Page last updated: 2024-08-25

uk 68798 and verapamil

uk 68798 has been researched along with verapamil in 39 studies

Research

Studies (39)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (7.69)18.2507
2000's18 (46.15)29.6817
2010's16 (41.03)24.3611
2020's2 (5.13)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Cavalli, A; De Ponti, F; Poluzzi, E; Recanatini, M1
Chen, XL; Hendrix, J; Kang, J; Korolev, AM; Lysenkova, LN; Miroshnikova, OV; Pearlstein, RA; Preobrazhenskaya, M; Rampe, D; Shchekotikhin, AE; Vaz, RJ1
Keserü, GM1
Du, LP; Li, MY; Tsai, KC; Xia, L; You, QD1
Nagashima, R; Nishikawa, T; Tobita, M1
Lombardo, F; Obach, RS; Waters, NJ1
Jia, L; Sun, H1
Caron, G; Ermondi, G; Visentin, S1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Cooper, J; Cui, Y; Fink, M; Gavaghan, DJ; Heath, BM; McMahon, NC; Mirams, GR; Noble, D; Sher, A1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Fijorek, K; Glinka, A; Mendyk, A; Polak, S; Wiśniowska, B1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Brown, AM; Bruening-Wright, A; Kramer, J; Kuryshev, YA; Myatt, G; Obejero-Paz, CA; Verducci, JS1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Dubrovskyi, O; Dye, K; Gutgesell, LM; Huang, F; Li, Y; Ratia, K; Shen, Z; Thatcher, GRJ; Tonetti, DA; Xiong, R; Zhao, H; Zhao, J1
De Clerck, F; Lu, HR; Remeysen, P1
Duff, HJ; Exner, DV; Feng, ZP; Geonzon, R; Wang, L; Woodman, RC1
Gong, Q; January, CT; Makielski, JC; Zhang, S; Zhou, Z1
Cheng, SL; Johnson, BF; Venitz, J1
Dai, DZ; Kong, RZ; Li, HT; Wang, YQ1
Khan, IA2
Andreas, JO; Hauser, R; Jahnel, U; Linz, K; Schneider, J1
Hamlin, RL; Keene, BW; Kijtawornrat, A; Nishijima, Y; Roche, BM1
Hreiche, R; Morissette, P; Turgeon, J; Zakrzewski-Jakubiak, H1
Du, JR; Li, ML; Yang, Y; Zeng, XR1
Antoons, G; Attevelt, NJ; Beekman, JD; Belardinelli, L; Gomez, AM; Houtman, MJ; Neco, P; Oosterhoff, P; Oros, A; Rajamani, S; Richard, S; van der Heyden, MA; Ver Donck, L; Vos, MA1
Florian, J; Galeotti, L; Guo, P; Hong, M; Johannesen, L; Lin, J; Mason, JW; Sanabria, C; Stockbridge, N; Strauss, DG; Sørensen, JS; Ugander, M; Vicente, J; Waite-Labott, K1
Haigney, MC1
Crumb, WJ; Johannesen, L; Mason, JW; Pueyo, E; Stockbridge, N; Strauss, DG; Vicente, J1
Brown, AM; Bruening-Wright, A; Dittrich, HC; Hawryluk, P; Kramer, J; Obejero-Paz, CA; Tatalovic, M1
Hosseini, M; Johannesen, L; Mason, JW; Pueyo, E; Sager, PT; Strauss, DG; Vicente, J1
Árpádffy-Lovas, T; Gazdag, P; Geramipour, A; Jost, N; Kohajda, Z; Orvos, P; Szlovák, J; Tálosi, L; Tóth, D; Varró, A; Virág, L1
Bergau, D; Bystricky, W; Carter, D; Gintant, G; Kamradt, K; Maier, C; Welsh, P1
Bai, S; Cao, H; Chen, K; Dong, H; Ma, Y; Pei, J; Tian, L; Zhao, Y1

Reviews

3 review(s) available for uk 68798 and verapamil

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Transient atrial mechanical dysfunction (stunning) after cardioversion of atrial fibrillation and flutter.
    American heart journal, 2002, Volume: 144, Issue:1

    Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Appendage; Atrial Fibrillation; Atrial Flutter; Catheter Ablation; Dogs; Electric Countershock; Heart Atria; Humans; Myocardial Contraction; Myocardial Stunning; Phenethylamines; Regional Blood Flow; Sotalol; Sulfonamides; Ultrasonography; Verapamil

2002
Atrial stunning: basics and clinical considerations.
    International journal of cardiology, 2003, Volume: 92, Issue:2-3

    Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Atrial Function; Atrial Function, Left; Atrial Function, Right; Catheter Ablation; Electric Countershock; Humans; Isoproterenol; Myocardial Stunning; Phenethylamines; Sotalol; Sulfonamides; Thromboembolism; Time Factors; Verapamil

2003

Trials

5 trial(s) available for uk 68798 and verapamil

ArticleYear
Transient kinetic and dynamic interactions between verapamil and dofetilide, a class III antiarrhythmic.
    Journal of clinical pharmacology, 2001, Volume: 41, Issue:11

    Topics: Adult; Anti-Arrhythmia Agents; Area Under Curve; Calcium Channel Blockers; Drug Interactions; Humans; Kidney; Liver; Male; Metabolic Clearance Rate; Phenethylamines; Potassium Channel Blockers; Sulfonamides; Verapamil

2001
Differentiating drug-induced multichannel block on the electrocardiogram: randomized study of dofetilide, quinidine, ranolazine, and verapamil.
    Clinical pharmacology and therapeutics, 2014, Volume: 96, Issue:5

    Topics: Acetanilides; Calcium Channel Blockers; Electrocardiography; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Heart Rate; Humans; Phenethylamines; Piperazines; Potassium Channel Blockers; Prospective Studies; Quinidine; Ranolazine; Sodium Channel Blockers; Sulfonamides; Verapamil

2014
Comprehensive T wave morphology assessment in a randomized clinical study of dofetilide, quinidine, ranolazine, and verapamil.
    Journal of the American Heart Association, 2015, Apr-13, Volume: 4, Issue:4

    Topics: Adult; Calcium Channel Blockers; Cross-Over Studies; Electrocardiography; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Female; Heart; Humans; Long QT Syndrome; Male; Phenethylamines; Quinidine; Ranolazine; Sodium Channel Blockers; Sulfonamides; Verapamil

2015
Electrocardiographic Biomarkers for Detection of Drug-Induced Late Sodium Current Block.
    PloS one, 2016, Volume: 11, Issue:12

    Topics: Adult; Biomarkers; Calcium Channel Blockers; Cross-Over Studies; Electrocardiography; Ether-A-Go-Go Potassium Channels; Female; Heart; Heart Rate; Humans; Lidocaine; Long QT Syndrome; Male; Mexiletine; Phenethylamines; Potassium Channel Blockers; Sodium; Sodium Channel Blockers; Sulfonamides; Torsades de Pointes; Verapamil

2016
T vector velocity: A new ECG biomarker for identifying drug effects on cardiac ventricular repolarization.
    PloS one, 2019, Volume: 14, Issue:7

    Topics: Action Potentials; Adult; Databases, Factual; Double-Blind Method; Electrocardiography; Female; Heart; Humans; Lidocaine; Male; Mexiletine; Phenethylamines; Potassium Channel Blockers; Ranolazine; Sodium Channel Blockers; Sulfonamides; Verapamil; Young Adult

2019

Other Studies

31 other study(ies) available for uk 68798 and verapamil

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers.
    Journal of medicinal chemistry, 2002, Aug-29, Volume: 45, Issue:18

    Topics: Anti-Arrhythmia Agents; Cation Transport Proteins; Cluster Analysis; Databases, Factual; Ether-A-Go-Go Potassium Channels; Long QT Syndrome; Models, Molecular; Molecular Conformation; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship

2002
Characterization of HERG potassium channel inhibition using CoMSiA 3D QSAR and homology modeling approaches.
    Bioorganic & medicinal chemistry letters, 2003, May-19, Volume: 13, Issue:10

    Topics: Amino Acids, Aromatic; Cation Transport Proteins; DNA-Binding Proteins; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Hydrophobic and Hydrophilic Interactions; Imidazoles; Indoles; Inhibitory Concentration 50; Models, Molecular; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Protein Binding; Protein Conformation; Quantitative Structure-Activity Relationship; Structural Homology, Protein; Structure-Activity Relationship; Trans-Activators; Transcriptional Regulator ERG

2003
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
    Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16

    Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship

2003
The pharmacophore hypotheses of I(Kr) potassium channel blockers: novel class III antiarrhythmic agents.
    Bioorganic & medicinal chemistry letters, 2004, Sep-20, Volume: 14, Issue:18

    Topics: Anti-Arrhythmia Agents; Models, Biological; Models, Molecular; Potassium Channel Blockers; Potassium Channels; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical

2004
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
    Bioorganic & medicinal chemistry letters, 2005, Jun-02, Volume: 15, Issue:11

    Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated

2005
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Support vector machines classification of hERG liabilities based on atom types.
    Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11

    Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve

2008
GRIND-based 3D-QSAR and CoMFA to investigate topics dominated by hydrophobic interactions: the case of hERG K+ channel blockers.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:5

    Topics: Ether-A-Go-Go Potassium Channels; Humans; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Potassium Channel Blockers; Quantitative Structure-Activity Relationship

2009
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk.
    Cardiovascular research, 2011, Jul-01, Volume: 91, Issue:1

    Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Computer Simulation; Dogs; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Guinea Pigs; HEK293 Cells; Humans; Ion Channels; Kinetics; Models, Cardiovascular; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Potassium Channel Blockers; Rabbits; Risk Assessment; Risk Factors; Sodium Channel Blockers; Sodium Channels; Torsades de Pointes; Transfection

2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment.
    Journal of applied toxicology : JAT, 2012, Volume: 32, Issue:10

    Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computational Biology; Computer Simulation; Drugs, Investigational; Ether-A-Go-Go Potassium Channels; Expert Systems; Heart Rate; Humans; Models, Biological; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Potassium Channel Blockers; Quantitative Structure-Activity Relationship; Risk Assessment; Shaker Superfamily of Potassium Channels; Torsades de Pointes; Voltage-Gated Sodium Channel Blockers

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
MICE models: superior to the HERG model in predicting Torsade de Pointes.
    Scientific reports, 2013, Volume: 3

    Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Theoretical; Patch-Clamp Techniques; Predictive Value of Tests; Torsades de Pointes

2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER+ Breast Cancer with Acquired Resistance to Fulvestrant and Palbociclib.
    Journal of medicinal chemistry, 2020, 07-09, Volume: 63, Issue:13

    Topics: Animals; Breast Neoplasms; Drug Resistance, Neoplasm; Fulvestrant; Humans; MCF-7 Cells; Mice; Models, Molecular; Piperazines; Protein Domains; Pyridines; Pyridones; Receptors, Estrogen; Tissue Distribution; Transcription Factors; Xenograft Model Antitumor Assays

2020
Antifibrillary action of class I-IV antiarrhythmic agents in the model of ventricular fibrillation threshold of anesthetized guinea pigs.
    Journal of cardiovascular pharmacology, 1995, Volume: 26, Issue:1

    Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Atenolol; Benzopyrans; Chromans; Disease Models, Animal; Electric Stimulation; Electrocardiography; Encainide; Ethanolamines; Guinea Pigs; Heart; Heart Conduction System; Injections, Intravenous; Male; Metoprolol; Nebivolol; Phenethylamines; Piperidines; Sotalol; Sulfonamides; Ventricular Fibrillation; Verapamil

1995
A high affinity binding site for [3H]-Dofetilide on human leukocytes.
    Journal of molecular and cellular cardiology, 1998, Volume: 30, Issue:9

    Topics: Animals; Anti-Arrhythmia Agents; Binding Sites; Charybdotoxin; Guinea Pigs; Humans; Kinetics; Leukocytes; Neuropeptides; Neutrophils; Phenethylamines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Shaw Potassium Channels; Sulfonamides; Tetraethylammonium; Verapamil

1998
Mechanism of block and identification of the verapamil binding domain to HERG potassium channels.
    Circulation research, 1999, May-14, Volume: 84, Issue:9

    Topics: Anti-Arrhythmia Agents; Calcium Channel Blockers; Cation Transport Proteins; Cell Line; Diltiazem; DNA-Binding Proteins; Electric Conductivity; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Hydrogen-Ion Concentration; Intracellular Membranes; Mutation; Nifedipine; Phenethylamines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Sulfonamides; Trans-Activators; Transcriptional Regulator ERG; Verapamil

1999
Frequency dependent prolongation of effective refractory period by a complex class III antiarrhythmic agent CPU-86017.
    Acta pharmacologica Sinica, 2001, Volume: 22, Issue:1

    Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Benzeneacetamides; Berberine; Calcium Channel Blockers; Female; Guinea Pigs; Heart Atria; In Vitro Techniques; Male; Papillary Muscles; Phenethylamines; Piperidines; Potassium Channel Blockers; Refractory Period, Electrophysiological; Sulfonamides; Verapamil

2001
Differential effects of human ether-a-go-go-related gene (HERG) blocking agents on QT duration variability in conscious dogs.
    European journal of pharmacology, 2005, Apr-04, Volume: 512, Issue:1

