uk 68798 has been researched along with piperidines in 35 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 21 (60.00) | 18.2507 |
| 2000's | 10 (28.57) | 29.6817 |
| 2010's | 3 (8.57) | 24.3611 |
| 2020's | 1 (2.86) | 2.80 |
| Authors | Studies |
|---|---|
| Colatsky, TJ; Parsons, RW; Spinelli, W | 1 |
| Sanguinetti, MC | 1 |
| Baskin, EP; Brookes, LM; Claremon, DA; Lynch, JJ; Selnick, HG; Serik, CM; Wallace, AA | 1 |
| Brookes, LM; Claremon, DA; Lynch, JJ; Selnick, HG; Stupienski, RF; Wallace, AA | 1 |
| Brunden, MN; Buchanan, LV; Gibson, JK; Kabell, G | 1 |
| Krafte, DS; Volberg, WA | 1 |
| Baskin, EP; Lynch, JJ | 2 |
| De Clerck, F; Lu, HR; Remeysen, P | 1 |
| Baskin, EP; Guinosso, PJ; Hamill, T; Lynch, JJ; Nutt, EM; Salata, JJ; Woods, CM | 1 |
| Colatsky, TJ; Moubarak, IF; Parsons, RW; Spinelli, W | 1 |
| Abrahamsson, C; Carlsson, L; Duker, G; Lundberg, C | 1 |
| Lee, EW; Lee, KS; Tsai, TD | 1 |
| Mitamura, H; Ogawa, S; Okada, Y; Sadanaga, T | 1 |
| Martin, CL; Mcmahon, EG; Palomo, MA | 1 |
| Edwards, G; Högestätt, ED; Larsson, B; Weston, AH; Zygmunt, PM | 1 |
| Brown, AM; Dennis, A; Rampe, D; Roy, ML | 1 |
| Chiba, S; Furukawa, Y; Hoyano, Y; Imamura, H; Kasama, M; Yonezawa, T | 1 |
| Bril, A; Faivre, JF; Rouanet, S | 1 |
| Beatch, GN; Dickenson, DR; Williams, BA | 1 |
| Bianchi, L; Castaldo, P; Emmi, A; Janigro, D; Nerbonne, J; Robertson, GA; Schwartzkroin, PA; Taglialatela, M; Wenzel, HJ | 1 |
| January, CT; Xie, JT; Yuan, CS; Zhou, Z | 1 |
| Kondo, M; Mashima, S; Tsutsumi, T | 1 |
| Adamantidis, MM; Bastide, M; Dumotier, BM | 1 |
| Dai, DZ; Kong, RZ; Li, HT; Wang, YQ | 1 |
| Endoh, M; Ishii, K; Nagai, M; Takahashi, M | 1 |
| Benavides-Haro, DE; Navarro-Polanco, RA; Sánchez-Chapula, JA | 1 |
| de Groot, MJ; Helliwell, R; Leishman, D; Mitcheson, J; Perry, M; Sanguinetti, MC; Tristani-Firouzi, M | 1 |
| Augelli-Szafran, CE; Bradley, JA; Chen, X; Cordes, JS; Koci, BJ; Sun, Z; Volberg, WA; Zhou, J | 1 |
| Kamiya, K; Mitcheson, JS; Niwa, R; Sanguinetti, MC | 1 |
| Contreras-Jurado, C; Furini, S; García-Ferreiro, R; Gómez-Varela, D; Pardo, LA; Stühmer, W | 1 |
| Beekman, JD; de Boer, TP; Duker, G; Houtman, MJ; Jonsson, MK; Nalos, L; Peschar, M; Rook, MB; Sartipy, P; Thomsen, MB; van der Heyden, MA; van der Nagel, R; van Veen, TA; Varkevisser, R; Vos, MA | 1 |
| Gardner, A; Sanguinetti, MC; Wu, W | 1 |
| Claydon, TW; Genge, CE; Gunawan, M; Hobbs, Y; Hull, CM; Lin, E; Rayani, K; Shafaattalab, S; Tibbits, GF | 1 |
| Charpentier, F; De Waard, M; De Waard, S; Forest, V; Gaborit, N; Lemarchand, P; Loussouarn, G; Mangoni, ME; Montnach, J; Nicolas, S; Ribeiro, B; Ronjat, M | 1 |
1 review(s) available for uk 68798 and piperidines
| Article | Year |
|---|---|
Modulation of potassium channels by antiarrhythmic and antihypertensive drugs.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Muscle, Smooth; Phenethylamines; Piperidines; Potassium Channels; Pyridines; Sulfonamides | 1992 |
1 trial(s) available for uk 68798 and piperidines
| Article | Year |
|---|---|
Assessment of reverse use-dependent blocking actions of class III antiarrhythmic drugs by 24-hour Holter electrocardiography.
