u 73122 has been researched along with glycerophosphoinositol 4,5-bisphosphate in 42 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (14.29) | 18.2507 |
| 2000's | 27 (64.29) | 29.6817 |
| 2010's | 9 (21.43) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vickers, JD | 1 |
| Chen, P; Murphy-Ullrich, JE; Wells, A | 1 |
| Driessens, MH; Roos, E; Soede, RD; van Hulten, PE; van Rijthoven, EA | 1 |
| Gan, J; Iuvone, PM | 1 |
| Abdel-Latif, AA; Akhtar, RA; Ding, KH; Husain, S; Isales, CM | 1 |
| Horie, M; Takano, M; Xie, LH | 1 |
| Schulz, I; Sternfeld, L; Thévenod, F | 1 |
| Jin, T; Kobrinsky, E; Logothetis, DE; Mirshahi, T; Zhang, H | 1 |
| Assmann, G; Fobker, M; Höbbel, G; Junker, R; Nofer, JR; Seedorf, U; Tepel, M; von Eckardstein, A; Voss, R; Walter, M; Wolinska, I; Zidek, W | 1 |
| Hirayama, T; Katagiri, T; Shinozaki, K; Takahashi, S; Yamaguchi-Shinozaki, K | 1 |
| Austin, DA; Eichhorn, J; Kayali, AG; Webster, NJ | 1 |
| Cho, H; Earm, YE; Ho, WK; Ryu, SY; Youm, JB | 1 |
| Raucher, D; Sheetz, MP | 1 |
| Barros, F; de la Pena, P; Dupuy, SG; Garcia-Manso, D; Giraldez, T; Gomez-Varela, D | 1 |
| Loew, LM; Xu, C | 1 |
| Fujita, T; Isshiki, M; Mutoh, A | 1 |
| Brill, JA; Fabian, L; Forer, A; Saul, D | 1 |
| Akerman, KE; Danis, AS; Holmqvist, T; Krjukova, J; Kukkonen, JP | 1 |
| Caruso-Neves, C; Carvalho, TL; Einicker-Lamas, M; Lara, LS; Lopes, AG; Nogaroli, L; Oliveira, MM; Rangel, LB; Silva, IV; Vieyra, A | 1 |
| Abogadie, FC; Brown, DA; Filippov, AK; Hughes, S; Marsh, SJ; Tatulian, L; Winks, JS | 1 |
| Hilgemann, DW; Hille, B; Hirdes, W; Horowitz, LF; Mackie, K; Suh, BC | 1 |
| Du, XN; Jia, QZ; Wang, C; Zhang, HL | 1 |
| Kunzelmann, K; McMorran, B; Ousingsawat, J; Scharf, B; Scheidt, K; Schreiber, R; Wainwright, B | 1 |
| Hill, CE; Lan, WZ; Wang, PY | 1 |
| Naito, Y; Okada, M; Yagisawa, H | 1 |
| Cottier, S; Helling, D; Klahre, U; Kost, B; Possart, A | 1 |
| Aromataris, EC; Barritt, GJ; Castro, J; Jones, L; Litjens, T; Nguyen, T; Rychkov, GY | 1 |
| Cabot, PJ; Monteith, GR; Roberts-Thomson, SJ; Vetter, I; Wyse, BD | 1 |
| Gadella, TW; Munnik, T; van Leeuwen, W; Vermeer, JE | 1 |
| Liang, H; Liu, B; Liu, L; Zhang, H | 1 |
| Kerchove, CM; Lazari, MF; Luna, MS; Smaili, SS; Yamanouye, N; Zablith, MB | 1 |
| Herness, S; Zhao, FL | 1 |
| Benn, BS; Christakos, S; Rohacs, T; Thyagarajan, B | 1 |
| Burgdorf, C; Kurz, T; Richardt, G; Schäfer, U | 1 |
| Albert, AP; Ju, M; Large, WA; Saleh, SN; Shi, J | 1 |
| Ehara, T; Ichishima, K; Iwamoto, T; Yamamoto, S | 1 |
| Byrne, RD; Dumas, F; Hobday, TM; Larijani, B; Poccia, DL; Vincent, B | 1 |
| Mironov, SL; Skorova, EY | 1 |
| Mamenko, M; O'Neil, RG; Pochynyuk, O; Zaika, O | 1 |
| Goto, K; Ichishima, K; Kansui, Y; Kitazono, T; Matsumura, K; Murakami, N; Ohtsubo, T | 1 |
| Cao, CQ; Mo, G; Peleshok, JC; Ribeiro-da-Silva, A; Séguéla, P | 1 |
| Chun, JT; Kim, UH; Limatola, N; Park, DR; Santella, L; Vasilev, F | 1 |
42 other study(ies) available for u 73122 and glycerophosphoinositol 4,5-bisphosphate
| Article | Year |
|---|---|
U73122 affects the equilibria between the phosphoinositides as well as phospholipase C activity in unstimulated and thrombin-stimulated human and rabbit platelets.
