Page last updated: 2024-08-25

uk 68798 and e 4031

uk 68798 has been researched along with e 4031 in 36 studies

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's20 (55.56)18.2507
2000's13 (36.11)29.6817
2010's2 (5.56)24.3611
2020's1 (2.78)2.80

Authors

AuthorsStudies
Baldwin, JJ; Buhrow, SA; Butcher, JW; Claremon, DA; Elliott, JM; Habecker, CN; King, SW; Lynch, JJ; Phillips, BT; Selnick, HG1
Bagli, JF; Ellingboe, JW; Kitzen, JM; Moubarak, IF; Nguyen, TT; Parsons, RW; Spinelli, W; Von Engen, D; Winkley, MW1
Anantharaman, V; Bagli, JF; Butera, JA; Cullinan, C; Marcopulos, N; Moubarak, IF; Parsons, RW; Spinelli, W1
Chung, YS; Jeon, GH; Jung, KY; Kim, DI; Kim, HY; Kozono, T; Kwon, LS; Lee, K; Min, JK; Nam, WH; Park, SD; Tanabe, S1
Kanojia, RM; Kauffman, J; Salata, JJ1
Cavalli, A; De Ponti, F; Poluzzi, E; Recanatini, M1
Keserü, GM1
Du, LP; Li, MY; Tsai, KC; Xia, L; You, QD1
Nagashima, R; Nishikawa, T; Tobita, M1
Bianucci, AM; Calderone, V; Coi, A; Massarelli, I; Testai, L1
Jia, L; Sun, H1
Caron, G; Ermondi, G; Visentin, S1
Fijorek, K; Glinka, A; Mendyk, A; Polak, S; Wiśniowska, B1
Colatsky, TJ; Parsons, RW; Spinelli, W1
Sanguinetti, MC1
Baskin, EP; Brookes, LM; Claremon, DA; Lynch, JJ; Selnick, HG; Serik, CM; Wallace, AA1
Brookes, LM; Claremon, DA; Lynch, JJ; Selnick, HG; Stupienski, RF; Wallace, AA1
Brunden, MN; Buchanan, LV; Gibson, JK; Kabell, G1
Krafte, DS; Volberg, WA1
Baskin, EP; Lynch, JJ2
Baskin, EP; Guinosso, PJ; Hamill, T; Lynch, JJ; Nutt, EM; Salata, JJ; Woods, CM1
Colatsky, TJ; Moubarak, IF; Parsons, RW; Spinelli, W1
Abrahamsson, C; Carlsson, L; Duker, G; Lundberg, C1
Lee, EW; Lee, KS; Tsai, TD1
Mitamura, H; Ogawa, S; Okada, Y; Sadanaga, T1
Chiba, S; Furukawa, Y; Hoyano, Y; Imamura, H; Kasama, M; Yonezawa, T1
Bril, A; Faivre, JF; Rouanet, S1
Bianchi, L; Castaldo, P; Emmi, A; Janigro, D; Nerbonne, J; Robertson, GA; Schwartzkroin, PA; Taglialatela, M; Wenzel, HJ1
January, CT; Xie, JT; Yuan, CS; Zhou, Z1
Kondo, M; Mashima, S; Tsutsumi, T1
Endoh, M; Ishii, K; Nagai, M; Takahashi, M1
de Groot, MJ; Helliwell, R; Leishman, D; Mitcheson, J; Perry, M; Sanguinetti, MC; Tristani-Firouzi, M1
Kamiya, K; Mitcheson, JS; Niwa, R; Sanguinetti, MC1
Beekman, JD; de Boer, TP; Duker, G; Houtman, MJ; Jonsson, MK; Nalos, L; Peschar, M; Rook, MB; Sartipy, P; Thomsen, MB; van der Heyden, MA; van der Nagel, R; van Veen, TA; Varkevisser, R; Vos, MA1
Charpentier, F; De Waard, M; De Waard, S; Forest, V; Gaborit, N; Lemarchand, P; Loussouarn, G; Mangoni, ME; Montnach, J; Nicolas, S; Ribeiro, B; Ronjat, M1

Reviews

1 review(s) available for uk 68798 and e 4031

ArticleYear
Modulation of potassium channels by antiarrhythmic and antihypertensive drugs.
    Hypertension (Dallas, Tex. : 1979), 1992, Volume: 19, Issue:3

    Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Muscle, Smooth; Phenethylamines; Piperidines; Potassium Channels; Pyridines; Sulfonamides

1992

Trials

1 trial(s) available for uk 68798 and e 4031

ArticleYear
Assessment of reverse use-dependent blocking actions of class III antiarrhythmic drugs by 24-hour Holter electrocardiography.
    Journal of the American College of Cardiology, 1996, Volume: 27, Issue:1

    Topics: Adult; Aged; Analysis of Variance; Anti-Arrhythmia Agents; Electrocardiography, Ambulatory; Female; Humans; Long QT Syndrome; Male; Middle Aged; Phenethylamines; Piperidines; Pyridines; Pyrimidinones; Regression Analysis; Sotalol; Statistics, Nonparametric; Sulfonamides

1996

Other Studies

34 other study(ies) available for uk 68798 and e 4031

ArticleYear
4-Oxospiro[benzopyran-2,4'-piperidines] as class III antiarrhythmic agents. Pharmacological studies on 3,4-dihydro-1'-[2-(benzofurazan-5-yl)- ethyl]-6-methanesulfonamidospiro[(2H)-1-benzopyran-2,4'-piperidin]-4-on e (L-691,121).
    Journal of medicinal chemistry, 1992, Oct-16, Volume: 35, Issue:21

    Topics: Animals; Anti-Arrhythmia Agents; Dogs; Piperidones; Spiro Compounds; Structure-Activity Relationship

1992
Class III antiarrhythmic activity of novel substituted 4-[(methylsulfonyl)amino]benzamides and sulfonamides.
    Journal of medicinal chemistry, 1992, Feb-21, Volume: 35, Issue:4

    Topics: Action Potentials; Anti-Arrhythmia Agents; Atrial Function; Benzamides; Benzimidazoles; Biological Availability; Electric Conductivity; Heart Atria; Heart Conduction System; Heart Ventricles; Membrane Potentials; Molecular Structure; Myocardial Contraction; Purkinje Fibers; Structure-Activity Relationship; Sulfanilamides; Sulfonamides; Ventricular Fibrillation; Ventricular Function

1992
Synthesis and selective class III antiarrhythmic activity of novel N-heteroaralkyl-substituted 1-(aryloxy)-2-propanolamine and related propylamine derivatives.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:11

    Topics: Animals; Anti-Arrhythmia Agents; Cats; Dogs; Electrophysiology; Guinea Pigs; Membrane Potentials; Propanolamines; Propylamines; Purkinje Fibers; Quinolines; Structure-Activity Relationship

1991
Synthesis and biological activity of KCB-328 and its analogues: novel class III antiarrhythmic agents with little reverse frequency dependence.
    Bioorganic & medicinal chemistry letters, 1999, Jan-04, Volume: 9, Issue:1

    Topics: Animals; Anti-Arrhythmia Agents; Drug Evaluation, Preclinical; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Myocardial Contraction; Papillary Muscles; Phenethylamines; Structure-Activity Relationship; Sulfonamides

1999
Synthesis and class III type antiarrhythmic activity of 4-aroyl (and aryl)-l-aralkylpiperazines.
    Bioorganic & medicinal chemistry letters, 2000, Dec-18, Volume: 10, Issue:24

    Topics: Animals; Anti-Arrhythmia Agents; Biological Assay; Ferrets; In Vitro Techniques; Isometric Contraction; Male; Papillary Muscles; Piperazines; Piperidines; Structure-Activity Relationship

2000
Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers.
    Journal of medicinal chemistry, 2002, Aug-29, Volume: 45, Issue:18

    Topics: Anti-Arrhythmia Agents; Cation Transport Proteins; Cluster Analysis; Databases, Factual; Ether-A-Go-Go Potassium Channels; Long QT Syndrome; Models, Molecular; Molecular Conformation; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship

2002
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
    Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16

    Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship

2003
The pharmacophore hypotheses of I(Kr) potassium channel blockers: novel class III antiarrhythmic agents.
    Bioorganic & medicinal chemistry letters, 2004, Sep-20, Volume: 14, Issue:18

    Topics: Anti-Arrhythmia Agents; Models, Biological; Models, Molecular; Potassium Channel Blockers; Potassium Channels; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical

2004
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
    Bioorganic & medicinal chemistry letters, 2005, Jun-02, Volume: 15, Issue:11

    Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated

2005
Identification of "toxicophoric" features for predicting drug-induced QT interval prolongation.
    European journal of medicinal chemistry, 2008, Volume: 43, Issue:11

    Topics: Amino Acid Sequence; Heart; Humans; Models, Molecular; Molecular Sequence Data; Molecular Structure; Protein Subunits; Sequence Alignment; Structure-Activity Relationship; Trans-Activators; Transcriptional Regulator ERG

2008
Support vector machines classification of hERG liabilities based on atom types.
    Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11

    Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve

2008
GRIND-based 3D-QSAR and CoMFA to investigate topics dominated by hydrophobic interactions: the case of hERG K+ channel blockers.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:5

    Topics: Ether-A-Go-Go Potassium Channels; Humans; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Potassium Channel Blockers; Quantitative Structure-Activity Relationship

2009
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment.
    Journal of applied toxicology : JAT, 2012, Volume: 32, Issue:10

    Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computational Biology; Computer Simulation; Drugs, Investigational; Ether-A-Go-Go Potassium Channels; Expert Systems; Heart Rate; Humans; Models, Biological; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Potassium Channel Blockers; Quantitative Structure-Activity Relationship; Risk Assessment; Shaker Superfamily of Potassium Channels; Torsades de Pointes; Voltage-Gated Sodium Channel Blockers

2012
Effects of WAY-123,398, a new class III antiarrhythmic agent, on cardiac refractoriness and ventricular fibrillation threshold in anesthetized dogs: a comparison with UK-68798, E-4031, and dl-sotalol.
    Journal of cardiovascular pharmacology, 1992, Volume: 20, Issue:6

    Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Atrioventricular Node; Benzimidazoles; Dogs; Electrocardiography; Electrophysiology; Female; Heart; Heart Conduction System; Hemodynamics; In Vitro Techniques; Male; Phenethylamines; Piperidines; Purkinje Fibers; Pyridines; Refractory Period, Electrophysiological; Sotalol; Sulfanilamides; Sulfonamides; Ventricular Fibrillation

1992
Effects of new and potent methanesulfonanilide class III antiarrhythmic agents on myocardial refractoriness and contractility in isolated cardiac muscle.
    Journal of cardiovascular pharmacology, 1991, Volume: 18, Issue:3

    Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Ferrets; Heart; Hypoxia; In Vitro Techniques; Male; Myocardial Contraction; Phenethylamines; Piperidines; Pyrazines; Pyridines; Refractory Period, Electrophysiological; Sotalol; Sulfonamides; Temperature

1991
Cardiac electrophysiologic and inotropic actions of new and potent methanesulfonanilide class III antiarrhythmic agents in anesthetized dogs.
    Journal of cardiovascular pharmacology, 1991, Volume: 18, Issue:5

    Topics: Animals; Anti-Arrhythmia Agents; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Electrophysiology; Female; Heart; Hemodynamics; Male; Myocardial Contraction; Phenethylamines; Piperidines; Pyrazines; Pyridines; Refractory Period, Electrophysiological; Sotalol; Sulfonamides

1991
Comparative assessment of ibutilide, D-sotalol, clofilium, E-4031, and UK-68,798 in a rabbit model of proarrhythmia.
    Journal of cardiovascular pharmacology, 1993, Volume: 22, Issue:4

    Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Electrocardiography; Heart Conduction System; Heart Rate; Male; Methoxamine; Phenethylamines; Piperidines; Pyridines; Quaternary Ammonium Compounds; Rabbits; Software; Sotalol; Sulfonamides; Torsades de Pointes

1993
Voltage dependence of cardiac delayed rectifier block by methanesulfonamide class III antiarrhythmic agents.
    Journal of cardiovascular pharmacology, 1994, Volume: 23, Issue:1

    Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Electrophysiology; Guinea Pigs; Heart Ventricles; In Vitro Techniques; Phenethylamines; Piperidines; Procainamide; Pyridines; Sotalol; Stereoisomerism; Sulfonamides; Ventricular Function

1994
Comparative effects of increased extracellular potassium and pacing frequency on the class III activities of methanesulfonanilide IKr blockers dofetilide, D-sotalol, E-4031, and MK-499.
    Journal of cardiovascular pharmacology, 1994, Volume: 24, Issue:2

