Page last updated: 2024-08-26

u 69593 and naloxone

u 69593 has been researched along with naloxone in 87 studies

Research

Studies (87)

Timeframe	Studies, this research(%)	All Research%
pre-1990	10 (11.49)	18.7374
1990's	52 (59.77)	18.2507
2000's	11 (12.64)	29.6817
2010's	14 (16.09)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Befort, K; Bloch, B; Charron, G; Gavériaux-Ruff, C; Kieffer, B; Lannes, B; Mattéi, MG; Matthes, H; Micheletti, G; Simonin, F	1
Akil, H; Goldstein, A; Mansour, A; Meng, F; Thompson, RC; Watson, SJ; Xie, GX	1
Chen, Y; Liu, J; Mestek, A; Yu, L	1
Bell, GI; Breder, CD; Kong, H; Raynor, K; Reisine, T; Takeda, J; Yasuda, K	1
Adapa, ID; Auh, JS; Berzetei-Gurske, IP; Brandt, SR; Craymer, K; Farrington, L; Haggart, D; Kennedy, JM; O'Brien, A; Polgar, WE; Rodriguez, L; Schwartz, RW; Toll, L; White, A	1
Englberger, W; Geiger, C; Lehmkuhl, K; Schepmann, D; Wünsch, B; Zelenka, C	1
Dersch, CM; Deschamps, JR; Iyer, MR; Jacobson, AE; Lee, YS; Rice, KC; Rothman, RB	1
Dersch, CM; Iyer, MR; Jacobson, AE; Rice, KC; Rothman, RB	2
Ambo, A; Cai, J; Cai, Y; Lam, AL; Lazarus, LH; Li, T; Ma, Y; Magiera, J; Sasaki, Y; Sekar, S; Smith, MT; Song, B; Wyse, BD	1
Bourgeois, C; Schepmann, D; Werfel, E; Wünsch, B	1
Bourgeois, C; Christoph, T; Englberger, W; Galla, F; Galla, HJ; Hüwel, S; Kögel, B; Lehmkuhl, K; Schepmann, D; Soeberdt, M; Straßburger, W; Torres-Gómez, H; Werfel, E; Wünsch, B	1
Abels, C; Aerts, SN; Autar, R; Bolster, MG; Bouzanne des Mazery, R; Frehland, B; Huang, TY; Knie, U; Lai, CC; Lin, KY; Lotts, T; Metze, D; Molenveld, P; Schepmann, D; Soeberdt, M; Ständer, S; Sterk, GJ; Storcken, RP; Tangherlini, G; van Holst, FR; Wagner, C; Wegert, A; Wünsch, B	1
Che, T; Kalinin, DV; Loser, K; Mykicki, N; Schepmann, D; Ständer, S; Tangherlini, G; Wünsch, B	1
Dickenson, AH; Stanfa, LC; Sullivan, AF	1
Gu, ZF; Jensen, RT; Maton, PN; Pradhan, T; Zhang, L	1
Argiolas, A; Gessa, GL; Melis, MR; Stancampiano, R	1
Finberg, RW; Heagy, W; Shipp, MA	1
Bidlack, JM; Lawrence, DM; Saripalli, LD	1
Caudle, RM; Chavkin, C; Wagner, JJ	1
Colpaert, FC; Millan, MJ	3
Bansinath, M; Ramabadran, K; Shukla, VK; Turndorf, H	1
Cheng, J; Pasternak, GW; Paul, D; Pick, CG	1
Adler, MW; Eisenstein, TK; Geller, EB; Rogers, TJ; Taub, DD	1
Birch, PJ; Hayes, AG; Hayward, NJ; Judd, DB; Naylor, A; Rogers, H; Scopes, DI; Sheehan, MJ; Tyers, MB	1
Caliezi, A; Drack, E; Halter, F; Scheurer, U; Varga, L; Wenger, F	1
Alzheimer, C; ten Bruggencate, G	1
Bettaney, J; Dray, A; James, IF; Ketchum, SB; Perkins, MN	1
Christensen, JD; Fjalland, B	1
Dissanayake, VU; Hill, RG; Hughes, J; Hunter, JC	1
Baraldi, M; Zanoli, P	1
Kaneto, H; Shiigi, Y; Takahashi, M	1
Makimura, M; Murakoshi, Y	1
Dashwood, MR; Mathias, CJ; May, CN; Whitehead, CJ	1
Bruce, DS; Nuchols, PA; Oeltgen, PR; Spurrier, WA; Su, TP; Welborn, JR	1
La Regina, A; Petrillo, P; Sbacchi, M; Tavani, A	1
Herz, A; Shippenberg, TS	2
Frey, HH	1
Herz, A; Millan, MJ; Mucha, RF; Shippenberg, TS	1
Lahti, RA; McCall, JM; Mickelson, MM; Von Voigtlander, PF	1
Cheney, BV; Lahti, RA	1
Garzón, J; Sánchez-Blázquez, P	1
Kuznetsov, A; Ma, GH; Miller, RJ; Philipson, LH	1
Glick, SD; Herrick-Davis, K; Pearl, SM; Teitler, M	1
Avidor-Reiss, T; Barg, J; Ezra, V; Levy, R; Matus-Leibovitch, N; Saya, D; Vogel, Z; Zippel, R	1
Bidlack, JM; Joseph, DB	1
Búzás, B; Cox, BM; Izenwasser, S	1
Chavkin, C; Terman, GW; Wagner, JJ	1
Macdonald, RL; Moises, HC; Rusin, KI	1
Bell, GI; Kong, H; Raynor, K; Reisine, T; Takeda, J; Yano, H	1
Kavaliers, M; Saucier, DM	1
Headley, PM; Herrero, JF	1
Ishige, K; Ito, Y; Makimura, M; Murakoshi, Y	1
Desmeules, JA; Guilbaud, G; Kayser, V	1
Feng, J; Kendig, JJ	1
Duncan, MJ; Elde, RP; Gurwell, JA; Hauser, KF; Maderspach, K; Stiene-Martin, A	1
Ho, IK; Hoshi, K; Ma, T	1
Argiolas, A; Iannucci, U; Melis, MR; Succu, S	1
Fowler, CJ; Tiger, G	1
Brines, ML; de Lanerolle, NC; Kim, JH; Meredith, C; Spencer, DD; Tabuteau, H; Williamson, A	1
Hogenboom, F; Mulder, AH; Schoffelmeer, AN	1
Gauthier, CA; Gonzales, GR; Minor, LD; Paul, D	1
Argiolas, A; Melis, MR; Succu, S	1
Borsodi, A; Hosztafi, S; Nevin, ST; Rónai, AZ; Spetea, M; Tóth, G	1
Akil, H; Clark, MJ; Mansour, A; Medzihradsky, F; Remmers, AE; Woods, JH	1
Minami, M; Nakagawa, T; Ozawa, T; Satoh, M; Watanabe, T	1
Argiolas, A; Melis, MR; Spano, MS; Succu, S	1
Minami, M; Nakagawa, T; Ozawa, T; Satoh, M	1
Cheong, YP; Cho, KP; Kim, CJ; Kim, JK; Kim, KW; Kwun, J; Woo, RS	1
Binder, W; Junien, JL; Machelska, H; Mousa, S; Rivière, PJ; Schäfer, M; Schmitt, T; Stein, C	1
Schoffelmeer, AN; Vanderschuren, LJ; Wardeh, G	1
Martin-Kleiner, I	1
Irvine, RJ; Lewanowitsch, T	1
Holtzman, SG; White, DA	1
Choi, DH; Jung, EB; Kim, MS; Kim, TY; Lee, J; Moon, SK; Park, C; Park, R	1
Fantegrossi, WE; Koreeda, M; Kugle, KM; Valdes, LJ; Woods, JH	1
Howells, RD; Wannemacher, KM; Yadav, PN	1
Juma, F; Kanui, TI; Maloiy, GM; Olongida Ole Miaron, J; Towett, PK	1
DeLeo, JA; Horvath, RJ	1
Bertini, S; Menozzi, A; Poli, E; Pozzoli, C; Serventi, P; Zullian, C	1
Ganno, ML; McLaughlin, JP; Patkar, KA; Rasakham, K; Ross, NC; Singh, HD; Toll, L; Wu, J	1
Bogen, O; Ferrari, LF; Gear, RW; Green, PG; Levine, JD	1
Arida, RM; Brand, S; Cavalheiro, EA; de Almeida, AA; Gomes da Silva, S; Rocha, L; Zavala-Tecuapetla, C	1
Guerrieri, E; Mallareddy, JR; Schmidhammer, H; Spetea, M; Tóth, G	1

Other Studies

87 other study(ies) available for u 69593 and naloxone

Article	Year
kappa-Opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system. Proceedings of the National Academy of Sciences of the United States of America, 1995, Jul-18, Volume: 92, Issue:15 Topics: Adenylyl Cyclases; Aged; Amino Acid Sequence; Base Sequence; Central Nervous System; Chromosome Mapping; Chromosomes, Human, Pair 8; Cloning, Molecular; DNA, Complementary; Exons; Genomic Library; Humans; In Situ Hybridization; Ligands; Middle Aged; Molecular Sequence Data; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins; RNA, Messenger; Sequence Homology, Amino Acid; Signal Transduction; Tissue Distribution	1995
