Page last updated: 2024-08-26

u 69593 and morphine

u 69593 has been researched along with morphine in 103 studies

Research

Studies (103)

Timeframe	Studies, this research(%)	All Research%
pre-1990	10 (9.71)	18.7374
1990's	54 (52.43)	18.2507
2000's	21 (20.39)	29.6817
2010's	16 (15.53)	24.3611
2020's	2 (1.94)	2.80

Authors

Authors	Studies
Aldrich, JV; Caldwell, V; Choi, H; DeLander, GE; Murray, TF	1
Clark, CR; Halfpenny, PR; Hill, RG; Horwell, DC; Hughes, J; Jarvis, TC; Rees, DC; Schofield, D	1
Akil, H; Goldstein, A; Mansour, A; Meng, F; Thompson, RC; Watson, SJ; Xie, GX	1
Chen, Y; Liu, J; Mestek, A; Yu, L	1
Adapa, ID; Auh, JS; Berzetei-Gurske, IP; Brandt, SR; Craymer, K; Farrington, L; Haggart, D; Kennedy, JM; O'Brien, A; Polgar, WE; Rodriguez, L; Schwartz, RW; Toll, L; White, A	1
Anzini, M; Azzolina, O; Braile, C; Canullo, L; Cappelli, A; Collina, S; De Benedetti, PG; Galeotti, N; Gallelli, A; Ghelardini, C; Menziani, MC; Rizzo, M; Sbacchi, M; Vomero, S	1
Ananthan, S; Bartlett, JL; Bilsky, EJ; Davis, P; Dersch, CM; Khare, NK; Porreca, F; Rothman, RB; Saini, SK; Seitz, LE	1
Al-Ghananeem, AM; Butterfield, DA; Byrn, SR; Crooks, PA; Kottayil, SG	1
Fujii, H; Hirono, S; Nagase, H; Yamaotsu, N	1
Dersch, CM; Deschamps, JR; Iyer, MR; Jacobson, AE; Lee, YS; Rice, KC; Rothman, RB	1
Dersch, CM; Iyer, MR; Jacobson, AE; Rice, KC; Rothman, RB	2
Dersch, CM; Deschamps, JR; Jacobson, AE; Lim, HJ; Rice, KC; Rothman, RB	1
Journigan, VB; Khroyan, TV; Polgar, WE; Zaveri, NT	1
Bourgeois, C; Christoph, T; Englberger, W; Galla, F; Galla, HJ; Hüwel, S; Kögel, B; Lehmkuhl, K; Schepmann, D; Soeberdt, M; Straßburger, W; Torres-Gómez, H; Werfel, E; Wünsch, B	1
Abels, C; Aerts, SN; Autar, R; Bolster, MG; Bouzanne des Mazery, R; Frehland, B; Huang, TY; Knie, U; Lai, CC; Lin, KY; Lotts, T; Metze, D; Molenveld, P; Schepmann, D; Soeberdt, M; Ständer, S; Sterk, GJ; Storcken, RP; Tangherlini, G; van Holst, FR; Wagner, C; Wegert, A; Wünsch, B	1
Che, T; Kalinin, DV; Loser, K; Mykicki, N; Schepmann, D; Ständer, S; Tangherlini, G; Wünsch, B	1
Avery, BA; Behnke, M; Chear, NJ; Hiranita, T; Kamble, SH; León, F; McCurdy, CR; McMahon, LR; Obeng, S; Patel, A; Ramanathan, S; Reeves, ME; Restrepo, LF; Sharma, A	1
Chen, D; Fang, Q; Li, N; Niu, J; Shi, X; Shi, Y; Xiao, J; Xu, B; Xu, K; Zhang, M; Zhang, Q; Zhang, R	1
Dickenson, AH; Stanfa, LC; Sullivan, AF	1
Tai, KK; Wong, TM; Xia, Q	1
Argiolas, A; Gessa, GL; Melis, MR; Stancampiano, R	1
Dziedzicka, M; Lasoń, W; Przewłocka, B; Przewłocki, R	1
Mosberg, HI; Porreca, F; Vanderah, T; Wild, KD	1
Christensen, CB; Reiff, L	1
Agbas, A; Ahmed, MS; Cemerikic, B; Cheng, J	1
Bhargava, HN; Gulati, A; Rahmani, NH	1
Colpaert, FC; Millan, MJ	3
Cheng, J; Pasternak, GW; Paul, D; Pick, CG	1
Adler, MW; Eisenstein, TK; Geller, EB; Rogers, TJ; Taub, DD	1
Herz, A; Shippenberg, TS	4
Lasoń, W; Przewłocka, B; Sumová, A	1
Bettaney, J; Dray, A; James, IF; Ketchum, SB; Perkins, MN	1
Kaneto, H; Shiigi, Y; Takahashi, M	1
Green, J; Harris, S; Lloyd, P; Lozito, R; Messineo, E; Ossipov, MH	1
Bansinath, M; Puig, MM; Ramabadran, K; Turndorf, H	1
Makimura, M; Murakoshi, Y	1
Frey, HH	1
Herz, A; Millan, MJ; Mucha, RF; Shippenberg, TS	1
Herz, A; Huber, A; Millan, MJ; Shippenberg, TS; Stein, C	1
Ayesta, FJ; Emmett-Oglesby, MW; Herz, A; Shippenberg, TS	1
Garzón, J; Sánchez-Blázquez, P	1
Kuraishi, Y; Oyama, T; Satoh, M; Sugimoto, K; Ueda, M	1
Fowler, CJ; Fraser, GL	1
Mignat, C; Wille, U; Ziegler, A	1
Shoaib, M; Spanagel, R	1
Dykstra, LA; Pitts, RC	1
Hirokami, M; Matsumoto, M; Saito, H; Togashi, H; Yoshioka, M	1
Hirokami, M; Ikeda, T; Matsumoto, M; Saito, H; Smith, CB; Tochihara, M; Togashi, H; Yoshioka, M	1
Kavaliers, M; Saucier, DM	1
Holtzman, SG; Paronis, CA; Waddell, AB	1
Matsumoto, M; Saito, H; Smith, CB; Togashi, H; Yoshioka, M	1
Avidor-Reiss, T; Levy, R; Nevo, I; Pfeuffer, T; Vogel, Z	1
Chang, KJ; Li, LY	1
Archer, S; Bidlack, JM; Gatch, MB; Mello, NK; Negus, SS	1
Feng, J; Kendig, JJ	1
Jewett, DC; Mosberg, HI; Woods, JH	1
Archer, S; Bidlack, JM; Seyed-Mozaffari, A; Xu, JY	1
Catheline, G; Guilbaud, G; Idänpään-Heikkilä, JJ; Kayser, V	1
Ho, IK; Hoshi, K; Ma, T; Oh, S	1
Contarino, A; Drago, F; Giusti, P; Lipartiti, M; Natolino, F; Zanotti, A	1
Argiolas, A; Iannucci, U; Melis, MR; Succu, S	1
Argiolas, A; Melis, MR; Succu, S	1
Belcheva, MM; Bohn, LM; Coscia, CJ	2
LeFevour, A; Shippenberg, TS; Thompson, AC	1
Aynsley-Green, A; Dashwood, MR; Dickenson, AH; Fitzgerald, M; Rahman, W	1
Abdulla, FA; Smith, PA	1
Holtzman, SG; Waddell, AB	1
Minami, M; Nakagawa, T; Ozawa, T; Satoh, M; Watanabe, T	1
Argiolas, A; Melis, MR; Spano, MS; Succu, S	1
Minami, M; Nakagawa, T; Ozawa, T; Satoh, M	1
Dickenson, A; Fitzgerald, M; Hatch, D; Marsh, D	2
Holtzman, SG; Powell, KR	1
Inoue, M; Ueda, H	1
Horie, S; Ishihara, S; Murayama, T; Tsuchiya, S; Watanabe, K	1
Ananthan, S; Lu, YF; Rice, KC; Rothman, RB; Xu, H	1
Giannini, E; Improta, G; Lattanzi, R; Negri, L; Schmidhammer, H; Schutz, J	1
Schoffelmeer, AN; Vanderschuren, LJ; Wardeh, G	1
Jones, RM; Linsenmayer, DC; Mello, NK; Negus, SS; Portoghese, PS	1
Holtzman, SG; White, DA	1
Chen, XJ; Chi, ZQ; Dai, QY; Jin, WQ; Liu, ZH; Zhang, HP	1
Endoh, T; Fujimura, M; Izumimoto, N; Nagase, H; Suzuki, T; Takezawa, Y; Tanaka, T; Togashi, Y	1
Fields, HL; Hjelmstad, GO; Kim, JA; Pollak, KA	1
Choi, DH; Jung, EB; Kim, MS; Kim, TY; Lee, J; Moon, SK; Park, C; Park, R	1
Levendusky, MC; Levin, RM; Longhurst, PA; Matsumoto, S; Millington, WR	1
Fields, HL; Harasawa, I; Johansen, JP; Meng, ID	1
Beattie, DT; Cheruvu, M; Johnson-Rabidoux, S; Kaufman, E; Mai, N; O'Keefe, M; Peterson, C; Vickery, R	1
Banon, GP; Bernardi, MM; Felício, LF; Gil, IG; Teodorov, E; Tomita, AT	1
DeLeo, JA; Horvath, RJ	1
Cheng, K; Morrissey, EM; Negus, SS; Rice, KC; Rosenberg, M	1
Bertini, S; Menozzi, A; Poli, E; Pozzoli, C; Serventi, P; Zullian, C	1
Kalyuzhny, AE; Portoghese, PS; Yekkirala, AS	1
Banks, ML; Bowers, MS; Carlezon, WA; Cheng, K; Leitl, MD; Negus, SS; Onvani, S; Rice, KC	1
Kuo, A; Meutermans, W; Smith, MT; Wyse, BD	1
Altarifi, AA; Carroll, FI; Leitl, MD; Miller, LL; Neddenriep, B; Negus, SS	1
Abraham, AD; Burgeno, LM; Chavkin, C; Kuhar, JR; Land, BB; Ong, SE; Phillips, PEM; Reichard, KL; Schattauer, SS	1

Other Studies

103 other study(ies) available for u 69593 and morphine

Article	Year
N-terminal alkylated derivatives of [D-Pro10]dynorphin A-(1-11) are highly selective for kappa-opioid receptors. Journal of medicinal chemistry, 1992, Nov-27, Volume: 35, Issue:24 Topics: Alkylation; Amino Acid Sequence; Animals; Cerebellum; Dynorphins; Guinea Pigs; Ileum; Molecular Sequence Data; Peptide Fragments; Receptors, Opioid, kappa	1992
