Page last updated: 2024-09-02

u 74500a and allopurinol

u 74500a has been researched along with allopurinol in 6 studies

Compound Research Comparison

Studies
(u 74500a)
Trials
(u 74500a)
Recent Studies (post-2010)
(u 74500a)
Studies
(allopurinol)
Trials
(allopurinol)
Recent Studies (post-2010) (allopurinol)
810215,0967433,363

Protein Interaction Comparison

ProteinTaxonomyu 74500a (IC50)allopurinol (IC50)
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase Rattus norvegicus (Norway rat)3.3765
Xanthine dehydrogenase/oxidaseHomo sapiens (human)3.1861
Xanthine dehydrogenase/oxidaseBos taurus (cattle)5.0758
Histamine H3 receptorCavia porcellus (domestic guinea pig)8.69

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Aeba, R; Griffith, BP; Hamamoto, I; Hardesty, RL; Keenan, RJ; Killinger, WA; Yousem, SA1
Klonowski, H; Niederau, C; Schulz, HU1
Benedict, CR; Pakala, R1
Mombourquette, MJ; Richardson, JS; Weil, JA; Zhao, W1
Burton, KP1
Gasbarrini, A; Jacobsson, J; Rilo, HL; Starzl, TE; Sundberg, R; Van Thiel, D1

Other Studies

6 other study(ies) available for u 74500a and allopurinol

ArticleYear
Lazaroid U74500A as an additive to University of Wisconsin solution for pulmonary grafts in the rat transplant model.
    The Journal of thoracic and cardiovascular surgery, 1992, Volume: 104, Issue:5

    Topics: Adenosine; Allopurinol; Animals; Body Water; Carbon Dioxide; Cardioplegic Solutions; Cold Temperature; Dexamethasone; Glutathione; Insulin; Ischemia; Lipid Peroxides; Lung; Male; Organ Preservation; Organ Preservation Solutions; Oxygen; Pregnatrienes; Raffinose; Rats; Rats, Inbred Lew; Reperfusion Injury; Solutions

1992
Lazaroids protect isolated rat pancreatic acinar cells against damage induced by free radicals.
    Pancreas, 1995, Volume: 11, Issue:2

    Topics: Adenosine Diphosphate; Animals; Antioxidants; Deoxyribose; Ethylamines; Free Radical Scavengers; Free Radicals; Hypoxanthine; Hypoxanthines; Iron; Kinetics; Male; Oxidation-Reduction; Pancreas; Pancreatitis; Piperazines; Pregnatrienes; Pyridines; Rats; Rats, Wistar; Xanthine Oxidase

1995
Novel 21-aminosteroidlike compounds prevent iron-induced free radical-mediated injury to vascular endothelial cells.
    Journal of cardiovascular pharmacology, 1995, Volume: 25, Issue:6

    Topics: Allopurinol; Animals; Antimetabolites; Antioxidants; Aorta; Butylated Hydroxytoluene; Cattle; Cell Count; Cell Membrane; Cell Survival; Chromans; Deferoxamine; Dogs; Endothelium, Vascular; Free Radical Scavengers; Free Radicals; Hydroxyl Radical; Iron; Iron Chelating Agents; Lipid Peroxidation; Piperazines; Pregnatrienes; Probucol; Pulmonary Artery; Siderophores

1995
An in vitro EPR study of the free-radical scavenging actions of the lazaroid antioxidants U-74500A and U-78517F.
    Free radical biology & medicine, 1995, Volume: 19, Issue:1

    Topics: Antioxidants; Chromans; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Ferrous Compounds; Free Radical Scavengers; Hydrogen Peroxide; Hydroxyl Radical; Hypoxanthine; Hypoxanthines; Piperazines; Pregnatrienes; Superoxides; Xanthine Oxidase

1995
Effects of 21-aminosteroids in neonatal rat cardiac myocyte cell cultures exposed to free radicals.
    Cardiovascular research, 1994, Volume: 28, Issue:10

    Topics: Animals; Antioxidants; Arachidonic Acid; Cells, Cultured; Free Radical Scavengers; Free Radicals; Heart; L-Lactate Dehydrogenase; Lipid Peroxides; Myocardium; Pregnatrienes; Rats; Steroids; Xanthine Oxidase

1994
Protective effects of the lazaroid U74500A and lidoflazine on liver preservation with UW solution.
    Transplant international : official journal of the European Society for Organ Transplantation, 1993, Volume: 6, Issue:5

    Topics: Adenosine; Alanine Transaminase; Allopurinol; Animals; Aspartate Aminotransferases; Glutathione; Insulin; L-Lactate Dehydrogenase; Lidoflazine; Lipid Peroxides; Liver; Male; Organ Preservation; Organ Preservation Solutions; Pregnatrienes; Raffinose; Rats; Rats, Inbred Lew; Reperfusion Injury

1993