Page last updated: 2024-09-02

u 74500a and u 74006f

u 74500a has been researched along with u 74006f in 18 studies

Compound Research Comparison

Studies
(u 74500a)
Trials
(u 74500a)
Recent Studies (post-2010)
(u 74500a)
Studies
(u 74006f)
Trials
(u 74006f)
Recent Studies (post-2010) (u 74006f)
81023624911

Protein Interaction Comparison

ProteinTaxonomyu 74500a (IC50)u 74006f (IC50)
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.718
Tyrosine-protein kinase FynHomo sapiens (human)1.116
Alpha-2C adrenergic receptorHomo sapiens (human)7.898
5-hydroxytryptamine receptor 2AHomo sapiens (human)2.002
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.718
Mitogen-activated protein kinase 14Homo sapiens (human)7.406

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19902 (11.11)18.7374
1990's16 (88.89)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hall, ED1
Bonin, PD; Singh, JP1
Audus, KL; Braughler, JM; Guillot, FL1
Choi, DW; Hartley, DM; Monyer, H1
Braughler, JM; Pregenzer, JF1
Braughler, JM; Chase, RL; Duncan, LA; Jacobsen, EJ; McCall, JM; Pregenzer, JF1
Audus, KL; Cavitt, J; Shi, F1
Buxser, SE; Decker, DE; Goodman, TG; Peterson, T; Vroegop, SM1
Hall, ED; McCall, JM1
Cazers, AR; Epps, DE; Horan, KL; Lutzke, BS; McCall, JM1
Davis, JW; Petry, TW1
Burton, KP1
Hall, ED; McCall, JM; Means, ED1
Pearson, PG; Petry, TW; Ryan, TP; Steenwyk, RC1
Petry, TW; Ryan, TP1
Althaus, JS; Fici, GJ; VonVoigtlander, PF1
Ishizaki, N; Kobayashi, Y; Nemoto, A; Starzl, TE; Subbotin, V; Todo, S; Zhang, S; Zhu, Y1
Kawachi, Y; Masuda, M; Morita, S; Nishida, T; Tominaga, R; Yasui, H1

Reviews

2 review(s) available for u 74500a and u 74006f

ArticleYear
Novel inhibitors of iron-dependent lipid peroxidation for neurodegenerative disorders.
    Annals of neurology, 1992, Volume: 32 Suppl

    Topics: Animals; Antioxidants; Brain Diseases; Humans; Iron; Lipid Peroxidation; Nerve Degeneration; Pregnatrienes

1992
Therapeutic potential of the lazaroids (21-aminosteroids) in acute central nervous system trauma, ischemia and subarachnoid hemorrhage.
    Advances in pharmacology (San Diego, Calif.), 1994, Volume: 28

    Topics: Animals; Antioxidants; Brain; Brain Injuries; Brain Ischemia; Humans; Lipid Peroxidation; Lipid Peroxides; Methylprednisolone; Pregnatrienes; Spinal Cord Injuries; Subarachnoid Hemorrhage

1994

Other Studies

16 other study(ies) available for u 74500a and u 74006f

ArticleYear
Inhibition of proliferation of fibroblasts by lazaroids (21-aminosteroids).
    Life sciences, 1991, Volume: 49, Issue:26

    Topics: Animals; Antioxidants; Cell Division; Cell Line; Cell Survival; DNA Replication; Ethylamines; Fibroblasts; Kinetics; L-Lactate Dehydrogenase; Mice; Mice, Inbred BALB C; Piperazines; Pregnatrienes; Probucol; Pyridines; Steroids; Vitamin E

1991
Evidence for 21-aminosteroid association with the hydrophobic domains of brain microvessel endothelial cells.
    Free radical biology & medicine, 1991, Volume: 11, Issue:4

    Topics: Animals; Cattle; Cells, Cultured; Cerebrovascular Circulation; Endothelium, Vascular; Fluorescence Polarization; Kinetics; Lipid Peroxides; Microcirculation; Pregnatrienes; Temperature

1991
21-Aminosteroids attenuate excitotoxic neuronal injury in cortical cell cultures.
    Neuron, 1990, Volume: 5, Issue:2

    Topics: Animals; Aspartic Acid; Cells, Cultured; Cerebral Cortex; Glucose; Lipid Peroxidation; Lipid Peroxides; Membrane Potentials; Mice; N-Methylaspartate; Nerve Degeneration; Neurons; Pregnatrienes; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter

1990
The 21-aminosteroid inhibitors of lipid peroxidation: reactions with lipid peroxyl and phenoxy radicals.
    Free radical biology & medicine, 1989, Volume: 7, Issue:2

    Topics: Antioxidants; Kinetics; Linoleic Acid; Linoleic Acids; Lipid Peroxidation; Lipid Peroxides; Peroxides; Phenols; Pregnatrienes

1989
Novel 21-amino steroids as potent inhibitors of iron-dependent lipid peroxidation.
    The Journal of biological chemistry, 1987, Aug-05, Volume: 262, Issue:22

    Topics: Animals; Brain; Butylated Hydroxytoluene; Cell Membrane; Deferoxamine; Iron; Lipid Peroxides; Pregnatrienes; Rats; Synaptosomes; Thiobarbiturates; Vitamin E