Topics: Animals; Blood Platelets; Estrenes; Humans; Kinetics; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Platelet Aggregation; Pyrrolidinones; Rabbits; Stimulation, Chemical; Thrombin; Time Factors; Type C Phospholipases | 1993 |
A role for gelsolin in actuating epidermal growth factor receptor-mediated cell motility.
Topics: 3T3 Cells; Actin Cytoskeleton; Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Cell Membrane; Cell Movement; Down-Regulation; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Estrenes; Gelsolin; Isoenzymes; Mice; Molecular Sequence Data; Mutation; Oligonucleotides, Antisense; Peptide Fragments; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphodiesterase Inhibitors; Phospholipase C gamma; Pyrrolidinones; Signal Transduction; Type C Phospholipases | 1996 |
Activation of G-proteins with AIF-4 induces LFA-1-mediated adhesion of T-cell hybridoma cells to ICAM-1 by signal pathways that differ from phorbol ester- and manganese-induced adhesion.
Topics: Aluminum Compounds; Androstadienes; Animals; Cell Adhesion; Enzyme Activation; Enzyme Inhibitors; Estrenes; Fluorides; Genistein; GTP-Binding Proteins; Humans; Hybridomas; Indoles; Intercellular Adhesion Molecule-1; Isoflavones; Lymphocyte Function-Associated Antigen-1; Maleimides; Manganese; Mice; Neoplasm Invasiveness; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Diacylglycerol-Lyase; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Protein-Tyrosine Kinases; Pyrrolidinones; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate; Wortmannin | 1997 |
Depolarization and activation of dihydropyridine-sensitive Ca2+ channels stimulate inositol phosphate accumulation in photoreceptor-enriched chick retinal cell cultures.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Chick Embryo; Dihydropyridines; Electric Stimulation; Estrenes; Inositol Phosphates; Membrane Potentials; Nifedipine; Pertussis Toxin; Phosphatidylinositol 4,5-Diphosphate; Phosphodiesterase Inhibitors; Photoreceptor Cells; Potassium; Pyrrolidinones; Type C Phospholipases; Virulence Factors, Bordetella | 1997 |
Inhibition of muscarinic-stimulated polyphosphoinositide hydrolysis and Ca2+ mobilization in cat iris sphincter smooth muscle cells by cAMP-elevating agents.
Topics: Adrenergic beta-Agonists; Animals; Calcium; Carbachol; Cats; Cell Fractionation; Cell Membrane; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estrenes; Guanosine 5'-O-(3-Thiotriphosphate); Hydrolysis; Inositol 1,4,5-Trisphosphate; Iris; Isoproterenol; Kinetics; Muscarinic Agonists; Muscarinic Antagonists; Muscle, Smooth; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphodiesterase Inhibitors; Phosphorylation; Pyrrolidinones; Ryanodine; Thapsigargin; Type C Phospholipases | 1997 |
Phospholipase C-linked receptors regulate the ATP-sensitive potassium channel by means of phosphatidylinositol 4,5-bisphosphate metabolism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Adenosine Triphosphate; Dose-Response Relationship, Drug; Electric Conductivity; Estrenes; Guanosine Diphosphate; Phosphatidylinositol 4,5-Diphosphate; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Kinase C; Pyrrolidinones; Receptor, Muscarinic M1; Receptors, Muscarinic; Thionucleotides; Type C Phospholipases | 1999 |
fMLP-induced arachidonic acid release in db-cAMP-differentiated HL-60 cells is independent of phosphatidylinositol-4, 5-bisphosphate-specific phospholipase C activation and cytosolic phospholipase A(2) activation.
