uracil and ar c155858
uracil has been researched along with ar c155858 in 18 studies
Research
Studies (18)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 16 (88.89) | 24.3611 |
| 2020's | 2 (11.11) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Davies, AJ; Halestrap, AP; Murray, CM; Ovens, MJ; Wilson, MC | 1 |
| Halestrap, AP; Manoharan, C; Murray, CM; Ovens, MJ; Wilson, MC | 1 |
| Chiche, J; Critchlow, SE; Ilc, K; Ilk, K; Le Floch, R; Marchiq, I; Murray, CM; Naiken, T; Pouysségur, J; Roux, D; Simon, MP | 1 |
| Bouzin, C; Draoui, N; Feron, O; Riant, O; Schicke, O; Seront, E; Sonveaux, P | 1 |
| Harrison, H; Hulit, J; Lamb, R; Lisanti, MP; Smith, DL; Sotgia, F | 1 |
| Halestrap, AP; Nancolas, B; Sessions, RB | 1 |
| Morris, ME; Morse, BL; Vijay, N | 1 |
| Abe, M; Amachi, R; Hanson, DJ; Harada, T; Hiasa, M; Horikawa, K; Itoh, K; Matsumoto, T; Miki, H; Nakamura, S; Oda, A; Teramachi, J; Tsuji, D | 1 |
| Guo, Y; Jiang, L | 1 |
| Ahn, SM; Chang, WJ; Cho, JH; Jung, KS; Kang, WK; Kim, HS; Kim, KM; Kim, ST; Kim, SY; Lee, I; Lee, J; Lee, JY; Lee, S; Lim, HY; Lim, SH; Park, JO; Park, SH; Park, YS; Song, HN; Yoo, KH | 1 |
| Becker, HM; Deitmer, JW; Forero-Quintero, LS | 1 |
| MacGregor, GG; Pivovarova, AI | 1 |
| Bastien, E; Becker, HM; Chaltin, P; Corbet, C; Doix, B; Draoui, N; Feron, O; Jordan, BF; Marchand, A; Mignion, L; Riant, O; Schakman, O; Vanherck, JC | 1 |
| Guan, X; Morris, ME; Ruszaj, D | 1 |
| Eichner, R; Girardi, E; Hashimoto, M; Superti-Furga, G | 1 |
| Guan, X; Morris, ME; Rodriguez-Cruz, V | 1 |
| Juvale, K; Puri, S | 1 |
| Eliopoulos, E; Papakonstantinou, E; Thireou, T; Vlachakis, D; Vlachoyiannopoulos, PG | 1 |
Reviews
1 review(s) available for uracil and ar c155858
| Article | Year |
|---|---|
Monocarboxylate transporter 1 and 4 inhibitors as potential therapeutics for treating solid tumours: A review with structure-activity relationship insights.
Topics: Antineoplastic Agents; Drug Resistance, Neoplasm; Humans; Monocarboxylic Acid Transporters; Muscle Proteins; Neoplasms; Pyrimidinones; Structure-Activity Relationship; Symporters; Thiophenes; Uracil | 2020 |
Other Studies
17 other study(ies) available for uracil and ar c155858
| Article | Year |
|---|---|
AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10.
Topics: Animals; Binding Sites; Catalytic Domain; Chickens; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Erythrocytes; Monocarboxylic Acid Transporters; Phenylalanine; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Rats; Symporters; Thiophenes; Uracil; Xenopus laevis | 2010 |
The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated by the associated ancillary protein.
Topics: Animals; Basigin; Erythrocytes; Glycoproteins; Kinetics; Lactic Acid; Membrane Proteins; Monocarboxylic Acid Transporters; Mutant Proteins; Oocytes; Rabbits; Rats; Recombinant Proteins; Symporters; Thiophenes; Uracil; Xenopus laevis; Xenopus Proteins | 2010 |
CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors.
