ubenimex has been researched along with thiorphan in 84 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 46 (54.76) | 18.7374 |
| 1990's | 29 (34.52) | 18.2507 |
| 2000's | 6 (7.14) | 29.6817 |
| 2010's | 2 (2.38) | 24.3611 |
| 2020's | 1 (1.19) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Bouboutou, R; Chaillet, P; Costentin, J; Coulaud, A; Devin, J; Fournié-Zaluski, MC; Roques, BP; Waksman, G | 1 |
| Benoliel, JJ; Bourgoin, S; Cesselin, F; Hamon, M; Legrand, JC; Mauborgne, A | 1 |
| Gintzler, AR; Sublette, E | 1 |
| Costentin, J; Cuber, JC; Doulut, S; Dubuc, I; Fulcrand, H; Kitabgi, P; Martinez, J; Nouel, D; Rodriguez, M | 1 |
| Bourgoin, S; Cesselin, F; Collin, E; Hamon, M; Mantelet, S | 1 |
| Bachoo, M; Polosa, C; Zhang, C | 1 |
| Baas, AA; Dzoljic, MM; Dzoljic, MR; Rupreht, J; Ukponmwan, OE; van den Berg, DJ | 1 |
| Chiyotani, A; Horii, S; Isono, K; Kanemura, T; Kobayashi, K; Sakai, N; Takeuchi, S; Takizawa, T; Tamaoki, J; Yamawaki, I | 1 |
| Ishikawa, K; Martinez, JL; Shibanoki, S; Weinberger, SB | 1 |
| Costentin, J; Dourmap, N; Michael-Titus, A; Schwartz, JC | 1 |
| Suh, HH; Tseng, LL | 2 |
| Herz, A; Parsons, CG | 1 |
| Giachetti, A; Giuliani, S; Maggi, CA; Meli, A; Patacchini, R; Santicioli, P | 1 |
| Benoliel, JJ; Berthier, JL; Bourgoin, S; Cesselin, F; Hamon, M; Hirsch, M; Mauborgne, A | 1 |
| Griesbacher, T; Hill, RG; Hughes, J; Leighton, GE | 1 |
| Castro, A; de Felipe, MC; Fuentes, JA; Jiménez, I | 1 |
| Caline, H; Costentin, J; Dourmap, N; Michael-Titus, A; Schwartz, JC | 1 |
| Livett, BG; Marley, PD; Mitchelhill, KI | 1 |
| Martinez, JL; Weinberger, SB | 1 |
| Aoki, K; Kajiwara, M; Oka, T | 2 |
| Basilico, L; Giagnoni, G; Gori, E; Mennuni, L; Parolaro, D; Pecora, N | 1 |
| Giros, B; Gros, C; Llorens-Cortes, C; Schwartz, JC | 1 |
| Borson, DB; Jacoby, DB; Nadel, JA; Tamaoki, J | 1 |
| Martinez, JL; Walker, RC; Weinberger, SB; Zafuto, CE | 1 |
| Gros, C; Llorens-Cortes, C; Schwartz, JC | 2 |
| Bourgoin, S; Cesselin, F; Dickenson, AH; Fournié-Zaluski, MC; Hamon, M; Le Bars, D; Roques, BP | 1 |
| Krielaart, MJ; Tijms, RP; van Amsterdam, JG; van Buuren, KJ; Zuiderveld, OP | 1 |
| Hill, RG; Hughes, J; Pittaway, KM | 1 |
| Kameyama, T; Katoh, A; Nabeshima, T | 1 |
| Fukaya, H; Furukawa, H; Hiramatsu, M; Kameyama, T; Nabeshima, T | 1 |
| Charpentier, B; Durieux, C; Pelaprat, D; Roques, BP | 1 |
| Artaud, F; Bouboutou, R; Bourgoin, S; Cesselin, F; Clot, AM; Fournie-Zaluski, MC; Hamon, M; Le Bars, D; Roques, BP | 1 |
| Kuraishi, Y; Satoh, M; Sugimoto, M; Takagi, H | 1 |
| Dickenson, AH; Fournie-Zaluski, MC; Roques, BP; Sullivan, AF | 1 |
| Han, JS; Jin, WQ; Zhou, ZF | 2 |
| Coquerel, A; Costentin, J; Dubuc, I; Kitabgi, P; Menard, JF | 1 |
| Anadón, A; Martinez-Larrañaga, MR | 1 |
| Bouboutou, R; Bourgoin, S; Cesselin, F; Devin, J; Fournie-Zaluski, MC; Hamon, M; Roques, B; Waksman, G | 1 |
| Han, JS; Yuan, H | 1 |
| Besselievre, R; Bouboutou, R; Devin, J; Fournie-Zaluski, MC; Roques, BP; Waksman, G | 1 |
| Chaillet, P; Costentin, J; Coulaud, A; Fournie-Zaluski, MC; Roques, BP; Zajac, JM | 1 |
| Chou, J; Costa, E; Del Rio, J; Tang, J; Yang, HY | 1 |
| Chaillet, P; Costentin, J; Coulaud, A; Fournié-Zaluski, MC; Gacel, G; Roques, BP | 1 |
| Brandt, U; Lentzen, H; Palenker, J | 1 |
| Lentzen, H; Palenker, J | 1 |
| Chaillet, P; Costentin, J; de la Baume, S; Marcais-Collado, H; Schwartz, JC; Yi, CC | 2 |
| Carenzi, A; Della Bella, D; Frigeni, V; Reggiani, A | 2 |
| Bouboutou, R; Chaillet, P; Cherot, P; Costentin, J; Coulaud, A; Fournie-Zaluski, MC; Roques, BP; Waksman, G | 1 |
| Checler, F; Emson, PC; Kitabgi, P; Vincent, JP | 1 |
| de la Baume, S; Giros, B; Gros, C; Schwartz, JC | 1 |
