil; Gallbladder Neoplasms; Gemcitabine; Humans; Middle Aged; Tegafur; Uracil | 2004 |
[The 5-fluorouracil hepato-arterial infusion with oral UFT therapy for the hepatic and extra hepatic metastases of colorectal cancer].
Topics: Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Administration Schedule; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Tegafur; Uracil | 2004 |
[A case report--Efficacy of combination therapy to unresectable advanced gall bladder carcinoma--palliative operation, hepatic arterial infusion therapy, and radiation therapy].
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Combined Modality Therapy; Drug Combinations; Duodenal Neoplasms; Fluorouracil; Gallbladder Neoplasms; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Mitomycin; Palliative Care; Stents; Tegafur; Uracil | 2004 |
[A case of long-term survivor with multiple pulmonary metastases of HCC after hepatic resection].
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Cisplatin; Drug Combinations; Fluorouracil; Hepatectomy; Humans; Interferon-alpha; Interferon-beta; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Neoplasm Recurrence, Local; Oxonic Acid; Pyridines; Tegafur; Time Factors; Uracil | 2004 |
Immunohistochemical evaluation of thymidylate synthase (TS) and p16INK4a in advanced colorectal cancer: implication of TS expression in 5-FU-based adjuvant chemotherapy.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Chemotherapy, Adjuvant; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p16; Drug Combinations; Female; Fluorouracil; Humans; Immunohistochemistry; Male; Middle Aged; Neoplasm Invasiveness; Postoperative Period; Rectal Neoplasms; Tegafur; Thymidylate Synthase; Uracil | 2004 |
5-(Phenylthio)acyclouridine: a powerful enhancer of oral uridine bioavailability: relevance to chemotherapy with 5-fluorouracil and other uridine rescue regimens.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Biological Availability; Body Weight; Female; Fluorouracil; Mice; Mice, Inbred Strains; Thiouracil; Uracil; Uridine; Uridine Phosphorylase | 2005 |
[A case of liver metastases from cecal cancer successfully treated with fluorouracil and folinic acid (UFT/LV)].
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Cecal Neoplasms; Chemotherapy, Adjuvant; Colectomy; Drug Administration Schedule; Drug Combinations; Fluorouracil; Humans; Leucovorin; Liver Neoplasms; Male; Tegafur; Uracil | 2005 |
[Pharmacokinetic modulating chemotherapy for rectal carcinoma metastases to the liver and lung--a case report].
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Liver Neoplasms; Lung Neoplasms; Rectal Neoplasms; Tegafur; Uracil | 2005 |
[Modified pharmacokinetic modulating chemotherapy for progressive gastric cancer accompanied by peritoneal dissemination].
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Angiotensin II; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Male; Methotrexate; Middle Aged; Peritoneal Neoplasms; Stomach Neoplasms; Survival Rate; Tegafur; Uracil | 2005 |
[A case of advanced gastric cancer with bone metastasis and severe DIC responding to hypertensive subselective chemotherapy with pharmacokinetic modulating chemotherapy].
Topics: Angiotensin II; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Carcinoma, Signet Ring Cell; Disseminated Intravascular Coagulation; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Infusion Pumps, Implantable; Methotrexate; Middle Aged; Paclitaxel; Quality of Life; Stomach Neoplasms; Tegafur; Uracil | 2005 |
Improved analysis of 5-Fluorouracil and 5,6-dihydro-5-Fluorouracil by HPLC with diode array detection for determination of cellular dihydropyrimidine dehydrogenase activity and pharmacokinetic profiling.
Topics: Aged; Antimetabolites, Antineoplastic; Chromatography, High Pressure Liquid; Dihydrouracil Dehydrogenase (NADP); Drug Monitoring; Female; Fluorouracil; Humans; Male; Middle Aged; Uracil | 2005 |
Effects of oral 5-fluorouracil drugs on hepatic fat content in patients with colon cancer.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Chi-Square Distribution; Colonic Neoplasms; Fatty Liver; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Retrospective Studies; Tegafur; Tomography, X-Ray Computed; Uracil | 2005 |
Correlations between antitumor activities of fluoropyrimidines and DPD activity in lung tumor xenografts.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Cell Line, Tumor; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Floxuridine; Fluorouracil; Humans; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Orotate Phosphoribosyltransferase; Oxonic Acid; Pyridines; Tegafur; Thymidine Phosphorylase; Treatment Outcome; Uracil; Xenograft Model Antitumor Assays | 2005 |
Hydrophilic interaction liquid chromatography-APCI-mass spectrometry determination of 5-fluorouracil in plasma and tissues.
Topics: Animals; Antimetabolites; Calibration; Chemical Phenomena; Chemistry, Physical; Chromatography, Liquid; Fluorouracil; Mass Spectrometry; Mice; Reference Standards; Tissue Distribution; Uracil | 2005 |
Leflunomide and peripheral neuropathy: a potential interaction between uracil/tegafur and leflunomide.
Topics: Administration, Oral; Aged; Arthritis, Rheumatoid; Comorbidity; Disease Progression; Drug Administration Schedule; Drug Combinations; Drug Interactions; Drug Therapy, Combination; Fluorouracil; Humans; Isoxazoles; Leflunomide; Male; Peripheral Nervous System Diseases; Polyneuropathies; Rectal Neoplasms; Tegafur; Time Factors; Uracil | 2005 |
New short route to unsaturated fluoroketonucleosides: case of 5-fluoro-1-(6-O-acetyl-3,4-di-deoxy-3-fluoro-beta-D-glycero-hex-3-eno-pyranos-2-ulosyl) uracil.
Topics: Chromatography, Thin Layer; Fluorine; Fluorouracil; Immunosuppressive Agents; Ketones; Magnetic Resonance Spectroscopy; Models, Chemical; Nucleosides; Uracil | 2005 |
An accurate dihydrouracil/uracil determination using improved high performance liquid chromatography method for preventing fluoropyrimidines-related toxicity in clinical practice.
Topics: Chromatography, High Pressure Liquid; Drug-Related Side Effects and Adverse Reactions; Fluorouracil; Humans; Reproducibility of Results; Temperature; Time Factors; Uracil | 2005 |
[Combined chemotherapy with oral leucovorin (LV) + tegafur/uracil (UFT) and hepatic arterial infusion (HAI) therapy for liver metastasis of colorectal cancer].
Topics: Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Male; Middle Aged; Tegafur; Uracil | 2005 |
BiDil raises questions about race as a marker.
Topics: Biomarkers; Black People; Clinical Trials as Topic; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); Drug Approval; Drug Combinations; Drug Interactions; ErbB Receptors; Erlotinib Hydrochloride; Fluorouracil; Gefitinib; Heart Failure; Humans; Hydralazine; Isosorbide; Middle Aged; Mutation; National Institutes of Health (U.S.); Polymorphism, Genetic; Quinazolines; Risk Factors; Socioeconomic Factors; Treatment Outcome; United States; Uracil; White People | 2005 |
Dihydropyrimidine dehydrogenase deficiency presenting at birth.
Topics: Age of Onset; Antimetabolites; Binding Sites; Digestive System Abnormalities; Dihydropyrimidine Dehydrogenase Deficiency; Female; Fluorouracil; Genes, Recessive; Heterozygote; Homozygote; Humans; Infant, Newborn; Muscular Diseases; Mutation; Purine-Pyrimidine Metabolism, Inborn Errors; Thymine; Uracil | 2005 |
[Case report--postoperative continuous intraarterial infusion of small doses of 5-FU successfully controlled residual tumor and liver metastasis of stage IV gastric cancer].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Disease-Free Survival; Doxorubicin; Drug Combinations; Floxuridine; Fluorouracil; Gastrectomy; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Lymph Node Excision; Lymph Nodes; Lymphatic Metastasis; Male; Methotrexate; Mitomycin; Neoplasm Staging; Picibanil; Proteoglycans; Stomach Neoplasms; Tegafur; Uracil | 2005 |
[A case of colon cancer with multiple liver, lung and bone metastases successfully treated with combined weekly high-dose 5-FU (WHF) chemotherapy with UFT and CPT-11].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Camptothecin; Colectomy; Colonic Neoplasms; Combined Modality Therapy; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Irinotecan; Liver Neoplasms; Lung Neoplasms; Middle Aged; Tegafur; Uracil | 2005 |
[Hepatic arterial infusion (HAI) chemotherapy achieved a complete response (CR) for multiple liver metastases of colorectal cancer--two case reports].
Topics: Administration, Oral; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Colorectal Neoplasms; Fluorouracil; Hepatectomy; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Remission Induction; Tegafur; Uracil | 2005 |
Chemotherapy of metastatic colorectal cancer: fluorouracil plus folinic acid and irinotecan or oxaliplatin.
Topics: Antibodies, Monoclonal; Antineoplastic Agents; Camptothecin; Chemotherapy, Adjuvant; Clinical Trials as Topic; Colorectal Neoplasms; Deoxycytidine; Drug Therapy, Combination; Fluorouracil; Humans; Leucovorin; Neoplasm Metastasis; Organoplatinum Compounds; Quinazolines; Tegafur; Thiophenes; Treatment Outcome; Uracil | 2005 |
Linking uracil base excision repair and 5-fluorouracil toxicity in yeast.
