u 69593 has been researched along with dynorphins in 51 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (5.88) | 18.7374 |
| 1990's | 28 (54.90) | 18.2507 |
| 2000's | 13 (25.49) | 29.6817 |
| 2010's | 7 (13.73) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dziedzicka, M; Lasoń, W; Przewłocka, B; Przewłocki, R | 1 |
| Caudle, RM; Chavkin, C; Wagner, JJ | 1 |
| Leslie, FM; Loughlin, SE; Smith, JA | 1 |
| Chavkin, C; Evans, CJ; Wagner, JJ | 1 |
| Kinouchi, K; Pasternak, GW | 1 |
| Caliezi, A; Drack, E; Halter, F; Scheurer, U; Varga, L; Wenger, F | 1 |
| Devlin, T; Shoemaker, WJ | 1 |
| Alzheimer, C; ten Bruggencate, G | 1 |
| Rodriguez, FD; Traynor, JR; Wood, MS | 1 |
| De Montis, GM; Devoto, P; Preti, A; Tagliamonte, A | 1 |
| Berzetei, IP; Duckles, SP; Fong, A; Yamamura, HI | 1 |
| Kuznetsov, A; Ma, GH; Miller, RJ; Philipson, LH | 1 |
| Grudt, TJ; Williams, JT | 1 |
| Chavkin, C; Terman, GW; Wagner, JJ | 2 |
| Faden, AI; Fernyak, S; McIntosh, TK; Yamakami, I | 1 |
| Macdonald, RL; Moises, HC; Rusin, KI | 1 |
| Chen, C; DeRiel, JK; Kunapuli, S; Liu-Chen, LY; Xue, JC; Yu, L; Zhu, J | 1 |
| Glaum, SR; Miller, RJ; Rhim, H | 1 |
| Davis, P; DeLeon, IA; Hruby, VJ; Li, G; Lou, BS; Lung, FD; Meyer, JP; Porreca, F; Xiang, L; Yamamura, HI | 1 |
| Archer, S; Bidlack, JM; Bu, DF; Chao, CC; Gekker, G; Hu, S; Peterson, PK; Shark, KB; Sheng, WS | 1 |
| Frankhuijzen-Sierevogel, JC; Janssen, S; Maigret, C; van de Heijning, BJ; van Wimersma Greidanus, TB | 1 |
| Inderbitzin, S; Lauber, ME; Lichtensteiger, W; Schlumpf, M | 1 |
| Blake, AD; Bot, G; Freeman, JC; Li, S; Reisine, T | 1 |
| Brines, ML; de Lanerolle, NC; Kim, JH; Meredith, C; Spencer, DD; Tabuteau, H; Williamson, A | 1 |
| Hogenboom, F; Mulder, AH; Schoffelmeer, AN | 1 |
| Ling, K; Ma, L; Pei, G | 1 |
| Foxx-Orenstein, AE; Grider, JR; Jin, JG | 1 |
| Madamba, SG; Schweitzer, P; Siggins, GR | 1 |
| Chavkin, C; Drake, CT; Milner, TA; Simmons, ML; Terman, GW | 1 |
| McGinty, JF; Tzaferis, JA | 1 |
| Horie, S; Ishihara, S; Minowa, S; Murayama, T; Tsuchiya, S; Watanabe, K | 1 |
| Ball, JW; Butelman, ER; Harris, TJ; Kreek, MJ | 1 |
| Bie, B; Pan, ZZ | 1 |
| Ball, JW; Butelman, ER; Kreek, MJ | 1 |
| Carlezon, WA; Marcus, JF; Portoghese, PS; Todtenkopf, MS | 1 |
| Candeletti, S; D'Addario, C; Di Benedetto, M; Izenwasser, S; Romualdi, P | 2 |
| Chefer, VI; Shippenberg, TS | 1 |
| He, L; Hjelmstad, GO; Whistler, JL; Xia, YF | 1 |
| Bains, JS; Iremonger, KJ | 1 |
| Hadjiconstantinou, M; McCarthy, MJ; Neff, NH; Zhang, H | 1 |
| McDermott, CM; Schrader, LA | 1 |
| Burger, LL; Moenter, SM; Ruka, KA | 1 |
| Gilpin, NW; Koob, GF; Roberto, M; Schweitzer, P | 1 |
| Aldrich, JV; Cowan, A; Dimattio, KM; Liu-Chen, LY; Yakovleva, TV | 1 |
| Aubé, J; Bohn, LM; Frankowski, KJ; Lovell, KM; Prisinzano, TE; Stahl, EL; Zhou, L | 1 |
| Akil, H; Goldstein, A; Mansour, A; Meng, F; Thompson, RC; Watson, SJ; Xie, GX | 1 |
| Adapa, ID; Auh, JS; Berzetei-Gurske, IP; Brandt, SR; Craymer, K; Farrington, L; Haggart, D; Kennedy, JM; O'Brien, A; Polgar, WE; Rodriguez, L; Schwartz, RW; Toll, L; White, A | 1 |
| Ferguson, DM; Kramer, S; Law, PY; Metzger, TG; Portoghese, PS | 1 |
| Aubé, J; Frankowski, KJ; Katritch, V; Mosier, PD; Roth, BL; Stevens, RC; Vardy, E; Westkaemper, RB; Wu, H | 1 |
51 other study(ies) available for u 69593 and dynorphins
| Article | Year |
|---|---|
Differential effects of opioid receptor agonists on nociception and cAMP level in the spinal cord of monoarthritic rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Arthritis; Benzeneacetamides; Colforsin; Cyclic AMP; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guanylyl Imidodiphosphate; Injections, Spinal; Male; Morphine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord | 1992 |
Kappa-opioids decrease excitatory transmission in the dentate gyrus of the guinea pig hippocampus.