| Chaillet, P; Costentin, J; Lecomte, JM; Marçais, H; Natan, LB; Uchida, G | 1 |
| Llorens-Cortes, C; Schwartz, JC | 1 |
| Costa, E; Yang, HY; Zhang, AZ | 1 |
| Giuliani, S; Maggi, CA | 1 |
| Amidon, GL; Langguth, P; Nadai, T; Sakane, T; Sezaki, H; Taki, Y; Yamashita, S | 1 |
| Ogg, BG; Sangha, S; Stevens, CW | 1 |
| Hosoki, R; Otsuka, M; Saito, K; Seno, N; Suzuki, H; Yanagisawa, M | 1 |
| Devaux, B; Rose, C; Schwartz, JC; Silhouette, B; Vargas, F | 1 |
| Narkevich, VB; Nazarova, GA; Pozdnev, VF; Raevskiĭ, KS; Zolotov, NN | 1 |
| Kishioka, S; Masuda, Y; Miyamoto, Y; Ozaki, M; Yamamoto, H | 1 |
| Fuentes, JA; Iglesias, T; Otero, MJ | 1 |
| Alba, F; Fernández, R; Ferrer, JM | 1 |
| Belowski, D; Herman, ZS; Kowalski, J; Madej, A | 1 |
| Matsuda, T; Mori, M; Tsushima, H | 1 |
| Kovaleva, ES; Masler, EP; Wagner, RM | 1 |
| Ekström, G; Krondahl, E; Lennernäs, H; Orzechowski, A | 1 |
| Anderson, L; Bussler, B; Dufton, M; Martins, H | 1 |
| Fuentes, JA; Reche, I; Ruiz-Gayo, M | 1 |
| Brown, CH; Doi, N; Dutia, MB; Leng, G; Russell, JA | 1 |
| Bourgoin, S; Cesselin, F; Mauborgne, A; Poliénor, H; Roumy, M; Simonnet, G; Zajac, JM | 1 |
| Ino, K; Itakura, A; Ito, M; Kajiyama, H; Kikkawa, F; Mizutani, S; Nomura, S; Tsujimoto, M; Watanabe, Y | 1 |
| Blisnick, T; Desor, D; Dugave, C; Hermitte, V; Messaoudi, M; Rigault, AG; Rougeon, F; Rougeot, C | 1 |
| Dang, VC; Williams, JT | 1 |
| Axelband, F; Barros, NM; Carmona, AK; Dias, J; Ferrão, FM; Lara, LS; Miranda, F; Vieyra, A | 1 |
| Fournie-Zaluski, MC; Gore, C; Labuz, D; Machelska, H; Roques, BP; Schreiter, A; Stein, C | 1 |
| Bagley, EE; Gregoriou, GC; Patel, SD; Winters, BL | 1 |
84 other study(ies) available for ubenimex and thiorphan
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
New bidentates as full inhibitors of enkephalin-degrading enzymes: synthesis and analgesic properties.
Topics: Aminopeptidases; Analgesia; Animals; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Hydroxylamines; Leucine; Male; Mice; Neprilysin; Protease Inhibitors; Rabbits; Rats; Stereoisomerism; Thiorphan; Tiopronin | 1985 |
Opioid control of the in vitro release of cholecystokinin-like material from the rat substantia nigra.
Topics: Animals; Calcium; Cholecystokinin; Endorphins; Enkephalin, Methionine; In Vitro Techniques; Leucine; Ligands; Male; Potassium; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, Opioid; Substantia Nigra; Thiorphan | 1992 |
Stimulus frequency and intensity: critical determinants of opioid enhancement or inhibition of evoked methionine-enkephalin release.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Captopril; Cyclic AMP; Dipeptides; Electric Stimulation; Enkephalin, Methionine; Guinea Pigs; In Vitro Techniques; Leucine; Muscle, Smooth; Myenteric Plexus; Protease Inhibitors; Pyrrolidines; Thiorphan | 1992 |
Effects of thiorphan, bestatin and a novel metallopeptidase inhibitor JMV 390-1 on the recovery of neurotensin and neuromedin N released from mouse hypothalamus.
Topics: Amino Acid Sequence; Aminopeptidases; Animals; Hypothalamus; In Vitro Techniques; Leucine; Metalloendopeptidases; Mice; Molecular Sequence Data; Neprilysin; Neurotensin; Oligopeptides; Peptide Fragments; Potassium; Thiorphan | 1992 |
Feedback inhibition of met-enkephalin release from the rat spinal cord in vivo.
Topics: Animals; Calcitonin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Feedback; Indoles; Injections, Spinal; Leucine; Male; Morphinans; Naloxone; Naltrexone; Oligopeptides; Radioimmunoassay; Rats; Rats, Inbred Strains; Spinal Cord; Thiorphan | 1992 |
Naloxone-sensitive inhibition of nicotinic transmission in the superior cervical ganglion of the cat.
