Page last updated: 2024-08-26

u 69593 and u-50488

u 69593 has been researched along with u-50488 in 85 studies

Research

Studies (85)

Timeframe	Studies, this research(%)	All Research%
pre-1990	10 (11.76)	18.7374
1990's	50 (58.82)	18.2507
2000's	15 (17.65)	29.6817
2010's	8 (9.41)	24.3611
2020's	2 (2.35)	2.80

Authors

Authors	Studies
Aldrich, JV; Caldwell, V; Choi, H; DeLander, GE; Murray, TF	1
Clark, CR; Halfpenny, PR; Hill, RG; Horwell, DC; Hughes, J; Jarvis, TC; Rees, DC; Schofield, D	1
Befort, K; Bloch, B; Charron, G; Gavériaux-Ruff, C; Kieffer, B; Lannes, B; Mattéi, MG; Matthes, H; Micheletti, G; Simonin, F	1
Akil, H; Goldstein, A; Mansour, A; Meng, F; Thompson, RC; Watson, SJ; Xie, GX	1
Chen, Y; Liu, J; Mestek, A; Yu, L	1
Bell, GI; Breder, CD; Kong, H; Raynor, K; Reisine, T; Takeda, J; Yasuda, K	1
Anzini, M; Cappelli, A; Clarke, GD; De Benedetti, PG; Mennuni, L; Menziani, MC; Sbacchi, M; Vomero, S	1
Adapa, ID; Auh, JS; Berzetei-Gurske, IP; Brandt, SR; Craymer, K; Farrington, L; Haggart, D; Kennedy, JM; O'Brien, A; Polgar, WE; Rodriguez, L; Schwartz, RW; Toll, L; White, A	1
Ferguson, DM; Larson, DL; Paterlini, MG; Portoghese, PS; Subramanian, G	1
Englberger, W; Geiger, C; Lehmkuhl, K; Schepmann, D; Wünsch, B; Zelenka, C	1
Fujii, H; Hirono, S; Nagase, H; Yamaotsu, N	1
Berzetei-Gurske, IP; Guerrieri, E; Schmidhammer, H; Spetea, M	1
Bourgeois, C; Schepmann, D; Werfel, E; Wünsch, B	1
Bourgeois, C; Christoph, T; Englberger, W; Galla, F; Galla, HJ; Hüwel, S; Kögel, B; Lehmkuhl, K; Schepmann, D; Soeberdt, M; Straßburger, W; Torres-Gómez, H; Werfel, E; Wünsch, B	1
Fujii, H; Hirayama, S; Iwai, T; Nagase, H; Nemoto, T; Wada, N	1
Dersch, CM; Iyer, MR; Jacobson, AE; Rice, KC; Rothman, RB	1
Avery, BA; Behnke, M; Chear, NJ; Hiranita, T; Kamble, SH; León, F; McCurdy, CR; McMahon, LR; Obeng, S; Patel, A; Ramanathan, S; Reeves, ME; Restrepo, LF; Sharma, A	1
Barlow, D; Benyhe, S; Chou, K; Della Valle, A; Houseknecht, K; Marinaccio, L; Masci, D; Minosi, P; Mollica, A; Pieretti, S; Scioli, G; Stefanucci, A; Streicher, JM; Szucs, E; Tanguturi, P	1
Gu, ZF; Jensen, RT; Maton, PN; Pradhan, T; Zhang, L	1
Finberg, RW; Heagy, W; Shipp, MA	1
Dziedzicka, M; Lasoń, W; Przewłocka, B; Przewłocki, R	1
Bansinath, M; Puig, MM; Ramabadran, K; Turndorf, H	5
Agbas, A; Ahmed, MS; Cemerikic, B; Cheng, J	1
Bhargava, HN; Gulati, A; Rahmani, NH	2
Bansinath, M; Ramabadran, K; Shukla, VK; Turndorf, H	1
Cheng, J; Pasternak, GW; Paul, D; Pick, CG	1
Adler, MW; Eisenstein, TK; Geller, EB; Rogers, TJ; Taub, DD	1
Caliezi, A; Drack, E; Halter, F; Scheurer, U; Varga, L; Wenger, F	1
Alzheimer, C; ten Bruggencate, G	1
Dickenson, AH; Sullivan, AF	1
Band, L; Bykov, V; de Costa, BR; Jacobson, AE; Pert, A; Rice, KC; Rothman, RB	1
Makimura, M; Murakoshi, Y	1
Bykov, V; De Costa, BR; France, CP; Jacobson, AE; Rice, KC; Rothman, RB; Woods, JH	1
Bianchi, G	1
Frey, HH	1
De Montis, GM; Devoto, P; Preti, A; Tagliamonte, A	1
Birch, PP; Cavicchini, E; Hayes, AG	1
Babovic-Vuksanovic, D; Heidbreder, CA; Shippenberg, TS; Shoaib, M	1
Privette, TH; Terrian, DM	1
Kuraishi, Y; Oyama, T; Satoh, M; Sugimoto, K; Ueda, M	1
Bansinath, M; Shukla, VK; Turndorf, H	1
Bidlack, JM; Joseph, DB; Lawrence, DM	1
Avidor-Reiss, T; Barg, J; Ezra, V; Levy, R; Matus-Leibovitch, N; Saya, D; Vogel, Z; Zippel, R	1
Bidlack, JM; Joseph, DB	1
Faden, AI; Fernyak, S; McIntosh, TK; Yamakami, I	1
Bell, GI; Benovic, J; Hines, J; Kong, G; Kong, H; Raynor, K; Reisine, T; Yasuda, K	1
Chen, C; DeRiel, JK; Kunapuli, S; Liu-Chen, LY; Xue, JC; Yu, L; Zhu, J	1
Bell, GI; Kong, H; Raynor, K; Reisine, T; Takeda, J; Yano, H	1
Sheng, JZ; Tai, KK; Wong, TM; Xia, Q	1
Headley, PM; Herrero, JF	1
Barg, J; Levy, R; Nah, SY; Saya, D; Vogel, Z	1
Childers, SR; Konkoy, CS	1
Chan, TK; Jin, WQ; Tai, KK; Wong, TM	1
Heidbreder, C; LeFevour, A; Shippenberg, TS	1
Flamigni, F; Giaccari, A; Muscari, C; Rossoni, C; Stanic, I; Stefanelli, C	1
Duncan, MJ; Elde, RP; Gurwell, JA; Hauser, KF; Maderspach, K; Stiene-Martin, A	1
Allard, M; Jordan, D; Kopp, N; Martin, D; Ries, C; Simonnet, G; Tafani, JA; Zajac, JM	1
Chavkin, C; Jin, W; Terman, GW	1
Blake, AD; Bot, G; Freeman, JC; Li, S; Reisine, T	1
Wang, HX; Wong, TM; Xia, Q; Zhang, WM	1
Fowler, CJ; Tiger, G	1
Mash, DC; Partilla, J; Rice, KC; Rothman, RB; Staley, JK	1
Holtzman, SG; Powell, KR	1
Madamba, SG; Schweitzer, P; Siggins, GR	1
De Vries, TJ; Schoffelmeer, AN; Vanderschuren, LJ; Wardeh, G	1
Hahn, B; Shoaib, M; Stolerman, IP	1
Eckert, WA; Light, AR; Willcockson, HH	1
Allen, CN; Grandy, DK; Ikeda, M; Nelson, CS; Shinagawa, H; Shinoe, T; Sugiyama, T; Yoshioka, T	1
Horie, S; Ishihara, S; Murayama, T; Tsuchiya, S; Watanabe, K	1
Bidlack, JM; Martin-Kleiner, I	1
Gullapalli, S; Ramarao, P	1
French, AM; Smith, MA	1
Jones, RM; Linsenmayer, DC; Mello, NK; Negus, SS; Portoghese, PS	1
Hanson, GR; Johnson-Davis, KL; Keefe, KA	1
Endoh, T; Fujimura, M; Izumimoto, N; Nagase, H; Suzuki, T; Takezawa, Y; Tanaka, T; Togashi, Y	1
Leitermann, RJ; Mizoguchi, H; Nagase, H; Narita, M; Suzuki, T; Tseng, LF	1
Juma, F; Kanui, TI; Maloiy, GM; Olongida Ole Miaron, J; Towett, PK	1
Baker, LE; Bell, LM; Haliw, LA; Killinger, BA; Panos, JJ; Peet, MM; Walker, SL	1
Kivell, B; Morani, AS; Prisinzano, TE; Schenk, S	1
Chefer, VI; Shippenberg, TS; Tejeda, HA; Zapata, A	1

Other Studies

85 other study(ies) available for u 69593 and u-50488

Article	Year
