Page last updated: 2024-08-26

u 69593 and enkephalin, d-penicillamine (2,5)-

u 69593 has been researched along with enkephalin, d-penicillamine (2,5)- in 104 studies

Research

Studies (104)

Timeframe	Studies, this research(%)	All Research%
pre-1990	4 (3.85)	18.7374
1990's	70 (67.31)	18.2507
2000's	21 (20.19)	29.6817
2010's	6 (5.77)	24.3611
2020's	3 (2.88)	2.80

Authors

Authors	Studies
Adapa, ID; Auh, JS; Berzetei-Gurske, IP; Brandt, SR; Craymer, K; Farrington, L; Haggart, D; Kennedy, JM; O'Brien, A; Polgar, WE; Rodriguez, L; Schwartz, RW; Toll, L; White, A	1
Bezawada, P; Coop, A; Cunningham, CW; Devereaux, AL; Griggs, NW; Healy, JR; Matsumoto, RR; Traynor, JR	1
Chadderdon, AM; Deschamps, JR; Hassan, SA; Jacobson, AE; Katz, JL; Kopajtic, TA; Lee, YS; Rice, KC; Traynor, JR; Truong, PM	1
Avery, BA; Behnke, M; Chear, NJ; Hiranita, T; Kamble, SH; León, F; McCurdy, CR; McMahon, LR; Obeng, S; Patel, A; Ramanathan, S; Reeves, ME; Restrepo, LF; Sharma, A	1
Chen, D; Fang, Q; Li, N; Niu, J; Shi, X; Shi, Y; Xiao, J; Xu, B; Xu, K; Zhang, M; Zhang, Q; Zhang, R	1
Fujii, H; Gouda, H; Higashi, E; Hirayama, S; Nagase, H; Tsumura, S; Uenohara, Y; Watanabe, Y	1
Gu, ZF; Jensen, RT; Maton, PN; Pradhan, T; Zhang, L	1
Borsodi, A; Búzás, B; Cavagnero, S; Hruby, VJ; Tóth, G	1
Green, IC; Khawaja, XZ	1
Kuemmerle, JF; Makhlouf, GM	1
Besse, D; Besson, JM; Lombard, MC; Perrot, S	1
Besse, D; Besson, JM; Butler, SH; Lombard, MC; Weil-Fugazza, J	1
Dziedzicka, M; Lasoń, W; Przewłocka, B; Przewłocki, R	1
Cometta-Morini, C; Kamal, J; Loew, G; Maguire, P; Tsai, N; Upton, C	1
Leslie, FM; Loughlin, SE; Smith, JA	1
Mosberg, HI; Porreca, F; Vanderah, T; Wild, KD	1
Christensen, CB; Reiff, L	1
Dissanayake, VU; Hughes, J; Hunter, JC	1
Elde, RP; Lacey, CB; Miller, KE; Seybold, VS; Stevens, CW	1
Bennett, GJ; Kajander, KC; Seybold, VS; Stevens, CW	1
Hauser, KF; Stiene-Martin, A	1
Imanishi, Y; Kimura, S; Sasaki-Yagi, Y	1
Enger, M; Grynne, BH; Holmen, AT; Maurset, AR	1
Berzetei-Gurske, I; Loew, GH	1
Bettaney, J; Dray, A; James, IF; Ketchum, SB; Perkins, MN	1
Magnan, J; Tiberi, M	2
Dissanayake, VU; Hill, RG; Hughes, J; Hunter, JC	1
Bourne, RC; Csillag, A; Stewart, MG	1
Green, J; Harris, S; Lloyd, P; Lozito, R; Messineo, E; Ossipov, MH	1
Dashwood, MR; Mathias, CJ; May, CN; Whitehead, CJ	1
Bastagli, L; Bernardi, P; Caldarera, CM; Guarnieri, C; Ventura, C	1
Carter, BD; Clark, MJ; Medzihradsky, F	1
Garzón, J; Sánchez-Blázquez, P	1
Archer, S; Bidlack, JM; Jiang, Q; Seyed-Mozaffari, A	1
Kuraishi, Y; Oyama, T; Satoh, M; Sugimoto, K; Ueda, M	1
Kuznetsov, A; Ma, GH; Miller, RJ; Philipson, LH	1
Glick, SD; Herrick-Davis, K; Pearl, SM; Teitler, M	1
Almeida, OF; Shippenberg, TS; Spanagel, R	1
Mignat, C; Wille, U; Ziegler, A	1
Búzás, B; Cox, BM; Izenwasser, S	1
Macdonald, RL; Moises, HC; Rusin, KI	1
Iwai, T; Luay, AE; Niwa, M; Nozaki, M; Tsurumi, K	1
Hirokami, M; Matsumoto, M; Saito, H; Togashi, H; Yoshioka, M	1
Bernstein, RN; Bilsky, EJ; Hruby, VJ; Lai, J; Pasternak, GW; Patel, D; Porreca, F	1
Glaum, SR; Miller, RJ; Rhim, H	1
Hirokami, M; Ikeda, T; Matsumoto, M; Saito, H; Smith, CB; Tochihara, M; Togashi, H; Yoshioka, M	1
Fukushima, N; Misu, Y; Miyamae, T; Ueda, H	1
Akil, H; Goldstein, A; Mansour, A; Meng, F; Thompson, RC; Watson, SJ; Xie, GX	1
Beatty, MF; Casy, AF; Kamal, JJ; Loew, GH; Maguire, PA; Perez, JJ; Rodriguez, L; Tsai, NF; Upton, C; Villar, HO	1
German, DC; Manaye, KF; Sadeq, M; Speciale, SG	1
Matsumoto, M; Saito, H; Smith, CB; Togashi, H; Yoshioka, M	1
Avidor-Reiss, T; Levy, R; Nevo, I; Pfeuffer, T; Vogel, Z	1
Chang, KJ; Li, LY	1
Jewett, DC; Mosberg, HI; Woods, JH	1
Demedts, MG; Dupont, LJ; Pype, JL; Verleden, GM	1
Obermeier, H; Schulz, R; Wehmeyer, A	1
Nelson, WL; Palmer, RB; Upthagrove, AL	1
Archer, S; Bidlack, JM; McLaughlin, JP; Sebastian, A	1
Caudle, RM; Dubner, R; Ho, J; Mannes, AJ	1
Bandler, R; Christie, MJ; Crowfoot, LJ; Floyd, NS; Henderson, LA; Keay, KA	1
Hogenboom, F; Mulder, AH; Schoffelmeer, AN	1
Bhargava, HN; Cortijo, J; Morcillo, EJ; Villar, VM	1
Avidor-Reiss, T; Barg, J; Belcheva, MM; Coscia, CJ; Ignatova, E; Levy, R; Vogel, Z; Young, EC; Zippel, R	1
Miller, RJ; Simen, AA	1
Aynsley-Green, A; Dashwood, MR; Dickenson, AH; Fitzgerald, M; Rahman, W	1
Borsodi, A; Hosztafi, S; Nevin, ST; Rónai, AZ; Spetea, M; Tóth, G	1
Lysle, DT; Schneider, GM	1
Cheng, ZJ; Ma, L; Pei, G; Wu, YL; Yu, QM	1
Abdulla, FA; Smith, PA	1
Holtzman, SG; Waddell, AB	1
Minami, M; Nakagawa, T; Ozawa, T; Satoh, M; Watanabe, T	1
Higashi, H; Kohno, T; Kumamoto, E; Shimoji, K; Yoshimura, M	1
Dickenson, A; Fitzgerald, M; Hatch, D; Marsh, D	2
Appleyard, SM; Celver, J; Chavkin, C; Kovoor, A; Pineda, V; Wayman, GA	1
Madamba, SG; Schweitzer, P; Siggins, GR	1
Andria, ML; Hiller, JM; Onoprishvili, I; Simon, EJ; Vilim, FS	1
Corbett, AD; Davies, MR; Glen, T; Menzies, JR; Paterson, SJ	1
Ho, IK; Jang, C; Ko, KH; Loh, HH; Ma, T; Park, Y; Tanaka, S	1
Cheong, YP; Cho, KP; Kim, CJ; Kim, JK; Kim, KW; Kwun, J; Woo, RS	1
Husbands, SM; Jales, AR; Lewis, JW	1
Eckert, WA; Light, AR; Willcockson, HH	1
Allen, CN; Grandy, DK; Ikeda, M; Nelson, CS; Shinagawa, H; Shinoe, T; Sugiyama, T; Yoshioka, T	1
Horie, S; Ishihara, S; Murayama, T; Tsuchiya, S; Watanabe, K	1
Gear, RW; Levine, JD; Schmidt, BL; Tambeli, CH	1
Newman, LC; Sands, SS; Stevens, CW; Wallace, DR	1
Irvine, RJ; Lewanowitsch, T	1
Chen, XJ; Chi, ZQ; Dai, QY; Jin, WQ; Liu, ZH; Zhang, HP	1
Bishop, MJ; Chang, KJ; Gengo, PJ; McNutt, R; O'Neill, SJ; Pettit, HO; Wei, K	1
Choi, DH; Jung, EB; Kim, MS; Kim, TY; Lee, J; Moon, SK; Park, C; Park, R	1
Levendusky, MC; Levin, RM; Longhurst, PA; Matsumoto, S; Millington, WR	1
Evans, AA; Smith, ME	1
Belcheva, MM; Clark, AL; Coscia, CJ; Hou, Y; Zahm, DS	1
Carroll, FI; Chaudhari, S; Deschamps, J; Gigstad, KM; Mascarella, SW; Navarro, HA; Thomas, JB	1
Grau, JW; Maultsby, ML; Puga, DA; Washburn, SN	1
Kohno, T	1
Funahashi, T; Ho, IK; Kimura, T; Shimizu, T; Watanabe, K; Yamamoto, I	1
Juma, F; Kanui, TI; Maloiy, GM; Olongida Ole Miaron, J; Towett, PK	1
Johnson, SM; Kinney, ME; Sladky, KK	1
Ansonoff, MA; Pintar, JE; Wen, T	1
Kalyuzhny, AE; Portoghese, PS; Yekkirala, AS	1
Kuo, A; Meutermans, W; Smith, MT; Wyse, BD	1
Arida, RM; Brand, S; Cavalheiro, EA; de Almeida, AA; Gomes da Silva, S; Rocha, L; Zavala-Tecuapetla, C	1

Reviews

1 review(s) available for u 69593 and enkephalin, d-penicillamine (2,5)-

Article	Year
[Opioids and spinal analgesia]. Masui. The Japanese journal of anesthesiology, 2007, Volume: 56 Suppl Topics: Analgesia, Epidural; Analgesics, Opioid; Animals; Benzeneacetamides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Humans; Nerve Fibers; Pain; Posterior Horn Cells; Pyrrolidines; Receptors, Opioid; Synapses; Synaptic Transmission	2007

Other Studies

103 other study(ies) available for u 69593 and enkephalin, d-penicillamine (2,5)-

Article	Year