Topics: Action Potentials; Animals; Axons; Captopril; Cats; Electric Stimulation; Female; Ganglia, Sympathetic; Hexamethonium; Hexamethonium Compounds; Leucine; Male; Naloxone; Protease Inhibitors; Receptors, Nicotinic; Synapses; Synaptic Transmission; Thiorphan | 1991 |
Suppressive effects of enkephalins and REM sleep deprivation on seizures.
Topics: Animals; Cerebral Cortex; Dose-Response Relationship, Drug; Electroencephalography; Electroshock; Enkephalins; Glycopeptides; Leucine; Male; Mice; Mice, Inbred Strains; Neprilysin; Nitrous Oxide; Rats; Rats, Inbred Strains; Sleep Deprivation; Sleep, REM; Substance Withdrawal Syndrome; Thiorphan | 1991 |
Atrial natriuretic factor inhibits ciliary motility in cultured rabbit tracheal epithelium.
Topics: Animals; Atrial Natriuretic Factor; Captopril; Cells, Cultured; Cilia; Enzyme Inhibitors; Epithelium; Glycopeptides; Indomethacin; Kinetics; Leucine; Leupeptins; Male; Masoprocol; Methylene Blue; Movement; Piroxicam; Purinones; Rabbits; Thiorphan; Trachea | 1991 |
HPLC-ECD determination of the enzymatic hydrolysis of [leu]- and [met]enkephalin in rat plasma.
Topics: Acetylcholinesterase; Aminopeptidases; Animals; Captopril; CD13 Antigens; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Hydrolysis; In Vitro Techniques; Leucine; Male; Oligopeptides; Rats; Rats, Inbred Strains; Thiorphan; Tyrosine | 1990 |
Role of delta opioid receptors in the effects of inhibitors of enkephalin-degrading peptidases on the horizontal and vertical components of locomotion in mice.
Topics: Aminopeptidases; Animals; CD13 Antigens; Dipeptides; Drug Synergism; Enkephalin, Leucine; Enkephalins; Injections, Intravenous; Injections, Intraventricular; Leucine; Locomotion; Male; Mice; Naloxone; Neprilysin; Phenylcarbamates; Prodrugs; Receptors, Opioid; Receptors, Opioid, delta; Sulfhydryl Compounds; Thiorphan | 1990 |
Intrathecal administration of thiorphan, bestatin, desipramine and fluoxetine differentially potentiate the antinociceptive effects induced by beta-endorphin and morphine, administered intracerebroventricularly.
Topics: Analgesics; Animals; beta-Endorphin; Desipramine; Fluoxetine; Injections, Intraventricular; Injections, Spinal; Leucine; Male; Mice; Mice, Inbred ICR; Morphine; Reaction Time; Thiorphan | 1990 |
Peripheral opioid receptors mediating antinociception in inflammation. Evidence for activation by enkephalin-like opioid peptides after cold water swim stress.
Topics: Analgesia; Animals; Dioxolanes; Dipeptides; Enkephalins; Inflammation; Leucine; Male; Naloxone; Naltrexone; Neprilysin; Rats; Rats, Inbred Strains; Receptors, Opioid; Stress, Physiological; Swimming; Thiorphan | 1990 |
Further studies on the response of the guinea-pig isolated bronchus to endothelins and sarafotoxin S6b.
Topics: Animals; Aorta, Thoracic; Bronchi; Captopril; Endothelins; Epithelium; Guinea Pigs; In Vitro Techniques; Indomethacin; Leucine; Male; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Peptides; Protease Inhibitors; Rats; Rats, Inbred Strains; Thiorphan; Viper Venoms | 1990 |
Intrathecal administration of thiorphan and bestatin enhances the antinociception and release of Met-enkephalin induced by beta-endorphin intraventricularly in anesthetized rats.
Topics: Aminopeptidases; Anesthesia; Animals; beta-Endorphin; Enkephalin, Methionine; Injections, Intraventricular; Injections, Spinal; Leucine; Male; Nociceptors; Pain Measurement; Rats; Rats, Inbred Strains; Tail; Thiorphan | 1990 |
Enkephalinase is involved in the degradation of endogenous substance P released from slices of rat substantia nigra.
Topics: Animals; Captopril; Dipeptides; In Vitro Techniques; Leucine; Male; Metalloendopeptidases; Naloxone; Neprilysin; Oligopeptides; Peptidyl-Dipeptidase A; Potassium; Protease Inhibitors; Rats; Rats, Inbred Strains; Substance P; Substantia Nigra; Thiorphan; Tiopronin | 1987 |
Reduction of food intake by central administration of cholecystokinin octapeptide in the rat is dependent upon inhibition of brain peptidases.
Topics: Animals; Brain; Captopril; Ceruletide; Eating; Injections, Intraventricular; Leucine; Male; Protease Inhibitors; Rats; Rats, Inbred Strains; Sincalide; Thiorphan | 1989 |
Antidepressant action of imipramine and iprindole in mice is enhanced by inhibitors of enkephalin-degrading peptidases.
Topics: Animals; Antidepressive Agents; Imipramine; Indoles; Injections, Intraventricular; Iprindole; Leucine; Male; Mice; Mice, Inbred ICR; Motor Activity; Neprilysin; Thiorphan | 1989 |
Role of endogenous enkephalins in locomotion and nociception studied with peptidase inhibitors in two inbred strains of mice (C57BL/6J and DBA/2J).
