uk 68798 has been researched along with e 4031 in 36 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 20 (55.56) | 18.2507 |
| 2000's | 13 (36.11) | 29.6817 |
| 2010's | 2 (5.56) | 24.3611 |
| 2020's | 1 (2.78) | 2.80 |
| Authors | Studies |
|---|---|
| Baldwin, JJ; Buhrow, SA; Butcher, JW; Claremon, DA; Elliott, JM; Habecker, CN; King, SW; Lynch, JJ; Phillips, BT; Selnick, HG | 1 |
| Bagli, JF; Ellingboe, JW; Kitzen, JM; Moubarak, IF; Nguyen, TT; Parsons, RW; Spinelli, W; Von Engen, D; Winkley, MW | 1 |
| Anantharaman, V; Bagli, JF; Butera, JA; Cullinan, C; Marcopulos, N; Moubarak, IF; Parsons, RW; Spinelli, W | 1 |
| Chung, YS; Jeon, GH; Jung, KY; Kim, DI; Kim, HY; Kozono, T; Kwon, LS; Lee, K; Min, JK; Nam, WH; Park, SD; Tanabe, S | 1 |
| Kanojia, RM; Kauffman, J; Salata, JJ | 1 |
| Cavalli, A; De Ponti, F; Poluzzi, E; Recanatini, M | 1 |
| Keserü, GM | 1 |
| Du, LP; Li, MY; Tsai, KC; Xia, L; You, QD | 1 |
| Nagashima, R; Nishikawa, T; Tobita, M | 1 |
| Bianucci, AM; Calderone, V; Coi, A; Massarelli, I; Testai, L | 1 |
| Jia, L; Sun, H | 1 |
| Caron, G; Ermondi, G; Visentin, S | 1 |
| Fijorek, K; Glinka, A; Mendyk, A; Polak, S; Wiśniowska, B | 1 |
| Colatsky, TJ; Parsons, RW; Spinelli, W | 1 |
| Sanguinetti, MC | 1 |
| Baskin, EP; Brookes, LM; Claremon, DA; Lynch, JJ; Selnick, HG; Serik, CM; Wallace, AA | 1 |
| Brookes, LM; Claremon, DA; Lynch, JJ; Selnick, HG; Stupienski, RF; Wallace, AA | 1 |
| Brunden, MN; Buchanan, LV; Gibson, JK; Kabell, G | 1 |
| Krafte, DS; Volberg, WA | 1 |
| Baskin, EP; Lynch, JJ | 2 |
| Baskin, EP; Guinosso, PJ; Hamill, T; Lynch, JJ; Nutt, EM; Salata, JJ; Woods, CM | 1 |
| Colatsky, TJ; Moubarak, IF; Parsons, RW; Spinelli, W | 1 |
| Abrahamsson, C; Carlsson, L; Duker, G; Lundberg, C | 1 |
| Lee, EW; Lee, KS; Tsai, TD | 1 |
| Mitamura, H; Ogawa, S; Okada, Y; Sadanaga, T | 1 |
| Chiba, S; Furukawa, Y; Hoyano, Y; Imamura, H; Kasama, M; Yonezawa, T | 1 |
| Bril, A; Faivre, JF; Rouanet, S | 1 |
| Bianchi, L; Castaldo, P; Emmi, A; Janigro, D; Nerbonne, J; Robertson, GA; Schwartzkroin, PA; Taglialatela, M; Wenzel, HJ | 1 |
| January, CT; Xie, JT; Yuan, CS; Zhou, Z | 1 |
| Kondo, M; Mashima, S; Tsutsumi, T | 1 |
| Endoh, M; Ishii, K; Nagai, M; Takahashi, M | 1 |
| de Groot, MJ; Helliwell, R; Leishman, D; Mitcheson, J; Perry, M; Sanguinetti, MC; Tristani-Firouzi, M | 1 |
| Kamiya, K; Mitcheson, JS; Niwa, R; Sanguinetti, MC | 1 |
| Beekman, JD; de Boer, TP; Duker, G; Houtman, MJ; Jonsson, MK; Nalos, L; Peschar, M; Rook, MB; Sartipy, P; Thomsen, MB; van der Heyden, MA; van der Nagel, R; van Veen, TA; Varkevisser, R; Vos, MA | 1 |
| Charpentier, F; De Waard, M; De Waard, S; Forest, V; Gaborit, N; Lemarchand, P; Loussouarn, G; Mangoni, ME; Montnach, J; Nicolas, S; Ribeiro, B; Ronjat, M | 1 |
1 review(s) available for uk 68798 and e 4031
| Article | Year |
|---|---|
Modulation of potassium channels by antiarrhythmic and antihypertensive drugs.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Muscle, Smooth; Phenethylamines; Piperidines; Potassium Channels; Pyridines; Sulfonamides | 1992 |
1 trial(s) available for uk 68798 and e 4031
| Article | Year |
|---|---|
Assessment of reverse use-dependent blocking actions of class III antiarrhythmic drugs by 24-hour Holter electrocardiography.