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications. NIDA research monograph, 1998, Volume: 178 Topics: Animals; Aorta, Thoracic; Cocaine; Cyclic AMP; Electric Stimulation; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Opioid-Related Disorders; Rats; Receptors, Dopamine; Receptors, Opioid; Receptors, Serotonin; Substance-Related Disorders	1998
Benzylideneoxymorphone: A new lead for development of bifunctional mu/delta opioid receptor ligands. Bioorganic & medicinal chemistry letters, 2017, 02-01, Volume: 27, Issue:3 Topics: Analgesics; Animals; Benzylidene Compounds; Ligands; Mice; Oxymorphone; Pain; Receptors, Opioid, delta; Receptors, Opioid, mu	2017
Modulation of opioid receptor affinity and efficacy via N-substitution of 9β-hydroxy-5-(3-hydroxyphenyl)morphan: Synthesis and computer simulation study. Bioorganic & medicinal chemistry, 2017, 04-15, Volume: 25, Issue:8 Topics: Carbon-13 Magnetic Resonance Spectroscopy; Computer Simulation; Crystallography, X-Ray; Models, Molecular; Molecular Dynamics Simulation; Morphinans; Protein Binding; Proton Magnetic Resonance Spectroscopy; Receptors, Opioid; Spectrometry, Mass, Electrospray Ionization	2017
Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. Journal of medicinal chemistry, 2020, 01-09, Volume: 63, Issue:1 Topics: Adrenergic Agents; Analgesics; Animals; Blood Proteins; CHO Cells; Cricetulus; Dopamine Agents; Guinea Pigs; Humans; Microsomes, Liver; Rats; Receptors, Adrenergic; Receptors, Opioid; Secologanin Tryptamine Alkaloids	2020
Development of Multifunctional and Orally Active Cyclic Peptide Agonists of Opioid/Neuropeptide FF Receptors that Produce Potent, Long-Lasting, and Peripherally Restricted Antinociception with Diminished Side Effects. Journal of medicinal chemistry, 2021, 09-23, Volume: 64, Issue:18 Topics: Analgesics, Opioid; Animals; Ligands; Male; Mice; Neuralgia; Peptides, Cyclic; Receptors, Neuropeptide	2021
Morphinan derivatives with an oxabicyclo[3.2.1]octane structure as dual agonists toward δ and κ opioid receptors. Bioorganic & medicinal chemistry, 2022, 01-01, Volume: 53 Topics: Analgesics; Dose-Response Relationship, Drug; Humans; Molecular Structure; Morphinans; Receptors, Opioid, delta; Receptors, Opioid, kappa; Structure-Activity Relationship	2022
Characterization of opioid receptors on smooth muscle cells from guinea pig stomach. The American journal of physiology, 1992, Volume: 262, Issue:3 Pt 1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gastric Mucosa; Guinea Pigs; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Naloxone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Stomach	1992
Synthesis and binding characteristics of the highly delta-specific new tritiated opioid peptide, [3H]deltorphin II. Life sciences, 1992, Volume: 50, Issue:14 Topics: Analgesics; Animals; Benzeneacetamides; Brain; Cell Membrane; Dihydromorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Indicators and Reagents; Isotope Labeling; Kinetics; Oligopeptides; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium	1992
Studies on the effects of glucose in vitro and of the glycaemic state in vivo on the binding characteristics of mu, delta and kappa opiate receptors in mouse brain. Life sciences, 1992, Volume: 50, Issue:17 Topics: Animals; Benzeneacetamides; Binding, Competitive; Brain; Diabetes Mellitus, Experimental; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glucose; Ligands; Mice; Mice, Inbred C57BL; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Streptozocin	1992
Characterization of opioid receptors in intestinal muscle cells by selective radioligands and receptor protection. The American journal of physiology, 1992, Volume: 263, Issue:2 Pt 1 Topics: Animals; Benzeneacetamides; Cells, Cultured; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Intestinal Mucosa; Ligands; Muscle, Smooth; Osmolar Concentration; Pyrrolidines; Radioligand Assay; Receptors, Opioid; Temperature; Time Factors	1992
Regulation of opioid binding sites in the superficial dorsal horn of the rat spinal cord following loose ligation of the sciatic nerve: comparison with sciatic nerve section and lumbar dorsal rhizotomy. Neuroscience, 1992, Volume: 50, Issue:4 Topics: Analgesics; Animals; Autoradiography; Benzeneacetamides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Nerve Degeneration; Neurons, Afferent; Oligopeptides; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sciatic Nerve; Spinal Cord	1992
Monoarthritis induces complex changes in mu-, delta- and kappa-opioid binding sites in the superficial dorsal horn of the rat spinal cord. European journal of pharmacology, 1992, Nov-17, Volume: 223, Issue:2-3 Topics: Animals; Arthritis; Arthritis, Experimental; Autoradiography; Benzeneacetamides; Disease Models, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Freund's Adjuvant; Male; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord	1992
Differential effects of opioid receptor agonists on nociception and cAMP level in the spinal cord of monoarthritic rats. Life sciences, 1992, Volume: 50, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Arthritis; Benzeneacetamides; Colforsin; Cyclic AMP; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guanylyl Imidodiphosphate; Injections, Spinal; Male; Morphine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord	1992
Pharmacological profiles of fentanyl analogs at mu, delta and kappa opiate receptors. European journal of pharmacology, 1992, Mar-24, Volume: 213, Issue:2 Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Guinea Pigs; Ileum; Male; Mice; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens	1992
kappa-Opioid inhibition of [3H]dopamine release from rat ventral mesencephalic dissociated cell cultures. Molecular pharmacology, 1992, Volume: 42, Issue:4 Topics: Animals; Benzeneacetamides; Calcium; Cells, Cultured; Dopamine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Mesencephalon; Narcotics; Potassium; Pyrrolidines; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tetrodotoxin	1992
Opioid delta receptor subtypes are associated with different potassium channels. European journal of pharmacology, 1991, Jan-25, Volume: 193, Issue:1 Topics: Analgesics; Animals; Benzeneacetamides; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glyburide; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Oligopeptides; Potassium Channels; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Tetraethylammonium Compounds	1991
Morphine-6-glucuronide: receptor binding profile in bovine caudate nucleus. Pharmacology & toxicology, 1991, Volume: 68, Issue:2 Topics: Analgesics; Animals; Benzeneacetamides; Cattle; Caudate Nucleus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Kinetics; Morphine; Morphine Derivatives; Pyrrolidines; Receptors, Opioid	1991
