u 69593 has been researched along with enkephalin, ala(2)-mephe(4)-gly(5)- in 152 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (3.95) | 18.7374 |
| 1990's | 82 (53.95) | 18.2507 |
| 2000's | 45 (29.61) | 29.6817 |
| 2010's | 17 (11.18) | 24.3611 |
| 2020's | 2 (1.32) | 2.80 |
| Authors | Studies |
|---|---|
| Akil, H; Goldstein, A; Mansour, A; Meng, F; Thompson, RC; Watson, SJ; Xie, GX | 1 |
| Adapa, ID; Auh, JS; Berzetei-Gurske, IP; Brandt, SR; Craymer, K; Farrington, L; Haggart, D; Kennedy, JM; O'Brien, A; Polgar, WE; Rodriguez, L; Schwartz, RW; Toll, L; White, A | 1 |
| Horikawa, M; Nakajima, T; Ohfune, Y; Shigeri, Y; Yoshikawa, S; Yumoto, N | 1 |
| Burgess, JP; Carroll, FI; Dersch, CM; Herault, XM; Horel, RB; Mascarella, SW; Rothman, RB; Thomas, JB; Xu, H | 1 |
| Atkinson, RN; Carroll, FI; Dersch, CM; Herault, XM; Horel, RB; Mascarella, SW; Rothman, RB; Thomas, JB; Xu, H | 1 |
| Atkinson, RN; Burgess, JP; Carroll, FI; Dersch, CM; Flippen-Anderson, JL; George, CF; Herault, XM; Mascarella, SW; Rothman, RB; Thomas, JB; Xu, H | 1 |
| Grundt, P; Husbands, SM; Jales, AR; Lewis, JW; Traynor, JR | 1 |
| Ananthan, S; Bartlett, JL; Bilsky, EJ; Davis, P; Dersch, CM; Khare, NK; Porreca, F; Rothman, RB; Saini, SK; Seitz, LE | 1 |
| Al-Ghananeem, AM; Butterfield, DA; Byrn, SR; Crooks, PA; Kottayil, SG | 1 |
| Aoki, T; Endo, T; Fujii, H; Hasebe, K; Ito, T; Kamei, J; Kawai, K; Kawamura, K; Maeda, M; Nagase, H; Nakajima, M; Sakami, S; Ueno, S | 1 |
| Arumugan, T; Carroll, AR; Forster, PI; Guymer, GP; Ngo, A; Quinn, RJ; Redburn, J | 1 |
| Cami-Kobeci, G; Husbands, SM; Khroyan, TV; Polgar, WE; Toll, L | 1 |
| Dersch, CM; Deschamps, JR; Iyer, MR; Jacobson, AE; Lee, YS; Rice, KC; Rothman, RB | 1 |
| Dersch, CM; Iyer, MR; Jacobson, AE; Rice, KC; Rothman, RB | 2 |
| Dersch, CM; Deschamps, JR; Jacobson, AE; Lim, HJ; Rice, KC; Rothman, RB | 1 |
| Ambo, A; Cai, J; Cai, Y; Lam, AL; Lazarus, LH; Li, T; Ma, Y; Magiera, J; Sasaki, Y; Sekar, S; Smith, MT; Song, B; Wyse, BD | 1 |
| Journigan, VB; Khroyan, TV; Polgar, WE; Zaveri, NT | 1 |
| Benyhe, S; Borsodi, A; Carotenuto, A; Costante, R; Davis, P; Hruby, VJ; Limatola, A; Mollica, A; Novellino, E; Pieretti, S; Pinnen, F; Porreca, F; Samavati, R; Stefanucci, A; Zador, F | 1 |
| Fujii, H; Hirayama, S; Hirono, S; Iwai, T; Kuroda, N; Nagase, H; Wada, N; Yamaotsu, N | 1 |
| Bezawada, P; Coop, A; Cunningham, CW; Devereaux, AL; Griggs, NW; Healy, JR; Matsumoto, RR; Traynor, JR | 1 |
| Chadderdon, AM; Deschamps, JR; Hassan, SA; Jacobson, AE; Katz, JL; Kopajtic, TA; Lee, YS; Rice, KC; Traynor, JR; Truong, PM | 1 |
| Avery, BA; Behnke, M; Chear, NJ; Hiranita, T; Kamble, SH; León, F; McCurdy, CR; McMahon, LR; Obeng, S; Patel, A; Ramanathan, S; Reeves, ME; Restrepo, LF; Sharma, A | 1 |
| Fujii, H; Gouda, H; Higashi, E; Hirayama, S; Nagase, H; Tsumura, S; Uenohara, Y; Watanabe, Y | 1 |
| Gu, ZF; Jensen, RT; Maton, PN; Pradhan, T; Zhang, L | 1 |
| Borsodi, A; Búzás, B; Cavagnero, S; Hruby, VJ; Tóth, G | 1 |
| Barnard, EA; Richardson, A; Simon, J | 1 |
| Green, IC; Khawaja, XZ | 1 |
| Kuemmerle, JF; Makhlouf, GM | 1 |
| Barnard, EA; Demoliou-Mason, C; Richardson, A | 1 |
| Besse, D; Besson, JM; Lombard, MC; Perrot, S | 1 |
| Finberg, RW; Heagy, W; Shipp, MA | 1 |
| Besse, D; Besson, JM; Butler, SH; Lombard, MC; Weil-Fugazza, J | 1 |
| Dziedzicka, M; Lasoń, W; Przewłocka, B; Przewłocki, R | 1 |
| Herz, A; Shippenberg, TS; Spanagel, R | 1 |
| Cometta-Morini, C; Kamal, J; Loew, G; Maguire, P; Tsai, N; Upton, C | 1 |
| Leslie, FM; Loughlin, SE; Smith, JA | 1 |
| Christensen, CB; Reiff, L | 1 |
| Dissanayake, VU; Hughes, J; Hunter, JC | 1 |
| Hauser, KF; Stiene-Martin, A | 1 |
| Imanishi, Y; Kimura, S; Sasaki-Yagi, Y | 1 |
| Enger, M; Grynne, BH; Holmen, AT; Maurset, AR | 1 |
| Cheng, J; Pasternak, GW; Paul, D; Pick, CG | 1 |
| Kromer, W | 1 |
| Adler, MW; Eisenstein, TK; Geller, EB; Rogers, TJ; Taub, DD | 1 |
| Bettaney, J; Dray, A; James, IF; Ketchum, SB; Perkins, MN | 1 |
| Magnan, J; Tiberi, M | 2 |
| Dissanayake, VU; Hill, RG; Hughes, J; Hunter, JC | 1 |
| Bourne, RC; Csillag, A; Stewart, MG | 1 |
| Dashwood, MR; Mathias, CJ; May, CN; Whitehead, CJ | 1 |
| Bastagli, L; Bernardi, P; Caldarera, CM; Guarnieri, C; Ventura, C | 1 |
| La Regina, A; Petrillo, P; Sbacchi, M; Tavani, A | 1 |
| Cicero, TJ; Nock, B; O'Connor, LH; Rajpara, A | 1 |
| De Montis, GM; Devoto, P; Preti, A; Tagliamonte, A | 1 |
| Garzón, J; Sánchez-Blázquez, P | 1 |
| Fukuda, K; Fukushima, N; Misu, Y; Miyamae, T; Sasaki, Y; Takeshima, H; Ueda, H | 1 |
| Archer, S; Bidlack, JM; Jiang, Q; Seyed-Mozaffari, A | 1 |
| Kuraishi, Y; Oyama, T; Satoh, M; Sugimoto, K; Ueda, M | 1 |
| Kuznetsov, A; Ma, GH; Miller, RJ; Philipson, LH | 1 |
| Glick, SD; Herrick-Davis, K; Pearl, SM; Teitler, M | 1 |
| Almeida, OF; Shippenberg, TS; Spanagel, R | 1 |
| Mignat, C; Wille, U; Ziegler, A | 1 |
| Búzás, B; Cox, BM; Izenwasser, S | 1 |
| Iwai, T; Luay, AE; Niwa, M; Nozaki, M; Tsurumi, K | 1 |
| Barg, J; Belcheva, MM; Coscia, CJ; Dawn, S; Ho, MT; Ignatova, E; McHale, RJ | 1 |
| Bernstein, RN; Bilsky, EJ; Hruby, VJ; Lai, J; Pasternak, GW; Patel, D; Porreca, F | 1 |
| Glaum, SR; Miller, RJ; Rhim, H | 1 |
| Barg, J; Belcheva, M; Burke, WJ; Chung, HD; Coscia, CJ; Ho, A; Rowinski, J; Schmidt, CA | 1 |
| Fukushima, N; Misu, Y; Miyamae, T; Ueda, H | 1 |
| Mulder, AH; Ronken, E; Schoffelmeer, AN | 1 |
| Beatty, MF; Casy, AF; Kamal, JJ; Loew, GH; Maguire, PA; Perez, JJ; Rodriguez, L; Tsai, NF; Upton, C; Villar, HO | 1 |
| Ishige, K; Ito, Y; Makimura, M; Murakoshi, Y | 1 |
| Desmeules, JA; Guilbaud, G; Kayser, V | 1 |
| Davis, P; DeLeon, IA; Hruby, VJ; Li, G; Lou, BS; Lung, FD; Meyer, JP; Porreca, F; Xiang, L; Yamamura, HI | 1 |
| Avidor-Reiss, T; Levy, R; Nevo, I; Pfeuffer, T; Vogel, Z | 1 |
| Cox, BM; Stevens, BA; Tang, T | 1 |
| Chang, KJ; Li, LY | 1 |
| Allard, M; Jordan, D; Kopp, N; Martin, D; Ries, C; Simonnet, G; Tafani, JA; Zajac, JM | 1 |