    Topics: Animals; Anti-Arrhythmia Agents; Benzopyrans; Electric Stimulation; Ferrets; Male; Phenethylamines; Piperidines; Potassium; Potassium Channel Blockers; Pyridines; Refractory Period, Electrophysiological; Sotalol; Sulfonamides

1994
Comparison of binding to rapidly activating delayed rectifier K+ channel, IKr, and effects on myocardial refractoriness for class III antiarrhythmic agents.
    Journal of cardiovascular pharmacology, 1995, Volume: 25, Issue:2

    Topics: Animals; Anti-Arrhythmia Agents; Binding, Competitive; Chromans; Electrophysiology; Guinea Pigs; Heart Ventricles; Papillary Muscles; Phenethylamines; Piperidines; Potassium Channel Blockers; Potassium Channels; Procainamide; Pyridines; Sotalol; Structure-Activity Relationship; Sulfonamides; Tritium

1995
Cellular electrophysiology of WAY-123,398, a new class III antiarrhythmic agent: specificity of IK block and lack of reverse use dependence in cat ventricular myocytes.
    Cardiovascular research, 1993, Volume: 27, Issue:9

    Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Benzimidazoles; Cats; Cells, Cultured; Culture Techniques; Dogs; Dose-Response Relationship, Drug; Myocardium; Phenethylamines; Piperidines; Potassium Channels; Purkinje Fibers; Pyridines; Sotalol; Sulfanilamides; Sulfonamides

1993
Electrophysiological and inotropic effects of H 234/09 (almokalant) in vitro: a comparison with two other novel IK blocking drugs, UK-68,798 (dofetilide) and E-4031.
    Cardiovascular research, 1993, Volume: 27, Issue:5

    Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Cats; Dose-Response Relationship, Drug; Heart; In Vitro Techniques; Male; Myocardial Contraction; Papillary Muscles; Phenethylamines; Piperidines; Propanolamines; Purkinje Fibers; Pyridines; Rabbits; Stimulation, Chemical; Sulfonamides

1993
Membrane activity of class III antiarrhythmic compounds; a comparison between ibutilide, d-sotalol, E-4031, sematilide and dofetilide.
    European journal of pharmacology, 1993, Mar-30, Volume: 234, Issue:1

    Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Guinea Pigs; Heart; In Vitro Techniques; Membrane Potentials; Phenethylamines; Piperidines; Potassium Channels; Procainamide; Pyridines; Sotalol; Sulfonamides

1993
Inhibition of delayed rectifier K+ current by dofetilide and E-4031 differentially affects electrical cardiac responses to vagus stimulation in anesthetized dogs.
    Japanese journal of pharmacology, 1998, Volume: 76, Issue:1

    Topics: Animals; Anti-Arrhythmia Agents; Bradycardia; Disease Models, Animal; Disopyramide; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Electrophysiology; Female; Heart Conduction System; Male; Phenethylamines; Piperidines; Potassium Channel Blockers; Pyridines; Sulfonamides; Vagus Nerve

1998
Differential atrial versus ventricular activities of class III potassium channel blockers.
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 285, Issue:1

    Topics: Animals; Anti-Arrhythmia Agents; Atrial Function; Ferrets; Heart; Hydantoins; Imidazoles; Imidazolidines; Male; Papillary Muscles; Phenethylamines; Piperazines; Piperidines; Potassium Channel Blockers; Potassium Channels; Pyridines; Sulfonamides; Temperature; Ventricular Function

1998
Comparative effects of glibenclamide, tedisamil, dofetilide, E-4031, and BRL-32872 on protein kinase A-activated chloride current in guinea pig ventricular myocytes.
    Journal of cardiovascular pharmacology, 1998, Volume: 31, Issue:4

    Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; Acetylcholine; Animals; Anti-Arrhythmia Agents; Benzamides; Bridged Bicyclo Compounds, Heterocyclic; Cardiotonic Agents; Chlorides; Cyclic AMP-Dependent Protein Kinases; Cyclopropanes; Glyburide; Guinea Pigs; Heart Ventricles; Hypoglycemic Agents; Ion Transport; Isoproterenol; Male; Myocardium; Patch-Clamp Techniques; Phenethylamines; Piperidines; Potassium Channels; Propranolol; Pyridines; Sulfonamides

