Page last updated: 2024-08-25

uk 68798 and mexiletine

uk 68798 has been researched along with mexiletine in 14 studies

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (28.57)18.2507
2000's3 (21.43)29.6817
2010's6 (42.86)24.3611
2020's1 (7.14)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Lombardo, F; Obach, RS; Waters, NJ1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Cooper, J; Cui, Y; Fink, M; Gavaghan, DJ; Heath, BM; McMahon, NC; Mirams, GR; Noble, D; Sher, A1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Raberger, G; Schütz, W; Todt, H; Zojer, N1
Brown, AM; Cantù, F; Napolitano, C; Priori, SG; Schwartz, PJ1
Cantù, F; Priori, SG; Schwartz, PJ1
Cantù, F; Napolitano, C; Paganini, V; Priori, SG; Schwartz, PJ1
Blinova, K; Chan, D; Crumb, WJ; Erato, C; Florian, J; Guo, P; Hong, M; Johannesen, L; Lin, J; Mason, JW; Mutlib, A; Sanabria, C; Stockbridge, N; Stohlman, J; Strauss, DG; Ugander, M; Vicente, J; Waite-Labott, K; Wang, J1
Hosseini, M; Johannesen, L; Mason, JW; Pueyo, E; Sager, PT; Strauss, DG; Vicente, J1
Bergau, D; Bystricky, W; Carter, D; Gintant, G; Kamradt, K; Maier, C; Welsh, P1
Ackerman, MJ; Das, S; Hamrick, SK; Kim, M; Pradhananga, S; Sager, PT; Srinivasan, D; Tester, DJ1

Reviews

2 review(s) available for uk 68798 and mexiletine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Molecular biology of the long QT syndrome: impact on management.
    Pacing and clinical electrophysiology : PACE, 1997, Volume: 20, Issue:8 Pt 2

    Topics: Action Potentials; Adrenergic Antagonists; Animals; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Cardiotonic Agents; Chromosomes, Human, Pair 11; Chromosomes, Human, Pair 3; Chromosomes, Human, Pair 7; Disease Models, Animal; Electrocardiography; Genetic Therapy; Guinea Pigs; Heart Rate; Humans; Intercellular Signaling Peptides and Proteins; Long QT Syndrome; Mexiletine; Molecular Biology; Myocardium; Peptides; Phenethylamines; Potassium; Potassium Channel Blockers; Potassium Channels; Receptors, Adrenergic; Risk Factors; Sodium Channel Blockers; Sodium Channels; Sulfonamides; Syncope; Tachycardia, Ventricular

1997

Trials

3 trial(s) available for uk 68798 and mexiletine

ArticleYear
Late sodium current block for drug-induced long QT syndrome: Results from a prospective clinical trial.
    Clinical pharmacology and therapeutics, 2016, Volume: 99, Issue:2

    Topics: Adult; Anti-Arrhythmia Agents; Calcium Channel Blockers; Cross-Over Studies; Diltiazem; Drug Therapy, Combination; Electrocardiography; Ether-A-Go-Go Potassium Channels; Female; Fluoroquinolones; Heart Rate; Humans; Lidocaine; Long QT Syndrome; Male; Mexiletine; Moxifloxacin; Phenethylamines; Prospective Studies; Sodium Channel Blockers; Sulfonamides; Young Adult

2016
Electrocardiographic Biomarkers for Detection of Drug-Induced Late Sodium Current Block.
    PloS one, 2016, Volume: 11, Issue:12

    Topics: Adult; Biomarkers; Calcium Channel Blockers; Cross-Over Studies; Electrocardiography; Ether-A-Go-Go Potassium Channels; Female; Heart; Heart Rate; Humans; Lidocaine; Long QT Syndrome; Male; Mexiletine; Phenethylamines; Potassium Channel Blockers; Sodium; Sodium Channel Blockers; Sulfonamides; Torsades de Pointes; Verapamil

2016
T vector velocity: A new ECG biomarker for identifying drug effects on cardiac ventricular repolarization.
    PloS one, 2019, Volume: 14, Issue:7

    Topics: Action Potentials; Adult; Databases, Factual; Double-Blind Method; Electrocardiography; Female; Heart; Humans; Lidocaine; Male; Mexiletine; Phenethylamines; Potassium Channel Blockers; Ranolazine; Sodium Channel Blockers; Sulfonamides; Verapamil; Young Adult

2019

Other Studies

9 other study(ies) available for uk 68798 and mexiletine

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk.
    Cardiovascular research, 2011, Jul-01, Volume: 91, Issue:1

    Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Computer Simulation; Dogs; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Guinea Pigs; HEK293 Cells; Humans; Ion Channels; Kinetics; Models, Cardiovascular; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Potassium Channel Blockers; Rabbits; Risk Assessment; Risk Factors; Sodium Channel Blockers; Sodium Channels; Torsades de Pointes; Transfection

2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Prolongation of the QT interval by dofetilide modulates rate-dependent effects of mexiletine on intraventricular conduction.
    European journal of pharmacology, 1994, Nov-14, Volume: 265, Issue:1-2

    Topics: Action Potentials; Animal Welfare; Animals; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Drug Synergism; Female; Guinea Pigs; Heart Conduction System; Injections, Intravenous; Male; Mathematics; Mexiletine; Phenethylamines; Sodium Channel Blockers; Sulfonamides

1994
Differential response to Na+ channel blockade, beta-adrenergic stimulation, and rapid pacing in a cellular model mimicking the SCN5A and HERG defects present in the long-QT syndrome.
    Circulation research, 1996, Volume: 78, Issue:6

    Topics: Action Potentials; Animals; Cardiac Pacing, Artificial; Cation Transport Proteins; Ether-A-Go-Go Potassium Channels; Guinea Pigs; Intercellular Signaling Peptides and Proteins; Isoproterenol; Long QT Syndrome; Mexiletine; Mutation; Peptides; Phenethylamines; Potassium Channels; Potassium Channels, Voltage-Gated; Receptors, Adrenergic, beta; Sodium Channel Blockers; Sodium Channels; Sulfonamides

1996
The long QT syndrome: new diagnostic and therapeutic approach in the era of molecular biology.
    Schweizerische medizinische Wochenschrift, 1996, Oct-12, Volume: 126, Issue:41

    Topics: Animals; Anti-Arrhythmia Agents; Cardiotonic Agents; Cation Transport Proteins; DNA-Binding Proteins; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Guinea Pigs; Heart Ventricles; Humans; In Vitro Techniques; Intercellular Signaling Peptides and Proteins; Long QT Syndrome; Mexiletine; Peptides; Phenethylamines; Point Mutation; Potassium Channels; Potassium Channels, Voltage-Gated; Sea Anemones; Sodium Channels; Sulfonamides; Trans-Activators; Transcriptional Regulator ERG

1996
SGK1 inhibition attenuates the action potential duration in reengineered heart cell models of drug-induced QT prolongation.
    Heart rhythm, 2023, Volume: 20, Issue:4

    Topics: Action Potentials; Humans; Long QT Syndrome; Mexiletine; Myocytes, Cardiac; Sulfonamides

2023