Compounds > u 69593
Page last updated: 2024-08-26

u 69593 and norbinaltorphimine

u 69593 has been researched along with norbinaltorphimine in 72 studies

Research

Studies (72)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's42 (58.33)18.2507
2000's14 (19.44)29.6817
2010's16 (22.22)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Befort, K; Bloch, B; Charron, G; Gavériaux-Ruff, C; Kieffer, B; Lannes, B; Mattéi, MG; Matthes, H; Micheletti, G; Simonin, F1
Akil, H; Goldstein, A; Mansour, A; Meng, F; Thompson, RC; Watson, SJ; Xie, GX1
Chen, Y; Liu, J; Mestek, A; Yu, L1
Bell, GI; Breder, CD; Kong, H; Raynor, K; Reisine, T; Takeda, J; Yasuda, K1
Adapa, ID; Auh, JS; Berzetei-Gurske, IP; Brandt, SR; Craymer, K; Farrington, L; Haggart, D; Kennedy, JM; O'Brien, A; Polgar, WE; Rodriguez, L; Schwartz, RW; Toll, L; White, A1
Grundt, P; Husbands, SM; Jales, AR; Lewis, JW; Traynor, JR1
Englberger, W; Geiger, C; Lehmkuhl, K; Schepmann, D; Wünsch, B; Zelenka, C1
Aubé, J; Bohn, LM; Frankowski, KJ; Lovell, KM; Phillips, AM; Prisinzano, TE; Schoenen, FJ; Slauson, SR; Streicher, JM; Whipple, DA; Zhou, L1
Horan, P; Porreca, F; Taylor, J; Yamamura, HI1
Caudle, RM; Chavkin, C; Wagner, JJ1
Herz, A; Shippenberg, TS; Spanagel, R1
Cometta-Morini, C; Kamal, J; Loew, G; Maguire, P; Tsai, N; Upton, C1
Agbas, A; Ahmed, MS; Cemerikic, B; Cheng, J1
Kromer, W1
Fukuda, K; Fukushima, N; Misu, Y; Miyamae, T; Sasaki, Y; Takeshima, H; Ueda, H1
Chavkin, C; Davidson, N; Grandy, DK; Henry, DJ; Lester, HA1
Kuznetsov, A; Ma, GH; Miller, RJ; Philipson, LH1
Almeida, OF; Shippenberg, TS; Spanagel, R1
Avidor-Reiss, T; Barg, J; Ezra, V; Levy, R; Matus-Leibovitch, N; Saya, D; Vogel, Z; Zippel, R1
Lasoń, W; Machelska, H; Przewłocka, B1
Grudt, TJ; Williams, JT1
Chavkin, C; Terman, GW; Wagner, JJ2
Chen, C; DeRiel, JK; Kunapuli, S; Liu-Chen, LY; Xue, JC; Yu, L; Zhu, J1
Kavaliers, M; Saucier, DM1
Mulder, AH; Ronken, E; Schoffelmeer, AN1
Holtzman, SG; Paronis, CA; Waddell, AB1
Barg, J; Belcheva, MM; Coscia, CJ; Rowiński, J1
Heidbreder, C; LeFevour, A; Shippenberg, TS1
Feng, J; Kendig, JJ1
Duncan, MJ; Elde, RP; Gurwell, JA; Hauser, KF; Maderspach, K; Stiene-Martin, A1
Ho, IK; Hoshi, K; Ma, T; Oh, S1
McGinty, JF; Rawls, SM1
Miller, RJ; Simen, AA1
Ahmed, MS; Cemerikic, B; Zamah, R1
Catheline, G; Guilbaud, G; Kayser, V1
Foxx-Orenstein, AE; Grider, JR; Jin, JG1
Akil, H; Clark, MJ; Mansour, A; Medzihradsky, F; Remmers, AE; Woods, JH1
Minami, M; Nakagawa, T; Ozawa, T; Satoh, M; Watanabe, T1
Besson, JM; Catheline, G; Le Guen, S1
Minami, M; Nakagawa, T; Ozawa, T; Satoh, M1
Dalman, FC; O'Malley, KL1
Holtzman, SG; Powell, KR1
Gray, AM; McGinty, JF; Rawls, SM; Shippenberg, TS1
Heyliger, SO; Jackson, C; Rice, KC; Rothman, RB1
Cheong, YP; Cho, KP; Kim, CJ; Kim, JK; Kim, KW; Kwun, J; Woo, RS1
Hahn, B; Shoaib, M; Stolerman, IP1
Justice, JB; Sharpe, LG; Shippenberg, TS; Thompson, AC; Vaughan, RA; Zapata, A1
Dermitzaki, E; Gravanis, A; Margioris, AN; Stournaras, C; Venihaki, M1
Binder, W; Junien, JL; Machelska, H; Mousa, S; Rivière, PJ; Schäfer, M; Schmitt, T; Stein, C1
Butelman, ER; Ko, MC; Kreek, MJ; Traynor, JR; Vivian, JA; Woods, JH1
Jones, RM; Linsenmayer, DC; Mello, NK; Negus, SS; Portoghese, PS1
Craft, RM; McNiel, DM1
Bonci, A; Fields, HL; Hjelmstad, GO; Margolis, EB1
Leitermann, RJ; Mizoguchi, H; Nagase, H; Narita, M; Suzuki, T; Tseng, LF1
Fantegrossi, WE; Koreeda, M; Kugle, KM; Valdes, LJ; Woods, JH1
Chefer, VI; Shippenberg, TS1
Kaminski, RM; Shippenberg, TS; Witkin, JM1
Belcheva, MM; Coscia, CJ; Ezerskiy, LA; Hahn, JW; He, J; Jagwani, S; Kim, E; Rendell, VR; Wesselschmidt, R1
Cheng, K; Morrissey, EM; Negus, SS; Rice, KC; Rosenberg, M1
Chefer, VI; Shippenberg, TS; Tejeda, HA; Zapata, A1
Hentges, ST; Pennock, RL1
McDermott, CM; Schrader, LA1
Bäckman, CM; Chefer, V; Counotte, DS; O'Donnell, P; Oh, E; Ramamoorthy, S; Schultz-Kuszak, KN; Shippenberg, TS; Tejeda, HA1
Ganno, ML; McLaughlin, JP; Patkar, KA; Rasakham, K; Ross, NC; Singh, HD; Toll, L; Wu, J1
Banks, ML; Bowers, MS; Carlezon, WA; Cheng, K; Leitl, MD; Negus, SS; Onvani, S; Rice, KC1
Gilpin, NW; Koob, GF; Roberto, M; Schweitzer, P1
Aldrich, JV; Cowan, A; Dimattio, KM; Liu-Chen, LY; Yakovleva, TV1
Chang, XM; Fang, Q; Han, ZL; Li, N; Li, XH; Pan, JX; Tang, HH; Wang, P; Wang, R; Wang, ZL; Zheng, T1
Hanks, AN; Hughes, ZA; Mejias-Aponte, C; O'Donnell, P; Scott, L; Tejeda, HA1
Diaz, MR; Przybysz, KR; Werner, DF1
Bertoglio, LJ; Bicca, MA; Giachero, M; Linartevichi, VF; Monteiro de Lima, TC; Vanz, F1