Topics: Analgesics; Animals; Cerebral Ventricles; Enkephalins; Injections, Intraventricular; Leucine; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Motor Activity; Naloxone; Pain; Protease Inhibitors; Reference Values; Species Specificity; Thiorphan | 1989 |
Effects of opioid peptides containing the sequence of Met5-enkephalin or Leu5-enkephalin on nicotine-induced secretion from bovine adrenal chromaffin cells.
Topics: Adenosine Triphosphate; Adrenal Medulla; Amino Acid Sequence; Animals; Bacitracin; Cattle; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Epinephrine; Guinea Pigs; Leucine; Nicotine; Norepinephrine; Peptide Fragments; Phenanthrolines; Rabbits; Receptors, Opioid; Thiorphan; Tiopronin | 1986 |
Characterization of hydrolysis of [leu]enkephalin and D-ala2-[L-leu]enkephalin in rat plasma.
Topics: Aminopeptidases; Animals; CD13 Antigens; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Half-Life; Hydrolysis; Leucine; Male; Neprilysin; Peptidyl-Dipeptidase A; Rats; Rats, Inbred Strains; Thiorphan | 1988 |
The inactivation of [Met5]-enkephalin by bestatin-sensitive aminopeptidase, captopril-sensitive peptidyl dipeptidase A and thiorphan-sensitive endopeptidase-24.11 in mouse vas deferens.
Topics: Amino Acids, Sulfur; Aminopeptidases; Animals; Captopril; Dipeptides; Dose-Response Relationship, Drug; Endopeptidases; Enkephalin, Methionine; Glycopeptides; Guinea Pigs; Ileum; In Vitro Techniques; Leucine; Male; Mice; Mice, Inbred Strains; Muscle Contraction; Neprilysin; Peptidyl-Dipeptidase A; Phenylalanine; Thiorphan; Tiopronin; Vas Deferens | 1986 |
Binding studies of dermorphin and its L-form on rat brain opioid receptors.
Topics: Alanine; Animals; Binding, Competitive; Biological Assay; Brain; Captopril; Ileum; Leucine; Oligopeptides; Opioid Peptides; Rats; Receptors, Opioid; Stereoisomerism; Structure-Activity Relationship; Thiorphan; Tiopronin | 1987 |
[Opioid peptides: metabolism and receptors].
Topics: Animals; Brain; Cattle; Endopeptidases; Endorphins; Enkephalins; Humans; Leucine; Mice; Neprilysin; Pro-Opiomelanocortin; Protease Inhibitors; Protein Precursors; Receptors, Opioid; Thiorphan; Tiopronin | 1987 |
Influenza infection causes airway hyperresponsiveness by decreasing enkephalinase.
Topics: Animals; Captopril; Disease Models, Animal; Ferrets; In Vitro Techniques; Influenza A virus; Leucine; Leupeptins; Metalloendopeptidases; Muscle Contraction; Muscle, Smooth; Neprilysin; Orthomyxoviridae Infections; Thiorphan; Tiopronin; Trachea | 1988 |
Characterization of enkephalin degradation in rat plasma.
Topics: Aminopeptidases; Animals; Anti-Bacterial Agents; Captopril; Enkephalin, Leucine; Enkephalins; Kinetics; Leucine; Male; Rats; Rats, Inbred Strains; Thiorphan; Tiopronin | 1986 |
Evaluation of striatal enkephalin release in vivo from steady state levels and turnover rates of the tripeptide Tyr-Gly-Gly.
Topics: Animals; Anti-Bacterial Agents; Corpus Striatum; Enkephalins; In Vitro Techniques; Kinetics; Leucine; Male; Mice; Oligopeptides; Pentobarbital; Thiorphan; Tiopronin | 1986 |
Increase in met-enkephalin level and antinociceptive effects induced by kelatorphan in the rat spinal cord.
Topics: Analgesics; Animals; Dipeptides; Enkephalin, Methionine; In Vitro Techniques; Leucine; Neurons; Pain; Rats; Spinal Cord; Thiorphan; Tiopronin | 1986 |
Effect of inhibitors of enkephalin degradation in the isolated guinea-pig ileum.
Topics: Animals; Buffers; Dipeptides; Enkephalin, Methionine; Guinea Pigs; Ileum; In Vitro Techniques; Leucine; Male; Muscle Contraction; Muscle, Smooth; Neprilysin; Thiorphan | 1988 |
Antinociceptive action of cholecystokinin octapeptide (CCK 8) and related peptides in rats and mice: effects of naloxone and peptidase inhibitors.
Topics: Animals; Captopril; FMRFamide; Gastrins; Leucine; Male; Mice; Naloxone; Neuropeptides; Pain; Protease Inhibitors; Rats; Rats, Inbred Strains; Reaction Time; Sincalide; Tetragastrin; Thiorphan; Tiopronin | 1987 |
Inhibition of enkephalin degradation attenuated stress-induced motor suppression (conditioned suppression of motility).
Topics: Amino Acids, Sulfur; Aminopeptidases; Animals; Corpus Striatum; Dopamine; Enkephalin, Methionine; Enkephalins; Leucine; Male; Metalloendopeptidases; Mice; Motor Activity; Naloxone; Neprilysin; Pimozide; Stress, Physiological; Thiorphan; Tiopronin | 1988 |
Potentiation of phencyclidine-induced stereotyped behaviors in rats by thiorphan and bestatin.
Topics: Amino Acids, Sulfur; Animals; Drug Synergism; Leucine; Male; Naloxone; Phencyclidine; Rats; Rats, Inbred Strains; Stereotyped Behavior; Thiorphan; Time Factors; Tiopronin | 1986 |
Investigation on the metabolism of CCK8 analogues by rat brain slices.