Highly selective kappa opioid analgesics. Synthesis and structure-activity relationships of novel N-[(2-aminocyclohexyl)aryl]acetamide and N-[(2-aminocyclohexyl)aryloxy]acetamide derivatives. Journal of medicinal chemistry, 1988, Volume: 31, Issue:4 Topics: Acetamides; Analgesics; Animals; Binding, Competitive; Cyclohexylamines; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Models, Molecular; Narcotics; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship	1988
Cloning and pharmacological characterization of a rat kappa opioid receptor. Proceedings of the National Academy of Sciences of the United States of America, 1993, Nov-01, Volume: 90, Issue:21 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Analgesics; Animals; Benzeneacetamides; Cell Line; Cell Membrane; Cloning, Molecular; Corpus Striatum; Cyclic AMP; DNA Primers; DNA, Complementary; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gene Library; In Situ Hybridization; Inositol 1,4,5-Trisphosphate; Kinetics; Ligands; Molecular Sequence Data; Pyrrolidines; Rats; Receptors, Opioid, kappa; Restriction Mapping; RNA, Messenger; Transfection	1993
Molecular cloning of a rat kappa opioid receptor reveals sequence similarities to the mu and delta opioid receptors. The Biochemical journal, 1993, Nov-01, Volume: 295 ( Pt 3) Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Benzomorphans; Cloning, Molecular; Diprenorphine; DNA, Complementary; Molecular Sequence Data; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sequence Analysis; Sequence Homology, Amino Acid; Transfection	1993
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications. NIDA research monograph, 1998, Volume: 178 Topics: Animals; Aorta, Thoracic; Cocaine; Cyclic AMP; Electric Stimulation; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Opioid-Related Disorders; Rats; Receptors, Dopamine; Receptors, Opioid; Receptors, Serotonin; Substance-Related Disorders	1998
Synthesis, biological evaluation, and receptor docking simulations of 2-[(acylamino)ethyl]-1,4-benzodiazepines as kappa-opioid receptor agonists endowed with antinociceptive and antiamnesic activity. Journal of medicinal chemistry, 2003, Aug-28, Volume: 46, Issue:18 Topics: Amino Acid Sequence; Analgesics; Animals; Avoidance Learning; Benzodiazepines; Cell Line; Cricetinae; Guinea Pigs; Humans; Ligands; Male; Mice; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Nootropic Agents; Pain Threshold; Radioligand Assay; Receptors, Opioid, kappa; Regression Analysis; Sequence Homology, Amino Acid; Stereoisomerism; Structure-Activity Relationship	2003
Identification of opioid ligands possessing mixed micro agonist/delta antagonist activity among pyridomorphinans derived from naloxone, oxymorphone, and hydromorphone [correction of hydropmorphone]. Journal of medicinal chemistry, 2004, Mar-11, Volume: 47, Issue:6 Topics: Analgesics; Animals; Binding Sites; Brain; Drug Tolerance; Electric Stimulation; Guinea Pigs; Hydromorphone; Ileum; In Vitro Techniques; Ligands; Male; Mice; Mice, Inbred ICR; Morphinans; Muscle Contraction; Muscle, Smooth; Naloxone; Oxymorphone; Pyridines; Radioligand Assay; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Vas Deferens	2004
Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners. Bioorganic & medicinal chemistry letters, 2006, Aug-15, Volume: 16, Issue:16 Topics: Animals; Codeine; Dihydromorphine; Esters; Guinea Pigs; Inhibitory Concentration 50; Kinetics; Ligands; Models, Chemical; Morphine; Protein Binding; Sulfates	2006
Identification of the three-dimensional pharmacophore of kappa-opioid receptor agonists. Bioorganic & medicinal chemistry, 2010, Jun-15, Volume: 18, Issue:12 Topics: Models, Chemical; Models, Molecular; Receptors, Opioid, kappa	2010
Probes for narcotic receptor mediated phenomena. 44. Synthesis of an N-substituted 4-hydroxy-5-(3-hydroxyphenyl)morphan with high affinity and selective μ-antagonist activity. European journal of medicinal chemistry, 2012, Volume: 50 Topics: Animals; Azabicyclo Compounds; CHO Cells; Cricetinae; Cricetulus; Crystallography, X-Ray; Guanosine 5'-O-(3-Thiotriphosphate); Molecular Structure; Morphinans; Narcotic Antagonists; Protein Binding; Receptors, Opioid; Receptors, Opioid, mu; Stereoisomerism; Structure-Activity Relationship	2012
Probes for narcotic receptor mediated phenomena. 47. Novel C4a- and N-substituted-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-6-ols. Bioorganic & medicinal chemistry, 2013, Jun-01, Volume: 21, Issue:11 Topics: Animals; Cell Membrane; CHO Cells; Cricetulus; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Molecular Structure; Narcotic Antagonists; Pyridines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship; Sulfur Radioisotopes; Tritium	2013
Probes for narcotic receptor mediated phenomena. 48. C7- and C8-substituted 5-phenylmorphan opioids from diastereoselective alkylation. European journal of medicinal chemistry, 2013, Volume: 67 Topics: Alkylation; Animals; Cells, Cultured; CHO Cells; Cricetulus; Crystallography, X-Ray; Dose-Response Relationship, Drug; Humans; Models, Molecular; Molecular Conformation; Morphinans; Receptors, Opioid; Stereoisomerism; Structure-Activity Relationship	2013
Designing bifunctional NOP receptor-mu opioid receptor ligands from NOP-receptor selective scaffolds. Part II. Bioorganic & medicinal chemistry, 2014, Apr-15, Volume: 22, Issue:8 Topics: Analgesics; Animals; Ligands; Mice; Models, Animal; Nociceptin Receptor; Pain; Piperidines; Protein Binding; Receptors, Opioid; Receptors, Opioid, mu; Structure-Activity Relationship	2014
Synthesis and pharmacological evaluation of 5-pyrrolidinylquinoxalines as a novel class of peripherally restricted κ-opioid receptor agonists. Journal of medicinal chemistry, 2014, Aug-14, Volume: 57, Issue:15 Topics: Analgesics, Opioid; Animals; Binding, Competitive; Blood-Brain Barrier; Brain; Endothelial Cells; Guinea Pigs; HEK293 Cells; Humans; Liver; Male; Mice; Models, Molecular; Pain Measurement; Permeability; Pyrrolidines; Quinoxalines; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma; Stereoisomerism; Structure-Activity Relationship	2014
Probes for narcotic receptor mediated phenomena 49. N-substituted rac-cis-4a-arylalkyl-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-6-ols. European journal of medicinal chemistry, 2015, Mar-06, Volume: 92 Topics: Benzofurans; Dose-Response Relationship, Drug; Heterocyclic Compounds, 3-Ring; Humans; Molecular Structure; Piperidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship	2015
