undecaprenyl-phosphate has been researched along with dolichol-monophosphate* in 2 studies
1 review(s) available for undecaprenyl-phosphate and dolichol-monophosphate
| Article | Year |
|---|---|
From peptidoglycan to glycoproteins: common features of lipid-linked oligosaccharide biosynthesis.
The peptidoglycan layer of bacterial cell walls is biosynthesised using a lipid carrier undecaprenyl phosphate to assemble and transport the MurNAc(GlcNAc)-pentapeptide precursor. Similar lipid-linked cycles are involved in the biosynthesis of other bacterial exopolysaccharides and eukaryotic asparagine-linked glycoproteins, the latter involving the structurally related dolichyl phosphate as a lipid carrier. Recent protein sequence data and common inhibitors of the bacterial and eukaryotic systems have revealed functional similarities between the two systems. Biological and physical studies on the lipid carriers themselves have provided clues to their role in oligosaccharide translocation, but have not revealed significant differences in function between undecaprenyl phosphate and dolichyl phosphate. The presence of dolichyl phosphate and a family of saturated isoprenoid lipids in Archaebacteria suggests a possible evolutionary link between the two systems. Topics: Amino Acid Sequence; Bacteria; Dolichol Phosphates; Membrane Glycoproteins; Molecular Sequence Data; Peptidoglycan; Polyisoprenyl Phosphates | 1994 |
1 other study(ies) available for undecaprenyl-phosphate and dolichol-monophosphate
| Article | Year |
|---|---|
Glycoprotein biosynthesis in Chlamydomonas. A mannolipid intermediate with the properties of a short-chain alpha-saturated polyprenyl monophosphate.
A crude membrane preparation of the unicellular green alga Chlamydomonas reinhardii was found to catalyse the incorporation of D-[14C]mannose from GDP-D-[14C]-mannose into a chloroform/methanol-soluble compound and into a trichloroacetic acid-insoluble polymer fraction. The labelled lipid revealed the chemical and chromatographic properties of a short-chain (about C55-C65) alpha-saturated polyprenyl mannosyl monophosphate. In the presence of detergent both long-chain (C85-C105) dolichol phosphate and alpha-unsaturated undecaprenyl phosphate (C55) were found to be effective as exogenous acceptors of D-mannose from GDP-D-[14C]mannose to yield their corresponding labelled polyprenyl mannosyl phosphates. Exogenous dolichyl phosphate stimulated the incorporation of mannose from GDP-D-[14C]mannose into the polymer fraction 5-7-fold, whereas the mannose moiety from undecaprenyl mannosyl phosphate was not further transferred. Authentic dolichyl phosphate [3H]mannose and partially purified mannolipid formed from GDP-[14C]mannose and exogenous dolichyl phosphate were found to function as direct mannosyl donors for the synthesis of labelled mannoproteins. These results clearly indicate the existence of dolichol-type glycolipids and their role as intermediates in transglycosylation reactions of this algal system. Both the saturation of the alpha-isoprene unit and the length of the polyprenyl chain may be regarded as evolutionary markers. Topics: Chlamydomonas; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chromatography, Thin Layer; Dolichol Monophosphate Mannose; Dolichol Phosphates; Glycoproteins; Hydrolysis; Mannose; Membrane Glycoproteins; Polyisoprenyl Phosphate Sugars; Polyisoprenyl Phosphates | 1984 |