Topics: Animals; Cerebral Cortex; Chloromercuribenzoates; Corpus Striatum; Hydrolysis; In Vitro Techniques; Leucine; p-Chloromercuribenzoic Acid; Peptide Fragments; Sincalide; Swine; Synaptic Membranes; Thiorphan; Tiopronin | 1986 |
Effects of kelatorphan and other peptidase inhibitors on the in vitro and in vivo release of methionine-enkephalin-like material from the rat spinal cord.
Topics: Animals; Dipeptides; Dose-Response Relationship, Drug; Enkephalin, Methionine; Leucine; Male; Potassium; Protease Inhibitors; Rats; Rats, Inbred Strains; Spinal Cord; Thiorphan; Tiopronin | 1986 |
Involvement of medullary opioid-peptidergic and spinal noradrenergic systems in the regulation of formalin-induced persistent pain.
Topics: Animals; Endorphins; Formaldehyde; Injections, Spinal; Leucine; Male; Medulla Oblongata; Naloxone; Norepinephrine; Pain; Rats; Rats, Inbred Strains; Spinal Cord; Thiorphan; Time Factors; Tiopronin | 1986 |
Prevention of degradation of endogenous enkephalins produces inhibition of nociceptive neurones in rat spinal cord.
Topics: Action Potentials; Animals; Dipeptides; Enkephalins; Leucine; Male; Naloxone; Nerve Fibers; Neural Inhibition; Neurons, Afferent; Pain; Protease Inhibitors; Rats; Rats, Inbred Strains; Spinal Cord; Thiorphan; Tiopronin | 1987 |
Electroacupuncture and morphine analgesia potentiated by bestatin and thiorphan administered to the nucleus accumbens of the rabbit.
Topics: Amino Acids, Sulfur; Analgesia; Animals; Dose-Response Relationship, Drug; Enkephalin, Methionine; Immune Sera; Leucine; Male; Microinjections; Morphine; Naloxone; Nucleus Accumbens; Rabbits; Septal Nuclei; Thiorphan; Time Factors; Tiopronin; Transcutaneous Electric Nerve Stimulation | 1986 |
Naloxone-insensitive potentiation of neurotensin hypothermic effect by the enkephalinase inhibitor thiorphan.
Topics: Amino Acids, Sulfur; Animals; Body Temperature; Captopril; Drug Synergism; Endopeptidases; Injections, Intraventricular; Leucine; Male; Mice; Naloxone; Neprilysin; Neurotensin; Thiorphan; Tiopronin | 1986 |
An inhibitory action of tetracyclines on guinea-pig myenteric plexus.
Topics: Animals; Captopril; Drug Interactions; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Leucine; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naloxone; Protease Inhibitors; Tetracyclines; Thiorphan; Tiopronin | 1987 |
In vitro and in vivo effects of kelatorphan on enkephalin metabolism in rodent brain.
Topics: Aminopeptidases; Animals; Brain; Brain Chemistry; Corpus Striatum; Dipeptides; Enkephalin, Methionine; Enkephalins; Hydrolysis; In Vitro Techniques; Leucine; Mice; Protease Inhibitors; Rats; Thiorphan; Tiopronin | 1985 |
[Electroacupuncture accelerates the biogenesis of central enkephalins in the rat].
Topics: Acupuncture Therapy; Aminopeptidases; Animals; Brain; Electric Stimulation Therapy; Enkephalin, Leucine; Enkephalin, Methionine; Female; Leucine; Male; Phenylalanine; Radioimmunoassay; Rats; Thiorphan; Tiopronin; Transcutaneous Electric Nerve Stimulation | 1985 |
Binding of the bidentate inhibitor [3H]HACBO-Gly to the rat brain neutral endopeptidase "enkephalinase".
Topics: Animals; Brain; Captopril; Cell Membrane; Corpus Striatum; Glycine; Hydroxylamines; Leucine; Male; Neprilysin; Protease Inhibitors; Rats; Rats, Inbred Strains; Substantia Nigra; Thiorphan; Tiopronin; Tissue Distribution | 1985 |
Study of endogenous Tyr-Gly-Gly, a putative enkephalin metabolite, in mouse brain: validation of a radioimmunoassay, localisation and effects of peptidase inhibitors.
Topics: Animals; Brain; Captopril; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Leucine; Male; Mice; Microwaves; Nalorphine; Neprilysin; Oligopeptides; Protease Inhibitors; Radioimmunoassay; Thiorphan; Tiopronin | 1985 |
[Inhibition of enkephalins degradation in the nucleus accumbens leads to potentiation of acupuncture and morphine analgesia].
Topics: Acupuncture Therapy; Aminopeptidases; Analgesia; Animals; Electric Stimulation Therapy; Endopeptidases; Enkephalin, Leucine; Enkephalin, Methionine; Leucine; Male; Morphine; Neprilysin; Nucleus Accumbens; Protease Inhibitors; Rabbits; Septal Nuclei; Thiorphan; Tiopronin; Transcutaneous Electric Nerve Stimulation | 1985 |
The mu rather than the delta subtype of opioid receptors appears to be involved in enkephalin-induced analgesia.