Topics: Adult; Aged; Analysis of Variance; Anti-Arrhythmia Agents; Electrocardiography, Ambulatory; Female; Humans; Long QT Syndrome; Male; Middle Aged; Phenethylamines; Piperidines; Pyridines; Pyrimidinones; Regression Analysis; Sotalol; Statistics, Nonparametric; Sulfonamides | 1996 |
34 other study(ies) available for uk 68798 and e 4031
| Article | Year |
|---|---|
4-Oxospiro[benzopyran-2,4'-piperidines] as class III antiarrhythmic agents. Pharmacological studies on 3,4-dihydro-1'-[2-(benzofurazan-5-yl)- ethyl]-6-methanesulfonamidospiro[(2H)-1-benzopyran-2,4'-piperidin]-4-on e (L-691,121).
Topics: Animals; Anti-Arrhythmia Agents; Dogs; Piperidones; Spiro Compounds; Structure-Activity Relationship | 1992 |
Class III antiarrhythmic activity of novel substituted 4-[(methylsulfonyl)amino]benzamides and sulfonamides.
Topics: Action Potentials; Anti-Arrhythmia Agents; Atrial Function; Benzamides; Benzimidazoles; Biological Availability; Electric Conductivity; Heart Atria; Heart Conduction System; Heart Ventricles; Membrane Potentials; Molecular Structure; Myocardial Contraction; Purkinje Fibers; Structure-Activity Relationship; Sulfanilamides; Sulfonamides; Ventricular Fibrillation; Ventricular Function | 1992 |
Synthesis and selective class III antiarrhythmic activity of novel N-heteroaralkyl-substituted 1-(aryloxy)-2-propanolamine and related propylamine derivatives.
Topics: Animals; Anti-Arrhythmia Agents; Cats; Dogs; Electrophysiology; Guinea Pigs; Membrane Potentials; Propanolamines; Propylamines; Purkinje Fibers; Quinolines; Structure-Activity Relationship | 1991 |
Synthesis and biological activity of KCB-328 and its analogues: novel class III antiarrhythmic agents with little reverse frequency dependence.
Topics: Animals; Anti-Arrhythmia Agents; Drug Evaluation, Preclinical; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Myocardial Contraction; Papillary Muscles; Phenethylamines; Structure-Activity Relationship; Sulfonamides | 1999 |
Synthesis and class III type antiarrhythmic activity of 4-aroyl (and aryl)-l-aralkylpiperazines.
Topics: Animals; Anti-Arrhythmia Agents; Biological Assay; Ferrets; In Vitro Techniques; Isometric Contraction; Male; Papillary Muscles; Piperazines; Piperidines; Structure-Activity Relationship | 2000 |
Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers.