1987
21-aminosteroid and 2-(aminomethyl)chromans inhibition of arachidonic acid-induced lipid peroxidation and permeability enhancement in bovine brain microvessel endothelial cell monolayers.
    Free radical biology & medicine, 1995, Volume: 19, Issue:3

    Topics: Animals; Antioxidants; Arachidonic Acid; Brain; Capillary Permeability; Cattle; Cells, Cultured; Cerebrovascular Circulation; Chromans; Endothelium, Vascular; Fluorescence Polarization; Free Radical Scavengers; Lipid Peroxidation; Microcirculation; Piperazines; Pregnatrienes; Structure-Activity Relationship

1995
Kinetics and thermodynamics of emulsion delivery of lipophilic antioxidants to cells in culture.
    Chemistry and physics of lipids, 1995, May-22, Volume: 76, Issue:1

    Topics: Animals; Antioxidants; Drug Delivery Systems; Emulsions; Kinetics; Mice; Neuroblastoma; Neurons; Phosphatidylcholines; Pregnatrienes; Rats; Thermodynamics; Triolein; Tumor Cells, Cultured

1995
Antioxidant action of lazaroids.
    Methods in enzymology, 1994, Volume: 234

    Topics: Animals; Antioxidants; Brain; Cell Membrane; Lipid Bilayers; Lipid Peroxides; Models, Molecular; Molecular Conformation; Molecular Structure; Pregnatrienes; Rats; Structure-Activity Relationship; Synaptosomes

1994
Kinetic evaluation of lipophilic inhibitors of lipid peroxidation in DLPC liposomes.
    Free radical biology & medicine, 1994, Volume: 17, Issue:6

    Topics: Amidines; Antioxidants; Azo Compounds; Chromans; Chromatography, High Pressure Liquid; Free Radical Scavengers; Free Radicals; Kinetics; Linoleic Acid; Linoleic Acids; Lipid Peroxidation; Liposomes; Mass Spectrometry; Nitriles; Phosphatidylcholines; Piperazines; Pregnatrienes

1994
Inhibition of S-(1,2-dichlorovinyl)-L-cysteine-induced lipid peroxidation by antioxidants in rabbit renal cortical slices: dissociation of lipid peroxidation and toxicity.
    Journal of biochemical toxicology, 1994, Volume: 9, Issue:3

    Topics: Aminooxyacetic Acid; Animals; Antioxidants; Chromans; Cysteine; Deferoxamine; DNA; In Vitro Techniques; Kidney Cortex; Lipid Peroxidation; Male; Piperazines; Potassium; Pregnatrienes; Rabbits; Thiobarbituric Acid Reactive Substances

1994
Effects of 21-aminosteroids in neonatal rat cardiac myocyte cell cultures exposed to free radicals.
    Cardiovascular research, 1994, Volume: 28, Issue:10

    Topics: Animals; Antioxidants; Arachidonic Acid; Cells, Cultured; Free Radical Scavengers; Free Radicals; Heart; L-Lactate Dehydrogenase; Lipid Peroxides; Myocardium; Pregnatrienes; Rats; Steroids; Xanthine Oxidase

1994
Inhibition of in vitro lipid peroxidation by 21-aminosteroids. Evidence for differential mechanisms.
    Biochemical pharmacology, 1993, Sep-01, Volume: 46, Issue:5

    Topics: Animals; Dose-Response Relationship, Drug; Down-Regulation; Ferric Compounds; Ferrous Compounds; Ferrozine; Lipid Peroxidation; Liposomes; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Pregnatrienes; Rats; Rats, Sprague-Dawley; Thiobarbituric Acid Reactive Substances; Time Factors

1993
The effects of 21-aminosteroids on the redox status of iron in solution.
    Archives of biochemistry and biophysics, 1993, Feb-01, Volume: 300, Issue:2

    Topics: Adenosine Diphosphate; Antioxidants; Ascorbic Acid; Ferrozine; Iron; Kinetics; Molecular Structure; Oxidation-Reduction; Pregnatrienes; Solutions; Structure-Activity Relationship; Time Factors

1993
Effects of lazaroids and a peroxynitrite scavenger in a cell model of peroxynitrite toxicity.
    Free radical biology & medicine, 1997, Volume: 22, Issue:1-2

    Topics: Animals; Antioxidants; Cells, Cultured; Cerebellum; Free Radical Scavengers; Models, Biological; Neuroprotective Agents; Nitrates; Pregnatrienes; Pyrimidines; Pyrroles; Pyrrolidines; Pyrrolidinones; Rats; Rats, Sprague-Dawley

1997
Comparison of various lazaroid compounds for protection against ischemic liver injury.
    Transplantation, 1997, Jan-27, Volume: 63, Issue:2

    Topics: Animals; Antioxidants; Dogs; Female; Ischemia; L-Lactate Dehydrogenase; Lipid Peroxidation; Liver; Liver Function Tests; Malondialdehyde; Neovascularization, Pathologic; Pregnatrienes; Reperfusion Injury

1997
Lazaroid U74500A is superior to U74006F in preserving rabbit heart for 24 hours.
    The Annals of thoracic surgery, 1998, Volume: 66, Issue:5

    Topics: Animals; Antioxidants; Cross Circulation; Free Radical Scavengers; In Vitro Techniques; Myocardial Reperfusion Injury; Myocardium; Oxygen Consumption; Pregnatrienes; Purines; Rabbits

1998
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