Opioid binding sites in the guinea pig and rat kidney: radioligand homogenate binding and autoradiography. Molecular pharmacology, 1991, Volume: 40, Issue:1 Topics: Analgesics; Animals; Autoradiography; Benzeneacetamides; Binding, Competitive; Cations; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Guinea Pigs; Kidney; Kinetics; Narcotic Antagonists; Nucleotides; Pyrrolidines; Radioligand Assay; Rats; Receptors, Opioid; Receptors, Opioid, delta; Tritium	1991
Biochemical characterization and regional quantification of mu, delta and kappa opioid binding sites in rat spinal cord. Brain research, 1991, May-31, Volume: 550, Issue:1 Topics: Analgesics; Animals; Autoradiography; Benzeneacetamides; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Kinetics; Male; Pyrrolidines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Sufentanil; Tritium	1991
Bilateral and differential changes in spinal mu, delta and kappa opioid binding in rats with a painful, unilateral neuropathy. Pain, 1991, Volume: 46, Issue:3 Topics: Analgesics; Animals; Autoradiography; Behavior, Animal; Benzeneacetamides; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Ligands; Male; Nervous System Diseases; Pain; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sensory Thresholds; Spinal Cord; Sufentanil	1991
Glial growth is regulated by agonists selective for multiple opioid receptor types in vitro. Journal of neuroscience research, 1991, Volume: 29, Issue:4 Topics: Analgesics; Animals; Animals, Newborn; Astrocytes; Benzeneacetamides; Cells, Cultured; DNA Replication; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Glial Fibrillary Acidic Protein; Immunohistochemistry; Mice; Mice, Inbred ICR; Neuroglia; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thymidine	1991
Binding to opioid receptors of enkephalin derivatives taking alpha-helical conformation and its dimer. International journal of peptide and protein research, 1991, Volume: 38, Issue:4 Topics: Amino Acid Sequence; Animals; Benzeneacetamides; Brain Chemistry; Cattle; Cell Membrane; Cells, Cultured; Circular Dichroism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Kinetics; Ligands; Lipid Bilayers; Molecular Sequence Data; Pyrrolidines; Receptors, Opioid	1991
Effect of opioid agonists selective for three subclasses of opioid receptors and one sigma receptor agonist on dopamine stimulated adenylate cyclase in rat caudate nucleus. Pharmacology & toxicology, 1991, Volume: 69, Issue:5 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Animals; Benzeneacetamides; Caudate Nucleus; Cyclic AMP; Dopamine; Dopamine Antagonists; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid	1991
The novel antagonist profile of (-)metazocine. Progress in clinical and biological research, 1990, Volume: 328 Topics: Animals; Benzeneacetamides; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Morphinans; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Vas Deferens	1990
Opioid receptor ligands in the neonatal rat spinal cord: binding and in vitro depression of the nociceptive responses. British journal of pharmacology, 1990, Volume: 99, Issue:3 Topics: Animals; Animals, Newborn; Benzeneacetamides; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; In Vitro Techniques; Kinetics; Ligands; Morphine; Muscle, Smooth, Vascular; Naloxone; Narcotics; Nociceptors; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Spinal Cord	1990
Demonstration of the heterogeneity of the kappa-opioid receptors in guinea-pig cerebellum using selective and nonselective drugs. European journal of pharmacology, 1990, Jun-12, Volume: 188, Issue:6 Topics: Animals; Benzeneacetamides; Benzomorphans; Binding, Competitive; Cerebellum; Computers; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Guinea Pigs; In Vitro Techniques; Kinetics; Male; Membranes; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu	1990
Characterization of kappa-opioid receptors in the guinea-pig ileum. European journal of pharmacology, 1990, Jun-21, Volume: 182, Issue:1 Topics: Animals; Benzeneacetamides; Benzomorphans; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Kinetics; Muscle Contraction; Muscle, Smooth; Naloxone; Pyrroles; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Thiophenes	1990
Distribution of mu, delta, and kappa opioid receptor binding sites in the brain of the one-day-old domestic chick (Gallus domesticus): an in vitro quantitative autoradiographic study. The Journal of comparative neurology, 1990, Dec-15, Volume: 302, Issue:3 Topics: Analgesics; Animals; Autoradiography; Benzeneacetamides; Brain; Chickens; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Organ Specificity; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium	1990
Spinal antinociceptive synergy between clonidine and morphine, U69593, and DPDPE: isobolographic analysis. Life sciences, 1990, Volume: 47, Issue:16 Topics: Analgesics; Animals; Benzeneacetamides; Clonidine; Drug Synergism; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hot Temperature; Injections, Spinal; Male; Morphine; Pain; Pyrrolidines; Rats; Rats, Inbred Strains; Regression Analysis; Spinal Cord	1990
Evidence for the presence of mu- and kappa- but not of delta-opioid sites in the human fetal brain. Brain research. Developmental brain research, 1989, Feb-01, Volume: 45, Issue:2 Topics: Benzeneacetamides; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Kinetics; Male; Pyrrolidines; Radioligand Assay; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma	1989
Differential cardiovascular and respiratory responses to central administration of selective opioid agonists in conscious rabbits: correlation with receptor distribution. British journal of pharmacology, 1989, Volume: 98, Issue:3 Topics: Animals; Autoradiography; Behavior, Animal; Benzeneacetamides; Blood Glucose; Brain Chemistry; Catecholamines; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hemodynamics; Injections, Intraventricular; Medulla Oblongata; Naloxone; Narcotic Antagonists; Pyrrolidines; Rabbits; Receptors, Opioid; Respiration	1989
Opioid receptors in rat cardiac sarcolemma: effect of phenylephrine and isoproterenol. Biochimica et biophysica acta, 1989, Dec-11, Volume: 987, Issue:1 Topics: Analgesics; Animals; Benzeneacetamides; Bromides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hypotonic Solutions; Isoproterenol; Lithium; Lithium Compounds; Myocardium; Phenylephrine; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sarcolemma	1989
Selectivity of ligand binding to opioid receptors in brain membranes from the rat, monkey and guinea pig. European journal of pharmacology, 1988, Apr-13, Volume: 148, Issue:3 Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Brain Chemistry; Cell Membrane; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Guinea Pigs; Haplorhini; Pyrrolidines; Radioligand Assay; Rats; Receptors, Opioid; Sufentanil; Tritium	1988
