u 73122 has been researched along with wortmannin in 55 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (18.18) | 18.2507 |
| 2000's | 38 (69.09) | 29.6817 |
| 2010's | 7 (12.73) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Bourgoin, S; Caon, AC; Gaudry, M; Gilbert, C; Naccache, PH; Poubelle, PE; Roberge, CJ | 1 |
| Suzuki, K; Takahashi, K; Tsukatani, Y | 1 |
| Katsura, Y; Masaki, T; Mazda, O; Miwa, S; Ninomiya, H; Okamoto, Y; Sugawara, F | 1 |
| McKinnon, M; Turner, SJ; Ward, SG; Westwick, J | 1 |
| Arita, Y; Hou, W; Morisset, J | 1 |
| Driessens, MH; Roos, E; Soede, RD; van Hulten, PE; van Rijthoven, EA | 1 |
| Barrington, M; Kotsonis, P; Majewski, H; Murphy, TV | 1 |
| Foyouzi-Youssefi, R; Krause, KH; Lew, DP; Monod, A; Nüsse, O; Serrander, L | 1 |
| Katsuki, H; Matsuki, N; Saito, H; Shitaka, Y | 1 |
| Alexandrov, A; Goepel, M; Keffel, S; Michel, MC | 1 |
| Fonnum, F; Voie, OA | 1 |
| Kamitori, K; Kohsaka, S; Machide, M | 1 |
| Araki, H; Kawabata, A; Kawai, K; Kuroda, R; Kuroki, N; Nishikawa, H | 1 |
| Aragona, F; Malendowicz, LK; Nussdorfer, GG; Rebuffat, P; Tortorella, C | 1 |
| Lipfert, L; Nakamura, I; Rodan, GA | 1 |
| Bird, GS; Braun, FJ; Broad, LM; Kurosaki, T; Lievremont, JP; Putney, JW | 1 |
| Chien, CS; Chiu, CT; Hsiao, LD; Lin, CC; Shyr, MH; Wang, CC; Yang, CM | 1 |
| Chang, LC; Wang, JP | 1 |
| Kito, K; Morishita, K; Nishida, K | 1 |
| Fowler, CJ; Hedin, HL; Nilsson, L | 1 |
| Caporali, S; Ceracchi, G; Distefano, E; Marino, M; Pallottini, V; Trentalance, A | 1 |
| Ford, DL; Gill, DL; Ma, HT; Venkatachalam, K | 1 |
| Bogyo, A; Chap, H; Paulhe, F; Perret, B; Racaud-Sultan, C | 1 |
| Cheema, M; Connor, JD; Gilani, AH; Rasheed, H; Rizvi, Z; Saeed, SA | 1 |
| Ache, BW; Hatt, H; Spehr, M; Wetzel, CH | 1 |
| Hayashi, K; Kadomatsu, K; Muramatsu, T | 1 |
| Agata, Y; Gonda, H; Hara, T; Katakai, T; Matsuda, E; Nambu, Y; Shimizu, A; Sugai, M | 1 |
| Arnhold, J; Petković, M; Vocks, A | 1 |
| Francis, K; Ham, J; Lewis, BM; Lewis, MD; Rees, DA; Scanlon, MF | 1 |
| Farnell, MB; Genovese, K; He, H; Kogut, MH | 1 |
| Argent, RH; Atherton, JC; Letley, DP; Rittig, MG; Shaw, B; Thomas, RJ | 1 |
| Hashimoto, N; Kawanabe, Y; Masaki, T | 1 |
| Brink, CB; de Kock, SE; Harvey, BH; Stein, DJ; Viljoen, SL | 1 |
| Brill, JA; Fabian, L; Forer, A; Saul, D | 1 |
| Fujimoto, S; Imagawa, N; Kawakami-Honda, N; Nagai, K; Nagasawa, K | 1 |
| Chen, LW; Hsu, CM; Lin, MW | 1 |
| Ikejima, T; Liu, YQ; Onodera, S; Tashiro, S; You, S | 1 |
| Ferjan, I; Stempelj, M | 1 |
| Falcinelli, E; Gresele, P; Guglielmini, G; Torti, M | 1 |
| Du, XN; Jia, QZ; Wang, C; Zhang, HL | 1 |
| Calvès, P; Nonnotte, G; Nonnotte, L; Ollivier, H; Pichavant-Rafini, K; Puill-Stephan, E | 1 |
| Hong, BZ; Kang, HS; Kim, HN; Kim, KR; Kim, SJ; Kwak, YG; Park, SA; So, JN | 1 |
| Gregory-Evans, C; Ignatov, A; Robert, J; Schaller, HC | 1 |
| Ewart, MA; Hardie, DG; Reihill, JA; Salt, IP | 1 |
| Crawford, SE; Estes, MK; Höök, M; Hyser, JM; Kim, KJ; Seo, NS; Utama, B; Zeng, CQ | 1 |
| Herness, S; Zhao, FL | 1 |
| Hong, BZ; Kang, HS; Kim, HG; Kim, HN; Kwak, YG; Ma, TZ; Park, SA | 1 |
| Bomben, VC; Bulk, E; Fabian, A; Fortmann, T; Schwab, A; Sontheimer, H | 1 |
| Mironov, SL; Skorova, EY | 1 |
| Cianflone, K; Jiao, ZY; Lin, HH; Lu, HL; Wu, J; Zhang, J | 1 |
| Diéguez, G; Fernández, N; García-Villalón, AL; Monge, L | 1 |
| Goto, K; Ichishima, K; Kansui, Y; Kitazono, T; Matsumura, K; Murakami, N; Ohtsubo, T | 1 |
| Choi, SH; Hwang, SH; Kim, BR; Kim, HJ; Lee, BH; Lee, SM; Nah, SY; Rhim, H; Shin, TJ | 1 |
| Barr, KN; Diaz, HL; Firkins, JL; Godden, KR; Plank, JE; Schappacher, AN; Wick, MP; Zapata, I | 1 |
1 trial(s) available for u 73122 and wortmannin
| Article | Year |
|---|---|
Eukaryotic inhibitors or activators elicit responses to chemosensory compounds by ruminal isotrichid and entodiniomorphid protozoa.