Topics: Action Potentials; Animals; Benzeneacetamides; Diprenorphine; Dynorphins; Electrophysiology; Endorphins; Guinea Pigs; Hippocampus; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Synapses | 1992 |
kappa-Opioid inhibition of [3H]dopamine release from rat ventral mesencephalic dissociated cell cultures.
Topics: Animals; Benzeneacetamides; Calcium; Cells, Cultured; Dopamine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Mesencephalon; Narcotics; Potassium; Pyrrolidines; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tetrodotoxin | 1992 |
Focal stimulation of the mossy fibers releases endogenous dynorphins that bind kappa 1-opioid receptors in guinea pig hippocampus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Benzeneacetamides; Binding Sites; Dynorphins; Electric Stimulation; Guinea Pigs; Hippocampus; Immune Sera; Male; Nerve Fibers; Protease Inhibitors; Pyrrolidines; Quinoxalines; Receptors, Opioid; Receptors, Opioid, kappa; Tissue Distribution; Veratridine | 1991 |
Evidence for kappa 1 opioid receptor multiplicity in the guinea pig cerebellum.
Topics: Animals; Benzeneacetamides; Binding Sites; Binding, Competitive; Cerebellum; Dynorphins; Ethylketocyclazocine; Guinea Pigs; In Vitro Techniques; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Tritium | 1991 |
Different motor actions of dynorphins and nonpeptide kappa opioid receptor agonists in the isolated rat colon.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Antihypertensive Agents; Benzeneacetamides; Benzodiazepines; Benzomorphans; Colon; Diuretics; Dynorphins; Gastrointestinal Motility; In Vitro Techniques; Male; Muscle, Smooth; Naloxone; Narcotic Antagonists; Pressure; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1990 |
Characterization of kappa opioid binding using dynorphin A1-13 and U69,593 in the rat brain.
Topics: Analgesics; Animals; Benzeneacetamides; Benzomorphans; Binding, Competitive; Brain; Culture Techniques; Dynorphins; Ligands; Male; Morphinans; Peptide Fragments; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Tritium | 1990 |
Nonopioid actions of the kappa-opioid receptor agonists, U 50488H and U 69593 on electrophysiologic properties of hippocampal CA3 neurons in vitro.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzeneacetamides; Dynorphins; Guinea Pigs; Hippocampus; In Vitro Techniques; Membrane Potentials; Naloxone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa | 1990 |
Characterisation of kappa-opioid binding sites in rat and guinea-pig spinal cord.
Topics: Animals; Benzeneacetamides; Benzomorphans; Captopril; Diprenorphine; Dynorphins; Guinea Pigs; In Vitro Techniques; Leucine; Ligands; Male; Peptide Fragments; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Spinal Cord | 1989 |
Differential effect of mu, delta, and kappa opioid agonists on adenylate cyclase activity.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclases; Analgesics; Animals; Benzeneacetamides; Benzomorphans; Corpus Striatum; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Male; Morphinans; Peptide Fragments; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid | 1987 |
Characterization of kappa opioid receptors in the rabbit ear artery.