In vivo injection of antibodies directed against the cloned mu opioid receptor blocked supraspinal analgesia induced by mu-agonists in mice. Life sciences, 1995, Volume: 56, Issue:14 Topics: Amino Acid Sequence; Analgesia; Animals; Antibodies; Benzeneacetamides; beta-Endorphin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Immunization, Passive; Male; Mice; Molecular Sequence Data; Morphine; Naloxone; Peptide Fragments; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu	1995
14 alpha,14' beta-[Dithiobis[(2-oxo-2,1-ethanediyl)imino]]bis (7,8-dihydromorphinone) and 14 alpha,14' beta-[dithiobis[(2-oxo-2,1- ethanediyl)imino]]bis[7,8-dihydro-N-(cyclopropylmethyl)normorphinone]: chemistry and opioid binding properties. Journal of medicinal chemistry, 1994, May-27, Volume: 37, Issue:11 Topics: Alkylation; Analgesics; Animals; Benzeneacetamides; Cattle; Cell Membrane; Corpus Striatum; Disulfides; Dithiothreitol; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hydromorphone; Kinetics; Molecular Structure; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tosylphenylalanyl Chloromethyl Ketone	1994
Opioidergic inhibition of capsaicin-evoked release of glutamate from rat spinal dorsal horn slices. Neuropharmacology, 1995, Volume: 34, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzeneacetamides; Capsaicin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glutamate Dehydrogenase; Glutamic Acid; In Vitro Techniques; Male; Morphine; Nerve Endings; Neurons, Afferent; Opioid Peptides; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord	1995
kappa-Opioid receptor activates an inwardly rectifying K+ channel by a G protein-linked mechanism: coexpression in Xenopus oocytes. Molecular pharmacology, 1995, Volume: 47, Issue:5 Topics: Animals; Benzeneacetamides; Cloning, Molecular; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Gene Expression; GTP-Binding Proteins; In Vitro Techniques; Mice; Naloxone; Naltrexone; Oocytes; Pertussis Toxin; Potassium Channels; Pyrrolidines; Receptors, Opioid, kappa; RNA, Complementary; Virulence Factors, Bordetella; Xenopus	1995
Radioligand-binding study of noribogaine, a likely metabolite of ibogaine. Brain research, 1995, Mar-27, Volume: 675, Issue:1-2 Topics: Analgesics; Animals; Benzeneacetamides; Cattle; Cerebral Cortex; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ibogaine; In Vitro Techniques; Kinetics; Naloxone; Pyrrolidines; Radioligand Assay; Receptors, Opioid	1995
Evidence that nor-binaltorphimine can function as an antagonist at multiple opioid receptor subtypes. European journal of pharmacology, 1994, Oct-24, Volume: 264, Issue:2 Topics: Amino Acid Sequence; Analgesics; Animals; Benzeneacetamides; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Injections, Intraventricular; Male; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Pain; Pain Threshold; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Somatostatin	1994
Affinity profiles of morphine, codeine, dihydrocodeine and their glucuronides at opioid receptor subtypes. Life sciences, 1995, Volume: 56, Issue:10 Topics: Animals; Benzeneacetamides; Binding, Competitive; Brain; Codeine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glucuronates; Guinea Pigs; Morphine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium	1995
Differential regulation of adenylyl cyclase activity by mu and delta opioids in rat caudate putamen and nucleus accumbens. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 267, Issue:1 Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Benzeneacetamides; Caudate Nucleus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Male; Molecular Sequence Data; Naloxone; Naltrexone; Nucleus Accumbens; Oligopeptides; Putamen; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Signal Transduction; Somatostatin	1993
Mu- and kappa-opioid receptors selectively reduce the same transient components of high-threshold calcium current in rat dorsal root ganglion sensory neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1994, Volume: 14, Issue:10 Topics: Analgesics; Animals; Benzeneacetamides; Calcium; Calcium Channels; Dynorphins; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Evoked Potentials; Ganglia, Spinal; In Vitro Techniques; Naloxone; Naltrexone; Narcotic Antagonists; Neurons, Afferent; Pyrrolidines; Rats; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reference Values; Sensitivity and Specificity	1994
Characterization of opioid receptors in the Mongolian gerbil cerebellum. Life sciences, 1994, Volume: 55, Issue:16 Topics: Animals; Autoradiography; Benzeneacetamides; Binding Sites; Binding, Competitive; Cerebellum; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gerbillinae; Guanylyl Imidodiphosphate; In Vitro Techniques; Narcotics; Pyrrolidines; Radioligand Assay; Receptors, Opioid; Receptors, Opioid, mu	1994
The functional role of opioid receptors in acetylcholine release in the rat adrenal medulla. European journal of pharmacology, 1994, Feb-21, Volume: 253, Issue:1-2 Topics: Acetylcholine; Adrenal Medulla; Animals; Benzeneacetamides; Chromatography, High Pressure Liquid; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Microdialysis; Morphine; Nerve Endings; Physostigmine; Potassium; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Splanchnic Nerves	1994
Selective inhibition of [D-Ala2, Glu4]deltorphin antinociception by supraspinal, but not spinal, administration of an antisense oligodeoxynucleotide to an opioid delta receptor. Life sciences, 1994, Volume: 55, Issue:2 Topics: Analgesics; Animals; Base Sequence; Benzeneacetamides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Molecular Sequence Data; Nociceptors; Oligonucleotides, Antisense; Oligopeptides; Pyrrolidines; Receptors, Opioid, delta	1994
Selective opioid agonists modulate afferent transmission in the rat nucleus tractus solitarius. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 264, Issue:2 Topics: Action Potentials; Afferent Pathways; Analgesics; Animals; Benzeneacetamides; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Medulla Oblongata; Potassium Channels; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Synaptic Transmission	1993
mu-Opioid receptors modulate noradrenaline release from the rat hippocampus as measured by brain microdialysis. Brain research, 1994, Feb-04, Volume: 636, Issue:1 Topics: Analgesics; Animals; Benzeneacetamides; Chromatography, High Pressure Liquid; Desipramine; Electrochemistry; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Extracellular Space; GTP-Binding Proteins; Hippocampus; Male; Microdialysis; Morphine; Naltrexone; Nerve Endings; Norepinephrine; Potassium; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, mu; Virulence Factors, Bordetella	1994