Topics: Adult; Aged; Analysis of Variance; Anti-Arrhythmia Agents; Electrocardiography, Ambulatory; Female; Humans; Long QT Syndrome; Male; Middle Aged; Phenethylamines; Piperidines; Pyridines; Pyrimidinones; Regression Analysis; Sotalol; Statistics, Nonparametric; Sulfonamides | 1996 |
33 other study(ies) available for uk 68798 and piperidines
| Article | Year |
|---|---|
Effects of WAY-123,398, a new class III antiarrhythmic agent, on cardiac refractoriness and ventricular fibrillation threshold in anesthetized dogs: a comparison with UK-68798, E-4031, and dl-sotalol.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Atrioventricular Node; Benzimidazoles; Dogs; Electrocardiography; Electrophysiology; Female; Heart; Heart Conduction System; Hemodynamics; In Vitro Techniques; Male; Phenethylamines; Piperidines; Purkinje Fibers; Pyridines; Refractory Period, Electrophysiological; Sotalol; Sulfanilamides; Sulfonamides; Ventricular Fibrillation | 1992 |
Effects of new and potent methanesulfonanilide class III antiarrhythmic agents on myocardial refractoriness and contractility in isolated cardiac muscle.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Ferrets; Heart; Hypoxia; In Vitro Techniques; Male; Myocardial Contraction; Phenethylamines; Piperidines; Pyrazines; Pyridines; Refractory Period, Electrophysiological; Sotalol; Sulfonamides; Temperature | 1991 |
Cardiac electrophysiologic and inotropic actions of new and potent methanesulfonanilide class III antiarrhythmic agents in anesthetized dogs.
Topics: Animals; Anti-Arrhythmia Agents; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Electrophysiology; Female; Heart; Hemodynamics; Male; Myocardial Contraction; Phenethylamines; Piperidines; Pyrazines; Pyridines; Refractory Period, Electrophysiological; Sotalol; Sulfonamides | 1991 |
Comparative assessment of ibutilide, D-sotalol, clofilium, E-4031, and UK-68,798 in a rabbit model of proarrhythmia.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Electrocardiography; Heart Conduction System; Heart Rate; Male; Methoxamine; Phenethylamines; Piperidines; Pyridines; Quaternary Ammonium Compounds; Rabbits; Software; Sotalol; Sulfonamides; Torsades de Pointes | 1993 |
Voltage dependence of cardiac delayed rectifier block by methanesulfonamide class III antiarrhythmic agents.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Electrophysiology; Guinea Pigs; Heart Ventricles; In Vitro Techniques; Phenethylamines; Piperidines; Procainamide; Pyridines; Sotalol; Stereoisomerism; Sulfonamides; Ventricular Function | 1994 |
Comparative effects of increased extracellular potassium and pacing frequency on the class III activities of methanesulfonanilide IKr blockers dofetilide, D-sotalol, E-4031, and MK-499.
Topics: Animals; Anti-Arrhythmia Agents; Benzopyrans; Electric Stimulation; Ferrets; Male; Phenethylamines; Piperidines; Potassium; Potassium Channel Blockers; Pyridines; Refractory Period, Electrophysiological; Sotalol; Sulfonamides | 1994 |
Antifibrillary action of class I-IV antiarrhythmic agents in the model of ventricular fibrillation threshold of anesthetized guinea pigs.
Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Atenolol; Benzopyrans; Chromans; Disease Models, Animal; Electric Stimulation; Electrocardiography; Encainide; Ethanolamines; Guinea Pigs; Heart; Heart Conduction System; Injections, Intravenous; Male; Metoprolol; Nebivolol; Phenethylamines; Piperidines; Sotalol; Sulfonamides; Ventricular Fibrillation; Verapamil | 1995 |
Comparison of binding to rapidly activating delayed rectifier K+ channel, IKr, and effects on myocardial refractoriness for class III antiarrhythmic agents.
