Page last updated: 2024-08-25

uk 68798 and terfenadine

uk 68798 has been researched along with terfenadine in 28 studies

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (3.57)18.2507
2000's14 (50.00)29.6817
2010's12 (42.86)24.3611
2020's1 (3.57)2.80

Authors

AuthorsStudies
Cavalli, A; De Ponti, F; Poluzzi, E; Recanatini, M1
Chen, XL; Hendrix, J; Kang, J; Korolev, AM; Lysenkova, LN; Miroshnikova, OV; Pearlstein, RA; Preobrazhenskaya, M; Rampe, D; Shchekotikhin, AE; Vaz, RJ1
Keserü, GM1
Du, LP; Li, MY; Tsai, KC; Xia, L; You, QD1
Nagashima, R; Nishikawa, T; Tobita, M1
Jia, L; Sun, H1
Caron, G; Ermondi, G; Visentin, S1
Cooper, J; Cui, Y; Fink, M; Gavaghan, DJ; Heath, BM; McMahon, NC; Mirams, GR; Noble, D; Sher, A1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Fijorek, K; Glinka, A; Mendyk, A; Polak, S; Wiśniowska, B1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Brown, AM; Bruening-Wright, A; Kramer, J; Kuryshev, YA; Myatt, G; Obejero-Paz, CA; Verducci, JS1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Brown, AM; Dennis, A; Rampe, D; Roy, ML1
Tytgat, J; Ulens, C1
Annunziato, L; Cataldi, M; Di Renzo, G; Giorgio, G; Secondo, A; Taglialatela, M; Valore, M1
Finlayson, K; January, CT; Kelly, JS; Sharkey, J; Turnbull, L1
Hashimoto, K; Miyata, K; Nakamura, Y; Sato, S; Satoh, Y; Shimizu-Sasamata, M; Sugiyama, A; Takahara, A1
Dong, DL; Du, ZM; Li, Z; Wang, HZ; Xu, CQ; Xu, DH; Yang, BF1
Cox, BF; Gintant, GA; Limberis, JT; Martin, RL; Su, Z1
Clozel, M; Hess, P; Rey, M; Steiner, B; Wanner, D1
Friemel, A; Zünkler, BJ1
Cox, BF; Diaz, GJ; Gintant, GA; Houseman, K; Limberis, JT; Liu, X; Martin, RL; Su, Z1
Brandenburger, M; Grunow, B; Mehnert, JM1
Clancy, CE; Romero, L; Saiz, J; Trenor, B; Yang, PC1
Árpádffy-Lovas, T; Gazdag, P; Geramipour, A; Jost, N; Kohajda, Z; Orvos, P; Szlovák, J; Tálosi, L; Tóth, D; Varró, A; Virág, L1
Claydon, TW; Genge, CE; Gunawan, M; Hobbs, Y; Hull, CM; Lin, E; Rayani, K; Shafaattalab, S; Tibbits, GF1
Becker, N; Brinkwirth, N; Doi, M; Fertig, N; Friis, S; Furukawa, H; Hasegawa, Y; Obergrussberger, A; Ohtsuki, A; Oka, T; Stoelzle-Feix, S; Takasuna, K1

Other Studies

28 other study(ies) available for uk 68798 and terfenadine

ArticleYear
Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers.
    Journal of medicinal chemistry, 2002, Aug-29, Volume: 45, Issue:18

    Topics: Anti-Arrhythmia Agents; Cation Transport Proteins; Cluster Analysis; Databases, Factual; Ether-A-Go-Go Potassium Channels; Long QT Syndrome; Models, Molecular; Molecular Conformation; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship

2002
Characterization of HERG potassium channel inhibition using CoMSiA 3D QSAR and homology modeling approaches.
    Bioorganic & medicinal chemistry letters, 2003, May-19, Volume: 13, Issue:10

    Topics: Amino Acids, Aromatic; Cation Transport Proteins; DNA-Binding Proteins; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Hydrophobic and Hydrophilic Interactions; Imidazoles; Indoles; Inhibitory Concentration 50; Models, Molecular; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Protein Binding; Protein Conformation; Quantitative Structure-Activity Relationship; Structural Homology, Protein; Structure-Activity Relationship; Trans-Activators; Transcriptional Regulator ERG

2003
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
    Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16

    Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship

2003
The pharmacophore hypotheses of I(Kr) potassium channel blockers: novel class III antiarrhythmic agents.
    Bioorganic & medicinal chemistry letters, 2004, Sep-20, Volume: 14, Issue:18

    Topics: Anti-Arrhythmia Agents; Models, Biological; Models, Molecular; Potassium Channel Blockers; Potassium Channels; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical

2004
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
    Bioorganic & medicinal chemistry letters, 2005, Jun-02, Volume: 15, Issue:11

    Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated

2005
Support vector machines classification of hERG liabilities based on atom types.
    Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11

    Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve

2008
GRIND-based 3D-QSAR and CoMFA to investigate topics dominated by hydrophobic interactions: the case of hERG K+ channel blockers.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:5