Cloning and pharmacological characterization of a rat kappa opioid receptor. Proceedings of the National Academy of Sciences of the United States of America, 1993, Nov-01, Volume: 90, Issue:21 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Analgesics; Animals; Benzeneacetamides; Cell Line; Cell Membrane; Cloning, Molecular; Corpus Striatum; Cyclic AMP; DNA Primers; DNA, Complementary; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gene Library; In Situ Hybridization; Inositol 1,4,5-Trisphosphate; Kinetics; Ligands; Molecular Sequence Data; Pyrrolidines; Rats; Receptors, Opioid, kappa; Restriction Mapping; RNA, Messenger; Transfection	1993
Molecular cloning of a rat kappa opioid receptor reveals sequence similarities to the mu and delta opioid receptors. The Biochemical journal, 1993, Nov-01, Volume: 295 ( Pt 3) Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Benzomorphans; Cloning, Molecular; Diprenorphine; DNA, Complementary; Molecular Sequence Data; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sequence Analysis; Sequence Homology, Amino Acid; Transfection	1993
Cloning and functional comparison of kappa and delta opioid receptors from mouse brain. Proceedings of the National Academy of Sciences of the United States of America, 1993, Jul-15, Volume: 90, Issue:14 Topics: Amino Acid Sequence; Animals; Base Sequence; Brain Chemistry; Cloning, Molecular; In Situ Hybridization; Mice; Molecular Sequence Data; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Somatostatin; RNA, Messenger; Sequence Homology, Amino Acid; Substrate Specificity; Tissue Distribution	1993
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications. NIDA research monograph, 1998, Volume: 178 Topics: Animals; Aorta, Thoracic; Cocaine; Cyclic AMP; Electric Stimulation; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Opioid-Related Disorders; Rats; Receptors, Dopamine; Receptors, Opioid; Receptors, Serotonin; Substance-Related Disorders	1998
Conformationally constrained kappa receptor agonists: stereoselective synthesis and pharmacological evaluation of 6,8-diazabicyclo[3.2.2]nonane derivatives. Journal of medicinal chemistry, 2010, May-27, Volume: 53, Issue:10 Topics: Animals; Azabicyclo Compounds; Cell Line; Guinea Pigs; Humans; In Vitro Techniques; Molecular Conformation; Radioligand Assay; Receptors, Opioid, kappa; Stereoisomerism; Structure-Activity Relationship	2010
Probes for narcotic receptor mediated phenomena. 44. Synthesis of an N-substituted 4-hydroxy-5-(3-hydroxyphenyl)morphan with high affinity and selective μ-antagonist activity. European journal of medicinal chemistry, 2012, Volume: 50 Topics: Animals; Azabicyclo Compounds; CHO Cells; Cricetinae; Cricetulus; Crystallography, X-Ray; Guanosine 5'-O-(3-Thiotriphosphate); Molecular Structure; Morphinans; Narcotic Antagonists; Protein Binding; Receptors, Opioid; Receptors, Opioid, mu; Stereoisomerism; Structure-Activity Relationship	2012
Probes for narcotic receptor mediated phenomena. 47. Novel C4a- and N-substituted-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-6-ols. Bioorganic & medicinal chemistry, 2013, Jun-01, Volume: 21, Issue:11 Topics: Animals; Cell Membrane; CHO Cells; Cricetulus; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Molecular Structure; Narcotic Antagonists; Pyridines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship; Sulfur Radioisotopes; Tritium	2013
Endomorphin analogues with mixed μ-opioid (MOP) receptor agonism/δ-opioid (DOP) receptor antagonism and lacking β-arrestin2 recruitment activity. Bioorganic & medicinal chemistry, 2014, Apr-01, Volume: 22, Issue:7 Topics: Animals; Arrestins; beta-Arrestins; Colforsin; Cyclic AMP; Guinea Pigs; HEK293 Cells; Humans; Male; Mice; Molecular Structure; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu	2014
Combination of cyclohexane and piperazine based κ-opioid receptor agonists: Synthesis and pharmacological evaluation of trans,trans-configured perhydroquinoxalines. Bioorganic & medicinal chemistry, 2014, Jul-01, Volume: 22, Issue:13 Topics: Cyclohexanes; Dose-Response Relationship, Drug; Humans; Molecular Structure; Piperazine; Piperazines; Quinoxalines; Receptors, Opioid, kappa; Stereoisomerism; Structure-Activity Relationship	2014
Synthesis and pharmacological evaluation of 5-pyrrolidinylquinoxalines as a novel class of peripherally restricted κ-opioid receptor agonists. Journal of medicinal chemistry, 2014, Aug-14, Volume: 57, Issue:15 Topics: Analgesics, Opioid; Animals; Binding, Competitive; Blood-Brain Barrier; Brain; Endothelial Cells; Guinea Pigs; HEK293 Cells; Humans; Liver; Male; Mice; Models, Molecular; Pain Measurement; Permeability; Pyrrolidines; Quinoxalines; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma; Stereoisomerism; Structure-Activity Relationship	2014
Probes for narcotic receptor mediated phenomena 49. N-substituted rac-cis-4a-arylalkyl-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-6-ols. European journal of medicinal chemistry, 2015, Mar-06, Volume: 92 Topics: Benzofurans; Dose-Response Relationship, Drug; Heterocyclic Compounds, 3-Ring; Humans; Molecular Structure; Piperidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship	2015