Topics: Animals; Anti-Arrhythmia Agents; Binding, Competitive; Chromans; Electrophysiology; Guinea Pigs; Heart Ventricles; Papillary Muscles; Phenethylamines; Piperidines; Potassium Channel Blockers; Potassium Channels; Procainamide; Pyridines; Sotalol; Structure-Activity Relationship; Sulfonamides; Tritium | 1995 |
Cellular electrophysiology of WAY-123,398, a new class III antiarrhythmic agent: specificity of IK block and lack of reverse use dependence in cat ventricular myocytes.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Benzimidazoles; Cats; Cells, Cultured; Culture Techniques; Dogs; Dose-Response Relationship, Drug; Myocardium; Phenethylamines; Piperidines; Potassium Channels; Purkinje Fibers; Pyridines; Sotalol; Sulfanilamides; Sulfonamides | 1993 |
Electrophysiological and inotropic effects of H 234/09 (almokalant) in vitro: a comparison with two other novel IK blocking drugs, UK-68,798 (dofetilide) and E-4031.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Cats; Dose-Response Relationship, Drug; Heart; In Vitro Techniques; Male; Myocardial Contraction; Papillary Muscles; Phenethylamines; Piperidines; Propanolamines; Purkinje Fibers; Pyridines; Rabbits; Stimulation, Chemical; Sulfonamides | 1993 |
Membrane activity of class III antiarrhythmic compounds; a comparison between ibutilide, d-sotalol, E-4031, sematilide and dofetilide.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Guinea Pigs; Heart; In Vitro Techniques; Membrane Potentials; Phenethylamines; Piperidines; Potassium Channels; Procainamide; Pyridines; Sotalol; Sulfonamides | 1993 |
Comparison of bidisomide, flecainide and dofetilide on action potential duration in isolated canine atria: effect of isoproterenol.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Dogs; Dose-Response Relationship, Drug; Flecainide; Guinea Pigs; Heart Atria; Isoproterenol; Male; Phenethylamines; Piperidines; Sulfonamides | 1996 |
Involvement of voltage-dependent potassium channels in the EDHF-mediated relaxation of rat hepatic artery.
Topics: 4-Aminopyridine; Acetylcholine; Animals; Anti-Arrhythmia Agents; Apamin; Binding, Competitive; Biological Factors; Cerebral Cortex; Charybdotoxin; Chromans; Cyclooxygenase Inhibitors; Drug Interactions; Female; Hepatic Artery; Indoles; Indomethacin; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitroarginine; Patch-Clamp Techniques; Phenethylamines; Piperidines; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley; Sulfonamides | 1997 |
A mechanism for the proarrhythmic effects of cisapride (Propulsid): high affinity blockade of the human cardiac potassium channel HERG.
Topics: Arrhythmias, Cardiac; Cation Transport Proteins; Cell Line; Cisapride; DNA-Binding Proteins; Electrophysiology; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Heart; Humans; Kv1.5 Potassium Channel; Myocardium; Patch-Clamp Techniques; Phenethylamines; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Sulfonamides; Terfenadine; Trans-Activators; Transcriptional Regulator ERG; Transfection; Tumor Cells, Cultured | 1997 |
Inhibition of delayed rectifier K+ current by dofetilide and E-4031 differentially affects electrical cardiac responses to vagus stimulation in anesthetized dogs.
Topics: Animals; Anti-Arrhythmia Agents; Bradycardia; Disease Models, Animal; Disopyramide; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Electrophysiology; Female; Heart Conduction System; Male; Phenethylamines; Piperidines; Potassium Channel Blockers; Pyridines; Sulfonamides; Vagus Nerve | 1998 |
Differential atrial versus ventricular activities of class III potassium channel blockers.