Topics: Analgesics; Animals; Enkephalin, Leucine; Enkephalins; Guinea Pigs; In Vitro Techniques; Leucine; Male; Mice; Morphine; Muscle Contraction; Muscle, Smooth; Nalorphine; Naloxone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Thiorphan; Tiopronin | 1984 |
The role of bestatin-sensitive aminopeptidase, angiotensin converting enzyme and thiorphan-sensitive "enkephalinase" in the potency of enkephalins in the guinea-pig ileum.
Topics: Amino Acids, Sulfur; Aminopeptidases; Animals; Anti-Bacterial Agents; Captopril; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Endopeptidases; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Leucine; Male; Neprilysin; Oligopeptides; Peptides; Peptidyl-Dipeptidase A; Thiorphan; Tiopronin | 1984 |
Action of peptidase inhibitors on methionine5-enkephalin-arginine6-phenylalanine7 (YGGFMRF) and methionine5-enkephalin (YGGFM) metabolism and on electroacupuncture antinociception.
Topics: Acupuncture Therapy; Analgesia; Animals; Captopril; Electronarcosis; Enkephalin, Methionine; Leucine; Male; Perfusion; Protease Inhibitors; Rats; Rats, Inbred Strains; Spinal Cord; Substance P; Thiorphan; Tiopronin | 1984 |
Pain control by endogenous enkephalins is mediated by mu opioid receptors.
Topics: Amino Acids, Sulfur; Analgesia; Animals; Enkephalin, Methionine; Enkephalins; Leucine; Male; Mice; Pain; Protease Inhibitors; Receptors, Opioid; Receptors, Opioid, mu; Thiorphan; Tiopronin | 1983 |
Enkephalin degradation by enkephalinergic neuroblastoma cells. Involvement of angiotensin-converting-enzyme.
Topics: Aminopeptidases; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Cell Line; Cell Membrane; Cells, Cultured; Enkephalin, Leucine; Hydrolysis; Leucine; Mice; Neuroblastoma; Peptidyl-Dipeptidase A; Thiorphan; Tiopronin | 1984 |
Localization of the thiorphan-sensitive endopeptidase, termed enkephalinase A, on glial cells.
Topics: Aminopeptidases; Animals; Astrocytes; Brain; Cell Membrane; Cells, Cultured; Endopeptidases; Enkephalin, Leucine; Kinetics; Leucine; Neprilysin; Protease Inhibitors; Rats; Thiorphan; Tiopronin | 1983 |
Peptidases involved in the inactivation of exogenous and endogenous enkephalins.
Topics: Aminopeptidases; Animals; Brain; Endopeptidases; Enkephalins; Leucine; Mice; Neprilysin; Nociceptors; Rats; Thiorphan; Tiopronin | 1983 |
Effect of inhibition of neuropeptidases on the pain threshold of mice and rats.
Topics: Aminopeptidases; Animals; Endopeptidases; Enkephalin, Leucine; Leucine; Male; Mice; Neprilysin; Pain; Protease Inhibitors; Rats; Rats, Inbred Strains; Sensory Thresholds; Species Specificity; Thiorphan; Tiopronin | 1983 |
Analgesic effects of kelatorphan, a new highly potent inhibitor of multiple enkephalin degrading enzymes.
Topics: Aminopeptidases; Analgesics; Animals; Brain; Dipeptides; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Endopeptidases; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Kidney; Leucine; Neprilysin; Protease Inhibitors; Rabbits; Rats; Reaction Time; Thiorphan; Tiopronin | 1984 |
Inactivation of neurotensin by rat brain synaptic membranes. Cleavage at the Pro10-Tyr11 bond by endopeptidase 24.11 (enkephalinase) and a peptidase different from proline-endopeptidase.
Topics: Animals; Captopril; Dipeptides; Endopeptidases; Hydrolysis; Leucine; Neprilysin; Neurotensin; Peptide Fragments; Peptide Hydrolases; Proline; Prolyl Oligopeptidases; Rats; Serine Endopeptidases; Synaptic Membranes; Thiorphan; Tiopronin; Tyrosine | 1984 |
Effect of bestatin and thiorphan on [Met5]enkephalin-Arg6-Phe7-induced analgesia.
Topics: Amino Acids, Sulfur; Aminopeptidases; Analgesia; Animals; Enkephalin, Methionine; Leucine; Male; Neprilysin; Protease Inhibitors; Rats; Rats, Inbred Strains; Thiorphan; Tiopronin | 1984 |
[Inhibition of the evoked liberation of (Met5)enkephalin from slices of globus pallidus in the presence of thiorphan and bestatin].
Topics: Amino Acids, Sulfur; Aminopeptidases; Animals; Electric Stimulation; Enkephalin, Methionine; Globus Pallidus; In Vitro Techniques; Leucine; Potassium Chloride; Protease Inhibitors; Rats; Thiorphan; Tiopronin | 1983 |
Inhibition of enkephalin metabolism by, and antinociceptive activity of, bestatin, an aminopeptidase inhibitor.
Topics: Aminopeptidases; Analgesics; Animals; Brain; Drug Synergism; Enkephalins; Hydrolysis; In Vitro Techniques; Leucine; Male; Mice; Mice, Inbred Strains; Puromycin; Rats; Rats, Inbred Strains; Thiorphan; Tiopronin | 1983 |
Involvement of endogenous enkephalins in the mouse 'behavioral despair' test.
Topics: Aminopeptidases; Animals; Behavior, Animal; Enkephalin, Methionine; Enkephalins; Leucine; Male; Mice; Motor Activity; Naloxone; Protease Inhibitors; Thiorphan; Tiopronin | 1984 |
Changes in turnover of cerebral monoamines following inhibition of enkephalin metabolism by thiorphan and bestatin.
