unithiol and succimer
unithiol has been researched along with succimer in 97 studies
Research
Studies (97)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (19.59) | 18.7374 |
| 1990's | 31 (31.96) | 18.2507 |
| 2000's | 31 (31.96) | 29.6817 |
| 2010's | 15 (15.46) | 24.3611 |
| 2020's | 1 (1.03) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Lubianova, IP | 1 |
| Funakoshi, T; Kiyozumi, M; Kojima, S; Shimada, H; Takahashi, Y | 1 |
| Benov, LC; Monovich, OH; Ribarov, SR | 1 |
| Chisolm, JJ | 1 |
| Aposhian, HV; Bruce, DC; Carter, D; Dart, RC; Fernando, Q; Hurlbut, KM; Levine, DJ; Maiorino, RM; Rivera, M; Zheng, W | 1 |
| Kiyozumi, M; Kojima, S; Tagawa, Y; Takahashi, Y | 1 |
| Fichtl, B; Forth, W; Kreppel, H; Reichl, FX; Schäfer, B | 1 |
| Aposhian, HV; Brendel, K; Maiorino, RM; Zheng, W | 1 |
| Bright, JE; Inns, RH; Marrs, TC; Rice, P | 1 |
| Fichtl, B; Forth, W; Kreppel, H; Reichl, FX; Szinicz, L | 1 |
| Dill, K; Hallowell, SF; McGown, EL; O'Connor, RJ | 1 |
| Cao, BJ; Chen, ZK; Chi, ZQ | 1 |
| Buchet, JP; Lauwerys, RR | 1 |
| Aposhian, HV; Maiorino, RM | 2 |
| Fichtl, B; Forth, W; Kreppel, H; Reichl, FX | 1 |
| Flemming, C; Gray, BH; Lee, LH; Porvaznik, M | 1 |
| Aposhian, HV; Aposhian, MM; Dart, RC; Dawson, BV | 1 |
| Basinger, MA; Forti, RL; Gibbs, SJ; Jones, MM; Mitchell, WM | 1 |
| Aposhian, HV; Barry, TJ; Maiorino, RM | 1 |
| Dumlao, CR; Knudsen, JJ; McGown, EL; Tillotson, JA | 1 |
| Aposhian, HV; Tadlock, CH | 1 |
| Planas-Bohne, F | 2 |
| Aposhian, HV; Moon, TE; Tadlock, CH | 1 |
| Aposhian, HV | 2 |
| Aposhian, HV; Brinkley, FB; Hackley, BE; Hsu, CA; Mershon, MM | 1 |
| Aposhian, HV; Carter, DE; Hoover, TD; Hsu, CA; Maiorino, RM; Stine, E | 1 |
| Maehashi, H; Tsutsumi, S; Yamaguchi, Y | 1 |
| Fichtl, B; Forth, W; Kreppel, H; Mückter, H; Reichl, FX; Szinicz, L | 1 |
| Doklea, E; Fichtl, B; Forth, W; Liebl, B; Mückter, H | 1 |
| Aposhian, HV; Aposhian, MM; Dart, RC; Gonzalez-Ramirez, D; Hurlbut, KM; Junco-Munoz, P; Maiorino, RM; Xu, Z; Zuniga-Charles, M | 1 |
| Arora, U; Dube, SN; Flora, SJ; Kannan, GM; Malhotra, PR; Shukla, MK | 1 |
| Aaseth, J; Andersen, O; Jacobsen, D; Wickstrøm, E | 1 |
| Flora, SJ; Mathur, R; Mathur, S | 1 |
| Inns, RH; Rice, P | 1 |
| Klimmek, R; Krettek, C; Werner, HW | 1 |
| Zalups, RK | 1 |
| Aihie, A; Brooks, D; Fysh, R; Jones, S; Kew, J; Morris, C | 1 |
| Doklea, E; Fichtl, B; Forth, W; Hopfer, C; Islambouli, S; Mückter, H; Szinicz, L | 1 |
| Gale, GR; Jones, MM; Singh, PK; Smith, AB | 1 |
| Ahmad, N; Farookh, A; Gupta, S; Hasan, SK; Husain, MM; Srivastava, RC | 1 |
| Mückter, H; Pfab, R; Roider, G; Zilker, T | 1 |
| Ewan, KB; Pamphlett, R | 1 |
| Gansow, OA; Garmestani, K; Jones, SB; Kozak, RW; Tiffany, LJ | 1 |
| Aposhian, HV; Fernando, Q; Gandolfi, AJ; Keith, RL; Setiarahardjo, I | 1 |
| Fichtl, B; Hunder, G; Liebl, B; Mückter, H; Reichl, FX; Walther, U | 1 |
| Flora, SJ; Tripathi, N | 1 |
| De Wolff, FA; Noach, LA; Slikkerveer, A; Tytgat, GN; Van der Voet, GB | 1 |
| Hennighausen, G; Kröning, G; Merkord, J; Weber, H | 1 |
| Nogueira, CW; Rocha, JB; Rotta, LL; Souza, DO; Tavares, RG | 1 |
| Flohé, S; Kehe, K; Krebs, G; Kreppel, H; Liebl, B; Reichl, FX; Szinicz, L | 1 |
| Binns, H; Shannon, M; Woolf, A | 1 |
| Nogueira, CW; Rocha, JB; Souza, DO | 1 |
| Burckhardt, BC; Burckhardt, G; Drinkuth, B; König, A; Menzel, C; Steffgen, J; Wright, SH | 1 |
| Patrick, L | 1 |
| Muller, D; Nascimento, PC; Nogueira, CW; Rocha, JB; Soares, FA | 1 |
| Henkel, R; Schill, WB; Wroblewski, N | 1 |
| Aposhian, HV; Aposhian, MM; Maiorino, RM; Morgan, DL; Queen, HL | 1 |
| Nogueira, CW; Rocha, JB; Santos, FW; Soares, FA | 1 |
| Buttigieg, GA; Denton, MB; Gailer, J; George, GN; Harris, HH; Pickering, IJ; Prince, RC | 1 |
| Flora, SJ; Saxena, G | 1 |
| Blanusa, M; Juresa, D; Kostial, K | 1 |
| Gonçales, CE; Nogueira, CW; Rocha, JB; Santos, FW | 1 |
| Cabassa, C; Flombaum, CD; Jaggi, JS; Kappel, BJ; McDevitt, MR; Scheinberg, DA; Sgouros, G | 1 |