Topics: Androstadienes; Animals; Cattle; Chemotaxis; Ciliophora; Estrenes; Glucose; Guanosine Triphosphate; Nitroprusside; Peptides; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyrrolidinones; Rumen; Signal Transduction; Wortmannin | 2014 |
54 other study(ies) available for u 73122 and wortmannin
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Inhibition of tyrosine phosphorylation by wortmannin in human neutrophils. Dissociation from its inhibitory effects on phospholipase D.
Topics: Androstadienes; Biological Transport; Calcium; Enzyme Activation; Estrenes; Humans; Neutrophils; Phospholipase D; Phosphorylation; Pyrrolidinones; Type C Phospholipases; Tyrosine; Wortmannin | 1993 |
Inhibition of demecolcin-induced DNA synthesis by inhibitors of phospholipase C and protein kinase C.
Topics: Androstadienes; Breast; Cell Line; Cinnamates; Demecolcine; DNA; DNA Replication; Enzyme Inhibitors; Epidermal Growth Factor; Epithelium; ErbB Receptors; Estrenes; Female; Humans; Kinetics; Microtubules; Naphthalenes; Nitriles; Phosphorylation; Protein Kinase C; Pyrrolidinones; Type C Phospholipases; Tyrphostins; Wortmannin | 1996 |
Endothelin-1-induced mitogenic responses of Chinese hamster ovary cells expressing human endothelinA: the role of a wortmannin-sensitive signaling pathway.
Topics: Amino Acid Sequence; Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; CHO Cells; Cricetinae; Cytochrome P-450 Enzyme Inhibitors; Drug Interactions; Endothelins; Enzyme Activation; Estrenes; Guinea Pigs; Humans; Molecular Sequence Data; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Phosphotransferases (Alcohol Group Acceptor); Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Pyrrolidinones; Receptor, Endothelin A; Receptors, Endothelin; Sensitivity and Specificity; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Wortmannin | 1996 |
Stimulation of signal transduction pathways by MCP-1 in human monocytes and THP-1 cells.
Topics: Androstadienes; Calcium; Cell Line; Chemokine CCL2; Econazole; Egtazic Acid; Enzyme Inhibitors; Estrenes; Humans; Kinetics; Monocytes; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphotransferases (Alcohol Group Acceptor); Pyrrolidinones; Signal Transduction; Type C Phospholipases; Wortmannin | 1996 |
Caerulein-stimulated arachidonic acid release in rat pancreatic acini: a diacylglycerol lipase affair.
Topics: Androstadienes; Animals; Arachidonic Acid; Aristolochic Acids; Carbachol; Cells, Cultured; Ceruletide; Cyclohexanones; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Estrenes; Kinetics; Lipoprotein Lipase; Lipoxygenase Inhibitors; Male; Pancreas; Phenanthrenes; Phospholipase D; Phospholipases A; Phospholipases A2; Pyrrolidinones; Quinacrine; Rats; Rats, Sprague-Dawley; Wortmannin | 1996 |
Activation of G-proteins with AIF-4 induces LFA-1-mediated adhesion of T-cell hybridoma cells to ICAM-1 by signal pathways that differ from phorbol ester- and manganese-induced adhesion.
Topics: Aluminum Compounds; Androstadienes; Animals; Cell Adhesion; Enzyme Activation; Enzyme Inhibitors; Estrenes; Fluorides; Genistein; GTP-Binding Proteins; Humans; Hybridomas; Indoles; Intercellular Adhesion Molecule-1; Isoflavones; Lymphocyte Function-Associated Antigen-1; Maleimides; Manganese; Mice; Neoplasm Invasiveness; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Diacylglycerol-Lyase; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Protein-Tyrosine Kinases; Pyrrolidinones; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate; Wortmannin | 1997 |
Noradrenaline release and the effect of endogenous activation of the phospholipase C/protein kinase C signalling pathway in rat atria.