Design and Synthesis of Enantiomerically Pure Decahydroquinoxalines as Potent and Selective κ-Opioid Receptor Agonists with Anti-Inflammatory Activity in Vivo. Journal of medicinal chemistry, 2017, 03-23, Volume: 60, Issue:6 Topics: Animals; Anti-Inflammatory Agents; Dermatitis; Drug Design; Guinea Pigs; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Quinoxalines; Rats, Wistar; Receptors, Opioid, kappa; Skin	2017
Development of Novel Quinoxaline-Based κ-Opioid Receptor Agonists for the Treatment of Neuroinflammation. Journal of medicinal chemistry, 2019, 01-24, Volume: 62, Issue:2 Topics: Animals; Antineoplastic Agents; Binding Sites; Encephalomyelitis, Autoimmune, Experimental; HEK293 Cells; Humans; Interferon-gamma; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Docking Simulation; Protein Structure, Tertiary; Quinoxalines; Receptors, Opioid, kappa; Signal Transduction; Structure-Activity Relationship; Th1 Cells	2019
Alterations in neuronal excitability and the potency of spinal mu, delta and kappa opioids after carrageenan-induced inflammation. Pain, 1992, Volume: 50, Issue:3 Topics: Animals; Benzeneacetamides; Carrageenan; Dose-Response Relationship, Drug; Injections, Spinal; Male; Morphine; Myelitis; Naloxone; Neurons; Oligopeptides; Palliative Care; Pyrrolidines; Rats; Rats, Sprague-Dawley	1992
Characterization of opioid receptors on smooth muscle cells from guinea pig stomach. The American journal of physiology, 1992, Volume: 262, Issue:3 Pt 1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gastric Mucosa; Guinea Pigs; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Naloxone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Stomach	1992
Prevention by morphine of apomorphine- and oxytocin-induced penile erection and yawning: site of action in the brain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1992, Volume: 6, Issue:1 Topics: Analgesics; Animals; Apomorphine; Benzeneacetamides; Brain; Injections, Intraventricular; Male; Microinjections; Morphine; Naloxone; Narcotic Antagonists; Oxytocin; Paraventricular Hypothalamic Nucleus; Penile Erection; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Yawning	1992
Opioid receptor agonists and Ca2+ modulation in human B cell lines. Journal of immunology (Baltimore, Md. : 1950), 1992, Dec-15, Volume: 149, Issue:12 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; B-Lymphocytes; Benzeneacetamides; Calcium; Cell Line; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Flow Cytometry; Humans; Naloxone; Pyrrolidines; Receptors, Opioid; Signal Transduction	1992
kappa-Opioid binding sites on a murine lymphoma cell line. European journal of pharmacology, 1992, Nov-02, Volume: 227, Issue:3 Topics: Animals; Benzeneacetamides; Binding Sites; Cell Membrane; Lymphocytes; Lymphoma; Mice; Naloxone; Pyrrolidines; Receptors, Opioid; Tritium; Tumor Cells, Cultured	1992
Kappa-opioids decrease excitatory transmission in the dentate gyrus of the guinea pig hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1992, Volume: 12, Issue:1 Topics: Action Potentials; Animals; Benzeneacetamides; Diprenorphine; Dynorphins; Electrophysiology; Endorphins; Guinea Pigs; Hippocampus; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Synapses	1992
Opioid systems in the response to inflammatory pain: sustained blockade suggests role of kappa- but not mu-opioid receptors in the modulation of nociception, behaviour and pathology. Neuroscience, 1991, Volume: 42, Issue:2 Topics: Analgesics; Animals; Behavior, Animal; Benzeneacetamides; Body Temperature; Body Weight; Inflammation; Male; Morphine; Naloxone; Nociceptors; Pain; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu	1991
Intracerebroventricular administration of kappa-agonists induces convulsions in mice. Brain research bulletin, 1991, Volume: 27, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Baclofen; Benzeneacetamides; Benzomorphans; Cerebral Ventricles; Convulsants; Dizocilpine Maleate; Injections, Intraventricular; Ketamine; Mice; Mice, Inbred Strains; Muscimol; Naloxone; Narcotic Antagonists; Narcotics; Pyrroles; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Seizures; Stereoisomerism; Thiophenes	1991
Genetic influences in opioid analgesic sensitivity in mice. Brain research, 1991, Dec-06, Volume: 566, Issue:1-2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; Benzeneacetamides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mice; Mice, Inbred Strains; Morphine; Naloxone; Pain; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Species Specificity	1991
Immunomodulatory activity of mu- and kappa-selective opioid agonists. Proceedings of the National Academy of Sciences of the United States of America, 1991, Jan-15, Volume: 88, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Antibody Formation; Antibody-Producing Cells; Benzeneacetamides; Cells, Cultured; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Immunosuppression Therapy; Kinetics; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred Strains; Morphine; Naloxone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu	1991
A series of novel, highly potent and selective agonists for the kappa-opioid receptor. British journal of pharmacology, 1990, Volume: 101, Issue:4 Topics: Abdomen; Analgesics; Animals; Benzeneacetamides; Cricetinae; Electric Stimulation; In Vitro Techniques; Male; Mesocricetus; Mice; Mice, Inbred Strains; Muscle Contraction; Muscle, Smooth; Naloxone; Narcotic Antagonists; Pyrrolidines; Rabbits; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Urination; Vas Deferens	1990