| Bhadauria, S; Dhaked, RK; Flora, SJ; Pant, SC | 1 |
| Nogueira, CW; Rocha, JB; Santos, FW | 1 |
| Aposhian, HV; Aposhian, MM | 1 |
| Gurr, JR; Jan, KY; Ramanathan, B; Wang, TC | 1 |
| Drasch, G; Eyer, F; Felgenhauer, N; Pfab, R; Zilker, T | 1 |
| Luchese, C; Nogueira, CW; Rocha, JB; Santos, FW; Zeni, G | 1 |
| Flora, G; Flora, SJ; Mishra, M; Saxena, G | 1 |
| Bridges, CC; Joshee, L; Zalups, RK | 3 |
| Hjelmhaug, J; Lobner, D; Rush, T | 1 |
| Bridges, CC; Zalups, RK | 2 |
| Gregus, Z; Németi, B | 1 |
| Geerlings, P; Gregus, Z; Németi, B; Roos, G | 1 |
| Ariño, C; Chekmeneva, E; Díaz-Cruz, JM; Esteban, M | 1 |
| Guzzi, G; Marsili, C; Pigatto, PD | 1 |
| Guzzi, G; Minoia, C; Pigatto, P; Ronchi, A | 1 |
| Charlier, C; Denooz, R; Ho, G; Keutgens, A; Kotolenko, S; Schoofs, R | 1 |
| Requejo, R; Tena, M | 1 |
| Gailer, J; Zeini Jahromi, E | 1 |
| Ariño, C; Cavanillas, S; Chekmeneva, E; Díaz-Cruz, JM; Esteban, M | 1 |
| Kosnett, MJ | 1 |
| Gailer, J; George, GN; Pickering, IJ; Zeini Jahromi, E | 1 |
| Aaseth, J; Andersen, O; Cao, Y; Skaug, MA | 2 |
| Gao, J; Huang, D; Zhou, H | 1 |
| Katakura, A; Kawaguchi, M; Okubo, M; Sato, K; Tsukagoshi, E; Yajima, Y; Yoshikawa, M | 1 |
| Aaseth, J; Bjørklund, G; Mutter, J | 1 |
| Gresham, C; Hsiao, CY; Marshall, MR | 1 |
| Aaseth, J; Alexander, J; Bjørklund, G; Crisponi, G; Djordjevic, AB; Nurchi, VM | 1 |
Reviews
14 review(s) available for unithiol and succimer
| Article | Year |
|---|---|
DMSA and DMPS--water soluble antidotes for heavy metal poisoning.
Topics: Animals; Antidotes; Arsenic Poisoning; Biotransformation; Cadmium Poisoning; Dimercaprol; Forecasting; Humans; Kinetics; Lead Poisoning; Mercury Poisoning; Metals; Solubility; Succimer; Sulfhydryl Compounds; Unithiol | 1983 |
Mobilization of heavy metals by newer, therapeutically useful chelating agents.
Topics: Animals; Chelating Agents; Dimercaprol; Edetic Acid; Humans; Metals; Succimer; Unithiol | 1995 |
Treatment of mercury and lead poisonings with dimercaptosuccinic acid and sodium dimercaptopropanesulfonate. A review.
Topics: Dental Amalgam; Humans; Lead Poisoning; Mercury Poisoning; Succimer; Unithiol; Volatilization | 1995 |
Are we ready to replace dimercaprol (BAL) as an arsenic antidote?
Topics: Animals; Antidotes; Arsenic Poisoning; Dimercaprol; Dogs; Guinea Pigs; Humans; Mice; Poisoning; Rats; Succimer; Unithiol | 1997 |
Mercury toxicity and antioxidants: Part 1: role of glutathione and alpha-lipoic acid in the treatment of mercury toxicity.
Topics: Animals; Antioxidants; Blood-Brain Barrier; Chelating Agents; Food Contamination; Glutathione; Humans; Kidney; Mercury; Mercury Poisoning; Succimer; Thioctic Acid; Tissue Distribution; Unithiol | 2002 |
Arsenic toxicology: five questions.
Topics: Animals; Arsenic; Arsenic Poisoning; Arsenites; Aryl Hydrocarbon Hydroxylases; Chelating Agents; Cytochrome P-450 CYP2C19; Dimercaprol; Enzyme Inhibitors; Glutathione Transferase; Hemoglobins; Humans; Metallothionein; Methylation; Mixed Function Oxygenases; Polymorphism, Genetic; Protein Binding; Pyruvate Dehydrogenase Complex; Reactive Oxygen Species; Succimer; Unithiol | 2006 |
Arsenic and lead induced free radical generation and their reversibility following chelation.
Topics: Acetylcysteine; Adjuvants, Pharmaceutic; Animals; Antioxidants; Arsenic; Arsenic Poisoning; Ascorbic Acid; Calcium; Chelating Agents; Free Radicals; Humans; Lead; Lead Poisoning; Melatonin; Metals; Micronutrients; Molecular Structure; Succimer; Taurine; Thioctic Acid; Unithiol; Vitamin E | 2007 |
Relationships between the renal handling of DMPS and DMSA and the renal handling of mercury.
Topics: Animals; Chelating Agents; Dicarboxylic Acid Transporters; gamma-Glutamyltransferase; Humans; Kidney; Mercury; Mercury Poisoning; Organic Anion Transporters; Succimer; Sulfhydryl Compounds; Unithiol | 2012 |
The role of chelation in the treatment of arsenic and mercury poisoning.
