ubiquinone-q3 and idebenone

ubiquinone-q3 has been researched along with idebenone* in 1 studies

Other Studies

1 other study(ies) available for ubiquinone-q3 and idebenone

Article	Year
Inhibition of glycerophosphate-dependent H2O2 generation in brown fat mitochondria by idebenone. Biochemical and biophysical research communications, 2006, Jan-06, Volume: 339, Issue:1 The established protective effect of coenzyme Q (CoQ) analogs is dependent on the location of reactive oxygen species (ROS) generation. One of these analogs--idebenone (hydroxydecyl-ubiquinone) is used as an antioxidative therapeutic drug. We tested its scavenging effect on the glycerophosphate (GP)-dependent ROS production as this enzyme was shown as a new site in the mitochondrial respiratory chain where ROS can be generated. We observed that idebenone inhibits both GP- and succinate-dependent ROS production. Idebenone and CoQ1 were found to be more efficient in the scavenging activity (IC50: 0.052 and 0.075 microM, respectively) than CoQ3 (IC50: 45.8 microM). Idebenone also inhibited ferricyanide (FeCN)-activated, GP-dependent ROS production. Our data thus extend previous findings on the scavenging effect of idebenone and show that it can also eliminate GP-dependent ROS generation. Topics: Adipose Tissue, Brown; Animals; Antioxidants; Benzoquinones; Cricetinae; Ferricyanides; Free Radical Scavengers; Glycerophosphates; Hydrogen Peroxide; In Vitro Techniques; Male; Mesocricetus; Mitochondria; Oxygen Consumption; Reactive Oxygen Species; Succinates; Ubiquinone	2006

Article

Year

Inhibition of glycerophosphate-dependent H2O2 generation in brown fat mitochondria by idebenone.

Biochemical and biophysical research communications, 2006, Jan-06, Volume: 339, Issue:1

The established protective effect of coenzyme Q (CoQ) analogs is dependent on the location of reactive oxygen species (ROS) generation. One of these analogs--idebenone (hydroxydecyl-ubiquinone) is used as an antioxidative therapeutic drug. We tested its scavenging effect on the glycerophosphate (GP)-dependent ROS production as this enzyme was shown as a new site in the mitochondrial respiratory chain where ROS can be generated. We observed that idebenone inhibits both GP- and succinate-dependent ROS production. Idebenone and CoQ1 were found to be more efficient in the scavenging activity (IC50: 0.052 and 0.075 microM, respectively) than CoQ3 (IC50: 45.8 microM). Idebenone also inhibited ferricyanide (FeCN)-activated, GP-dependent ROS production. Our data thus extend previous findings on the scavenging effect of idebenone and show that it can also eliminate GP-dependent ROS generation.

Topics: Adipose Tissue, Brown; Animals; Antioxidants; Benzoquinones; Cricetinae; Ferricyanides; Free Radical Scavengers; Glycerophosphates; Hydrogen Peroxide; In Vitro Techniques; Male; Mesocricetus; Mitochondria; Oxygen Consumption; Reactive Oxygen Species; Succinates; Ubiquinone

2006