ubiquinone and metadoxine

Hepatoprotective actions of metadoxina and ubiquinone have been studied in alcoholic rats by evaluating hepatic triglyceride accumulation and serum biochemical parameters of liver function. The two drug-treated groups displayed significantly lower triglyceride concentrations as compared to the ethanol-treated group. No significant differences were found among the two drug-treated and the control groups. Electron-microscopic abnormalities were found only in ethanol-treated rats. Serum biochemical parameters of liver function did not show any significant difference among all four groups. These results suggest a possible protective role of metadoxina and ubiquinone in ethanol-induced liver triglyceride accumulation.

Topics: Animals; Drug Combinations; Ethanol; Fatty Liver; Liver; Male; Osmolar Concentration; Pyridoxine; Pyrrolidonecarboxylic Acid; Rats; Time Factors; Triglycerides; Ubiquinone