Different motor actions of dynorphins and nonpeptide kappa opioid receptor agonists in the isolated rat colon. The Journal of pharmacology and experimental therapeutics, 1990, Volume: 252, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Antihypertensive Agents; Benzeneacetamides; Benzodiazepines; Benzomorphans; Colon; Diuretics; Dynorphins; Gastrointestinal Motility; In Vitro Techniques; Male; Muscle, Smooth; Naloxone; Narcotic Antagonists; Pressure; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa	1990
Nonopioid actions of the kappa-opioid receptor agonists, U 50488H and U 69593 on electrophysiologic properties of hippocampal CA3 neurons in vitro. The Journal of pharmacology and experimental therapeutics, 1990, Volume: 255, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzeneacetamides; Dynorphins; Guinea Pigs; Hippocampus; In Vitro Techniques; Membrane Potentials; Naloxone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa	1990
Modification of nociception in a model of localized inflammatory pain by long-term administration of naloxone. Progress in clinical and biological research, 1990, Volume: 328 Topics: Animals; Benzeneacetamides; Disease Models, Animal; Inflammation; Male; Morphine; Mycobacterium Infections; Naloxone; Nociceptors; Pain; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid	1990
Opioid receptor ligands in the neonatal rat spinal cord: binding and in vitro depression of the nociceptive responses. British journal of pharmacology, 1990, Volume: 99, Issue:3 Topics: Animals; Animals, Newborn; Benzeneacetamides; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; In Vitro Techniques; Kinetics; Ligands; Morphine; Muscle, Smooth, Vascular; Naloxone; Narcotics; Nociceptors; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Spinal Cord	1990
Kappa-opioid receptor agonists differentially affect the release of neurohypophysial hormones. Pharmacology & toxicology, 1990, Volume: 66, Issue:3 Topics: Animals; Benzeneacetamides; Benzomorphans; Electric Stimulation; Female; In Vitro Techniques; Naloxone; Nerve Endings; Oxytocin; Pituitary Hormones, Posterior; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Vasopressins	1990
The influence of sustained opioid receptor blockade in a model of long-term, localized inflammatory pain in rats. Neuroscience letters, 1990, May-18, Volume: 113, Issue:1 Topics: Analgesics; Animals; Benzeneacetamides; Drinking Behavior; Feeding Behavior; Inflammation; Male; Morphine; Naloxone; Pain; Pain Measurement; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu	1990
Characterization of kappa-opioid receptors in the guinea-pig ileum. European journal of pharmacology, 1990, Jun-21, Volume: 182, Issue:1 Topics: Animals; Benzeneacetamides; Benzomorphans; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Kinetics; Muscle Contraction; Muscle, Smooth; Naloxone; Pyrroles; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Thiophenes	1990
Evidence that bremazocine prevents urine retention induced by intraspinal cord injection of colchicine in rats. Journal of the autonomic nervous system, 1990, Volume: 30 Suppl Topics: Analgesics; Animals; Benzeneacetamides; Benzomorphans; Colchicine; Eledoisin; Hypertrophy; Injections, Spinal; Naloxone; Pyrrolidines; Rats; Receptors, Opioid; Spinal Cord; Urinary Bladder; Urination	1990
Facilitation of memory retrieval by pretest morphine mediated by mu but not delta and kappa opioid receptors. Psychopharmacology, 1990, Volume: 102, Issue:3 Topics: Analgesics; Animals; Avoidance Learning; Benzeneacetamides; Electroshock; Male; Memory; Mice; Mice, Inbred Strains; Morphine; Naloxone; Oligopeptides; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu	1990
Kappa-opioid agonists do not inhibit adenylate cyclase. Journal of pharmacobio-dynamics, 1989, Volume: 12, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclase Inhibitors; Animals; Benzeneacetamides; Benzomorphans; Binding, Competitive; Brain; Cell Membrane; Enkephalin, Methionine; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Levorphanol; Morphine; Naloxone; Pentazocine; Pyrrolidines; Rana catesbeiana; Receptors, Opioid; Receptors, Opioid, kappa; Sodium Chloride	1989
Differential cardiovascular and respiratory responses to central administration of selective opioid agonists in conscious rabbits: correlation with receptor distribution. British journal of pharmacology, 1989, Volume: 98, Issue:3 Topics: Animals; Autoradiography; Behavior, Animal; Benzeneacetamides; Blood Glucose; Brain Chemistry; Catecholamines; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hemodynamics; Injections, Intraventricular; Medulla Oblongata; Naloxone; Narcotic Antagonists; Pyrrolidines; Rabbits; Receptors, Opioid; Respiration	1989
Opioids and hibernation. II. Effects of kappa opioid U69593 on induction of hibernation in summer-active ground squirrels by "hibernation induction trigger" (HIT). Life sciences, 1987, Nov-02, Volume: 41, Issue:18 Topics: Animals; Benzeneacetamides; Electric Stimulation; Female; Guinea Pigs; Hibernation; Ileum; Infusion Pumps; Male; Marmota; Muscle Contraction; Naloxone; Peptides; Proteins; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Sciuridae; Seasons	1987
Interaction of U-69,593 with mu-, alpha- and kappa-opioid binding sites and its analgesic and intestinal effects in rats. Life sciences, 1988, Volume: 42, Issue:3 Topics: Animals; Benzeneacetamides; Benzomorphans; Binding Sites; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Gastrointestinal Motility; In Vitro Techniques; Male; Naloxone; Nociceptors; Pyrrolidines; Rats; Receptors, Opioid	1988
Differential effects of mu and kappa opioid systems on motivational processes. NIDA research monograph, 1986, Volume: 75 Topics: Analgesics; Animals; Benzeneacetamides; Male; Morphine; Motivation; Naloxone; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reinforcement, Psychology	1986