| Demedts, MG; Dupont, LJ; Pype, JL; Verleden, GM | 1 |
| Obermeier, H; Schulz, R; Wehmeyer, A | 1 |
| Nelson, WL; Palmer, RB; Upthagrove, AL | 1 |
| Archer, S; Bidlack, JM; McLaughlin, JP; Sebastian, A | 1 |
| Berzetei-Gurske, IP; Chang, AC; Portoghese, PS; Schwartz, RW | 1 |
| Caudle, RM; Dubner, R; Ho, J; Mannes, AJ | 1 |
| Contarino, A; Drago, F; Giusti, P; Lipartiti, M; Natolino, F; Zanotti, A | 1 |
| Bandler, R; Christie, MJ; Crowfoot, LJ; Floyd, NS; Henderson, LA; Keay, KA | 1 |
| Eckhoff, B; Frenzen, G; Höfner, G; Klindert, T; Seitz, G; Stroetmann, I; Wanner, KT | 1 |
| Hogenboom, F; Mulder, AH; Schoffelmeer, AN | 1 |
| Gauthier, CA; Gonzales, GR; Minor, LD; Paul, D | 1 |
| Bhargava, HN; Cortijo, J; Morcillo, EJ; Villar, VM | 1 |
| Avidor-Reiss, T; Barg, J; Belcheva, MM; Coscia, CJ; Ignatova, E; Levy, R; Vogel, Z; Young, EC; Zippel, R | 1 |
| Bizot-Espiard, JG; Caignard, DH; Guillaumet, G; Pfeiffer, B; Renard, P; Savelon, L; Viaud, MC | 1 |
| Aynsley-Green, A; Dashwood, MR; Dickenson, AH; Fitzgerald, M; Rahman, W | 1 |
| Borsodi, A; Hosztafi, S; Nevin, ST; Rónai, AZ; Spetea, M; Tóth, G | 1 |
| Lysle, DT; Schneider, GM | 1 |
| Cheng, ZJ; Ma, L; Pei, G; Wu, YL; Yu, QM | 1 |
| Foxx-Orenstein, AE; Grider, JR; Jin, JG | 1 |
| Abdulla, FA; Smith, PA | 1 |
| Dersch, C; Kubota, H; McCullough, K; Pinto, J; Rice, KC; Rothman, RB | 1 |
| Higashi, H; Kohno, T; Kumamoto, E; Shimoji, K; Yoshimura, M | 1 |
| Heyliger, SO; Lai, J; Ni, Q; Partilla, JS; Rice, KC; Romero, DV; Rothman, RB; Zheng, QX | 1 |
| Madamba, SG; Schweitzer, P; Siggins, GR | 1 |
| Heyliger, SO; Jackson, C; Rice, KC; Rothman, RB | 1 |
| Bigoni, R; Borea, PA; Calo, G; Gessi, S; Guerrini, R; Regoli, D; Rizzi, A; Salvadori, S; Toth, G; Varani, K | 1 |
| Andria, ML; Hiller, JM; Onoprishvili, I; Simon, EJ; Vilim, FS | 1 |
| Corbett, AD; Davies, MR; Glen, T; Menzies, JR; Paterson, SJ | 1 |
| Bidlack, JM; Cioffi, CL; Cohen, DJ; Colasurdo, AM; Duan, W; Wentland, MP; Xu, G; Ye, Y | 1 |
| Inoue, M; Ueda, H | 1 |
| Ho, IK; Jang, C; Ko, KH; Loh, HH; Ma, T; Park, Y; Tanaka, S | 1 |
| Cheong, YP; Cho, KP; Kim, CJ; Kim, JK; Kim, KW; Kwun, J; Woo, RS | 1 |
| Belcheva, MM; Coscia, CJ; Wong, YH | 1 |
| Balboni, G; Bryant, SD; Butterworth, J; Guerrini, R; Labarre, M; Lazarus, LH; Payza, K; Salvadori, S; Schmidhammer, H; St-Onge, S | 1 |
| Husbands, SM; Jales, AR; Lewis, JW | 1 |
| Eckert, WA; Light, AR; Willcockson, HH | 1 |
| Allen, CN; Grandy, DK; Ikeda, M; Nelson, CS; Shinagawa, H; Shinoe, T; Sugiyama, T; Yoshioka, T | 1 |
| Dermitzaki, E; Gravanis, A; Margioris, AN; Stournaras, C; Venihaki, M | 1 |
| Ananthan, S; Lu, YF; Rice, KC; Rothman, RB; Xu, H | 1 |
| Schoffelmeer, AN; Vanderschuren, LJ; Wardeh, G | 1 |
| Brown, DR; Townsend, D | 1 |
| Gear, RW; Levine, JD; Schmidt, BL; Tambeli, CH | 1 |
| Newman, LC; Sands, SS; Stevens, CW; Wallace, DR | 1 |
| Canciani, L; Frigo, G; Giaroni, C; Lecchini, S; Vanti, A; Zanetti, E | 1 |
| Martin-Kleiner, I | 1 |
| Irvine, RJ; Lewanowitsch, T | 1 |
| Bagley, EE; Christie, MJ; Drew, GM; Hack, SP; Pintar, JE; Schuller, A; Vaughan, CW | 1 |
| Choi, SS; Kim, KW; Suh, HW; Woo, RS | 1 |
| Bie, B; Pan, ZZ | 1 |
| Bishop, MJ; Chang, KJ; Gengo, PJ; McNutt, R; O'Neill, SJ; Pettit, HO; Wei, K | 1 |
| Bonci, A; Fields, HL; Hjelmstad, GO; Margolis, EB | 2 |
| Choi, DH; Jung, EB; Kim, MS; Kim, TY; Lee, J; Moon, SK; Park, C; Park, R | 1 |
| Levendusky, MC; Levin, RM; Longhurst, PA; Matsumoto, S; Millington, WR | 1 |
| Evans, AA; Smith, ME | 1 |
| Christie, MJ; Connor, M; Marinelli, S; Schnell, SA; Vaughan, CW; Wessendorf, MW | 1 |
| Belcheva, MM; Clark, AL; Coscia, CJ; Haas, PD; Hahn, JW; Kiss, A; Serna, JS | 1 |
| Bart, G; Bidlack, JM; Borg, L; Ho, A; Kreek, MJ; Schluger, JH | 1 |
| Carroll, FI; Chaudhari, S; Deschamps, J; Gigstad, KM; Mascarella, SW; Navarro, HA; Thomas, JB | 1 |
| Canciani, L; Crema, F; Frigo, G; Giaroni, C; Giuliani, D; Lecchini, S; Moro, E; Pisani, R; Trinchera, M; Zanetti, E | 1 |
| Beattie, DT; Cheruvu, M; Johnson-Rabidoux, S; Kaufman, E; Mai, N; O'Keefe, M; Peterson, C; Vickery, R | 1 |
| He, L; Hjelmstad, GO; Whistler, JL; Xia, YF | 1 |
| Grau, JW; Maultsby, ML; Puga, DA; Washburn, SN | 1 |
| Kohno, T | 1 |
| Funahashi, T; Ho, IK; Kimura, T; Shimizu, T; Watanabe, K; Yamamoto, I | 1 |
| Juma, F; Kanui, TI; Maloiy, GM; Olongida Ole Miaron, J; Towett, PK | 1 |
| DeLeo, JA; Horvath, RJ | 1 |
| Johnson, SM; Kinney, ME; Sladky, KK | 1 |
| Belcheva, MM; Coscia, CJ; Ezerskiy, LA; Hahn, JW; He, J; Jagwani, S; Kim, E; Rendell, VR; Wesselschmidt, R | 1 |
| Hentges, ST; Pennock, RL | 1 |
| Kalyuzhny, AE; Portoghese, PS; Yekkirala, AS | 1 |
| Chang, XM; Fang, Q; Han, ZL; Li, N; Li, XH; Pan, JX; Tang, HH; Wang, P; Wang, R; Wang, ZL; Zheng, T | 1 |
| Abraham, AD; Burgeno, LM; Chavkin, C; Kuhar, JR; Land, BB; Ong, SE; Phillips, PEM; Reichard, KL; Schattauer, SS | 1 |
1 review(s) available for u 69593 and enkephalin, ala(2)-mephe(4)-gly(5)-
| Article | Year |
|---|---|
[Opioids and spinal analgesia].
Topics: Analgesia, Epidural; Analgesics, Opioid; Animals; Benzeneacetamides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Humans; Nerve Fibers; Pain; Posterior Horn Cells; Pyrrolidines; Receptors, Opioid; Synapses; Synaptic Transmission | 2007 |
151 other study(ies) available for u 69593 and enkephalin, ala(2)-mephe(4)-gly(5)-
| Article | Year |
|---|---|
Cloning and pharmacological characterization of a rat kappa opioid receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Analgesics; Animals; Benzeneacetamides; Cell Line; Cell Membrane; Cloning, Molecular; Corpus Striatum; Cyclic AMP; DNA Primers; DNA, Complementary; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gene Library; In Situ Hybridization; Inositol 1,4,5-Trisphosphate; Kinetics; Ligands; Molecular Sequence Data; Pyrrolidines; Rats; Receptors, Opioid, kappa; Restriction Mapping; RNA, Messenger; Transfection | 1993 |
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.