Topics: 1-Butanol; Arachidonic Acid; Arachidonic Acids; Bacterial Proteins; Bacterial Toxins; Bridged-Ring Compounds; Bucladesine; Calcimycin; Calcium; Cell Membrane; Cytosol; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Estrenes; HL-60 Cells; Humans; Indoles; Ionophores; Models, Biological; N-Formylmethionine Leucyl-Phenylalanine; Norbornanes; Phosphatidylinositol 4,5-Diphosphate; Phosphodiesterase Inhibitors; Phosphoinositide Phospholipase C; Phospholipase D; Phospholipases A; Phosphoric Diester Hydrolases; Phosphorylation; Precipitin Tests; Pyrrolidinones; Thiocarbamates; Thiones; Time Factors; Type C Phospholipases | 2000 |
Receptor-mediated hydrolysis of plasma membrane messenger PIP2 leads to K+-current desensitization.
Topics: Acetylcholine; Animals; Animals, Newborn; Cell Membrane; Cells, Cultured; COS Cells; Electric Conductivity; Enzyme Activation; ErbB Receptors; Estrenes; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Heart Atria; Heterotrimeric GTP-Binding Proteins; Hydrolysis; Ion Channel Gating; Oocytes; Phosphatidylinositol 4,5-Diphosphate; Potassium; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pyrrolidinones; Rats; Receptor Cross-Talk; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptors, Cell Surface; Receptors, Muscarinic; Second Messenger Systems; Type C Phospholipases; Xenopus laevis | 2000 |
Activation of phosphatidylinositol-specific phospholipase C by HDL-associated lysosphingolipid. Involvement in mitogenesis but not in cholesterol efflux.
Topics: Apolipoprotein A-I; Calcium Signaling; Cells, Cultured; Cholesterol; DNA; Egtazic Acid; Enzyme Activation; Estrenes; Fibroblasts; Humans; Lipoproteins, HDL; Lysophospholipids; Mitogens; Nickel; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoinositide Phospholipase C; Phosphorylcholine; Psychosine; Pyrrolidinones; Sphingolipids; Sphingosine; Tangier Disease; Type C Phospholipases | 2000 |
Hyperosmotic stress induces a rapid and transient increase in inositol 1,4,5-trisphosphate independent of abscisic acid in Arabidopsis cell culture.
Topics: Abscisic Acid; Arabidopsis; Arabidopsis Proteins; Calcium-Binding Proteins; Cells, Cultured; Enzyme Inhibitors; Estrenes; Gene Expression; Genes, Plant; Inositol 1,4,5-Trisphosphate; Neomycin; Osmotic Pressure; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoinositide Phospholipase C; Pyrrolidinones; Time Factors; Transcription Factors; Type C Phospholipases | 2001 |
Insulin activates phospholipase C-gamma1 via a PI-3 kinase dependent mechanism in 3T3-L1 adipocytes.
Topics: 3T3 Cells; Adipocytes; Animals; Biological Transport, Active; Diglycerides; Enzyme Activation; Estrenes; Glucose; Glucose Transporter Type 1; Glucose Transporter Type 4; Insulin; Isoenzymes; Mice; Monosaccharide Transport Proteins; Muscle Proteins; Phosphatidylinositol 3-Kinases; Phosphatidylinositol 4,5-Diphosphate; Phospholipase C gamma; Platelet-Derived Growth Factor; Pyrrolidinones; Type C Phospholipases | 2001 |
Inhibition of acetylcholine-activated K(+) currents by U73122 is mediated by the inhibition of PIP(2)-channel interaction.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Atrial Function; Dose-Response Relationship, Drug; Estrenes; Guanosine 5'-O-(3-Thiotriphosphate); Heart Atria; Membrane Potentials; Mice; Patch-Clamp Techniques; Phosphatidylinositol 4,5-Diphosphate; Phosphodiesterase Inhibitors; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Binding; Pyrrolidinones; Sodium | 2001 |
Phospholipase C activation by anesthetics decreases membrane-cytoskeleton adhesion.