Effect of mu- and kappa-opioid agonists on the electroconvulsive seizure threshold in mice and antagonism by naloxone and MR 2266. Pharmacology & toxicology, 1988, Volume: 62, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Benzodiazepines; Benzomorphans; Electroshock; Fentanyl; Male; Mice; Morphinans; Morphine; Nalbuphine; Naloxone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Seizures	1988
Motivational effects of opioids: influence of D-1 versus D-2 receptor antagonists. European journal of pharmacology, 1988, Jul-07, Volume: 151, Issue:2 Topics: Animals; Benzazepines; Benzeneacetamides; Conditioning, Psychological; Lithium; Male; Morphine; Motivation; Naloxone; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Opioid; Reinforcement, Psychology	1988
Involvement of beta-endorphin and mu-opioid receptors in mediating the aversive effect of lithium in the rat. European journal of pharmacology, 1988, Sep-13, Volume: 154, Issue:2 Topics: Analgesics; Animals; Benzeneacetamides; beta-Endorphin; Conditioning, Operant; Dexamethasone; Hypothalamus, Middle; Lithium; Male; Morphine; Naloxone; Pyrrolidines; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu	1988
[3H]U-69593 a highly selective ligand for the opioid kappa receptor. European journal of pharmacology, 1985, Feb-26, Volume: 109, Issue:2 Topics: Analgesics; Animals; Benzeneacetamides; Benzomorphans; Brain; Guinea Pigs; In Vitro Techniques; Ligands; Male; Mice; Naloxone; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa	1985
Effect of sodium ion on the affinity of naloxone for the kappa opioid receptor. Life sciences, 1987, Mar-16, Volume: 40, Issue:11 Topics: Animals; Benzeneacetamides; Binding, Competitive; Brain; Cations, Monovalent; Cell Membrane; Guinea Pigs; Naloxone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Sodium	1987
In vivo injection of antibodies directed against the cloned mu opioid receptor blocked supraspinal analgesia induced by mu-agonists in mice. Life sciences, 1995, Volume: 56, Issue:14 Topics: Amino Acid Sequence; Analgesia; Animals; Antibodies; Benzeneacetamides; beta-Endorphin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Immunization, Passive; Male; Mice; Molecular Sequence Data; Morphine; Naloxone; Peptide Fragments; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu	1995
kappa-Opioid receptor activates an inwardly rectifying K+ channel by a G protein-linked mechanism: coexpression in Xenopus oocytes. Molecular pharmacology, 1995, Volume: 47, Issue:5 Topics: Animals; Benzeneacetamides; Cloning, Molecular; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Gene Expression; GTP-Binding Proteins; In Vitro Techniques; Mice; Naloxone; Naltrexone; Oocytes; Pertussis Toxin; Potassium Channels; Pyrrolidines; Receptors, Opioid, kappa; RNA, Complementary; Virulence Factors, Bordetella; Xenopus	1995
Radioligand-binding study of noribogaine, a likely metabolite of ibogaine. Brain research, 1995, Mar-27, Volume: 675, Issue:1-2 Topics: Analgesics; Animals; Benzeneacetamides; Cattle; Cerebral Cortex; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ibogaine; In Vitro Techniques; Kinetics; Naloxone; Pyrrolidines; Radioligand Assay; Receptors, Opioid	1995
kappa-Opioid receptor-transfected cell lines: modulation of adenylyl cyclase activity following acute and chronic opioid treatments. FEBS letters, 1995, Mar-13, Volume: 361, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Animals; Benzeneacetamides; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Etorphine; GTP-Binding Proteins; Naloxone; Naltrexone; Opioid Peptides; Pertussis Toxin; Pyrrolidines; Receptors, Opioid, kappa; Virulence Factors, Bordetella	1995
The kappa opioid receptor expressed on the mouse R1.1 thymoma cell line down-regulates without desensitizing during chronic opioid exposure. The Journal of pharmacology and experimental therapeutics, 1995, Volume: 272, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Benzeneacetamides; Cell Membrane; Down-Regulation; In Vitro Techniques; Mice; Naloxone; Naltrexone; Pertussis Toxin; Pyrrolidines; Receptors, Opioid, kappa; Thymoma; Tumor Cells, Cultured; Virulence Factors, Bordetella	1995
Differential regulation of adenylyl cyclase activity by mu and delta opioids in rat caudate putamen and nucleus accumbens. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 267, Issue:1 Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Benzeneacetamides; Caudate Nucleus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Male; Molecular Sequence Data; Naloxone; Naltrexone; Nucleus Accumbens; Oligopeptides; Putamen; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Signal Transduction; Somatostatin	1993
Kappa opioids inhibit induction of long-term potentiation in the dentate gyrus of the guinea pig hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1994, Volume: 14, Issue:8 Topics: Animals; Benzeneacetamides; Dynorphins; Electric Stimulation; Guinea Pigs; Hippocampus; Long-Term Potentiation; Male; Naloxone; Naltrexone; Pyrrolidines; Receptors, Opioid, kappa; Synaptic Transmission	1994
Mu- and kappa-opioid receptors selectively reduce the same transient components of high-threshold calcium current in rat dorsal root ganglion sensory neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1994, Volume: 14, Issue:10 Topics: Analgesics; Animals; Benzeneacetamides; Calcium; Calcium Channels; Dynorphins; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Evoked Potentials; Ganglia, Spinal; In Vitro Techniques; Naloxone; Naltrexone; Narcotic Antagonists; Neurons, Afferent; Pyrrolidines; Rats; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reference Values; Sensitivity and Specificity	1994