Delta opioid receptor mediates phospholipase C activation via Gi in Xenopus oocytes. FEBS letters, 1993, Nov-01, Volume: 333, Issue:3 Topics: Analgesics; Animals; Benzeneacetamides; Electric Conductivity; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Enzyme Activation; Female; Gene Expression; GTP-Binding Proteins; Membrane Potentials; Mice; Naltrexone; Narcotic Antagonists; Oocytes; Pyrrolidines; Receptors, Opioid, delta; Type C Phospholipases; Xenopus laevis	1993
Cloning and pharmacological characterization of a rat kappa opioid receptor. Proceedings of the National Academy of Sciences of the United States of America, 1993, Nov-01, Volume: 90, Issue:21 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Analgesics; Animals; Benzeneacetamides; Cell Line; Cell Membrane; Cloning, Molecular; Corpus Striatum; Cyclic AMP; DNA Primers; DNA, Complementary; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gene Library; In Situ Hybridization; Inositol 1,4,5-Trisphosphate; Kinetics; Ligands; Molecular Sequence Data; Pyrrolidines; Rats; Receptors, Opioid, kappa; Restriction Mapping; RNA, Messenger; Transfection	1993
Molecular mechanism of delta-selectivity of indole analogs of nonpeptide opioids. Molecular pharmacology, 1993, Volume: 44, Issue:6 Topics: Amino Acid Sequence; Animals; Benzeneacetamides; Binding Sites; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; In Vitro Techniques; Indoles; Molecular Sequence Data; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu	1993
Opioid receptors in midbrain dopaminergic regions of the rat. II. Kappa and delta receptor autoradiography. Journal of neural transmission. General section, 1993, Volume: 91, Issue:1 Topics: Animals; Autoradiography; Benzeneacetamides; Densitometry; Dopamine; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Image Processing, Computer-Assisted; Male; Mesencephalon; Neurons; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Substantia Nigra; Tegmentum Mesencephali	1993
Opioid receptor regulation of 5-hydroxytryptamine release from the rat hippocampus measured by in vivo microdialysis. Brain research, 1993, Jun-04, Volume: 613, Issue:1 Topics: Analgesics; Animals; Benzeneacetamides; Dialysis; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hippocampus; Male; Micromanipulation; Morphine; Naltrexone; Potassium; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid; Serotonin	1993
Chronic opioid treatment induces adenylyl cyclase V superactivation. Involvement of Gbetagamma. The Journal of biological chemistry, 1996, Aug-30, Volume: 271, Issue:35 Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Analgesics; Animals; Benzeneacetamides; Cell Line; Chlorocebus aethiops; DNA, Complementary; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enzyme Activation; GTP-Binding Proteins; Morphine; Pertussis Toxin; Pyrrolidines; Receptors, Opioid, mu; Transfection; Virulence Factors, Bordetella	1996
The stimulatory effect of opioids on mitogen-activated protein kinase in Chinese hamster ovary cells transfected to express mu-opioid receptors. Molecular pharmacology, 1996, Volume: 50, Issue:3 Topics: Animals; Benzeneacetamides; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Cricetinae; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Etorphine; Morphine; Narcotics; Pertussis Toxin; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins; Transfection; Virulence Factors, Bordetella	1996
Discriminative stimulus effects of a centrally administered, delta-opioid peptide (D-Pen2-D-Pen5-enkephalin) in pigeons. Psychopharmacology, 1996, Volume: 127, Issue:3 Topics: Animals; Benzeneacetamides; Columbidae; Discrimination, Psychological; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Morphine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta	1996
Opioids modulate the cholinergic contraction but not the nonadrenergic relaxation in guinea-pig airways in vitro. The European respiratory journal, 1996, Volume: 9, Issue:11 Topics: Animals; Benzeneacetamides; Cholinergic Fibers; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Trachea	1996
Expression of mu-, delta- and kappa-opioid receptors in baculovirus-infected insect cells. European journal of pharmacology, 1996, Dec-27, Volume: 318, Issue:1 Topics: Adenylyl Cyclases; Animals; Baculoviridae; Benzeneacetamides; Cell Line; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Insecta; Kinetics; Protein Binding; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins	1996
(E)- and (Z)-7-arylidenenaltrexones: synthesis and opioid receptor radioligand displacement assays. Journal of medicinal chemistry, 1997, Feb-28, Volume: 40, Issue:5 Topics: Animals; Benzeneacetamides; Benzomorphans; Benzylidene Compounds; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Magnetic Resonance Spectroscopy; Mass Spectrometry; Models, Molecular; Molecular Conformation; Molecular Structure; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, delta; Spectroscopy, Fourier Transform Infrared	1997
14 beta-Chlorocinnamoylamino derivatives of metopon: long-term mu-opioid receptor antagonists. European journal of pharmacology, 1997, Feb-12, Volume: 320, Issue:2-3 Topics: Analgesics; Animals; Benzeneacetamides; Binding, Competitive; Cattle; Corpus Striatum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Kinetics; Male; Mice; Mice, Inbred ICR; Morphinans; Narcotic Antagonists; Nociceptors; Pain Measurement; Pyrrolidines; Receptors, Opioid, mu; Tritium	1997
Putative kappa-2 opioid agonists are antihyperalgesic in a rat model of inflammation. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 281, Issue:1 Topics: Analgesics; Animals; Benzeneacetamides; Benzomorphans; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hyperalgesia; Male; Piperazines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa	1997
Cardiovascular effects of microinjections of opioid agonists into the 'Depressor Region' of the ventrolateral periaqueductal gray region. Brain research, 1997, Jul-11, Volume: 762, Issue:1-2 Topics: Analgesics; Animals; Benzeneacetamides; Blood Pressure; Bradycardia; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Excitatory Amino Acids; Heart Rate; Homocysteine; Hypertension; Hypotension; Male; Microinjections; Neural Inhibition; Pain; Periaqueductal Gray; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu	1997
Kappa1- and kappa2-opioid receptors mediating presynaptic inhibition of dopamine and acetylcholine release in rat neostriatum. British journal of pharmacology, 1997, Volume: 122, Issue:3 Topics: Acetylcholine; Animals; Benzeneacetamides; Dopamine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; In Vitro Techniques; Male; N-Methylaspartate; Naloxone; Neostriatum; Neural Inhibition; Peptide Fragments; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu	1997