Other Studies

72 other study(ies) available for u 69593 and norbinaltorphimine

ArticleYear
kappa-Opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system.
    Proceedings of the National Academy of Sciences of the United States of America, 1995, Jul-18, Volume: 92, Issue:15

    Topics: Adenylyl Cyclases; Aged; Amino Acid Sequence; Base Sequence; Central Nervous System; Chromosome Mapping; Chromosomes, Human, Pair 8; Cloning, Molecular; DNA, Complementary; Exons; Genomic Library; Humans; In Situ Hybridization; Ligands; Middle Aged; Molecular Sequence Data; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins; RNA, Messenger; Sequence Homology, Amino Acid; Signal Transduction; Tissue Distribution

1995
Cloning and pharmacological characterization of a rat kappa opioid receptor.
    Proceedings of the National Academy of Sciences of the United States of America, 1993, Nov-01, Volume: 90, Issue:21

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Analgesics; Animals; Benzeneacetamides; Cell Line; Cell Membrane; Cloning, Molecular; Corpus Striatum; Cyclic AMP; DNA Primers; DNA, Complementary; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gene Library; In Situ Hybridization; Inositol 1,4,5-Trisphosphate; Kinetics; Ligands; Molecular Sequence Data; Pyrrolidines; Rats; Receptors, Opioid, kappa; Restriction Mapping; RNA, Messenger; Transfection

1993
Molecular cloning of a rat kappa opioid receptor reveals sequence similarities to the mu and delta opioid receptors.
    The Biochemical journal, 1993, Nov-01, Volume: 295 ( Pt 3)

    Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Benzomorphans; Cloning, Molecular; Diprenorphine; DNA, Complementary; Molecular Sequence Data; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sequence Analysis; Sequence Homology, Amino Acid; Transfection

1993
Cloning and functional comparison of kappa and delta opioid receptors from mouse brain.
    Proceedings of the National Academy of Sciences of the United States of America, 1993, Jul-15, Volume: 90, Issue:14

    Topics: Amino Acid Sequence; Animals; Base Sequence; Brain Chemistry; Cloning, Molecular; In Situ Hybridization; Mice; Molecular Sequence Data; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Somatostatin; RNA, Messenger; Sequence Homology, Amino Acid; Substrate Specificity; Tissue Distribution

1993
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.
    NIDA research monograph, 1998, Volume: 178

    Topics: Animals; Aorta, Thoracic; Cocaine; Cyclic AMP; Electric Stimulation; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Opioid-Related Disorders; Rats; Receptors, Dopamine; Receptors, Opioid; Receptors, Serotonin; Substance-Related Disorders

1998
14-amino, 14-alkylamino, and 14-acylamino analogs of oxymorphindole. Differential effects on opioid receptor binding and functional profiles.
    Journal of medicinal chemistry, 2003, Apr-10, Volume: 46, Issue:8

    Topics: Analgesics, Opioid; Animals; Binding, Competitive; CHO Cells; Cricetinae; Morpholines; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship

2003
Conformationally constrained kappa receptor agonists: stereoselective synthesis and pharmacological evaluation of 6,8-diazabicyclo[3.2.2]nonane derivatives.
    Journal of medicinal chemistry, 2010, May-27, Volume: 53, Issue:10

    Topics: Animals; Azabicyclo Compounds; Cell Line; Guinea Pigs; Humans; In Vitro Techniques; Molecular Conformation; Radioligand Assay; Receptors, Opioid, kappa; Stereoisomerism; Structure-Activity Relationship

2010
Potency enhancement of the κ-opioid receptor antagonist probe ML140 through sulfonamide constraint utilizing a tetrahydroisoquinoline motif.
    Bioorganic & medicinal chemistry, 2015, Jul-15, Volume: 23, Issue:14

    Topics: Animals; Arrestins; Benzamides; beta-Arrestins; Chemistry Techniques, Synthetic; CHO Cells; Cricetulus; Drug Evaluation, Preclinical; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa; Structure-Activity Relationship; Sulfonamides; Tetrahydroisoquinolines

2015
Extremely long-lasting antagonistic actions of nor-binaltorphimine (nor-BNI) in the mouse tail-flick test.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 260, Issue:3

    Topics: Age Factors; Animals; Benzeneacetamides; Benzomorphans; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Time Factors

1992
Kappa-opioids decrease excitatory transmission in the dentate gyrus of the guinea pig hippocampus.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1992, Volume: 12, Issue:1

    Topics: Action Potentials; Animals; Benzeneacetamides; Diprenorphine; Dynorphins; Electrophysiology; Endorphins; Guinea Pigs; Hippocampus; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Synapses

1992
Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway.
    Proceedings of the National Academy of Sciences of the United States of America, 1992, Mar-15, Volume: 89, Issue:6

    Topics: Analgesics; Animals; Benzeneacetamides; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Infusions, Parenteral; Limbic System; Male; Microinjections; Models, Neurological; Naltrexone; Nucleus Accumbens; Pyrrolidines; Rats; Rats, Inbred Strains; Somatostatin; Tegmentum Mesencephali

1992
Pharmacological profiles of fentanyl analogs at mu, delta and kappa opiate receptors.
    European journal of pharmacology, 1992, Mar-24, Volume: 213, Issue:2

    Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Guinea Pigs; Ileum; Male; Mice; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens

1992
Opioids regulate the release of human chorionic gonadotropin hormone from trophoblast tissue.
    Life sciences, 1991, Volume: 49, Issue:11

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Benzeneacetamides; Chorionic Gonadotropin; Endorphins; Female; Humans; Morphine; Naltrexone; Placenta; Pregnancy; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Trophoblasts

1991
Voltage-clamp experiments reveal receptor type-dependent modulation of chloride secretion in the guinea pig colonic mucosa by intestinal opioids.
    Naunyn-Schmiedeberg's archives of pharmacology, 1991, Volume: 344, Issue:3

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alprostadil; Amiloride; Amino Acid Sequence; Analgesics; Animals; Benzeneacetamides; Chlorides; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Gluconates; Guinea Pigs; Intestinal Mucosa; Male; Membrane Potentials; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin; Tetrodotoxin; Theophylline

1991
Opioid mu- and kappa-receptor mediate phospholipase C activation through Gi1 in Xenopus oocytes.
    Brain research. Molecular brain research, 1995, Volume: 32, Issue:1

    Topics: Animals; Benzeneacetamides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Activation; Female; GTP-Binding Proteins; Naltrexone; Oocytes; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Type C Phospholipases; Xenopus laevis

1995
Kappa-opioid receptors couple to inwardly rectifying potassium channels when coexpressed by Xenopus oocytes.
    Molecular pharmacology, 1995, Volume: 47, Issue:3

    Topics: Amino Acid Sequence; Animals; Base Sequence; Benzeneacetamides; Binding Sites; Cloning, Molecular; Electrophysiology; Female; GTP-Binding Proteins; Ion Channel Gating; Molecular Sequence Data; Naltrexone; Oocytes; Potassium Channels; Pyrrolidines; Rats; Receptors, Opioid, kappa; RNA, Complementary; Xenopus

1995
kappa-Opioid receptor activates an inwardly rectifying K+ channel by a G protein-linked mechanism: coexpression in Xenopus oocytes.
    Molecular pharmacology, 1995, Volume: 47, Issue:5

    Topics: Animals; Benzeneacetamides; Cloning, Molecular; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Gene Expression; GTP-Binding Proteins; In Vitro Techniques; Mice; Naloxone; Naltrexone; Oocytes; Pertussis Toxin; Potassium Channels; Pyrrolidines; Receptors, Opioid, kappa; RNA, Complementary; Virulence Factors, Bordetella; Xenopus

1995
Evidence that nor-binaltorphimine can function as an antagonist at multiple opioid receptor subtypes.
    European journal of pharmacology, 1994, Oct-24, Volume: 264, Issue:2

    Topics: Amino Acid Sequence; Analgesics; Animals; Benzeneacetamides; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Injections, Intraventricular; Male; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Pain; Pain Threshold; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Somatostatin