Design and Synthesis of Enantiomerically Pure Decahydroquinoxalines as Potent and Selective κ-Opioid Receptor Agonists with Anti-Inflammatory Activity in Vivo. Journal of medicinal chemistry, 2017, 03-23, Volume: 60, Issue:6 Topics: Animals; Anti-Inflammatory Agents; Dermatitis; Drug Design; Guinea Pigs; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Quinoxalines; Rats, Wistar; Receptors, Opioid, kappa; Skin	2017
Development of Novel Quinoxaline-Based κ-Opioid Receptor Agonists for the Treatment of Neuroinflammation. Journal of medicinal chemistry, 2019, 01-24, Volume: 62, Issue:2 Topics: Animals; Antineoplastic Agents; Binding Sites; Encephalomyelitis, Autoimmune, Experimental; HEK293 Cells; Humans; Interferon-gamma; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Docking Simulation; Protein Structure, Tertiary; Quinoxalines; Receptors, Opioid, kappa; Signal Transduction; Structure-Activity Relationship; Th1 Cells	2019
Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. Journal of medicinal chemistry, 2020, 01-09, Volume: 63, Issue:1 Topics: Adrenergic Agents; Analgesics; Animals; Blood Proteins; CHO Cells; Cricetulus; Dopamine Agents; Guinea Pigs; Humans; Microsomes, Liver; Rats; Receptors, Adrenergic; Receptors, Opioid; Secologanin Tryptamine Alkaloids	2020
Development of Multifunctional and Orally Active Cyclic Peptide Agonists of Opioid/Neuropeptide FF Receptors that Produce Potent, Long-Lasting, and Peripherally Restricted Antinociception with Diminished Side Effects. Journal of medicinal chemistry, 2021, 09-23, Volume: 64, Issue:18 Topics: Analgesics, Opioid; Animals; Ligands; Male; Mice; Neuralgia; Peptides, Cyclic; Receptors, Neuropeptide	2021
Alterations in neuronal excitability and the potency of spinal mu, delta and kappa opioids after carrageenan-induced inflammation. Pain, 1992, Volume: 50, Issue:3 Topics: Animals; Benzeneacetamides; Carrageenan; Dose-Response Relationship, Drug; Injections, Spinal; Male; Morphine; Myelitis; Naloxone; Neurons; Oligopeptides; Palliative Care; Pyrrolidines; Rats; Rats, Sprague-Dawley	1992
Chronic morphine treatment increases the number, but decreases the affinity of [3H]-U69,593 binding sites in the rat heart. Life sciences, 1992, Volume: 50, Issue:16 Topics: Animals; Benzeneacetamides; Binding Sites; Body Temperature; Kinetics; Male; Morphine; Myocardium; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Time Factors	1992
Prevention by morphine of apomorphine- and oxytocin-induced penile erection and yawning: site of action in the brain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1992, Volume: 6, Issue:1 Topics: Analgesics; Animals; Apomorphine; Benzeneacetamides; Brain; Injections, Intraventricular; Male; Microinjections; Morphine; Naloxone; Narcotic Antagonists; Oxytocin; Paraventricular Hypothalamic Nucleus; Penile Erection; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Yawning	1992
Differential effects of opioid receptor agonists on nociception and cAMP level in the spinal cord of monoarthritic rats. Life sciences, 1992, Volume: 50, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Arthritis; Benzeneacetamides; Colforsin; Cyclic AMP; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guanylyl Imidodiphosphate; Injections, Spinal; Male; Morphine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord	1992
Opioid delta receptor subtypes are associated with different potassium channels. European journal of pharmacology, 1991, Jan-25, Volume: 193, Issue:1 Topics: Analgesics; Animals; Benzeneacetamides; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glyburide; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Oligopeptides; Potassium Channels; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Tetraethylammonium Compounds	1991
Morphine-6-glucuronide: receptor binding profile in bovine caudate nucleus. Pharmacology & toxicology, 1991, Volume: 68, Issue:2 Topics: Analgesics; Animals; Benzeneacetamides; Cattle; Caudate Nucleus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Kinetics; Morphine; Morphine Derivatives; Pyrrolidines; Receptors, Opioid	1991
Opioids regulate the release of human chorionic gonadotropin hormone from trophoblast tissue. Life sciences, 1991, Volume: 49, Issue:11 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Benzeneacetamides; Chorionic Gonadotropin; Endorphins; Female; Humans; Morphine; Naltrexone; Placenta; Pregnancy; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Trophoblasts	1991
Effects of morphine tolerance-dependence and abstinence on kappa-opiate receptors of rat brain and spinal cord. Biochemical pharmacology, 1991, Aug-22, Volume: 42, Issue:6 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Body Temperature Regulation; Brain; Drug Tolerance; Ethylketocyclazocine; Male; Morphine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Spinal Cord; Substance-Related Disorders; Time Factors	1991
Opioid systems in the response to inflammatory pain: sustained blockade suggests role of kappa- but not mu-opioid receptors in the modulation of nociception, behaviour and pathology. Neuroscience, 1991, Volume: 42, Issue:2 Topics: Analgesics; Animals; Behavior, Animal; Benzeneacetamides; Body Temperature; Body Weight; Inflammation; Male; Morphine; Naloxone; Nociceptors; Pain; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu	1991
Genetic influences in opioid analgesic sensitivity in mice. Brain research, 1991, Dec-06, Volume: 566, Issue:1-2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; Benzeneacetamides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mice; Mice, Inbred Strains; Morphine; Naloxone; Pain; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Species Specificity	1991
Immunomodulatory activity of mu- and kappa-selective opioid agonists. Proceedings of the National Academy of Sciences of the United States of America, 1991, Jan-15, Volume: 88, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Antibody Formation; Antibody-Producing Cells; Benzeneacetamides; Cells, Cultured; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Immunosuppression Therapy; Kinetics; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred Strains; Morphine; Naloxone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu	1991
Influence of chronic lithium treatment upon the motivational effects of opioids: alteration in the effects of mu- but not kappa-opioid receptor ligands. The Journal of pharmacology and experimental therapeutics, 1991, Volume: 256, Issue:3 Topics: Analgesics; Animals; Benzeneacetamides; beta-Endorphin; Conditioning, Operant; Drug Interactions; Lithium; Male; Morphine; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu	1991