Agonists and antagonists bind to different domains of the cloned kappa opioid receptor. Proceedings of the National Academy of Sciences of the United States of America, 1994, Aug-16, Volume: 91, Issue:17 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Base Sequence; Benzeneacetamides; Binding Sites; Cell Line; Chlorocebus aethiops; Cloning, Molecular; Colforsin; Cyclic AMP; Enkephalin, Leucine; Kinetics; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Naloxone; Naltrexone; Oligodeoxyribonucleotides; Protein Structure, Secondary; Pyrrolidines; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Recombinant Fusion Proteins; Recombinant Proteins; Transfection	1994
Antagonistic effects of the selective, competitive N-methyl-D-aspartate (NMDA) receptor antagonist, NPC 12626, on kappa opiate-induced analgesia in male deer mice. Brain research, 1994, Feb-21, Volume: 637, Issue:1-2 Topics: Amino Acids; Analgesics; Animals; Benzeneacetamides; Dizocilpine Maleate; Dose-Response Relationship, Drug; Male; Morphine; Naloxone; Naltrexone; Nociceptors; Pain Measurement; Peromyscus; Pyrrolidines; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa	1994
Functional evidence for multiple receptor activation by kappa-ligands in the inhibition of spinal nociceptive reflexes in the rat. British journal of pharmacology, 1993, Volume: 110, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Anticonvulsants; Benzeneacetamides; Benzofurans; Blood Pressure; Decerebrate State; Male; Naloxone; Nociceptors; Piperazines; Pyrroles; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Reflex; Spinal Cord; Thiophenes	1993
Inhibitory effects of NaCl and guanyl-5'yl-imidodiphosphate (GppNHp) on [3H]naloxone binding to kappa-opioid receptors in guinea pig cerebellum. Biological & pharmaceutical bulletin, 1993, Volume: 16, Issue:9 Topics: Animals; Benzeneacetamides; Binding Sites; Cerebellum; Cerebral Cortex; Corpus Striatum; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylmaleimide; Guanylyl Imidodiphosphate; Guinea Pigs; Male; Naloxone; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Sodium Chloride	1993
Selective opioid receptor agonists modulate mechanical allodynia in an animal model of neuropathic pain. Pain, 1993, Volume: 53, Issue:3 Topics: Analgesics; Animals; Benzeneacetamides; Benzomorphans; Disease Models, Animal; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain; Pain Measurement; Pain Threshold; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vocalization, Animal	1993
The NMDA receptor antagonist MK-801 differentially modulates mu and kappa opioid actions in spinal cord in vitro. Pain, 1996, Volume: 66, Issue:2-3 Topics: Analgesics; Animals; Animals, Newborn; Benzeneacetamides; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; In Vitro Techniques; Membrane Potentials; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord	1996
kappa-opioid receptor expression defines a phenotypically distinct subpopulation of astroglia: relationship to Ca2+ mobilization, development, and the antiproliferative effect of opioids. Brain research, 1996, Oct-21, Volume: 737, Issue:1-2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Astrocytes; Benzeneacetamides; Bromodeoxyuridine; Calcium; Calcium Channel Blockers; Cell Count; Cell Division; Cells, Cultured; DNA; Enzyme Inhibitors; Gene Expression Regulation, Developmental; Immunohistochemistry; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Nifedipine; Phenotype; Pyrrolidines; Receptors, Opioid, kappa; Thapsigargin; Time Factors	1996
Precipitated kappa-opioid receptor agonist withdrawal increase glutamate in rat locus coeruleus. European journal of pharmacology, 1996, Oct-31, Volume: 314, Issue:3 Topics: Analgesics; Analysis of Variance; Animals; Aspartic Acid; Benzeneacetamides; Butorphanol; Glutamic Acid; Injections, Intraventricular; Locus Coeruleus; Male; Microdialysis; Naloxone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Substance Withdrawal Syndrome	1996
Prevention by morphine of apomorphine- and oxytocin-induced penile erection and yawning: involvement of nitric oxide. Naunyn-Schmiedeberg's archives of pharmacology, 1997, Volume: 355, Issue:5 Topics: Analgesics, Opioid; Animals; Apomorphine; Benzeneacetamides; Dopamine Agonists; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Subcutaneous; Male; Microdialysis; Morphine; Naloxone; Narcotic Antagonists; Nitrates; Nitric Oxide; Nitrites; Oxytocin; Paraventricular Hypothalamic Nucleus; Penile Erection; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Yawning	1997
Comparison of the effects of a series of kappa-opioid receptor agonists upon sodium channel function in rat brain miniprisms. Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology, 1997, Volume: 117, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzeneacetamides; Benzomorphans; Brain; Disease Models, Animal; Inositol Phosphates; Naloxone; Pyrrolidines; Rats; Receptors, Opioid, kappa; Sodium Channels	1997
Dynorphin and the kappa 1 ligand [3H]U69,593 binding in the human epileptogenic hippocampus. Epilepsy research, 1997, Volume: 28, Issue:3 Topics: Adolescent; Adult; Benzeneacetamides; Binding Sites; Cell Count; Dynorphins; Epilepsy, Temporal Lobe; Female; Hippocampus; Humans; Male; Middle Aged; Naloxone; Neurons; Pyrrolidines; Receptors, Opioid, kappa; Tritium	1997
Kappa1- and kappa2-opioid receptors mediating presynaptic inhibition of dopamine and acetylcholine release in rat neostriatum. British journal of pharmacology, 1997, Volume: 122, Issue:3 Topics: Acetylcholine; Animals; Benzeneacetamides; Dopamine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; In Vitro Techniques; Male; N-Methylaspartate; Naloxone; Neostriatum; Neural Inhibition; Peptide Fragments; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu	1997