Topics: Basigin; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; DNA Primers; Flow Cytometry; Fluorescent Antibody Technique; Gene Knockout Techniques; Gene Silencing; Glycolysis; Humans; Immunohistochemistry; Lactic Acid; Monocarboxylic Acid Transporters; Muscle Proteins; Oxygen Consumption; Protein Subunits; Symporters; Thiophenes; Uracil | 2011 |
Antitumor activity of 7-aminocarboxycoumarin derivatives, a new class of potent inhibitors of lactate influx but not efflux.
Topics: Animals; Breast Neoplasms; Colorectal Neoplasms; Coumarins; Female; HCT116 Cells; Humans; Lactic Acid; MCF-7 Cells; Mice; Neoplasm Recurrence, Local; Prognosis; Thiophenes; Uracil | 2014 |
Mitochondria as new therapeutic targets for eradicating cancer stem cells: Quantitative proteomics and functional validation via MCT1/2 inhibition.
Topics: Breast Neoplasms; Cell Line, Tumor; Female; Humans; MCF-7 Cells; Mitochondria; Mitochondrial Proteins; Molecular Targeted Therapy; Monocarboxylic Acid Transporters; Neoplastic Stem Cells; Proteomics; Symporters; Thiophenes; Uracil | 2014 |
Identification of key binding site residues of MCT1 for AR-C155858 reveals the molecular basis of its isoform selectivity.
Topics: Amino Acid Substitution; Amino Acids; Animals; Binding Sites; Biological Transport; Female; Gene Expression; Humans; Lactic Acid; Mice; Molecular Docking Simulation; Monocarboxylic Acid Transporters; Muscle Proteins; Mutagenesis, Site-Directed; Oocytes; Protein Binding; Rats; Recombinant Proteins; Symporters; Thiophenes; Uracil; Xenopus laevis | 2015 |
A Novel Monocarboxylate Transporter Inhibitor as a Potential Treatment Strategy for γ-Hydroxybutyric Acid Overdose.
Topics: Administration, Intravenous; Administration, Oral; Animals; Antidotes; Brain; Cell Line; Drug Overdose; Kidney; Male; Metabolic Clearance Rate; Monocarboxylic Acid Transporters; Rats, Sprague-Dawley; Renal Reabsorption; Respiratory Insufficiency; Respiratory Rate; Sodium Oxybate; Thiophenes; Tissue Distribution; Uracil | 2015 |
Effective impairment of myeloma cells and their progenitors by blockade of monocarboxylate transportation.
Topics: Cell Death; Cell Line, Tumor; Coumaric Acids; Gene Knockdown Techniques; Humans; Hydrogen-Ion Concentration; Metformin; Molecular Targeted Therapy; Monocarboxylic Acid Transporters; Multiple Myeloma; Muscle Proteins; Neoplastic Stem Cells; Symporters; Thiophenes; Uracil | 2015 |
Organic anion transporting polypeptide 2 transports valproic acid in rat brain microvascular endothelial cells.
Topics: Acetonitriles; Animals; Animals, Newborn; Anticonvulsants; Brain; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Inhibitors; Gene Expression Regulation; Microvessels; Organic Anion Transporters; Pregnenolone; Rats; Rats, Wistar; RNA, Messenger; RNA, Small Interfering; Thiophenes; Time Factors; Uracil; Valproic Acid | 2016 |
MCT4 as a potential therapeutic target for metastatic gastric cancer with peritoneal carcinomatosis.
Topics: Adult; Aged; Aged, 80 and over; Animals; Antineoplastic Agents; Cell Proliferation; Cell Survival; Female; Humans; Lactic Acid; Male; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Monocarboxylic Acid Transporters; Muscle Proteins; Peritoneal Neoplasms; RNA Interference; RNA, Small Interfering; Stomach Neoplasms; Symporters; Thiophenes; Up-Regulation; Uracil; Xenograft Model Antitumor Assays | 2016 |
Reduction of epileptiform activity in ketogenic mice: The role of monocarboxylate transporters.