Topics: Animals; Aorta, Thoracic; Cocaine; Cyclic AMP; Electric Stimulation; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Opioid-Related Disorders; Rats; Receptors, Dopamine; Receptors, Opioid; Receptors, Serotonin; Substance-Related Disorders | 1998 |
Syntheses of potent Leu-enkephalin analogs possessing beta-hydroxy-alpha,alpha-disubstituted-alpha-amino acid and their characterization to opioid receptors.
Topics: Amino Acids; Animals; CHO Cells; Cricetinae; Cyclic AMP; Enkephalin, Leucine; Rats; Receptors, Opioid | 1998 |
(+/-)-4-[(N-allyl-cis-3-methyl-4-piperidinyl)phenylamino]-N,N-diethylbenzamide displays selective binding for the delta opioid receptor.
Topics: Benzamides; Piperazines; Piperidines; Radioligand Assay; Receptors, Opioid, delta | 1999 |
Optically pure (-)-4-[(N-allyl-3-methyl-4-piperidinyl)phenyl-amino]-N,N-diethylbenzami de displays selective binding and full agonist activity for the delta opioid receptor.
Topics: Benzamides; Brain; Piperidines; Radioligand Assay; Receptors, Opioid, delta | 1999 |
Factors influencing agonist potency and selectivity for the opioid delta receptor are revealed in structure-activity relationship studies of the 4-[(N-substituted-4-piperidinyl)arylamino]-N,N-diethylbenzamides.
Topics: Animals; Benzamides; Brain; Crystallography, X-Ray; Guinea Pigs; In Vitro Techniques; Ligands; Piperazines; Piperidines; Radioligand Assay; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stereoisomerism; Structure-Activity Relationship | 2001 |
14-amino, 14-alkylamino, and 14-acylamino analogs of oxymorphindole. Differential effects on opioid receptor binding and functional profiles.
Topics: Analgesics, Opioid; Animals; Binding, Competitive; CHO Cells; Cricetinae; Morpholines; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship | 2003 |
Identification of opioid ligands possessing mixed micro agonist/delta antagonist activity among pyridomorphinans derived from naloxone, oxymorphone, and hydromorphone [correction of hydropmorphone].
Topics: Analgesics; Animals; Binding Sites; Brain; Drug Tolerance; Electric Stimulation; Guinea Pigs; Hydromorphone; Ileum; In Vitro Techniques; Ligands; Male; Mice; Mice, Inbred ICR; Morphinans; Muscle Contraction; Muscle, Smooth; Naloxone; Oxymorphone; Pyridines; Radioligand Assay; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Vas Deferens | 2004 |
Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners.
Topics: Animals; Codeine; Dihydromorphine; Esters; Guinea Pigs; Inhibitory Concentration 50; Kinetics; Ligands; Models, Chemical; Morphine; Protein Binding; Sulfates | 2006 |
Structure-antitussive activity relationships of naltrindole derivatives. Identification of novel and potent antitussive agents.
Topics: Alkylation; Animals; Antitussive Agents; Capsaicin; CHO Cells; Cough; Cricetinae; Cricetulus; Male; Mice; Molecular Structure; Naltrexone; Rats; Structure-Activity Relationship | 2008 |
Hasubanan alkaloids with delta-opioid binding affinity from the aerial parts of Stephania japonica.
Topics: Alkaloids; Australia; Humans; Inhibitory Concentration 50; Molecular Structure; Plants, Medicinal; Receptors, Opioid, delta; Receptors, Opioid, kappa; Stephania | 2010 |
Structural determinants of opioid and NOP receptor activity in derivatives of buprenorphine.
Topics: Animals; Buprenorphine; CHO Cells; Cricetinae; Cricetulus; Drug Partial Agonism; Humans; Ligands; Models, Molecular; Nociceptin Receptor; Radioligand Assay; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stereoisomerism; Structure-Activity Relationship | 2011 |
Probes for narcotic receptor mediated phenomena. 44. Synthesis of an N-substituted 4-hydroxy-5-(3-hydroxyphenyl)morphan with high affinity and selective μ-antagonist activity.
Topics: Animals; Azabicyclo Compounds; CHO Cells; Cricetinae; Cricetulus; Crystallography, X-Ray; Guanosine 5'-O-(3-Thiotriphosphate); Molecular Structure; Morphinans; Narcotic Antagonists; Protein Binding; Receptors, Opioid; Receptors, Opioid, mu; Stereoisomerism; Structure-Activity Relationship | 2012 |
Probes for narcotic receptor mediated phenomena. 47. Novel C4a- and N-substituted-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-6-ols.
Topics: Animals; Cell Membrane; CHO Cells; Cricetulus; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Molecular Structure; Narcotic Antagonists; Pyridines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship; Sulfur Radioisotopes; Tritium | 2013 |
Probes for narcotic receptor mediated phenomena. 48. C7- and C8-substituted 5-phenylmorphan opioids from diastereoselective alkylation.
Topics: Alkylation; Animals; Cells, Cultured; CHO Cells; Cricetulus; Crystallography, X-Ray; Dose-Response Relationship, Drug; Humans; Models, Molecular; Molecular Conformation; Morphinans; Receptors, Opioid; Stereoisomerism; Structure-Activity Relationship | 2013 |
Endomorphin analogues with mixed μ-opioid (MOP) receptor agonism/δ-opioid (DOP) receptor antagonism and lacking β-arrestin2 recruitment activity.
Topics: Animals; Arrestins; beta-Arrestins; Colforsin; Cyclic AMP; Guinea Pigs; HEK293 Cells; Humans; Male; Mice; Molecular Structure; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 2014 |
Designing bifunctional NOP receptor-mu opioid receptor ligands from NOP-receptor selective scaffolds. Part II.
Topics: Analgesics; Animals; Ligands; Mice; Models, Animal; Nociceptin Receptor; Pain; Piperidines; Protein Binding; Receptors, Opioid; Receptors, Opioid, mu; Structure-Activity Relationship | 2014 |
Novel cyclic biphalin analogue with improved antinociceptive properties.
Topics: | 2014 |
Synthesis of a novel universal opioid receptor agonist with the 1,3,5-trioxazatriquinane skeleton and its pharmacologies.
Topics: Animals; Dose-Response Relationship, Drug; Guinea Pigs; Heterocyclic Compounds, 4 or More Rings; Humans; Mice; Molecular Conformation; Receptors, Opioid, kappa; Structure-Activity Relationship | 2014 |
Probes for narcotic receptor mediated phenomena 49. N-substituted rac-cis-4a-arylalkyl-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-6-ols.
Topics: Benzofurans; Dose-Response Relationship, Drug; Heterocyclic Compounds, 3-Ring; Humans; Molecular Structure; Piperidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship | 2015 |
Benzylideneoxymorphone: A new lead for development of bifunctional mu/delta opioid receptor ligands.
Topics: Analgesics; Animals; Benzylidene Compounds; Ligands; Mice; Oxymorphone; Pain; Receptors, Opioid, delta; Receptors, Opioid, mu | 2017 |
Modulation of opioid receptor affinity and efficacy via N-substitution of 9β-hydroxy-5-(3-hydroxyphenyl)morphan: Synthesis and computer simulation study.
Topics: Carbon-13 Magnetic Resonance Spectroscopy; Computer Simulation; Crystallography, X-Ray; Models, Molecular; Molecular Dynamics Simulation; Morphinans; Protein Binding; Proton Magnetic Resonance Spectroscopy; Receptors, Opioid; Spectrometry, Mass, Electrospray Ionization | 2017 |
Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids.
Topics: Adrenergic Agents; Analgesics; Animals; Blood Proteins; CHO Cells; Cricetulus; Dopamine Agents; Guinea Pigs; Humans; Microsomes, Liver; Rats; Receptors, Adrenergic; Receptors, Opioid; Secologanin Tryptamine Alkaloids | 2020 |
Morphinan derivatives with an oxabicyclo[3.2.1]octane structure as dual agonists toward δ and κ opioid receptors.
Topics: Analgesics; Dose-Response Relationship, Drug; Humans; Molecular Structure; Morphinans; Receptors, Opioid, delta; Receptors, Opioid, kappa; Structure-Activity Relationship | 2022 |
Characterization of opioid receptors on smooth muscle cells from guinea pig stomach.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gastric Mucosa; Guinea Pigs; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Naloxone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Stomach | 1992 |
Synthesis and binding characteristics of the highly delta-specific new tritiated opioid peptide, [3H]deltorphin II.
Topics: Analgesics; Animals; Benzeneacetamides; Brain; Cell Membrane; Dihydromorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Indicators and Reagents; Isotope Labeling; Kinetics; Oligopeptides; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium | 1992 |
Protection by opioid ligands against modification of the opioid receptor by a carbodiimide.
Topics: Animals; Benzeneacetamides; Benzomorphans; Binding Sites; Brain Chemistry; Carbodiimides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guanylyl Imidodiphosphate; Guinea Pigs; Pyrrolidines; Receptors, Opioid | 1992 |
Studies on the effects of glucose in vitro and of the glycaemic state in vivo on the binding characteristics of mu, delta and kappa opiate receptors in mouse brain.
