u 74500a and u 74006f
u 74500a has been researched along with u 74006f in 18 studies
Compound Research Comparison
| Studies (u 74500a) | Trials (u 74500a) | Recent Studies (post-2010) (u 74500a) | Studies (u 74006f) | Trials (u 74006f) | Recent Studies (post-2010) (u 74006f) |
|---|---|---|---|---|---|
| 81 | 0 | 2 | 362 | 49 | 11 |
Protein Interaction Comparison
| Protein | Taxonomy | u 74500a (IC50) | u 74006f (IC50) |
|---|---|---|---|
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | 0.718 | |
| Tyrosine-protein kinase Fyn | Homo sapiens (human) | 1.116 | |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | 7.898 | |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | 2.002 | |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | 0.718 | |
| Mitogen-activated protein kinase 14 | Homo sapiens (human) | 7.406 |
Research
Studies (18)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (11.11) | 18.7374 |
| 1990's | 16 (88.89) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Hall, ED | 1 |
| Bonin, PD; Singh, JP | 1 |
| Audus, KL; Braughler, JM; Guillot, FL | 1 |
| Choi, DW; Hartley, DM; Monyer, H | 1 |
| Braughler, JM; Pregenzer, JF | 1 |
| Braughler, JM; Chase, RL; Duncan, LA; Jacobsen, EJ; McCall, JM; Pregenzer, JF | 1 |
| Audus, KL; Cavitt, J; Shi, F | 1 |
| Buxser, SE; Decker, DE; Goodman, TG; Peterson, T; Vroegop, SM | 1 |
| Hall, ED; McCall, JM | 1 |
| Cazers, AR; Epps, DE; Horan, KL; Lutzke, BS; McCall, JM | 1 |
| Davis, JW; Petry, TW | 1 |
| Burton, KP | 1 |
| Hall, ED; McCall, JM; Means, ED | 1 |
| Pearson, PG; Petry, TW; Ryan, TP; Steenwyk, RC | 1 |
| Petry, TW; Ryan, TP | 1 |
| Althaus, JS; Fici, GJ; VonVoigtlander, PF | 1 |
| Ishizaki, N; Kobayashi, Y; Nemoto, A; Starzl, TE; Subbotin, V; Todo, S; Zhang, S; Zhu, Y | 1 |
| Kawachi, Y; Masuda, M; Morita, S; Nishida, T; Tominaga, R; Yasui, H | 1 |
Reviews
2 review(s) available for u 74500a and u 74006f
| Article | Year |
|---|---|
Novel inhibitors of iron-dependent lipid peroxidation for neurodegenerative disorders.
Topics: Animals; Antioxidants; Brain Diseases; Humans; Iron; Lipid Peroxidation; Nerve Degeneration; Pregnatrienes | 1992 |
Therapeutic potential of the lazaroids (21-aminosteroids) in acute central nervous system trauma, ischemia and subarachnoid hemorrhage.
Topics: Animals; Antioxidants; Brain; Brain Injuries; Brain Ischemia; Humans; Lipid Peroxidation; Lipid Peroxides; Methylprednisolone; Pregnatrienes; Spinal Cord Injuries; Subarachnoid Hemorrhage | 1994 |
Other Studies
16 other study(ies) available for u 74500a and u 74006f
| Article | Year |
|---|---|
Inhibition of proliferation of fibroblasts by lazaroids (21-aminosteroids).
Topics: Animals; Antioxidants; Cell Division; Cell Line; Cell Survival; DNA Replication; Ethylamines; Fibroblasts; Kinetics; L-Lactate Dehydrogenase; Mice; Mice, Inbred BALB C; Piperazines; Pregnatrienes; Probucol; Pyridines; Steroids; Vitamin E | 1991 |
Evidence for 21-aminosteroid association with the hydrophobic domains of brain microvessel endothelial cells.
Topics: Animals; Cattle; Cells, Cultured; Cerebrovascular Circulation; Endothelium, Vascular; Fluorescence Polarization; Kinetics; Lipid Peroxides; Microcirculation; Pregnatrienes; Temperature | 1991 |
21-Aminosteroids attenuate excitotoxic neuronal injury in cortical cell cultures.
Topics: Animals; Aspartic Acid; Cells, Cultured; Cerebral Cortex; Glucose; Lipid Peroxidation; Lipid Peroxides; Membrane Potentials; Mice; N-Methylaspartate; Nerve Degeneration; Neurons; Pregnatrienes; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
The 21-aminosteroid inhibitors of lipid peroxidation: reactions with lipid peroxyl and phenoxy radicals.
Topics: Antioxidants; Kinetics; Linoleic Acid; Linoleic Acids; Lipid Peroxidation; Lipid Peroxides; Peroxides; Phenols; Pregnatrienes | 1989 |
Novel 21-amino steroids as potent inhibitors of iron-dependent lipid peroxidation.