The influence of conditioned fear-induced stress on the opioid systems in the rat. Pharmacology, biochemistry, and behavior, 1990, Volume: 37, Issue:4 Topics: Analgesia; Analgesics; Animals; Antipsychotic Agents; Benzeneacetamides; beta-Endorphin; Conditioning, Classical; Electroshock; Endorphins; Fear; Hypothalamus; In Vitro Techniques; Male; Morphine; Pituitary Gland; Protein Precursors; Pyrimidines; Pyrrolidines; Radioimmunoassay; Rats; Rats, Inbred Strains; Spinal Cord; Stress, Psychological	1990
Modification of nociception in a model of localized inflammatory pain by long-term administration of naloxone. Progress in clinical and biological research, 1990, Volume: 328 Topics: Animals; Benzeneacetamides; Disease Models, Animal; Inflammation; Male; Morphine; Mycobacterium Infections; Naloxone; Nociceptors; Pain; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid	1990
Opioid receptor ligands in the neonatal rat spinal cord: binding and in vitro depression of the nociceptive responses. British journal of pharmacology, 1990, Volume: 99, Issue:3 Topics: Animals; Animals, Newborn; Benzeneacetamides; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; In Vitro Techniques; Kinetics; Ligands; Morphine; Muscle, Smooth, Vascular; Naloxone; Narcotics; Nociceptors; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Spinal Cord	1990
The influence of sustained opioid receptor blockade in a model of long-term, localized inflammatory pain in rats. Neuroscience letters, 1990, May-18, Volume: 113, Issue:1 Topics: Analgesics; Animals; Benzeneacetamides; Drinking Behavior; Feeding Behavior; Inflammation; Male; Morphine; Naloxone; Pain; Pain Measurement; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu	1990
Facilitation of memory retrieval by pretest morphine mediated by mu but not delta and kappa opioid receptors. Psychopharmacology, 1990, Volume: 102, Issue:3 Topics: Analgesics; Animals; Avoidance Learning; Benzeneacetamides; Electroshock; Male; Memory; Mice; Mice, Inbred Strains; Morphine; Naloxone; Oligopeptides; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu	1990
Spinal antinociceptive synergy between clonidine and morphine, U69593, and DPDPE: isobolographic analysis. Life sciences, 1990, Volume: 47, Issue:16 Topics: Analgesics; Animals; Benzeneacetamides; Clonidine; Drug Synergism; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hot Temperature; Injections, Spinal; Male; Morphine; Pain; Pyrrolidines; Rats; Rats, Inbred Strains; Regression Analysis; Spinal Cord	1990
Hyperglycemia does not modify the pupillary effects of mu and kappa opiate agonists in mice. Journal of ocular pharmacology, 1989,Spring, Volume: 5, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Blood Glucose; Fentanyl; Half-Life; Hyperglycemia; Male; Mice; Morphine; Narcotics; Pupil; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu	1989
Kappa-opioid agonists do not inhibit adenylate cyclase. Journal of pharmacobio-dynamics, 1989, Volume: 12, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclase Inhibitors; Animals; Benzeneacetamides; Benzomorphans; Binding, Competitive; Brain; Cell Membrane; Enkephalin, Methionine; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Levorphanol; Morphine; Naloxone; Pentazocine; Pyrrolidines; Rana catesbeiana; Receptors, Opioid; Receptors, Opioid, kappa; Sodium Chloride	1989
Differential effects of mu and kappa opioid systems on motivational processes. NIDA research monograph, 1986, Volume: 75 Topics: Analgesics; Animals; Benzeneacetamides; Male; Morphine; Motivation; Naloxone; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reinforcement, Psychology	1986
Effect of mu- and kappa-opioid agonists on the electroconvulsive seizure threshold in mice and antagonism by naloxone and MR 2266. Pharmacology & toxicology, 1988, Volume: 62, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Benzodiazepines; Benzomorphans; Electroshock; Fentanyl; Male; Mice; Morphinans; Morphine; Nalbuphine; Naloxone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Seizures	1988
Motivational effects of opioids: influence of D-1 versus D-2 receptor antagonists. European journal of pharmacology, 1988, Jul-07, Volume: 151, Issue:2 Topics: Animals; Benzazepines; Benzeneacetamides; Conditioning, Psychological; Lithium; Male; Morphine; Motivation; Naloxone; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Opioid; Reinforcement, Psychology	1988
Involvement of beta-endorphin and mu-opioid receptors in mediating the aversive effect of lithium in the rat. European journal of pharmacology, 1988, Sep-13, Volume: 154, Issue:2 Topics: Analgesics; Animals; Benzeneacetamides; beta-Endorphin; Conditioning, Operant; Dexamethasone; Hypothalamus, Middle; Lithium; Male; Morphine; Naloxone; Pyrrolidines; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu	1988
Motivational effects of opioids in an animal model of prolonged inflammatory pain: alteration in the effects of kappa- but not of mu-receptor agonists. Pain, 1988, Volume: 35, Issue:2 Topics: Animals; Benzeneacetamides; Inflammation; Male; Morphine; Motivation; Narcotics; Pain; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu	1988
Place preference conditioning reveals the involvement of D1-dopamine receptors in the motivational properties of mu- and kappa-opioid agonists. Brain research, 1987, Dec-08, Volume: 436, Issue:1 Topics: Analgesics; Animals; Benzazepines; Benzeneacetamides; Conditioning, Psychological; Dopamine Antagonists; Male; Morphine; Motivation; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1	1987
Tolerance and selective cross-tolerance to the motivational effects of opioids. Psychopharmacology, 1988, Volume: 96, Issue:1 Topics: Analgesics; Animals; Benzeneacetamides; Choice Behavior; Conditioning, Operant; Dextroamphetamine; Drug Tolerance; Fentanyl; Male; Morphine; Motivation; Narcotics; Pyrrolidines; Rats; Rats, Inbred Strains	1988
In vivo injection of antibodies directed against the cloned mu opioid receptor blocked supraspinal analgesia induced by mu-agonists in mice. Life sciences, 1995, Volume: 56, Issue:14 Topics: Amino Acid Sequence; Analgesia; Animals; Antibodies; Benzeneacetamides; beta-Endorphin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Immunization, Passive; Male; Mice; Molecular Sequence Data; Morphine; Naloxone; Peptide Fragments; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu	1995