N-terminal alkylated derivatives of [D-Pro10]dynorphin A-(1-11) are highly selective for kappa-opioid receptors. Journal of medicinal chemistry, 1992, Nov-27, Volume: 35, Issue:24 Topics: Alkylation; Amino Acid Sequence; Animals; Cerebellum; Dynorphins; Guinea Pigs; Ileum; Molecular Sequence Data; Peptide Fragments; Receptors, Opioid, kappa	1992
Highly selective kappa opioid analgesics. Synthesis and structure-activity relationships of novel N-[(2-aminocyclohexyl)aryl]acetamide and N-[(2-aminocyclohexyl)aryloxy]acetamide derivatives. Journal of medicinal chemistry, 1988, Volume: 31, Issue:4 Topics: Acetamides; Analgesics; Animals; Binding, Competitive; Cyclohexylamines; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Models, Molecular; Narcotics; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship	1988
kappa-Opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system. Proceedings of the National Academy of Sciences of the United States of America, 1995, Jul-18, Volume: 92, Issue:15 Topics: Adenylyl Cyclases; Aged; Amino Acid Sequence; Base Sequence; Central Nervous System; Chromosome Mapping; Chromosomes, Human, Pair 8; Cloning, Molecular; DNA, Complementary; Exons; Genomic Library; Humans; In Situ Hybridization; Ligands; Middle Aged; Molecular Sequence Data; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins; RNA, Messenger; Sequence Homology, Amino Acid; Signal Transduction; Tissue Distribution	1995
Cloning and pharmacological characterization of a rat kappa opioid receptor. Proceedings of the National Academy of Sciences of the United States of America, 1993, Nov-01, Volume: 90, Issue:21 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Analgesics; Animals; Benzeneacetamides; Cell Line; Cell Membrane; Cloning, Molecular; Corpus Striatum; Cyclic AMP; DNA Primers; DNA, Complementary; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gene Library; In Situ Hybridization; Inositol 1,4,5-Trisphosphate; Kinetics; Ligands; Molecular Sequence Data; Pyrrolidines; Rats; Receptors, Opioid, kappa; Restriction Mapping; RNA, Messenger; Transfection	1993
Molecular cloning of a rat kappa opioid receptor reveals sequence similarities to the mu and delta opioid receptors. The Biochemical journal, 1993, Nov-01, Volume: 295 ( Pt 3) Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Benzomorphans; Cloning, Molecular; Diprenorphine; DNA, Complementary; Molecular Sequence Data; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sequence Analysis; Sequence Homology, Amino Acid; Transfection	1993
Cloning and functional comparison of kappa and delta opioid receptors from mouse brain. Proceedings of the National Academy of Sciences of the United States of America, 1993, Jul-15, Volume: 90, Issue:14 Topics: Amino Acid Sequence; Animals; Base Sequence; Brain Chemistry; Cloning, Molecular; In Situ Hybridization; Mice; Molecular Sequence Data; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Somatostatin; RNA, Messenger; Sequence Homology, Amino Acid; Substrate Specificity; Tissue Distribution	1993
Synthesis, biological evaluation, and quantitative receptor docking simulations of 2-[(acylamino)ethyl]-1,4-benzodiazepines as novel tifluadom-like ligands with high affinity and selectivity for kappa-opioid receptors. Journal of medicinal chemistry, 1996, Feb-16, Volume: 39, Issue:4 Topics: Amino Acid Sequence; Analgesics; Animals; Benzodiazepines; Binding, Competitive; Brain; Cerebral Cortex; Computer Graphics; Conserved Sequence; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Humans; Ligands; Mice; Models, Molecular; Molecular Sequence Data; Molecular Structure; Pancreas; Protein Conformation; Radioligand Assay; Rats; Receptors, Cholecystokinin; Receptors, Opioid, kappa; Sequence Homology, Amino Acid; Sincalide; Structure-Activity Relationship	1996
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications. NIDA research monograph, 1998, Volume: 178 Topics: Animals; Aorta, Thoracic; Cocaine; Cyclic AMP; Electric Stimulation; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Opioid-Related Disorders; Rats; Receptors, Dopamine; Receptors, Opioid; Receptors, Serotonin; Substance-Related Disorders	1998
Conformational analysis and automated receptor docking of selective arylacetamide-based kappa-opioid agonists. Journal of medicinal chemistry, 1998, Nov-19, Volume: 41, Issue:24 Topics: Acetamides; Binding Sites; Ligands; Models, Molecular; Molecular Conformation; Mutagenesis, Site-Directed; Receptors, Opioid, kappa; Structure-Activity Relationship	1998
Conformationally constrained kappa receptor agonists: stereoselective synthesis and pharmacological evaluation of 6,8-diazabicyclo[3.2.2]nonane derivatives. Journal of medicinal chemistry, 2010, May-27, Volume: 53, Issue:10 Topics: Animals; Azabicyclo Compounds; Cell Line; Guinea Pigs; Humans; In Vitro Techniques; Molecular Conformation; Radioligand Assay; Receptors, Opioid, kappa; Stereoisomerism; Structure-Activity Relationship	2010
Identification of the three-dimensional pharmacophore of kappa-opioid receptor agonists. Bioorganic & medicinal chemistry, 2010, Jun-15, Volume: 18, Issue:12 Topics: Models, Chemical; Models, Molecular; Receptors, Opioid, kappa	2010
Discovery and pharmacological evaluation of a diphenethylamine derivative (HS665), a highly potent and selective κ opioid receptor agonist. Journal of medicinal chemistry, 2012, Nov-26, Volume: 55, Issue:22 Topics: Acetic Acid; Analgesics; Animals; Drug Discovery; Mice; Nociception; Pain; Phenethylamines; Receptors, Opioid, kappa	2012