Topics: Animals; Arsenic Poisoning; Arsenicals; Chelating Agents; Chelation Therapy; Humans; Mercury Poisoning; Succimer; Treatment Outcome; Unithiol | 2013 |
Chelation therapy in intoxications with mercury, lead and copper.
Topics: Administration, Oral; Animals; Chelating Agents; Chelation Therapy; Copper; Drug Therapy, Combination; Evidence-Based Medicine; Free Radical Scavengers; Humans; Infusions, Parenteral; Lead Poisoning; Mercury Poisoning; Penicillamine; Succimer; Trientine; Unithiol | 2015 |
Chelation in metal intoxication--Principles and paradigms.
Topics: Administration, Oral; Antidotes; Benzoates; Chelating Agents; Deferasirox; Deferiprone; Deferoxamine; Heavy Metal Poisoning; Humans; Penicillamine; Poisoning; Pyridones; Succimer; Triazoles; Trientine; Unithiol | 2015 |
Metal chelators and neurotoxicity: lead, mercury, and arsenic.
Topics: Arsenic Poisoning; Chelating Agents; Edetic Acid; Humans; Lead Poisoning, Nervous System; Mercury Poisoning, Nervous System; Monensin; Succimer; Unithiol | 2017 |
Treatment of lead and arsenic poisoning in anuric patients - a case report and narrative review of the literature.
Topics: Adult; Animals; Anuria; Arsenic Poisoning; Chelating Agents; Continuous Renal Replacement Therapy; Dimercaprol; Edetic Acid; Humans; Kidney Failure, Chronic; Lead Poisoning; Male; Renal Dialysis; Succimer; Unithiol | 2019 |
Arsenic Toxicity: Molecular Targets and Therapeutic Agents.
Topics: Animals; Antidotes; Arsenic; Arsenic Poisoning; Arsenicals; Chelating Agents; Dimercaprol; Drinking Water; Humans; Models, Molecular; Occupational Exposure; Oxidative Stress; Succimer; Unithiol; Water Pollutants, Chemical | 2020 |
Trials
1 trial(s) available for unithiol and succimer
| Article | Year |
|---|---|
Comparison of enhanced elimination of bismuth in humans after treatment with meso-2,3-dimercaptosuccinic acid and D,L-2,3-dimercaptopropane-1-sulfonic acid.
Topics: Adult; Aged; Analysis of Variance; Antacids; Bismuth; Chelating Agents; Gastritis; Helicobacter Infections; Humans; Middle Aged; Organometallic Compounds; Single-Blind Method; Succimer; Unithiol | 1998 |
Other Studies
82 other study(ies) available for unithiol and succimer
| Article | Year |
|---|---|
[Pharmacodynamic characteristics of dithiol compounds and D-penicillamine in microsaturnism].
Topics: Adult; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Lead Poisoning; Male; Middle Aged; Occupational Diseases; Penicillamine; Succimer; Sulfhydryl Compounds; Unithiol | 1979 |
Characterization of gold in urine and bile following administration of gold sodium thiomalate with chelating agents to rats.
Topics: Animals; Bile; Chelating Agents; Chromatography; Cysteine; Electrophoresis; Gold; Gold Sodium Thiomalate; Injections, Intravenous; Male; Penicillamine; Rats; Rats, Inbred Strains; Succimer; Unithiol | 1992 |
Study of activated oxygen production by some thiols using chemiluminescence.
Topics: Cysteine; Glutathione; Kinetics; Lipid Peroxidation; Luminescent Measurements; Malondialdehyde; Oxidation-Reduction; Penicillamine; Succimer; Sulfhydryl Compounds; Superoxides; Unithiol | 1992 |
BAL, EDTA, DMSA and DMPS in the treatment of lead poisoning in children.
Topics: Administration, Oral; Beverages; Chelation Therapy; Child; Child, Preschool; Dimercaprol; Edetic Acid; Female; Housing; Humans; Infant; Lead; Lead Poisoning; Male; Penicillamine; Succimer; Unithiol | 1992 |
Human studies with the chelating agents, DMPS and DMSA.
Topics: Adult; Aniline Compounds; Animals; Dental Amalgam; Dimercaprol; Humans; Male; Mercury; Mercury Poisoning; Molecular Structure; Protein Binding; Rats; Succimer; Unithiol | 1992 |
Protective effects of chelating agents against renal toxicity of gold sodium thiomalate in rats.
Topics: Animals; Chelating Agents; Cysteine; Glycosuria; Gold Sodium Thiomalate; Kidney Diseases; Male; Penicillamine; Rats; Rats, Inbred Strains; Succimer; Unithiol | 1991 |
Effect of oral treatment with Bal, DMPS or DMSA arsenic in organs of mice injected with arsenic trioxide.
Topics: Administration, Oral; Animals; Arsenic; Arsenic Trioxide; Arsenicals; Dimercaprol; Male; Mice; Oxides; Succimer; Tissue Distribution; Unithiol | 1991 |
Determination and metabolism of dithiol chelating agents. VII. Biliary excretion of dithiols and their interactions with cadmium and metallothionein.
Topics: Animals; Bile; Cadmium; Cadmium Radioisotopes; Chelating Agents; Chromatography, High Pressure Liquid; Male; Metallothionein; Phthalic Acids; Rats; Rats, Inbred Strains; Succimer; Sulfhydryl Compounds; Ultrafiltration; Unithiol | 1990 |
Evaluation of the efficacy of dimercapto chelating agents for the treatment of systemic organic arsenic poisoning in rabbits.
Topics: Animals; Arsenic; Arsenic Poisoning; Arsenicals; Body Weight; Chelating Agents; Dimercaprol; Gallbladder; Lethal Dose 50; Liver; Lung; Male; Rats; Succimer; Unithiol | 1990 |
Efficacy of various dithiol compounds in acute As2O3 poisoning in mice.