Topics: Animals; Brain; Butylated Hydroxytoluene; Cell Membrane; Deferoxamine; Iron; Lipid Peroxides; Pregnatrienes; Rats; Synaptosomes; Thiobarbiturates; Vitamin E | 1987 |
21-aminosteroid and 2-(aminomethyl)chromans inhibition of arachidonic acid-induced lipid peroxidation and permeability enhancement in bovine brain microvessel endothelial cell monolayers.
Topics: Animals; Antioxidants; Arachidonic Acid; Brain; Capillary Permeability; Cattle; Cells, Cultured; Cerebrovascular Circulation; Chromans; Endothelium, Vascular; Fluorescence Polarization; Free Radical Scavengers; Lipid Peroxidation; Microcirculation; Piperazines; Pregnatrienes; Structure-Activity Relationship | 1995 |
Kinetics and thermodynamics of emulsion delivery of lipophilic antioxidants to cells in culture.
Topics: Animals; Antioxidants; Drug Delivery Systems; Emulsions; Kinetics; Mice; Neuroblastoma; Neurons; Phosphatidylcholines; Pregnatrienes; Rats; Thermodynamics; Triolein; Tumor Cells, Cultured | 1995 |
Antioxidant action of lazaroids.
Topics: Animals; Antioxidants; Brain; Cell Membrane; Lipid Bilayers; Lipid Peroxides; Models, Molecular; Molecular Conformation; Molecular Structure; Pregnatrienes; Rats; Structure-Activity Relationship; Synaptosomes | 1994 |
Kinetic evaluation of lipophilic inhibitors of lipid peroxidation in DLPC liposomes.
Topics: Amidines; Antioxidants; Azo Compounds; Chromans; Chromatography, High Pressure Liquid; Free Radical Scavengers; Free Radicals; Kinetics; Linoleic Acid; Linoleic Acids; Lipid Peroxidation; Liposomes; Mass Spectrometry; Nitriles; Phosphatidylcholines; Piperazines; Pregnatrienes | 1994 |
Inhibition of S-(1,2-dichlorovinyl)-L-cysteine-induced lipid peroxidation by antioxidants in rabbit renal cortical slices: dissociation of lipid peroxidation and toxicity.
Topics: Aminooxyacetic Acid; Animals; Antioxidants; Chromans; Cysteine; Deferoxamine; DNA; In Vitro Techniques; Kidney Cortex; Lipid Peroxidation; Male; Piperazines; Potassium; Pregnatrienes; Rabbits; Thiobarbituric Acid Reactive Substances | 1994 |
Effects of 21-aminosteroids in neonatal rat cardiac myocyte cell cultures exposed to free radicals.
Topics: Animals; Antioxidants; Arachidonic Acid; Cells, Cultured; Free Radical Scavengers; Free Radicals; Heart; L-Lactate Dehydrogenase; Lipid Peroxides; Myocardium; Pregnatrienes; Rats; Steroids; Xanthine Oxidase | 1994 |
Inhibition of in vitro lipid peroxidation by 21-aminosteroids. Evidence for differential mechanisms.
Topics: Animals; Dose-Response Relationship, Drug; Down-Regulation; Ferric Compounds; Ferrous Compounds; Ferrozine; Lipid Peroxidation; Liposomes; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Pregnatrienes; Rats; Rats, Sprague-Dawley; Thiobarbituric Acid Reactive Substances; Time Factors | 1993 |
The effects of 21-aminosteroids on the redox status of iron in solution.
Topics: Adenosine Diphosphate; Antioxidants; Ascorbic Acid; Ferrozine; Iron; Kinetics; Molecular Structure; Oxidation-Reduction; Pregnatrienes; Solutions; Structure-Activity Relationship; Time Factors | 1993 |
Effects of lazaroids and a peroxynitrite scavenger in a cell model of peroxynitrite toxicity.
Topics: Animals; Antioxidants; Cells, Cultured; Cerebellum; Free Radical Scavengers; Models, Biological; Neuroprotective Agents; Nitrates; Pregnatrienes; Pyrimidines; Pyrroles; Pyrrolidines; Pyrrolidinones; Rats; Rats, Sprague-Dawley | 1997 |
Comparison of various lazaroid compounds for protection against ischemic liver injury.
Topics: Animals; Antioxidants; Dogs; Female; Ischemia; L-Lactate Dehydrogenase; Lipid Peroxidation; Liver; Liver Function Tests; Malondialdehyde; Neovascularization, Pathologic; Pregnatrienes; Reperfusion Injury | 1997 |
Lazaroid U74500A is superior to U74006F in preserving rabbit heart for 24 hours.
Topics: Animals; Antioxidants; Cross Circulation; Free Radical Scavengers; In Vitro Techniques; Myocardial Reperfusion Injury; Myocardium; Oxygen Consumption; Pregnatrienes; Purines; Rabbits | 1998 |