1994
kappa-Opioid receptor-transfected cell lines: modulation of adenylyl cyclase activity following acute and chronic opioid treatments.
    FEBS letters, 1995, Mar-13, Volume: 361, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Animals; Benzeneacetamides; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Etorphine; GTP-Binding Proteins; Naloxone; Naltrexone; Opioid Peptides; Pertussis Toxin; Pyrrolidines; Receptors, Opioid, kappa; Virulence Factors, Bordetella

1995
Kappa opioid receptor agonists inhibit the pilocarpine-induced seizures and toxicity in the mouse.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 1994, Volume: 4, Issue:4

    Topics: Analgesics; Animals; Benzeneacetamides; Brain; Injections, Intraperitoneal; Mice; Naltrexone; Pilocarpine; Pyrroles; Pyrrolidines; Receptors, Opioid, kappa; Seizures; Thiophenes

1994
kappa-Opioid receptors also increase potassium conductance.
    Proceedings of the National Academy of Sciences of the United States of America, 1993, Dec-01, Volume: 90, Issue:23

    Topics: Animals; Benzeneacetamides; Dynorphins; Electric Conductivity; Guinea Pigs; In Vitro Techniques; Ion Channel Gating; Male; Membrane Potentials; Naltrexone; Potassium Channels; Pyrrolidines; Receptors, Opioid, kappa; Trigeminal Nuclei

1993
Kappa opioids inhibit induction of long-term potentiation in the dentate gyrus of the guinea pig hippocampus.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1994, Volume: 14, Issue:8

    Topics: Animals; Benzeneacetamides; Dynorphins; Electric Stimulation; Guinea Pigs; Hippocampus; Long-Term Potentiation; Male; Naloxone; Naltrexone; Pyrrolidines; Receptors, Opioid, kappa; Synaptic Transmission

1994
Differential binding domains of peptide and non-peptide ligands in the cloned rat kappa opioid receptor.
    The Journal of biological chemistry, 1994, Dec-02, Volume: 269, Issue:48

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Animals; Base Sequence; Benzeneacetamides; Binding Sites; Binding, Competitive; Cell Line; Chlorocebus aethiops; Cloning, Molecular; Diprenorphine; DNA Primers; Dynorphins; Endorphins; Kinetics; Ligands; Molecular Sequence Data; Naltrexone; Polymerase Chain Reaction; Protein Conformation; Protein Structure, Secondary; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Fusion Proteins; Transfection

1994
Endogenous dynorphins inhibit excitatory neurotransmission and block LTP induction in the hippocampus.
    Nature, 1993, Jun-03, Volume: 363, Issue:6428

    Topics: Action Potentials; Animals; Benzeneacetamides; Dynorphins; Glutamates; Glutamic Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; Naltrexone; Neural Inhibition; Neurotransmitter Agents; Pyrrolidines; Receptors, Opioid, kappa; Synapses; Time Factors

1993
Antagonistic effects of the selective, competitive N-methyl-D-aspartate (NMDA) receptor antagonist, NPC 12626, on kappa opiate-induced analgesia in male deer mice.
    Brain research, 1994, Feb-21, Volume: 637, Issue:1-2

    Topics: Amino Acids; Analgesics; Animals; Benzeneacetamides; Dizocilpine Maleate; Dose-Response Relationship, Drug; Male; Morphine; Naloxone; Naltrexone; Nociceptors; Pain Measurement; Peromyscus; Pyrrolidines; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa

1994
Interacting presynaptic kappa-opioid and GABAA receptors modulate dopamine release from rat striatal synaptosomes.
    Journal of neurochemistry, 1993, Volume: 61, Issue:5

    Topics: Analysis of Variance; Animals; Benzeneacetamides; Bicuculline; Corpus Striatum; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; gamma-Aminobutyric Acid; Kinetics; Male; Naltrexone; Narcotics; Oligopeptides; Picrotoxin; Potassium; Pyrrolidines; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Opioid, kappa; Synaptosomes

1993
Naltrexone in vivo protects mu receptors from inactivation by beta-funaltrexamine, but not kappa receptors from inactivation by nor-binaltorphimine.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 46, Issue:4

    Topics: Analgesics; Animals; Benzeneacetamides; Cisterna Magna; Dose-Response Relationship, Drug; Injections; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu

1993
kappa-Opioid agonist modulation of [3H]thymidine incorporation into DNA: evidence for the involvement of pertussis toxin-sensitive G protein-coupled phosphoinositide turnover.
    Journal of neurochemistry, 1993, Volume: 60, Issue:4

    Topics: Alkaloids; Animals; Atropine; Autoradiography; Benzeneacetamides; Benzophenanthridines; Brain; Chlorides; DNA; Endorphins; GTP-Binding Proteins; Lithium; Lithium Chloride; Naltrexone; Pertussis Toxin; Phenanthridines; Phosphatidylinositols; Phosphoric Monoester Hydrolases; Protein Kinase C; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Virulence Factors, Bordetella

1993
kappa-Opioid receptor agonists prevent sensitization to the conditioned rewarding effects of cocaine.
    The Journal of pharmacology and experimental therapeutics, 1996, Volume: 276, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Cocaine; Conditioning, Psychological; Dopamine; Male; Naltrexone; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reward