1998
Do glia have heart? Expression and functional role for ether-a-go-go currents in hippocampal astrocytes.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, May-15, Volume: 20, Issue:10

    Topics: Animals; Anti-Arrhythmia Agents; Astrocytes; Cation Transport Proteins; Cell Communication; Cesium; Dose-Response Relationship, Drug; Electrophysiology; Epilepsy; Ether-A-Go-Go Potassium Channels; Gene Expression; Heart; Hippocampus; In Vitro Techniques; Long QT Syndrome; Male; Membrane Potentials; Microscopy, Electron; Neurons; Oligonucleotide Probes; Phenethylamines; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Rats; Rats, Wistar; RNA, Messenger; Spinal Cord; Sulfonamides

2000
Enhancement of delayed afterdepolarizations and triggered activity by class III antiarrhythmic drugs: multiple effects of E-4031 and dofetilide.
    Methods and findings in experimental and clinical pharmacology, 2000, Volume: 22, Issue:2

    Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Phenethylamines; Piperidines; Purkinje Fibers; Pyridines; Sheep; Sulfonamides; Time Factors

2000
Potassium channel openers antagonize the effects of class III antiarrhythmic agents in canine Purkinje fiber action potentials. Implications for prevention of proarrhythmia induced by class III agents.
    Japanese heart journal, 1999, Volume: 40, Issue:5

    Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dogs; Phenethylamines; Piperidines; Potassium Channel Blockers; Potassium Channels; Purkinje Fibers; Pyridines; Sulfonamides

1999
Dissociation of E-4031 from the HERG channel caused by mutations of an amino acid results in greater block at high stimulation frequency.
    Cardiovascular research, 2003, Volume: 57, Issue:3

    Topics: Animals; Anti-Arrhythmia Agents; Cation Transport Proteins; Dose-Response Relationship, Drug; Ether-A-Go-Go Potassium Channels; Isoleucine; Long QT Syndrome; Mutagenesis, Site-Directed; Oocytes; Patch-Clamp Techniques; Phenethylamines; Piperidines; Point Mutation; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Sulfonamides; Xenopus

2003
Structural determinants of HERG channel block by clofilium and ibutilide.
    Molecular pharmacology, 2004, Volume: 66, Issue:2

    Topics: Amino Acid Substitution; Animals; Anti-Arrhythmia Agents; Aspartic Acid; Benzopyrans; Binding Sites; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Oocytes; Phenethylamines; Phenylalanine; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Quaternary Ammonium Compounds; Serine; Sulfonamides; Tyrosine; Xenopus laevis

2004
Molecular determinants of HERG channel block.
    Molecular pharmacology, 2006, Volume: 69, Issue:5

    Topics: DNA Primers; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Kinetics; Long QT Syndrome; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Phenethylamines; Piperidines; Potassium Channel Blockers; Pyridines; Recombinant Proteins; Sulfonamides

2006
Comparison of the IKr blockers moxifloxacin, dofetilide and E-4031 in five screening models of pro-arrhythmia reveals lack of specificity of isolated cardiomyocytes.
    British journal of pharmacology, 2012, Volume: 165, Issue:2

    Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Aza Compounds; Cell Line; Disease Models, Animal; Dogs; Embryonic Stem Cells; Female; Fluoroquinolones; Heart; Heart Block; Humans; Methoxamine; Moxifloxacin; Myocytes, Cardiac; Phenethylamines; Piperidines; Potassium Channel Blockers; Pyridines; Quinolines; Rabbits; Sulfonamides; Torsades de Pointes; Ventricular Remodeling

2012
Functional Impact of BeKm-1, a High-Affinity hERG Blocker, on Cardiomyocytes Derived from Human-Induced Pluripotent Stem Cells.
    International journal of molecular sciences, 2020, Sep-28, Volume: 21, Issue:19

    Topics: Action Potentials; Anti-Arrhythmia Agents; Calcium; Calcium Channels; Cell Differentiation; ERG1 Potassium Channel; HEK293 Cells; Humans; Induced Pluripotent Stem Cells; Ion Transport; Long QT Syndrome; Models, Biological; Myocytes, Cardiac; Patch-Clamp Techniques; Phenethylamines; Piperidines; Potassium; Potassium Channel Blockers; Pyridines; Scorpion Venoms; Sulfonamides

2020