Topics: 3T3 Cells; Anesthetics, Local; Animals; Antipsychotic Agents; Calcium; Cell Membrane; Cell Membrane Permeability; Chlorpromazine; Cytoskeleton; Enzyme Activation; Estrenes; Green Fluorescent Proteins; Lasers; Lidocaine; Luminescent Proteins; Mice; Micromanipulation; Microscopy, Confocal; Molecular Structure; Phosphatidylinositol 4,5-Diphosphate; Phospholipids; Pyrrolidinones; Recombinant Fusion Proteins; Type C Phospholipases | 2001 |
Protein kinase C is necessary for recovery from the thyrotropin-releasing hormone-induced r-ERG current reduction in GH3 rat anterior pituitary cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cells, Cultured; Enzyme Inhibitors; ERG1 Potassium Channel; Estrenes; Ether-A-Go-Go Potassium Channels; Hydrolysis; Indoles; Intracellular Signaling Peptides and Proteins; Isoenzymes; Maleimides; Membrane Potentials; Patch-Clamp Techniques; Phosphatidylinositol 4,5-Diphosphate; Phosphoprotein Phosphatases; Phosphorylation; Pituitary Gland, Anterior; Potassium Channels; Potassium Channels, Voltage-Gated; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Protein Phosphatase 2; Protein Serine-Threonine Kinases; Pyridines; Pyrrolidinones; Rats; rho-Associated Kinases; Signal Transduction; Thyrotropin-Releasing Hormone | 2003 |
Activation of phospholipase C increases intramembrane electric fields in N1E-115 neuroblastoma cells.
Topics: Animals; Bradykinin; Calcium; Cell Line, Tumor; Electromagnetic Fields; Enzyme Activation; Estrenes; Membrane Potentials; Mice; Neomycin; Neuroblastoma; Phosphatidylinositol 4,5-Diphosphate; Pyrrolidinones; Receptor, Bradykinin B2; Spectrometry, Fluorescence; Type C Phospholipases | 2003 |
Subcortical Ca2+ waves sneaking under the plasma membrane in endothelial cells.
Topics: Amino Acid Motifs; Calcium; Calcium Signaling; Calcium-Binding Proteins; Cell Compartmentation; Cell Membrane; Cytosol; Endothelial Cells; Endothelium, Vascular; Estrenes; Extracellular Fluid; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; GAP-43 Protein; Genes, Reporter; Green Fluorescent Proteins; Ion Transport; Isoenzymes; Membrane Proteins; Microscopy, Confocal; Nitric Oxide; Phosphatidylinositol 4,5-Diphosphate; Phospholipase C delta; Phospholipases A; Phospholipases A2; Protein Kinase C; Protein Kinase C beta; Protein Structure, Tertiary; Protein Transport; Pyrrolidinones; Recombinant Fusion Proteins; Type C Phospholipases | 2004 |
Continuous phosphatidylinositol metabolism is required for cleavage of crane fly spermatocytes.
Topics: Actins; Actomyosin; Androstadienes; Animals; Chromones; Cytokinesis; Diptera; Enzyme Inhibitors; Estrenes; Hydrolysis; Male; Microscopy, Confocal; Microscopy, Fluorescence; Microscopy, Phase-Contrast; Models, Biological; Morpholines; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Phosphorylation; Pyrrolidinones; Spermatocytes; Time Factors; Type C Phospholipases; Wortmannin | 2004 |
Phospholipase C activator m-3M3FBS affects Ca2+ homeostasis independently of phospholipase C activation.
Topics: Animals; Calcium; Cell Line, Tumor; CHO Cells; Cricetinae; Cytophotometry; Enzyme Activation; Enzyme Activators; Estrenes; Female; Fluorescent Dyes; Fura-2; Homeostasis; Humans; Muscarinic Agonists; Phosphatidylinositol 4,5-Diphosphate; Pyrrolidinones; Receptors, Muscarinic; Signal Transduction; Sulfonamides; Type C Phospholipases | 2004 |
PI-PLCbeta is involved in the modulation of the proximal tubule Na+-ATPase by angiotensin II.
Topics: Adenosine Triphosphatases; Angiotensin II; Animals; Cation Transport Proteins; Diglycerides; Estrenes; Isoenzymes; Kidney Tubules, Proximal; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Diacylglycerol-Lyase; Pyrrolidinones; Swine | 2005 |
Relationship between membrane phosphatidylinositol-4,5-bisphosphate and receptor-mediated inhibition of native neuronal M channels.
Topics: Animals; Animals, Newborn; Bradykinin; Calcium; Calcium-Binding Proteins; Cell Membrane; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Estrenes; Female; Fluorescent Dyes; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Gene Expression; Green Fluorescent Proteins; Immunohistochemistry; Isoenzymes; Male; Microscopy, Confocal; Muscarinic Agonists; Mutation; Neural Inhibition; Neuronal Calcium-Sensor Proteins; Neurons; Neuropeptides; Oxotremorine; Patch-Clamp Techniques; Phosphatidylinositol 4,5-Diphosphate; Phosphodiesterase Inhibitors; Phospholipase C delta; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Superior Cervical Ganglion; Transfection; Type C Phospholipases | 2005 |
Phospholipase C in living cells: activation, inhibition, Ca2+ requirement, and regulation of M current.
