Compounds > u 69593
Page last updated: 2024-08-26

u 69593 and morphinans

u 69593 has been researched along with morphinans in 13 studies

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19905 (38.46)18.7374
1990's5 (38.46)18.2507
2000's3 (23.08)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Devlin, T; Shoemaker, WJ1
Berzetei-Gurske, I; Loew, GH1
Birchmore, B; Hughes, J; Hunter, JC; Woodruff, R1
Hill, RG; Hughes, J; Hunter, JC; Smith, JA1
Magnan, J; Pilapil, C; Quirion, R1
Frey, HH1
De Montis, GM; Devoto, P; Preti, A; Tagliamonte, A1
Archer, S; Bidlack, JM; McLaughlin, JP; Sebastian, A1
Eckhoff, B; Frenzen, G; Höfner, G; Klindert, T; Seitz, G; Stroetmann, I; Wanner, KT1
Mash, DC; Partilla, J; Rice, KC; Rothman, RB; Staley, JK1
Jones, RM; Linsenmayer, DC; Mello, NK; Negus, SS; Portoghese, PS1
Endoh, T; Fujimura, M; Izumimoto, N; Nagase, H; Suzuki, T; Takezawa, Y; Tanaka, T; Togashi, Y1
Leitermann, RJ; Mizoguchi, H; Nagase, H; Narita, M; Suzuki, T; Tseng, LF1

Other Studies

13 other study(ies) available for u 69593 and morphinans

ArticleYear
Characterization of kappa opioid binding using dynorphin A1-13 and U69,593 in the rat brain.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 253, Issue:2

    Topics: Analgesics; Animals; Benzeneacetamides; Benzomorphans; Binding, Competitive; Brain; Culture Techniques; Dynorphins; Ligands; Male; Morphinans; Peptide Fragments; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Tritium

1990
The novel antagonist profile of (-)metazocine.
    Progress in clinical and biological research, 1990, Volume: 328

    Topics: Animals; Benzeneacetamides; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Morphinans; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Vas Deferens

1990
Kappa opioid binding sites in the dog cerebral cortex and spinal cord.
    Neuroscience, 1989, Volume: 31, Issue:3

    Topics: Animals; Benzeneacetamides; Benzomorphans; Cerebral Cortex; Dogs; Morphinans; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Spinal Cord

1989
A kinetic analysis of kappa-opioid agonist binding using the selective radioligand [3H]U69593.
    Journal of neurochemistry, 1989, Volume: 53, Issue:1

    Topics: Animals; Benzeneacetamides; Benzomorphans; Binding, Competitive; Guinea Pigs; Kinetics; Male; Morphinans; Pyrrolidines; Radioligand Assay; Tritium

1989
Localization of kappa opioid receptor binding sites in human forebrain using [3H]U69,593: comparison with [3H]bremazocine.
    Cellular and molecular neurobiology, 1987, Volume: 7, Issue:3

    Topics: Autoradiography; Benzeneacetamides; Benzomorphans; Binding Sites; Brain; Humans; In Vitro Techniques; Morphinans; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Tissue Distribution

1987
Effect of mu- and kappa-opioid agonists on the electroconvulsive seizure threshold in mice and antagonism by naloxone and MR 2266.
    Pharmacology & toxicology, 1988, Volume: 62, Issue:3

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Benzodiazepines; Benzomorphans; Electroshock; Fentanyl; Male; Mice; Morphinans; Morphine; Nalbuphine; Naloxone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Seizures

1988
Differential effect of mu, delta, and kappa opioid agonists on adenylate cyclase activity.
    Journal of neuroscience research, 1987, Volume: 17, Issue:4

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclases; Analgesics; Animals; Benzeneacetamides; Benzomorphans; Corpus Striatum; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Male; Morphinans; Peptide Fragments; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid

1987
14 beta-Chlorocinnamoylamino derivatives of metopon: long-term mu-opioid receptor antagonists.
    European journal of pharmacology, 1997, Feb-12, Volume: 320, Issue:2-3

    Topics: Analgesics; Animals; Benzeneacetamides; Binding, Competitive; Cattle; Corpus Striatum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Kinetics; Male; Mice; Mice, Inbred ICR; Morphinans; Narcotic Antagonists; Nociceptors; Pain Measurement; Pyrrolidines; Receptors, Opioid, mu; Tritium

1997
Syntheses of novel pyridazinomorphinans by inverse electron demand cycloaddition and their binding to mu and kappa receptors.
    Archiv der Pharmazie, 1997, Volume: 330, Issue:6

    Topics: Animals; Benzeneacetamides; Binding, Competitive; Cattle; Cell Membrane; Corpus Striatum; Crystallography, X-Ray; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Indicators and Reagents; Models, Molecular; Molecular Structure; Morphinans; Pyrazines; Pyrrolidines; Radioligand Assay; Receptors, Opioid, kappa; Receptors, Opioid, mu

1997
Kappa2 opioid receptors in limbic areas of the human brain are upregulated by cocaine in fatal overdose victims.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997, Nov-01, Volume: 17, Issue:21

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adult; Amygdala; Benzeneacetamides; Benzomorphans; Binding, Competitive; Brain; Brain Chemistry; Caudate Nucleus; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Drug Overdose; Female; Fentanyl; Gyrus Cinguli; Humans; Isothiocyanates; Kinetics; Male; Morphinans; Protein Binding; Pyrrolidines; Receptors, Opioid, kappa; Tissue Distribution; Up-Regulation

1997
Kappa opioid antagonist effects of the novel kappa antagonist 5'-guanidinonaltrindole (GNTI) in an assay of schedule-controlled behavior in rhesus monkeys.
    Psychopharmacology, 2002, Volume: 163, Issue:3-4

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Animals; Benzamides; Benzeneacetamides; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Female; Guanidines; Macaca mulatta; Male; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Piperazines; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Reinforcement Schedule; Time Factors

2002
Effect of repeated administration of TRK-820, a kappa-opioid receptor agonist, on tolerance to its antinociceptive and sedative actions.
    Brain research, 2004, Jan-09, Volume: 995, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzeneacetamides; Drug Tolerance; Male; Mice; Morphinans; Morphine; Motor Activity; Pain Measurement; Pyrrolidines; Receptors, Opioid, kappa; Spiro Compounds

2004
Region-dependent G-protein activation by kappa-opioid receptor agonists in the mouse brain.
    Neuroscience letters, 2004, Feb-12, Volume: 356, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Brain; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Morphinans; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, kappa; Spiro Compounds

2004