Combination of cyclohexane and piperazine based κ-opioid receptor agonists: Synthesis and pharmacological evaluation of trans,trans-configured perhydroquinoxalines. Bioorganic & medicinal chemistry, 2014, Jul-01, Volume: 22, Issue:13 Topics: Cyclohexanes; Dose-Response Relationship, Drug; Humans; Molecular Structure; Piperazine; Piperazines; Quinoxalines; Receptors, Opioid, kappa; Stereoisomerism; Structure-Activity Relationship	2014
Synthesis and pharmacological evaluation of 5-pyrrolidinylquinoxalines as a novel class of peripherally restricted κ-opioid receptor agonists. Journal of medicinal chemistry, 2014, Aug-14, Volume: 57, Issue:15 Topics: Analgesics, Opioid; Animals; Binding, Competitive; Blood-Brain Barrier; Brain; Endothelial Cells; Guinea Pigs; HEK293 Cells; Humans; Liver; Male; Mice; Models, Molecular; Pain Measurement; Permeability; Pyrrolidines; Quinoxalines; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma; Stereoisomerism; Structure-Activity Relationship	2014
Synthesis and Pharmacology of a Novel κ Opioid Receptor (KOR) Agonist with a 1,3,5-Trioxazatriquinane Skeleton. ACS medicinal chemistry letters, 2014, Aug-14, Volume: 5, Issue:8 Topics:	2014
Probes for narcotic receptor mediated phenomena 49. N-substituted rac-cis-4a-arylalkyl-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-6-ols. European journal of medicinal chemistry, 2015, Mar-06, Volume: 92 Topics: Benzofurans; Dose-Response Relationship, Drug; Heterocyclic Compounds, 3-Ring; Humans; Molecular Structure; Piperidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship	2015
Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. Journal of medicinal chemistry, 2020, 01-09, Volume: 63, Issue:1 Topics: Adrenergic Agents; Analgesics; Animals; Blood Proteins; CHO Cells; Cricetulus; Dopamine Agents; Guinea Pigs; Humans; Microsomes, Liver; Rats; Receptors, Adrenergic; Receptors, Opioid; Secologanin Tryptamine Alkaloids	2020
Discovery of κ Opioid Receptor (KOR)-Selective d-Tetrapeptides with Improved ACS medicinal chemistry letters, 2022, Nov-10, Volume: 13, Issue:11 Topics:	2022
Characterization of opioid receptors on smooth muscle cells from guinea pig stomach. The American journal of physiology, 1992, Volume: 262, Issue:3 Pt 1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gastric Mucosa; Guinea Pigs; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Naloxone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Stomach	1992
Opioid receptor agonists and Ca2+ modulation in human B cell lines. Journal of immunology (Baltimore, Md. : 1950), 1992, Dec-15, Volume: 149, Issue:12 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; B-Lymphocytes; Benzeneacetamides; Calcium; Cell Line; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Flow Cytometry; Humans; Naloxone; Pyrrolidines; Receptors, Opioid; Signal Transduction	1992
Differential effects of opioid receptor agonists on nociception and cAMP level in the spinal cord of monoarthritic rats. Life sciences, 1992, Volume: 50, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Arthritis; Benzeneacetamides; Colforsin; Cyclic AMP; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guanylyl Imidodiphosphate; Injections, Spinal; Male; Morphine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord	1992
Kappa-opiate agonist-induced inhibition of gastrointestinal transit in different strains of mice. Pharmacology, 1991, Volume: 42, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Gastrointestinal Transit; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Pyrroles; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Species Specificity; Thiophenes	1991
Opioids regulate the release of human chorionic gonadotropin hormone from trophoblast tissue. Life sciences, 1991, Volume: 49, Issue:11 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Benzeneacetamides; Chorionic Gonadotropin; Endorphins; Female; Humans; Morphine; Naltrexone; Placenta; Pregnancy; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Trophoblasts	1991
Effects of morphine tolerance-dependence and abstinence on kappa-opiate receptors of rat brain and spinal cord. Biochemical pharmacology, 1991, Aug-22, Volume: 42, Issue:6 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Body Temperature Regulation; Brain; Drug Tolerance; Ethylketocyclazocine; Male; Morphine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Spinal Cord; Substance-Related Disorders; Time Factors	1991
Intracerebroventricular administration of kappa-agonists induces convulsions in mice. Brain research bulletin, 1991, Volume: 27, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Baclofen; Benzeneacetamides; Benzomorphans; Cerebral Ventricles; Convulsants; Dizocilpine Maleate; Injections, Intraventricular; Ketamine; Mice; Mice, Inbred Strains; Muscimol; Naloxone; Narcotic Antagonists; Narcotics; Pyrroles; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Seizures; Stereoisomerism; Thiophenes	1991
Differential effects of two kappa-opiate agonists, U-50,488H and U-69,593, on the binding of 3H-(3-MeHis2) thyrotropin-releasing hormone to rat spinal cord and amygdala membranes. Pharmacology, 1991, Volume: 43, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amygdala; Analgesics; Animals; Benzeneacetamides; Binding, Competitive; Enkephalins; Male; Membranes; Pyrrolidines; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Thyrotropin-Releasing Hormone; Spinal Cord; Thyrotropin-Releasing Hormone	1991