Opioidergic inhibition of capsaicin-evoked release of glutamate from rat spinal dorsal horn slices. Neuropharmacology, 1995, Volume: 34, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzeneacetamides; Capsaicin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glutamate Dehydrogenase; Glutamic Acid; In Vitro Techniques; Male; Morphine; Nerve Endings; Neurons, Afferent; Opioid Peptides; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord	1995
kappa-Opioid receptor recognition sites are not modulated by local anaesthetics. Biochemical pharmacology, 1995, Mar-30, Volume: 49, Issue:7 Topics: Anesthetics, Local; Animals; Benzeneacetamides; Binding Sites; Bupivacaine; Drug Synergism; Ethylketocyclazocine; Guinea Pigs; Morphine; Pyrrolidines; Rats; Receptors, Opioid, kappa; Tetracaine	1995
Affinity profiles of morphine, codeine, dihydrocodeine and their glucuronides at opioid receptor subtypes. Life sciences, 1995, Volume: 56, Issue:10 Topics: Animals; Benzeneacetamides; Binding, Competitive; Brain; Codeine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glucuronates; Guinea Pigs; Morphine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium	1995
Involvement of mesolimbic kappa-opioid systems in the discriminative stimulus effects of morphine. Neuroscience, 1994, Volume: 63, Issue:3 Topics: Analgesics; Animals; Benzeneacetamides; Brain Mapping; Cues; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Injections, Subcutaneous; Limbic System; Male; Morphine; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Reinforcement Schedule	1994
Antinociceptive and response rate-altering effects of kappa opioid agonists, spiradoline, enadoline and U69,593, alone and in combination with opioid antagonists in squirrel monkeys. The Journal of pharmacology and experimental therapeutics, 1994, Volume: 271, Issue:3 Topics: Analgesics; Animals; Azocines; Benzeneacetamides; Benzofurans; Dose-Response Relationship, Drug; Male; Morphine; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, kappa; Saimiri	1994
The functional role of opioid receptors in acetylcholine release in the rat adrenal medulla. European journal of pharmacology, 1994, Feb-21, Volume: 253, Issue:1-2 Topics: Acetylcholine; Adrenal Medulla; Animals; Benzeneacetamides; Chromatography, High Pressure Liquid; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Microdialysis; Morphine; Nerve Endings; Physostigmine; Potassium; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Splanchnic Nerves	1994
mu-Opioid receptors modulate noradrenaline release from the rat hippocampus as measured by brain microdialysis. Brain research, 1994, Feb-04, Volume: 636, Issue:1 Topics: Analgesics; Animals; Benzeneacetamides; Chromatography, High Pressure Liquid; Desipramine; Electrochemistry; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Extracellular Space; GTP-Binding Proteins; Hippocampus; Male; Microdialysis; Morphine; Naltrexone; Nerve Endings; Norepinephrine; Potassium; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, mu; Virulence Factors, Bordetella	1994
Antagonistic effects of the selective, competitive N-methyl-D-aspartate (NMDA) receptor antagonist, NPC 12626, on kappa opiate-induced analgesia in male deer mice. Brain research, 1994, Feb-21, Volume: 637, Issue:1-2 Topics: Amino Acids; Analgesics; Animals; Benzeneacetamides; Dizocilpine Maleate; Dose-Response Relationship, Drug; Male; Morphine; Naloxone; Naltrexone; Nociceptors; Pain Measurement; Peromyscus; Pyrrolidines; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa	1994
Naltrexone in vivo protects mu receptors from inactivation by beta-funaltrexamine, but not kappa receptors from inactivation by nor-binaltorphimine. Pharmacology, biochemistry, and behavior, 1993, Volume: 46, Issue:4 Topics: Analgesics; Animals; Benzeneacetamides; Cisterna Magna; Dose-Response Relationship, Drug; Injections; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu	1993
Opioid receptor regulation of 5-hydroxytryptamine release from the rat hippocampus measured by in vivo microdialysis. Brain research, 1993, Jun-04, Volume: 613, Issue:1 Topics: Analgesics; Animals; Benzeneacetamides; Dialysis; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hippocampus; Male; Micromanipulation; Morphine; Naltrexone; Potassium; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid; Serotonin	1993
Chronic opioid treatment induces adenylyl cyclase V superactivation. Involvement of Gbetagamma. The Journal of biological chemistry, 1996, Aug-30, Volume: 271, Issue:35 Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Analgesics; Animals; Benzeneacetamides; Cell Line; Chlorocebus aethiops; DNA, Complementary; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enzyme Activation; GTP-Binding Proteins; Morphine; Pertussis Toxin; Pyrrolidines; Receptors, Opioid, mu; Transfection; Virulence Factors, Bordetella	1996
The stimulatory effect of opioids on mitogen-activated protein kinase in Chinese hamster ovary cells transfected to express mu-opioid receptors. Molecular pharmacology, 1996, Volume: 50, Issue:3 Topics: Animals; Benzeneacetamides; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Cricetinae; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Etorphine; Morphine; Narcotics; Pertussis Toxin; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins; Transfection; Virulence Factors, Bordetella	1996
Effects of the structurally novel opioid 14 alpha, 14' beta-[dithiobis [(2-oxo-2,1-ethanediyl)imino]]bis(7,8-dihydromorphinone) on schedule-controlled behavior and thermal nociception in rhesus monkeys. The Journal of pharmacology and experimental therapeutics, 1996, Volume: 278, Issue:3 Topics: Analgesics; Animals; Azocines; Behavior, Animal; Benzeneacetamides; Female; Fentanyl; Hot Temperature; Hydromorphone; Macaca mulatta; Male; Morphine; Narcotic Antagonists; Pain; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu	1996
The NMDA receptor antagonist MK-801 differentially modulates mu and kappa opioid actions in spinal cord in vitro. Pain, 1996, Volume: 66, Issue:2-3 Topics: Analgesics; Animals; Animals, Newborn; Benzeneacetamides; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; In Vitro Techniques; Membrane Potentials; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord	1996
Discriminative stimulus effects of a centrally administered, delta-opioid peptide (D-Pen2-D-Pen5-enkephalin) in pigeons. Psychopharmacology, 1996, Volume: 127, Issue:3 Topics: Animals; Benzeneacetamides; Columbidae; Discrimination, Psychological; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Morphine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta	1996