Topics: Animals; Anti-Arrhythmia Agents; Atrial Function; Ferrets; Heart; Hydantoins; Imidazoles; Imidazolidines; Male; Papillary Muscles; Phenethylamines; Piperazines; Piperidines; Potassium Channel Blockers; Potassium Channels; Pyridines; Sulfonamides; Temperature; Ventricular Function | 1998 |
Comparative effects of glibenclamide, tedisamil, dofetilide, E-4031, and BRL-32872 on protein kinase A-activated chloride current in guinea pig ventricular myocytes.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; Acetylcholine; Animals; Anti-Arrhythmia Agents; Benzamides; Bridged Bicyclo Compounds, Heterocyclic; Cardiotonic Agents; Chlorides; Cyclic AMP-Dependent Protein Kinases; Cyclopropanes; Glyburide; Guinea Pigs; Heart Ventricles; Hypoglycemic Agents; Ion Transport; Isoproterenol; Male; Myocardium; Patch-Clamp Techniques; Phenethylamines; Piperidines; Potassium Channels; Propranolol; Pyridines; Sulfonamides | 1998 |
Kinetics of rate-dependent shortening of action potential duration in guinea-pig ventricle; effects of IK1 and IKr blockade.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Chromans; Dose-Response Relationship, Drug; Guinea Pigs; Heart Ventricles; Kinetics; Patch-Clamp Techniques; Phenethylamines; Piperidines; Potassium Channel Blockers; Potassium Channels; Sensitivity and Specificity; Sulfonamides; Time Factors; Ventricular Function | 1999 |
Do glia have heart? Expression and functional role for ether-a-go-go currents in hippocampal astrocytes.
Topics: Animals; Anti-Arrhythmia Agents; Astrocytes; Cation Transport Proteins; Cell Communication; Cesium; Dose-Response Relationship, Drug; Electrophysiology; Epilepsy; Ether-A-Go-Go Potassium Channels; Gene Expression; Heart; Hippocampus; In Vitro Techniques; Long QT Syndrome; Male; Membrane Potentials; Microscopy, Electron; Neurons; Oligonucleotide Probes; Phenethylamines; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Rats; Rats, Wistar; RNA, Messenger; Spinal Cord; Sulfonamides | 2000 |
Enhancement of delayed afterdepolarizations and triggered activity by class III antiarrhythmic drugs: multiple effects of E-4031 and dofetilide.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Phenethylamines; Piperidines; Purkinje Fibers; Pyridines; Sheep; Sulfonamides; Time Factors | 2000 |
Potassium channel openers antagonize the effects of class III antiarrhythmic agents in canine Purkinje fiber action potentials. Implications for prevention of proarrhythmia induced by class III agents.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dogs; Phenethylamines; Piperidines; Potassium Channel Blockers; Potassium Channels; Purkinje Fibers; Pyridines; Sulfonamides | 1999 |
"Use-dependent" effects of cisapride on postrest action potentials in rabbit ventricular myocardium.
Topics: 4-Aminopyridine; Action Potentials; Animals; Anti-Arrhythmia Agents; Chromans; Cisapride; Dose-Response Relationship, Drug; Electric Stimulation; Heart Ventricles; In Vitro Techniques; Male; Phenethylamines; Piperidines; Rabbits; Sulfonamides; Time Factors; Ventricular Function | 2001 |
Frequency dependent prolongation of effective refractory period by a complex class III antiarrhythmic agent CPU-86017.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Benzeneacetamides; Berberine; Calcium Channel Blockers; Female; Guinea Pigs; Heart Atria; In Vitro Techniques; Male; Papillary Muscles; Phenethylamines; Piperidines; Potassium Channel Blockers; Refractory Period, Electrophysiological; Sulfonamides; Verapamil | 2001 |
Dissociation of E-4031 from the HERG channel caused by mutations of an amino acid results in greater block at high stimulation frequency.
Topics: Animals; Anti-Arrhythmia Agents; Cation Transport Proteins; Dose-Response Relationship, Drug; Ether-A-Go-Go Potassium Channels; Isoleucine; Long QT Syndrome; Mutagenesis, Site-Directed; Oocytes; Patch-Clamp Techniques; Phenethylamines; Piperidines; Point Mutation; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Sulfonamides; Xenopus | 2003 |
The cholinomimetic agent bethanechol activates IK(ACh) in feline atrial myocytes.