Topics: Androstadienes; Animals; Atrial Function; Diacylglycerol Kinase; Electric Stimulation; Enzyme Activation; Enzyme Inhibitors; Estrenes; Heart Atria; Male; Norepinephrine; Phosphotransferases (Alcohol Group Acceptor); Piperidines; Protein Kinase C; Pyrrolidinones; Quinazolines; Quinazolinones; Rats; Rats, Sprague-Dawley; Signal Transduction; Type C Phospholipases; Wortmannin | 1997 |
Store-operated Ca2+ influx and stimulation of exocytosis in HL-60 granulocytes.
Topics: Androstadienes; Calcium; Cytoplasmic Granules; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Estrenes; Exocytosis; Genistein; Granulocytes; GTP-Binding Proteins; HL-60 Cells; Humans; N-Formylmethionine Leucyl-Phenylalanine; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Phospholipase D; Pyrrolidinones; Signal Transduction; Thapsigargin; Type C Phospholipases; Virulence Factors, Bordetella; Wortmannin | 1997 |
A potential role of Ras-mediated signal transduction for the enhancement of depolarization-induced Ca2+ responses in hippocampal neurons by basic fibroblast growth factor.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Androstadienes; Animals; Antimanic Agents; Calcium; Calcium Channels; Calcium Channels, N-Type; Carcinogens; Cells, Cultured; Colforsin; Cyclic AMP; Electrophysiology; Enzyme Inhibitors; Estrenes; Fibroblast Growth Factor 2; Hippocampus; Lithium Chloride; Membrane Potentials; Naphthalenes; Neurons; Phosphodiesterase Inhibitors; Protein Kinase C; Proto-Oncogene Proteins c-raf; Pyrrolidinones; ras Proteins; Rats; Rats, Wistar; Signal Transduction; Tetradecanoylphorbol Acetate; Wortmannin | 1998 |
Differential regulation of 46 and 54 kDa jun N-terminal kinases and p38 mitogen-activated protein kinase by human alpha(1A)-adrenoceptors expressed in Rat-1 cells.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Estrenes; Gene Expression; Humans; Indoles; JNK Mitogen-Activated Protein Kinases; Kinetics; Maleimides; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phenylephrine; Phosphoinositide-3 Kinase Inhibitors; Prazosin; Protein Kinase C; Pyrrolidinones; Rats; Receptors, Adrenergic, alpha-1; Tetradecanoylphorbol Acetate; Transfection; Type C Phospholipases; Virulence Factors, Bordetella; Wortmannin | 1999 |
Effect of polychlorinated biphenyls on production of reactive oxygen species (ROS) in rat synaptosomes.
Topics: Androstadienes; Animals; Environmental Pollutants; Estrenes; Ethanol; Fluoresceins; Hydrogen Peroxide; Male; Methylmercury Compounds; Phosphodiesterase Inhibitors; Polychlorinated Biphenyls; Pyrrolidinones; Rats; Rats, Wistar; Reactive Oxygen Species; Synaptosomes; Type C Phospholipases; Wortmannin | 2000 |
Hepatocyte growth factor-induced differential activation of phospholipase cgamma 1 and phosphatidylinositol 3-kinase is regulated by tyrosine phosphatase SHP-1 in astrocytes.
Topics: Actins; Androstadienes; Animals; Astrocytes; Blotting, Western; Cell Movement; Cells, Cultured; Cysteine; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Estrenes; Genes, Dominant; Hepatocyte Growth Factor; Intracellular Signaling Peptides and Proteins; Isoenzymes; Microscopy, Fluorescence; Mutation; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Phospholipase C gamma; Phosphorylation; Precipitin Tests; Protein Kinase C; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Pyrrolidinones; Rats; Rats, Wistar; Recombinant Proteins; Serine; Signal Transduction; Time Factors; Transfection; Type C Phospholipases; Vanadates; Wortmannin | 2000 |
Characterization of the protease-activated receptor-1-mediated contraction and relaxation in the rat duodenal smooth muscle.
Topics: Androstadienes; Animals; Apamin; Calcium; Calcium Channel Blockers; Dose-Response Relationship, Drug; Duodenum; Enzyme Inhibitors; Estrenes; Genistein; Glycolates; Imidazoles; Indoles; Maleimides; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Nifedipine; Pyrrolidinones; Rats; Rats, Wistar; Receptor, PAR-1; Receptors, Thrombin; Sodium; Wortmannin | 2000 |
Signaling pathways involved in the A and B receptor-mediated cortisol secretagogue effect of endothelins in the human adrenal cortex.
Topics: Adenine; Androstadienes; Cells, Cultured; Endothelin Receptor Antagonists; Endothelins; Enzyme Inhibitors; Estrenes; Flavonoids; Humans; Hydrocortisone; Indomethacin; Naphthalenes; Nifedipine; Oligopeptides; Peptides, Cyclic; Phosphoinositide-3 Kinase Inhibitors; Piperidines; Protein Kinase C; Pyrazoles; Pyrrolidinones; Receptors, Endothelin; Signal Transduction; Type C Phospholipases; Tyrphostins; Wortmannin; Zona Fasciculata; Zona Reticularis | 2001 |
Convergence of alpha(v)beta(3) integrin- and macrophage colony stimulating factor-mediated signals on phospholipase Cgamma in prefusion osteoclasts.