    Topics: Ether-A-Go-Go Potassium Channels; Humans; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Potassium Channel Blockers; Quantitative Structure-Activity Relationship

2009
Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk.
    Cardiovascular research, 2011, Jul-01, Volume: 91, Issue:1

    Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Computer Simulation; Dogs; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Guinea Pigs; HEK293 Cells; Humans; Ion Channels; Kinetics; Models, Cardiovascular; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Potassium Channel Blockers; Rabbits; Risk Assessment; Risk Factors; Sodium Channel Blockers; Sodium Channels; Torsades de Pointes; Transfection

2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment.
    Journal of applied toxicology : JAT, 2012, Volume: 32, Issue:10

    Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computational Biology; Computer Simulation; Drugs, Investigational; Ether-A-Go-Go Potassium Channels; Expert Systems; Heart Rate; Humans; Models, Biological; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Potassium Channel Blockers; Quantitative Structure-Activity Relationship; Risk Assessment; Shaker Superfamily of Potassium Channels; Torsades de Pointes; Voltage-Gated Sodium Channel Blockers

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
MICE models: superior to the HERG model in predicting Torsade de Pointes.
    Scientific reports, 2013, Volume: 3

    Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Theoretical; Patch-Clamp Techniques; Predictive Value of Tests; Torsades de Pointes

2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
A mechanism for the proarrhythmic effects of cisapride (Propulsid): high affinity blockade of the human cardiac potassium channel HERG.
    FEBS letters, 1997, Nov-03, Volume: 417, Issue:1

    Topics: Arrhythmias, Cardiac; Cation Transport Proteins; Cell Line; Cisapride; DNA-Binding Proteins; Electrophysiology; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Heart; Humans; Kv1.5 Potassium Channel; Myocardium; Patch-Clamp Techniques; Phenethylamines; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Sulfonamides; Terfenadine; Trans-Activators; Transcriptional Regulator ERG; Transfection; Tumor Cells, Cultured

1997
Redox state dependency of HERGS631C channel pharmacology: relation to C-type inactivation.
    FEBS letters, 2000, May-26, Volume: 474, Issue:1

    Topics: Animals; Astemizole; Cation Transport Proteins; DNA-Binding Proteins; Electric Conductivity; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Female; Gene Expression; Humans; Microelectrodes; Mutation; Oocytes; Oxidation-Reduction; Patch-Clamp Techniques; Phenethylamines; Potassium Channels; Potassium Channels, Voltage-Gated; Sulfonamides; Terfenadine; Trans-Activators; Transcriptional Regulator ERG; Transfection; Xenopus

2000
Pharmacological blockade of ERG K(+) channels and Ca(2+) influx through store-operated channels exerts opposite effects on intracellular Ca(2+) oscillations in pituitary GH(3) cells.
    Molecular pharmacology, 2000, Volume: 58, Issue:5

    Topics: Animals; Anti-Arrhythmia Agents; Astemizole; Biological Transport; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cation Transport Proteins; Cells, Cultured; Cetirizine; Electrophysiology; Ether-A-Go-Go Potassium Channels; Histamine H1 Antagonists; Hydroxyzine; Large-Conductance Calcium-Activated Potassium Channels; Nimodipine; Phenethylamines; Pituitary Gland; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Calcium-Activated; Potassium Channels, Voltage-Gated; Rats; Small-Conductance Calcium-Activated Potassium Channels; Sulfonamides; Terfenadine

2000
[3H]dofetilide binding to HERG transfected membranes: a potential high throughput preclinical screen.
    European journal of pharmacology, 2001, Oct-26, Volume: 430, Issue:1

    Topics: Anti-Arrhythmia Agents; Benzimidazoles; Binding, Competitive; Cation Transport Proteins; Cell Line; Cell Membrane; DNA-Binding Proteins; Drug Evaluation, Preclinical; Electrocardiography; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Haloperidol; Humans; Patch-Clamp Techniques; Phenethylamines; Pimozide; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quaternary Ammonium Compounds; Sulfanilamides; Sulfonamides; Terfenadine; Trans-Activators; Transcriptional Regulator ERG; Transfection; Tritium

2001
Famotidine does not induce long QT syndrome: experimental evidence from in vitro and in vivo test systems.
    European journal of pharmacology, 2003, Apr-11, Volume: 466, Issue:1-2

    Topics: Action Potentials; Animals; Cation Transport Proteins; Cell Line; DNA-Binding Proteins; Dogs; Electrocardiography; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Famotidine; Guinea Pigs; Heart Block; Hemodynamics; Histamine H1 Antagonists; Histamine H2 Antagonists; Humans; In Vitro Techniques; Long QT Syndrome; Papillary Muscles; Patch-Clamp Techniques; Phenethylamines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Sulfonamides; Terfenadine; Torsades de Pointes; Trans-Activators; Transcriptional Regulator ERG

2003
Inactivation gating determines drug potency: a common mechanism for drug blockade of HERG channels.
    Acta pharmacologica Sinica, 2004, Volume: 25, Issue:5

