Page last updated: 2024-08-25

uk 68798 and digoxin

uk 68798 has been researched along with digoxin in 12 studies

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (41.67)29.6817
2010's7 (58.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lombardo, F; Obach, RS; Waters, NJ1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Boden, WE; Ferraro, P; Khawari, A1
Dalrymple, I; Kleinermans, D; Nichols, DJ1
Corley, SD; DiMarco, JP; Domanski, MJ; Epstein, AE; Geller, N; Greene, HL; Josephson, RA; Kellen, JC; Klein, RC; Krahn, AD; Mickel, M; Mitchell, LB; Nelson, JD; Rosenberg, Y; Schron, E; Shemanski, L; Waldo, AL; Wyse, DG1
Bhavnani, SP; Clyne, CA; Coleman, CI; Guertin, D; Kluger, J; Shafi, NA; White, CM; Yarlagadda, RK1
Saklani, P; Skanes, A1

Reviews

2 review(s) available for uk 68798 and digoxin

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Novel anti-arrhythmic medications in the treatment of atrial fibrillation.
    Current cardiology reviews, 2012, Volume: 8, Issue:4

    Topics: Acetanilides; Amiodarone; Anisoles; Anti-Arrhythmia Agents; Atrial Fibrillation; Clinical Trials as Topic; Digoxin; Dronedarone; Forecasting; Heart Failure; Humans; Phenethylamines; Piperazines; Pyrrolidines; Ranolazine; Sulfonamides; Technology, Pharmaceutical; Ventricular Dysfunction, Left

2012

Trials

2 trial(s) available for uk 68798 and digoxin

ArticleYear
Effect of dofetilide on the pharmacokinetics of digoxin.
    The American journal of cardiology, 2001, Jan-15, Volume: 87, Issue:2

    Topics: Adult; Anti-Arrhythmia Agents; Digoxin; Double-Blind Method; Drug Interactions; Humans; Male; Phenethylamines; Sulfonamides

2001
Relationships between sinus rhythm, treatment, and survival in the Atrial Fibrillation Follow-Up Investigation of Rhythm Management (AFFIRM) Study.
    Circulation, 2004, Mar-30, Volume: 109, Issue:12

    Topics: Adrenergic beta-Antagonists; Amiodarone; Anti-Arrhythmia Agents; Anticoagulants; Atrial Fibrillation; Calcium Channel Blockers; Combined Modality Therapy; Comorbidity; Digoxin; Electric Countershock; Follow-Up Studies; Heart Rate; Humans; Models, Cardiovascular; Myocardial Contraction; Phenethylamines; Proportional Hazards Models; Retrospective Studies; Risk; Stroke; Sulfonamides; Survival Analysis; Treatment Failure; Treatment Outcome; Warfarin

2004

Other Studies

8 other study(ies) available for uk 68798 and digoxin

ArticleYear
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Dofetilide for atrial fibrillation.
    The New England journal of medicine, 2000, Jan-27, Volume: 342, Issue:4

    Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Atrial Fibrillation; Digoxin; Drug Interactions; Drug Therapy, Combination; Heart Failure; Humans; Phenethylamines; Sulfonamides

2000
The prognostic impact of shocks for clinical and induced arrhythmias on morbidity and mortality among patients with implantable cardioverter-defibrillators.
    Heart rhythm, 2010, Volume: 7, Issue:6

    Topics: Aged; Anti-Arrhythmia Agents; Cohort Studies; Confidence Intervals; Connecticut; Defibrillators, Implantable; Digoxin; Electrophysiology; Female; Heart Failure; Humans; Kaplan-Meier Estimate; Male; Multivariate Analysis; Phenethylamines; Prognosis; Proportional Hazards Models; Retrospective Studies; Risk Factors; Sulfonamides; Tachycardia, Ventricular; Treatment Outcome; Ventricular Fibrillation

2010