Topics: Antimetabolites, Antineoplastic; Cell Cycle; DNA Damage; DNA Repair; DNA, Fungal; Fluorouracil; RNA, Fungal; Saccharomyces cerevisiae; Uracil | 2006 |
Liquid chromatography-tandem mass spectrometric assay for the analysis of uracil, 5,6-dihydrouracil and beta-ureidopropionic acid in urine for the measurement of the activities of the pyrimidine catabolic enzymes.
Topics: beta-Alanine; Biological Assay; Calibration; Capecitabine; Case-Control Studies; Child; Child, Preschool; Chromatography, Liquid; Deoxycytidine; Enzymes; Female; Fluorouracil; Humans; Infant, Newborn; Male; Pyrimidines; Spectrometry, Mass, Electrospray Ionization; Uracil | 2006 |
High-performance liquid chromatographic assay with UV detection for measurement of dihydrouracil/uracil ratio in plasma.
Topics: Chromatography, High Pressure Liquid; Fluorouracil; Humans; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Uracil | 2006 |
Guides for adjuvant treatment of colon cancer. TTD Group (Spanish Cooperative Group for Gastrointestinal Tumor Therapy).
Topics: Adenocarcinoma; Algorithms; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Chemotherapy, Adjuvant; Colorectal Neoplasms; Deoxycytidine; Drug Administration Schedule; Fluorouracil; Humans; Leucovorin; Lymphatic Metastasis; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Randomized Controlled Trials as Topic; Risk Assessment; Tegafur; Uracil | 2006 |
[A case of hepatic metastases of sigmoid colon cancer which completely responded to systemic l-leucovorin/5-FU therapy and oral LV/UFT combination therapy].
Topics: Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Drug Combinations; Fluorouracil; Humans; Leucovorin; Liver Neoplasms; Male; Sigmoid Neoplasms; Tegafur; Uracil | 2006 |
[Second-line chemotherapy with pharmacokinetic modulating chemotherapy for unresectable colorectal carcinoma recurrences resistant to 5-FU-based chemotherapy].
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chronotherapy; Colonic Neoplasms; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Liver Neoplasms; Lung Neoplasms; Lymph Nodes; Lymphatic Metastasis; Male; Middle Aged; Rectal Neoplasms; Survival Rate; Tegafur; Uracil | 2006 |
Retrospective analysis on prognostic impact of adjuvant chemotherapy in the patients with advanced and resectable oral squamous cell carcinoma.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemotherapy, Adjuvant; Cisplatin; Disease-Free Survival; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Lymph Nodes; Lymphatic Metastasis; Male; Middle Aged; Mouth Neoplasms; Neck; Neoadjuvant Therapy; Neoplasm Staging; Prognosis; Proportional Hazards Models; Radiotherapy Dosage; Retrospective Studies; Survival Rate; Tegafur; Uracil | 2006 |
Schedule-dependent therapeutic effects of gemcitabine combined with uracil-tegafur in a human pancreatic cancer xenograft model.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Survival; Deoxycytidine; Drug Administration Schedule; Drug Combinations; Equilibrative Nucleoside Transporter 1; Fluorouracil; Gemcitabine; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Pancreatic Neoplasms; RNA, Messenger; Tegafur; Uracil; Xenograft Model Antitumor Assays | 2006 |
Evaluations of biomarkers associated with 5-FU sensitivity for non-small-cell lung cancer patients postoperatively treated with UFT.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Combined Modality Therapy; Female; Fluorouracil; Humans; Immunohistochemistry; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Survival Analysis; Tegafur; Uracil | 2006 |
[Antitumor activity and function of S-1, a new oral tegafur-based formulation].
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Administration Schedule; Drug Combinations; Fluorouracil; Humans; Mice; Neoplasm Transplantation; Neoplasms; Oxonic Acid; Pharmaceutical Preparations; Rats; Sarcoma, Yoshida; Tegafur; Uracil | 2006 |
[Plasma concentrations of 5-fluorouracil and F-beta-alanine following oral administration of S-1, a dihydropyrimidine dehydrogenase inhibitory fluoropyrimidine, as compared with protracted venous infusion of 5-fluorouracil].
Topics: beta-Alanine; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Fluorouracil; Humans; Infusions, Intravenous; Kidney; Oxonic Acid; Stomach Neoplasms; Tegafur; Uracil | 2006 |
[A case of advanced esophageal cancer with suspected tracheoesophageal fistula that responded to chemoradiotherapy].
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Drug Administration Schedule; Drug Combinations; Esophageal Neoplasms; Fluorouracil; Humans; Male; Middle Aged; Quality of Life; Radiotherapy Dosage; Remission Induction; Stents; Tegafur; Trachea; Tracheal Stenosis; Tracheoesophageal Fistula; Uracil | 2006 |
Michael addition of pyrimidine with disaccharide acrylates catalyzed in organic medium with lipase M from Mucor javanicus.
Topics: Acrylates; Disaccharides; Fluorouracil; Lipase; Mucor; Thymine; Uracil | 2006 |
[A case of effective multidisciplinary treatment with hepatic resection for synchronous multiple liver metastases from rectal cancer].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Doxorubicin; Drug Administration Schedule; Drug Combinations; Fluorouracil; Humans; Liver Neoplasms; Male; Middle Aged; Mitomycin; Quality of Life; Rectal Neoplasms; Remission Induction; Tegafur; Uracil | 2006 |
Identification of a novel mutation in the dihydropyrimidine dehydrogenase gene in a patient with a lethal outcome following 5-fluorouracil administration and the determination of its frequency in a population of 500 patients with colorectal carcinoma.
Topics: Adenine; Aged; Alleles; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); DNA Mutational Analysis; DNA, Complementary; Exons; Fatal Outcome; Female; Fluorouracil; Gene Frequency; Humans; Introns; Mutation; Pedigree; Polymorphism, Single Nucleotide; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Thymine; Uracil | 2007 |
5-Fluorouracil-related severe toxicity: a comparison of different methods for the pretherapeutic detection of dihydropyrimidine dehydrogenase deficiency.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouracil; Genetic Testing; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; RNA, Messenger; Uracil | 2007 |
Catabolism of pyrimidines in yeast: a tool to understand degradation of anticancer drugs.
Topics: Antineoplastic Agents; Drug Screening Assays, Antitumor; Evolution, Molecular; Fluorouracil; Fungal Proteins; Gene Expression Regulation, Fungal; Genes, Fungal; Genome, Fungal; Models, Genetic; Phylogeny; Pyrimidines; Saccharomyces; Time Factors; Uracil | 2006 |
Anticancer nucleobase analogues 6-mercaptopurine and 6-thioguanine are novel substrates for equilibrative nucleoside transporter 2.
Topics: Animals; Antimetabolites, Antineoplastic; Binding, Competitive; Cell Membrane Permeability; Chlorocebus aethiops; COS Cells; Equilibrative-Nucleoside Transporter 2; Fluorouracil; Guanine; Hypoxanthine; Kinetics; Mercaptopurine; Mice; Thioguanine; Transfection; Uracil; Uridine | 2007 |
The Hollow Fibre Assay as a model for in vivo pharmacodynamics of fluoropyrimidines in colon cancer cells.
Topics: Administration, Oral; Animals; Apoptosis; Capecitabine; Cell Cycle; Cell Line, Tumor; Colonic Neoplasms; Deoxycytidine; Drug Combinations; Drug Synergism; Enzyme Inhibitors; Flow Cytometry; Floxuridine; Fluorouracil; Humans; Mice; Mice, Inbred BALB C; Pyrrolidines; Sensitivity and Specificity; Thymidine Phosphorylase; Thymine; Treatment Outcome; Trifluridine; Tumor Cells, Cultured; Uracil; Xenograft Model Antitumor Assays | 2007 |
[Hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma providing a good QOL].
Topics: Aged; alpha-Fetoproteins; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Cisplatin; Epirubicin; Fluorouracil; Hepatectomy; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Quality of Life; Tegafur; Tomography, X-Ray Computed; Uracil | 2006 |
An efficient synthesis of 3-fluoro-5-thio-xylofuranosyl nucleosides of thymine, uracil, and 5-fluorouracil as potential antitumor or/and antiviral agents.
Topics: Antineoplastic Agents; Antiviral Agents; Caco-2 Cells; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Fluorouracil; Humans; Intestines; Microbial Sensitivity Tests; Molecular Structure; Nucleosides; Rotavirus; Stereoisomerism; Structure-Activity Relationship; Thymine; Uracil; Xylose; Zidovudine | 2007 |
[A resected case of squamous cell carcinoma of the breast successfully treated by FU plus cisplatin (CDDP) adjuvant therapy against recurrent metastases].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, Squamous Cell; Chemotherapy, Adjuvant; Cisplatin; Combined Modality Therapy; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Mastectomy; Neoplasm Invasiveness; Oxonic Acid; Skin Neoplasms; Tegafur; Uracil | 2007 |
[A long survival case of sigmoid colon cancer patient with initially unresectable hepatic metastases].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Drug Combinations; Female; Fluorouracil; Hepatectomy; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Middle Aged; Neoadjuvant Therapy; Second-Look Surgery; Sigmoid Neoplasms; Survivors; Tegafur; Uracil | 2007 |
The clinical and economic benefits of capecitabine and tegafur with uracil in metastatic colorectal cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Tegafur; United Kingdom; Uracil | 2007 |
[Comparison the standard therapies of gastric cancer in Japan with those in the West].