Topics: Androstadienes; Animals; Cell Adhesion; Cell Fusion; Cells, Cultured; Crk-Associated Substrate Protein; Cytoskeletal Proteins; Enzyme Inhibitors; Estrenes; Focal Adhesion Kinase 2; Isoenzymes; Macrophage Colony-Stimulating Factor; Mice; Mice, Inbred BALB C; Mice, Knockout; Osteoclasts; Paxillin; Phosphatidylinositol 3-Kinases; Phospholipase C gamma; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Pyrrolidinones; Receptors, Vitronectin; Retinoblastoma-Like Protein p130; Signal Transduction; Spleen; src-Family Kinases; Type C Phospholipases; Vitronectin; Wortmannin | 2001 |
Role of the phospholipase C-inositol 1,4,5-trisphosphate pathway in calcium release-activated calcium current and capacitative calcium entry.
Topics: Androstadienes; Animals; B-Lymphocytes; Boron Compounds; Calcium; Calcium Channels; Cell Line, Transformed; Cells, Cultured; Chickens; Enzyme Inhibitors; Estrenes; Heparin; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Kinetics; Lacrimal Apparatus; Leukemia, Basophilic, Acute; Mice; Phosphatidylinositol Phosphates; Pyrrolidinones; Rats; Receptors, Cytoplasmic and Nuclear; Thapsigargin; Tumor Cells, Cultured; Type C Phospholipases; Wortmannin | 2001 |
Mechanisms of thrombin-induced MAPK activation associated with cell proliferation in human cultured tracheal smooth muscle cells.
Topics: Androstadienes; Benzoquinones; Blotting, Western; Cell Division; Cells, Cultured; Chelating Agents; Chromones; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Estrenes; Flavonoids; Genistein; Humans; Indoles; Lactams, Macrocyclic; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Muscle, Smooth; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphorylation; Plasmids; Protein Isoforms; Protein Kinase C; Proto-Oncogene Proteins c-raf; Pyrrolidinones; Quinones; ras Proteins; Rifabutin; Thrombin; Time Factors; Trachea; Transfection; Virulence Factors, Bordetella; Wortmannin | 2001 |
Signal transduction pathways for activation of extracellular signal-regulated kinase by arachidonic acid in rat neutrophils.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Androstadienes; Animals; Arachidonic Acid; Arachidonic Acids; Butadienes; Calcium; Carbazoles; Chelating Agents; Chromones; Cyclooxygenase Inhibitors; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Estrenes; Flavonoids; GTP-Binding Protein alpha Subunits, Gi-Go; Heterotrimeric GTP-Binding Proteins; Indoles; Lipoxygenase Inhibitors; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Neutrophils; Nitriles; Pertussis Toxin; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Processing, Post-Translational; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Type C Phospholipases; Virulence Factors, Bordetella; Wortmannin | 2001 |
MCP-1 receptor binding affinity is up-regulated by pre-stimulation with MCP-1 in an actin polymerization-dependent manner.
Topics: Actins; Androstadienes; Biopolymers; Cell Line; Chemokine CCL2; Chemotaxis; Cytochalasin B; Enzyme Inhibitors; Estrenes; GTP-Binding Proteins; Humans; Macromolecular Substances; Monocytes; Pertussis Toxin; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoinositide-3 Kinase Inhibitors; Polymerase Chain Reaction; Protein Binding; Protein Kinase C; Pyrrolidinones; Receptors, CCR2; Receptors, Chemokine; Recombinant Fusion Proteins; Recombinant Proteins; Signal Transduction; Staurosporine; Transcription, Genetic; Transfection; Tumor Cells, Cultured; Type C Phospholipases; Virulence Factors, Bordetella; Wortmannin | 2001 |
Effects of staurosporine, U-73122, wortmannin, 4-hydroxynonenal and sodium azide upon the release of secreted beta-amyloid precursor protein from human platelets in response to thrombin stimulation.
Topics: Aldehydes; Amyloid beta-Protein Precursor; Androstadienes; Blood Platelets; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estrenes; Humans; Hydrogen Peroxide; In Vitro Techniques; Phospholipases A; Pyrrolidinones; Sodium Azide; Staurosporine; Thrombin; Type C Phospholipases; Wortmannin | 2001 |
beta-estradiol stimulation of DNA synthesis requires different PKC isoforms in HepG2 and MCF7 cells.