Topics: Animals; Benzeneacetamides; Binding, Competitive; Brain; Diabetes Mellitus, Experimental; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glucose; Ligands; Mice; Mice, Inbred C57BL; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Streptozocin | 1992 |
Characterization of opioid receptors in intestinal muscle cells by selective radioligands and receptor protection.
Topics: Animals; Benzeneacetamides; Cells, Cultured; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Intestinal Mucosa; Ligands; Muscle, Smooth; Osmolar Concentration; Pyrrolidines; Radioligand Assay; Receptors, Opioid; Temperature; Time Factors | 1992 |
Guanine nucleotide-binding protein-coupled and -uncoupled states of opioid receptors and their relevance to the determination of subtypes.
Topics: Analgesics; Animals; Benzeneacetamides; Benzomorphans; Binding, Competitive; Cell Membrane; Cerebellum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Etorphine; Female; GTP-Binding Proteins; Guinea Pigs; Humans; Kinetics; Ligands; Placenta; Pregnancy; Prosencephalon; Protein Binding; Pyrrolidines; Rats; Receptors, Opioid | 1992 |
Regulation of opioid binding sites in the superficial dorsal horn of the rat spinal cord following loose ligation of the sciatic nerve: comparison with sciatic nerve section and lumbar dorsal rhizotomy.
Topics: Analgesics; Animals; Autoradiography; Benzeneacetamides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Nerve Degeneration; Neurons, Afferent; Oligopeptides; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sciatic Nerve; Spinal Cord | 1992 |
Opioid receptor agonists and Ca2+ modulation in human B cell lines.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; B-Lymphocytes; Benzeneacetamides; Calcium; Cell Line; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Flow Cytometry; Humans; Naloxone; Pyrrolidines; Receptors, Opioid; Signal Transduction | 1992 |
Monoarthritis induces complex changes in mu-, delta- and kappa-opioid binding sites in the superficial dorsal horn of the rat spinal cord.
Topics: Animals; Arthritis; Arthritis, Experimental; Autoradiography; Benzeneacetamides; Disease Models, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Freund's Adjuvant; Male; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1992 |
Differential effects of opioid receptor agonists on nociception and cAMP level in the spinal cord of monoarthritic rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Arthritis; Benzeneacetamides; Colforsin; Cyclic AMP; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guanylyl Imidodiphosphate; Injections, Spinal; Male; Morphine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord | 1992 |
Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway.
Topics: Analgesics; Animals; Benzeneacetamides; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Infusions, Parenteral; Limbic System; Male; Microinjections; Models, Neurological; Naltrexone; Nucleus Accumbens; Pyrrolidines; Rats; Rats, Inbred Strains; Somatostatin; Tegmentum Mesencephali | 1992 |
Pharmacological profiles of fentanyl analogs at mu, delta and kappa opiate receptors.
Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Guinea Pigs; Ileum; Male; Mice; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens | 1992 |
kappa-Opioid inhibition of [3H]dopamine release from rat ventral mesencephalic dissociated cell cultures.
Topics: Animals; Benzeneacetamides; Calcium; Cells, Cultured; Dopamine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Mesencephalon; Narcotics; Potassium; Pyrrolidines; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tetrodotoxin | 1992 |
Morphine-6-glucuronide: receptor binding profile in bovine caudate nucleus.
Topics: Analgesics; Animals; Benzeneacetamides; Cattle; Caudate Nucleus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Kinetics; Morphine; Morphine Derivatives; Pyrrolidines; Receptors, Opioid | 1991 |
Opioid binding sites in the guinea pig and rat kidney: radioligand homogenate binding and autoradiography.
Topics: Analgesics; Animals; Autoradiography; Benzeneacetamides; Binding, Competitive; Cations; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Guinea Pigs; Kidney; Kinetics; Narcotic Antagonists; Nucleotides; Pyrrolidines; Radioligand Assay; Rats; Receptors, Opioid; Receptors, Opioid, delta; Tritium | 1991 |
Glial growth is regulated by agonists selective for multiple opioid receptor types in vitro.
Topics: Analgesics; Animals; Animals, Newborn; Astrocytes; Benzeneacetamides; Cells, Cultured; DNA Replication; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Glial Fibrillary Acidic Protein; Immunohistochemistry; Mice; Mice, Inbred ICR; Neuroglia; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thymidine | 1991 |
Binding to opioid receptors of enkephalin derivatives taking alpha-helical conformation and its dimer.
Topics: Amino Acid Sequence; Animals; Benzeneacetamides; Brain Chemistry; Cattle; Cell Membrane; Cells, Cultured; Circular Dichroism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Kinetics; Ligands; Lipid Bilayers; Molecular Sequence Data; Pyrrolidines; Receptors, Opioid | 1991 |
Effect of opioid agonists selective for three subclasses of opioid receptors and one sigma receptor agonist on dopamine stimulated adenylate cyclase in rat caudate nucleus.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Animals; Benzeneacetamides; Caudate Nucleus; Cyclic AMP; Dopamine; Dopamine Antagonists; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid | 1991 |
Genetic influences in opioid analgesic sensitivity in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; Benzeneacetamides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mice; Mice, Inbred Strains; Morphine; Naloxone; Pain; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Species Specificity | 1991 |
Voltage-clamp experiments reveal receptor type-dependent modulation of chloride secretion in the guinea pig colonic mucosa by intestinal opioids.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alprostadil; Amiloride; Amino Acid Sequence; Analgesics; Animals; Benzeneacetamides; Chlorides; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Gluconates; Guinea Pigs; Intestinal Mucosa; Male; Membrane Potentials; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin; Tetrodotoxin; Theophylline | 1991 |
Immunomodulatory activity of mu- and kappa-selective opioid agonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Antibody Formation; Antibody-Producing Cells; Benzeneacetamides; Cells, Cultured; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Immunosuppression Therapy; Kinetics; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred Strains; Morphine; Naloxone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1991 |
Opioid receptor ligands in the neonatal rat spinal cord: binding and in vitro depression of the nociceptive responses.
Topics: Animals; Animals, Newborn; Benzeneacetamides; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; In Vitro Techniques; Kinetics; Ligands; Morphine; Muscle, Smooth, Vascular; Naloxone; Narcotics; Nociceptors; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Spinal Cord | 1990 |
Demonstration of the heterogeneity of the kappa-opioid receptors in guinea-pig cerebellum using selective and nonselective drugs.
Topics: Animals; Benzeneacetamides; Benzomorphans; Binding, Competitive; Cerebellum; Computers; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; Guinea Pigs; In Vitro Techniques; Kinetics; Male; Membranes; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1990 |
Characterization of kappa-opioid receptors in the guinea-pig ileum.
Topics: Animals; Benzeneacetamides; Benzomorphans; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Kinetics; Muscle Contraction; Muscle, Smooth; Naloxone; Pyrroles; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Thiophenes | 1990 |
Distribution of mu, delta, and kappa opioid receptor binding sites in the brain of the one-day-old domestic chick (Gallus domesticus): an in vitro quantitative autoradiographic study.
Topics: Analgesics; Animals; Autoradiography; Benzeneacetamides; Brain; Chickens; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Organ Specificity; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium | 1990 |
Evidence for the presence of mu- and kappa- but not of delta-opioid sites in the human fetal brain.
Topics: Benzeneacetamides; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Kinetics; Male; Pyrrolidines; Radioligand Assay; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma | 1989 |
Differential cardiovascular and respiratory responses to central administration of selective opioid agonists in conscious rabbits: correlation with receptor distribution.
Topics: Animals; Autoradiography; Behavior, Animal; Benzeneacetamides; Blood Glucose; Brain Chemistry; Catecholamines; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hemodynamics; Injections, Intraventricular; Medulla Oblongata; Naloxone; Narcotic Antagonists; Pyrrolidines; Rabbits; Receptors, Opioid; Respiration | 1989 |
Opioid receptors in rat cardiac sarcolemma: effect of phenylephrine and isoproterenol.
Topics: Analgesics; Animals; Benzeneacetamides; Bromides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hypotonic Solutions; Isoproterenol; Lithium; Lithium Compounds; Myocardium; Phenylephrine; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sarcolemma | 1989 |
Interaction of U-69,593 with mu-, alpha- and kappa-opioid binding sites and its analgesic and intestinal effects in rats.
Topics: Animals; Benzeneacetamides; Benzomorphans; Binding Sites; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Gastrointestinal Motility; In Vitro Techniques; Male; Naloxone; Nociceptors; Pyrrolidines; Rats; Receptors, Opioid | 1988 |
[3H]U-69593 labels a subtype of kappa opiate receptor with characteristics different from that labeled by [3H]ethylketocyclazocine.
Topics: Animals; Benzeneacetamides; Binding, Competitive; Brain; Cell Membrane; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Male; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Sodium Chloride; Temperature; Tritium | 1988 |
Differential effect of mu, delta, and kappa opioid agonists on adenylate cyclase activity.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclases; Analgesics; Animals; Benzeneacetamides; Benzomorphans; Corpus Striatum; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Male; Morphinans; Peptide Fragments; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid | 1987 |
In vivo injection of antibodies directed against the cloned mu opioid receptor blocked supraspinal analgesia induced by mu-agonists in mice.
Topics: Amino Acid Sequence; Analgesia; Animals; Antibodies; Benzeneacetamides; beta-Endorphin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Immunization, Passive; Male; Mice; Molecular Sequence Data; Morphine; Naloxone; Peptide Fragments; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1995 |
Opioid mu- and kappa-receptor mediate phospholipase C activation through Gi1 in Xenopus oocytes.
