ubiquinone and kaempferol

ubiquinone has been researched along with kaempferol* in 5 studies

Reviews

1 review(s) available for ubiquinone and kaempferol

ArticleYear
Kaempferol as a precursor for ubiquinone (coenzyme Q) biosynthesis: An atypical node between specialized metabolism and primary metabolism.
    Current opinion in plant biology, 2022, Volume: 66

    Ubiquinone (coenzyme Q) is a vital respiratory cofactor and liposoluble antioxidant. Studies have shown that plants derive approximately a quarter of 4-hydroxybenzoate, which serves as the direct ring precursor of ubiquinone, from the catabolism of kaempferol. Biochemical and genetic evidence suggests that the release of 4-hydroxybenzoate from kaempferol is catalyzed by heme-dependent peroxidases and that 3-O-glycosylations of kaempferol act as a negative regulator of this process. These findings not only represent an atypical instance of primary metabolite being derived from specialized metabolism but also raise the question as to whether ubiquinone contributes to the ROS scavenging and signaling functions already established for flavonols.

    Topics: Kaempferols; Plants; Ubiquinone

2022

Other Studies

4 other study(ies) available for ubiquinone and kaempferol

ArticleYear
Metabolism of the Flavonol Kaempferol in Kidney Cells Liberates the B-ring to Enter Coenzyme Q Biosynthesis.
    Molecules (Basel, Switzerland), 2020, Jun-27, Volume: 25, Issue:13

    Coenzyme Q (CoQ) is an essential component of the mitochondrial electron transport chain and an important antioxidant present in all cellular membranes. CoQ deficiencies are frequent in aging and in age-related diseases, and current treatments are limited to CoQ supplementation. Strategies that rely on CoQ supplementation suffer from poor uptake and trafficking of this very hydrophobic molecule. In a previous study, the dietary flavonol kaempferol was reported to serve as a CoQ ring precursor and to increase the CoQ content in kidney cells, but neither the part of the molecule entering CoQ biosynthesis nor the mechanism were described. In this study, kaempferol labeled specifically in the B-ring was isolated from

    Topics: Animals; Antioxidants; Ataxia; Epithelial Cells; Flavonols; Humans; Kaempferols; Kidney; Mice; Mitochondria; Mitochondrial Diseases; Mitochondrial Membranes; Muscle Weakness; Mutation; Ubiquinone

2020
The Peroxidative Cleavage of Kaempferol Contributes to the Biosynthesis of the Benzenoid Moiety of Ubiquinone in Plants.
    The Plant cell, 2018, Volume: 30, Issue:12

    Land plants possess the unique capacity to derive the benzenoid moiety of the vital respiratory cofactor, ubiquinone (coenzyme Q), from phenylpropanoid metabolism via β-oxidation of

    Topics: Arabidopsis; Gene Expression Regulation, Plant; Kaempferols; Parabens; Plants; Solanum lycopersicum; Ubiquinone

2018
Kaempferol increases levels of coenzyme Q in kidney cells and serves as a biosynthetic ring precursor.
    Free radical biology & medicine, 2017, Volume: 110

    Coenzyme Q (Q) is a lipid-soluble antioxidant essential in cellular physiology. Patients with Q deficiencies, with few exceptions, seldom respond to treatment. Current therapies rely on dietary supplementation with Q

    Topics: Animals; Antioxidants; Carbon Isotopes; Cell Line; Epithelial Cells; Fibroblasts; HEK293 Cells; Hep G2 Cells; HL-60 Cells; Humans; Isotope Labeling; Kaempferols; Kidney Tubules, Proximal; Mice; Mitochondria; Polyphenols; Saccharomyces cerevisiae; Sirtuin 3; Ubiquinone

2017
Complex I and cytochrome c are molecular targets of flavonoids that inhibit hydrogen peroxide production by mitochondria.
    Biochimica et biophysica acta, 2011, Volume: 1807, Issue:12

    Flavonoids can protect cells from different insults that lead to mitochondria-mediated cell death, and epidemiological data show that some of these compounds attenuate the progression of diseases associated with oxidative stress and mitochondrial dysfunction. In this work, a screening of 5 flavonoids representing major subclasses showed that they display different effects on H₂O₂ production by mitochondria isolated from rat brain and heart. Quercetin, kaempferol and epicatechin are potent inhibitors of H₂O₂ production by mitochondria from both tissues (IC₅₀ approximately 1-2 μM), even when H₂O₂ production rate was stimulated by the mitochondrial inhibitors rotenone and antimycin A. Although the rate of oxygen consumption was unaffected by concentrations up to 10 μM of these flavonoids, quercetin, kaempferol and apigenin inhibited complex I activity, while up to 100 μM epicatechin produced less than 20% inhibition. The extent of this inhibition was found to be dependent on the concentration of coenzyme Q in the medium, suggesting competition between the flavonoids and ubiquinone for close binding sites in the complex. In contrast, these flavonoids did not significantly inhibit the activity of complexes II and III, and did not affect the redox state of complex IV. However, we have found that epicatechin, quercetin and kaempferol are able to stoichiometrically reduce purified cytochrome c. Our results reveal that mitochondria are a plausible main target of flavonoids mediating, at least in part, their reported preventive actions against oxidative stress and mitochondrial dysfunction-associated pathologies.

    Topics: Animals; Antimycin A; Antioxidants; Apigenin; Brain; Catechin; Cytochromes c; Electron Transport Complex I; Flavonoids; Heart; Hydrogen Peroxide; Kaempferols; Mitochondria; Oxidants; Oxidation-Reduction; Oxygen Consumption; Quercetin; Rats; Rats, Wistar; Rotenone; Ubiquinone; Uncoupling Agents

2011