Topics: Alkylation; Animals; Calcium; CHO Cells; Cricetinae; Enzyme Activation; Estrenes; Ethylmaleimide; Humans; Inositol Phosphates; KCNQ Potassium Channels; KCNQ1 Potassium Channel; Membrane Potentials; Muscarinic Agonists; Oxotremorine; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Diacylglycerol-Lyase; Phospholipid Ethers; Potassium Channels, Voltage-Gated; Protein Kinase C; Pyrrolidinones; Receptor, Muscarinic M1; Sulfonamides; Time Factors; Transfection | 2005 |
Binding of PLCdelta1PH-GFP to PtdIns(4,5)P2 prevents inhibition of phospholipase C-mediated hydrolysis of PtdIns(4,5)P2 by neomycin.
Topics: Acetylcholine; Androstadienes; Animals; Bradykinin; Cell Membrane; Chlorocebus aethiops; COS Cells; Cytosol; Estrenes; Green Fluorescent Proteins; Hydrolysis; Isoenzymes; Neomycin; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphoinositide-3 Kinase Inhibitors; Phospholipase C delta; Protein Binding; Protein Transport; Pyrrolidinones; Receptor, Bradykinin B2; Receptors, Muscarinic; Type C Phospholipases; Wortmannin | 2005 |
Flagellin of Pseudomonas aeruginosa inhibits Na+ transport in airway epithelia.
Topics: Adenosine Triphosphate; Amiloride; Animals; Bronchi; Butadienes; Calcium Signaling; Cells, Cultured; Cystic Fibrosis; Egtazic Acid; Epithelial Cells; Epithelial Sodium Channels; Estrenes; Flagellin; G(M1) Ganglioside; Humans; Ion Transport; MAP Kinase Signaling System; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Inbred CFTR; Nitriles; Patch-Clamp Techniques; Phosphatidylinositol 4,5-Diphosphate; Pseudomonas aeruginosa; Pseudomonas Infections; Pyrrolidinones; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Respiratory Tract Infections; Sodium; Sodium Channels; Trachea | 2006 |
Modulation of hepatocellular swelling-activated K+ currents by phosphoinositide pathway-dependent protein kinase C.
Topics: Animals; Cell Size; Estrenes; Female; Hepatocytes; KCNQ1 Potassium Channel; Liver; Osmolar Concentration; Perfusion; Phosphatidylinositol 4,5-Diphosphate; Protein Kinase C; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Signal Transduction | 2006 |
Phospholipase C isoforms are localized at the cleavage furrow during cytokinesis.
Topics: Animals; Cell Line; Cytokinesis; Dogs; Estrenes; HeLa Cells; Humans; Isoenzymes; Mice; Microscopy, Fluorescence; NIH 3T3 Cells; Phosphatidylinositol 4,5-Diphosphate; Phospholipase C beta; Phospholipase C delta; Phospholipid Ethers; Pyrrolidinones; Type C Phospholipases | 2006 |
Pollen tube tip growth depends on plasma membrane polarization mediated by tobacco PLC3 activity and endocytic membrane recycling.
Topics: Amino Acid Sequence; Animals; Binding Sites; Calcium; Cell Membrane; Diglycerides; Endocytosis; Estrenes; Gene Expression Profiling; Gene Expression Regulation, Plant; Isoenzymes; Molecular Sequence Data; Mutation; Nicotiana; Phosphatidylinositol 4,5-Diphosphate; Plant Proteins; Pollen Tube; Protein Structure, Tertiary; Protein Transport; Pyrrolidinones; Recombinant Proteins; RNA, Messenger; Sequence Homology; Substrate Specificity; Type C Phospholipases | 2006 |
Phospholipase C-gamma1 is required for the activation of store-operated Ca2+ channels in liver cells.
Topics: Animals; Calcium; Calcium Channels; Cells, Cultured; Diglycerides; Estrenes; Hepatocytes; Inositol 1,4,5-Trisphosphate; Membrane Glycoproteins; Phosphatidylinositol 4,5-Diphosphate; Phospholipase C gamma; Pyrrolidinones; Rats; RNA, Small Interfering; Stromal Interaction Molecule 1; Thapsigargin; Transfection | 2007 |
Mechanisms involved in potentiation of transient receptor potential vanilloid 1 responses by ethanol.