Topics: Animals; Benzeneacetamides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Activation; Female; GTP-Binding Proteins; Naltrexone; Oocytes; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Type C Phospholipases; Xenopus laevis | 1995 |
14 alpha,14' beta-[Dithiobis[(2-oxo-2,1-ethanediyl)imino]]bis (7,8-dihydromorphinone) and 14 alpha,14' beta-[dithiobis[(2-oxo-2,1- ethanediyl)imino]]bis[7,8-dihydro-N-(cyclopropylmethyl)normorphinone]: chemistry and opioid binding properties.
Topics: Alkylation; Analgesics; Animals; Benzeneacetamides; Cattle; Cell Membrane; Corpus Striatum; Disulfides; Dithiothreitol; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hydromorphone; Kinetics; Molecular Structure; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tosylphenylalanyl Chloromethyl Ketone | 1994 |
Opioidergic inhibition of capsaicin-evoked release of glutamate from rat spinal dorsal horn slices.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzeneacetamides; Capsaicin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glutamate Dehydrogenase; Glutamic Acid; In Vitro Techniques; Male; Morphine; Nerve Endings; Neurons, Afferent; Opioid Peptides; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1995 |
kappa-Opioid receptor activates an inwardly rectifying K+ channel by a G protein-linked mechanism: coexpression in Xenopus oocytes.
Topics: Animals; Benzeneacetamides; Cloning, Molecular; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Gene Expression; GTP-Binding Proteins; In Vitro Techniques; Mice; Naloxone; Naltrexone; Oocytes; Pertussis Toxin; Potassium Channels; Pyrrolidines; Receptors, Opioid, kappa; RNA, Complementary; Virulence Factors, Bordetella; Xenopus | 1995 |
Radioligand-binding study of noribogaine, a likely metabolite of ibogaine.
Topics: Analgesics; Animals; Benzeneacetamides; Cattle; Cerebral Cortex; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ibogaine; In Vitro Techniques; Kinetics; Naloxone; Pyrrolidines; Radioligand Assay; Receptors, Opioid | 1995 |
Evidence that nor-binaltorphimine can function as an antagonist at multiple opioid receptor subtypes.
Topics: Amino Acid Sequence; Analgesics; Animals; Benzeneacetamides; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Injections, Intraventricular; Male; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Pain; Pain Threshold; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Somatostatin | 1994 |
Affinity profiles of morphine, codeine, dihydrocodeine and their glucuronides at opioid receptor subtypes.
Topics: Animals; Benzeneacetamides; Binding, Competitive; Brain; Codeine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glucuronates; Guinea Pigs; Morphine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium | 1995 |
Differential regulation of adenylyl cyclase activity by mu and delta opioids in rat caudate putamen and nucleus accumbens.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Benzeneacetamides; Caudate Nucleus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Male; Molecular Sequence Data; Naloxone; Naltrexone; Nucleus Accumbens; Oligopeptides; Putamen; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Signal Transduction; Somatostatin | 1993 |
Characterization of opioid receptors in the Mongolian gerbil cerebellum.
Topics: Animals; Autoradiography; Benzeneacetamides; Binding Sites; Binding, Competitive; Cerebellum; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gerbillinae; Guanylyl Imidodiphosphate; In Vitro Techniques; Narcotics; Pyrrolidines; Radioligand Assay; Receptors, Opioid; Receptors, Opioid, mu | 1994 |
Transient down-regulation of neonatal rat brain mu-opioid receptors upon in utero exposure to buprenorphine.
Topics: Analgesics; Animals; Animals, Newborn; Benzeneacetamides; Brain Chemistry; Buprenorphine; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Membranes; Pregnancy; Prenatal Exposure Delayed Effects; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1994 |
Selective inhibition of [D-Ala2, Glu4]deltorphin antinociception by supraspinal, but not spinal, administration of an antisense oligodeoxynucleotide to an opioid delta receptor.
Topics: Analgesics; Animals; Base Sequence; Benzeneacetamides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Molecular Sequence Data; Nociceptors; Oligonucleotides, Antisense; Oligopeptides; Pyrrolidines; Receptors, Opioid, delta | 1994 |
Selective opioid agonists modulate afferent transmission in the rat nucleus tractus solitarius.
Topics: Action Potentials; Afferent Pathways; Analgesics; Animals; Benzeneacetamides; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Medulla Oblongata; Potassium Channels; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Synaptic Transmission | 1993 |
Opioid receptor density changes in Alzheimer amygdala and putamen.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amygdala; Analgesics; Autoradiography; Benzeneacetamides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Female; Frontal Lobe; Humans; Kinetics; Male; Putamen; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reference Values; Tritium | 1993 |
Delta opioid receptor mediates phospholipase C activation via Gi in Xenopus oocytes.
Topics: Analgesics; Animals; Benzeneacetamides; Electric Conductivity; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Enzyme Activation; Female; Gene Expression; GTP-Binding Proteins; Membrane Potentials; Mice; Naltrexone; Narcotic Antagonists; Oocytes; Pyrrolidines; Receptors, Opioid, delta; Type C Phospholipases; Xenopus laevis | 1993 |
Interacting presynaptic kappa-opioid and GABAA receptors modulate dopamine release from rat striatal synaptosomes.
Topics: Analysis of Variance; Animals; Benzeneacetamides; Bicuculline; Corpus Striatum; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; gamma-Aminobutyric Acid; Kinetics; Male; Naltrexone; Narcotics; Oligopeptides; Picrotoxin; Potassium; Pyrrolidines; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Opioid, kappa; Synaptosomes | 1993 |
Molecular mechanism of delta-selectivity of indole analogs of nonpeptide opioids.
Topics: Amino Acid Sequence; Animals; Benzeneacetamides; Binding Sites; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; In Vitro Techniques; Indoles; Molecular Sequence Data; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1993 |
Inhibitory effects of NaCl and guanyl-5'yl-imidodiphosphate (GppNHp) on [3H]naloxone binding to kappa-opioid receptors in guinea pig cerebellum.
Topics: Animals; Benzeneacetamides; Binding Sites; Cerebellum; Cerebral Cortex; Corpus Striatum; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylmaleimide; Guanylyl Imidodiphosphate; Guinea Pigs; Male; Naloxone; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Sodium Chloride | 1993 |
Selective opioid receptor agonists modulate mechanical allodynia in an animal model of neuropathic pain.
Topics: Analgesics; Animals; Benzeneacetamides; Benzomorphans; Disease Models, Animal; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain; Pain Measurement; Pain Threshold; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vocalization, Animal | 1993 |
Effects of modifications of residues in position 3 of dynorphin A(1-11)-NH2 on kappa receptor selectivity and potency.
Topics: Amino Acid Sequence; Analgesics; Animals; Benzeneacetamides; Brain; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Ileum; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Peptide Fragments; Protein Binding; Protein Conformation; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship | 1996 |
Chronic opioid treatment induces adenylyl cyclase V superactivation. Involvement of Gbetagamma.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Analgesics; Animals; Benzeneacetamides; Cell Line; Chlorocebus aethiops; DNA, Complementary; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enzyme Activation; GTP-Binding Proteins; Morphine; Pertussis Toxin; Pyrrolidines; Receptors, Opioid, mu; Transfection; Virulence Factors, Bordetella | 1996 |
Opioid regulation of intracellular free calcium in cultured mouse dorsal root ganglion neurons.
Topics: Analgesics; Animals; Benzeneacetamides; Calcium; Cells, Cultured; Embryo, Mammalian; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Ganglia, Spinal; Kinetics; Mice; Mice, Inbred C57BL; Neurons; Potassium Chloride; Pyrrolidines; Substance P | 1996 |
The stimulatory effect of opioids on mitogen-activated protein kinase in Chinese hamster ovary cells transfected to express mu-opioid receptors.
Topics: Animals; Benzeneacetamides; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Cricetinae; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Etorphine; Morphine; Narcotics; Pertussis Toxin; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins; Transfection; Virulence Factors, Bordetella | 1996 |
Evidence for multiple opioid receptors in the human posterior pituitary.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adult; Benzeneacetamides; Binding Sites; Binding, Competitive; Cadaver; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Humans; Male; Middle Aged; Narcotics; Oligopeptides; Pituitary Gland, Posterior; Pyrrolidines; Receptors, Opioid; Tissue Distribution | 1996 |
Opioids modulate the cholinergic contraction but not the nonadrenergic relaxation in guinea-pig airways in vitro.
Topics: Animals; Benzeneacetamides; Cholinergic Fibers; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Trachea | 1996 |
Expression of mu-, delta- and kappa-opioid receptors in baculovirus-infected insect cells.
Topics: Adenylyl Cyclases; Animals; Baculoviridae; Benzeneacetamides; Cell Line; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Insecta; Kinetics; Protein Binding; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins | 1996 |
(E)- and (Z)-7-arylidenenaltrexones: synthesis and opioid receptor radioligand displacement assays.
Topics: Animals; Benzeneacetamides; Benzomorphans; Benzylidene Compounds; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Magnetic Resonance Spectroscopy; Mass Spectrometry; Models, Molecular; Molecular Conformation; Molecular Structure; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, delta; Spectroscopy, Fourier Transform Infrared | 1997 |
14 beta-Chlorocinnamoylamino derivatives of metopon: long-term mu-opioid receptor antagonists.
