Page last updated: 2024-08-25

uk 68798 and flecainide

uk 68798 has been researched along with flecainide in 29 studies

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (13.79)18.2507
2000's16 (55.17)29.6817
2010's8 (27.59)24.3611
2020's1 (3.45)2.80

Authors

AuthorsStudies
Baizman, ER; Becker, C; Bell, RH; Birsner, NC; Bohnet, EA; Busacca, CA; Carabateas, PM; Chadwick, CC; Gruett, MD; Johnson, RE1
Topliss, JG; Yoshida, F1
Keserü, GM1
Nagashima, R; Nishikawa, T; Tobita, M1
Lombardo, F; Obach, RS; Waters, NJ1
Jia, L; Sun, H1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Brown, AM; Bruening-Wright, A; Kramer, J; Kuryshev, YA; Myatt, G; Obejero-Paz, CA; Verducci, JS1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Crijns, HJ; Dunselman, PH; Gosselink, AT; Kingma, JH; Lie, KI; Van Gelder, IC1
Bril, A; Feuerstein, GZ; Gout, B; Nichols, AJ1
Martin, CL; Mcmahon, EG; Palomo, MA1
Knobloch, K; Wirth, KJ1
Nattel, S; Schram, G; Shinagawa, K; Shiroshita-Takeshita, A1
Bhatta, L; Hynes, J; Khan, M; Luck, J; Naccarelli, GV; Samii, S; Wolbrette, DL1
Kao, W; Kowey, PR; Winkel, E; Yan, GX1
Mounsey, JP; VerNooy, RA1
Bleich, M; Brendel, J; Busch, AE; Knobloch, K; Rosenstein, B; Wirth, KJ1
Akhtar, M; Narayan, G; Sra, J1
Leung, TK; Nattel, S; Rivard, L; Schram, G; Shiroshita-Takeshita, A; Sinno, H1
Bernard, M; Bril, A; Chalvidan, T; Cozma, D; Cozzone, P; Deharo, JC; Djiane, P; Gout, B; Kalifa, J; Laurent, P; Maixent, JM1
Bauman, JL; Kehoe, RF; Leal, S; Mykytsey, A; Razminia, M; Saleem, M; Wang, T; Zheutlin, T1
DU, CY; El Harchi, A; Hancox, JC; Orchard, CH; Zhang, YH1
Eggertson, L1
Fukuda, K; Hashimoto, N; Ishiwata, N; Kobayashi, T; Machida, T; Matsuura, J; Miyoshi, S; Nakaya, H; Ogawa, S; Ogino, Y; Tanimoto, K; Yamamoto, W; Yamanaka, Y; Yamashita, T1
Osadchii, OE2

Reviews

4 review(s) available for uk 68798 and flecainide

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Old and new antiarrhythmic drugs for converting and maintaining sinus rhythm in atrial fibrillation: comparative efficacy and results of trials.
    The American journal of cardiology, 2003, Mar-20, Volume: 91, Issue:6A

    Topics: Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Australia; Canada; Controlled Clinical Trials as Topic; Europe; Flecainide; Heart Conduction System; Heart Failure; Humans; Multicenter Studies as Topic; Myocardial Infarction; Phenethylamines; Propafenone; Quinidine; Sotalol; Sulfonamides; Survival Analysis; Therapeutic Equivalency; Treatment Outcome; United States

2003
Pharmacologic and nonpharmacologic options to maintain sinus rhythm: guideline-based and new approaches.
    The American journal of cardiology, 2003, Mar-20, Volume: 91, Issue:6A

    Topics: Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Cardiac Pacing, Artificial; Catheter Ablation; Flecainide; Heart Rate; Humans; Phenethylamines; Practice Guidelines as Topic; Propafenone; Quinidine; Stroke; Sulfonamides; Ventricular Dysfunction, Left

2003
Antiarrhythmic drug therapy of atrial fibrillation.
    Cardiology clinics, 2004, Volume: 22, Issue:1

    Topics: Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Disopyramide; Flecainide; Humans; Phenethylamines; Sotalol; Sulfonamides