Topics: Animals; Arsenic; Arsenic Trioxide; Arsenicals; Dimercaprol; Guinea Pigs; Male; Mice; Oxides; Succimer; Sulfhydryl Compounds; Unithiol | 1990 |
Relative binding constants of arsenical-antidote adducts determined by NMR spectroscopy.
Topics: Antidotes; Arsenicals; Dimercaprol; Magnetic Resonance Spectroscopy; Solvents; Stereoisomerism; Succimer; Unithiol | 1990 |
[Antidotal effects of sulfhydryl compounds on acute poisonings by sodium ammonium dimethyl-2-(propane-1,3-dithiosulfate) monohydrate, nereistoxin and cartap].
Topics: Animals; Cysteine; Dimercaprol; Female; Insecticides; Male; Marine Toxins; Mice; Rabbits; Saxitoxin; Succimer; Sulfhydryl Compounds; Thiocarbamates; Unithiol | 1990 |
Influence of 2,3-dimercaptopropane-1-sulfonate and dimercaptosuccinic acid on the mobilization of mercury from tissues of rats pretreated with mercuric chloride, phenylmercury acetate or mercury vapors.
Topics: Administration, Inhalation; Administration, Oral; Animals; Brain; Dimercaprol; Injections, Intraperitoneal; Injections, Intravenous; Kidney; Liver; Male; Mercuric Chloride; Mercury; Phenylmercuric Acetate; Phenylmercury Compounds; Rats; Rats, Inbred Strains; Succimer; Sulfhydryl Compounds; Unithiol | 1989 |
Determination and metabolism of dithiol chelating agents. IV. Urinary excretion of meso-2,3-dimercaptosuccinic acid and mercaptosuccinic acid in rabbits given meso-2,3-dimercaptosuccinic acid.
Topics: Animals; Biodegradation, Environmental; Chelating Agents; Chromatography, High Pressure Liquid; Injections, Intramuscular; Male; Rabbits; Sex Factors; Solvents; Succimer; Sulfhydryl Compounds; Thiomalates; Unithiol | 1989 |
Lack of effectiveness of D-penicillamine in experimental arsenic poisoning.
Topics: Animals; Arsenic; Arsenic Poisoning; Dimercaprol; Guinea Pigs; Male; Mice; Penicillamine; Succimer; Tissue Distribution; Unithiol | 1989 |
tri-n-Butyltin: a membrane toxicant.
Topics: Chemical Phenomena; Chemistry; Dimercaprol; Dithiothreitol; Dose-Response Relationship, Drug; Drug Interactions; Erythrocyte Membrane; Erythrocytes, Abnormal; Hemolysis; Humans; Microscopy, Electron; Spectrometry, X-Ray Emission; Succimer; Trialkyltin Compounds; Unithiol | 1987 |
Tissue decorporation of polonium-210 in rats by DMPA.
Topics: Animals; Chelating Agents; Male; Phthalic Acids; Polonium; Rats; Rats, Inbred Strains; Succimer; Sulfhydryl Compounds; Tissue Distribution; Unithiol | 1987 |
Dimercaptan metal-binding agents influence the biotransformation of arsenite in the rabbit.
Topics: Animals; Arsenic; Arsenites; Biotransformation; Chelating Agents; Chromatography, Ion Exchange; Male; Phthalic Acids; Rabbits; Succimer; Sulfhydryl Compounds; Unithiol | 1985 |
Antidotes for gold (sodium bis[thiosulfato]gold[I]) intoxication in mice.
Topics: Animals; Antidotes; Evaluation Studies as Topic; Gold; Gold Sodium Thiosulfate; Kidney; Lethal Dose 50; Liver; Male; Mice; Mice, Inbred ICR; Penicillamine; Succimer; Time Factors; Unithiol | 1985 |
Determination and metabolism of dithiol-chelating agents: electrolytic and chemical reduction of oxidized dithiols in urine.
Topics: Borohydrides; Chromatography, High Pressure Liquid; Dimercaprol; Dithiothreitol; Humans; Male; Oxidation-Reduction; Spectrometry, Fluorescence; Succimer; Sulfhydryl Compounds; Unithiol | 1987 |
Biological behavior and metabolic fate of the BAL analogues DMSA and DMPS.
Topics: Animals; Cricetinae; Dimercaprol; Dogs; Macaca mulatta; Male; Mice; Rats; Species Specificity; Succimer; Sulfhydryl Compounds; Time Factors; Unithiol | 1984 |
Protection of mice against the lethal effects of sodium arsenite by 2,3 dimercapto-1-propane-sulfonic acid and dimercaptosuccinic acid.
Topics: Animals; Arsenic; Arsenic Poisoning; Chelating Agents; Dimercaprol; Disease Models, Animal; Mice; Succimer; Sulfhydryl Compounds; Unithiol | 1980 |
The influence of chelating agents on the distribution and biotransformation of methylmercuric chloride in rats.
Topics: Animals; Biotransformation; Chelating Agents; Male; Methylmercury Compounds; Penicillamine; Rats; Succimer; Tissue Distribution; Unithiol | 1981 |
The effect of 2,3-dimercaptorpropane-1-sulfonate and dimercaptosuccinic acid on the distribution and excretion of mercuric chloride in rats.
Topics: Animals; Dimercaprol; Kidney; Male; Mercuric Chloride; Mercury; Rats; Succimer; Sulfhydryl Compounds; Tissue Distribution; Unithiol | 1981 |
Protection of mice against lethal effects of sodium arsenite--a quantitative comparison of a number of chelating agents.
Topics: Animals; Arsenic; Arsenites; Chelating Agents; Lethal Dose 50; Male; Mice; Sodium Compounds; Succimer; Sulfhydryl Compounds; Unithiol | 1981 |
Biological chelation: 2,3-dimercapto-propanesulfonic acid and meso-dimercaptosuccinic acid.