The effects of postmortem delay on mu, delta and kappa opioid receptor subtypes in rat brain and guinea pig cerebellum evaluated by radioligand receptor binding. Life sciences, 1997, Volume: 61, Issue:20 Topics: Animals; Benzeneacetamides; Brain; Cerebellum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Kinetics; Male; Naloxone; Postmortem Changes; Pyrrolidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium	1997
Prevention by morphine of N-methyl-D-aspartic acid-induced penile erection and yawning: involvement of nitric oxide. Brain research bulletin, 1997, Volume: 44, Issue:6 Topics: Animals; Behavior, Animal; Benzeneacetamides; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Male; Microdialysis; Morphine; N-Methylaspartate; Naloxone; Narcotic Antagonists; Narcotics; Nitric Oxide; Paraventricular Hypothalamic Nucleus; Penile Erection; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Yawning	1997
Affinity profiles of novel delta-receptor selective benzofuran derivatives of non-peptide opioids. Neurochemical research, 1998, Volume: 23, Issue:9 Topics: Animals; Benzeneacetamides; Benzofurans; Binding, Competitive; Brain; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Naloxone; Naltrexone; Oligopeptides; Oxycodone; Oxymorphone; Pyrrolidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Tritium	1998
Opioid efficacy in a C6 glioma cell line stably expressing the human kappa opioid receptor. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 288, Issue:2 Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Glioma; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Receptors, Opioid, kappa; Stereoisomerism; Transfection; Tritium; Tumor Cells, Cultured	1999
[A molecular mechanism for supersensitization of adenylyl cyclase system in cloned opioid receptor-transfected cells following sustained opioid treatment]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1998, Volume: 112 Suppl 1 Topics: Adenylyl Cyclases; Analgesics; Animals; Atropine; Benzeneacetamides; Carbachol; CHO Cells; Clone Cells; Cricetinae; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP Phosphohydrolases; Morphine; Muscarinic Agonists; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Transfection	1998
Morphine injected into the paraventricular nucleus of the hypothalamus prevents noncontact penile erections and impairs copulation: involvement of nitric oxide. The European journal of neuroscience, 1999, Volume: 11, Issue:6 Topics: Animals; Benzeneacetamides; Copulation; Female; Injections; Male; Morphine; Naloxone; Narcotic Antagonists; Nitric Oxide; Paraventricular Hypothalamic Nucleus; Penile Erection; Pyrrolidines; Rats; Rats, Sprague-Dawley; Sexual Behavior, Animal	1999
Supersensitization of the adenylyl cyclase system in Chinese hamster ovary cells co-expressing cloned opioid receptors and Gz, a PTX-insensitive G protein. Neuroscience letters, 1999, May-28, Volume: 267, Issue:2 Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Benzeneacetamides; CHO Cells; Cricetinae; Cyclic AMP; Enzyme Activation; Female; GTP-Binding Protein alpha Subunits; Heterotrimeric GTP-Binding Proteins; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pertussis Toxin; Pyrrolidines; Receptors, Opioid; Virulence Factors, Bordetella	1999
Receptor selectivity of Met-enkephalin-Arg6-Phe7, an endogenous opioid peptide, in cerebral cortex of human and rat. Life sciences, 2000, May-26, Volume: 67, Issue:1 Topics: Adult; Animals; Benzeneacetamides; Benzomorphans; Binding Sites; Cerebral Cortex; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Ethylketocyclazocine; Female; Humans; Male; Naloxone; Naltrexone; Norepinephrine; Oligopeptides; Peptide Fragments; Peptides; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Somatostatin	2000
Analgesic and antiinflammatory effects of two novel kappa-opioid peptides. Anesthesiology, 2001, Volume: 94, Issue:6 Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzeneacetamides; Dose-Response Relationship, Drug; Inflammation; Injections, Spinal; Male; Naloxone; Naltrexone; Narcotic Antagonists; Opioid Peptides; Pain Threshold; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa	2001
Morphine acutely and persistently attenuates nonvesicular GABA release in rat nucleus accumbens. Synapse (New York, N.Y.), 2001, Volume: 42, Issue:2 Topics: Analgesics; Animals; Benzeneacetamides; Carrier Proteins; Dopamine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Male; Morphine; Morphine Dependence; N-Methylaspartate; Naloxone; Neural Inhibition; Neurons; Nucleus Accumbens; Organ Culture Techniques; Pyrrolidines; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Tritium	2001
The effect of opioid agonists of delta-class DSLET, mu-class DAMGO, kappa-class U-69593 and an opioid antagonist, naloxone, on MTT activity of NALM-1 leukemic cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2002, Volume: 56, Issue:9 Topics: Benzeneacetamides; Cell Division; Cell Survival; Colorimetry; DNA Fragmentation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Humans; Leukemia; Naloxone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured	2002
Naloxone and its quaternary derivative, naloxone methiodide, have differing affinities for mu, delta, and kappa opioid receptors in mouse brain homogenates. Brain research, 2003, Feb-28, Volume: 964, Issue:2 Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Male; Mice; Naloxone; Narcotic Antagonists; Pyrrolidines; Quaternary Ammonium Compounds; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium	2003