Topics: Acetaldehyde; Analgesics, Opioid; Calcium; Capsaicin; Cell Line; Central Nervous System Depressants; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Diterpenes; Drug Synergism; Estrenes; Ethanol; Humans; Ion Channel Gating; Kidney; Morphine; Phosphatidylinositol 3-Kinases; Phosphatidylinositol 4,5-Diphosphate; Phosphodiesterase Inhibitors; Protein Kinase C; Pyrrolidinones; Radioligand Assay; Sensory System Agents; Tritium; TRPV Cation Channels | 2008 |
Visualization of phosphatidylinositol 4,5-bisphosphate in the plasma membrane of suspension-cultured tobacco BY-2 cells and whole Arabidopsis seedlings.
Topics: Arabidopsis; Cell Membrane; Cells, Cultured; Cytoplasm; Estrenes; Humans; Luminescent Proteins; Microscopy, Confocal; Nicotiana; Phosphatidylinositol 4,5-Diphosphate; Phosphodiesterase Inhibitors; Phospholipase C delta; Pyrrolidinones; Seedlings | 2007 |
Phosphatidylinositol 4,5-bisphosphate hydrolysis mediates histamine-induced KCNQ/M current inhibition.
Topics: Animals; Calcium; Cell Line; Cell Membrane; Estrenes; Histamine; Humans; Hydrolysis; Ion Channel Gating; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Neurons; Phosphatidylinositol 4,5-Diphosphate; Pyrilamine; Pyrrolidinones; Rats; Receptors, Histamine H1; Type C Phospholipases | 2008 |
Alpha1-adrenoceptors trigger the snake venom production cycle in secretory cells by activating phosphatidylinositol 4,5-bisphosphate hydrolysis and ERK signaling pathway.
Topics: Animals; Bothrops; Calcium; Enzyme Inhibitors; Estrenes; Extracellular Signal-Regulated MAP Kinases; Female; Male; MAP Kinase Signaling System; Phosphatidylinositol 4,5-Diphosphate; Protein Kinase C; Pyrrolidinones; Receptors, Adrenergic, alpha-1; Signal Transduction; Snake Venoms; Thapsigargin | 2008 |
Resynthesis of phosphatidylinositol 4,5-bisphosphate mediates adaptation of the caffeine response in rat taste receptor cells.
Topics: Androstadienes; Animals; Benzylamines; Caffeine; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Chromones; Delayed Rectifier Potassium Channels; Enzyme Inhibitors; Estrenes; Male; Morpholines; Patch-Clamp Techniques; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphoinositide-3 Kinase Inhibitors; Phospholipase C beta; Polylysine; Potassium Channels, Inwardly Rectifying; Protein Kinase C; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Serum Albumin, Bovine; Sulfonamides; Taste; Taste Buds; Tetradecanoylphorbol Acetate; Wortmannin | 2009 |
Phospholipase C-mediated regulation of transient receptor potential vanilloid 6 channels: implications in active intestinal Ca2+ transport.
Topics: Animals; Biological Transport, Active; Calcium; Calcium Channels; Cell Line; Estrenes; Humans; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Phosphatidylinositol 4,5-Diphosphate; Phospholipid Ethers; Pyrrolidinones; TRPV Cation Channels; Type C Phospholipases; Up-Regulation | 2009 |
U73122, an aminosteroid phospholipase C inhibitor, is a potent inhibitor of cardiac phospholipase D by a PIP2-dependent mechanism.
Topics: Animals; Biological Assay; Drug Interactions; Estrenes; Male; Membranes; Myocardium; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phospholipase D; Pyrrolidinones; Rats; Rats, Wistar; Signal Transduction; Type C Phospholipases | 2010 |
Ins(1,4,5)P3 interacts with PIP2 to regulate activation of TRPC6/C7 channels by diacylglycerol in native vascular myocytes.
Topics: Animals; Axons; Blotting, Western; Diglycerides; Electrophysiology; Estrenes; Immunoprecipitation; Inositol 1,4,5-Trisphosphate; Ion Channel Gating; Mesenteric Arteries; Myocytes, Smooth Muscle; Patch-Clamp Techniques; Phosphatidylinositol 4,5-Diphosphate; Phosphodiesterase Inhibitors; Portal Vein; Pyrrolidinones; Rabbits; TRPC Cation Channels | 2010 |
alpha-Adrenoceptor-mediated depletion of phosphatidylinositol 4, 5-bisphosphate inhibits activation of volume-regulated anion channels in mouse ventricular myocytes.