1996
The NMDA receptor antagonist MK-801 differentially modulates mu and kappa opioid actions in spinal cord in vitro.
    Pain, 1996, Volume: 66, Issue:2-3

    Topics: Analgesics; Animals; Animals, Newborn; Benzeneacetamides; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; In Vitro Techniques; Membrane Potentials; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord

1996
kappa-opioid receptor expression defines a phenotypically distinct subpopulation of astroglia: relationship to Ca2+ mobilization, development, and the antiproliferative effect of opioids.
    Brain research, 1996, Oct-21, Volume: 737, Issue:1-2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Astrocytes; Benzeneacetamides; Bromodeoxyuridine; Calcium; Calcium Channel Blockers; Cell Count; Cell Division; Cells, Cultured; DNA; Enzyme Inhibitors; Gene Expression Regulation, Developmental; Immunohistochemistry; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Nifedipine; Phenotype; Pyrrolidines; Receptors, Opioid, kappa; Thapsigargin; Time Factors

1996
Increased release of excitatory amino acids in rat locus coeruleus in kappa-opioid agonist dependent rats precipitated by nor-binaltorphimine.
    Brain research, 1997, Apr-04, Volume: 753, Issue:1

    Topics: Animals; Benzeneacetamides; Butorphanol; Drug Evaluation, Preclinical; Excitatory Amino Acids; Locus Coeruleus; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Substance-Related Disorders

1997
Kappa receptor activation attenuates L-trans-pyrrolidine-2,4-dicarboxylic acid-evoked glutamate levels in the striatum.
    Journal of neurochemistry, 1998, Volume: 70, Issue:2

    Topics: Animals; Benzeneacetamides; Calcium; Corpus Striatum; Dicarboxylic Acids; Glutamic Acid; Kinetics; Male; Microdialysis; Naltrexone; Neurotransmitter Uptake Inhibitors; Perfusion; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa

1998
Structural features determining differential receptor regulation of neuronal Ca channels.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998, May-15, Volume: 18, Issue:10

    Topics: Analgesics; Barium; Benzeneacetamides; Calcium Channels; Cell Line; Electrophysiology; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Ion Channel Gating; Mutagenesis; Naltrexone; Narcotic Antagonists; Neurons; Protein Structure, Tertiary; Pyrrolidines; Receptors, Opioid, kappa; Recombinant Fusion Proteins; Transfection

1998
Identification of L-type calcium channels associated with kappa opioid receptors in human placenta.
    Journal of molecular neuroscience : MN, 1998, Volume: 10, Issue:3

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Benzeneacetamides; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Cell Membrane; Chorionic Gonadotropin; Chorionic Villi; Culture Techniques; Egtazic Acid; Female; Humans; Isradipine; Naltrexone; Nifedipine; Placenta; Pyrrolidines; Receptors, Opioid, kappa; Trophoblasts

1998
Peripheral component in the enhanced antinociceptive effect of systemic U-69,593, a kappa-opioid receptor agonist in mononeuropathic rats.
    European journal of pharmacology, 1998, Sep-18, Volume: 357, Issue:2-3

    Topics: Analgesics; Animals; Benzeneacetamides; Injections, Intravenous; Male; Naltrexone; Narcotic Antagonists; Nerve Compression Syndromes; Pain Measurement; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Sciatic Nerve; Somatostatin

1998
5-HT4 receptor agonists and delta-opioid receptor antagonists act synergistically to stimulate colonic propulsion.
    The American journal of physiology, 1998, Volume: 275, Issue:5

    Topics: Animals; Benzeneacetamides; Colon; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Peptide Fragments; Peristalsis; Pyrrolidines; Receptors, Opioid, delta; Receptors, Serotonin; Receptors, Serotonin, 5-HT4; Serotonin Receptor Agonists; Somatostatin

1998
Opioid efficacy in a C6 glioma cell line stably expressing the human kappa opioid receptor.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 288, Issue:2

    Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Glioma; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Receptors, Opioid, kappa; Stereoisomerism; Transfection; Tritium; Tumor Cells, Cultured

1999
[A molecular mechanism for supersensitization of adenylyl cyclase system in cloned opioid receptor-transfected cells following sustained opioid treatment].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1998, Volume: 112 Suppl 1

    Topics: Adenylyl Cyclases; Analgesics; Animals; Atropine; Benzeneacetamides; Carbachol; CHO Cells; Clone Cells; Cricetinae; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP Phosphohydrolases; Morphine; Muscarinic Agonists; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Transfection

1998
Effects of U-69,593, a kappa-opioid receptor agonist, on carrageenin-induced peripheral oedema and Fos expression in the rat spinal cord.
    European journal of pharmacology, 1999, Apr-16, Volume: 370, Issue:3

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Benzeneacetamides; Carrageenan; Dose-Response Relationship, Drug; Drug Interactions; Edema; Immunochemistry; Inflammation; Male; Naltrexone; Narcotic Antagonists; Photomicrography; Proto-Oncogene Proteins c-fos; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Spinal Cord

1999
Supersensitization of the adenylyl cyclase system in Chinese hamster ovary cells co-expressing cloned opioid receptors and Gz, a PTX-insensitive G protein.
    Neuroscience letters, 1999, May-28, Volume: 267, Issue:2

    Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Benzeneacetamides; CHO Cells; Cricetinae; Cyclic AMP; Enzyme Activation; Female; GTP-Binding Protein alpha Subunits; Heterotrimeric GTP-Binding Proteins; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pertussis Toxin; Pyrrolidines; Receptors, Opioid; Virulence Factors, Bordetella

1999
kappa-Opioid tolerance and dependence in cultures of dopaminergic midbrain neurons.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999, Jul-15, Volume: 19, Issue:14

    Topics: Analgesics; Analysis of Variance; Animals; Benzeneacetamides; Cells, Cultured; Dopamine; Fetus; Kinetics; Mesencephalon; Naltrexone; Narcotic Antagonists; Neurons; Pertussis Toxin; Potassium; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Regression Analysis; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tetrodotoxin; Time Factors; Transcription, Genetic; Virulence Factors, Bordetella

1999
Differential antagonism of the rate-decreasing effects of kappa-opioid receptor agonists by naltrexone and norbinaltorphimine.
    European journal of pharmacology, 1999, Jul-14, Volume: 377, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Benzeneacetamides; Benzofurans; Benzomorphans; Conditioning, Operant; Dose-Response Relationship, Drug; Ethylketocyclazocine; Nalorphine; Naltrexone; Narcotic Antagonists; Pyrroles; Pyrrolidines; Receptors, Opioid, kappa; Reinforcement Schedule; Saimiri; Thiophenes

1999
The kappa-opioid agonist, U-69593, decreases acute amphetamine-evoked behaviors and calcium-dependent dialysate levels of dopamine and glutamate in the ventral striatum.
    Journal of neurochemistry, 1999, Volume: 73, Issue:3

    Topics: Amphetamine; Animals; Behavior, Animal; Benzeneacetamides; Calcium; Dopamine; Glutamic Acid; Male; Microdialysis; Naltrexone; Narcotic Antagonists; Neostriatum; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa

1999
Opioid peptide receptor studies. 10. Nor-BNI differentially inhibits kappa receptor agonist-induced G-protein activation in the guinea pig caudate: further evidence of kappa receptor heterogeneity.
    Synapse (New York, N.Y.), 1999, Dec-15, Volume: 34, Issue:4

    Topics: Animals; Benzeneacetamides; Benzodiazepines; Brain; Caudate Nucleus; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; In Vitro Techniques; Inhibitory Concentration 50; Naltrexone; Oligopeptides; Peptide Fragments; Peptides; Pyrrolidines; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin

1999
Receptor selectivity of Met-enkephalin-Arg6-Phe7, an endogenous opioid peptide, in cerebral cortex of human and rat.
    Life sciences, 2000, May-26, Volume: 67, Issue:1

    Topics: Adult; Animals; Benzeneacetamides; Benzomorphans; Binding Sites; Cerebral Cortex; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Ethylketocyclazocine; Female; Humans; Male; Naloxone; Naltrexone; Norepinephrine; Oligopeptides; Peptide Fragments; Peptides; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Somatostatin

2000
Kappa-opioid receptor modulation of nicotine-induced behaviour.
    Neuropharmacology, 2000, Volume: 39, Issue:13

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Animal; Benzeneacetamides; Benzofurans; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Motor Activity; Naltrexone; Nicotine; Nicotinic Agonists; Pyrrolidines; Rats; Receptors, Opioid, kappa

2000
Kappa-opioid receptor activation modifies dopamine uptake in the nucleus accumbens and opposes the effects of cocaine.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, Dec-15, Volume: 20, Issue:24

    Topics: Analysis of Variance; Animals; Autoradiography; Benzeneacetamides; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Drug Administration Schedule; Drug Antagonism; Extracellular Space; Injections, Intraperitoneal; Injections, Subcutaneous; Iodine Radioisotopes; Linear Models; Male; Membrane Glycoproteins; Membrane Transport Proteins; Microdialysis; Naltrexone; Nerve Tissue Proteins; Nucleus Accumbens; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa

2000
Opioids suppress basal and nicotine-induced catecholamine secretion via a stabilizing effect on actin filaments.
    Endocrinology, 2001, Volume: 142, Issue:5

    Topics: Actins; Animals; Benzeneacetamides; Cytochalasin B; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Humans; Naltrexone; Narcotics; Nicotine; Norepinephrine; PC12 Cells; Pyrrolidines; Rats

2001
Analgesic and antiinflammatory effects of two novel kappa-opioid peptides.
    Anesthesiology, 2001, Volume: 94, Issue:6

    Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzeneacetamides; Dose-Response Relationship, Drug; Inflammation; Injections, Spinal; Male; Naloxone; Naltrexone; Narcotic Antagonists; Opioid Peptides; Pain Threshold; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa

2001
GR89,696: a potent kappa-opioid agonist with subtype selectivity in rhesus monkeys.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 298, Issue:3

    Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Benzeneacetamides; Cerebral Cortex; Discrimination, Psychological; Diuresis; Ethylketocyclazocine; Female; Guanosine 5'-O-(3-Thiotriphosphate); Macaca mulatta; Male; Membranes; Muscle Relaxation; Naltrexone; Pain Measurement; Piperazines; Prolactin; Pyrrolidines; Radioligand Assay; Receptors, Opioid, kappa; Respiratory Mechanics