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Drug Administration Schedule; Drug Combinations; Europe; Fluorouracil; Gastrectomy; Humans; Japan; Lymph Node Excision; Mitomycin; Neoplasm Staging; Practice Guidelines as Topic; Stomach Neoplasms; Survival Rate; Tegafur; United States; Uracil | 2007 |
Real-time monitoring of uracil removal by uracil-DNA glycosylase using fluorescent resonance energy transfer probes.
Topics: Base Sequence; Catalysis; Cell Line, Tumor; Cell-Free System; Cisplatin; Enzyme Activation; Fluorescence Resonance Energy Transfer; Fluorouracil; Gentamicins; Humans; Kinetics; Models, Biological; Reproducibility of Results; Uracil; Uracil-DNA Glycosidase | 2007 |
Evidence for distinct DNA- and RNA-based mechanisms of 5-fluorouracil cytotoxicity in Saccharomyces cerevisiae.
Topics: Antimetabolites, Antineoplastic; DNA; DNA Repair; Fluorouracil; RNA; Saccharomyces cerevisiae; Uracil; Uridine Monophosphate | 2007 |
[An elderly case of advanced cervical esophageal cancer successfully treated with UFT after chemoradiotherapy with docetaxel/5-FU/CDDP].
Topics: Aged, 80 and over; Ambulatory Care; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Docetaxel; Drug Administration Schedule; Drug Combinations; Esophageal Neoplasms; Female; Fluorouracil; Humans; Lung Neoplasms; Lymph Nodes; Lymphatic Metastasis; Quality of Health Care; Taxoids; Tegafur; Uracil | 2007 |
Epidermal growth factor receptor mutation status and adjuvant chemotherapy with uracil-tegafur for adenocarcinoma of the lung.
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; ErbB Receptors; Female; Fluorouracil; Humans; Lung Neoplasms; Male; Mutation; Retrospective Studies; Survival Rate; Tegafur; Tumor Cells, Cultured; Uracil | 2007 |
[The fourth report from Sapporo Tsukisamu Hospital - chemotherapy and its regimen as second choice for patients with early gastric cancer].
Topics: Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Administration Schedule; Female; Fluorouracil; Humans; Male; Middle Aged; Retrospective Studies; Stomach Neoplasms; Survival Rate; Tegafur; Uracil | 2007 |
[A case of metastatic rectal cancer showing a sustained complete response to chemotherapy with FOLFIRI followed by UFT].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Female; Fluorouracil; Humans; Leucovorin; Neoplasm Metastasis; Rectal Neoplasms; Tegafur; Uracil | 2007 |
Uracil incorporation into genomic DNA does not predict toxicity caused by chemotherapeutic inhibition of thymidylate synthase.
Topics: Blotting, Western; Capecitabine; Cell Cycle; Cell Line; Deoxycytidine; DNA; DNA Primers; DNA Repair; Fluorouracil; Green Fluorescent Proteins; Humans; Mass Spectrometry; Quinazolines; Thiophenes; Thymidylate Synthase; Uracil; Uracil-DNA Glycosidase | 2008 |
Synthesis of FUDP-N-acetylglucosamine and FUDP-glucose in Saccharomyces cerevisiae cells treated with 5-fluorouracil.
Topics: Aerobiosis; Alkaline Phosphatase; Antimetabolites; Chromatography, Liquid; Culture Media; Fermentation; Fluorodeoxyuridylate; Fluorouracil; Magnetic Resonance Spectroscopy; Microbial Viability; Phosphodiesterase I; Saccharomyces cerevisiae; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrum Analysis; Uracil; Uridine Diphosphate Glucose; Uridine Diphosphate Glucose Dehydrogenase; Uridine Diphosphate N-Acetylglucosamine | 2008 |
[A case report--combination chemotherapy with oral UFT and CPT-11, 5-FU, l-LV by hepatic arterial infusion for multiple hepatic metastasis from sigmoid colon cancer].
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Female; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Irinotecan; Leucovorin; Liver Neoplasms; Middle Aged; Sigmoid Neoplasms; Tegafur; Uracil | 2007 |
UFT as maintenance therapy in patients with advanced colorectal cancer responsive to the FOLFOX4 regimen.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Disease Progression; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Organoplatinum Compounds; Quality of Life; Remission Induction; Tegafur; Uracil | 2007 |
Stochastic switching as a survival strategy in fluctuating environments.
Topics: Adaptation, Biological; Bacterial Proteins; Cell Survival; Environment; Fluorouracil; Fungal Proteins; Galactokinase; Galactose; Luminescent Proteins; Models, Biological; Orotic Acid; Phenotype; Promoter Regions, Genetic; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Stochastic Processes; Time Factors; Uracil | 2008 |
5-Fluorouracil incorporated into the tissue RNA of human and rat bladder carcinoma after administration of 1-(2-tetrahydrofuryl)-5-fluorouracil combined with uracil.
Topics: Aged; Aged, 80 and over; Animals; Antineoplastic Combined Chemotherapy Protocols; Drug Combinations; Female; Fluorouracil; Humans; Male; Middle Aged; Rats; Rats, Inbred F344; RNA, Neoplasm; Tegafur; Uracil; Urinary Bladder Neoplasms; Xenograft Model Antitumor Assays | 2008 |
Controlled delivery of 5-chlorouracil using poly(ortho esters) in filtering surgery for glaucoma.
Topics: Animals; Antimitotic Agents; Apoptosis; Blister; Cell Death; Cell Proliferation; Cell Survival; Cells, Cultured; Chromatin; Conjunctiva; Drug Delivery Systems; Female; Fibroblasts; Filtering Surgery; Fluorouracil; Glaucoma; Humans; Immunohistochemistry; Injections; Intraocular Pressure; Necrosis; Polymers; Rabbits; Trabeculectomy; Uracil | 2008 |
The dihydrouracil/uracil ratio in plasma, clinical and genetic analysis for screening of dihydropyrimidine dehydrogenase deficiency in colorectal cancer patients treated with 5-fluorouracil.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Biomarkers; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); DNA; Female; Fluorouracil; Genetic Testing; Half-Life; Homozygote; Humans; Male; Middle Aged; Spectrophotometry, Ultraviolet; Uracil | 2009 |
Bisphosphonates activate the 5-fluorouracil/uracil phosphoribosyltransferase activity present in Saccharomyces cerevisiae cell extracts: implications for tumor treatments.
Topics: Antimetabolites, Antineoplastic; Bone Density Conservation Agents; Diphosphonates; Fluorouracil; Neoplasms; Pentosyltransferases; Saccharomyces cerevisiae; Uracil | 2008 |
Immunochemotherapy with PSK and fluoropyrimidines improves long-term prognosis for curatively resected colorectal cancer.
Topics: Aged; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Combined Modality Therapy; Drug Combinations; Female; Floxuridine; Fluorouracil; Humans; Immunotherapy; Kaplan-Meier Estimate; Male; Middle Aged; Prognosis; Proportional Hazards Models; Proteoglycans; Retrospective Studies; Tegafur; Uracil | 2008 |
[Two cases of squamous cell carcinoma of upper urinary tract with hypercalcemia].
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Combined Modality Therapy; Fatal Outcome; Female; Fluorouracil; Granulocyte Colony-Stimulating Factor; Humans; Hypercalcemia; Kidney Neoplasms; Kidney Pelvis; Male; Middle Aged; Neoplasm Recurrence, Local; Parathyroid Hormone-Related Protein; Radiotherapy; Tegafur; Uracil; Ureteral Neoplasms | 2008 |
[A case of metastatic lung and liver tumors from rectal cancer treated with oral UFT and CPT-11 by hepatic arterial infusion followed by FOLFOX and FOLFIRI].
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Camptothecin; Fluorouracil; Humans; Infusions, Intra-Arterial; Irinotecan; Leucovorin; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Organoplatinum Compounds; Rectal Neoplasms; Tegafur; Tomography, X-Ray Computed; Uracil | 2008 |
Imprinted hydrophilic nanospheres as drug delivery systems for 5-fluorouracil sustained release.
Topics: Acetonitriles; Antimetabolites, Antineoplastic; Cross-Linking Reagents; Delayed-Action Preparations; Drug Delivery Systems; Ethylene Glycol; Fluorouracil; Hydrogel, Polyethylene Glycol Dimethacrylate; Methacrylates; Microscopy, Electron, Scanning; Molecular Imprinting; Molecular Structure; Nanoparticles; Nanospheres; Nanotechnology; Polymers; Technology, Pharmaceutical; Uracil; Water | 2009 |
Gemcitabine-based versus fluoropyrimidine-based chemotherapy with or without platinum in unresectable biliary tract cancer: a retrospective study.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Biliary Tract Neoplasms; Capecitabine; Cisplatin; Deoxycytidine; Drug Combinations; Female; Fluorouracil; Gemcitabine; Humans; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Oxonic Acid; Palliative Care; Pyrimidinones; Retrospective Studies; Tegafur; Treatment Outcome; Uracil | 2008 |
The efficacy and safety of concurrent chemoradiotherapy for maxillary sinus squamous cell carcinoma patients.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Squamous Cell; Cisplatin; Combined Modality Therapy; Female; Fluorouracil; Humans; Kaplan-Meier Estimate; Leucovorin; Male; Maxillary Sinus; Methotrexate; Middle Aged; Neoadjuvant Therapy; Organ Preservation; Paranasal Sinus Neoplasms; Retrospective Studies; Tegafur; Treatment Outcome; Uracil | 2009 |
Ultratrace analysis of uracil and 5-fluorouracil by molecularly imprinted polymer brushes grafted to silylated solid-phase microextraction fiber in combination with complementary molecularly imprinted polymer-based sensor.