Topics: Androstadienes; Breast Neoplasms; Carcinoma, Hepatocellular; Cell Division; Cell Membrane; DNA Replication; Enzyme Inhibitors; Estradiol; Estrenes; Female; Humans; Indoles; Isoenzymes; Liver Neoplasms; Neomycin; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein Kinase C-alpha; Protein Synthesis Inhibitors; Pyrrolidinones; Signal Transduction; Stimulation, Chemical; Thymidine; Tritium; Tumor Cells, Cultured; Type C Phospholipases; Wortmannin | 2001 |
Expression of functional receptor-coupled TRPC3 channels in DT40 triple receptor InsP3 knockout cells.
Topics: Androstadienes; Animals; Animals, Genetically Modified; B-Lymphocytes; Calcium; Calcium Channels; Cell Line; Cells, Cultured; Chickens; DNA, Complementary; Enzyme Inhibitors; Enzyme Precursors; Estrenes; Inositol 1,4,5-Trisphosphate Receptors; Intracellular Signaling Peptides and Proteins; Ion Channels; Isoenzymes; Mice; Mutation; Phospholipase C gamma; Plasmids; Protein-Tyrosine Kinases; Pyrrolidinones; Receptors, Antigen, B-Cell; Receptors, Cytoplasmic and Nuclear; Syk Kinase; Time Factors; Transfection; TRPC Cation Channels; Type C Phospholipases; Wortmannin | 2001 |
Vascular smooth muscle cell spreading onto fibrinogen is regulated by calpains and phospholipase C.
Topics: Actins; Androstadienes; Animals; Calpain; Cell Adhesion; Cell Size; Chromones; Dipeptides; Enzyme Activation; Estrenes; Extracellular Matrix; Fibrinogen; Isoenzymes; Morpholines; Muscle, Smooth, Vascular; Phosphatidylinositol 3-Kinases; Phosphatidylinositols; Phosphoinositide-3 Kinase Inhibitors; Protein Binding; Protein Subunits; Pyrrolidinones; Swine; Type C Phospholipases; Wortmannin | 2001 |
Second messengers in platelet aggregation evoked by serotonin and A23187, a calcium ionophore.
Topics: Adult; Alkaloids; Androstadienes; Benzophenanthridines; Blood Platelets; Calcimycin; Calcium Channel Blockers; Cyproheptadine; Diltiazem; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Enzyme Inhibitors; Estrenes; Female; Genistein; Humans; In Vitro Techniques; Ionophores; Male; Methysergide; Phenanthridines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Platelet Aggregation; Pyrrolidinones; Second Messenger Systems; Serotonin; Type C Phospholipases; Verapamil; Wortmannin | 2001 |
3-phosphoinositides modulate cyclic nucleotide signaling in olfactory receptor neurons.
Topics: Adaptation, Physiological; Androstadienes; Animals; Calcium; Calcium Signaling; Cells, Cultured; Chromones; Electrophysiology; Enzyme Inhibitors; Estrenes; Morpholines; Nucleotides, Cyclic; Odorants; Olfactory Receptor Neurons; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phosphoinositide-3 Kinase Inhibitors; Pyrrolidinones; Rats; Rats, Wistar; Smell; Type C Phospholipases; Wortmannin | 2002 |
Requirement of chondroitin sulfate/dermatan sulfate recognition in midkine-dependent migration of macrophages.
Topics: Androstadienes; Animals; Benzoquinones; Carrier Proteins; Cell Movement; Chondroitin Sulfates; Cytokines; Dermatan Sulfate; Enzyme Inhibitors; Estrenes; Flavonoids; Humans; Lactams, Macrocyclic; Macrophages; Mice; Midkine; Protein Tyrosine Phosphatases; Pyrazoles; Pyrimidines; Pyrrolidinones; Quinones; Rats; Reverse Transcriptase Polymerase Chain Reaction; Rifabutin; RNA, Messenger; Signal Transduction; Wortmannin | 2001 |
Chemokine-independent preference for T-helper-1 cells in transendothelial migration.
Topics: Androstadienes; Animals; Autoimmune Diseases; Cell Movement; Cells, Cultured; Chemokines; Endothelium, Vascular; Enzyme Inhibitors; Estrenes; Mice; Mice, Inbred BALB C; Phosphoinositide-3 Kinase Inhibitors; Pyrrolidinones; Spleen; T-Lymphocytes, Helper-Inducer; Th1 Cells; Th2 Cells; Wortmannin | 2002 |
Involvement of phosphatidic acid in both degranulation and oxidative activity in fMet-Leu-Phe stimulated polymorphonuclear leukocytes.
Topics: 1-Butanol; Androstadienes; Aristolochic Acids; Cell Degranulation; Chromones; Cinnamates; Cytochalasin B; Cytoplasmic Granules; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estrenes; Humans; Luminescent Measurements; Models, Biological; Morpholines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pancreatic Elastase; Phosphatidic Acids; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phospholipase D; Phospholipases A; Protein Kinase C; Protein-Tyrosine Kinases; Pyrrolidinones; Reactive Oxygen Species; Staurosporine; Sulfides; Time Factors; Type C Phospholipases; Wortmannin | 2003 |
Adenosine-induced IL-6 expression in pituitary folliculostellate cells is mediated via A2b adenosine receptors coupled to PKC and p38 MAPK.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Androstadienes; Animals; Cells, Cultured; Dexamethasone; Estrenes; Indoles; Interleukin-6; Mice; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pituitary Gland, Anterior; Protein Kinase C; Pyrroles; Pyrrolidinones; Receptor, Adenosine A2B; Type C Phospholipases; Vascular Endothelial Growth Factors; Wortmannin | 2003 |
Pharmacological analysis of signal transduction pathways required for oxidative burst in chicken heterophils stimulated by a Toll-like receptor 2 agonist.