Topics: Animals; Benzeneacetamides; Benzomorphans; Cyclazocine; Dynorphins; Ethylketocyclazocine; In Vitro Techniques; Male; Mice; Muscle, Smooth, Vascular; Narcotic Antagonists; Peptide Fragments; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1988 |
kappa-Opioid receptor activates an inwardly rectifying K+ channel by a G protein-linked mechanism: coexpression in Xenopus oocytes.
Topics: Animals; Benzeneacetamides; Cloning, Molecular; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Gene Expression; GTP-Binding Proteins; In Vitro Techniques; Mice; Naloxone; Naltrexone; Oocytes; Pertussis Toxin; Potassium Channels; Pyrrolidines; Receptors, Opioid, kappa; RNA, Complementary; Virulence Factors, Bordetella; Xenopus | 1995 |
kappa-Opioid receptors also increase potassium conductance.
Topics: Animals; Benzeneacetamides; Dynorphins; Electric Conductivity; Guinea Pigs; In Vitro Techniques; Ion Channel Gating; Male; Membrane Potentials; Naltrexone; Potassium Channels; Pyrrolidines; Receptors, Opioid, kappa; Trigeminal Nuclei | 1993 |
Kappa opioids inhibit induction of long-term potentiation in the dentate gyrus of the guinea pig hippocampus.
Topics: Animals; Benzeneacetamides; Dynorphins; Electric Stimulation; Guinea Pigs; Hippocampus; Long-Term Potentiation; Male; Naloxone; Naltrexone; Pyrrolidines; Receptors, Opioid, kappa; Synaptic Transmission | 1994 |
Central and systemic kappa-opioid agonists exacerbate neurobehavioral response to brain injury in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Animal; Benzeneacetamides; Brain; Brain Injuries; Cardiovascular System; Dynorphins; Injections, Intravenous; Injections, Intraventricular; Male; Movement Disorders; Nervous System; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Survival Analysis | 1994 |
Mu- and kappa-opioid receptors selectively reduce the same transient components of high-threshold calcium current in rat dorsal root ganglion sensory neurons.
Topics: Analgesics; Animals; Benzeneacetamides; Calcium; Calcium Channels; Dynorphins; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Evoked Potentials; Ganglia, Spinal; In Vitro Techniques; Naloxone; Naltrexone; Narcotic Antagonists; Neurons, Afferent; Pyrrolidines; Rats; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reference Values; Sensitivity and Specificity | 1994 |
Differential binding domains of peptide and non-peptide ligands in the cloned rat kappa opioid receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Animals; Base Sequence; Benzeneacetamides; Binding Sites; Binding, Competitive; Cell Line; Chlorocebus aethiops; Cloning, Molecular; Diprenorphine; DNA Primers; Dynorphins; Endorphins; Kinetics; Ligands; Molecular Sequence Data; Naltrexone; Polymerase Chain Reaction; Protein Conformation; Protein Structure, Secondary; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Fusion Proteins; Transfection | 1994 |
Selective opioid agonists modulate afferent transmission in the rat nucleus tractus solitarius.
Topics: Action Potentials; Afferent Pathways; Analgesics; Animals; Benzeneacetamides; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Medulla Oblongata; Potassium Channels; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Synaptic Transmission | 1993 |
Endogenous dynorphins inhibit excitatory neurotransmission and block LTP induction in the hippocampus.
Topics: Action Potentials; Animals; Benzeneacetamides; Dynorphins; Glutamates; Glutamic Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; Naltrexone; Neural Inhibition; Neurotransmitter Agents; Pyrrolidines; Receptors, Opioid, kappa; Synapses; Time Factors | 1993 |
Effects of modifications of residues in position 3 of dynorphin A(1-11)-NH2 on kappa receptor selectivity and potency.
Topics: Amino Acid Sequence; Analgesics; Animals; Benzeneacetamides; Brain; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Ileum; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Peptide Fragments; Protein Binding; Protein Conformation; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship | 1996 |
kappa opioid receptors in human microglia downregulate human immunodeficiency virus 1 expression.
Topics: Analgesics; Base Sequence; Benzeneacetamides; Brain; Cell Membrane; Cells, Cultured; DNA, Complementary; Dynorphins; Fetus; Fluorescent Antibody Technique, Indirect; HIV-1; Humans; Kinetics; Microglia; Molecular Sequence Data; Open Reading Frames; Peptide Fragments; Phycoerythrin; Pyrrolidines; Receptors, Opioid, kappa; RNA, Messenger; Transcription, Genetic; Virus Replication | 1996 |
Effect of central administration of the kappa-opiate receptor agonist U 69.593 on neurohypophyseal hormone levels in blood and cerebrospinal fluid.