2001
Kappa opioid antagonist effects of the novel kappa antagonist 5'-guanidinonaltrindole (GNTI) in an assay of schedule-controlled behavior in rhesus monkeys.
    Psychopharmacology, 2002, Volume: 163, Issue:3-4

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Animals; Benzamides; Benzeneacetamides; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Female; Guanidines; Macaca mulatta; Male; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Piperazines; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Reinforcement Schedule; Time Factors

2002
Agonist/antagonist properties of nalbuphine, butorphanol and (-)-pentazocine in male vs. female rats.
    Pharmacology, biochemistry, and behavior, 2003, Volume: 75, Issue:1

    Topics: Animals; Benzeneacetamides; Butorphanol; Diuresis; Diuretics; Dose-Response Relationship, Drug; Female; Male; Nalbuphine; Naltrexone; Narcotic Antagonists; Pentazocine; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sex Characteristics; Urination

2003
Kappa-opioid agonists directly inhibit midbrain dopaminergic neurons.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Nov-05, Volume: 23, Issue:31

    Topics: Analgesics; Animals; Benzeneacetamides; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; In Vitro Techniques; Male; Mesencephalon; Naltrexone; Narcotic Antagonists; Neural Inhibition; Neurons; Patch-Clamp Techniques; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Ventral Tegmental Area

2003
Region-dependent G-protein activation by kappa-opioid receptor agonists in the mouse brain.
    Neuroscience letters, 2004, Feb-12, Volume: 356, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Brain; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Morphinans; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, kappa; Spiro Compounds

2004
Kappa-opioid receptor-mediated effects of the plant-derived hallucinogen, salvinorin A, on inverted screen performance in the mouse.
    Behavioural pharmacology, 2005, Volume: 16, Issue:8

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Benzeneacetamides; Diterpenes; Diterpenes, Clerodane; Hallucinogens; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Piperidines; Psychotropic Drugs; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Remifentanil

2005
Paradoxical effects of prodynorphin gene deletion on basal and cocaine-evoked dopaminergic neurotransmission in the nucleus accumbens.
    The European journal of neuroscience, 2006, Volume: 23, Issue:1

    Topics: Analgesics; Animals; Area Under Curve; Behavior, Animal; Benzeneacetamides; Chromatography, High Pressure Liquid; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Dynorphins; Electrochemistry; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Motor Activity; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Pyrrolidines

2006
Pharmacological and genetic manipulation of kappa opioid receptors: effects on cocaine- and pentylenetetrazol-induced convulsions and seizure kindling.
    Neuropharmacology, 2007, Volume: 52, Issue:3

    Topics: Analgesics; Animals; Behavior, Animal; Benzeneacetamides; Cocaine; Dose-Response Relationship, Drug; Drug Interactions; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Narcotic Antagonists; Pentylenetetrazole; Pyrrolidines; Receptors, Opioid, kappa; Seizures

2007
Mu and kappa opioids modulate mouse embryonic stem cell-derived neural progenitor differentiation via MAP kinases.
    Journal of neurochemistry, 2010, Volume: 112, Issue:6

    Topics: Analgesics, Opioid; Animals; Antigens; Benzeneacetamides; Cell Differentiation; Cells, Cultured; Drug Interactions; Embryo, Mammalian; Embryonic Stem Cells; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Mice; Mitogen-Activated Protein Kinase Kinases; Naltrexone; Narcotic Antagonists; Oligodendroglia; Peptides; Proteoglycans; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Time Factors; Tretinoin; Tubulin

2010
Effects of kappa opioids in an assay of pain-depressed intracranial self-stimulation in rats.
    Psychopharmacology, 2010, Volume: 210, Issue:2

    Topics: Analgesics; Analgesics, Opioid; Animals; Benzeneacetamides; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Lactic Acid; Male; Medial Forebrain Bundle; Morphine; Naltrexone; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reinforcement, Psychology; Self Stimulation

2010
The effects of kappa-opioid receptor ligands on prepulse inhibition and CRF-induced prepulse inhibition deficits in the rat.
    Psychopharmacology, 2010, Volume: 210, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Corticotropin-Releasing Hormone; Diterpenes, Clerodane; Dose-Response Relationship, Drug; Ligands; Male; Naltrexone; Neural Inhibition; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reflex, Startle

2010
Differential expression and sensitivity of presynaptic and postsynaptic opioid receptors regulating hypothalamic proopiomelanocortin neurons.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Jan-05, Volume: 31, Issue:1

    Topics: Analgesics; Analgesics, Opioid; Analysis of Variance; Animals; Benzeneacetamides; Dizocilpine Maleate; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Gene Expression; Hypothalamus; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Luminescent Proteins; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; Naltrexone; Narcotic Antagonists; Neural Inhibition; Neurons; Patch-Clamp Techniques; Peptide Fragments; Pro-Opiomelanocortin; Pyrrolidines; Quinoxalines; Receptors, Opioid; Somatostatin; Synapses