N-cyclobutylmethyl analog of normorphinone, N-CBM-TAMO: a short-term opioid agonist and long-term Mu-selective irreversible opioid antagonist. The Journal of pharmacology and experimental therapeutics, 1996, Volume: 279, Issue:2 Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Cattle; Dose-Response Relationship, Drug; Hydromorphone; Male; Mice; Mice, Inbred ICR; Morphine; Narcotic Antagonists; Opioid-Related Disorders; Pyrrolidines; Receptors, Opioid, mu	1996
The antinociceptive activity of kappa- but not delta-opioid receptor agonists is maintained in morphine-tolerant neuropathic rats. European journal of pharmacology, 1996, Dec-30, Volume: 318, Issue:2-3 Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Drug Tolerance; Male; Morphine; Oligopeptides; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Vocalization, Animal	1996
Increased release of excitatory amino acids in rat locus coeruleus in kappa-opioid agonist dependent rats precipitated by nor-binaltorphimine. Brain research, 1997, Apr-04, Volume: 753, Issue:1 Topics: Animals; Benzeneacetamides; Butorphanol; Drug Evaluation, Preclinical; Excitatory Amino Acids; Locus Coeruleus; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Substance-Related Disorders	1997
Conditioned place preference: no tolerance to the rewarding properties of morphine. Naunyn-Schmiedeberg's archives of pharmacology, 1997, Volume: 355, Issue:5 Topics: Analysis of Variance; Animals; Behavior, Animal; Benzeneacetamides; Body Weight; Disease Models, Animal; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraperitoneal; Male; Morphine; Morphine Dependence; Narcotics; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu	1997
Prevention by morphine of apomorphine- and oxytocin-induced penile erection and yawning: involvement of nitric oxide. Naunyn-Schmiedeberg's archives of pharmacology, 1997, Volume: 355, Issue:5 Topics: Analgesics, Opioid; Animals; Apomorphine; Benzeneacetamides; Dopamine Agonists; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Subcutaneous; Male; Microdialysis; Morphine; Naloxone; Narcotic Antagonists; Nitrates; Nitric Oxide; Nitrites; Oxytocin; Paraventricular Hypothalamic Nucleus; Penile Erection; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Yawning	1997
Prevention by morphine of N-methyl-D-aspartic acid-induced penile erection and yawning: involvement of nitric oxide. Brain research bulletin, 1997, Volume: 44, Issue:6 Topics: Animals; Behavior, Animal; Benzeneacetamides; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Male; Microdialysis; Morphine; N-Methylaspartate; Naloxone; Narcotic Antagonists; Narcotics; Nitric Oxide; Paraventricular Hypothalamic Nucleus; Penile Erection; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Yawning	1997
Evidence for kappa- and mu-opioid receptor expression in C6 glioma cells. Journal of neurochemistry, 1998, Volume: 70, Issue:5 Topics: Analgesics; Analgesics, Opioid; Animals; Benzeneacetamides; beta-Endorphin; Binding, Competitive; Desipramine; Glioma; Morphine; Polymerase Chain Reaction; Pyrrolidines; Rats; Receptors, Opioid, kappa; Receptors, Opioid, mu; Transcription, Genetic; Tumor Cells, Cultured	1998
Sensitization to the conditioned rewarding effects of morphine and cocaine: differential effects of the kappa-opioid receptor agonist U69593. European journal of pharmacology, 1998, Mar-12, Volume: 345, Issue:1 Topics: Analgesics; Animals; Benzeneacetamides; Cocaine; Conditioning, Operant; Cues; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Morphine; Narcotics; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reward	1998
Postnatal development of multiple opioid receptors in the spinal cord and development of spinal morphine analgesia. Brain research. Developmental brain research, 1998, Jun-15, Volume: 108, Issue:1-2 Topics: Analgesics; Analgesics, Opioid; Animals; Autoradiography; Benzeneacetamides; Dose-Response Relationship, Drug; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Morphine; Nerve Fibers; Pyrrolidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord	1998
Axotomy reduces the effect of analgesic opioids yet increases the effect of nociceptin on dorsal root ganglion neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998, Dec-01, Volume: 18, Issue:23 Topics: Analgesics; Analgesics, Opioid; Animals; Axotomy; Benzeneacetamides; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Causalgia; Dihydropyridines; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ganglia, Spinal; Male; Morphine; Nerve Compression Syndromes; Neurons, Afferent; Nociceptin; omega-Conotoxin GVIA; Opioid Peptides; Peptides; Potassium; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sciatic Nerve; Sodium; Spinal Cord	1998
Modulation of cocaine-induced antinociception by opioid-receptor agonists. Pharmacology, biochemistry, and behavior, 1999, Volume: 62, Issue:2 Topics: Analgesics; Animals; Benzeneacetamides; Cocaine; Dose-Response Relationship, Drug; Drug Synergism; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Morphine; Pain; Pain Measurement; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, kappa	1999
[A molecular mechanism for supersensitization of adenylyl cyclase system in cloned opioid receptor-transfected cells following sustained opioid treatment]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1998, Volume: 112 Suppl 1 Topics: Adenylyl Cyclases; Analgesics; Animals; Atropine; Benzeneacetamides; Carbachol; CHO Cells; Clone Cells; Cricetinae; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP Phosphohydrolases; Morphine; Muscarinic Agonists; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Transfection	1998
Morphine injected into the paraventricular nucleus of the hypothalamus prevents noncontact penile erections and impairs copulation: involvement of nitric oxide. The European journal of neuroscience, 1999, Volume: 11, Issue:6 Topics: Animals; Benzeneacetamides; Copulation; Female; Injections; Male; Morphine; Naloxone; Narcotic Antagonists; Nitric Oxide; Paraventricular Hypothalamic Nucleus; Penile Erection; Pyrrolidines; Rats; Rats, Sprague-Dawley; Sexual Behavior, Animal	1999
Supersensitization of the adenylyl cyclase system in Chinese hamster ovary cells co-expressing cloned opioid receptors and Gz, a PTX-insensitive G protein. Neuroscience letters, 1999, May-28, Volume: 267, Issue:2 Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Benzeneacetamides; CHO Cells; Cricetinae; Cyclic AMP; Enzyme Activation; Female; GTP-Binding Protein alpha Subunits; Heterotrimeric GTP-Binding Proteins; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pertussis Toxin; Pyrrolidines; Receptors, Opioid; Virulence Factors, Bordetella	1999