Topics: Benzenesulfonates; Binding Sites; Dihydropyrimidine Dehydrogenase Deficiency; Fluorouracil; Humans; Microscopy, Electron, Scanning; Molecular Imprinting; Polymers; Sensitivity and Specificity; Solid Phase Microextraction; Solvents; Spectroscopy, Fourier Transform Infrared; Surface Properties; Uracil | 2009 |
Pharmacokinetic study of S-1.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Administration, Oral; Anti-Ulcer Agents; Antimetabolites, Antineoplastic; Area Under Curve; beta-Alanine; Biological Availability; Clinical Trials as Topic; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Fasting; Fluorouracil; Food; Gastric Acidity Determination; Half-Life; Humans; Hydrogen-Ion Concentration; Oxonic Acid; Pantoprazole; Pyridines; Tegafur; Triazines; Uracil | 2009 |
Vascular endothelial growth factor receptor expression as a prognostic marker for survival in colorectal cancer.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Combinations; Female; Fluorouracil; Humans; Immunoenzyme Techniques; Leucovorin; Male; Middle Aged; Neoplasm Staging; Oxonic Acid; Prognosis; Retrospective Studies; Survival Rate; Tegafur; Uracil; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2; Vascular Endothelial Growth Factor Receptor-3 | 2009 |
Postoperative chemotherapy after neoadjuvant chemoradiation and surgery for rectal cancer: is it essential for patients with ypT0-2N0?
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Floxuridine; Fluorouracil; Follow-Up Studies; Humans; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Recurrence, Local; Rectal Neoplasms; Retrospective Studies; Tegafur; Uracil | 2009 |
The effect of neoadjuvant therapy on the 5-fluorouracil metabolic and relative enzymes of oral squamous cell carcinoma.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouracil; Humans; Male; Middle Aged; Mouth Neoplasms; Neoadjuvant Therapy; Orotate Phosphoribosyltransferase; Tegafur; Thymidine Phosphorylase; Thymidylate Synthase; Uracil | 2009 |
An evaluation of the chick cardiomyocyte micromass system for identification of teratogens in a blind trial.
Topics: Acetone; alpha-Chlorohydrin; Animal Testing Alternatives; Animals; Cell Count; Cell Culture Techniques; Cell Differentiation; Cell Separation; Cell Survival; Cells, Cultured; Chick Embryo; Culture Media; Dose-Response Relationship, Drug; Embryo, Nonmammalian; Embryonic Stem Cells; Ethionine; Fluorouracil; Indicators and Reagents; Methionine; Myocardial Contraction; Myocytes, Cardiac; Neutral Red; Organic Chemicals; Oxazines; Sulfanilamide; Sulfanilamides; Sulfisoxazole; Teratogens; Time Factors; Toxicity Tests; Uracil; Xanthenes | 2009 |
A new, validated HPLC-MS/MS method for the simultaneous determination of the anti-cancer agent capecitabine and its metabolites: 5'-deoxy-5-fluorocytidine, 5'-deoxy-5-fluorouridine, 5-fluorouracil and 5-fluorodihydrouracil, in human plasma.
Topics: 1-Propanol; Acetonitriles; Antimetabolites, Antineoplastic; Capecitabine; Chemical Precipitation; Chromatography, High Pressure Liquid; Deoxycytidine; Drug Stability; Floxuridine; Fluorouracil; Furans; Humans; Linear Models; Pyrimidines; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Trichloroacetic Acid; Uracil; Vidarabine | 2010 |
Correlation of CD133, OCT4, and SOX2 in rectal cancer and their association with distant recurrence after chemoradiotherapy.
Topics: AC133 Antigen; Adult; Aged; Antigens, CD; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Colonic Neoplasms; Combined Modality Therapy; Female; Fluorouracil; Glycoproteins; Humans; Immunoenzyme Techniques; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Neoplasm, Residual; Octamer Transcription Factor-3; Peptides; Prognosis; Radiotherapy Dosage; Rectal Neoplasms; Retrospective Studies; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; SOXB1 Transcription Factors; Survival Rate; Tegafur; Tumor Cells, Cultured; Uracil | 2009 |
The necessity of chemotherapy in T3N0M0 colon cancer without risk factors.
Topics: Adult; Aged; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Colonic Neoplasms; Combined Modality Therapy; Deoxycytidine; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Proportional Hazards Models; Retrospective Studies; Risk Factors; Survival Rate; Tegafur; Treatment Outcome; Uracil | 2009 |
[A case of simultaneous bilateral metastatic ovarian tumor of colon cancer followed by FOLFOX4 Regimen and oral tegafur/uracil+oral leucovorin after R0 operation].
Topics: Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colectomy; Colonic Neoplasms; Female; Fluorouracil; Humans; Leucovorin; Organoplatinum Compounds; Ovarian Neoplasms; Tegafur; Uracil; Vitamin B Complex | 2009 |
Quantum dynamics of the ultrafast pi pi*/n pi* population transfer in uracil and 5-fluoro-uracil in water and acetonitrile.
Topics: Acetonitriles; Electrons; Fluorouracil; Quantum Theory; Thermodynamics; Uracil; Water | 2009 |
A retrospective comparison of concurrent 5-fluorouracil or oral UFT in postoperative chemoradiation for gastric adenocarcinoma.
Topics: Adenocarcinoma; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Fluorouracil; Gastrectomy; Humans; Male; Middle Aged; Radiotherapy, Adjuvant; Retrospective Studies; Stomach Neoplasms; Tegafur; Uracil | 2010 |
[A Case of gastric endocrine cell carcinoma successfully treated by FU plus irinotecan(CPT-11)adjuvant therapy against recurrent metastases].
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemotherapy, Adjuvant; Fluorouracil; Gastrectomy; Humans; Irinotecan; Lymph Node Excision; Male; Neoplasm Metastasis; Stomach Neoplasms; Tegafur; Uracil | 2009 |
Synthesis of 4,6-dideoxy-3-fluoro-2-keto-beta-D-glucopyranosyl analogues of 5-fluorouracil, N6-benzoyl adenine, uracil, thymine, N4-benzoyl cytosine and evaluation of their antitumor activities.
Topics: Adenine; Animals; Antineoplastic Agents; Cell Line, Tumor; Cytosine; Drug Screening Assays, Antitumor; Fluorouracil; HeLa Cells; Humans; Mice; Nucleosides; Stereoisomerism; Thymine; Uracil | 2010 |
Arabidopsis uracil DNA glycosylase (UNG) is required for base excision repair of uracil and increases plant sensitivity to 5-fluorouracil.
Topics: Amino Acid Sequence; Antimetabolites; Arabidopsis; Arabidopsis Proteins; DNA Repair; Fluorouracil; Humans; Molecular Sequence Data; Molecular Structure; Mutagenesis, Site-Directed; Plants, Genetically Modified; Sequence Alignment; Substrate Specificity; Uracil; Uracil-DNA Glycosidase | 2010 |
A possible cause and remedy for the clinical failure of 5-fluorouracil plus eniluracil.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Fluorouracil; Neoplasms, Experimental; Rats; Rats, Inbred F344; Uracil | 2010 |
Characterization of a novel lymph node metastasis model from human colonic cancer and its preclinical use for comparison of anti-metastatic efficacy between oral S-1 and UFT/ LV.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Colonic Neoplasms; Drug Combinations; Drug Evaluation, Preclinical; Fluorouracil; Humans; Leucovorin; Lymphatic Metastasis; Male; Mice; Middle Aged; Oxonic Acid; Tegafur; Uracil; Xenograft Model Antitumor Assays | 2010 |
Circulating lymphocyte number has a positive association with tumor response in neoadjuvant chemoradiotherapy for advanced rectal cancer.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Combined Modality Therapy; Drug Combinations; Female; Fluorouracil; Follow-Up Studies; Humans; Leucovorin; Lymphocyte Count; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Staging; Oxonic Acid; Radiotherapy, Adjuvant; Rectal Neoplasms; Retrospective Studies; Survival Rate; Tegafur; Treatment Outcome; Uracil | 2010 |
Lethal outcome of 5-fluorouracil infusion in a patient with a total DPD deficiency and a double DPYD and UTG1A1 gene mutation.
Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Colonic Neoplasms; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); Fatal Outcome; Fluorouracil; Humans; Infusion Pumps; Liver Neoplasms; Male; Mutation; Phenotype; Uracil | 2010 |
Oral fluoropyrimidine may augment the efficacy of aromatase inhibitor via the down-regulation of estrogen receptor in estrogen-responsive breast cancer xenografts.