Topics: Anti-Arrhythmia Agents; Cation Transport Proteins; Cluster Analysis; Databases, Factual; Ether-A-Go-Go Potassium Channels; Long QT Syndrome; Models, Molecular; Molecular Conformation; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship | 2002 |
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship | 2003 |
The pharmacophore hypotheses of I(Kr) potassium channel blockers: novel class III antiarrhythmic agents.
Topics: Anti-Arrhythmia Agents; Models, Biological; Models, Molecular; Potassium Channel Blockers; Potassium Channels; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2004 |
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated | 2005 |
Identification of "toxicophoric" features for predicting drug-induced QT interval prolongation.
Topics: Amino Acid Sequence; Heart; Humans; Models, Molecular; Molecular Sequence Data; Molecular Structure; Protein Subunits; Sequence Alignment; Structure-Activity Relationship; Trans-Activators; Transcriptional Regulator ERG | 2008 |
Support vector machines classification of hERG liabilities based on atom types.
Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve | 2008 |
GRIND-based 3D-QSAR and CoMFA to investigate topics dominated by hydrophobic interactions: the case of hERG K+ channel blockers.
Topics: Ether-A-Go-Go Potassium Channels; Humans; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Potassium Channel Blockers; Quantitative Structure-Activity Relationship | 2009 |
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment.
Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computational Biology; Computer Simulation; Drugs, Investigational; Ether-A-Go-Go Potassium Channels; Expert Systems; Heart Rate; Humans; Models, Biological; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Potassium Channel Blockers; Quantitative Structure-Activity Relationship; Risk Assessment; Shaker Superfamily of Potassium Channels; Torsades de Pointes; Voltage-Gated Sodium Channel Blockers | 2012 |
Effects of WAY-123,398, a new class III antiarrhythmic agent, on cardiac refractoriness and ventricular fibrillation threshold in anesthetized dogs: a comparison with UK-68798, E-4031, and dl-sotalol.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Atrioventricular Node; Benzimidazoles; Dogs; Electrocardiography; Electrophysiology; Female; Heart; Heart Conduction System; Hemodynamics; In Vitro Techniques; Male; Phenethylamines; Piperidines; Purkinje Fibers; Pyridines; Refractory Period, Electrophysiological; Sotalol; Sulfanilamides; Sulfonamides; Ventricular Fibrillation | 1992 |
Effects of new and potent methanesulfonanilide class III antiarrhythmic agents on myocardial refractoriness and contractility in isolated cardiac muscle.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Ferrets; Heart; Hypoxia; In Vitro Techniques; Male; Myocardial Contraction; Phenethylamines; Piperidines; Pyrazines; Pyridines; Refractory Period, Electrophysiological; Sotalol; Sulfonamides; Temperature | 1991 |
Cardiac electrophysiologic and inotropic actions of new and potent methanesulfonanilide class III antiarrhythmic agents in anesthetized dogs.
Topics: Animals; Anti-Arrhythmia Agents; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Electrophysiology; Female; Heart; Hemodynamics; Male; Myocardial Contraction; Phenethylamines; Piperidines; Pyrazines; Pyridines; Refractory Period, Electrophysiological; Sotalol; Sulfonamides | 1991 |
Comparative assessment of ibutilide, D-sotalol, clofilium, E-4031, and UK-68,798 in a rabbit model of proarrhythmia.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Electrocardiography; Heart Conduction System; Heart Rate; Male; Methoxamine; Phenethylamines; Piperidines; Pyridines; Quaternary Ammonium Compounds; Rabbits; Software; Sotalol; Sulfonamides; Torsades de Pointes | 1993 |
Voltage dependence of cardiac delayed rectifier block by methanesulfonamide class III antiarrhythmic agents.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Electrophysiology; Guinea Pigs; Heart Ventricles; In Vitro Techniques; Phenethylamines; Piperidines; Procainamide; Pyridines; Sotalol; Stereoisomerism; Sulfonamides; Ventricular Function | 1994 |
Comparative effects of increased extracellular potassium and pacing frequency on the class III activities of methanesulfonanilide IKr blockers dofetilide, D-sotalol, E-4031, and MK-499.
