ucn-1028-c and nickel-chloride

ucn-1028-c has been researched along with nickel-chloride* in 1 studies

Other Studies

1 other study(ies) available for ucn-1028-c and nickel-chloride

Article	Year
High D-glucose stimulates the cell cycle from the G1 to the S and M phases, but has no competent effect on the G0 phase, in vascular smooth muscle cells. Biochemical and biophysical research communications, 1995, Jun-15, Volume: 211, Issue:2 The effects of high (28mM) D-glucose (HG) on the cell cycle progression were investigated in rat aorta vascular smooth muscle cells (VSMCs) in primary culture, using an immunocytochemical analysis of cell-cycle-specific nuclear antigens. HG had no effect on the cell cycle of the serum-deprived G0 cells, whereas platelet-derived growth factor (PDGF) stimulated the entry of the G0 cells to the G1 phase without a further progression to the S and M phases. HG, but neither mannitol nor L-glucose, stimulated the progression of the PDGF-pretreated G1 cells to the S and M phases, which was blocked by calphostin-C, a protein kinase C (PKC) blocker. HG did not affect the cytosolic Ca2+ concentration ([Ca2+]i). These data suggest that HG has no competent effect on the G0 cells and acts as a progression growth factor (to stimulate the cell cycle from the G1 to the S/M) in VSMCs through the mechanism, which may be insensitive to [Ca2+]i and mediated by PKC. Topics: Animals; Aorta; Becaplermin; Cell Cycle; Cells, Cultured; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; G1 Phase; Glucose; Humans; Ki-67 Antigen; Kinetics; Male; Mannitol; Mitosis; Muscle, Smooth, Vascular; Naphthalenes; Neoplasm Proteins; Nickel; Nuclear Proteins; Platelet-Derived Growth Factor; Polycyclic Compounds; Proliferating Cell Nuclear Antigen; Protein Kinase C; Proto-Oncogene Proteins c-sis; Rats; Rats, Wistar; Recombinant Proteins; Resting Phase, Cell Cycle; S Phase; Stereoisomerism; Time Factors	1995

Article

Year

High D-glucose stimulates the cell cycle from the G1 to the S and M phases, but has no competent effect on the G0 phase, in vascular smooth muscle cells.

Biochemical and biophysical research communications, 1995, Jun-15, Volume: 211, Issue:2

The effects of high (28mM) D-glucose (HG) on the cell cycle progression were investigated in rat aorta vascular smooth muscle cells (VSMCs) in primary culture, using an immunocytochemical analysis of cell-cycle-specific nuclear antigens. HG had no effect on the cell cycle of the serum-deprived G0 cells, whereas platelet-derived growth factor (PDGF) stimulated the entry of the G0 cells to the G1 phase without a further progression to the S and M phases. HG, but neither mannitol nor L-glucose, stimulated the progression of the PDGF-pretreated G1 cells to the S and M phases, which was blocked by calphostin-C, a protein kinase C (PKC) blocker. HG did not affect the cytosolic Ca2+ concentration ([Ca2+]i). These data suggest that HG has no competent effect on the G0 cells and acts as a progression growth factor (to stimulate the cell cycle from the G1 to the S/M) in VSMCs through the mechanism, which may be insensitive to [Ca2+]i and mediated by PKC.

Topics: Animals; Aorta; Becaplermin; Cell Cycle; Cells, Cultured; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; G1 Phase; Glucose; Humans; Ki-67 Antigen; Kinetics; Male; Mannitol; Mitosis; Muscle, Smooth, Vascular; Naphthalenes; Neoplasm Proteins; Nickel; Nuclear Proteins; Platelet-Derived Growth Factor; Polycyclic Compounds; Proliferating Cell Nuclear Antigen; Protein Kinase C; Proto-Oncogene Proteins c-sis; Rats; Rats, Wistar; Recombinant Proteins; Resting Phase, Cell Cycle; S Phase; Stereoisomerism; Time Factors

1995