2004

Trials

2 trial(s) available for uk 68798 and flecainide

ArticleYear
Atrial flutter can be terminated by a class III antiarrhythmic drug but not by a class IC drug.
    European heart journal, 1994, Volume: 15, Issue:10

    Topics: Anti-Arrhythmia Agents; Atrial Flutter; Double-Blind Method; Echocardiography; Electrocardiography; Female; Flecainide; Heart Conduction System; Humans; Infusions, Intravenous; Male; Middle Aged; Phenethylamines; Sulfonamides

1994
Observations on the safety and effectiveness of dofetilide in patients with paroxysmal atrial fibrillation and normal left ventricular function.
    Journal of cardiovascular pharmacology and therapeutics, 2007, Volume: 12, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Dose-Response Relationship, Drug; Drug Monitoring; Female; Flecainide; Follow-Up Studies; Humans; Inpatients; Long QT Syndrome; Male; Middle Aged; Phenethylamines; Propafenone; Recurrence; Sotalol; Sulfonamides; Tachycardia, Ventricular; Treatment Outcome; Ventricular Function, Left; Withholding Treatment

2007

Other Studies

23 other study(ies) available for uk 68798 and flecainide

ArticleYear
4,5-Dihydro-1-phenyl-1H-2,4-benzodiazepines: novel antiarrhythmic agents.
    Journal of medicinal chemistry, 1993, Oct-29, Volume: 36, Issue:22

    Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzodiazepines; Cats; Disease Models, Animal; Dogs; Guinea Pigs; Heart Ventricles; Male; Myocardial Contraction; Myocardial Infarction; Potassium Channels; Rats; Rats, Sprague-Dawley; Refractory Period, Electrophysiological; Sodium Channels; Structure-Activity Relationship

1993
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
    Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16

    Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship

2003
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
    Bioorganic & medicinal chemistry letters, 2005, Jun-02, Volume: 15, Issue:11

    Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated

2005
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Support vector machines classification of hERG liabilities based on atom types.
    Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11

    Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
MICE models: superior to the HERG model in predicting Torsade de Pointes.
    Scientific reports, 2013, Volume: 3

    Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Theoretical; Patch-Clamp Techniques; Predictive Value of Tests; Torsades de Pointes

2013
Antifibrillatory effects of BRL-32872 in anesthetized Yucatan minipigs with regional myocardial ischemia.
    Journal of cardiovascular pharmacology, 1995, Volume: 26, Issue:4

    Topics: Analysis of Variance; Animals; Anti-Arrhythmia Agents; Benzamides; Disease Models, Animal; Flecainide; Injections, Intravenous; Myocardial Ischemia; Myocardial Reperfusion Injury; Phenethylamines; Sulfonamides; Swine; Swine, Miniature; Ventricular Fibrillation

1995
Comparison of bidisomide, flecainide and dofetilide on action potential duration in isolated canine atria: effect of isoproterenol.
    The Journal of pharmacology and experimental therapeutics, 1996, Volume: 278, Issue:1

    Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Dogs; Dose-Response Relationship, Drug; Flecainide; Guinea Pigs; Heart Atria; Isoproterenol; Male; Phenethylamines; Piperidines; Sulfonamides

1996
Differential effects of dofetilide, amiodarone, and class lc drugs on left and right atrial refractoriness and left atrial vulnerability in pigs.
    Naunyn-Schmiedeberg's archives of pharmacology, 2001, Volume: 363, Issue:2

    Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Atrial Function, Left; Atrial Function, Right; Flecainide; Male; Phenethylamines; Propafenone; Sulfonamides; Swine

2001
Effects of antiarrhythmic drugs on fibrillation in the remodeled atrium: insights into the mechanism of the superior efficacy of amiodarone.
    Circulation, 2003, Mar-18, Volume: 107, Issue:10

    Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Calcium Channels, L-Type; Dogs; Electrocardiography; Electrophysiology; Flecainide; Heart Atria; Phenethylamines; Refractory Period, Electrophysiological; Sulfonamides; Tachycardia

2003
Atrial-selective antiarrhythmic actions of novel Ikur vs. Ikr, Iks, and IKAch class Ic drugs and beta blockers in pigs.
    Medical science monitor : international medical journal of experimental and clinical research, 2004, Volume: 10, Issue:7