Topics: Animals; Anti-Arrhythmia Agents; Benzopyrans; Electric Stimulation; Ferrets; Male; Phenethylamines; Piperidines; Potassium; Potassium Channel Blockers; Pyridines; Refractory Period, Electrophysiological; Sotalol; Sulfonamides | 1994 |
Comparison of binding to rapidly activating delayed rectifier K+ channel, IKr, and effects on myocardial refractoriness for class III antiarrhythmic agents.
Topics: Animals; Anti-Arrhythmia Agents; Binding, Competitive; Chromans; Electrophysiology; Guinea Pigs; Heart Ventricles; Papillary Muscles; Phenethylamines; Piperidines; Potassium Channel Blockers; Potassium Channels; Procainamide; Pyridines; Sotalol; Structure-Activity Relationship; Sulfonamides; Tritium | 1995 |
Cellular electrophysiology of WAY-123,398, a new class III antiarrhythmic agent: specificity of IK block and lack of reverse use dependence in cat ventricular myocytes.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Benzimidazoles; Cats; Cells, Cultured; Culture Techniques; Dogs; Dose-Response Relationship, Drug; Myocardium; Phenethylamines; Piperidines; Potassium Channels; Purkinje Fibers; Pyridines; Sotalol; Sulfanilamides; Sulfonamides | 1993 |
Electrophysiological and inotropic effects of H 234/09 (almokalant) in vitro: a comparison with two other novel IK blocking drugs, UK-68,798 (dofetilide) and E-4031.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Cats; Dose-Response Relationship, Drug; Heart; In Vitro Techniques; Male; Myocardial Contraction; Papillary Muscles; Phenethylamines; Piperidines; Propanolamines; Purkinje Fibers; Pyridines; Rabbits; Stimulation, Chemical; Sulfonamides | 1993 |
Membrane activity of class III antiarrhythmic compounds; a comparison between ibutilide, d-sotalol, E-4031, sematilide and dofetilide.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Guinea Pigs; Heart; In Vitro Techniques; Membrane Potentials; Phenethylamines; Piperidines; Potassium Channels; Procainamide; Pyridines; Sotalol; Sulfonamides | 1993 |
Inhibition of delayed rectifier K+ current by dofetilide and E-4031 differentially affects electrical cardiac responses to vagus stimulation in anesthetized dogs.
Topics: Animals; Anti-Arrhythmia Agents; Bradycardia; Disease Models, Animal; Disopyramide; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Electrophysiology; Female; Heart Conduction System; Male; Phenethylamines; Piperidines; Potassium Channel Blockers; Pyridines; Sulfonamides; Vagus Nerve | 1998 |
Differential atrial versus ventricular activities of class III potassium channel blockers.
Topics: Animals; Anti-Arrhythmia Agents; Atrial Function; Ferrets; Heart; Hydantoins; Imidazoles; Imidazolidines; Male; Papillary Muscles; Phenethylamines; Piperazines; Piperidines; Potassium Channel Blockers; Potassium Channels; Pyridines; Sulfonamides; Temperature; Ventricular Function | 1998 |
Comparative effects of glibenclamide, tedisamil, dofetilide, E-4031, and BRL-32872 on protein kinase A-activated chloride current in guinea pig ventricular myocytes.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; Acetylcholine; Animals; Anti-Arrhythmia Agents; Benzamides; Bridged Bicyclo Compounds, Heterocyclic; Cardiotonic Agents; Chlorides; Cyclic AMP-Dependent Protein Kinases; Cyclopropanes; Glyburide; Guinea Pigs; Heart Ventricles; Hypoglycemic Agents; Ion Transport; Isoproterenol; Male; Myocardium; Patch-Clamp Techniques; Phenethylamines; Piperidines; Potassium Channels; Propranolol; Pyridines; Sulfonamides | 1998 |
Do glia have heart? Expression and functional role for ether-a-go-go currents in hippocampal astrocytes.