Genetic influences in opioid analgesic sensitivity in mice. Brain research, 1991, Dec-06, Volume: 566, Issue:1-2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; Benzeneacetamides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mice; Mice, Inbred Strains; Morphine; Naloxone; Pain; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Species Specificity	1991
Immunomodulatory activity of mu- and kappa-selective opioid agonists. Proceedings of the National Academy of Sciences of the United States of America, 1991, Jan-15, Volume: 88, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Antibody Formation; Antibody-Producing Cells; Benzeneacetamides; Cells, Cultured; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Immunosuppression Therapy; Kinetics; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred Strains; Morphine; Naloxone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu	1991
Different motor actions of dynorphins and nonpeptide kappa opioid receptor agonists in the isolated rat colon. The Journal of pharmacology and experimental therapeutics, 1990, Volume: 252, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Antihypertensive Agents; Benzeneacetamides; Benzodiazepines; Benzomorphans; Colon; Diuretics; Dynorphins; Gastrointestinal Motility; In Vitro Techniques; Male; Muscle, Smooth; Naloxone; Narcotic Antagonists; Pressure; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa	1990
Nonopioid actions of the kappa-opioid receptor agonists, U 50488H and U 69593 on electrophysiologic properties of hippocampal CA3 neurons in vitro. The Journal of pharmacology and experimental therapeutics, 1990, Volume: 255, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzeneacetamides; Dynorphins; Guinea Pigs; Hippocampus; In Vitro Techniques; Membrane Potentials; Naloxone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa	1990
Electrophysiologic studies on the spinal antinociceptive action of kappa opioid agonists in the adult and 21-day-old rat. The Journal of pharmacology and experimental therapeutics, 1991, Volume: 256, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Aging; Analgesia; Analgesics; Animals; Anterior Horn Cells; Benzeneacetamides; Dose-Response Relationship, Drug; Electrophysiology; Formaldehyde; Injections, Spinal; Male; Pyrrolidines; Rats; Rats, Inbred Strains	1991
Probes for narcotic receptor mediated phenomena. 17. Synthesis and evaluation of a series of trans-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacet amide (U50,488) related isothiocyanate derivatives as opioid receptor affinity ligands. Journal of medicinal chemistry, 1990, Volume: 33, Issue:4 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzeneacetamides; Benzomorphans; Binding Sites; Brain; Chemical Phenomena; Chemistry; Cyclohexanes; Guinea Pigs; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Structure-Activity Relationship; Thiocyanates	1990
Effects of kappa- and mu-selective opiate agonists on colonic temperature in normoglycaemic and streptozotocin-treated hyperglycaemic mice. Pharmacology & toxicology, 1990, Volume: 66, Issue:5 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Body Temperature; Colon; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Fentanyl; Narcotics; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sufentanil	1990
Hyperglycemia does not modify the pupillary effects of mu and kappa opiate agonists in mice. Journal of ocular pharmacology, 1989,Spring, Volume: 5, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Blood Glucose; Fentanyl; Half-Life; Hyperglycemia; Male; Mice; Morphine; Narcotics; Pupil; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu	1989
Kappa-opioid agonists do not inhibit adenylate cyclase. Journal of pharmacobio-dynamics, 1989, Volume: 12, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclase Inhibitors; Animals; Benzeneacetamides; Benzomorphans; Binding, Competitive; Brain; Cell Membrane; Enkephalin, Methionine; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Levorphanol; Morphine; Naloxone; Pentazocine; Pyrrolidines; Rana catesbeiana; Receptors, Opioid; Receptors, Opioid, kappa; Sodium Chloride	1989
Pharmacological activities of optically pure enantiomers of the kappa opioid agonist, U50,488, and its cis diastereomer: evidence for three kappa receptor subtypes. European journal of pharmacology, 1989, Aug-29, Volume: 167, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Benzeneacetamides; Benzodiazepines; Benzomorphans; Binding, Competitive; Brain Chemistry; Cyclazocine; Discrimination, Psychological; Ethylketocyclazocine; Female; Guinea Pigs; Macaca mulatta; Male; Membranes; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Stereoisomerism	1989
High-performance liquid chromatographic assay of k-opioid selective benzeneacetamide derivatives (U50488, U69593 and PD117302) in rat plasma and brain. Journal of chromatography, 1989, Jul-21, Volume: 491, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzeneacetamides; Brain Chemistry; Chromatography, High Pressure Liquid; Male; Pyrroles; Pyrrolidines; Rats; Receptors, Opioid; Thiophenes	1989
Hyperglycaemia as a factor affecting kappa-opiate agonist-induced inhibition of the gastrointestinal transit in mice. The Journal of pharmacy and pharmacology, 1989, Volume: 41, Issue:7 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzeneacetamides; Blood Glucose; Charcoal; Diabetes Mellitus, Experimental; Gastrointestinal Transit; Hyperglycemia; Male; Mice; Narcotics; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa	1989