Topics: Adrenergic alpha-1 Receptor Agonists; Animals; Antibodies; Dioxanes; Estrenes; Male; Mice; Mice, Inbred C57BL; Myocytes, Cardiac; Phenylephrine; Phosphatidylinositol 4,5-Diphosphate; Prazosin; Pyrrolidinones; Receptors, Adrenergic, alpha; Voltage-Dependent Anion Channels | 2010 |
Spatial regulation of membrane fusion controlled by modification of phosphoinositides.
Topics: Animals; Cell Nucleus; Chromatin; Diglycerides; Endoplasmic Reticulum; Enzyme Inhibitors; Estrenes; Fluorescence Resonance Energy Transfer; GTP Phosphohydrolases; Guanosine Triphosphate; Lytechinus; Male; Membrane Fusion; Microscopy, Fluorescence; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Phospholipase C gamma; Pyrrolidinones | 2010 |
Stimulation of bursting in pre-Bötzinger neurons by Epac through calcium release and modulation of TRPM4 and K-ATP channels.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Androstadienes; Animals; Animals, Newborn; Biophysical Phenomena; Bradykinin; Brain Stem; Calcium; Cyclic AMP; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Estrenes; Excitatory Amino Acid Antagonists; Fluorescence Resonance Energy Transfer; In Vitro Techniques; KATP Channels; Membrane Potentials; Mice; Neurons; Patch-Clamp Techniques; Phosphatidylinositol 4,5-Diphosphate; Pyrrolidinones; TRPM Cation Channels; Wortmannin | 2011 |
Bradykinin acutely inhibits activity of the epithelial Na+ channel in mammalian aldosterone-sensitive distal nephron.
Topics: Absorption; Aldosterone; Animals; Biosensing Techniques; Bradykinin; Caffeine; Cyclic AMP; Dose-Response Relationship, Drug; Epithelial Sodium Channel Blockers; Epithelial Sodium Channels; Estrenes; GTP-Binding Protein alpha Subunits, Gq-G11; Hydrolysis; Ion Channel Gating; Kallidin; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Natriuresis; Nephrons; Patch-Clamp Techniques; Phosphatidylinositol 4,5-Diphosphate; Phosphodiesterase Inhibitors; Pyrrolidinones; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Signal Transduction; Sodium; Sodium Channel Blockers; Thapsigargin; Thionucleotides; Tissue Culture Techniques; Type C Phospholipases | 2011 |
Facilitation of sympathetic neurotransmission by phosphatidylinositol-4,5-bisphosphate-dependent regulation of KCNQ channels in rat mesenteric arteries.
Topics: Androstadienes; Animals; Bradykinin; Calcium; Calcium Channel Blockers; Electric Stimulation; Estrenes; Excitatory Postsynaptic Potentials; KCNQ Potassium Channels; Male; Membrane Potentials; Mesenteric Arteries; Microelectrodes; Neuromuscular Junction; omega-Conotoxin GVIA; Phosphatidylinositol 4,5-Diphosphate; Protein Kinase C; Pyrrolidinones; Rats; Rats, Wistar; Receptors, Purinergic; Sympathetic Nervous System; Synaptic Transmission; Type C Phospholipases; Wortmannin | 2012 |
Control of P2X3 channel function by metabotropic P2Y2 utp receptors in primary sensory neurons.
Topics: Adenosine Triphosphate; Animals; Cells, Cultured; Estrenes; Ganglia, Spinal; Male; Phosphatidylinositol 4,5-Diphosphate; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2X3; Receptors, Purinergic P2Y2; Sensory Receptor Cells; Type C Phospholipases; Uridine Triphosphate | 2013 |
Disassembly of Subplasmalemmal Actin Filaments Induces Cytosolic Ca2+ Increases in Astropecten aranciacus Eggs.
Topics: Actin Cytoskeleton; Animals; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cytochalasin B; Cytosol; Estrenes; Inositol 1,4,5-Trisphosphate Receptors; Microscopy, Confocal; Ovum; Phosphatidylinositol 4,5-Diphosphate; Phospholipase C gamma; Pyrrolidinones; src Homology Domains; Starfish; Thiazolidines | 2018 |