Topics: Analgesics; Animals; Benzeneacetamides; Binding, Competitive; Cattle; Corpus Striatum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Kinetics; Male; Mice; Mice, Inbred ICR; Morphinans; Narcotic Antagonists; Nociceptors; Pain Measurement; Pyrrolidines; Receptors, Opioid, mu; Tritium | 1997 |
A guinea pig ileum preparation devoid of functional kappa receptors: a new in vitro pharmacologic assay for mu-opioid ligands.
Topics: Acetamides; Affinity Labels; Analgesics; Animals; Benzeneacetamides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Ileum; Isothiocyanates; Male; Muscle, Smooth; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1997 |
Putative kappa-2 opioid agonists are antihyperalgesic in a rat model of inflammation.
Topics: Analgesics; Animals; Benzeneacetamides; Benzomorphans; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hyperalgesia; Male; Piperazines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa | 1997 |
Conditioned place preference: no tolerance to the rewarding properties of morphine.
Topics: Analysis of Variance; Animals; Behavior, Animal; Benzeneacetamides; Body Weight; Disease Models, Animal; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraperitoneal; Male; Morphine; Morphine Dependence; Narcotics; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1997 |
Cardiovascular effects of microinjections of opioid agonists into the 'Depressor Region' of the ventrolateral periaqueductal gray region.
Topics: Analgesics; Animals; Benzeneacetamides; Blood Pressure; Bradycardia; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Excitatory Amino Acids; Heart Rate; Homocysteine; Hypertension; Hypotension; Male; Microinjections; Neural Inhibition; Pain; Periaqueductal Gray; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1997 |
Syntheses of novel pyridazinomorphinans by inverse electron demand cycloaddition and their binding to mu and kappa receptors.
Topics: Animals; Benzeneacetamides; Binding, Competitive; Cattle; Cell Membrane; Corpus Striatum; Crystallography, X-Ray; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Indicators and Reagents; Models, Molecular; Molecular Structure; Morphinans; Pyrazines; Pyrrolidines; Radioligand Assay; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1997 |
Kappa1- and kappa2-opioid receptors mediating presynaptic inhibition of dopamine and acetylcholine release in rat neostriatum.
Topics: Acetylcholine; Animals; Benzeneacetamides; Dopamine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; In Vitro Techniques; Male; N-Methylaspartate; Naloxone; Neostriatum; Neural Inhibition; Peptide Fragments; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1997 |
The effects of postmortem delay on mu, delta and kappa opioid receptor subtypes in rat brain and guinea pig cerebellum evaluated by radioligand receptor binding.
Topics: Animals; Benzeneacetamides; Brain; Cerebellum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Kinetics; Male; Naloxone; Postmortem Changes; Pyrrolidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium | 1997 |
Binding of [3H][D-Ala2, MePhe4, Gly-ol5] enkephalin, [3H][D-Pen2, D-Pen5]enkephalin, and [3H]U-69,593 to airway and pulmonary tissues of normal and sensitized rats.
Topics: Animals; Asthma; Benzeneacetamides; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hypersensitivity, Immediate; Lung; Male; Protein Binding; Pulmonary Artery; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Respiratory System | 1997 |
Opioid modulation of extracellular signal-regulated protein kinase activity is ras-dependent and involves Gbetagamma subunits.
Topics: Animals; Benzeneacetamides; Calcium-Calmodulin-Dependent Protein Kinases; Chlorocebus aethiops; COS Cells; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Epidermal Growth Factor; GTP-Binding Proteins; Kinetics; Macromolecular Substances; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Pertussis Toxin; Pyrrolidines; ras Proteins; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins; Signal Transduction; Transfection; Virulence Factors, Bordetella | 1998 |
Substituted pyrido[3,2-b]oxazin-3(4H)-ones: synthesis and evaluation of antinociceptive activity.
Topics: Analgesics; Animals; Benzeneacetamides; Cimetidine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Histamine Antagonists; Male; Mice; Models, Chemical; Nociceptors; Oxazines; Pyridines; Pyrilamine; Pyrrolidines; Receptors, Opioid; Structure-Activity Relationship | 1998 |
Postnatal development of multiple opioid receptors in the spinal cord and development of spinal morphine analgesia.
Topics: Analgesics; Analgesics, Opioid; Animals; Autoradiography; Benzeneacetamides; Dose-Response Relationship, Drug; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Morphine; Nerve Fibers; Pyrrolidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1998 |
Affinity profiles of novel delta-receptor selective benzofuran derivatives of non-peptide opioids.
Topics: Animals; Benzeneacetamides; Benzofurans; Binding, Competitive; Brain; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Naloxone; Naltrexone; Oligopeptides; Oxycodone; Oxymorphone; Pyrrolidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Tritium | 1998 |
Role of central mu-opioid receptors in the modulation of nitric oxide production by splenocytes.
Topics: Analgesics; Analgesics, Opioid; Animals; Bacterial Toxins; Benzeneacetamides; Cell Division; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enterotoxins; Enzyme Inhibitors; Injections, Intraventricular; Lymphocytes; Male; Naltrexone; Narcotic Antagonists; Neuroimmunomodulation; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Pyrrolidines; Quaternary Ammonium Compounds; Rats; Rats, Inbred Lew; Receptors, Opioid, mu; Spleen; Superantigens | 1998 |
Selective interference of beta-arrestin 1 with kappa and delta but not mu opioid receptor/G protein coupling.
Topics: Adenylyl Cyclase Inhibitors; Amino Acid Sequence; Analgesics; Arrestins; Benzeneacetamides; beta-Arrestin 1; beta-Arrestins; Cell Line; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins; Sequence Deletion; Transfection | 1998 |
5-HT4 receptor agonists and delta-opioid receptor antagonists act synergistically to stimulate colonic propulsion.
Topics: Animals; Benzeneacetamides; Colon; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Peptide Fragments; Peristalsis; Pyrrolidines; Receptors, Opioid, delta; Receptors, Serotonin; Receptors, Serotonin, 5-HT4; Serotonin Receptor Agonists; Somatostatin | 1998 |
Axotomy reduces the effect of analgesic opioids yet increases the effect of nociceptin on dorsal root ganglion neurons.
Topics: Analgesics; Analgesics, Opioid; Animals; Axotomy; Benzeneacetamides; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Causalgia; Dihydropyridines; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ganglia, Spinal; Male; Morphine; Nerve Compression Syndromes; Neurons, Afferent; Nociceptin; omega-Conotoxin GVIA; Opioid Peptides; Peptides; Potassium; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sciatic Nerve; Sodium; Spinal Cord | 1998 |
Synthesis and biological activity of 3-substituted 3-desoxynaltrindole derivatives.
Topics: Animals; Benzeneacetamides; Binding, Competitive; Brain; Cell Membrane; Drug Design; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Molecular Structure; Naltrexone; Narcotic Antagonists; Pyrrolidines; Rats; Receptors, Opioid, delta; Structure-Activity Relationship | 1998 |
Actions of opioids on excitatory and inhibitory transmission in substantia gelatinosa of adult rat spinal cord.
Topics: Animals; Benzeneacetamides; Electric Stimulation; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Evoked Potentials; Excitatory Postsynaptic Potentials; In Vitro Techniques; Male; Membrane Potentials; Opioid Peptides; Patch-Clamp Techniques; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Substantia Gelatinosa; Synaptic Transmission | 1999 |
Opioid peptide receptor studies. 12. Buprenorphine is a potent and selective mu/kappa antagonist in the [35S]-GTP-gamma-S functional binding assay.
Topics: Animals; Benzamides; Benzeneacetamides; Buprenorphine; Drug Evaluation, Preclinical; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guinea Pigs; Male; Mice; Narcotic Antagonists; Piperazines; Putamen; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 1999 |
Dynorphin selectively augments the M-current in hippocampal CA1 neurons by an opiate receptor mechanism.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Hippocampus; In Vitro Techniques; Oligopeptides; Peptide Fragments; Potassium Channels; Pyramidal Cells; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1999 |
Opioid peptide receptor studies. 10. Nor-BNI differentially inhibits kappa receptor agonist-induced G-protein activation in the guinea pig caudate: further evidence of kappa receptor heterogeneity.
Topics: Animals; Benzeneacetamides; Benzodiazepines; Brain; Caudate Nucleus; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; In Vitro Techniques; Inhibitory Concentration 50; Naltrexone; Oligopeptides; Peptide Fragments; Peptides; Pyrrolidines; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin | 1999 |
Pharmacology of [Tyr1]nociceptin analogs: receptor binding and bioassay studies.
Topics: Amino Acid Substitution; Animals; Benzeneacetamides; Binding Sites; Binding, Competitive; Brain; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guinea Pigs; Ileum; Male; Membranes; Mice; Nociceptin; Nociceptin Receptor; Oligopeptides; Opioid Peptides; Pyrrolidines; Rabbits; Radioligand Assay; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium; Tyrosine; Vas Deferens | 1999 |
The bovine mu-opioid receptor: cloning of cDNA and pharmacological characterization of the receptor expressed in mammalian cells.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Analgesics, Opioid; Animals; Base Sequence; Benzeneacetamides; Binding, Competitive; Cattle; Cell Line; Cell Membrane; Cloning, Molecular; Colforsin; Corpus Striatum; Diprenorphine; DNA, Complementary; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Gene Expression; Gene Expression Regulation; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Molecular Sequence Data; Pyrrolidines; Radioligand Assay; Receptors, Opioid, mu; Recombinant Fusion Proteins; Sequence Alignment; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Sulfur Radioisotopes; Tritium | 1999 |
In vitro agonist effects of nociceptin and [Phe(1)psi(CH(2)-NH)Gly(2)]nociceptin(1-13)NH(2) in the mouse and rat colon and the mouse vas deferens.
