u 69593 has been researched along with guanosine 5'-o-(3-thiotriphosphate) in 20 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (25.00) | 18.2507 |
| 2000's | 11 (55.00) | 29.6817 |
| 2010's | 4 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Blake, AD; Bot, G; Freeman, JC; Li, S; Reisine, T | 1 |
| Cheng, ZJ; Ma, L; Pei, G; Wu, YL; Yu, QM | 1 |
| Akil, H; Clark, MJ; Mansour, A; Medzihradsky, F; Remmers, AE; Woods, JH | 1 |
| Heyliger, SO; Jackson, C; Rice, KC; Rothman, RB | 1 |
| Andria, ML; Hiller, JM; Onoprishvili, I; Simon, EJ; Vilim, FS | 1 |
| Fukushima, N; Kohno, M; Ueda, H; Yoshida, A | 1 |
| Ho, IK; Jang, C; Ko, KH; Loh, HH; Ma, T; Park, Y; Tanaka, S | 1 |
| Balboni, G; Bryant, SD; Butterworth, J; Guerrini, R; Labarre, M; Lazarus, LH; Payza, K; Salvadori, S; Schmidhammer, H; St-Onge, S | 1 |
| Butelman, ER; Ko, MC; Kreek, MJ; Traynor, JR; Vivian, JA; Woods, JH | 1 |
| Ananthan, S; Lu, YF; Rice, KC; Rothman, RB; Xu, H | 1 |
| Leitermann, RJ; Mizoguchi, H; Nagase, H; Narita, M; Suzuki, T; Tseng, LF | 1 |
| Bart, G; Bidlack, JM; Borg, L; Ho, A; Kreek, MJ; Schluger, JH | 1 |
| Belcheva, MM; Clark, AL; Coscia, CJ; Hou, Y; Zahm, DS | 1 |
| Carroll, FI; Chaudhari, S; Deschamps, J; Gigstad, KM; Mascarella, SW; Navarro, HA; Thomas, JB | 1 |
| Beattie, DT; Cheruvu, M; Johnson-Rabidoux, S; Kaufman, E; Mai, N; O'Keefe, M; Peterson, C; Vickery, R | 1 |
| Galyean, R; Houghten, RA; Junien, JL; Lai, J; Largent-Milnes, T; Menzaghi, F; Porreca, F; Rivière, PJ; Schteingart, C; Stalewski, J; Sueiras-Diaz, J; Trojnar, J; Vanderah, TW; Wisniewski, K | 1 |
| Ho, A; Kreek, MJ; Piras, AP; Schlussman, SD; Zhou, Y | 1 |
| Kalyuzhny, AE; Portoghese, PS; Yekkirala, AS | 1 |
| Arida, RM; Brand, S; Cavalheiro, EA; de Almeida, AA; Gomes da Silva, S; Rocha, L; Zavala-Tecuapetla, C | 1 |
| Aubé, J; Bohn, LM; Frankowski, KJ; Lovell, KM; Prisinzano, TE; Stahl, EL; Zhou, L | 1 |
20 other study(ies) available for u 69593 and guanosine 5'-o-(3-thiotriphosphate)
| Article | Year |
|---|---|
Differential agonist regulation of the human kappa-opioid receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylate Cyclase Toxin; Benzeneacetamides; Cell Line; Cyclic AMP; Diprenorphine; Dynorphins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Levorphanol; Narcotic Antagonists; Narcotics; Pertussis Toxin; Pyrrolidines; Receptors, Opioid, kappa; Virulence Factors, Bordetella | 1997 |
Selective interference of beta-arrestin 1 with kappa and delta but not mu opioid receptor/G protein coupling.
Topics: Adenylyl Cyclase Inhibitors; Amino Acid Sequence; Analgesics; Arrestins; Benzeneacetamides; beta-Arrestin 1; beta-Arrestins; Cell Line; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins; Sequence Deletion; Transfection | 1998 |
Opioid efficacy in a C6 glioma cell line stably expressing the human kappa opioid receptor.
Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Glioma; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Receptors, Opioid, kappa; Stereoisomerism; Transfection; Tritium; Tumor Cells, Cultured | 1999 |
Opioid peptide receptor studies. 10. Nor-BNI differentially inhibits kappa receptor agonist-induced G-protein activation in the guinea pig caudate: further evidence of kappa receptor heterogeneity.
Topics: Animals; Benzeneacetamides; Benzodiazepines; Brain; Caudate Nucleus; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; In Vitro Techniques; Inhibitory Concentration 50; Naltrexone; Oligopeptides; Peptide Fragments; Peptides; Pyrrolidines; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin | 1999 |
The bovine mu-opioid receptor: cloning of cDNA and pharmacological characterization of the receptor expressed in mammalian cells.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Analgesics, Opioid; Animals; Base Sequence; Benzeneacetamides; Binding, Competitive; Cattle; Cell Line; Cell Membrane; Cloning, Molecular; Colforsin; Corpus Striatum; Diprenorphine; DNA, Complementary; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Gene Expression; Gene Expression Regulation; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Molecular Sequence Data; Pyrrolidines; Radioligand Assay; Receptors, Opioid, mu; Recombinant Fusion Proteins; Sequence Alignment; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Sulfur Radioisotopes; Tritium | 1999 |
G(i1) and G(oA) differentially determine kinetic efficacies of agonists for kappa-opioid receptor.
Topics: Animals; Benzeneacetamides; Binding, Competitive; Blotting, Western; Cell Line; Cell Membrane; Enzyme Activation; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Heterotrimeric GTP-Binding Proteins; Kinetics; Ligands; Magnesium; Narcotic Antagonists; Protein Binding; Pyrrolidines; Rats; Receptors, Opioid, kappa; Spodoptera; Thermodynamics; Transduction, Genetic | 2000 |
Comparison of G-protein activation in the brain by mu-, delta-, and kappa-opioid receptor agonists in mu-opioid receptor knockout mice.
Topics: Alleles; Analgesics, Opioid; Animals; Autoradiography; Benzeneacetamides; Binding, Competitive; Blotting, Southern; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sulfur Radioisotopes | 2000 |
Inverse agonism by Dmt-Tic analogues and HS 378, a naltrindole analogue.
Topics: Benzamides; Benzeneacetamides; Binding, Competitive; Cell Line; Cell Membrane; Dipeptides; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Isoquinolines; Naltrexone; Narcotic Antagonists; Piperazines; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sulfur Radioisotopes; Tetrahydroisoquinolines | 2000 |
GR89,696: a potent kappa-opioid agonist with subtype selectivity in rhesus monkeys.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Benzeneacetamides; Cerebral Cortex; Discrimination, Psychological; Diuresis; Ethylketocyclazocine; Female; Guanosine 5'-O-(3-Thiotriphosphate); Macaca mulatta; Male; Membranes; Muscle Relaxation; Naltrexone; Pain Measurement; Piperazines; Prolactin; Pyrrolidines; Radioligand Assay; Receptors, Opioid, kappa; Respiratory Mechanics | 2001 |
SoRI 9409, a non-peptide opioid mu receptor agonist/delta receptor antagonist, fails to stimulate [35S]-GTP-gamma-S binding at cloned opioid receptors.
Topics: Analgesics; Analgesics, Opioid; Animals; Benzamides; Benzeneacetamides; Binding, Competitive; CHO Cells; Cloning, Molecular; Cricetinae; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Iodine Radioisotopes; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Piperazines; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sulfur Radioisotopes; Tritium | 2001 |
Region-dependent G-protein activation by kappa-opioid receptor agonists in the mouse brain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Brain; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Morphinans; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, kappa; Spiro Compounds | 2004 |
Nalmefene induced elevation in serum prolactin in normal human volunteers: partial kappa opioid agonist activity?