Topics: Animals; Arsenic Poisoning; Arsenites; Cadmium Poisoning; Chelating Agents; Dimercaprol; Lethal Dose 50; Male; Mice; Penicillamine; Sodium Compounds; Succimer; Sulfhydryl Compounds; Unithiol | 1982 |
Anti-lewisite activity and stability of meso-dimercaptosuccinic acid and 2,3-dimercapto-1-propanesulfonic acid.
Topics: Administration, Oral; Animals; Arsenic Poisoning; Arsenicals; Dimercaprol; Dose-Response Relationship, Drug; Drug Stability; Hydrogen-Ion Concentration; Injections, Subcutaneous; Male; Rabbits; Succimer; Unithiol | 1982 |
DMSA, DMPS, and DMPA--as arsenic antidotes.
Topics: Animals; Antidotes; Arsenates; Arsenic; Arsenic Poisoning; Arsenicals; Arsenites; Brain; Dimercaprol; Guinea Pigs; Male; Mice; Organ Size; Phthalic Acids; Pyruvate Dehydrogenase Complex; Rabbits; Sodium Compounds; Succimer; Sulfhydryl Compounds; Unithiol | 1984 |
Arsenic and copper excretion after treatment of arsenic poisoning in rats with heavy-metal antagonists.
Topics: Animals; Arsenic; Arsenic Poisoning; Chelating Agents; Copper; Dimercaprol; Male; Rats; Rats, Inbred Strains; Succimer; Sulfhydryl Compounds; Unithiol | 1983 |
Effect of various antidotes on the biliary and intestinal excretion of arsenic in situ and into the feces in vivo in guinea-pigs after injection of As2O3.
Topics: Animals; Antidotes; Arsenic; Arsenic Poisoning; Arsenic Trioxide; Arsenicals; Bile; Colon; Dimercaprol; Feces; Guinea Pigs; Injections, Intravenous; Jejunum; Male; Oxides; Perfusion; Poisoning; Succimer; Sulfonamides; Unithiol | 1994 |
Reversal of oxophenylarsine-induced inhibition of glucose uptake in MDCK cells.
Topics: Adenosine Triphosphate; Animals; Antidotes; Arsenic Poisoning; Arsenicals; Biological Transport; Cell Line; Dimercaprol; Dithiothreitol; Dogs; Enzyme Inhibitors; Glucose; L-Lactate Dehydrogenase; Mercaptoethanol; Succimer; Sulfonamides; Unithiol | 1995 |
Therapeutic potential of meso 2,3-dimercaptosuccinic acid or 2,3-dimercaptopropane 1-sulfonate in chronic arsenic intoxication in rats.
Topics: Animals; Arsenic Poisoning; Chronic Disease; Kidney Tubules; Liver; Male; Poisoning; Rats; Succimer; Unithiol | 1995 |
Effects of meso-2,3-dimercaptosuccinic acid or 2,3-dimercaptopropane 1-sulfonate on beryllium-induced biochemical alterations and metal concentration in male rats.
Topics: Animals; Beryllium; Feces; Kidney; Liver; Male; Poisoning; Rats; Succimer; Tissue Distribution; Unithiol | 1995 |
Efficacy of dimercapto chelating agents for the treatment of poisoning by percutaneously applied dichloro(2-chlorovinyl)arsine in rabbits.
Topics: Administration, Topical; Animals; Arsenic Poisoning; Arsenicals; Chelating Agents; Chemical and Drug Induced Liver Injury; Dimercaprol; Gallbladder; Lethal Dose 50; Liver; Lung; Male; Rabbits; Succimer; Sulfhydryl Compounds; Unithiol | 1993 |
Acute effects of the heavy metal antidotes DMPS and DMSA on circulation, respiration, and blood homoeostasis in dogs.
Topics: Animals; Blood Circulation; Dogs; Dose-Response Relationship, Drug; Erythrocytes; Female; Homeostasis; Injections, Intravenous; Male; Metals; Methemoglobin; Oxygen Consumption; Poisoning; Respiration; Succimer; Unithiol | 1993 |
Influence of 2,3-dimercaptopropane-1-sulfonate (DMPS) and meso-2,3-dimercaptosuccinic acid (DMSA) on the renal disposition of mercury in normal and uninephrectomized rats exposed to inorganic mercury.
Topics: Animals; Drug Evaluation, Preclinical; Feces; Injections, Intravenous; Kidney; Liver; Male; Mercuric Chloride; Mercury; Nephrectomy; Rats; Rats, Sprague-Dawley; Succimer; Time Factors; Unithiol | 1993 |
Arsenic and mercury intoxication due to Indian ethnic remedies.
Topics: Adult; Arsenic Poisoning; Humans; India; London; Male; Medicine, Traditional; Mercury Poisoning; Poisoning; Succimer; Unithiol | 1993 |
Isolated rat kidney tubules as a screening system for arsenic antidotes.
Topics: Animals; Antidotes; Arsenates; Arsenic; Arsenic Poisoning; Arsenicals; Arsenites; Chelating Agents; Dimercaprol; Drug Evaluation, Preclinical; Gluconeogenesis; In Vitro Techniques; Kidney Tubules; Male; Mice; Mice, Inbred Strains; Rats; Rats, Sprague-Dawley; Succimer; Unithiol | 1993 |
meso-2,3-dimercaptosuccinic acid monoalkyl esters: effects on mercury levels in mice.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Esters; Male; Mercury; Mercury Poisoning; Mice; Succimer; Unithiol | 1993 |
Comparative evaluation of chelating agents on the mobilization of cadmium: a mechanistic approach.
Topics: Animals; Cadmium; Chelating Agents; Dimethyldithiocarbamate; Female; Lethal Dose 50; Mice; Solubility; Succimer; Tissue Distribution; Unithiol | 1996 |
Clinical course of severe poisoning with thiomersal.
Topics: Administration, Oral; Adult; Animals; Anti-Infective Agents, Local; Chelating Agents; Humans; Kidney; Lethal Dose 50; Male; Mercury; Rats; Succimer; Suicide, Attempted; Thimerosal; Unithiol | 1996 |
Increased inorganic mercury in spinal motor neurons following chelating agents.
