uccf-029 and alpha-naphthoflavone

uccf-029 has been researched along with alpha-naphthoflavone* in 1 studies

Other Studies

1 other study(ies) available for uccf-029 and alpha-naphthoflavone

ArticleYear
Synthesis and structure-activity relationship studies of α-naphthoflavone derivatives as CYP1B1 inhibitors.
    European journal of medicinal chemistry, 2020, Feb-01, Volume: 187

    Cytochrome P450 1B1(CYP1B1) has been recognized as an important target for cancer prevention and drug resistance reversal. In order to obtain potent and selective CYP1B1 inhibitors, a series of forty-one α-naphthoflavone (ANF) derivatives were synthesized, characterized, and evaluated for CYP1B1, CYP1A1 and CYP1A2 inhibitory activities. A closure look into the structure-activity relationship for the inhibitory effects on CYP1B1 indicated that modification of the C ring of ANF would decrease the CYP1B1 inhibitory potency, while incorporation of substituent(s) into the different positions of the B ring yielded analogues with varying CYP1B1 inhibitory capacity. Among these derivatives, compounds 9e and 9j were identified as the most potent two selective CYP1B1 inhibitors with IC

    Topics: Benzoflavones; Cytochrome P-450 CYP1B1; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Molecular Docking Simulation; Molecular Structure; Recombinant Proteins; Structure-Activity Relationship

2020