Topics: Animals; Benzeneacetamides; Benzofurans; Colon; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; In Vitro Techniques; Ligands; Male; Mice; Mice, Inbred DBA; Muscle Contraction; Narcotic Antagonists; Nociceptin; Nociceptin Receptor; Opioid Peptides; Peptide Fragments; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tetrodotoxin; Vas Deferens | 1999 |
8-Aminocyclazocine analogues: synthesis and structure-activity relationships.
Topics: Analgesics; Animals; Benzeneacetamides; Binding, Competitive; Brain; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guinea Pigs; Molecular Structure; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Stereoisomerism; Structure-Activity Relationship | 2000 |
Protein kinase C-mediated acute tolerance to peripheral mu-opioid analgesia in the bradykinin-nociception test in mice.
Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Blotting, Western; Bradykinin; Dose-Response Relationship, Drug; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enzyme Inhibitors; Male; Mice; Morphine; Nociceptors; Oligonucleotides, Antisense; Pain Measurement; Peripheral Nervous System; Protein Kinase C; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2000 |
Comparison of G-protein activation in the brain by mu-, delta-, and kappa-opioid receptor agonists in mu-opioid receptor knockout mice.
Topics: Alleles; Analgesics, Opioid; Animals; Autoradiography; Benzeneacetamides; Binding, Competitive; Blotting, Southern; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sulfur Radioisotopes | 2000 |
Receptor selectivity of Met-enkephalin-Arg6-Phe7, an endogenous opioid peptide, in cerebral cortex of human and rat.
Topics: Adult; Animals; Benzeneacetamides; Benzomorphans; Binding Sites; Cerebral Cortex; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Ethylketocyclazocine; Female; Humans; Male; Naloxone; Naltrexone; Norepinephrine; Oligopeptides; Peptide Fragments; Peptides; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Somatostatin | 2000 |
Evidence for transduction of mu but not kappa opioid modulation of extracellular signal-regulated kinase activity by G(z) and G(12) proteins.
Topics: Analgesics; Analgesics, Opioid; Animals; Benzeneacetamides; COS Cells; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Activation; Fatty Acids; GTP-Binding Proteins; Immunoblotting; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; Pertussis Toxin; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Time Factors; Transduction, Genetic; Virulence Factors, Bordetella | 2000 |
Inverse agonism by Dmt-Tic analogues and HS 378, a naltrindole analogue.
Topics: Benzamides; Benzeneacetamides; Binding, Competitive; Cell Line; Cell Membrane; Dipeptides; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Isoquinolines; Naltrexone; Narcotic Antagonists; Piperazines; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sulfur Radioisotopes; Tetrahydroisoquinolines | 2000 |
Selective kappa-opioid antagonists related to naltrindole. Effect of side-chain spacer in the 5'-amidinoalkyl series.
Topics: Amidines; Animals; Benzeneacetamides; Binding, Competitive; Brain; Cell Membrane; Drug Design; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Guinea Pigs; Indicators and Reagents; Kinetics; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, kappa; Structure-Activity Relationship | 2000 |
Interference of biocytin with opioid-evoked hyperpolarization and membrane properties of rat spinal substantia gelatinosa neurons.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Benzeneacetamides; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Lysine; Membrane Potentials; Organ Culture Techniques; Patch-Clamp Techniques; Pyrrolidines; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Substantia Gelatinosa | 2001 |
Cyclic AMP regulates the calcium transients released from IP(3)-sensitive stores by activation of rat kappa-opioid receptors expressed in CHO cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 8-Bromo Cyclic Adenosine Monophosphate; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Benzeneacetamides; Bucladesine; Calcium; Calcium Signaling; CHO Cells; Cloning, Molecular; Colforsin; Cricetinae; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enzyme Inhibitors; Gene Expression; Inositol 1,4,5-Trisphosphate; Peptides; Pyrrolidines; Rats; Receptors, Opioid, kappa; Thionucleotides; Transfection | 2001 |
Opioids suppress basal and nicotine-induced catecholamine secretion via a stabilizing effect on actin filaments.
Topics: Actins; Animals; Benzeneacetamides; Cytochalasin B; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Humans; Naltrexone; Narcotics; Nicotine; Norepinephrine; PC12 Cells; Pyrrolidines; Rats | 2001 |
SoRI 9409, a non-peptide opioid mu receptor agonist/delta receptor antagonist, fails to stimulate [35S]-GTP-gamma-S binding at cloned opioid receptors.
Topics: Analgesics; Analgesics, Opioid; Animals; Benzamides; Benzeneacetamides; Binding, Competitive; CHO Cells; Cloning, Molecular; Cricetinae; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Iodine Radioisotopes; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Piperazines; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sulfur Radioisotopes; Tritium | 2001 |
Morphine acutely and persistently attenuates nonvesicular GABA release in rat nucleus accumbens.
Topics: Analgesics; Animals; Benzeneacetamides; Carrier Proteins; Dopamine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Male; Morphine; Morphine Dependence; N-Methylaspartate; Naloxone; Neural Inhibition; Neurons; Nucleus Accumbens; Organ Culture Techniques; Pyrrolidines; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Tritium | 2001 |
Predominance of delta-opioid-binding sites in the porcine enteric nervous system.
Topics: Animals; Benzeneacetamides; Binding Sites; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enteric Nervous System; Female; In Vitro Techniques; Intestinal Mucosa; Intestines; Male; Myenteric Plexus; Naltrexone; Narcotic Antagonists; Neurons; Pyrrolidines; Radioligand Assay; Radiopharmaceuticals; Receptors, Opioid, delta; Saxitoxin; Swine | 2002 |
mu/delta Cooperativity and opposing kappa-opioid effects in nucleus accumbens-mediated antinociception in the rat.
Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Capsaicin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Male; Narcotic Antagonists; Neurons; Nociceptors; Nucleus Accumbens; Pain; Pyrrolidines; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex | 2002 |
Characterization of mu, kappa, and delta opioid binding in amphibian whole brain tissue homogenates.
Topics: Animals; Benzeneacetamides; Binding, Competitive; Brain Chemistry; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; In Vitro Techniques; Kinetics; Membranes; Pyrrolidines; Radioligand Assay; Rana pipiens; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2002 |
Sympathetic denervation-induced changes in G protein expression in enteric neurons of the guinea pig colon.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Animals; Autonomic Denervation; Benzeneacetamides; Brimonidine Tartrate; Cell Fractionation; Colon; Drug Antagonism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; GTP-Binding Proteins; Guinea Pigs; In Vitro Techniques; Myenteric Plexus; Pertussis Toxin; Pyrrolidines; Quinoxalines; Receptors, Opioid; Synaptosomes; Virulence Factors, Bordetella | 2002 |
The effect of opioid agonists of delta-class DSLET, mu-class DAMGO, kappa-class U-69593 and an opioid antagonist, naloxone, on MTT activity of NALM-1 leukemic cells.
Topics: Benzeneacetamides; Cell Division; Cell Survival; Colorimetry; DNA Fragmentation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Humans; Leukemia; Naloxone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 2002 |
Naloxone and its quaternary derivative, naloxone methiodide, have differing affinities for mu, delta, and kappa opioid receptors in mouse brain homogenates.
Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Male; Mice; Naloxone; Narcotic Antagonists; Pyrrolidines; Quaternary Ammonium Compounds; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium | 2003 |
Cellular actions of opioids on periaqueductal grey neurons from C57B16/J mice and mutant mice lacking MOR-1.
Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Female; GABA-A Receptor Antagonists; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Oligopeptides; Patch-Clamp Techniques; Periaqueductal Gray; Potassium Channels, Inwardly Rectifying; Pyrrolidines; Receptors, GABA-A; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Synaptic Transmission | 2003 |
Development of antinociceptive tolerance and changes of opioid receptor ligand binding in central nervous system of the mouse forced to single and repeated swimming in the cold water.
Topics: Analgesics; Analgesics, Opioid; Animals; Benzeneacetamides; Binding Sites; Central Nervous System; Cold Temperature; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Male; Mice; Mice, Inbred ICR; Pain Measurement; Pyrrolidines; Receptors, Opioid; Swimming; Time Factors | 2003 |
Presynaptic mechanism for anti-analgesic and anti-hyperalgesic actions of kappa-opioid receptors.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Benzeneacetamides; Cells, Cultured; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Hyperalgesia; Male; Patch-Clamp Techniques; Pyrrolidines; Raphe Nuclei; Rats; Rats, Wistar; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, Presynaptic; Synaptic Transmission | 2003 |
DPI-3290 [(+)-3-((alpha-R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide]. I. A mixed opioid agonist with potent antinociceptive activity.
Topics: Analgesics; Animals; Benzamides; Benzeneacetamides; Binding, Competitive; Blood Gas Analysis; Brain Chemistry; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Guinea Pigs; Ileum; Male; Muscle, Smooth; Narcotic Antagonists; Narcotics; Pain Measurement; Piperazines; Pyrrolidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stereoisomerism; Vas Deferens | 2003 |
Kappa-opioid agonists directly inhibit midbrain dopaminergic neurons.
Topics: Analgesics; Animals; Benzeneacetamides; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; In Vitro Techniques; Male; Mesencephalon; Naltrexone; Narcotic Antagonists; Neural Inhibition; Neurons; Patch-Clamp Techniques; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Ventral Tegmental Area | 2003 |
Morphine prevents glutamate-induced death of primary rat neonatal astrocytes through modulation of intracellular redox.
