u-75412e and diphenyleneiodonium

u-75412e has been researched along with diphenyleneiodonium* in 2 studies

Other Studies

2 other study(ies) available for u-75412e and diphenyleneiodonium

Article	Year
Suppressive effects of a novel antioxidant compound on human T cell functions in vitro. Agents and actions, 1993, Volume: 39 Spec No The use of antioxidant compounds with differing modes of action has clearly demonstrated involvement of oxidative processes in the activation of T lymphocytes. In this paper, we show that a novel antioxidant (lazaroid U75412E, a free radical scavenger) suppressed mitogen-induced T cell proliferation in vitro. Similar results were obtained with diphenylene iodonium (DPI), a known inhibitor of NADPH oxidase. The lazaroid was further shown to inhibit IL 2 production but to be less potent in suppressing IL 2 receptor expression. Thus, scavenger-type antioxidants act on T cells primarily by blocking a signal necessary for the induction of IL 2 synthesis such as the activation of NF kappa B. Furthermore, the potent inhibition of lymphocyte responses caused by the specific enzyme inhibitor DPI provides direct proof of the source of the oxidants involved in these processes. Topics: Antioxidants; Centrifugation, Density Gradient; Free Radical Scavengers; Humans; Interleukin-2; Lymphocyte Activation; Onium Compounds; Receptors, Interleukin-2; Steroids; T-Lymphocytes; Tetradecanoylphorbol Acetate	1993
Antioxidant drugs as modulators of lymphocyte activation in vitro. Molecular aspects of medicine, 1991, Volume: 12, Issue:2 Topics: Antioxidants; Free Radicals; Humans; In Vitro Techniques; Lymphocyte Activation; NADH, NADPH Oxidoreductases; NADPH Oxidases; Onium Compounds; Oxygen; Receptors, Interleukin-2; Steroids; T-Lymphocytes	1991

Article

Year

Suppressive effects of a novel antioxidant compound on human T cell functions in vitro.

Agents and actions, 1993, Volume: 39 Spec No

The use of antioxidant compounds with differing modes of action has clearly demonstrated involvement of oxidative processes in the activation of T lymphocytes. In this paper, we show that a novel antioxidant (lazaroid U75412E, a free radical scavenger) suppressed mitogen-induced T cell proliferation in vitro. Similar results were obtained with diphenylene iodonium (DPI), a known inhibitor of NADPH oxidase. The lazaroid was further shown to inhibit IL 2 production but to be less potent in suppressing IL 2 receptor expression. Thus, scavenger-type antioxidants act on T cells primarily by blocking a signal necessary for the induction of IL 2 synthesis such as the activation of NF kappa B. Furthermore, the potent inhibition of lymphocyte responses caused by the specific enzyme inhibitor DPI provides direct proof of the source of the oxidants involved in these processes.

Topics: Antioxidants; Centrifugation, Density Gradient; Free Radical Scavengers; Humans; Interleukin-2; Lymphocyte Activation; Onium Compounds; Receptors, Interleukin-2; Steroids; T-Lymphocytes; Tetradecanoylphorbol Acetate

1993

Antioxidant drugs as modulators of lymphocyte activation in vitro.

Molecular aspects of medicine, 1991, Volume: 12, Issue:2

Topics: Antioxidants; Free Radicals; Humans; In Vitro Techniques; Lymphocyte Activation; NADH, NADPH Oxidoreductases; NADPH Oxidases; Onium Compounds; Oxygen; Receptors, Interleukin-2; Steroids; T-Lymphocytes

1991