    Topics: Animals; Anti-Allergic Agents; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Female; Ganglionic Stimulants; Ion Channel Gating; Mutation; Nicotine; Oocytes; Patch-Clamp Techniques; Phenethylamines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quinidine; Sulfonamides; Terfenadine; Xenopus laevis

2004
Altering extracellular potassium concentration does not modulate drug block of human ether-a-go-go-related gene (hERG) channels.
    Clinical and experimental pharmacology & physiology, 2006, Volume: 33, Issue:11

    Topics: Cell Line; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Kidney; Mesoridazine; Phenethylamines; Potassium; Potassium Channel Blockers; Quinidine; Sulfonamides; Terfenadine

2006
Measurements of blood pressure and electrocardiogram in conscious freely moving guineapigs: a model for screening QT interval prolongation effects.
    Laboratory animals, 2007, Volume: 41, Issue:4

    Topics: Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Blood Pressure; Blood Pressure Determination; Electrocardiography; Enalapril; Guinea Pigs; Heart Rate; Histamine H1 Antagonists, Non-Sedating; Male; Models, Animal; Phenethylamines; Sotalol; Sulfonamides; Telemetry; Terfenadine

2007
Interactions at human ether-à-go-go-related gene channels.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 114, Issue:2

    Topics: Binding Sites; Cell Line; Chlorobutanol; Drug Combinations; Drug Synergism; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Fluvoxamine; Histamine H1 Antagonists, Non-Sedating; Humans; Kidney; Patch-Clamp Techniques; Phenethylamines; Scorpion Venoms; Sulfonamides; Terfenadine

2010
Characterization of A-935142, a hERG enhancer, in the presence and absence of standard hERG blockers.
    Life sciences, 2012, Apr-20, Volume: 90, Issue:15-16

    Topics: Acetates; Analysis of Variance; Ether-A-Go-Go Potassium Channels; HEK293 Cells; Humans; Patch-Clamp Techniques; Phenethylamines; Pyrazoles; Sotalol; Sulfonamides; Terfenadine; Tritium

2012
Electrophysiological characterization of spontaneously contracting cell aggregates obtained from rainbow trout larvae with multielectrode arrays.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2013, Volume: 32, Issue:5

    Topics: Amino Acid Sequence; Animals; Cardiac Electrophysiology; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Fish Proteins; Heart; Humans; Larva; Molecular Sequence Data; Myocardium; Oncorhynchus mykiss; Phenethylamines; Potassium Channel Blockers; Sequence Homology, Amino Acid; Sulfonamides; Terfenadine

2013
In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome.
    Journal of molecular and cellular cardiology, 2014, Volume: 72

    Topics: Action Potentials; Anti-Arrhythmia Agents; Astemizole; Cisapride; Computer Simulation; Gene Expression; Genetic Predisposition to Disease; Heart Ventricles; Humans; Ion Channel Gating; Kinetics; Long QT Syndrome; Models, Statistical; Mutation; Phenethylamines; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Protein Conformation; Severity of Illness Index; Sotalol; Sulfonamides; Terfenadine

2014
Evaluation of Possible Proarrhythmic Potency: Comparison of the Effect of Dofetilide, Cisapride, Sotalol, Terfenadine, and Verapamil on hERG and Native IKr Currents and on Cardiac Action Potential.
    Toxicological sciences : an official journal of the Society of Toxicology, 2019, 04-01, Volume: 168, Issue:2

    Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Drug Evaluation, Preclinical; ERG1 Potassium Channel; Female; Heart Ventricles; Humans; Ion Channels; Male; Myocytes, Cardiac; Patch-Clamp Techniques; Phenethylamines; Potassium Channel Blockers; Rabbits; Sotalol; Sulfonamides; Terfenadine; Tissue Donors; Verapamil

2019
Investigating the utility of adult zebrafish ex vivo whole hearts to pharmacologically screen hERG channel activator compounds.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2019, 12-01, Volume: 317, Issue:6

    Topics: Animals; Chlorobenzenes; Cresols; Ether-A-Go-Go Potassium Channels; Gene Expression Regulation; Heart; Histamine H1 Antagonists, Non-Sedating; Oocytes; ortho-Aminobenzoates; Phenethylamines; Phenylurea Compounds; Piperidines; Potassium Channel Blockers; Quinolines; Sulfonamides; Terfenadine; Xenopus laevis; Zebrafish; Zebrafish Proteins

2019
Reliable identification of cardiac liability in drug discovery using automated patch clamp: Benchmarking best practices and calibration standards for improved proarrhythmic assessment.
    Journal of pharmacological and toxicological methods, 2020, Volume: 105

    Topics: Animals; Arrhythmias, Cardiac; Astemizole; Benchmarking; Calibration; Cardiovascular Agents; Cell Line; CHO Cells; Cricetulus; Drug Discovery; Drug Evaluation, Preclinical; ERG1 Potassium Channel; Heart; HEK293 Cells; Humans; Patch-Clamp Techniques; Phenethylamines; Polypropylenes; Polytetrafluoroethylene; Reference Standards; Reproducibility of Results; Sulfonamides; Terfenadine

2020