Discriminative stimulus effects of acute morphine followed by naltrexone in the squirrel monkey. Psychopharmacology, 2003, Volume: 167, Issue:2 Topics: Animals; Benzeneacetamides; Conditioning, Operant; Dextrorphan; Discrimination Learning; Dose-Response Relationship, Drug; Generalization, Psychological; Levorphanol; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Receptors, Opioid; Saimiri; Substance Withdrawal Syndrome	2003
Morphine prevents glutamate-induced death of primary rat neonatal astrocytes through modulation of intracellular redox. Immunopharmacology and immunotoxicology, 2004, Volume: 26, Issue:1 Topics: Acetylcysteine; Animals; Animals, Newborn; Apoptosis; Astrocytes; Benzeneacetamides; Benzimidazoles; Bisbenzimidazole; Carbocyanines; Cell Line, Tumor; Cell Nucleus; Cell Survival; Cells, Cultured; Dizocilpine Maleate; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Glutamic Acid; Glutathione; Hydrogen Peroxide; Ion Channels; Microscopy, Fluorescence; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Morphine; Naloxone; Narcotic Antagonists; Neuroglia; Oxidation-Reduction; Oxidative Stress; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Rhodamine 123	2004
Kappa-opioid receptor-mediated effects of the plant-derived hallucinogen, salvinorin A, on inverted screen performance in the mouse. Behavioural pharmacology, 2005, Volume: 16, Issue:8 Topics: Analgesics, Opioid; Animals; Behavior, Animal; Benzeneacetamides; Diterpenes; Diterpenes, Clerodane; Hallucinogens; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Piperidines; Psychotropic Drugs; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Remifentanil	2005
A select set of opioid ligands induce up-regulation by promoting the maturation and stability of the rat kappa-opioid receptor in human embryonic kidney 293 cells. The Journal of pharmacology and experimental therapeutics, 2007, Volume: 323, Issue:2 Topics: Animals; Benzeneacetamides; Brefeldin A; Cells, Cultured; Cycloheximide; Diprenorphine; Humans; Ligands; Naloxone; Naltrexone; Pyrrolidines; Rats; Receptors, Opioid, kappa; RNA, Messenger; Transfection; Up-Regulation	2007
Activation of micro, delta or kappa opioid receptors by DAMGO, DPDPE, U-50488 or U-69593 respectively causes antinociception in the formalin test in the naked mole-rat (Heterocephalus glaber). Pharmacology, biochemistry, and behavior, 2009, Volume: 91, Issue:4 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Benzeneacetamides; Data Interpretation, Statistical; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Formaldehyde; Injections, Intraperitoneal; Male; Mole Rats; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Pyrrolidines; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu	2009
Morphine enhances microglial migration through modulation of P2X4 receptor signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, Jan-28, Volume: 29, Issue:4 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Benzeneacetamides; Calcium-Binding Proteins; Cell Movement; Cells, Cultured; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Inhibitors; Gene Expression Regulation; Microfilament Proteins; Microglia; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2X4; Signal Transduction; Time Factors	2009
Inhibition of motility in isolated horse small intestine is mediated by κ but not µ opioid receptors. Equine veterinary journal, 2012, Volume: 44, Issue:3 Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Dose-Response Relationship, Drug; Fentanyl; Gastrointestinal Motility; Horses; Intestine, Small; Male; Morphine; Naloxone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu	2012
Physical presence of nor-binaltorphimine in mouse brain over 21 days after a single administration corresponds to its long-lasting antagonistic effect on κ-opioid receptors. The Journal of pharmacology and experimental therapeutics, 2013, Volume: 346, Issue:3 Topics: Analgesics; Animals; Benzeneacetamides; Brain; Chromatography, High Pressure Liquid; Hot Temperature; Injections, Intraventricular; Membranes; Mice; Mice, Inbred C57BL; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Pyrrolidines; Receptors, Opioid, kappa; Reference Standards; Tandem Mass Spectrometry; Time Factors	2013
NOP receptor mediates anti-analgesia induced by agonist-antagonist opioids. Neuroscience, 2014, Jan-17, Volume: 257 Topics: Analgesics; Analysis of Variance; Animals; Benzeneacetamides; Dose-Response Relationship, Drug; Drug Interactions; Female; Male; Nalbuphine; Naloxone; Narcotic Antagonists; Nociceptin; Opioid Peptides; Pain Measurement; Pain Threshold; Protein Binding; Pyrrolidines; Rats; Rats, Sprague-Dawley; Sex Differentiation	2014
Differential effects of exercise on brain opioid receptor binding and activation in rats. Journal of neurochemistry, 2015, Volume: 132, Issue:2 Topics: Amygdala; Animals; Benzeneacetamides; Brain Chemistry; Cerebral Cortex; Electroshock; Enkephalin, D-Penicillamine (2,5)-; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Hypothalamus; Naloxone; Nerve Tissue Proteins; Opioid Peptides; Physical Conditioning, Animal; Protein Binding; Pyrrolidines; Rats; Receptors, Opioid; Signal Transduction; Time Factors	2015
Synthesis and pharmacological evaluation of [(3)H]HS665, a novel, highly selective radioligand for the kappa opioid receptor. ACS chemical neuroscience, 2015, Mar-18, Volume: 6, Issue:3 Topics: Analgesics; Analgesics, Opioid; Animals; Benzeneacetamides; Brain; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Guinea Pigs; Humans; Naloxone; Phenethylamines; Protein Binding; Pyrrolidines; Radioligand Assay; Receptors, Opioid, kappa; Time Factors; Transfection; Tritium	2015