Topics: Anastrozole; Animals; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Blotting, Western; Breast Neoplasms; Cell Proliferation; Doxorubicin; Drug Combinations; Estrogen Receptor alpha; Estrogens; Female; Fluorouracil; Humans; Immunoenzyme Techniques; Mice; Mice, Inbred BALB C; Mice, Nude; Nitriles; Oxonic Acid; Paclitaxel; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tegafur; Transplantation, Heterologous; Triazoles; Tumor Cells, Cultured; Uracil | 2011 |
Determination of eniluracil and 5-fluorouracil in human plasma by LC-MS/MS.
Topics: Chromatography, High Pressure Liquid; Enzyme Inhibitors; Fluorouracil; Humans; Mass Spectrometry; Reproducibility of Results; Sensitivity and Specificity; Uracil | 2010 |
Efficient synthesis of exomethylene- and keto-exomethylene-d-glucopyranosyl nucleoside analogs as potential cytotoxic agents.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cytotoxins; Fluorouracil; Humans; Inhibitory Concentration 50; Mice; Nucleosides; Thymine; Uracil | 2011 |
Combined chemoradiotherapy for early glottic cancer in clinical practice in Japan: analysis of 10 institutions.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cisplatin; Combined Modality Therapy; Dose Fractionation, Radiation; Female; Fluorouracil; Glottis; Humans; Japan; Laryngeal Neoplasms; Male; Middle Aged; Tegafur; Uracil | 2010 |
Dynamics of uracil and 5-fluorouracil in DNA.
Topics: Base Pairing; DNA; DNA Damage; DNA Repair; Fluorouracil; Humans; Kinetics; Thermodynamics; Uracil | 2011 |
Effect of the thymidylate synthase inhibitors on dUTP and TTP pool levels and the activities of DNA repair glycosylases on uracil and 5-fluorouracil in DNA.
Topics: Animals; Cell Line; Chickens; Deoxyuracil Nucleotides; DNA; DNA Damage; DNA Glycosylases; DNA Repair; Enzyme Inhibitors; Fluorouracil; HeLa Cells; Humans; Kinetics; Mice; Thymidylate Synthase; Thymine Nucleotides; Uracil | 2011 |
[A long-term survival case of rectal cancer with Virchow's lymph node metastasis by multimodality therapy].
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Combined Modality Therapy; Fluorouracil; Humans; Irinotecan; Leucovorin; Lymph Nodes; Lymphatic Metastasis; Male; Middle Aged; Organoplatinum Compounds; Rectal Neoplasms; Tegafur; Uracil | 2010 |
[A case of recurrent sigmoid colon cancer with adrenal and para-aortic lymph node metastasis successfully treated by operation and chemotherapy].
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Aorta; Bevacizumab; Camptothecin; Combined Modality Therapy; Female; Fluorouracil; Hepatectomy; Humans; Irinotecan; Leucovorin; Liver Neoplasms; Lymphatic Metastasis; Middle Aged; Neoplasm Recurrence, Local; Organoplatinum Compounds; Sigmoid Neoplasms; Tegafur; Uracil | 2010 |
Uracil influences quorum sensing and biofilm formation in Pseudomonas aeruginosa and fluorouracil is an antagonist.
Topics: Bacterial Proteins; Biofilms; Down-Regulation; Fluorouracil; Gene Expression Regulation, Bacterial; Hordeum; Plant Diseases; Pseudomonas aeruginosa; Quorum Sensing; Regulon; Uracil; Virulence | 2009 |
The achievement of mass balance by simultaneous quantification of floxuridine prodrug, floxuridine, 5-fluorouracil, 5-dihydrouracil, α-fluoro-β-ureidopropionate, α-fluoro-β-alanine using LC-MS.
Topics: Analysis of Variance; Antimetabolites, Antineoplastic; beta-Alanine; Cell Extracts; Cell Line, Tumor; Chromatography, High Pressure Liquid; Floxuridine; Fluorouracil; Humans; Linear Models; Mass Spectrometry; Reproducibility of Results; Uracil; Urea | 2011 |
5-FU-induced neurotoxicity in cancer patients with profound DPD deficiency syndrome: a report of two cases.
Topics: Aged; Antimetabolites, Antineoplastic; Brain; Dihydropyrimidine Dehydrogenase Deficiency; Electroencephalography; Epilepsy, Frontal Lobe; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasms; Neurotoxicity Syndromes; Recovery of Function; Sigmoid Neoplasms; Tomography, X-Ray Computed; Uracil | 2011 |
Adjuvant radio-chemotherapy after extended or simple cholecystectomy in gallbladder cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; Capecitabine; Chemotherapy, Adjuvant; Cholecystectomy; Combined Modality Therapy; Deoxycytidine; Female; Fluorouracil; Follow-Up Studies; Gallbladder Neoplasms; Gemcitabine; Humans; Male; Middle Aged; Radiotherapy, Adjuvant; Survival Rate; Tegafur; Treatment Outcome; Uracil | 2011 |
Plastid uridine salvage activity is required for photoassimilate allocation and partitioning in Arabidopsis.
Topics: Arabidopsis; Arabidopsis Proteins; Biomass; Cellulose; Fluorouracil; Isoenzymes; Light; Lignin; Mutagenesis, Insertional; Orotic Acid; Pentosyltransferases; Phenotype; Plant Leaves; Plants, Genetically Modified; Plastids; Recombinant Fusion Proteins; Seeds; Starch; Uracil; Uridine; Uridine Kinase | 2011 |
Pretherapeutic uracil and dihydrouracil levels of colorectal cancer patients are associated with sex and toxic side effects during adjuvant 5-fluorouracil-based chemotherapy.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colorectal Neoplasms; Diarrhea; Dihydropyrimidine Dehydrogenase Deficiency; Female; Fluorouracil; Humans; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Sex Characteristics; Thrombocytopenia; Uracil | 2012 |
Electron transfer processes in potassium collisions with 5-fluorouracil and 5-chlorouracil.
Topics: Cations; Electron Transport; Fluorouracil; Potassium; Thermodynamics; Uracil | 2011 |
Nonradiative deactivation mechanisms of uracil, thymine, and 5-fluorouracil: a comparative ab initio study.
Topics: Fluorouracil; Molecular Structure; Photochemical Processes; Quantum Theory; Solutions; Thermodynamics; Thymine; Ultraviolet Rays; Uracil | 2012 |
Reliability of tumor primary cultures as a model for drug response prediction: expression profiles comparison of tissues versus primary cultures from colorectal cancer patients.
Topics: Adenocarcinoma; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Cisplatin; Colorectal Neoplasms; Deoxycytidine; Down-Regulation; Doxorubicin; Etoposide; Floxuridine; Fluorescent Antibody Technique; Fluorouracil; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genomic Instability; Humans; Irinotecan; Metaphase; Paclitaxel; Polymerase Chain Reaction; Predictive Value of Tests; Protein Array Analysis; Reproducibility of Results; Tegafur; Tissue Array Analysis; Tumor Cells, Cultured; Up-Regulation; Uracil | 2012 |
A rapid HPLC-ESI-MS/MS method for determination of dihydrouracil/uracil ratio in plasma: evaluation of toxicity to 5-flurouracil in patients with gastrointestinal cancer.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Chromatography, High Pressure Liquid; Female; Fluorouracil; Gastrointestinal Neoplasms; Humans; Male; Middle Aged; Molecular Structure; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Uracil | 2012 |
A spectroscopic investigations of anticancer drugs binding to bovine serum albumin.
Topics: Animals; Antineoplastic Agents; Binding Sites; Cattle; Fluorouracil; Kinetics; Magnetic Resonance Spectroscopy; Protein Binding; Serum Albumin, Bovine; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Temperature; Time Factors; Uracil | 2012 |
LC-MS/MS method for simultaneous analysis of uracil, 5,6-dihydrouracil, 5-fluorouracil and 5-fluoro-5,6-dihydrouracil in human plasma for therapeutic drug monitoring and toxicity prediction in cancer patients.
Topics: Aged; Antimetabolites, Antineoplastic; Chromatography, Liquid; Colorectal Neoplasms; Drug Monitoring; Drug Stability; Female; Fluorouracil; Humans; Linear Models; Male; Middle Aged; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Uracil | 2013 |
Discovery of highly potent human deoxyuridine triphosphatase inhibitors based on the conformation restriction strategy.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Cell Line, Tumor; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Drug Synergism; Fluorouracil; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Models, Molecular; Molecular Conformation; Pyrophosphatases; Stereoisomerism; Structure-Activity Relationship; Sulfonamides; Transplantation, Heterologous; Uracil | 2012 |
Multi-institutional analysis of early glottic cancer from 2000 to 2005.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Squamous Cell; Chemoradiotherapy; Cisplatin; Docetaxel; Female; Fluorouracil; Follow-Up Studies; Glottis; Humans; Laryngeal Neoplasms; Male; Middle Aged; Neoplasm Staging; Prognosis; Survival Rate; Taxoids; Tegafur; Time Factors; Uracil | 2012 |
Early prediction of histopathological response of rectal tumors after one week of preoperative radiochemotherapy using 18 F-FDG PET-CT imaging. A prospective clinical study.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Chemoradiotherapy; Deoxycytidine; Female; Fluorodeoxyglucose F18; Fluorouracil; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Multimodal Imaging; Neoplasm Staging; Positron-Emission Tomography; Preoperative Care; Prognosis; Prospective Studies; Radiopharmaceuticals; Radiotherapy Dosage; Rectal Neoplasms; Tegafur; Tomography, X-Ray Computed; Uracil | 2012 |
Stereocontrolled synthesis of 4'-C-cyano and 4'-C-cyano-4'-deoxy pyrimidine pyranonucleosides as potential chemotherapeutic agents.