Topics: alpha-Methyltyrosine; Amino Acids, Sulfur; Aminopeptidases; Animals; Biogenic Amines; Brain; Enkephalins; Leucine; Male; Methyltyrosines; Mice; Naloxone; Protease Inhibitors; Thiorphan; Tiopronin | 1984 |
Nociception, enkephalin content and dipeptidyl carboxypeptidase activity in brain of mice treated with exopeptidase inhibitors.
Topics: Animals; Brain; Corpus Striatum; Endopeptidases; Enkephalin, Methionine; Enkephalins; Exopeptidases; Female; Leucine; Mice; Neprilysin; Nociceptors; Protease Inhibitors; Thiorphan; Tiopronin | 1982 |
A thiorphan-sensitive mechanism regulates the action of both exogenous and endogenous calcitonin gene-related peptide (CGRP) in the guinea-pig ureter.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Captopril; Electric Stimulation; Endothelins; Guinea Pigs; Humans; Leucine; Male; Muscle Contraction; Muscle, Smooth; Thiorphan; Ureter | 1994 |
Gastrointestinal absorption of peptide drug: quantitative evaluation of the degradation and the permeation of metkephamid in rat small intestine.
Topics: Amino Acid Sequence; Aminopeptidases; Animals; Biological Availability; Enkephalin, Methionine; Intestinal Absorption; Intestine, Small; Leucine; Male; Molecular Sequence Data; Puromycin; Rats; Rats, Wistar; Thiorphan | 1995 |
Analgesia produced by immobilization stress and an enkephalinase inhibitor in amphibians.
Topics: Acetates; Acetic Acid; Analgesia; Animals; Immobilization; Injections, Spinal; Leucine; Naloxone; Neprilysin; Pain Measurement; Protease Inhibitors; Rana pipiens; Stress, Psychological; Thiorphan | 1995 |
Potentiating effect of peptidase inhibitors on a C fiber-evoked response in the isolated spinal cord preparation of the neonatal rat.
Topics: Animals; Animals, Newborn; Captopril; Drug Synergism; Evoked Potentials; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Guanidines; Hydroxamic Acids; In Vitro Techniques; Kinetics; Leucine; Nerve Fibers; Neurokinin A; Protease Inhibitors; Rats; Rats, Wistar; Spinal Cord; Spinal Nerve Roots; Substance P; Tetrodotoxin; Thiorphan | 1993 |
Characterization of a serine peptidase responsible for the inactivation of endogenous cholecystokinin in human brain.
Topics: Amino Acid Sequence; Aminopeptidases; Animals; Cerebral Cortex; Humans; Isoflurophate; Leucine; Molecular Sequence Data; Neprilysin; Nerve Tissue Proteins; Rats; Serine Endopeptidases; Serpins; Sincalide; Thiorphan | 1995 |
[Neuroleptic catalepsy in rats is accompanied by activation of brain prolyl endopeptidase and is eliminated by inhibitors of this enzyme].
Topics: Animals; Brain; Catalepsy; Enzyme Activation; Haloperidol; Leucine; Prolyl Oligopeptidases; Rats; Serine Endopeptidases; Serine Proteinase Inhibitors; Thiorphan; Trifluoperazine | 1994 |
Effect of some peptidase inhibitors on exogenous and endogenous opioid actions in guinea-pig ileum.
Topics: Aminopeptidases; Animals; Bacitracin; Captopril; Dose-Response Relationship, Drug; Electric Stimulation; Endorphins; Enkephalin, Methionine; Glycopeptides; Guinea Pigs; Ileum; Leucine; Male; Morphine; Muscle Contraction; Muscle, Smooth; Protease Inhibitors; Thiorphan | 1994 |
Hypoalgesic action of bestatin analogues that inhibit central aminopeptidases, but not neutral endopeptidase.
Topics: Aminopeptidases; Analgesics; Animals; Cycloleucine; Drug Interactions; Enkephalin, Methionine; Injections, Intraventricular; Leucine; Male; Mice; Naloxone; Neprilysin; Pain Measurement; Protease Inhibitors; Thiorphan | 1993 |
Peptidase inhibitors potentiate the effects of neurotensin and neuromedin N on self-stimulation of the medial prefrontal cortex.
Topics: Animals; Conditioning, Operant; Leucine; Male; Microinjections; Neurotensin; Peptide Fragments; Prefrontal Cortex; Protease Inhibitors; Rats; Rats, Wistar; Self Stimulation; Thiorphan | 1996 |
Antitumor activity of bestatin and thiorphan in mice.
Topics: Animals; Antineoplastic Agents; Drug Synergism; Female; Killer Cells, Natural; Leucine; Macrophages; Male; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Naloxone; Protease Inhibitors; Thiorphan | 1995 |
Peptidase inhibitor-induced antidiuresis mediated through angiotensin and opioid receptors in the rat hypothalamus.
Topics: Aminopeptidases; Angiotensin II; Animals; Carboxypeptidases; Diuresis; Hemodynamics; Hypothalamus; Leucine; Male; Naloxone; Protease Inhibitors; Rats; Rats, Wistar; Receptors, Angiotensin; Receptors, Opioid; Thiorphan | 1996 |
In vitro metabolism of an insect neuropeptide by neural membrane preparations from Lymantria dispar.