Topics: Animals; Anti-Arrhythmia Agents; Astrocytes; Cation Transport Proteins; Cell Communication; Cesium; Dose-Response Relationship, Drug; Electrophysiology; Epilepsy; Ether-A-Go-Go Potassium Channels; Gene Expression; Heart; Hippocampus; In Vitro Techniques; Long QT Syndrome; Male; Membrane Potentials; Microscopy, Electron; Neurons; Oligonucleotide Probes; Phenethylamines; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Rats; Rats, Wistar; RNA, Messenger; Spinal Cord; Sulfonamides | 2000 |
Enhancement of delayed afterdepolarizations and triggered activity by class III antiarrhythmic drugs: multiple effects of E-4031 and dofetilide.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Phenethylamines; Piperidines; Purkinje Fibers; Pyridines; Sheep; Sulfonamides; Time Factors | 2000 |
Potassium channel openers antagonize the effects of class III antiarrhythmic agents in canine Purkinje fiber action potentials. Implications for prevention of proarrhythmia induced by class III agents.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dogs; Phenethylamines; Piperidines; Potassium Channel Blockers; Potassium Channels; Purkinje Fibers; Pyridines; Sulfonamides | 1999 |
Dissociation of E-4031 from the HERG channel caused by mutations of an amino acid results in greater block at high stimulation frequency.
Topics: Animals; Anti-Arrhythmia Agents; Cation Transport Proteins; Dose-Response Relationship, Drug; Ether-A-Go-Go Potassium Channels; Isoleucine; Long QT Syndrome; Mutagenesis, Site-Directed; Oocytes; Patch-Clamp Techniques; Phenethylamines; Piperidines; Point Mutation; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Sulfonamides; Xenopus | 2003 |
Structural determinants of HERG channel block by clofilium and ibutilide.
Topics: Amino Acid Substitution; Animals; Anti-Arrhythmia Agents; Aspartic Acid; Benzopyrans; Binding Sites; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Oocytes; Phenethylamines; Phenylalanine; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Quaternary Ammonium Compounds; Serine; Sulfonamides; Tyrosine; Xenopus laevis | 2004 |
Molecular determinants of HERG channel block.
Topics: DNA Primers; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Kinetics; Long QT Syndrome; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Phenethylamines; Piperidines; Potassium Channel Blockers; Pyridines; Recombinant Proteins; Sulfonamides | 2006 |
Comparison of the IKr blockers moxifloxacin, dofetilide and E-4031 in five screening models of pro-arrhythmia reveals lack of specificity of isolated cardiomyocytes.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Aza Compounds; Cell Line; Disease Models, Animal; Dogs; Embryonic Stem Cells; Female; Fluoroquinolones; Heart; Heart Block; Humans; Methoxamine; Moxifloxacin; Myocytes, Cardiac; Phenethylamines; Piperidines; Potassium Channel Blockers; Pyridines; Quinolines; Rabbits; Sulfonamides; Torsades de Pointes; Ventricular Remodeling | 2012 |
Functional Impact of BeKm-1, a High-Affinity hERG Blocker, on Cardiomyocytes Derived from Human-Induced Pluripotent Stem Cells.
Topics: Action Potentials; Anti-Arrhythmia Agents; Calcium; Calcium Channels; Cell Differentiation; ERG1 Potassium Channel; HEK293 Cells; Humans; Induced Pluripotent Stem Cells; Ion Transport; Long QT Syndrome; Models, Biological; Myocytes, Cardiac; Patch-Clamp Techniques; Phenethylamines; Piperidines; Potassium; Potassium Channel Blockers; Pyridines; Scorpion Venoms; Sulfonamides | 2020 |