Topics: Acetylation; Antineoplastic Agents; Cytostatic Agents; Drug Design; Fluorouracil; HeLa Cells; Humans; Inhibitory Concentration 50; Mannose; Nitriles; Oxidation-Reduction; Oxygen; Pyrimidine Nucleosides; Sodium Cyanide; Stereoisomerism; Thymine; Uracil | 2012 |
Pyrimidine salvage in Trypanosoma brucei bloodstream forms and the trypanocidal action of halogenated pyrimidines.
Topics: Biological Transport; Fluorouracil; Genome-Wide Association Study; Glycosylation; Nucleoside Transport Proteins; Pyrimidines; Trypanosoma brucei brucei; Uracil; Uridine | 2013 |
[Pharmacokinetics of S-1 capsule in patients with advanced gastric cancer].
Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Capsules; Drug Combinations; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Staging; Oxonic Acid; Pyridines; Stomach Neoplasms; Tegafur; Uracil | 2012 |
The prognostic nutritional index predicts long-term outcomes of gastric cancer patients independent of tumor stage.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoembryonic Antigen; Chemotherapy, Adjuvant; Cisplatin; Deoxycytidine; Disease-Free Survival; Drug Combinations; Female; Fluorouracil; Gastrectomy; Humans; Lymphatic Metastasis; Lymphocyte Count; Male; Middle Aged; Nutritional Status; Oxonic Acid; Predictive Value of Tests; Retrospective Studies; Serum Albumin; Stomach Neoplasms; Tegafur; Time Factors; Uracil; Young Adult | 2013 |
Low-temperature NMR studies on the geometry of base pairs involving 5-substituted uracil derivatives.
Topics: Adenosine; Base Pairing; Bromouracil; Cold Temperature; Fluorouracil; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Nitrogen Isotopes; Thymidine; Uracil; Uridine | 2013 |
Genetic polymorphisms of enzymes related to oral tegafur/uracil therapeutic efficacy in patients with hepatocellular carcinoma.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Aryl Hydrocarbon Hydroxylases; Asian People; Carcinoma, Hepatocellular; Cytochrome P-450 CYP2A6; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouracil; Genotype; Hepatitis C; Humans; Japan; Liver Neoplasms; Male; Minisatellite Repeats; Polymorphism, Genetic; Tegafur; Thymidylate Synthase; Uracil | 2013 |
Pre-therapeutic assessment of plasma dihydrouracil/uracil ratio for predicting the pharmacokinetic parameters of 5-fluorouracil and tumor growth in a rat model of colorectal cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Liver; Male; Rats; Rats, Wistar; Tumor Burden; Uracil | 2013 |
Pharmacokinetic/pharmacodynamic modeling of 5-fluorouracil by using a biomarker to predict tumor growth in a rat model of colorectal cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Biomarkers, Tumor; Colon; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Male; Models, Biological; Rats; Rats, Wistar; Rectum; Uracil | 2013 |
A predictive biomarker for altered 5-fluorouracil pharmacokinetics following repeated administration in a rat model of colorectal cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Biomarkers, Tumor; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Liver; Male; Rats; Rats, Wistar; Uracil | 2013 |
Trypanosoma brucei (UMP synthase null mutants) are avirulent in mice, but recover virulence upon prolonged culture in vitro while retaining pyrimidine auxotrophy.
Topics: Amides; Animals; Biological Transport; Cell Line; Deoxyuridine; Fluorouracil; Gene Knockout Techniques; Mice; Multienzyme Complexes; Orotate Phosphoribosyltransferase; Orotic Acid; Orotidine-5'-Phosphate Decarboxylase; Pyrazoles; Pyrimidines; Ribonucleosides; Ribose; Transfection; Trypanocidal Agents; Trypanosoma brucei brucei; Uracil; Uridine; Uridine Monophosphate; Virulence | 2013 |
Substrate inhibition of uracil phosphoribosyltransferase by uracil can account for the uracil growth sensitivity of Leishmania donovani pyrimidine auxotrophs.
Topics: Cations, Divalent; Chromatography, Gel; Enzyme Stability; Feedback, Physiological; Fluorouracil; Hydrogen-Ion Concentration; Kinetics; Leishmania donovani; Mutation; Pentosyltransferases; Phosphoribosyl Pyrophosphate; Protein Multimerization; Protozoan Proteins; Pyrimidines; Recombinant Proteins; Spectrophotometry; Substrate Specificity; Temperature; Thiouracil; Uracil | 2013 |
Indirect assessment of dihydropyrimidine dehydrogenase activity in cats.
Topics: Aging; Animals; Antimetabolites, Antineoplastic; Cat Diseases; Cats; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouracil; Gene Expression Regulation, Enzymologic; Male; Uracil | 2013 |
(13)C-uracil breath test to predict 5-fluorouracil toxicity in gastrointestinal cancer patients.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Breath Tests; Carbon Isotopes; Dihydropyrimidine Dehydrogenase Deficiency; Female; Fluorouracil; Gastrointestinal Neoplasms; Humans; Male; Middle Aged; Mutation; Sensitivity and Specificity; Severity of Illness Index; Uracil | 2013 |
C-reactive protein as predictor of recurrence in patients with rectal cancer undergoing chemoradiotherapy followed by surgery.
Topics: Adenocarcinoma, Mucinous; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; C-Reactive Protein; Carcinoembryonic Antigen; Carcinoma, Signet Ring Cell; Chemoradiotherapy; Combined Modality Therapy; Female; Fluorouracil; Follow-Up Studies; Humans; Lymphocytes; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Staging; Neutrophils; Prognosis; Rectal Neoplasms; Survival Rate; Tegafur; Uracil | 2013 |
New insights into the RNA-based mechanism of action of the anticancer drug 5'-fluorouracil in eukaryotic cells.
Topics: Antimetabolites, Antineoplastic; Fluorouracil; Humans; Molecular Sequence Annotation; RNA Precursors; RNA Processing, Post-Transcriptional; RNA Splicing; RNA, Messenger; RNA, Ribosomal; RNA, Transfer; Schizosaccharomyces; Transcription, Genetic; Uracil | 2013 |
Shape resonance spectra of uracil, 5-fluorouracil, and 5-chlorouracil.
Topics: Electrons; Fluorouracil; Models, Molecular; Uracil | 2014 |
Metronomic adjuvant chemotherapy improves treatment outcome in nasopharyngeal carcinoma patients with postradiation persistently detectable plasma Epstein-Barr virus deoxyribonucleic acid.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Chemotherapy, Adjuvant; Cisplatin; DNA, Viral; Drug Combinations; Epirubicin; Female; Fluorouracil; Herpesvirus 4, Human; Humans; Induction Chemotherapy; Leucovorin; Male; Middle Aged; Mitomycin; Nasopharyngeal Neoplasms; Neoplasm Recurrence, Local; Radiotherapy, Conformal; Retrospective Studies; Tegafur; Treatment Outcome; Uracil | 2014 |
[A retrospective study of tegafur/uracil compared with cyclophosphamide, methotrexate, and fluorouracil as adjuvant chemotherapy in patients with node-negative, triple-negative breast cancer].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cyclophosphamide; Fluorouracil; Humans; Lymphatic Metastasis; Methotrexate; Middle Aged; Recurrence; Retrospective Studies; Tegafur; Triple Negative Breast Neoplasms; Uracil | 2014 |
Deletion of the uracil permease gene confers cross-resistance to 5-fluorouracil and azoles in Candida lusitaniae and highlights antagonistic interaction between fluorinated nucleotides and fluconazole.
Topics: Antifungal Agents; Azoles; Biological Transport; Candida; Crosses, Genetic; Drug Antagonism; Drug Resistance, Fungal; Flucytosine; Fluorouracil; Fungal Proteins; Gene Deletion; Gene Expression Regulation, Fungal; Microbial Sensitivity Tests; Nucleobase Transport Proteins; Nucleotide Transport Proteins; Sterol 14-Demethylase; Uracil; Uridine | 2014 |
Inferior oncological prognosis of surgery without oral chemotherapy for stage III colon cancer in clinical settings.
Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Colectomy; Colonic Neoplasms; Combined Modality Therapy; Deoxycytidine; Female; Fluorouracil; Follow-Up Studies; Humans; Leucovorin; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Neoplasm Staging; Prognosis; Retrospective Studies; Survival Rate; Tegafur; Uracil; Young Adult | 2014 |
Hydrolytic pathway of 5-fluorouracil in aqueous solutions for clinical use.