Effect of mu- and kappa-opioid agonists on the electroconvulsive seizure threshold in mice and antagonism by naloxone and MR 2266. Pharmacology & toxicology, 1988, Volume: 62, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Benzodiazepines; Benzomorphans; Electroshock; Fentanyl; Male; Mice; Morphinans; Morphine; Nalbuphine; Naloxone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Seizures	1988
Stereospecific inhibition of gastrointestinal transit by kappa opioid agonists in mice. European journal of pharmacology, 1988, Oct-18, Volume: 155, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Benzomorphans; Gastrointestinal Transit; Male; Mice; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Stereoisomerism	1988
Differential effect of mu, delta, and kappa opioid agonists on adenylate cyclase activity. Journal of neuroscience research, 1987, Volume: 17, Issue:4 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclases; Analgesics; Animals; Benzeneacetamides; Benzomorphans; Corpus Striatum; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Male; Morphinans; Peptide Fragments; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid	1987
Evidence that the kappa agonist U50488H has non-opioid actions. The Journal of pharmacy and pharmacology, 1988, Volume: 40, Issue:10 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzeneacetamides; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Muscle Contraction; Muscle, Smooth; Postural Balance; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa	1988
Development of behavioral sensitization to cocaine: influence of kappa opioid receptor agonists. The Journal of pharmacology and experimental therapeutics, 1995, Volume: 275, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Benzeneacetamides; Cocaine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Locomotion; Male; Nicotine; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Sensitivity and Specificity; Sodium Chloride	1995
Kappa opioid agonists produce anxiolytic-like behavior on the elevated plus-maze. Psychopharmacology, 1995, Volume: 118, Issue:4 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analysis of Variance; Animals; Anxiety; Behavior, Animal; Benzeneacetamides; Male; Maze Learning; Motor Activity; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa	1995
Opioidergic inhibition of capsaicin-evoked release of glutamate from rat spinal dorsal horn slices. Neuropharmacology, 1995, Volume: 34, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzeneacetamides; Capsaicin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glutamate Dehydrogenase; Glutamic Acid; In Vitro Techniques; Male; Morphine; Nerve Endings; Neurons, Afferent; Opioid Peptides; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord	1995
Pertussis and cholera toxins modulate kappa-opioid receptor agonists-induced hypothermia and gut inhibition. European journal of pharmacology, 1995, Mar-16, Volume: 292, Issue:3-4 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Anticonvulsants; Benzeneacetamides; Body Temperature; Cholera Toxin; Digestive System; Dose-Response Relationship, Drug; Gastrointestinal Transit; Injections, Intraventricular; Male; Mice; Pertussis Toxin; Pyrroles; Pyrrolidines; Receptors, Opioid, kappa; Thiophenes; Virulence Factors, Bordetella	1995
Kappa opioid receptors expressed on three related thymoma cell lines. Differences in receptor-effector coupling. Biochemical pharmacology, 1995, Jan-06, Volume: 49, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Analgesics; Animals; Benzeneacetamides; Benzomorphans; Cell Membrane; GTP Phosphohydrolases; Kinetics; Mice; Pyrrolidines; Receptors, Opioid, kappa; Thymoma; Thymus Neoplasms; Tumor Cells, Cultured	1995
kappa-Opioid receptor-transfected cell lines: modulation of adenylyl cyclase activity following acute and chronic opioid treatments. FEBS letters, 1995, Mar-13, Volume: 361, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Animals; Benzeneacetamides; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Etorphine; GTP-Binding Proteins; Naloxone; Naltrexone; Opioid Peptides; Pertussis Toxin; Pyrrolidines; Receptors, Opioid, kappa; Virulence Factors, Bordetella	1995
The kappa opioid receptor expressed on the mouse R1.1 thymoma cell line down-regulates without desensitizing during chronic opioid exposure. The Journal of pharmacology and experimental therapeutics, 1995, Volume: 272, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Benzeneacetamides; Cell Membrane; Down-Regulation; In Vitro Techniques; Mice; Naloxone; Naltrexone; Pertussis Toxin; Pyrrolidines; Receptors, Opioid, kappa; Thymoma; Tumor Cells, Cultured; Virulence Factors, Bordetella	1995
Central and systemic kappa-opioid agonists exacerbate neurobehavioral response to brain injury in rats. The American journal of physiology, 1994, Volume: 267, Issue:3 Pt 2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Animal; Benzeneacetamides; Brain; Brain Injuries; Cardiovascular System; Dynorphins; Injections, Intravenous; Injections, Intraventricular; Male; Movement Disorders; Nervous System; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Survival Analysis	1994
Molecular mechanisms of agonist-induced desensitization of the cloned mouse kappa opioid receptor. The Journal of pharmacology and experimental therapeutics, 1994, Volume: 270, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzeneacetamides; beta-Adrenergic Receptor Kinases; Cattle; Cell Line; Cloning, Molecular; Cyclic AMP-Dependent Protein Kinases; Drug Tolerance; Mice; Pyrrolidines; Receptors, Opioid, kappa; Recombinant Proteins	1994