Topics: Adolescent; Adult; Analgesics, Opioid; Animals; Benzeneacetamides; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Estradiol; Female; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Naltrexone; Narcotic Antagonists; Prolactin; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2005 |
Increased opioid receptor binding and G protein coupling in the accumbens and ventral tegmental area of postnatal day 2 rats.
Topics: Animals; Animals, Newborn; Autoradiography; Benzeneacetamides; Enkephalin, D-Penicillamine (2,5)-; Female; Guanosine 5'-O-(3-Thiotriphosphate); Nociceptin; Nociceptin Receptor; Nucleus Accumbens; Opioid Peptides; Pregnancy; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Opioid; Receptors, Opioid, mu; Ventral Tegmental Area | 2006 |
N-substituted cis-4a-(3-hydroxyphenyl)-8a-methyloctahydroisoquinolines are opioid receptor pure antagonists.
Topics: Animals; Benzeneacetamides; CHO Cells; Cricetinae; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Isoquinolines; Models, Molecular; Molecular Conformation; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2005 |
The in vitro pharmacology of the peripherally restricted opioid receptor antagonists, alvimopan, ADL 08-0011 and methylnaltrexone.
Topics: Analgesics, Opioid; Animals; Benzeneacetamides; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Naltrexone; Narcotic Antagonists; Oligopeptides; Piperidines; Pyrrolidines; Quaternary Ammonium Compounds; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins; Transfection | 2007 |
Novel D-amino acid tetrapeptides produce potent antinociception by selectively acting at peripheral kappa-opioid receptors.
Topics: Acetic Acid; Algorithms; Analgesics; Animals; Benzeneacetamides; Binding, Competitive; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Hot Temperature; Injections, Intravenous; Male; Mice; Mice, Inbred ICR; Oligopeptides; Opioid Peptides; Pain; Pain Measurement; Peripheral Nervous System; Postural Balance; Pyrrolidines; Radioligand Assay; Reaction Time; Receptors, Opioid, kappa | 2008 |
Acute withdrawal from chronic escalating-dose binge cocaine administration alters kappa opioid receptor stimulation of [35S] guanosine 5'-O-[gamma-thio]triphosphate acid binding in the rat ventral tegmental area.
Topics: Animals; Autoradiography; Benzeneacetamides; Cocaine; Guanosine 5'-O-(3-Thiotriphosphate); Male; Pyrrolidines; Radioligand Assay; Rats; Rats, Inbred F344; Receptors, Opioid, kappa; Substance Withdrawal Syndrome; Substantia Nigra; Ventral Tegmental Area | 2010 |
Standard opioid agonists activate heteromeric opioid receptors: evidence for morphine and [d-Ala(2)-MePhe(4)-Glyol(5)]enkephalin as selective μ-δ agonists.
Topics: Analgesics, Opioid; Area Under Curve; Benzeneacetamides; Calcium Signaling; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Guanosine 5'-O-(3-Thiotriphosphate); HEK293 Cells; Humans; Immunohistochemistry; Ligands; Morphine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2010 |
Differential effects of exercise on brain opioid receptor binding and activation in rats.
Topics: Amygdala; Animals; Benzeneacetamides; Brain Chemistry; Cerebral Cortex; Electroshock; Enkephalin, D-Penicillamine (2,5)-; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Hypothalamus; Naloxone; Nerve Tissue Proteins; Opioid Peptides; Physical Conditioning, Animal; Protein Binding; Pyrrolidines; Rats; Receptors, Opioid; Signal Transduction; Time Factors | 2015 |
Characterization of kappa opioid receptor mediated, dynorphin-stimulated [35S]GTPγS binding in mouse striatum for the evaluation of selective KOR ligands in an endogenous setting.
Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Corpus Striatum; Drug Evaluation, Preclinical; Dynorphins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice, Inbred C57BL; Mice, Knockout; Narcotic Antagonists; Protein Binding; Pyrrolidines; Receptors, Opioid, kappa; Signal Transduction; Sulfur Radioisotopes | 2015 |