Topics: Chemistry, Pharmaceutical; Fluorouracil; Hydrogen-Ion Concentration; Hydrolysis; Magnetic Resonance Spectroscopy; Sodium Hydroxide; Solutions; Uracil | 2014 |
β-l-1-[5-(E-2-bromovinyl)-2-(hydroxymethyl)-1,3-(dioxolan-4-yl)] uracil (l-BHDU) prevents varicella-zoster virus replication in a SCID-Hu mouse model and does not interfere with 5-fluorouracil catabolism.
Topics: Acyclovir; Animals; Antiviral Agents; Bromodeoxyuridine; Cell Line; Chickenpox; Dioxolanes; Drug Therapy, Combination; Fluorouracil; Foscarnet; Herpes Zoster; Herpesvirus 3, Human; Humans; Mice; Mice, Inbred BALB C; Mice, SCID; Nucleosides; Organ Culture Techniques; Skin; Uracil; Virus Replication | 2014 |
The effect of Pot1 binding on the repair of thymine analogs in a telomeric DNA sequence.
Topics: Base Sequence; Binding Sites; DNA; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase; Fluorouracil; Pentoxyl; Protein Binding; Schizosaccharomyces pombe Proteins; Shelterin Complex; Telomere; Telomere-Binding Proteins; Uracil; Uracil-DNA Glycosidase | 2014 |
Short oligonucleotide prodrug having 5-fluoro and 5-iodouracil inhibits the proliferation of cancer cells in a photo-responsive manner.
Topics: Antineoplastic Agents; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Fluorouracil; HeLa Cells; Humans; Molecular Structure; Oligonucleotides; Photochemical Processes; Prodrugs; Structure-Activity Relationship; Uracil | 2014 |
Pretherapeutic uracil and dihydrouracil levels in saliva of colorectal cancer patients are associated with toxicity during adjuvant 5-fluorouracil-based chemotherapy.
Topics: Aged; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Drug-Related Side Effects and Adverse Reactions; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Staging; Predictive Value of Tests; Reproducibility of Results; Risk Assessment; Saliva; Sex Factors; Uracil | 2014 |
Predicting 5-fluorouracil toxicity: DPD genotype and 5,6-dihydrouracil:uracil ratio.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouracil; Genotype; Humans; Male; Middle Aged; Uracil | 2014 |
Multicenter observational cohort study of post-operative treatment for completely resected non-small-cell lung cancer of pathological Stage I (T1 >2 cm and T2 in TNM classification version 6).
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Chemotherapy, Adjuvant; Cohort Studies; Disease-Free Survival; Drug Combinations; Female; Fluorouracil; Humans; Kaplan-Meier Estimate; Lung Neoplasms; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Oxonic Acid; Patient Selection; Postoperative Period; Prodrugs; Proportional Hazards Models; Tegafur; Uracil | 2015 |
Efficacy of combination chemotherapy using a novel oral chemotherapeutic agent, TAS-102, with irinotecan hydrochloride on human colorectal and gastric cancer xenografts.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Line, Tumor; Colorectal Neoplasms; Drug Combinations; Fluorouracil; Humans; Irinotecan; Male; Mice; Pyrrolidines; Stomach Neoplasms; Thymine; Trifluridine; Uracil; Xenograft Model Antitumor Assays | 2015 |
Simulation of the resonance Raman spectra for 5-halogenated (F, Cl, and Br) uracils.
Topics: Bromouracil; Fluorouracil; Molecular Structure; Quantum Theory; Spectrum Analysis, Raman; Uracil | 2015 |
Crucial roles of thymidine kinase 1 and deoxyUTPase in incorporating the antineoplastic nucleosides trifluridine and 2'-deoxy-5-fluorouridine into DNA.
Topics: Antimetabolites, Antineoplastic; Colorectal Neoplasms; DNA, Neoplasm; Drug Combinations; Equilibrative Nucleoside Transporter 1; Equilibrative-Nucleoside Transporter 2; Fluorouracil; HCT116 Cells; Humans; Male; Pyrophosphatases; Pyrrolidines; Substrate Specificity; Thymidine Kinase; Thymine; Trifluridine; Uracil | 2015 |
Influence of metastatic disease on the usefulness of uracil pharmacokinetics as a screening tool for DPD activity in colorectal cancer patients.
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Humans; Neoplasm Metastasis; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Uracil | 2015 |
Differential nucleobase protection against 5-fluorouracil toxicity for squamous and columnar cells: implication for tissue function and oncogenesis.
Topics: Adenine; Carcinogenesis; Cell Line, Tumor; DNA Replication; Epithelial Cells; Esophagus; Fluorouracil; Gastric Mucosa; Gene Expression; Humans; Nucleobase Transport Proteins; Protective Agents; Pyrimidines; RNA, Messenger; Uracil | 2015 |
Genotyping of a family with a novel deleterious DPYD mutation supports the pretherapeutic screening of DPD deficiency with dihydrouracil/uracil ratio.
Topics: Adult; Antimetabolites, Antineoplastic; Biotransformation; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); DNA; Family; Fatal Outcome; Female; Fluorouracil; Gene Duplication; Genetic Variation; Genotype; Heterozygote; Humans; Male; Middle Aged; Mutation; Phenotype; Retrospective Studies; Uracil | 2016 |
Cell Lysis in S. pombe ura4 Mutants Is Suppressed by Loss of Functional Pub1, Which Regulates the Uracil Transporter Fur4.
Topics: Carbon-Nitrogen Ligases; Cell Membrane; Chromatography, High Pressure Liquid; Down-Regulation; Fluorouracil; Gene Deletion; Golgi Apparatus; Mass Spectrometry; Microscopy, Fluorescence; Mutation; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Ubiquitination; Uracil; Vacuoles | 2015 |
Oral tegafur-uracil as metronomic therapy following intravenous FOLFOX for stage III colon cancer.
Topics: Administration, Intravenous; Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colonic Neoplasms; Disease-Free Survival; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Neoplasm Staging; Organoplatinum Compounds; Retrospective Studies; Survival Rate; Tegafur; Uracil | 2017 |
Pretreatment serum uracil concentration as a predictor of severe and fatal fluoropyrimidine-associated toxicity.
Topics: Adult; Aged; Aged, 80 and over; Alleles; Antimetabolites, Antineoplastic; Biomarkers; Capecitabine; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); Drug-Related Side Effects and Adverse Reactions; Female; Fluorouracil; Genotype; Hospitalization; Humans; Leukocytes, Mononuclear; Male; Middle Aged; Neoplasms; Pharmacogenomic Testing; Pharmacogenomic Variants; Phenotype; Predictive Value of Tests; Prospective Studies; Thymidylate Synthase; Uracil; Young Adult | 2017 |
Adoptive immunotherapy combined with FP treatment for head and neck cancer: An in vitro study.
Topics: Antigens, Neoplasm; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Proliferation; Cisplatin; Combined Modality Therapy; Cytomegalovirus; Drug Resistance, Neoplasm; Fluorouracil; Head and Neck Neoplasms; Humans; Immunotherapy, Adoptive; Interferon-gamma; Myeloid-Derived Suppressor Cells; Neoplasm Staging; Phosphoproteins; T-Lymphocytes, Cytotoxic; T-Lymphocytes, Regulatory; Tegafur; Tumor Microenvironment; Uracil; Viral Matrix Proteins | 2017 |
The Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio Are Prognostic Factors in Patients with Locally Advanced Pancreatic Cancer Treated with Chemoradiotherapy.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Blood Platelets; Capecitabine; Chemoradiotherapy; Cisplatin; Deoxycytidine; Disease Progression; Disease-Free Survival; Drug Administration Schedule; Female; Fluorouracil; Gemcitabine; Humans; Lymphocyte Count; Lymphocytes; Male; Middle Aged; Neutrophils; Pancreatic Neoplasms; Platelet Count; Prognosis; Retrospective Studies; Tegafur; Tumor Burden; Uracil | 2018 |
Identification of Predictors of Recurrence in Patients with Lower Rectal Cancer Undergoing Neoadjuvant Chemotherapy: A Direct Comparison of Short-Course and Long-Course Chemoradiotherapy.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Recurrence, Local; Neoplasm Staging; Rectal Neoplasms; Retrospective Studies; Survival Rate; Tegafur; Uracil | 2019 |
Cost minimization comparison of oral UFT/leucovorin versus 5-fluorouracil/leucovorin as adjuvant therapy for colorectal cancer in Taiwan.
Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colorectal Neoplasms; Combined Modality Therapy; Cost Control; Female; Fluorouracil; Health Care Costs; Humans; Leucovorin; Male; Middle Aged; Taiwan; Tegafur; Treatment Outcome; Uracil; Vitamin B Complex | 2019 |
[5-FU: At last!]
Topics: Acetates; Antidotes; Antimetabolites, Antineoplastic; Dihydropyrimidine Dehydrogenase Deficiency; Fluorouracil; Humans; Neoplasms; Practice Guidelines as Topic; Pyrimidines; Uracil; Uridine | 2019 |
ABHD5 blunts the sensitivity of colorectal cancer to fluorouracil via promoting autophagic uracil yield.