Differential binding domains of peptide and non-peptide ligands in the cloned rat kappa opioid receptor. The Journal of biological chemistry, 1994, Dec-02, Volume: 269, Issue:48 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Animals; Base Sequence; Benzeneacetamides; Binding Sites; Binding, Competitive; Cell Line; Chlorocebus aethiops; Cloning, Molecular; Diprenorphine; DNA Primers; Dynorphins; Endorphins; Kinetics; Ligands; Molecular Sequence Data; Naltrexone; Polymerase Chain Reaction; Protein Conformation; Protein Structure, Secondary; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Fusion Proteins; Transfection	1994
Agonists and antagonists bind to different domains of the cloned kappa opioid receptor. Proceedings of the National Academy of Sciences of the United States of America, 1994, Aug-16, Volume: 91, Issue:17 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Base Sequence; Benzeneacetamides; Binding Sites; Cell Line; Chlorocebus aethiops; Cloning, Molecular; Colforsin; Cyclic AMP; Enkephalin, Leucine; Kinetics; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Naloxone; Naltrexone; Oligodeoxyribonucleotides; Protein Structure, Secondary; Pyrrolidines; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Recombinant Fusion Proteins; Recombinant Proteins; Transfection	1994
Effects of chronic U50,488H treatment on binding and mechanical responses of the rat hearts. The Journal of pharmacology and experimental therapeutics, 1994, Volume: 268, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzeneacetamides; Heart; Heart Rate; In Vitro Techniques; Male; Myocardial Contraction; Myocardium; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa	1994
Functional evidence for multiple receptor activation by kappa-ligands in the inhibition of spinal nociceptive reflexes in the rat. British journal of pharmacology, 1993, Volume: 110, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Anticonvulsants; Benzeneacetamides; Benzofurans; Blood Pressure; Decerebrate State; Male; Naloxone; Nociceptors; Piperazines; Pyrroles; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Reflex; Spinal Cord; Thiophenes	1993
Modulation of thymidine incorporation by kappa-opioid ligands in rat spinal cord-dorsal root ganglion co-cultures. Brain research, 1993, Nov-26, Volume: 629, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzeneacetamides; Benzomorphans; Cell Communication; Cells, Cultured; Cytosol; DNA; Dose-Response Relationship, Drug; Embryo, Mammalian; Ganglia, Spinal; Inositol Phosphates; Kinetics; Lithium Chloride; Neurons; Pertussis Toxin; Pyrrolidines; Rats; Receptors, Opioid, kappa; Spinal Cord; Thymidine; Time Factors; Tritium; Virulence Factors, Bordetella	1993
Relationship between kappa 1 opioid receptor binding and inhibition of adenylyl cyclase in guinea pig brain membranes. Biochemical pharmacology, 1993, Jan-07, Volume: 45, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclase Inhibitors; Animals; Benzeneacetamides; Binding Sites; Cerebellum; Dose-Response Relationship, Drug; Guinea Pigs; Hippocampus; Naltrexone; Pyrrolidines; Receptors, Opioid, kappa	1993
Further characterization of [3H]U69593 binding sites in the rat heart. Journal of molecular and cellular cardiology, 1995, Volume: 27, Issue:8 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzeneacetamides; Binding Sites; Brain; Etorphine; Female; Kinetics; Myocardium; Organ Specificity; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Tritium	1995
kappa-Opioid receptor agonists prevent sensitization to the conditioned rewarding effects of cocaine. The Journal of pharmacology and experimental therapeutics, 1996, Volume: 276, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Cocaine; Conditioning, Psychological; Dopamine; Male; Naltrexone; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reward	1996
Inhibition of the expression of ornithine decarboxylase by some kappa-opioidergic receptor ligands in difluoromethylornithine-resistant L1210 cells. Biochimica et biophysica acta, 1996, May-28, Volume: 1311, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Base Sequence; Benzeneacetamides; Cell Division; DNA Primers; Drug Resistance; Eflornithine; Enzyme Induction; Enzyme Inhibitors; Leukemia L1210; Lymphocytes; Mice; Molecular Sequence Data; Narcotic Antagonists; Narcotics; Ornithine Decarboxylase; Pyrrolidines; Receptors, Opioid, kappa; RNA, Messenger; Stereoisomerism; Tumor Cells, Cultured	1996
kappa-opioid receptor expression defines a phenotypically distinct subpopulation of astroglia: relationship to Ca2+ mobilization, development, and the antiproliferative effect of opioids. Brain research, 1996, Oct-21, Volume: 737, Issue:1-2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Astrocytes; Benzeneacetamides; Bromodeoxyuridine; Calcium; Calcium Channel Blockers; Cell Count; Cell Division; Cells, Cultured; DNA; Enzyme Inhibitors; Gene Expression Regulation, Developmental; Immunohistochemistry; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Nifedipine; Phenotype; Pyrrolidines; Receptors, Opioid, kappa; Thapsigargin; Time Factors	1996
Evidence for multiple opioid receptors in the human posterior pituitary. Journal of neuroendocrinology, 1996, Volume: 8, Issue:11 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adult; Benzeneacetamides; Binding Sites; Binding, Competitive; Cadaver; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Humans; Male; Middle Aged; Narcotics; Oligopeptides; Pituitary Gland, Posterior; Pyrrolidines; Receptors, Opioid; Tissue Distribution	1996