Topics: Androstadienes; Animals; Animals, Newborn; Carbazoles; Chickens; Estrenes; Flavonoids; Indoles; Lipopolysaccharides; Male; Membrane Glycoproteins; Neutrophils; Nitriles; Pyrrolidinones; Receptors, Cell Surface; Respiratory Burst; Signal Transduction; Sulfones; Teichoic Acids; Toll-Like Receptor 2; Toll-Like Receptors; Wortmannin | 2003 |
Helicobacter pylori-induced homotypic phagosome fusion in human monocytes is independent of the bacterial vacA and cag status.
Topics: Androstadienes; Bacterial Proteins; Cell Line; Chromones; Colony Count, Microbial; Epithelioid Cells; Estrenes; Gene Deletion; Genes, Bacterial; Helicobacter pylori; Humans; Microscopy, Electron; Microspheres; Mitogen-Activated Protein Kinase 1; Monocytes; Morpholines; Mutagenesis, Insertional; Phagosomes; Phosphoinositide-3 Kinase Inhibitors; Pyrrolidinones; Type C Phospholipases; Tyrphostins; Wortmannin | 2003 |
Characterization of G proteins involved in activation of nonselective cation channels and arachidonic acid release by norepinephrine/alpha1A-adrenergic receptors.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Agonists; Amides; Androstadienes; Animals; Arachidonic Acid; Calcium Channels; Cation Transport Proteins; CHO Cells; Cricetinae; Enzyme Inhibitors; Estrenes; GTP-Binding Proteins; Mutagenesis; Norepinephrine; Phosphodiesterase Inhibitors; Pyridines; Pyrrolidinones; Receptors, Adrenergic, alpha-1; Transfection; Wortmannin | 2004 |
Effects of myo-inositol versus fluoxetine and imipramine pretreatments on serotonin 5HT2A and muscarinic acetylcholine receptors in human neuroblastoma cells.
Topics: Adrenergic Uptake Inhibitors; Androstadienes; Atropine; Cell Line, Tumor; Enzyme Inhibitors; Estrenes; Fluoxetine; Humans; Imipramine; Inositol; Muscarinic Antagonists; Neuroblastoma; Phosphatidylinositols; Phosphodiesterase Inhibitors; Pyrrolidinones; Receptor, Serotonin, 5-HT2A; Receptors, Muscarinic; Selective Serotonin Reuptake Inhibitors; Tritium; Wortmannin | 2004 |
Continuous phosphatidylinositol metabolism is required for cleavage of crane fly spermatocytes.
Topics: Actins; Actomyosin; Androstadienes; Animals; Chromones; Cytokinesis; Diptera; Enzyme Inhibitors; Estrenes; Hydrolysis; Male; Microscopy, Confocal; Microscopy, Fluorescence; Microscopy, Phase-Contrast; Models, Biological; Morpholines; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Phosphorylation; Pyrrolidinones; Spermatocytes; Time Factors; Type C Phospholipases; Wortmannin | 2004 |
Protein kinase C-independent pathway for NADPH oxidase activation in guinea pig peritoneal polymorphonuclear leukocytes by cytochalasin D.
Topics: Androstadienes; Animals; Cytochalasin D; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Estrenes; Ethanol; Female; Guinea Pigs; Indoles; Maleimides; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Oxygen; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phospholipase D; Phosphoproteins; Protein Kinase C; Protein Transport; Pyrrolidinones; Signal Transduction; Subcellular Fractions; Wortmannin | 2005 |
Different pathways leading to activation of extracellular signal-regulated kinase and p38 MAP kinase by formyl-methionyl-leucyl-phenylalanine or platelet activating factor in human neutrophils.
Topics: Androstadienes; Aristolochic Acids; Calcium; Calcium Channel Blockers; Calcium Channels; Chromones; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estrenes; Extracellular Signal-Regulated MAP Kinases; Humans; Imidazoles; Indoles; Maleimides; Models, Biological; Morpholines; N-Formylmethionine Leucyl-Phenylalanine; Naphthalenes; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Phospholipases A; Phospholipases A2; Phosphorylation; Platelet Activating Factor; Protein Isoforms; Protein Kinase C; Pyrrolidinones; Type C Phospholipases; Wortmannin | 2005 |
Activation of phosphoinositide 3-kinase, protein kinase C, and extracellular signal-regulated kinase is required for oridonin-enhanced phagocytosis of apoptotic bodies in human macrophage-like U937 cells.