2011
Activation of κ opioid receptors increases intrinsic excitability of dentate gyrus granule cells.
    The Journal of physiology, 2011, Jul-15, Volume: 589, Issue:Pt 14

    Topics: 4-Aminopyridine; Action Potentials; Animals; Benzeneacetamides; Dentate Gyrus; Dynorphins; GTP-Binding Proteins; Guanosine Diphosphate; Male; Mice; Mice, 129 Strain; Naltrexone; Neurons; Patch-Clamp Techniques; Potassium Channels; Pyrrolidines; Receptors, Opioid, kappa; Thionucleotides

2011
Prefrontal cortical kappa-opioid receptor modulation of local neurotransmission and conditioned place aversion.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2013, Volume: 38, Issue:9

    Topics: Analgesics; Animals; Avoidance Learning; Benzeneacetamides; Dicarboxylic Acids; Dopamine; Drug Interactions; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Glutamic Acid; Male; Mice; Mice, Knockout; Microinjections; Miniature Postsynaptic Potentials; Naltrexone; Narcotic Antagonists; Neurotransmitter Uptake Inhibitors; Prefrontal Cortex; Pyramidal Cells; Pyrrolidines; Rats; Receptors, Opioid, kappa; Synaptic Transmission

2013
Physical presence of nor-binaltorphimine in mouse brain over 21 days after a single administration corresponds to its long-lasting antagonistic effect on κ-opioid receptors.
    The Journal of pharmacology and experimental therapeutics, 2013, Volume: 346, Issue:3

    Topics: Analgesics; Animals; Benzeneacetamides; Brain; Chromatography, High Pressure Liquid; Hot Temperature; Injections, Intraventricular; Membranes; Mice; Mice, Inbred C57BL; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Pyrrolidines; Receptors, Opioid, kappa; Reference Standards; Tandem Mass Spectrometry; Time Factors

2013
Pain-related depression of the mesolimbic dopamine system in rats: expression, blockade by analgesics, and role of endogenous κ-opioids.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014, Volume: 39, Issue:3

    Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Depression; Disease Models, Animal; Dopamine; Gene Expression Regulation; Ketoprofen; Lactic Acid; Male; Medial Forebrain Bundle; Morphine; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Self Stimulation; Time Factors

2014
Kappa opioid receptor activation decreases inhibitory transmission and antagonizes alcohol effects in rat central amygdala.
    Neuropharmacology, 2014, Volume: 77

    Topics: Amygdala; Animals; Benzeneacetamides; Dynorphins; Ethanol; Inhibitory Postsynaptic Potentials; Male; Naltrexone; Narcotic Antagonists; Patch-Clamp Techniques; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa

2014
Zyklophin, a short-acting kappa opioid antagonist, induces scratching in mice.
    Neuroscience letters, 2014, Mar-20, Volume: 563

    Topics: Animals; Benzeneacetamides; Dose-Response Relationship, Drug; Dynorphins; Injections, Subcutaneous; Male; Mice; Mice, Knockout; Naltrexone; Peptide Fragments; Pruritus; Pyrrolidines; Radioligand Assay; Receptors, Opioid, kappa

2014
Opposite effects of neuropeptide FF on central antinociception induced by endomorphin-1 and endomorphin-2 in mice.
    PloS one, 2014, Volume: 9, Issue:8

    Topics: Adamantane; Animals; Benzeneacetamides; Dipeptides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Injections, Intraventricular; Male; Mice; Naltrexone; Nociception; Oligopeptides; Pyrrolidines

2014
Prefrontal Cortical Kappa Opioid Receptors Attenuate Responses to Amygdala Inputs.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015, Volume: 40, Issue:13

    Topics: Analgesics, Opioid; Animals; Anti-Anxiety Agents; Anxiety; Basolateral Nuclear Complex; Benzeneacetamides; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; Male; Mice, Inbred C57BL; Microelectrodes; Naltrexone; Narcotic Antagonists; Neural Pathways; Optogenetics; Prefrontal Cortex; Pyrrolidines; Random Allocation; Rats, Long-Evans; Receptors, Opioid, kappa

2015
Age-dependent regulation of GABA transmission by kappa opioid receptors in the basolateral amygdala of Sprague-Dawley rats.
    Neuropharmacology, 2017, 05-01, Volume: 117

    Topics: Aging; Animals; Basolateral Nuclear Complex; Benzeneacetamides; gamma-Aminobutyric Acid; Glutamic Acid; Inhibitory Postsynaptic Potentials; Male; Naltrexone; Pyrrolidines; Rats; Receptors, Opioid, kappa; Synaptic Transmission

2017
Role of dorsal hippocampus κ opioid receptors in contextual aversive memory consolidation in rats.
    Neuropharmacology, 2018, Volume: 135

    Topics: Analgesics, Opioid; Animals; Association; Avoidance Learning; Benzeneacetamides; Conditioning, Psychological; Electroshock; Freezing Reaction, Cataleptic; Hippocampus; Male; Memory Consolidation; Naltrexone; Narcotic Antagonists; Piperazines; Psychotropic Drugs; Pyrrolidines; Random Allocation; Rats, Wistar; Receptors, Opioid, kappa

2018