Topics: Animals; Barium; Bee Venoms; Benzodiazepines; Bethanechol; Cats; Cholinergic Agents; Diamines; Heart Atria; In Vitro Techniques; Membrane Potentials; Muscarinic Agonists; Muscarinic Antagonists; Muscle Cells; Phenethylamines; Piperidines; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptor, Muscarinic M4; Sulfonamides; Tropicamide | 2003 |
Structural determinants of HERG channel block by clofilium and ibutilide.
Topics: Amino Acid Substitution; Animals; Anti-Arrhythmia Agents; Aspartic Acid; Benzopyrans; Binding Sites; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Oocytes; Phenethylamines; Phenylalanine; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Quaternary Ammonium Compounds; Serine; Sulfonamides; Tyrosine; Xenopus laevis | 2004 |
Novel potent human ether-a-go-go-related gene (hERG) potassium channel enhancers and their in vitro antiarrhythmic activity.
Topics: Animals; Anti-Arrhythmia Agents; Cells, Cultured; Chlorobenzenes; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Guinea Pigs; Heart; Humans; Male; ortho-Aminobenzoates; Phenethylamines; Piperidines; Potassium Channels, Voltage-Gated; Quinolines; Sulfonamides | 2005 |
Molecular determinants of HERG channel block.
Topics: DNA Primers; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Kinetics; Long QT Syndrome; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Phenethylamines; Piperidines; Potassium Channel Blockers; Pyridines; Recombinant Proteins; Sulfonamides | 2006 |
Different relevance of inactivation and F468 residue in the mechanisms of hEag1 channel blockage by astemizole, imipramine and dofetilide.
Topics: Astemizole; Benzopyrans; Ether-A-Go-Go Potassium Channels; Humans; Imipramine; Ion Channel Gating; Models, Molecular; Phenethylamines; Piperidines; Point Mutation; Potassium Channel Blockers; Structure-Activity Relationship; Sulfonamides | 2006 |
Comparison of the IKr blockers moxifloxacin, dofetilide and E-4031 in five screening models of pro-arrhythmia reveals lack of specificity of isolated cardiomyocytes.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Aza Compounds; Cell Line; Disease Models, Animal; Dogs; Embryonic Stem Cells; Female; Fluoroquinolones; Heart; Heart Block; Humans; Methoxamine; Moxifloxacin; Myocytes, Cardiac; Phenethylamines; Piperidines; Potassium Channel Blockers; Pyridines; Quinolines; Rabbits; Sulfonamides; Torsades de Pointes; Ventricular Remodeling | 2012 |
The Link between Inactivation and High-Affinity Block of hERG1 Channels.
Topics: Animals; Benzopyrans; Cisapride; Ether-A-Go-Go Potassium Channels; Female; Humans; Ion Channel Gating; Oocytes; Patch-Clamp Techniques; Phenethylamines; Piperidines; Point Mutation; Potassium Channel Blockers; Protein Multimerization; Protein Subunits; Sulfonamides; Xenopus laevis | 2015 |
Investigating the utility of adult zebrafish ex vivo whole hearts to pharmacologically screen hERG channel activator compounds.
Topics: Animals; Chlorobenzenes; Cresols; Ether-A-Go-Go Potassium Channels; Gene Expression Regulation; Heart; Histamine H1 Antagonists, Non-Sedating; Oocytes; ortho-Aminobenzoates; Phenethylamines; Phenylurea Compounds; Piperidines; Potassium Channel Blockers; Quinolines; Sulfonamides; Terfenadine; Xenopus laevis; Zebrafish; Zebrafish Proteins | 2019 |
Functional Impact of BeKm-1, a High-Affinity hERG Blocker, on Cardiomyocytes Derived from Human-Induced Pluripotent Stem Cells.
Topics: Action Potentials; Anti-Arrhythmia Agents; Calcium; Calcium Channels; Cell Differentiation; ERG1 Potassium Channel; HEK293 Cells; Humans; Induced Pluripotent Stem Cells; Ion Transport; Long QT Syndrome; Models, Biological; Myocytes, Cardiac; Patch-Clamp Techniques; Phenethylamines; Piperidines; Potassium; Potassium Channel Blockers; Pyridines; Scorpion Venoms; Sulfonamides | 2020 |