| Protein | Taxonomy | u 86983 (IC50) | 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one (IC50) |
|---|
| Chain A, Proto-oncogene serine/threonine-protein kinase Pim-1 | Homo sapiens (human) | | 4 |
| Chain A, Proto-oncogene serine/threonine-protein kinase Pim-1 | Homo sapiens (human) | | 4 |
| Chain A, Methyltransferase Wbdd | Escherichia coli | | 68 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | Homo sapiens (human) | | 1.6413 |
| Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta | Homo sapiens (human) | | 1.4218 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | | 1.002 |
| cGMP-specific 3',5'-cyclic phosphodiesterase | Homo sapiens (human) | | 9.614 |
| Cytochrome P450 1A2 | Homo sapiens (human) | | 1 |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | | 1.6 |
| Serine/threonine-protein kinase pim-1 | Homo sapiens (human) | | 3.364 |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | | 1.6 |
| Casein kinase II subunit alpha' | Homo sapiens (human) | | 6.9 |
| Phosphatidylinositol 3-kinase regulatory subunit alpha | Homo sapiens (human) | | 3.1638 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | | 2.796 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | | 1.002 |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | | 2.3 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | Bos taurus (cattle) | | 3.7533 |
| Type-1 angiotensin II receptor | Oryctolagus cuniculus (rabbit) | | 0.5 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | Homo sapiens (human) | | 1.4593 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | Mus musculus (house mouse) | | 0.5 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | Homo sapiens (human) | | 1.2922 |
| Serine/threonine-protein kinase mTOR | Homo sapiens (human) | | 4.1638 |
| Serine/threonine-protein kinase mTOR | Rattus norvegicus (Norway rat) | | 2.5 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | Homo sapiens (human) | | 2.4845 |
| Glycogen synthase kinase-3 beta | Homo sapiens (human) | | 8.1 |
| Serine/threonine-protein kinase PLK1 | Homo sapiens (human) | | 2.05 |
| Casein kinase II subunit beta | Homo sapiens (human) | | 6.9 |
| Casein kinase II subunit alpha | Homo sapiens (human) | | 6.9 |
| DNA-dependent protein kinase catalytic subunit | Homo sapiens (human) | | 1.32 |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | | 1.6 |
| Serine/threonine-protein kinase pim-3 | Homo sapiens (human) | | 1.4 |
| Phosphoinositide 3-kinase regulatory subunit 5 | Homo sapiens (human) | | 1.72 |
| Serine/threonine-protein kinase PLK3 | Homo sapiens (human) | | 3 |
2 other study(ies) available for u 86983 and 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one
| Article | Year |
|---|
PDE2 inhibition by the PI3 kinase inhibitor LY294002 and analogues.Bioorganic & medicinal chemistry letters, 2004, Jun-07, Volume: 14, Issue:11
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Blood Platelets; Chromones; Cyclic Nucleotide Phosphodiesterases, Type 2; Cyclic Nucleotide Phosphodiesterases, Type 3; Dose-Response Relationship, Drug; Humans; Morpholines; Phosphodiesterase Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Phosphoric Diester Hydrolases; Structure-Activity Relationship | 2004 |
Analysis of anti-PDE3 activity of 2-morpholinochromone derivatives reveals multiple mechanisms of anti-platelet activity.Bioorganic & medicinal chemistry letters, 2006, Feb-15, Volume: 16, Issue:4
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Chromones; Cyclic Nucleotide Phosphodiesterases, Type 3; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Humans; Molecular Structure; Morpholines; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Thrombin; Structure-Activity Relationship | 2006 |