Topics: Acetylcysteine; Animals; Animals, Newborn; Apoptosis; Astrocytes; Benzeneacetamides; Benzimidazoles; Bisbenzimidazole; Carbocyanines; Cell Line, Tumor; Cell Nucleus; Cell Survival; Cells, Cultured; Dizocilpine Maleate; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Glutamic Acid; Glutathione; Hydrogen Peroxide; Ion Channels; Microscopy, Fluorescence; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Morphine; Naloxone; Narcotic Antagonists; Neuroglia; Oxidation-Reduction; Oxidative Stress; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Rhodamine 123 | 2004 |
Activation of mu opioid receptors in the ventrolateral periaqueductal gray inhibits reflex micturition in anesthetized rats.
Topics: Administration, Intravesical; Anesthetics; Animals; Benzeneacetamides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Female; Microinjections; Morphine; Muscle Contraction; Narcotics; Periaqueductal Gray; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex; Sodium Chloride; Urinary Bladder; Urination | 2004 |
Opioid receptors in fast and slow skeletal muscles of normal and dystrophic mice.
Topics: Analysis of Variance; Animals; Autoradiography; Benzeneacetamides; beta-Endorphin; Binding Sites; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Iodine Isotopes; Mice; Mice, Inbred C57BL; Muscle Fibers, Fast-Twitch; Muscle Fibers, Slow-Twitch; Muscle, Skeletal; Muscular Dystrophy, Animal; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2004 |
Both kappa and mu opioid agonists inhibit glutamatergic input to ventral tegmental area neurons.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Benzeneacetamides; Drug Interactions; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Male; Neural Inhibition; Neurons; Patch-Clamp Techniques; Pyrrolidines; Rats; Rats, Sprague-Dawley; Time Factors; Ventral Tegmental Area | 2005 |
delta-opioid receptor-mediated actions on rostral ventromedial medulla neurons.
Topics: Analgesics, Opioid; Animals; Animals, Newborn; Benzeneacetamides; Calcium Channels; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Immunohistochemistry; In Vitro Techniques; Lysine; Male; Medulla Oblongata; Membrane Potentials; Narcotic Antagonists; Neurons; Oligopeptides; Patch-Clamp Techniques; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Serotonin; Substance P; Tryptophan Hydroxylase | 2005 |
Mu and kappa opioid receptors activate ERK/MAPK via different protein kinase C isoforms and secondary messengers in astrocytes.
Topics: Analgesics; Analgesics, Opioid; Animals; Astrocytes; Benzeneacetamides; Calcium; Calmodulin; Carbazoles; Cell Membrane; Cells, Cultured; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Activation; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Humans; Immunoblotting; Immunoprecipitation; Indoles; Maleimides; MAP Kinase Signaling System; Neurons; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Binding; Protein Isoforms; Protein Kinase C; Protein Kinase C-epsilon; Pyrrolidines; Rats; Receptors, Opioid, kappa; Receptors, Opioid, mu; Signal Transduction; Transfection; Type C Phospholipases | 2005 |
Nalmefene induced elevation in serum prolactin in normal human volunteers: partial kappa opioid agonist activity?
Topics: Adolescent; Adult; Analgesics, Opioid; Animals; Benzeneacetamides; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Estradiol; Female; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Naltrexone; Narcotic Antagonists; Prolactin; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2005 |
N-substituted cis-4a-(3-hydroxyphenyl)-8a-methyloctahydroisoquinolines are opioid receptor pure antagonists.
Topics: Animals; Benzeneacetamides; CHO Cells; Cricetinae; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Isoquinolines; Models, Molecular; Molecular Conformation; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2005 |
Functional interaction between alpha2-adrenoceptors, mu- and kappa-opioid receptors in the guinea pig myenteric plexus: effect of chronic desipramine treatment.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Analgesics; Analgesics, Opioid; Animals; Antidepressive Agents, Tricyclic; Benzeneacetamides; Blotting, Western; Brimonidine Tartrate; Desipramine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; G Protein-Coupled Inwardly-Rectifying Potassium Channels; GTP-Binding Proteins; Guinea Pigs; In Vitro Techniques; Male; Myenteric Plexus; Peristalsis; Pyrrolidines; Quinoxalines; Receptors, Adrenergic, alpha-2; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Synaptosomes | 2006 |
The in vitro pharmacology of the peripherally restricted opioid receptor antagonists, alvimopan, ADL 08-0011 and methylnaltrexone.
Topics: Analgesics, Opioid; Animals; Benzeneacetamides; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Naltrexone; Narcotic Antagonists; Oligopeptides; Piperidines; Pyrrolidines; Quaternary Ammonium Compounds; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins; Transfection | 2007 |
Acute amphetamine exposure selectively desensitizes kappa-opioid receptors in the nucleus accumbens.
Topics: Amphetamine; Analgesics, Opioid; Analysis of Variance; Animals; Benzeneacetamides; Central Nervous System Stimulants; Dopamine Agents; Dose-Response Relationship, Drug; Drug Interactions; Dynorphins; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Excitatory Postsynaptic Potentials; Gene Expression Regulation; Male; Narcotic Antagonists; Nucleus Accumbens; Patch-Clamp Techniques; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2008 |
Opioid regulation of spinal cord plasticity: evidence the kappa-2 opioid receptor agonist GR89696 inhibits learning within the rat spinal cord.
Topics: Adaptation, Physiological; Animals; Association Learning; Benzeneacetamides; Conditioning, Operant; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Male; Neuronal Plasticity; Neurons; Neurotransmitter Agents; Piperazines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Spinal Cord; Spinal Cord Injuries; Thoracic Vertebrae | 2008 |
Displacement of opioid receptor binding ligands from the rat brain by N3-(2',5'-dimethoxyphenacyl) arabinofuranosyluracil.
Topics: Analgesics, Opioid; Animals; Arabinofuranosyluracil; Autoradiography; Benzeneacetamides; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Injections, Intraventricular; Ligands; Male; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2005 |
Activation of micro, delta or kappa opioid receptors by DAMGO, DPDPE, U-50488 or U-69593 respectively causes antinociception in the formalin test in the naked mole-rat (Heterocephalus glaber).
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Benzeneacetamides; Data Interpretation, Statistical; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Formaldehyde; Injections, Intraperitoneal; Male; Mole Rats; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Pyrrolidines; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2009 |
Morphine enhances microglial migration through modulation of P2X4 receptor signaling.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Benzeneacetamides; Calcium-Binding Proteins; Cell Movement; Cells, Cultured; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Inhibitors; Gene Expression Regulation; Microfilament Proteins; Microglia; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2X4; Signal Transduction; Time Factors | 2009 |
Effects of opioid receptor activation on thermal antinociception in red-eared slider turtles (Trachemys scripta).
Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Cross-Over Studies; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Female; Hot Temperature; Male; Nociceptors; Pyrrolidines; Receptors, Opioid, mu; Sodium Chloride; Turtles | 2009 |
Mu and kappa opioids modulate mouse embryonic stem cell-derived neural progenitor differentiation via MAP kinases.
Topics: Analgesics, Opioid; Animals; Antigens; Benzeneacetamides; Cell Differentiation; Cells, Cultured; Drug Interactions; Embryo, Mammalian; Embryonic Stem Cells; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Mice; Mitogen-Activated Protein Kinase Kinases; Naltrexone; Narcotic Antagonists; Oligodendroglia; Peptides; Proteoglycans; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Time Factors; Tretinoin; Tubulin | 2010 |
Differential expression and sensitivity of presynaptic and postsynaptic opioid receptors regulating hypothalamic proopiomelanocortin neurons.
Topics: Analgesics; Analgesics, Opioid; Analysis of Variance; Animals; Benzeneacetamides; Dizocilpine Maleate; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Gene Expression; Hypothalamus; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Luminescent Proteins; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; Naltrexone; Narcotic Antagonists; Neural Inhibition; Neurons; Patch-Clamp Techniques; Peptide Fragments; Pro-Opiomelanocortin; Pyrrolidines; Quinoxalines; Receptors, Opioid; Somatostatin; Synapses | 2011 |
Standard opioid agonists activate heteromeric opioid receptors: evidence for morphine and [d-Ala(2)-MePhe(4)-Glyol(5)]enkephalin as selective μ-δ agonists.
Topics: Analgesics, Opioid; Area Under Curve; Benzeneacetamides; Calcium Signaling; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Guanosine 5'-O-(3-Thiotriphosphate); HEK293 Cells; Humans; Immunohistochemistry; Ligands; Morphine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2010 |
Opposite effects of neuropeptide FF on central antinociception induced by endomorphin-1 and endomorphin-2 in mice.
Topics: Adamantane; Animals; Benzeneacetamides; Dipeptides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Injections, Intraventricular; Male; Mice; Naltrexone; Nociception; Oligopeptides; Pyrrolidines | 2014 |
Peroxiredoxin 6 mediates Gαi protein-coupled receptor inactivation by cJun kinase.
Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Fentanyl; GTP-Binding Protein alpha Subunits, Gi-Go; JNK Mitogen-Activated Protein Kinases; Mice; Morphine; NADPH Oxidases; Peroxiredoxin VI; Phosphorylation; Pyrrolidines; Reactive Oxygen Species; Receptors, Dopamine D2; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2017 |