Topics: Amino Acid Sequence; Aminopeptidases; Animals; Anti-Bacterial Agents; Edetic Acid; Endopeptidases; Ganglia, Invertebrate; Glycopeptides; In Vitro Techniques; Insect Hormones; Lepidoptera; Leucine; Molecular Sequence Data; Peptides; Protease Inhibitors; Thiorphan | 1996 |
Rat jejunal permeability and metabolism of mu-selective tetrapeptides in gastrointestinal fluids from humans and rats.
Topics: Amidines; Animals; Drug Stability; Enkephalins; Gastric Juice; Humans; Intestinal Absorption; Jejunum; Leucine; Male; Microvilli; Oligopeptides; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Sulfones; Thiorphan | 1997 |
Enkephalin-processing oligopeptidases in cobra venom: inhibition by thiorphan and bestatin reveals co-operative actions.
Topics: Aminopeptidases; Animals; Drug Synergism; Elapid Venoms; Elapidae; Enkephalins; In Vitro Techniques; Leucine; Peptide Hydrolases; Protease Inhibitors; Substrate Specificity; Thiorphan | 1998 |
Inhibition of opioid-degrading enzymes potentiates delta9-tetrahydrocannabinol-induced antinociception in mice.
Topics: Aminopeptidases; Animals; Dronabinol; Injections, Intraventricular; Leucine; Male; Mice; Narcotic Antagonists; Neprilysin; Pain Threshold; Protease Inhibitors; Thiorphan | 1998 |
Inhibitory actions of nociceptin (orphanin FQ) on rat supraoptic nucleus oxytocin and vasopressin neurones in vitro.
Topics: Animals; Evoked Potentials; Female; In Vitro Techniques; Leucine; Membrane Potentials; Naloxone; Narcotic Antagonists; Neurons; Nociceptin; Opioid Peptides; Oxytocin; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Supraoptic Nucleus; Thiorphan; Vasopressins | 1998 |
The neuropeptide FF analogue, 1DMe, acts as a functional opioid autoreceptor antagonist in the rat spinal cord.
Topics: Animals; Autoreceptors; Dose-Response Relationship, Drug; Enkephalin, Methionine; In Vitro Techniques; Leucine; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Potassium; Rats; Rats, Sprague-Dawley; Spinal Cord; Thiorphan | 2001 |
Possible involvement of placental peptidases that degrade gonadotropin-releasing hormone (GnRH) in the dynamic pattern of placental hCG secretion via GnRH degradation.
Topics: Adult; Antibodies, Blocking; Chorionic Villi; Chromatography, High Pressure Liquid; Edetic Acid; Female; Glycopeptides; Gonadotropin-Releasing Hormone; Humans; Intracellular Membranes; Labor, Obstetric; Leucine; Leucyl Aminopeptidase; Neprilysin; Organ Culture Techniques; Phenanthrolines; Pregnancy; Pregnancy Trimester, First; Protease Inhibitors; Thiorphan | 2002 |
Sialorphin, a natural inhibitor of rat membrane-bound neutral endopeptidase that displays analgesic activity.
Topics: Amino Acid Sequence; Analgesics; Animals; Enkephalin, Methionine; Formaldehyde; Glycopeptides; Kidney; Leucine; Male; Membrane Proteins; Molecular Sequence Data; Naltrexone; Neprilysin; Pain; Pain Measurement; Prostate; Protease Inhibitors; Protein Precursors; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Salivary Proteins and Peptides; Spinal Cord; Submandibular Gland; Substance P; Thiorphan; Wounds and Injuries | 2003 |
Chronic morphine treatment reduces recovery from opioid desensitization.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Cocaine; Drug Tolerance; Enkephalin, Methionine; Leucine; Locus Coeruleus; Male; Monensin; Morphine; Morphine Dependence; Morphine Derivatives; Norepinephrine; Phosphorylation; Prazosin; Protein Kinase C; Protein Processing, Post-Translational; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Opioid, mu; Staurosporine; Thiorphan; Yohimbine | 2004 |
A scrutiny of the biochemical pathways from Ang II to Ang-(3-4) in renal basolateral membranes.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Basement Membrane; Chromatography, High Pressure Liquid; Hydrolysis; Kidney; Leucine; Lysine Carboxypeptidase; Peptidyl-Dipeptidase A; Thiorphan | 2009 |
Pain inhibition by blocking leukocytic and neuronal opioid peptidases in peripheral inflamed tissue.
Topics: Alanine; Amino Acid Sequence; Animals; Antibodies; CD13 Antigens; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enzyme Inhibitors; Flow Cytometry; Hindlimb; Inflammation; Leucine; Leukocytes; Male; Narcotic Antagonists; Neprilysin; Neurons; Opioid Peptides; Pain; Pain Threshold; Phosphinic Acids; Rats; Rats, Wistar; Receptors, Opioid; Thiorphan | 2012 |
[Just Checking].
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; CD13 Antigens; Endorphins; Humans; Inflammation; Leucine; Peptide Hydrolases; Protease Inhibitors; Thiorphan | 2013 |
Neprilysin Controls the Synaptic Activity of Neuropeptides in the Intercalated Cells of the Amygdala.
Topics: Amygdala; Animals; Captopril; Electrical Synapses; Enkephalins; Glutamic Acid; Leucine; Male; Neprilysin; Protease Inhibitors; Proteolysis; Rats; Rats, Sprague-Dawley; Signal Transduction; Thiorphan | 2020 |