Topics: 3-Hydroxybutyric Acid; Animals; Astrocytes; Brain; Diet, Ketogenic; Disease Models, Animal; Epilepsy; Gene Expression Regulation; Glycolysis; Ketone Bodies; Lactic Acid; Mice; Mice, Inbred C57BL; Microtomy; Monocarboxylic Acid Transporters; Neurons; Primary Cell Culture; Seizures; Signal Transduction; Symporters; Thiophenes; Tissue Culture Techniques; Uracil | 2017 |
Glucose-dependent growth arrest of leukemia cells by MCT1 inhibition: Feeding Warburg's sweet tooth and blocking acid export as an anticancer strategy.
Topics: Antineoplastic Agents; Cell Cycle Checkpoints; Glucose; Growth Inhibitors; Humans; K562 Cells; Leukemia; MCF-7 Cells; Monocarboxylic Acid Transporters; Symporters; Thiophenes; Uracil | 2018 |
Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects.
Topics: Animals; Antineoplastic Agents; Biological Transport; Cell Line, Tumor; Female; Gene Silencing; Glucose; Glycolysis; Humans; Ion Transport; Lactic Acid; Male; MCF-7 Cells; Mice; Mice, Inbred C57BL; Mitochondria; Monocarboxylic Acid Transporters; Muscle Proteins; Neoplasm Transplantation; Oxygen; Pyruvic Acid; Radiation-Sensitizing Agents; Rats; RNA, Small Interfering; Symporters; Thiophenes; Uracil; Xenopus laevis | 2018 |
Development and validation of a liquid chromatography tandem mass spectrometry assay for AZD3965 in mouse plasma and tumor tissue: Application to pharmacokinetic and breast tumor xenograft studies.
Topics: Acetonitriles; Animals; Atmospheric Pressure; Breast Neoplasms; Cell Line, Tumor; Chromatography, Liquid; Female; Heterografts; Mice; Plasma; Pyrimidines; Pyrimidinones; Reproducibility of Results; Tandem Mass Spectrometry; Thiophenes; Uracil | 2018 |
Detection of Chemical Engagement of Solute Carrier Proteins by a Cellular Thermal Shift Assay.
Topics: Biological Assay; Excitatory Amino Acid Transporter 2; Formates; Glutamate Plasma Membrane Transport Proteins; Heating; HEK293 Cells; Humans; Lactic Acid; Ligands; Monocarboxylic Acid Transporters; Protein Binding; Protein Stability; Pyrimidinones; Thiophenes; Uracil | 2018 |
Cellular Uptake of MCT1 Inhibitors AR-C155858 and AZD3965 and Their Effects on MCT-Mediated Transport of L-Lactate in Murine 4T1 Breast Tumor Cancer Cells.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Coumaric Acids; Drug Screening Assays, Antitumor; Female; Humans; Hydrogen-Ion Concentration; Lactic Acid; Mice; Monocarboxylic Acid Transporters; Pyrimidinones; Symporters; Thiophenes; Uracil | 2019 |
A Holistic Evolutionary and 3D Pharmacophore Modelling Study Provides Insights into the Metabolism, Function, and Substrate Selectivity of the Human Monocarboxylate Transporter 4 (hMCT4).
Topics: Animals; Antineoplastic Agents; Binding Sites; Biological Transport; Drug Design; Glycolysis; Humans; Lactic Acid; Molecular Docking Simulation; Monocarboxylic Acid Transporters; Muscle Proteins; Phloretin; Phylogeny; Protein Binding; Protein Conformation, alpha-Helical; Protein Interaction Domains and Motifs; Protein Isoforms; Pyrimidinones; Quercetin; Reserpine; Structural Homology, Protein; Substrate Specificity; Thiophenes; Uracil | 2021 |