Topics: Androstadienes; Apoptosis; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Chromatography, High Pressure Liquid; Diterpenes; Diterpenes, Kaurane; Enzyme Activation; Enzyme Inhibitors; Estrenes; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Flow Cytometry; Humans; Molecular Structure; Phagocytosis; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Pyrrolidinones; Staurosporine; Time Factors; Type C Phospholipases; U937 Cells; Ultraviolet Rays; Wortmannin | 2005 |
Signaling pathway in nerve growth factor induced histamine release from rat mast cells.
Topics: Analysis of Variance; Androstadienes; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estrenes; Flavonoids; Histamine; Imidazoles; Indoles; Male; Maleimides; Mast Cells; Models, Biological; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Protein Kinase C; Pyridines; Pyrrolidinones; Rats; Rats, Wistar; Signal Transduction; Staurosporine; Tyrosine; Wortmannin | 2005 |
Intraplatelet signaling mechanisms of the priming effect of matrix metalloproteinase-2 on platelet aggregation.
Topics: Androstadienes; Blood Platelets; Calcium; Chromones; Drug Synergism; Estrenes; Humans; In Vitro Techniques; Indoles; Inositol 1,4,5-Trisphosphate; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Platelet Aggregation; Protein Kinase C; Pyrrolidinones; Recombinant Proteins; Second Messenger Systems; Signal Transduction; Thrombin; Tissue Inhibitor of Metalloproteinase-2; Type C Phospholipases; Wortmannin | 2005 |
Binding of PLCdelta1PH-GFP to PtdIns(4,5)P2 prevents inhibition of phospholipase C-mediated hydrolysis of PtdIns(4,5)P2 by neomycin.
Topics: Acetylcholine; Androstadienes; Animals; Bradykinin; Cell Membrane; Chlorocebus aethiops; COS Cells; Cytosol; Estrenes; Green Fluorescent Proteins; Hydrolysis; Isoenzymes; Neomycin; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphoinositide-3 Kinase Inhibitors; Phospholipase C delta; Protein Binding; Protein Transport; Pyrrolidinones; Receptor, Bradykinin B2; Receptors, Muscarinic; Type C Phospholipases; Wortmannin | 2005 |
Effects of hyposmotic stress on exocytosis in isolated turbot, Scophthalmus maximus, hepatocytes.
Topics: 1-Butanol; Alkaloids; Androstadienes; Animals; Benzophenanthridines; Cell Membrane; Colchicine; Cytochalasin B; Cytoskeleton; Estrenes; Exocytosis; Flatfishes; Fluorescent Dyes; Hepatocytes; Indomethacin; Ionomycin; Isoquinolines; Masoprocol; Osmotic Pressure; Phenanthridines; Pyridinium Compounds; Pyrrolidinones; Quaternary Ammonium Compounds; Quinacrine; Signal Transduction; Sulfonamides; Thapsigargin; Wortmannin | 2006 |
Vascular endothelial growth factor increases the intracellular magnesium.
Topics: Androstadienes; Cells, Cultured; Chromones; Cinnamates; Dose-Response Relationship, Drug; Endothelial Cells; Estrenes; Humans; Intracellular Fluid; Magnesium; Morpholines; Peptide Fragments; Phosphoinositide-3 Kinase Inhibitors; Phospholipase C gamma; Protein-Tyrosine Kinases; Pyrrolidinones; Signal Transduction; Tyrphostins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; Wortmannin | 2006 |
RANTES stimulates Ca2+ mobilization and inositol trisphosphate (IP3) formation in cells transfected with G protein-coupled receptor 75.
Topics: Amyloid beta-Peptides; Androstadienes; Animals; Calcium; Cell Line; Cell Survival; Chemokine CCL5; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Estrenes; Female; Gene Expression Profiling; Humans; Inosine Triphosphate; Luciferases; Luminescent Measurements; Male; Mice; Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyrrolidinones; Receptors, G-Protein-Coupled; Transfection; Wortmannin | 2006 |
AMP-activated protein kinase mediates VEGF-stimulated endothelial NO production.
Topics: Amino Acid Sequence; AMP-Activated Protein Kinases; Androstadienes; Benzimidazoles; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Endothelium, Vascular; Estrenes; Humans; Isoquinolines; Multienzyme Complexes; Naphthalimides; Nitric Oxide; Nitric Oxide Synthase Type III; Protein Serine-Threonine Kinases; Pyrrolidinones; Serine; Type C Phospholipases; Vascular Endothelial Growth Factor A; Wortmannin | 2007 |
Integrins alpha1beta1 and alpha2beta1 are receptors for the rotavirus enterotoxin.
Topics: Androstadienes; Animals; Binding Sites; Cell Adhesion; Cell Line; Cell Movement; Diarrhea; Enterotoxins; Enzyme-Linked Immunosorbent Assay; Estrenes; Glycoproteins; Humans; Integrin alpha1beta1; Integrin alpha2beta1; Mice; Protein Binding; Protein Structure, Tertiary; Protein Transport; Pyrrolidinones; Rotavirus; Signal Transduction; Surface Plasmon Resonance; Toxins, Biological; Viral Nonstructural Proteins; Wortmannin | 2008 |
Resynthesis of phosphatidylinositol 4,5-bisphosphate mediates adaptation of the caffeine response in rat taste receptor cells.