    Topics: Animals; Calcium Channel Blockers; Dogs; Electrocardiography; Ether-A-Go-Go Potassium Channels; Humans; Male; Phenethylamines; Potassium Channels; Sotalol; Sulfonamides; Torsades de Pointes; Verapamil

2005
Use of a failing rabbit heart as a model to predict torsadogenicity.
    Toxicological sciences : an official journal of the Society of Toxicology, 2006, Volume: 93, Issue:1

    Topics: Amiodarone; Animals; Cardiac Output, Low; Cisapride; Dose-Response Relationship, Drug; Electrocardiography; Models, Animal; Phenethylamines; Quaternary Ammonium Compounds; Quinidine; Rabbits; Sulfonamides; Torsades de Pointes; Verapamil

2006
Gender-related differences in drug-induced prolongation of cardiac repolarization in prepubertal guinea pigs.
    Journal of cardiovascular pharmacology and therapeutics, 2009, Volume: 14, Issue:1

    Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Delayed Rectifier Potassium Channels; Domperidone; Female; Guinea Pigs; Heart Conduction System; Indapamide; Long QT Syndrome; Male; Phenethylamines; Potassium Channel Blockers; Sex Factors; Sexual Development; Sulfonamides; Time Factors; Verapamil

2009
[Effects of combined use of dofetilide and verapamil on the action potential of papillary muscles in guinea pigs].
    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2009, Volume: 40, Issue:5

    Topics: Action Potentials; Animals; Calcium Channel Blockers; Drug Synergism; Female; Guinea Pigs; In Vitro Techniques; Male; Microelectrodes; Papillary Muscles; Phenethylamines; Potassium Channel Blockers; Sulfonamides; Verapamil

2009
Robust anti-arrhythmic efficacy of verapamil and flunarizine against dofetilide-induced TdP arrhythmias is based upon a shared and a different mode of action.
    British journal of pharmacology, 2010, Volume: 161, Issue:1

    Topics: Animals; Anti-Arrhythmia Agents; Calcium Signaling; Cell Line; Dogs; Flunarizine; Humans; Lidocaine; Mice; Myocytes, Cardiac; Phenethylamines; Sulfonamides; Torsades de Pointes; Verapamil

2010
Looking for virtuous promiscuity: electrocardiographic evidence of multichannel drug block.
    Clinical pharmacology and therapeutics, 2014, Volume: 96, Issue:5

    Topics: Acetanilides; Electrocardiography; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Phenethylamines; Piperazines; Potassium Channel Blockers; Quinidine; Ranolazine; Sulfonamides; Verapamil

2014
Quantitative Profiling of the Effects of Vanoxerine on Human Cardiac Ion Channels and its Application to Cardiac Risk.
    Scientific reports, 2015, Nov-30, Volume: 5

    Topics: Action Potentials; Animals; Bepridil; CHO Cells; Computer Simulation; Cricetulus; Ether-A-Go-Go Potassium Channels; Heart; HEK293 Cells; Humans; Inhibitory Concentration 50; Ion Channels; Membrane Potentials; Models, Biological; Myocardium; Myocytes, Cardiac; Patch-Clamp Techniques; Phenethylamines; Piperazines; Sulfonamides; Verapamil

2015
Evaluation of Possible Proarrhythmic Potency: Comparison of the Effect of Dofetilide, Cisapride, Sotalol, Terfenadine, and Verapamil on hERG and Native IKr Currents and on Cardiac Action Potential.
    Toxicological sciences : an official journal of the Society of Toxicology, 2019, 04-01, Volume: 168, Issue:2

    Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Drug Evaluation, Preclinical; ERG1 Potassium Channel; Female; Heart Ventricles; Humans; Ion Channels; Male; Myocytes, Cardiac; Patch-Clamp Techniques; Phenethylamines; Potassium Channel Blockers; Rabbits; Sotalol; Sulfonamides; Terfenadine; Tissue Donors; Verapamil

2019
Assessment of Drug Proarrhythmic Potential in Electrically Paced Human Induced Pluripotent Stem Cell-Derived Ventricular Cardiomyocytes Using Multielectrode Array.
    SLAS discovery : advancing life sciences R & D, 2021, Volume: 26, Issue:3

    Topics: Action Potentials; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium; Cations, Divalent; Cell Differentiation; Humans; Induced Pluripotent Stem Cells; Ion Transport; Microelectrodes; Models, Biological; Myocardial Contraction; Myocytes, Cardiac; Nifedipine; Patch-Clamp Techniques; Phenethylamines; Primary Cell Culture; Quinidine; Sotalol; Sulfonamides; Tetrodotoxin; Verapamil

2021