Binding of [3H][D-Ala2, MePhe4, Gly-ol5] enkephalin, [3H][D-Pen2, D-Pen5]enkephalin, and [3H]U-69,593 to airway and pulmonary tissues of normal and sensitized rats. Peptides, 1997, Volume: 18, Issue:10 Topics: Animals; Asthma; Benzeneacetamides; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hypersensitivity, Immediate; Lung; Male; Protein Binding; Pulmonary Artery; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Respiratory System	1997
Opioid modulation of extracellular signal-regulated protein kinase activity is ras-dependent and involves Gbetagamma subunits. Journal of neurochemistry, 1998, Volume: 70, Issue:2 Topics: Animals; Benzeneacetamides; Calcium-Calmodulin-Dependent Protein Kinases; Chlorocebus aethiops; COS Cells; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Epidermal Growth Factor; GTP-Binding Proteins; Kinetics; Macromolecular Substances; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Pertussis Toxin; Pyrrolidines; ras Proteins; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins; Signal Transduction; Transfection; Virulence Factors, Bordetella	1998
Structural features determining differential receptor regulation of neuronal Ca channels. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998, May-15, Volume: 18, Issue:10 Topics: Analgesics; Barium; Benzeneacetamides; Calcium Channels; Cell Line; Electrophysiology; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Ion Channel Gating; Mutagenesis; Naltrexone; Narcotic Antagonists; Neurons; Protein Structure, Tertiary; Pyrrolidines; Receptors, Opioid, kappa; Recombinant Fusion Proteins; Transfection	1998
Postnatal development of multiple opioid receptors in the spinal cord and development of spinal morphine analgesia. Brain research. Developmental brain research, 1998, Jun-15, Volume: 108, Issue:1-2 Topics: Analgesics; Analgesics, Opioid; Animals; Autoradiography; Benzeneacetamides; Dose-Response Relationship, Drug; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Morphine; Nerve Fibers; Pyrrolidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord	1998
Affinity profiles of novel delta-receptor selective benzofuran derivatives of non-peptide opioids. Neurochemical research, 1998, Volume: 23, Issue:9 Topics: Animals; Benzeneacetamides; Benzofurans; Binding, Competitive; Brain; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Naloxone; Naltrexone; Oligopeptides; Oxycodone; Oxymorphone; Pyrrolidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Tritium	1998
Role of central mu-opioid receptors in the modulation of nitric oxide production by splenocytes. Journal of neuroimmunology, 1998, Aug-14, Volume: 89, Issue:1-2 Topics: Analgesics; Analgesics, Opioid; Animals; Bacterial Toxins; Benzeneacetamides; Cell Division; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enterotoxins; Enzyme Inhibitors; Injections, Intraventricular; Lymphocytes; Male; Naltrexone; Narcotic Antagonists; Neuroimmunomodulation; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Pyrrolidines; Quaternary Ammonium Compounds; Rats; Rats, Inbred Lew; Receptors, Opioid, mu; Spleen; Superantigens	1998
Selective interference of beta-arrestin 1 with kappa and delta but not mu opioid receptor/G protein coupling. The Journal of biological chemistry, 1998, Sep-18, Volume: 273, Issue:38 Topics: Adenylyl Cyclase Inhibitors; Amino Acid Sequence; Analgesics; Arrestins; Benzeneacetamides; beta-Arrestin 1; beta-Arrestins; Cell Line; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins; Sequence Deletion; Transfection	1998
Axotomy reduces the effect of analgesic opioids yet increases the effect of nociceptin on dorsal root ganglion neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998, Dec-01, Volume: 18, Issue:23 Topics: Analgesics; Analgesics, Opioid; Animals; Axotomy; Benzeneacetamides; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Causalgia; Dihydropyridines; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ganglia, Spinal; Male; Morphine; Nerve Compression Syndromes; Neurons, Afferent; Nociceptin; omega-Conotoxin GVIA; Opioid Peptides; Peptides; Potassium; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sciatic Nerve; Sodium; Spinal Cord	1998
Modulation of cocaine-induced antinociception by opioid-receptor agonists. Pharmacology, biochemistry, and behavior, 1999, Volume: 62, Issue:2 Topics: Analgesics; Animals; Benzeneacetamides; Cocaine; Dose-Response Relationship, Drug; Drug Synergism; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Morphine; Pain; Pain Measurement; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, kappa	1999
[A molecular mechanism for supersensitization of adenylyl cyclase system in cloned opioid receptor-transfected cells following sustained opioid treatment]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1998, Volume: 112 Suppl 1 Topics: Adenylyl Cyclases; Analgesics; Animals; Atropine; Benzeneacetamides; Carbachol; CHO Cells; Clone Cells; Cricetinae; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP Phosphohydrolases; Morphine; Muscarinic Agonists; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Transfection	1998
Actions of opioids on excitatory and inhibitory transmission in substantia gelatinosa of adult rat spinal cord. The Journal of physiology, 1999, Aug-01, Volume: 518 ( Pt 3) Topics: Animals; Benzeneacetamides; Electric Stimulation; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Evoked Potentials; Excitatory Postsynaptic Potentials; In Vitro Techniques; Male; Membrane Potentials; Opioid Peptides; Patch-Clamp Techniques; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Substantia Gelatinosa; Synaptic Transmission	1999
Epidural opioid analgesia in infant rats I: mechanical and heat responses. Pain, 1999, Volume: 82, Issue:1 Topics: Analgesia, Epidural; Analgesics, Opioid; Animals; Animals, Newborn; Autoradiography; Benzeneacetamides; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Male; Morphine; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sensory Thresholds; Stress, Mechanical	1999
Epidural opioid analgesia in infant rats II: responses to carrageenan and capsaicin. Pain, 1999, Volume: 82, Issue:1 Topics: Analgesia, Epidural; Analgesics, Opioid; Animals; Animals, Newborn; Benzeneacetamides; Capsaicin; Carrageenan; Drug Evaluation, Preclinical; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Injections, Subcutaneous; Male; Morphine; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu	1999
Agonist-dependent desensitization of the kappa opioid receptor by G protein receptor kinase and beta-arrestin. The Journal of biological chemistry, 1999, Aug-20, Volume: 274, Issue:34 Topics: Amino Acid Sequence; Animals; Arrestins; Benzeneacetamides; beta-Arrestin 2; beta-Arrestins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; G-Protein-Coupled Receptor Kinase 3; Molecular Sequence Data; Protein Serine-Threonine Kinases; Pyrrolidines; Rats; Receptor Protein-Tyrosine Kinases; Receptors, Opioid, kappa; Structure-Activity Relationship	1999