Topics: Animals; Chelating Agents; Female; Mercuric Chloride; Mice; Mice, Inbred BALB C; Motor Neurons; Succimer; Unithiol | 1996 |
Evaluation of dithiol chelating agents as potential adjuvants for anti-IL-2 receptor lead or bismuth alpha radioimmunotherapy.
Topics: Adjuvants, Immunologic; Animals; Bismuth; Cell Division; Cell Survival; Chelating Agents; Female; Flow Cytometry; Indicators and Reagents; Lead; Lead Radioisotopes; Mice; Mice, Nude; Radioimmunotherapy; Radioisotopes; Rats; Receptors, Interleukin-2; Succimer; Sulfhydryl Compounds; Tumor Cells, Cultured; Unithiol | 1996 |
Utilization of renal slices to evaluate the efficacy of chelating agents for removing mercury from the kidney.
Topics: Animals; Antidotes; Chelating Agents; Dithiothreitol; Drug Evaluation, Preclinical; Edetic Acid; Evaluation Studies as Topic; Glutathione; Kidney; Male; Mercuric Chloride; Mercury; Penicillamine; Rabbits; Succimer; Thioctic Acid; Unithiol | 1997 |
Effects of some thiol chelators on enzymatic activities in blood, liver and kidneys of acute arsenic (III) exposed mice.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Arsenites; Aspartate Aminotransferases; Chelating Agents; gamma-Glutamyltransferase; Kidney; Liver; Male; Mice; Porphobilinogen Synthase; S-Adenosylmethionine; Sodium Compounds; Structure-Activity Relationship; Succimer; Unithiol | 1998 |
Antidotal effects of 2,3-dimercaptopropane-1-sulfonic acid (DMPS) and meso-2,3-dimercaptosuccinic acid (DMSA) on the organotoxicity of dibutyltin dichloride (DBTC) in rats.
Topics: Alkaline Phosphatase; Amylases; Animals; Antidotes; Bile; Bile Ducts; Bilirubin; Chelating Agents; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Hyaluronic Acid; Lipase; Liver; Liver Cirrhosis, Experimental; Male; Organ Size; Organotin Compounds; Pancreas; Pancreatitis; Rats; Rats, Inbred Lew; Succimer; Thymus Gland; Tin; Unithiol | 2000 |
BAL modulates glutamate transport in synaptosomes and synaptic vesicles from rat brain.
Topics: Animals; Biological Transport; Brain; Chelating Agents; Dimercaprol; Glutamic Acid; In Vitro Techniques; Male; Potassium; Rats; Rats, Wistar; Succimer; Synaptosomes; Tritium; Unithiol | 2001 |
Effects of Lewisite on cell membrane integrity and energy metabolism in human keratinocytes and SCL II cells.
Topics: Adenosine Triphosphate; Arsenicals; Cell Membrane Permeability; Cell Survival; Chelating Agents; Energy Metabolism; Formazans; Glucose; Humans; Keratinocytes; L-Lactate Dehydrogenase; Lactic Acid; Succimer; Tetrazolium Salts; Time Factors; Tumor Cells, Cultured; Unithiol | 2001 |
Chelation therapy in children exposed to lead.
Topics: Chelating Agents; Chelation Therapy; Child; Humans; Lead; Lead Poisoning; Penicillamine; Succimer; Unithiol | 2001 |
Effect of dithiol chelating agents on [3H]MK-801 and [3H]glutamate binding to synaptic plasma membranes.
Topics: Animals; Chelating Agents; Dimercaprol; Dithiothreitol; Dizocilpine Maleate; Glutamic Acid; Male; Rats; Rats, Wistar; Succimer; Synaptic Membranes; Tritium; Unithiol | 2001 |
The renal Na(+)-dependent dicarboxylate transporter, NaDC-3, translocates dimethyl- and disulfhydryl-compounds and contributes to renal heavy metal detoxification.
Topics: Animals; Biological Transport; Dicarboxylic Acid Transporters; Disulfides; Female; Fishes; Inactivation, Metabolic; Kidney; Metals, Heavy; Oocytes; Patch-Clamp Techniques; Succimer; Succinates; Sulfonic Acids; Unithiol; Xenopus laevis | 2002 |
2,3-Dimercaptopropane-1-sulfonic acid and meso-2,3-dimercaptosuccinic acid increase mercury- and cadmium-induced inhibition of delta-aminolevulinate dehydratase.
Topics: Animals; Cadmium; Chelating Agents; Drug Synergism; Enzyme Inhibitors; Lead; Male; Mercury; Mice; Polarography; Porphobilinogen Synthase; Succimer; Unithiol; Zinc | 2003 |
Metal chelators change the human sperm motility pattern.
Topics: Chelating Agents; Dose-Response Relationship, Drug; Humans; Male; Penicillamine; Prospective Studies; Sperm Motility; Spermatozoa; Succimer; Unithiol | 2003 |
Vitamin C, glutathione, or lipoic acid did not decrease brain or kidney mercury in rats exposed to mercury vapor.
Topics: Administration, Inhalation; Animals; Antioxidants; Ascorbic Acid; Brain; Chelating Agents; Drug Therapy, Combination; Glutathione; Kidney; Male; Mercury Poisoning; Rats; Rats, Sprague-Dawley; Succimer; Thioctic Acid; Unithiol; Volatilization | 2003 |
2,3-Dimercaptopropanol, 2,3-dimercaptopropane-1-sulfonic acid, and meso-2,3-dimercaptosuccinic acid inhibit delta-aminolevulinate dehydratase from human erythrocytes in vitro.
Topics: Chelating Agents; Chlorides; Cysteine; Dimercaprol; Dithiothreitol; Dose-Response Relationship, Drug; Erythrocytes; Humans; In Vitro Techniques; Porphobilinogen Synthase; Reducing Agents; Succimer; Unithiol; Zinc Compounds | 2004 |
Mercury binding to the chelation therapy agents DMSA and DMPS and the rational design of custom chelators for mercury.
