ubiquinone and minaprine

ubiquinone has been researched along with minaprine* in 2 studies

Other Studies

2 other study(ies) available for ubiquinone and minaprine

ArticleYear
Nootropic candidates inhibit head-twitches induced by mescaline in mice.
    Japanese journal of pharmacology, 1992, Volume: 59, Issue:3

    The effects of various nootropic candidates on mescaline-induced head-twitches were studied in mice. The number of head-twitches induced by mescaline (100 mg/kg, s.c.) was significantly reduced by idebenone (32 and 100 mg/kg, i.p.), minaprine (0.32-10 mg/kg, p.o.) and nebracetam (100 mg/kg, p.o.). Cholinesterase inhibitors such as tetrahydroaminoacridine (1 and 10 mg/kg, p.o.), NIK-247 (10 and 18 mg/kg, p.o.) and physostigmine (0.32 mg/kg, i.p.) also suppressed the head-twitch response to mescaline. These results suggest that the direct or indirect cholinergic-activating effects of these drugs may be involved in inhibiting mescaline-induced head-twitches.

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Benzoquinones; Cholinesterase Inhibitors; Male; Mescaline; Mice; Mice, Inbred Strains; Psychotropic Drugs; Pyridazines; Pyrrolidinones; Ubiquinone

1992
Minaprine improves impairment of working memory induced by scopolamine and cerebral ischemia in rats.
    Psychopharmacology, 1990, Volume: 100, Issue:3

    Using a repeated acquisition procedure in a three-panel runway apparatus, the effects of minaprine on the impairment of working memory produced by scopolamine, ethylcholine aziridinium ion (AF64A) or cerebral ischemia were investigated in rats. Minaprine (3.2-32 mg/kg IP) as well as idebenone (10-100 mg/kg IP) and physostigmine (0.1-0.32 mg/kg IP) dose-dependently reduced the increase of errors (pushes made on the two incorrect panels located at each choice point) induced by 0.56 mg/kg IP scopolamine. Cerebral ischemia for 5 min caused a significant increase of errors in the runway task. Minaprine at 3.2 and 10 mg/kg administered IP immediately after blood recirculation and again 30 min before the runway test conducted 24 h after ischemia, significantly reduced increases in errors expected to occur after 5 min of ischemia. Physostigmine 0.1 mg/kg similarly attenuated the increase in errors in ischemic rats. However, minaprine at doses up to 32 mg/kg IP failed to reduce the increase of errors induced by AF64A 2.5 nmol injected into the dorsal hippocampus. These findings suggest that minaprine exerts an ameliorating effect on amnesia produced by scopolamine and cerebral ischemia, probably through mediation of its stimulant action on central cholinergic systems.

    Topics: Animals; Aziridines; Benzoquinones; Brain Ischemia; Choline; Hippocampus; Injections; Male; Memory; Physostigmine; Psychomotor Performance; Pyridazines; Quinones; Rats; Rats, Inbred Strains; Scopolamine; Ubiquinone

1990