Page last updated: 2024-08-25

uk 68798 and glyburide

uk 68798 has been researched along with glyburide in 17 studies

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (35.29)18.2507
2000's6 (35.29)29.6817
2010's5 (29.41)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Cavalli, A; De Ponti, F; Poluzzi, E; Recanatini, M1
Lombardo, F; Obach, RS; Waters, NJ1
Caron, G; Ermondi, G; Visentin, S1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Lathrop, DA; Refsum, H; Tande, PM; Yang, T1
Chi, L; Friedrichs, GS; Green, AL; Lucchesi, BR1
Henderson, C; Kane, K; Tweedie, D1
Foster, RW; Isaac, L; McArdle, S; Miller, NM; Small, RC1
Armstrong, JM; Barras, M; Hicks, PE; Lawson, K1
Bril, A; Faivre, JF; Rouanet, S1
Chen, YH; Jiang, B; Li, J; Li, P; Liang, D; Liang, L; Liu, Y; Qi, J; Wen, W; Xiao, J; Zhang, Y; Zhao, C1

Reviews

1 review(s) available for uk 68798 and glyburide

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Other Studies

16 other study(ies) available for uk 68798 and glyburide

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers.
    Journal of medicinal chemistry, 2002, Aug-29, Volume: 45, Issue:18

    Topics: Anti-Arrhythmia Agents; Cation Transport Proteins; Cluster Analysis; Databases, Factual; Ether-A-Go-Go Potassium Channels; Long QT Syndrome; Models, Molecular; Molecular Conformation; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship

2002
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
GRIND-based 3D-QSAR and CoMFA to investigate topics dominated by hydrophobic interactions: the case of hERG K+ channel blockers.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:5

    Topics: Ether-A-Go-Go Potassium Channels; Humans; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Potassium Channel Blockers; Quantitative Structure-Activity Relationship

2009
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Class III antiarrhythmic action by potassium channel blockade: dofetilide attenuates hypoxia induced electromechanical changes.
    Cardiovascular research, 1992, Volume: 26, Issue:11

    Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Glyburide; Guinea Pigs; Muscles; Niacinamide; Nicorandil; Oxygen; Papillary Muscles; Phenethylamines; Potassium Channels; Sulfonamides; Vasodilator Agents

1992
Antifibrillatory effects of clofilium in the rabbit isolated heart.
    British journal of pharmacology, 1994, Volume: 113, Issue:1

    Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Decanoic Acids; Disease Models, Animal; Glyburide; Heart; Hydroxy Acids; In Vitro Techniques; Myocardium; Oxygen Consumption; Patch-Clamp Techniques; Phenethylamines; Potassium Channels; Quaternary Ammonium Compounds; Rabbits; Refractory Period, Electrophysiological; Sulfonamides; Ventricular Fibrillation; Ventricular Pressure

1994
Glibenclamide, but not class III drugs, prevents ischaemic shortening of the refractory period in guinea-pig hearts.
    European journal of pharmacology, 1993, Aug-24, Volume: 240, Issue:2-3

    Topics: Analysis of Variance; Animals; Anti-Arrhythmia Agents; Coronary Circulation; Electrocardiography; Glyburide; Guinea Pigs; Heart; Male; Myocardial Ischemia; Phenethylamines; Phentolamine; Pyrazines; Pyridines; Refractory Period, Electrophysiological; Sulfonamides; Temperature

1993
Effects of some K(+)-channel inhibitors on the electrical behaviour of guinea-pig isolated trachealis and on its responses to spasmogenic drugs.
    British journal of pharmacology, 1996, Volume: 117, Issue:8

    Topics: 4-Aminopyridine; Action Potentials; Animals; Anti-Arrhythmia Agents; Atropine; Carbachol; Charybdotoxin; Electrophysiology; Female; Glyburide; Guinea Pigs; Histamine; Hypoglycemic Agents; Male; Muscle, Smooth; Parasympatholytics; Peptides; Phenethylamines; Potassium Channel Blockers; Scorpion Venoms; Sulfonamides; Trachea

1996
Effects of K+ channel inhibitors and antagonists on NS-004 evoked relaxations in guinea-pig isolated trachea.
    Fundamental & clinical pharmacology, 1997, Volume: 11, Issue:1

    Topics: Animals; Anti-Arrhythmia Agents; Apamin; Benzimidazoles; Charybdotoxin; Chlorophenols; Dose-Response Relationship, Drug; Glyburide; Guinea Pigs; Hypoglycemic Agents; Linear Models; Male; Muscle Relaxation; Muscle, Smooth; Peptides; Phenethylamines; Potassium Channel Blockers; Sulfonamides; Trachea

1997
Comparative effects of glibenclamide, tedisamil, dofetilide, E-4031, and BRL-32872 on protein kinase A-activated chloride current in guinea pig ventricular myocytes.
    Journal of cardiovascular pharmacology, 1998, Volume: 31, Issue:4

    Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; Acetylcholine; Animals; Anti-Arrhythmia Agents; Benzamides; Bridged Bicyclo Compounds, Heterocyclic; Cardiotonic Agents; Chlorides; Cyclic AMP-Dependent Protein Kinases; Cyclopropanes; Glyburide; Guinea Pigs; Heart Ventricles; Hypoglycemic Agents; Ion Transport; Isoproterenol; Male; Myocardium; Patch-Clamp Techniques; Phenethylamines; Piperidines; Potassium Channels; Propranolol; Pyridines; Sulfonamides

1998
Effects of potassium channel blockers on changes in refractoriness of atrial cardiomyocytes induced by stretch.
    Experimental biology and medicine (Maywood, N.J.), 2009, Volume: 234, Issue:7

    Topics: Action Potentials; Animals; Barium Compounds; Chlorides; Chromans; Glyburide; Guinea Pigs; Heart Atria; Male; Membrane Potentials; Myocytes, Cardiac; Patch-Clamp Techniques; Phenethylamines; Phosphines; Potassium Channel Blockers; Refractory Period, Electrophysiological; Stress, Mechanical; Sulfonamides

2009