Topics: Chelating Agents; Chelation Therapy; Mercury; Mercury Poisoning; Spectrum Analysis; Succimer; Unithiol | 2004 |
Lead-induced oxidative stress and hematological alterations and their response to combined administration of calcium disodium EDTA with a thiol chelator in rats.
Topics: Animals; Brain; Chelating Agents; Drug Therapy, Combination; Edetic Acid; Glutathione; Hemoglobins; Kidney; Lead; Lead Poisoning; Male; Metals; Oxidative Stress; Porphobilinogen Synthase; Protoporphyrins; Rats; Rats, Wistar; Succimer; Unithiol | 2004 |
Simultaneous administration of sodium selenite and mercuric chloride decreases efficacy of DMSA and DMPS in mercury elimination in rats.
Topics: Animals; Antidotes; Body Weight; Chelating Agents; Female; Kidney; Liver; Mercuric Chloride; Mercury; Organ Size; Proteins; Rats; Rats, Wistar; Selenium; Selenoproteins; Sodium Selenite; Spectrophotometry, Atomic; Succimer; Unithiol | 2005 |
2,3-Dimercaptopropanol, 2,3-dimercaptopropane-1-sulfonic acid and meso-2,3-dimercaptosuccinic acid acute administration diferentially change biochemical parameters in mice.
Topics: Aminolevulinic Acid; Animals; Brain Chemistry; Dimercaprol; Epilepsy, Tonic-Clonic; Injections, Subcutaneous; Kidney; Liver; Male; Mice; Succimer; Sulfhydryl Compounds; Time Factors; Toxicity Tests, Acute; Unithiol; Zinc | 2005 |
Efforts to control the errant products of a targeted in vivo generator.
Topics: Actinium; Alpha Particles; Animals; Antibodies, Monoclonal; Bismuth; Chelating Agents; Female; Francium; Immunotoxins; Kidney; Lymphoma; Macaca fascicularis; Male; Mice; Mice, Inbred BALB C; Mice, SCID; Radioimmunotherapy; Succimer; Unithiol | 2005 |
Arsenic induced blood and brain oxidative stress and its response to some thiol chelators in rats.
Topics: 5-Aminolevulinate Synthetase; Animals; Arsenic; Arsenic Poisoning; Chelating Agents; DNA Damage; Glutathione; Glutathione Peroxidase; Glutathione Transferase; Male; Oxidative Stress; Porphobilinogen Synthase; Rats; Rats, Wistar; Reactive Oxygen Species; Succimer; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Unithiol | 2005 |
2,3-Dimercaptopropanol, 2,3-dimercaptopropane-1-sulfonic acid and meso-2,3-dimercaptosuccinic acid increase lead-induced inhibition of delta-aminolevulinate dehydratase in vitro and ex vivo.
Topics: Animals; Brain; Chelating Agents; Dimercaprol; Drug Synergism; Enzyme Inhibitors; Humans; In Vitro Techniques; Kidney; Lead; Liver; Male; Mice; Nerve Tissue Proteins; Porphobilinogen Synthase; Succimer; Unithiol | 2006 |
Dithiol compounds at low concentrations increase arsenite toxicity.
Topics: Apoptosis; Arsenites; Cell Line, Tumor; Cell Nucleus; Cell Survival; Dithiothreitol; DNA Damage; Drug Interactions; Glutathione; Humans; Hydrogen Peroxide; Micronuclei, Chromosome-Defective; Succimer; Sulfhydryl Compounds; Unithiol | 2006 |
Neither DMPS nor DMSA is effective in quantitative elimination of elemental mercury after intentional IV injection.
Topics: Adult; Chelating Agents; Colon; Heart Ventricles; Humans; Injections, Intravenous; Kidney; Liver; Lung; Male; Mercury; Mercury Poisoning; Radiography; Succimer; Suicide, Attempted; Unithiol | 2006 |
Cadmium inhibits delta-aminolevulinate dehydratase from rat lung in vitro: interaction with chelating and antioxidant agents.
Topics: Acetylcysteine; Animals; Antioxidants; Ascorbic Acid; Benzene Derivatives; Cadmium Chloride; Chelating Agents; Chlorides; Dithiothreitol; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Environmental Pollutants; Enzyme Inhibitors; Lung; Male; Organoselenium Compounds; Porphobilinogen Synthase; Rats; Rats, Wistar; Succimer; Unithiol; Zinc Compounds | 2007 |
Multidrug resistance proteins and the renal elimination of inorganic mercury mediated by 2,3-dimercaptopropane-1-sulfonic acid and meso-2,3-dimercaptosuccinic acid.
Topics: Animals; ATP-Binding Cassette Transporters; Chelating Agents; Feces; Kidney; Liver; Male; Mercury; Rats; Rats, Wistar; Succimer; Unithiol | 2008 |
MRP2 and the DMPS- and DMSA-mediated elimination of mercury in TR(-) and control rats exposed to thiol S-conjugates of inorganic mercury.
Topics: Animals; ATP-Binding Cassette Transporters; Body Burden; Chelating Agents; Cysteine; Homocysteine; Kidney; Liver; Male; Mercury; Rats; Rats, Wistar; Succimer; Unithiol | 2008 |
Effects of chelators on mercury, iron, and lead neurotoxicity in cortical culture.
Topics: Animals; Brain Chemistry; Cell Death; Cells, Cultured; Cerebral Cortex; Chelating Agents; Drug Synergism; Edetic Acid; Female; Iron; Lead; Mercuric Chloride; Methylmercury Compounds; Mice; Penicillamine; Pregnancy; Succimer; Thimerosal; Unithiol | 2009 |
MRP2 involvement in renal proximal tubular elimination of methylmercury mediated by DMPS or DMSA.