Kappa opioid receptor tolerance in the guinea pig hippocampus. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 281, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Dizocilpine Maleate; Drug Tolerance; Guinea Pigs; Hippocampus; In Vitro Techniques; Male; Pyrrolidines; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa; Receptors, Opioid, mu	1997
Differential agonist regulation of the human kappa-opioid receptor. Journal of neurochemistry, 1997, Volume: 68, Issue:5 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylate Cyclase Toxin; Benzeneacetamides; Cell Line; Cyclic AMP; Diprenorphine; Dynorphins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Levorphanol; Narcotic Antagonists; Narcotics; Pertussis Toxin; Pyrrolidines; Receptors, Opioid, kappa; Virulence Factors, Bordetella	1997
Inhibition of [3H]-U69593 binding and the cardiac effects of U50, 488H by calcium channel blockers in the rat heart. British journal of pharmacology, 1997, Volume: 120, Issue:5 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Antihypertensive Agents; Benzeneacetamides; Calcium; Calcium Channel Blockers; Heart; In Vitro Techniques; Male; Nifedipine; Protein Binding; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Tritium; Verapamil	1997
Comparison of the effects of a series of kappa-opioid receptor agonists upon sodium channel function in rat brain miniprisms. Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology, 1997, Volume: 117, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzeneacetamides; Benzomorphans; Brain; Disease Models, Animal; Inositol Phosphates; Naloxone; Pyrrolidines; Rats; Receptors, Opioid, kappa; Sodium Channels	1997
Kappa2 opioid receptors in limbic areas of the human brain are upregulated by cocaine in fatal overdose victims. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997, Nov-01, Volume: 17, Issue:21 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adult; Amygdala; Benzeneacetamides; Benzomorphans; Binding, Competitive; Brain; Brain Chemistry; Caudate Nucleus; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Drug Overdose; Female; Fentanyl; Gyrus Cinguli; Humans; Isothiocyanates; Kinetics; Male; Morphinans; Protein Binding; Pyrrolidines; Receptors, Opioid, kappa; Tissue Distribution; Up-Regulation	1997
Differential antagonism of the rate-decreasing effects of kappa-opioid receptor agonists by naltrexone and norbinaltorphimine. European journal of pharmacology, 1999, Jul-14, Volume: 377, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Benzeneacetamides; Benzofurans; Benzomorphans; Conditioning, Operant; Dose-Response Relationship, Drug; Ethylketocyclazocine; Nalorphine; Naltrexone; Narcotic Antagonists; Pyrroles; Pyrrolidines; Receptors, Opioid, kappa; Reinforcement Schedule; Saimiri; Thiophenes	1999
Dynorphin selectively augments the M-current in hippocampal CA1 neurons by an opiate receptor mechanism. Journal of neurophysiology, 1999, Volume: 82, Issue:4 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Hippocampus; In Vitro Techniques; Oligopeptides; Peptide Fragments; Potassium Channels; Pyramidal Cells; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa	1999
Dissociable effects of the kappa-opioid receptor agonists bremazocine, U69593, and U50488H on locomotor activity and long-term behavioral sensitization induced by amphetamine and cocaine. Psychopharmacology, 2000, Volume: 150, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amphetamine; Analgesics; Animals; Benzeneacetamides; Benzomorphans; Central Nervous System Stimulants; Cocaine; Male; Motor Activity; Psychomotor Agitation; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa	2000
Kappa-opioid receptor modulation of nicotine-induced behaviour. Neuropharmacology, 2000, Volume: 39, Issue:13 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Animal; Benzeneacetamides; Benzofurans; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Motor Activity; Naltrexone; Nicotine; Nicotinic Agonists; Pyrrolidines; Rats; Receptors, Opioid, kappa	2000
Interference of biocytin with opioid-evoked hyperpolarization and membrane properties of rat spinal substantia gelatinosa neurons. Neuroscience letters, 2001, Jan-12, Volume: 297, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Benzeneacetamides; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Lysine; Membrane Potentials; Organ Culture Techniques; Patch-Clamp Techniques; Pyrrolidines; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Substantia Gelatinosa	2001
Cyclic AMP regulates the calcium transients released from IP(3)-sensitive stores by activation of rat kappa-opioid receptors expressed in CHO cells. Cell calcium, 2001, Volume: 29, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 8-Bromo Cyclic Adenosine Monophosphate; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Benzeneacetamides; Bucladesine; Calcium; Calcium Signaling; CHO Cells; Cloning, Molecular; Colforsin; Cricetinae; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enzyme Inhibitors; Gene Expression; Inositol 1,4,5-Trisphosphate; Peptides; Pyrrolidines; Rats; Receptors, Opioid, kappa; Thionucleotides; Transfection	2001