Topics: 1-Acylglycerol-3-Phosphate O-Acyltransferase; Animals; Antimetabolites, Antineoplastic; Autophagy; Biomarkers, Tumor; Carcinogenesis; Chemotherapy, Adjuvant; Colorectal Neoplasms; Datasets as Topic; Disease Progression; Disease-Free Survival; Drug Resistance, Neoplasm; Fluorouracil; Gene Knockdown Techniques; HCT116 Cells; Humans; Kaplan-Meier Estimate; Lysosomes; Male; Mice; Mice, Inbred BALB C; Mice, Inbred NOD; Mice, Nude; Mice, SCID; Ribonucleases; Tumor Suppressor Proteins; Uracil; Xenograft Model Antitumor Assays | 2019 |
A 12-year Recurrence-free Survival After Multidisciplinary Treatment for a Patient With Combined Hepatocellular-Cholangiocarcinoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bile Duct Neoplasms; Carcinoma, Hepatocellular; Cholangiocarcinoma; Cisplatin; Disease-Free Survival; Female; Fluorouracil; Gamma Rays; Hepatectomy; Humans; Liver Neoplasms; Middle Aged; Mitomycin; Tegafur; Uracil | 2019 |
Fluoropyrimidines and DPD testing: is there truly an inexorable link?
Topics: Antineoplastic Agents; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Fluorouracil; Genotype; Humans; Neoplasms; Oxonic Acid; Pharmacogenomic Testing; Phenotype; Point-of-Care Testing; Pyrrolidines; Tegafur; Thymine; Trifluridine; Uracil | 2019 |
Lymph-node ratio is an important clinical determinant for selecting the appropriate adjuvant chemotherapy regimen for curative D2-resected gastric cancer.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Chemotherapy, Adjuvant; Choice Behavior; Cisplatin; Combined Modality Therapy; Deoxycytidine; Female; Fluorouracil; Gastrectomy; Humans; Lymph Node Excision; Lymph Nodes; Male; Middle Aged; Neoplasm Staging; Oxaloacetates; Predictive Value of Tests; Prognosis; Retrospective Studies; Stomach Neoplasms; Survival Analysis; Tegafur; Uracil | 2019 |
Suppressive impact of metronomic chemotherapy using UFT and/or cyclophosphamide on mediators of breast cancer dissemination and invasion.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Line, Tumor; Cyclophosphamide; Female; Fluorouracil; Humans; Mice; Mice, SCID; Neoplasm Invasiveness; Neovascularization, Pathologic; Tegafur; Uracil; Xenograft Model Antitumor Assays | 2019 |
Review of metastatic colorectal cancer treatment pathways and early clinical experience of trifluridine/tipiracil in the UK named patient programme.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Disease Progression; Drug Combinations; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Neoplasm Metastasis; Organoplatinum Compounds; Pyrrolidines; Thymine; Treatment Outcome; Trifluridine; United Kingdom; Uracil | 2020 |
A Simple and Rapid UPLC-UV Method for Detecting DPD Deficiency in Patients With Cancer.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Biomarkers; Capecitabine; Chromatography, High Pressure Liquid; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasms; Spectrophotometry, Ultraviolet; Uracil | 2020 |
5-Nitrouracil stabilizes the plasma concentration values of 5-FU in colorectal cancer patients receiving capecitabine.
Topics: Adult; Antimetabolites, Antineoplastic; Biotransformation; Capecitabine; Colorectal Neoplasms; Female; Fluorouracil; Humans; Liver; Male; Temperature; Thymidine Phosphorylase; Time Factors; Uracil | 2020 |
New uracil analog U-332 is an inhibitor of NF-κB in 5-fluorouracil-resistant human leukemia HL-60 cell line.
Topics: Antimetabolites, Antineoplastic; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluorouracil; Genes, rel; HL-60 Cells; Humans; Leukemia; NF-kappa B; Transcription Factor RelA; Uracil | 2020 |
Population Pharmacokinetic Model-Based Evaluation of Circadian Variations in Plasma 5-Fluorouracil Concentrations During Long-Term Infusion in Rats: A Comparison With Oral Anticancer Prodrugs.
Topics: Administration, Oral; Animals; Fluorouracil; Prodrugs; Rats; Tegafur; Uracil | 2020 |
Phenotyping of Uracil and 5-Fluorouracil Metabolism Using LC-MS/MS for Prevention of Toxicity and Dose Adjustment of Fluoropyrimidines.
Topics: Antimetabolites, Antineoplastic; Chromatography, Liquid; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Humans; Retrospective Studies; Tandem Mass Spectrometry; Uracil | 2020 |
New DPYD variants causing DPD deficiency in patients treated with fluoropyrimidine.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Capecitabine; Computer Simulation; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouracil; Humans; Male; Middle Aged; Pharmacogenomic Variants; Polymorphism, Single Nucleotide; Retrospective Studies; Uracil | 2020 |
Antimicrobial Peptide Induced-Stress Renders
Topics: Anti-Bacterial Agents; Antimetabolites; Antimicrobial Cationic Peptides; Bacterial Proteins; Deoxycytidine; Drug Therapy, Combination; Fluorouracil; Gemcitabine; Gene Expression Regulation, Bacterial; Microbial Sensitivity Tests; Microbial Viability; Nucleosides; Proteome; Staphylococcus aureus; Stress, Physiological; Thioguanine; Uracil | 2020 |
Simultaneous quantification method for 5-FU, uracil, and tegafur using UPLC-MS/MS and clinical application in monitoring UFT/LV combination therapy after hepatectomy.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Calibration; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Drug Monitoring; Fluorouracil; Hepatectomy; Humans; Leucovorin; Liver; Liver Neoplasms; Sensitivity and Specificity; Tandem Mass Spectrometry; Tegafur; Uracil | 2021 |
Structural basis for the interaction modes of dihydroorotase with the anticancer drugs 5-fluorouracil and 5-aminouracil.
Topics: Antineoplastic Agents; Binding Sites; Crystallization; Crystallography, X-Ray; Dihydroorotase; Escherichia coli; Fluorouracil; Malates; Models, Molecular; Protein Binding; Saccharomyces cerevisiae; Uracil | 2021 |
Pre-analytical considerations for the analysis of uracil and 5,6-dihydrouracil in heparin plasma.
Topics: Fluorouracil; Heparin; Humans; Plasma; Uracil | 2022 |
Determination of 5-Formyluracil via Oxime-Based Nucleotide-Metal Coordination.
Topics: Acetamides; DNA; Fluorouracil; Nucleotides; Oximes; Uracil | 2022 |
Renal impairment and DPD testing: Watch out for false-positive results!
Topics: Antimetabolites, Antineoplastic; Capecitabine; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Humans; Neoplasms; Renal Insufficiency; Uracil | 2022 |
Uncovering the roles of dihydropyrimidine dehydrogenase in fatty-acid induced steatosis using human cellular models.
Topics: Dihydrouracil Dehydrogenase (NADP); Fatty Acids; Fluorouracil; Humans; Uracil | 2022 |
Quantification of uracil, dihydrouracil, thymine and dihydrothymine for reliable dihydropyrimidine dehydrogenase (DPD) phenotyping critically depend on blood and plasma storage conditions.
Topics: Biomarkers; Capecitabine; Chromatography, Liquid; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Humans; Tandem Mass Spectrometry; Thymine; Uracil | 2022 |
Quantitative impact of pre-analytical process on plasma uracil when testing for dihydropyrimidine dehydrogenase deficiency.
Topics: Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Humans; Phenotype; Plasma; Uracil | 2023 |
Dihydropyrimidine dehydrogenase (DPD) genotype and phenotype among Danish cancer patients: prevalence and correlation between
Topics: Denmark; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Genotype; Humans; Neoplasms; Phenotype; Prevalence; Uracil | 2022 |
Response to "Plasma Uracil as a DPD Phenotyping Test: Pre-analytical Handling Matters".
Topics: Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Humans; Uracil | 2023 |
Plasma Uracil as a DPD Phenotyping Test: Pre-Analytical Handling Matters!
Topics: Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Humans; Uracil | 2023 |
Synthesis and Biological Evaluation of Novel Uracil Derivatives as Thymidylate Synthase Inhibitors.
Topics: Breast Neoplasms; Enzyme Inhibitors; Female; Fluorouracil; Humans; Thymidylate Synthase; Uracil | 2023 |
A Pharmacokinetic-Pharmacodynamic Model Predicts Uracil-tegafur Effect on Tumor Shrinkage and Myelosuppression in a Colorectal Cancer Rat Model.
Topics: Administration, Oral; Animals; Colorectal Neoplasms; Fluorouracil; Rats; Tegafur; Uracil | 2023 |
Short-term biological variation of plasma uracil in a Caucasian healthy population.
Topics: Biomarkers; Chromatography, Liquid; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Humans; Tandem Mass Spectrometry; Uracil | 2023 |
Impact of renal impairment on dihydropyrimidine dehydrogenase (DPD) phenotyping.
Topics: Antimetabolites, Antineoplastic; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Humans; Uracil | 2023 |
Effects of six pyrimidine analogs on the growth of Tetrahymena thermophila and their implications in pyrimidine metabolism.
Topics: Antimetabolites; Cytarabine; Floxuridine; Fluorouracil; Gemcitabine; Nucleosides; Pyrimidines; Tetrahymena thermophila; Thymine; Uracil | 2023 |