Topics: Androstadienes; Animals; Benzylamines; Caffeine; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Chromones; Delayed Rectifier Potassium Channels; Enzyme Inhibitors; Estrenes; Male; Morpholines; Patch-Clamp Techniques; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphoinositide-3 Kinase Inhibitors; Phospholipase C beta; Polylysine; Potassium Channels, Inwardly Rectifying; Protein Kinase C; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Serum Albumin, Bovine; Sulfonamides; Taste; Taste Buds; Tetradecanoylphorbol Acetate; Wortmannin | 2009 |
Basic fibroblast growth factor increases intracellular magnesium concentration through the specific signaling pathways.
Topics: Androstadienes; Cell Line; Chromones; Dose-Response Relationship, Drug; Endothelial Cells; Estrenes; Fibroblast Growth Factor 2; Flavonoids; Genistein; Humans; Imidazoles; Intracellular Space; Magnesium; Microscopy, Fluorescence; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phospholipase C gamma; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyridines; Pyrrolidinones; Signal Transduction; Tyrphostins; Wortmannin | 2009 |
Chemotaxis of MDCK-F cells toward fibroblast growth factor-2 depends on transient receptor potential canonical channel 1.
Topics: Androstadienes; Animals; Calcium; Calcium Signaling; Cell Line; Chemotaxis; Dogs; Estrenes; Fibroblast Growth Factor 2; Humans; Intercellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Peptides; Pyrrolidinones; Receptor, Fibroblast Growth Factor, Type 1; Spider Venoms; TRPC Cation Channels; Wortmannin | 2011 |
Stimulation of bursting in pre-Bötzinger neurons by Epac through calcium release and modulation of TRPM4 and K-ATP channels.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Androstadienes; Animals; Animals, Newborn; Biophysical Phenomena; Bradykinin; Brain Stem; Calcium; Cyclic AMP; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Estrenes; Excitatory Amino Acid Antagonists; Fluorescence Resonance Energy Transfer; In Vitro Techniques; KATP Channels; Membrane Potentials; Mice; Neurons; Patch-Clamp Techniques; Phosphatidylinositol 4,5-Diphosphate; Pyrrolidinones; TRPM Cation Channels; Wortmannin | 2011 |
The molecular mechanism of acylation stimulating protein regulation of adipophilin and perilipin expression: involvement of phosphoinositide 3-kinase and phospholipase C.
Topics: 3T3-L1 Cells; Androstadienes; Animals; Carrier Proteins; Complement C3; Electrophoresis, Polyacrylamide Gel; Estrenes; Immunoblotting; Intercellular Signaling Peptides and Proteins; Membrane Proteins; Mice; Peptides; Perilipin-1; Perilipin-2; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Pyrrolidinones; Reverse Transcriptase Polymerase Chain Reaction; Triglycerides; Type C Phospholipases; Wortmannin | 2011 |
Coronary response to diadenosine tetraphosphate after ischemia-reperfusion in the isolated rat heart.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Androstadienes; Animals; Coronary Vessels; Dinucleoside Phosphates; Endothelin-1; Estrenes; Glyburide; Heart; In Vitro Techniques; Indoles; Isatin; Isoquinolines; Male; Maleimides; NG-Nitroarginine Methyl Ester; Perfusion; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Rest; Sulfonamides; Triazines; Vasoconstriction; Wortmannin | 2011 |
Facilitation of sympathetic neurotransmission by phosphatidylinositol-4,5-bisphosphate-dependent regulation of KCNQ channels in rat mesenteric arteries.
Topics: Androstadienes; Animals; Bradykinin; Calcium; Calcium Channel Blockers; Electric Stimulation; Estrenes; Excitatory Postsynaptic Potentials; KCNQ Potassium Channels; Male; Membrane Potentials; Mesenteric Arteries; Microelectrodes; Neuromuscular Junction; omega-Conotoxin GVIA; Phosphatidylinositol 4,5-Diphosphate; Protein Kinase C; Pyrrolidinones; Rats; Rats, Wistar; Receptors, Purinergic; Sympathetic Nervous System; Synaptic Transmission; Type C Phospholipases; Wortmannin | 2012 |
Gintonin, a ginseng-derived lysophosphatidic acid receptor ligand, potentiates ATP-gated P2X₁ receptor channel currents.
Topics: Adenosine Triphosphate; Androstadienes; Animals; Binding Sites; Estrenes; Humans; Ion Channel Gating; Isoxazoles; Mutagenesis, Site-Directed; Oocytes; Panax; Phosphatidylinositols; Plant Extracts; Propionates; Pyrrolidinones; Receptors, Lysophosphatidic Acid; Receptors, Purinergic P2X1; Signal Transduction; Wortmannin; Xenopus laevis | 2013 |