Topics: Analgesics; Animals; Arginine Vasopressin; Benzeneacetamides; beta-Endorphin; Depression, Chemical; Dynorphins; Male; Oxytocin; Pituitary Gland, Posterior; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Water Deprivation | 1996 |
Amphetamine-induced preprodynorphin mRNA expression and kappa-opioid receptor binding in basal ganglia of adult rats after prenatal exposure to diazepam.
Topics: Age Factors; Amphetamine; Analgesics; Animals; Basal Ganglia; Benzeneacetamides; Binding, Competitive; Diazepam; Dynorphins; Female; GABA Modulators; Gene Expression; In Situ Hybridization; Male; Pregnancy; Prenatal Exposure Delayed Effects; Protein Precursors; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid, kappa; RNA, Messenger; Sympathomimetics; Tritium | 1997 |
Differential agonist regulation of the human kappa-opioid receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylate Cyclase Toxin; Benzeneacetamides; Cell Line; Cyclic AMP; Diprenorphine; Dynorphins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Levorphanol; Narcotic Antagonists; Narcotics; Pertussis Toxin; Pyrrolidines; Receptors, Opioid, kappa; Virulence Factors, Bordetella | 1997 |
Dynorphin and the kappa 1 ligand [3H]U69,593 binding in the human epileptogenic hippocampus.
Topics: Adolescent; Adult; Benzeneacetamides; Binding Sites; Cell Count; Dynorphins; Epilepsy, Temporal Lobe; Female; Hippocampus; Humans; Male; Middle Aged; Naloxone; Neurons; Pyrrolidines; Receptors, Opioid, kappa; Tritium | 1997 |
Kappa1- and kappa2-opioid receptors mediating presynaptic inhibition of dopamine and acetylcholine release in rat neostriatum.
Topics: Acetylcholine; Animals; Benzeneacetamides; Dopamine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylketocyclazocine; In Vitro Techniques; Male; N-Methylaspartate; Naloxone; Neostriatum; Neural Inhibition; Peptide Fragments; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1997 |
Differential efficacies of kappa agonists to induce homologous desensitization of human kappa opioid receptor.
Topics: Animals; Benzeneacetamides; CHO Cells; Cricetinae; Dynorphins; Etorphine; Extracellular Space; Humans; Hydrogen-Ion Concentration; Pyrrolidines; Receptors, Opioid, kappa | 1998 |
5-HT4 receptor agonists and delta-opioid receptor antagonists act synergistically to stimulate colonic propulsion.
Topics: Animals; Benzeneacetamides; Colon; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Peptide Fragments; Peristalsis; Pyrrolidines; Receptors, Opioid, delta; Receptors, Serotonin; Receptors, Serotonin, 5-HT4; Serotonin Receptor Agonists; Somatostatin | 1998 |
Dynorphin selectively augments the M-current in hippocampal CA1 neurons by an opiate receptor mechanism.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Hippocampus; In Vitro Techniques; Oligopeptides; Peptide Fragments; Potassium Channels; Pyramidal Cells; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1999 |
Opioid modulation of recurrent excitation in the hippocampal dentate gyrus.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Axons; Benzeneacetamides; Dendrites; Dentate Gyrus; Dynorphins; Guinea Pigs; In Vitro Techniques; Long-Term Potentiation; Male; Nerve Fibers; Neurons; Pyrrolidines; Receptors, GABA-A; Receptors, Opioid, kappa; Synapses | 2000 |
Kappa opioid receptor stimulation decreases amphetamine-induced behavior and neuropeptide mRNA expression in the striatum.
Topics: Amphetamine; Analgesics; Animals; Behavior, Animal; Benzeneacetamides; Central Nervous System Stimulants; Corpus Striatum; Dynorphins; Enkephalins; Gene Expression; In Situ Hybridization; Male; Neuropeptides; Protein Precursors; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; RNA, Messenger; Stimulation, Chemical; Substance P | 2001 |
Involvement of glutamate and gamma-amino-butyric acid receptor systems on gastric acid secretion induced by activation of kappa-opioid receptors in the central nervous system in rats.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Baclofen; Benzeneacetamides; Benzomorphans; Bicuculline; Brain; Dynorphins; gamma-Aminobutyric Acid; Gastric Acid; Injections, Intraventricular; Ketanserin; Male; Perfusion; Piperazines; Pyrrolidines; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa; Receptors, Serotonin; Stomach | 2003 |
Topical capsaicin-induced allodynia in unanesthetized primates: pharmacological modulation.