Dynorphin selectively augments the M-current in hippocampal CA1 neurons by an opiate receptor mechanism. Journal of neurophysiology, 1999, Volume: 82, Issue:4 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Hippocampus; In Vitro Techniques; Oligopeptides; Peptide Fragments; Potassium Channels; Pyramidal Cells; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa	1999
The bovine mu-opioid receptor: cloning of cDNA and pharmacological characterization of the receptor expressed in mammalian cells. Brain research. Molecular brain research, 1999, Nov-10, Volume: 73, Issue:1-2 Topics: Adenylyl Cyclases; Amino Acid Sequence; Analgesics, Opioid; Animals; Base Sequence; Benzeneacetamides; Binding, Competitive; Cattle; Cell Line; Cell Membrane; Cloning, Molecular; Colforsin; Corpus Striatum; Diprenorphine; DNA, Complementary; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Gene Expression; Gene Expression Regulation; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Molecular Sequence Data; Pyrrolidines; Radioligand Assay; Receptors, Opioid, mu; Recombinant Fusion Proteins; Sequence Alignment; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Sulfur Radioisotopes; Tritium	1999
In vitro agonist effects of nociceptin and [Phe(1)psi(CH(2)-NH)Gly(2)]nociceptin(1-13)NH(2) in the mouse and rat colon and the mouse vas deferens. European journal of pharmacology, 1999, Dec-03, Volume: 385, Issue:2-3 Topics: Animals; Benzeneacetamides; Benzofurans; Colon; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; In Vitro Techniques; Ligands; Male; Mice; Mice, Inbred DBA; Muscle Contraction; Narcotic Antagonists; Nociceptin; Nociceptin Receptor; Opioid Peptides; Peptide Fragments; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tetrodotoxin; Vas Deferens	1999
Comparison of G-protein activation in the brain by mu-, delta-, and kappa-opioid receptor agonists in mu-opioid receptor knockout mice. Brain research bulletin, 2000, Jul-01, Volume: 52, Issue:4 Topics: Alleles; Analgesics, Opioid; Animals; Autoradiography; Benzeneacetamides; Binding, Competitive; Blotting, Southern; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sulfur Radioisotopes	2000
Receptor selectivity of Met-enkephalin-Arg6-Phe7, an endogenous opioid peptide, in cerebral cortex of human and rat. Life sciences, 2000, May-26, Volume: 67, Issue:1 Topics: Adult; Animals; Benzeneacetamides; Benzomorphans; Binding Sites; Cerebral Cortex; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Ethylketocyclazocine; Female; Humans; Male; Naloxone; Naltrexone; Norepinephrine; Oligopeptides; Peptide Fragments; Peptides; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Somatostatin	2000
Selective kappa-opioid antagonists related to naltrindole. Effect of side-chain spacer in the 5'-amidinoalkyl series. Bioorganic & medicinal chemistry letters, 2000, Oct-16, Volume: 10, Issue:20 Topics: Amidines; Animals; Benzeneacetamides; Binding, Competitive; Brain; Cell Membrane; Drug Design; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Guinea Pigs; Indicators and Reagents; Kinetics; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, kappa; Structure-Activity Relationship	2000
Interference of biocytin with opioid-evoked hyperpolarization and membrane properties of rat spinal substantia gelatinosa neurons. Neuroscience letters, 2001, Jan-12, Volume: 297, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Benzeneacetamides; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Lysine; Membrane Potentials; Organ Culture Techniques; Patch-Clamp Techniques; Pyrrolidines; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Substantia Gelatinosa	2001
Cyclic AMP regulates the calcium transients released from IP(3)-sensitive stores by activation of rat kappa-opioid receptors expressed in CHO cells. Cell calcium, 2001, Volume: 29, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 8-Bromo Cyclic Adenosine Monophosphate; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Benzeneacetamides; Bucladesine; Calcium; Calcium Signaling; CHO Cells; Cloning, Molecular; Colforsin; Cricetinae; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enzyme Inhibitors; Gene Expression; Inositol 1,4,5-Trisphosphate; Peptides; Pyrrolidines; Rats; Receptors, Opioid, kappa; Thionucleotides; Transfection	2001
Stimulatory effects of centrally injected kappa-opioid receptor agonists on gastric acid secretion in urethane-anesthetized rats. European journal of pharmacology, 2001, Apr-27, Volume: 418, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Anesthesia; Anesthetics, Intravenous; Animals; Benzeneacetamides; Deoxyglucose; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Gastric Acid; Gastric Mucosa; Injections, Intraventricular; Male; Morphine; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stomach; Time Factors; Urethane; Vagus Nerve	2001
mu/delta Cooperativity and opposing kappa-opioid effects in nucleus accumbens-mediated antinociception in the rat. The European journal of neuroscience, 2002, Volume: 15, Issue:5 Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Capsaicin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Male; Narcotic Antagonists; Neurons; Nociceptors; Nucleus Accumbens; Pain; Pyrrolidines; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex	2002
Characterization of mu, kappa, and delta opioid binding in amphibian whole brain tissue homogenates. The Journal of pharmacology and experimental therapeutics, 2002, Volume: 301, Issue:1 Topics: Animals; Benzeneacetamides; Binding, Competitive; Brain Chemistry; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; In Vitro Techniques; Kinetics; Membranes; Pyrrolidines; Radioligand Assay; Rana pipiens; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu	2002
Naloxone and its quaternary derivative, naloxone methiodide, have differing affinities for mu, delta, and kappa opioid receptors in mouse brain homogenates. Brain research, 2003, Feb-28, Volume: 964, Issue:2 Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Male; Mice; Naloxone; Narcotic Antagonists; Pyrrolidines; Quaternary Ammonium Compounds; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium	2003
Opioid activity of C8813, a novel and potent opioid analgesic. Life sciences, 2003, May-30, Volume: 73, Issue:2 Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Cyclohexanols; Enkephalin, D-Penicillamine (2,5)-; Female; Fentanyl; Guinea Pigs; In Vitro Techniques; Male; Mice; Morphine; Pyrrolidines; Rabbits; Thiophenes	2003
DPI-3290 [(+)-3-((alpha-R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide]. I. A mixed opioid agonist with potent antinociceptive activity. The Journal of pharmacology and experimental therapeutics, 2003, Volume: 307, Issue:3 Topics: Analgesics; Animals; Benzamides; Benzeneacetamides; Binding, Competitive; Blood Gas Analysis; Brain Chemistry; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Guinea Pigs; Ileum; Male; Muscle, Smooth; Narcotic Antagonists; Narcotics; Pain Measurement; Piperazines; Pyrrolidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stereoisomerism; Vas Deferens	2003