Topics: Animals; ATP-Binding Cassette Transporters; Brain; Brain Chemistry; Cell Line; Feces; Gene Expression Regulation; Insecta; Kidney; Liver; Male; Mercury; Methylmercury Compounds; Multidrug Resistance-Associated Protein 2; Rats; Rats, Wistar; Succimer; Unithiol | 2009 |
Mechanism of thiol-supported arsenate reduction mediated by phosphorolytic-arsenolytic enzymes: I. The role of arsenolysis.
Topics: Acetyl Coenzyme A; Animals; Arsenates; Arsenites; Bacterial Proteins; Cattle; Dithiothreitol; Glutathione; Glyceraldehyde-3-Phosphate Dehydrogenases; Glycogen Phosphorylase; Inosine; Kinetics; Mercaptoethanol; Models, Chemical; Oxidation-Reduction; Phosphate Acetyltransferase; Purine-Nucleoside Phosphorylase; Rabbits; Sodium Compounds; Succimer; Sulfhydryl Compounds; Unithiol | 2009 |
Mechanism of thiol-supported arsenate reduction mediated by phosphorolytic-arsenolytic enzymes: II. Enzymatic formation of arsenylated products susceptible for reduction to arsenite by thiols.
Topics: Acetyl Coenzyme A; Animals; Arsenates; Arsenites; Bacterial Proteins; Cattle; Dithiothreitol; Enzyme Inhibitors; Glutathione; Glyceraldehyde-3-Phosphate Dehydrogenases; Glycogen Phosphorylase; Half-Life; Inosine; Kinetics; Mercaptoethanol; Models, Chemical; Oxidation-Reduction; Phosphate Acetyltransferase; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Rabbits; Sodium Compounds; Succimer; Sulfhydryl Compounds; Unithiol | 2009 |
Effect of DMPS and DMSA on the placental and fetal disposition of methylmercury.
Topics: Animals; Brain; Brain Chemistry; Chelating Agents; Female; Fetal Weight; Fetus; Gestational Age; Hazardous Substances; Injections, Intravenous; Kidney; Liver; Maternal Exposure; Maternal-Fetal Exchange; Mercury; Methylmercury Compounds; Organ Size; Placenta; Pregnancy; Random Allocation; Rats; Rats, Wistar; Succimer; Tissue Distribution; Unithiol | 2009 |
Study of the Hg2+ binding with chelation therapy agents by differential pulse voltammetry on rotating Au-disk electrode and electrospray ionization mass-spectrometry.
Topics: Chelating Agents; Chelation Therapy; Electrodes; Gold; Least-Squares Analysis; Mercury; Penicillamine; Spectrometry, Mass, Electrospray Ionization; Succimer; Unithiol | 2009 |
Mercury in pediatric poisoning.
Topics: Chelating Agents; Child; Female; Humans; Mercury Poisoning; Succimer; Unithiol | 2010 |
Fatal mercury poisoning and chelating agents.
Topics: Chelating Agents; Dimercaprol; Edetic Acid; Humans; Male; Mercury Poisoning; Succimer; Suicide; Unithiol | 2010 |
Blood, urine, and hair kinetic analysis following an acute lead intoxication.
Topics: Chelating Agents; Chelation Therapy; Female; Hair; Humans; Kinetics; Lead; Lead Poisoning; Middle Aged; Succimer; Unithiol | 2011 |
Influence of glutathione chemical effectors in the response of maize to arsenic exposure.
Topics: Arsenates; Arsenic; Arsenites; Biological Transport; Biomass; Buthionine Sulfoximine; Chelating Agents; Enzyme Inhibitors; Glutathione; Glutathione Transferase; Hydroponics; Phytochelatins; Plant Roots; Plant Shoots; Seedlings; Succimer; Sulfhydryl Compounds; Thiazoles; Unithiol; Zea mays | 2012 |
In vitro assessment of chelating agents with regard to their abstraction efficiency of Cd(2+) bound to plasma proteins.
Topics: Acetylcysteine; Animals; Blood Proteins; Cadmium; Calcium; Chelating Agents; Chromatography, Gel; Humans; Rabbits; Spectrophotometry, Atomic; Succimer; Unithiol; Zinc | 2012 |
Electroanalytical and isothermal calorimetric study of As(III) complexation by the metal poisoning remediators, 2,3-dimercapto-1-propanesulfonate and meso-2,3-dimercaptosuccinic acid.
Topics: Arsenates; Arsenic Poisoning; Calorimetry; Chelating Agents; Electrochemical Techniques; Heavy Metal Poisoning; Humans; Least-Squares Analysis; Metals, Heavy; Normal Distribution; Poisoning; Spectrometry, Mass, Electrospray Ionization; Succimer; Unithiol | 2012 |
Structural characterization of Cd²⁺ complexes in solution with DMSA and DMPS.
Topics: Cadmium Compounds; Chelating Agents; Chromatography, Gel; Coordination Complexes; Models, Molecular; Molecular Conformation; Solutions; Spectrophotometry, Atomic; Succimer; Unithiol; X-Ray Absorption Spectroscopy | 2014 |
Nanoparticles modulate autophagic effect in a dispersity-dependent manner.
Topics: Adenine; Autophagy; Carboxylic Acids; Cell Line, Tumor; Citrates; Gold; HeLa Cells; Humans; Lysosomal Membrane Proteins; Metal Nanoparticles; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Silver; Sodium Citrate; Succimer; Surface Properties; Suspensions; Unithiol; Up-Regulation | 2015 |
The effects of 2,3-dimercapto-1-propanesulfonic acid (DMPS) and meso-2,3-dimercaptosuccinic acid (DMSA) on the nephrotoxicity in the mouse during repeated cisplatin (CDDP) treatments.
Topics: Animals; Antineoplastic Agents; Cisplatin; Dose-Response Relationship, Drug; Female; Kidney; Kidney Diseases; Mice; Organic Cation Transport Proteins; Organic Cation Transporter 2; RNA, Messenger; Succimer; Unithiol | 2017 |