Stimulatory effects of centrally injected kappa-opioid receptor agonists on gastric acid secretion in urethane-anesthetized rats. European journal of pharmacology, 2001, Apr-27, Volume: 418, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Anesthesia; Anesthetics, Intravenous; Animals; Benzeneacetamides; Deoxyglucose; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Gastric Acid; Gastric Mucosa; Injections, Intraventricular; Male; Morphine; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stomach; Time Factors; Urethane; Vagus Nerve	2001
Chronic opioid treatment of the mouse thymoma cell lines R1.G1 and R1EGO leads to down-regulation of the kappa opioid receptor without desensitization of adenylyl cyclase activity. International immunopharmacology, 2001, Volume: 1, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Benzeneacetamides; Down-Regulation; Enzyme Inhibitors; Kinetics; Mice; Pyrrolidines; Receptors, Opioid, kappa; Thymoma; Thymus Neoplasms; Tumor Cells, Cultured	2001
L-type Ca2+ channel modulation by dihydropyridines potentiates kappa-opioid receptor agonist induced acute analgesia and inhibits development of tolerance in rats. Neuropharmacology, 2002, Volume: 42, Issue:4 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Benzeneacetamides; Calcium Channels, L-Type; Cannabinoids; Dihydropyridines; Dose-Response Relationship, Drug; Drug Synergism; Drug Tolerance; Male; Pyrroles; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Thiophenes	2002
Age-related differences in sensitivity to the antinociceptive effects of kappa opioids in adult male rats. Psychopharmacology, 2002, Volume: 162, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Age Factors; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Analysis of Variance; Animals; Benzeneacetamides; Butorphanol; Cold Temperature; Dose-Response Relationship, Drug; Drug Synergism; Male; Nalbuphine; Pain; Pain Measurement; Pyrrolidines; Rats; Rats, Inbred F344; Reaction Time; Receptors, Opioid, kappa	2002
Kappa opioid antagonist effects of the novel kappa antagonist 5'-guanidinonaltrindole (GNTI) in an assay of schedule-controlled behavior in rhesus monkeys. Psychopharmacology, 2002, Volume: 163, Issue:3-4 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Animals; Benzamides; Benzeneacetamides; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Female; Guanidines; Macaca mulatta; Male; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Piperazines; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Reinforcement Schedule; Time Factors	2002
Lack of effect of kappa-opioid receptor agonism on long-term methamphetamine-induced neurotoxicity in rats. Neurotoxicity research, 2003, Volume: 5, Issue:4 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amphetamine-Related Disorders; Analgesics; Analgesics, Non-Narcotic; Animals; Benzeneacetamides; Brain Chemistry; Central Nervous System Stimulants; Dopamine; Male; Methamphetamine; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Serotonin	2003
Effect of repeated administration of TRK-820, a kappa-opioid receptor agonist, on tolerance to its antinociceptive and sedative actions. Brain research, 2004, Jan-09, Volume: 995, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzeneacetamides; Drug Tolerance; Male; Mice; Morphinans; Morphine; Motor Activity; Pain Measurement; Pyrrolidines; Receptors, Opioid, kappa; Spiro Compounds	2004
Region-dependent G-protein activation by kappa-opioid receptor agonists in the mouse brain. Neuroscience letters, 2004, Feb-12, Volume: 356, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Brain; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Morphinans; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, kappa; Spiro Compounds	2004
Activation of micro, delta or kappa opioid receptors by DAMGO, DPDPE, U-50488 or U-69593 respectively causes antinociception in the formalin test in the naked mole-rat (Heterocephalus glaber). Pharmacology, biochemistry, and behavior, 2009, Volume: 91, Issue:4 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Benzeneacetamides; Data Interpretation, Statistical; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Formaldehyde; Injections, Intraperitoneal; Male; Mole Rats; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Pyrrolidines; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu	2009
Comparison of the discriminative stimulus effects of salvinorin A and its derivatives to U69,593 and U50,488 in rats. Psychopharmacology, 2009, Volume: 203, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Animal; Benzeneacetamides; Discrimination, Psychological; Diterpenes, Clerodane; Dose-Response Relationship, Drug; Hallucinogens; Male; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Salvia	2009
Effect of kappa-opioid receptor agonists U69593, U50488H, spiradoline and salvinorin A on cocaine-induced drug-seeking in rats. Pharmacology, biochemistry, and behavior, 2009, Volume: 94, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Addictive; Benzeneacetamides; Cocaine; Diterpenes, Clerodane; Male; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Self Administration	2009
The effects of kappa-opioid receptor ligands on prepulse inhibition and CRF-induced prepulse inhibition deficits in the rat. Psychopharmacology, 2010, Volume: 210, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Corticotropin-Releasing Hormone; Diterpenes, Clerodane; Dose-Response Relationship, Drug; Ligands; Male; Naltrexone; Neural Inhibition; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reflex, Startle	2010