Epidural opioid analgesia in infant rats I: mechanical and heat responses. Pain, 1999, Volume: 82, Issue:1 Topics: Analgesia, Epidural; Analgesics, Opioid; Animals; Animals, Newborn; Autoradiography; Benzeneacetamides; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Male; Morphine; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sensory Thresholds; Stress, Mechanical	1999
Epidural opioid analgesia in infant rats II: responses to carrageenan and capsaicin. Pain, 1999, Volume: 82, Issue:1 Topics: Analgesia, Epidural; Analgesics, Opioid; Animals; Animals, Newborn; Benzeneacetamides; Capsaicin; Carrageenan; Drug Evaluation, Preclinical; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Injections, Subcutaneous; Male; Morphine; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu	1999
Modulation of the discriminative stimulus effects of d-amphetamine by mu and kappa opioids in squirrel monkeys. Pharmacology, biochemistry, and behavior, 2000, Jan-01, Volume: 65, Issue:1 Topics: Animals; Benzeneacetamides; Benzofurans; Cocaine; Dextroamphetamine; Discrimination Learning; Dose-Response Relationship, Drug; Drug Interactions; Morphine; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Saimiri	2000
Mu-opioid agonist inhibition of kappa-opioid receptor-stimulated extracellular signal-regulated kinase phosphorylation is dynamin-dependent in C6 glioma cells. Journal of neurochemistry, 2000, Volume: 74, Issue:2 Topics: Animals; Benzeneacetamides; DNA; Dynamin I; Dynamins; Endothelins; Glioma; GTP Phosphohydrolases; Mitogen-Activated Protein Kinases; Morphine; Oligopeptides; Phosphatidylinositols; Phosphorylation; Pyrrolidines; Rats; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tumor Cells, Cultured	2000
Protein kinase C-mediated acute tolerance to peripheral mu-opioid analgesia in the bradykinin-nociception test in mice. The Journal of pharmacology and experimental therapeutics, 2000, Volume: 293, Issue:2 Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Blotting, Western; Bradykinin; Dose-Response Relationship, Drug; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enzyme Inhibitors; Male; Mice; Morphine; Nociceptors; Oligonucleotides, Antisense; Pain Measurement; Peripheral Nervous System; Protein Kinase C; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu	2000
Stimulatory effects of centrally injected kappa-opioid receptor agonists on gastric acid secretion in urethane-anesthetized rats. European journal of pharmacology, 2001, Apr-27, Volume: 418, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Anesthesia; Anesthetics, Intravenous; Animals; Benzeneacetamides; Deoxyglucose; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Gastric Acid; Gastric Mucosa; Injections, Intraventricular; Male; Morphine; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stomach; Time Factors; Urethane; Vagus Nerve	2001
SoRI 9409, a non-peptide opioid mu receptor agonist/delta receptor antagonist, fails to stimulate [35S]-GTP-gamma-S binding at cloned opioid receptors. Brain research bulletin, 2001, Jul-01, Volume: 55, Issue:4 Topics: Analgesics; Analgesics, Opioid; Animals; Benzamides; Benzeneacetamides; Binding, Competitive; CHO Cells; Cloning, Molecular; Cricetinae; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Iodine Radioisotopes; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Piperazines; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sulfur Radioisotopes; Tritium	2001
HS-599: a novel long acting opioid analgesic does not induce place-preference in rats. British journal of pharmacology, 2001, Volume: 134, Issue:2 Topics: Analgesics, Opioid; Animals; Behavior, Animal; Benzeneacetamides; Binding, Competitive; Buprenorphine; Dose-Response Relationship, Drug; Guinea Pigs; Ileum; Male; Membranes; Mice; Morphine; Oligopeptides; Pain; Pyrrolidines; Rabbits; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens	2001
Morphine acutely and persistently attenuates nonvesicular GABA release in rat nucleus accumbens. Synapse (New York, N.Y.), 2001, Volume: 42, Issue:2 Topics: Analgesics; Animals; Benzeneacetamides; Carrier Proteins; Dopamine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Male; Morphine; Morphine Dependence; N-Methylaspartate; Naloxone; Neural Inhibition; Neurons; Nucleus Accumbens; Organ Culture Techniques; Pyrrolidines; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Tritium	2001
Kappa opioid antagonist effects of the novel kappa antagonist 5'-guanidinonaltrindole (GNTI) in an assay of schedule-controlled behavior in rhesus monkeys. Psychopharmacology, 2002, Volume: 163, Issue:3-4 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Animals; Benzamides; Benzeneacetamides; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Female; Guanidines; Macaca mulatta; Male; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Piperazines; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Reinforcement Schedule; Time Factors	2002
Discriminative stimulus effects of acute morphine followed by naltrexone in the squirrel monkey. Psychopharmacology, 2003, Volume: 167, Issue:2 Topics: Animals; Benzeneacetamides; Conditioning, Operant; Dextrorphan; Discrimination Learning; Dose-Response Relationship, Drug; Generalization, Psychological; Levorphanol; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Receptors, Opioid; Saimiri; Substance Withdrawal Syndrome	2003
Opioid activity of C8813, a novel and potent opioid analgesic. Life sciences, 2003, May-30, Volume: 73, Issue:2 Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Cyclohexanols; Enkephalin, D-Penicillamine (2,5)-; Female; Fentanyl; Guinea Pigs; In Vitro Techniques; Male; Mice; Morphine; Pyrrolidines; Rabbits; Thiophenes	2003
Effect of repeated administration of TRK-820, a kappa-opioid receptor agonist, on tolerance to its antinociceptive and sedative actions. Brain research, 2004, Jan-09, Volume: 995, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzeneacetamides; Drug Tolerance; Male; Mice; Morphinans; Morphine; Motor Activity; Pain Measurement; Pyrrolidines; Receptors, Opioid, kappa; Spiro Compounds	2004