Morphine prevents glutamate-induced death of primary rat neonatal astrocytes through modulation of intracellular redox. Immunopharmacology and immunotoxicology, 2004, Volume: 26, Issue:1 Topics: Acetylcysteine; Animals; Animals, Newborn; Apoptosis; Astrocytes; Benzeneacetamides; Benzimidazoles; Bisbenzimidazole; Carbocyanines; Cell Line, Tumor; Cell Nucleus; Cell Survival; Cells, Cultured; Dizocilpine Maleate; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Glutamic Acid; Glutathione; Hydrogen Peroxide; Ion Channels; Microscopy, Fluorescence; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Morphine; Naloxone; Narcotic Antagonists; Neuroglia; Oxidation-Reduction; Oxidative Stress; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Rhodamine 123	2004
Activation of mu opioid receptors in the ventrolateral periaqueductal gray inhibits reflex micturition in anesthetized rats. Neuroscience letters, 2004, Jun-10, Volume: 363, Issue:2 Topics: Administration, Intravesical; Anesthetics; Animals; Benzeneacetamides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Female; Microinjections; Morphine; Muscle Contraction; Narcotics; Periaqueductal Gray; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex; Sodium Chloride; Urinary Bladder; Urination	2004
Opioid receptors in fast and slow skeletal muscles of normal and dystrophic mice. Neuroscience letters, 2004, Aug-19, Volume: 366, Issue:3 Topics: Analysis of Variance; Animals; Autoradiography; Benzeneacetamides; beta-Endorphin; Binding Sites; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Iodine Isotopes; Mice; Mice, Inbred C57BL; Muscle Fibers, Fast-Twitch; Muscle Fibers, Slow-Twitch; Muscle, Skeletal; Muscular Dystrophy, Animal; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu	2004
Increased opioid receptor binding and G protein coupling in the accumbens and ventral tegmental area of postnatal day 2 rats. Neuroscience letters, 2006, Mar-13, Volume: 395, Issue:3 Topics: Animals; Animals, Newborn; Autoradiography; Benzeneacetamides; Enkephalin, D-Penicillamine (2,5)-; Female; Guanosine 5'-O-(3-Thiotriphosphate); Nociceptin; Nociceptin Receptor; Nucleus Accumbens; Opioid Peptides; Pregnancy; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Opioid; Receptors, Opioid, mu; Ventral Tegmental Area	2006
N-substituted cis-4a-(3-hydroxyphenyl)-8a-methyloctahydroisoquinolines are opioid receptor pure antagonists. Journal of medicinal chemistry, 2005, Dec-29, Volume: 48, Issue:26 Topics: Animals; Benzeneacetamides; CHO Cells; Cricetinae; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Isoquinolines; Models, Molecular; Molecular Conformation; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu	2005
Opioid regulation of spinal cord plasticity: evidence the kappa-2 opioid receptor agonist GR89696 inhibits learning within the rat spinal cord. Neurobiology of learning and memory, 2008, Volume: 89, Issue:1 Topics: Adaptation, Physiological; Animals; Association Learning; Benzeneacetamides; Conditioning, Operant; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Male; Neuronal Plasticity; Neurons; Neurotransmitter Agents; Piperazines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Spinal Cord; Spinal Cord Injuries; Thoracic Vertebrae	2008
Displacement of opioid receptor binding ligands from the rat brain by N3-(2',5'-dimethoxyphenacyl) arabinofuranosyluracil. Research communications in molecular pathology and pharmacology, 2005, Volume: 117-118 Topics: Analgesics, Opioid; Animals; Arabinofuranosyluracil; Autoradiography; Benzeneacetamides; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Injections, Intraventricular; Ligands; Male; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu	2005
Activation of micro, delta or kappa opioid receptors by DAMGO, DPDPE, U-50488 or U-69593 respectively causes antinociception in the formalin test in the naked mole-rat (Heterocephalus glaber). Pharmacology, biochemistry, and behavior, 2009, Volume: 91, Issue:4 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Benzeneacetamides; Data Interpretation, Statistical; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Formaldehyde; Injections, Intraperitoneal; Male; Mole Rats; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Pyrrolidines; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu	2009
Effects of opioid receptor activation on thermal antinociception in red-eared slider turtles (Trachemys scripta). American journal of veterinary research, 2009, Volume: 70, Issue:9 Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Cross-Over Studies; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Female; Hot Temperature; Male; Nociceptors; Pyrrolidines; Receptors, Opioid, mu; Sodium Chloride; Turtles	2009
Kappa2 opioid receptor subtype binding requires the presence of the DOR-1 gene. Frontiers in bioscience (Scholar edition), 2010, 01-01, Volume: 2, Issue:2 Topics: Analysis of Variance; Animals; Benzeneacetamides; Diprenorphine; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Mice; Mice, Knockout; Pain Measurement; Protein Binding; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Regression Analysis	2010
Standard opioid agonists activate heteromeric opioid receptors: evidence for morphine and [d-Ala(2)-MePhe(4)-Glyol(5)]enkephalin as selective μ-δ agonists. ACS chemical neuroscience, 2010, Feb-17, Volume: 1, Issue:2 Topics: Analgesics, Opioid; Area Under Curve; Benzeneacetamides; Calcium Signaling; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Guanosine 5'-O-(3-Thiotriphosphate); HEK293 Cells; Humans; Immunohistochemistry; Ligands; Morphine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu	2010
In vivo profiling of seven common opioids for antinociception, constipation and respiratory depression: no two opioids have the same profile. British journal of pharmacology, 2015, Volume: 172, Issue:2 Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Buprenorphine; Castor Oil; Constipation; Diarrhea; Enkephalin, D-Penicillamine (2,5)-; Fentanyl; Hot Temperature; Male; Morphine; Morphine Derivatives; Oxycodone; Pain; Pyrrolidines; Rats, Sprague-Dawley; Respiratory Insufficiency	2015
Differential effects of exercise on brain opioid receptor binding and activation in rats. Journal of neurochemistry, 2015, Volume: 132, Issue:2 Topics: Amygdala; Animals; Benzeneacetamides; Brain Chemistry; Cerebral Cortex; Electroshock; Enkephalin, D-Penicillamine (2,5)-; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Hypothalamus; Naloxone; Nerve Tissue Proteins; Opioid Peptides; Physical Conditioning, Animal; Protein Binding; Pyrrolidines; Rats; Receptors, Opioid; Signal Transduction; Time Factors	2015