    Topics: Adrenergic beta-Antagonists; Amiodarone; Animals; Anti-Arrhythmia Agents; Atrial Function; Atropine; Biphenyl Compounds; Chromans; Flecainide; Heart Atria; Hydantoins; Imidazoles; Imidazolidines; Male; Phenethylamines; Piperazines; Potassium Channel Blockers; Potassium Channels; Propafenone; Propanolamines; Sotalol; Sulfonamides; Swine; Ventricular Function

2004
Combined use of 1C and III agents for highly symptomatic, refractory atrial fibrillation.
    Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2006, Volume: 15, Issue:3

    Topics: Adult; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Chronic Disease; Drug Combinations; Female; Flecainide; Humans; Male; Middle Aged; Phenethylamines; Propafenone; Secondary Prevention; Sotalol; Sulfonamides; Treatment Failure; Treatment Outcome

2006
The pharmacological response of ischemia-related atrial fibrillation in dogs: evidence for substrate-specific efficacy.
    Cardiovascular research, 2007, Apr-01, Volume: 74, Issue:1

    Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Calcium Channel Blockers; Coronary Disease; Diltiazem; Dogs; Electric Stimulation; Flecainide; Models, Animal; Nadolol; Phenethylamines; Potassium Channel Blockers; Refractory Period, Electrophysiological; Sodium Channel Blockers; Sulfonamides; Vagus Nerve

2007
Anti-arrhythmic effects of I (Na), I (Kr), and combined I (Kr)-I (CaL) blockade in an experimental model of acute stretch-related atrial fibrillation.
    Cardiovascular drugs and therapy, 2007, Volume: 21, Issue:1

    Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Function; Benzamides; Dose-Response Relationship, Drug; Electrophysiologic Techniques, Cardiac; Female; Flecainide; In Vitro Techniques; Male; Myocardial Contraction; Perfusion; Phenethylamines; Potassium Channels, Calcium-Activated; Potassium Channels, Inwardly Rectifying; Rabbits; Sodium Channel Blockers; Stress, Mechanical; Sulfonamides; Time Factors

2007
Pharmacological inhibition of the hERG potassium channel is modulated by extracellular but not intracellular acidosis.
    Journal of cardiovascular electrophysiology, 2011, Volume: 22, Issue:10

    Topics: Acidosis; Amiodarone; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Flecainide; HEK293 Cells; Humans; Hydrogen-Ion Concentration; Membrane Potentials; Patch-Clamp Techniques; Phenethylamines; Potassium; Potassium Channel Blockers; Sulfonamides; Time Factors; Transfection

2011
Three heart medications in short supply in Canada.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2014, Mar-18, Volume: 186, Issue:5

    Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Canada; Flecainide; Humans; Phenethylamines; Propafenone; Sulfonamides

2014
Effects of the selective KACh channel blocker NTC-801 on atrial fibrillation in a canine model of atrial tachypacing: comparison with class Ic and III drugs.
    Journal of cardiovascular pharmacology, 2014, Volume: 63, Issue:5

    Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Cardiac Pacing, Artificial; Dogs; Electrocardiography; Flecainide; Heart Atria; Heart Conduction System; Phenethylamines; Potassium Channel Blockers; Receptors, Cholinergic; Sulfonamides; Tachycardia

2014
Arrhythmogenic drugs can amplify spatial heterogeneities in the electrical restitution in perfused guinea-pig heart: An evidence from assessments of monophasic action potential durations and JT intervals.
    PloS one, 2018, Volume: 13, Issue:1

    Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrophysiological Phenomena; Female; Flecainide; Guinea Pigs; In Vitro Techniques; Perfusion; Phenethylamines; Procainamide; Quinidine; Sulfonamides

2018
Antiarrhythmic drug effects on premature beats are partly determined by prior cardiac activation frequency in perfused guinea-pig heart.
    Experimental physiology, 2020, Volume: 105, Issue:5

    Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Electrophysiological Phenomena; Female; Flecainide; Guinea Pigs; Heart; Heart Rate; In Vitro Techniques; Phenethylamines; Procainamide; Quinidine; Sulfonamides

2020