A single cocaine exposure enhances both opioid reward and aversion through a ventral tegmental area-dependent mechanism. Proceedings of the National Academy of Sciences of the United States of America, 2004, Apr-13, Volume: 101, Issue:15 Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Cocaine; Conditioning, Operant; Dizocilpine Maleate; Environment; Excitatory Amino Acid Antagonists; Male; Microinjections; Morphine; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reward; Ventral Tegmental Area	2004
Morphine prevents glutamate-induced death of primary rat neonatal astrocytes through modulation of intracellular redox. Immunopharmacology and immunotoxicology, 2004, Volume: 26, Issue:1 Topics: Acetylcysteine; Animals; Animals, Newborn; Apoptosis; Astrocytes; Benzeneacetamides; Benzimidazoles; Bisbenzimidazole; Carbocyanines; Cell Line, Tumor; Cell Nucleus; Cell Survival; Cells, Cultured; Dizocilpine Maleate; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Glutamic Acid; Glutathione; Hydrogen Peroxide; Ion Channels; Microscopy, Fluorescence; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Morphine; Naloxone; Narcotic Antagonists; Neuroglia; Oxidation-Reduction; Oxidative Stress; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Rhodamine 123	2004
Activation of mu opioid receptors in the ventrolateral periaqueductal gray inhibits reflex micturition in anesthetized rats. Neuroscience letters, 2004, Jun-10, Volume: 363, Issue:2 Topics: Administration, Intravesical; Anesthetics; Animals; Benzeneacetamides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Female; Microinjections; Morphine; Muscle Contraction; Narcotics; Periaqueductal Gray; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex; Sodium Chloride; Urinary Bladder; Urination	2004
Kappa opioids inhibit physiologically identified medullary pain modulating neurons and reduce morphine antinociception. Journal of neurophysiology, 2005, Volume: 93, Issue:3 Topics: Action Potentials; Analgesics, Opioid; Analysis of Variance; Animals; Benzeneacetamides; Drug Interactions; Male; Medulla Oblongata; Microinjections; Morphine; Neural Inhibition; Neurons; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa	2005
The in vitro pharmacology of the peripherally restricted opioid receptor antagonists, alvimopan, ADL 08-0011 and methylnaltrexone. Naunyn-Schmiedeberg's archives of pharmacology, 2007, Volume: 375, Issue:3 Topics: Analgesics, Opioid; Animals; Benzeneacetamides; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Naltrexone; Narcotic Antagonists; Oligopeptides; Piperidines; Pyrrolidines; Quaternary Ammonium Compounds; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins; Transfection	2007
Behavioral effects of acute stimulation of kappa-opioid receptors during lactation. Pharmacology, biochemistry, and behavior, 2008, Volume: 90, Issue:4 Topics: Analgesics, Opioid; Animals; Behavior, Animal; Benzeneacetamides; Blotting, Western; Female; Lactation; Morphine; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa	2008
Morphine enhances microglial migration through modulation of P2X4 receptor signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, Jan-28, Volume: 29, Issue:4 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Benzeneacetamides; Calcium-Binding Proteins; Cell Movement; Cells, Cultured; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Inhibitors; Gene Expression Regulation; Microfilament Proteins; Microglia; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2X4; Signal Transduction; Time Factors	2009
Effects of kappa opioids in an assay of pain-depressed intracranial self-stimulation in rats. Psychopharmacology, 2010, Volume: 210, Issue:2 Topics: Analgesics; Analgesics, Opioid; Animals; Benzeneacetamides; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Lactic Acid; Male; Medial Forebrain Bundle; Morphine; Naltrexone; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reinforcement, Psychology; Self Stimulation	2010
Inhibition of motility in isolated horse small intestine is mediated by κ but not µ opioid receptors. Equine veterinary journal, 2012, Volume: 44, Issue:3 Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Dose-Response Relationship, Drug; Fentanyl; Gastrointestinal Motility; Horses; Intestine, Small; Male; Morphine; Naloxone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu	2012
Standard opioid agonists activate heteromeric opioid receptors: evidence for morphine and [d-Ala(2)-MePhe(4)-Glyol(5)]enkephalin as selective μ-δ agonists. ACS chemical neuroscience, 2010, Feb-17, Volume: 1, Issue:2 Topics: Analgesics, Opioid; Area Under Curve; Benzeneacetamides; Calcium Signaling; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Guanosine 5'-O-(3-Thiotriphosphate); HEK293 Cells; Humans; Immunohistochemistry; Ligands; Morphine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu	2010
Pain-related depression of the mesolimbic dopamine system in rats: expression, blockade by analgesics, and role of endogenous κ-opioids. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014, Volume: 39, Issue:3 Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Depression; Disease Models, Animal; Dopamine; Gene Expression Regulation; Ketoprofen; Lactic Acid; Male; Medial Forebrain Bundle; Morphine; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Self Stimulation; Time Factors	2014
In vivo profiling of seven common opioids for antinociception, constipation and respiratory depression: no two opioids have the same profile. British journal of pharmacology, 2015, Volume: 172, Issue:2 Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Buprenorphine; Castor Oil; Constipation; Diarrhea; Enkephalin, D-Penicillamine (2,5)-; Fentanyl; Hot Temperature; Male; Morphine; Morphine Derivatives; Oxycodone; Pain; Pyrrolidines; Rats, Sprague-Dawley; Respiratory Insufficiency	2015
Effects of ketoprofen, morphine, and kappa opioids on pain-related depression of nesting in mice. Pain, 2015, Volume: 156, Issue:6 Topics: Analgesics, Opioid; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzeneacetamides; Depression; Dose-Response Relationship, Drug; Freund's Adjuvant; Ketoprofen; Male; Mice; Mice, Inbred ICR; Morphine; Nesting Behavior; Pain; Piperidines; Pyrrolidines; Receptors, Opioid, kappa; Tetrahydroisoquinolines	2015
Peroxiredoxin 6 mediates Gαi protein-coupled receptor inactivation by cJun kinase. Nature communications, 2017, 09-29, Volume: 8, Issue:1 Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Fentanyl; GTP-Binding Protein alpha Subunits, Gi-Go; JNK Mitogen-Activated Protein Kinases; Mice; Morphine; NADPH Oxidases; Peroxiredoxin VI; Phosphorylation; Pyrrolidines; Reactive Oxygen Species; Receptors, Dopamine D2; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu	2017