Topics: Aminobutyrates; Analgesics; Animals; Benzeneacetamides; Capsaicin; Disease Models, Animal; Dizocilpine Maleate; Dynorphins; Female; Ketamine; Macaca mulatta; Pain; Pain Measurement; Peptide Fragments; Pyrrolidines | 2003 |
Presynaptic mechanism for anti-analgesic and anti-hyperalgesic actions of kappa-opioid receptors.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Benzeneacetamides; Cells, Cultured; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Hyperalgesia; Male; Patch-Clamp Techniques; Pyrrolidines; Raphe Nuclei; Rats; Rats, Wistar; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, Presynaptic; Synaptic Transmission | 2003 |
Peripheral selectivity and apparent efficacy of dynorphins: comparison to non-peptidic kappa-opioid agonists in rhesus monkeys.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Benzeneacetamides; Blood-Brain Barrier; Discrimination Learning; Dose-Response Relationship, Drug; Dynorphins; Female; Hypothalamus; Injections, Intravenous; Macaca mulatta; Male; Naltrexone; Neurosecretory Systems; Peptide Fragments; Prolactin; Pyrrolidines; Receptors, Opioid, kappa | 2004 |
Effects of kappa-opioid receptor ligands on intracranial self-stimulation in rats.
Topics: Animals; Behavior, Animal; Benzeneacetamides; Brain; Dose-Response Relationship, Drug; Drug Interactions; Dynorphins; Electric Stimulation; Electrodes, Implanted; Injections, Intraperitoneal; Ligands; Male; Naltrexone; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reward; Self Stimulation; Time Factors | 2004 |
Differential time course of effects of kappa-opioid agonist treatment on dynorphin A levels and kappa-opioid receptor density.
Topics: Analgesics; Animals; Benzeneacetamides; Brain; Dynorphins; Male; Pyrrolidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Time Factors | 2004 |
Paradoxical effects of prodynorphin gene deletion on basal and cocaine-evoked dopaminergic neurotransmission in the nucleus accumbens.
Topics: Analgesics; Animals; Area Under Curve; Behavior, Animal; Benzeneacetamides; Chromatography, High Pressure Liquid; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Dynorphins; Electrochemistry; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Motor Activity; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Pyrrolidines | 2006 |
Role of serotonin in the regulation of the dynorphinergic system by a kappa-opioid agonist and cocaine treatment in rat CNS.
Topics: Animals; Benzeneacetamides; Blotting, Northern; Central Nervous System; Cocaine; Dynorphins; Enkephalins; Fluoxetine; Hippocampus; Hypothalamus; Male; Neostriatum; Protein Precursors; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; RNA Probes; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Serotonin | 2007 |
Acute amphetamine exposure selectively desensitizes kappa-opioid receptors in the nucleus accumbens.
Topics: Amphetamine; Analgesics, Opioid; Analysis of Variance; Animals; Benzeneacetamides; Central Nervous System Stimulants; Dopamine Agents; Dose-Response Relationship, Drug; Drug Interactions; Dynorphins; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Excitatory Postsynaptic Potentials; Gene Expression Regulation; Male; Narcotic Antagonists; Nucleus Accumbens; Patch-Clamp Techniques; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2008 |
Retrograde opioid signaling regulates glutamatergic transmission in the hypothalamus.
Topics: 4-Aminopyridine; Analysis of Variance; Animals; Animals, Genetically Modified; Animals, Newborn; Benzeneacetamides; Calcium; Calcium Channel Blockers; Dendrites; Dynorphins; Electric Stimulation; Enzyme Inhibitors; Glutamic Acid; Green Fluorescent Proteins; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Male; Narcotic Antagonists; Neural Inhibition; Neural Pathways; Neurons; omega-Conotoxin GVIA; Paraventricular Hypothalamic Nucleus; Patch-Clamp Techniques; Potassium Channel Blockers; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Signal Transduction; Synaptic Transmission | 2009 |
Nicotine withdrawal and kappa-opioid receptors.
Topics: Adenylyl Cyclase Inhibitors; Animals; Basal Ganglia; Benzeneacetamides; Caudate Nucleus; Dynorphins; GTP-Binding Proteins; Male; Mice; Nicotine; Nucleus Accumbens; Putamen; Pyrrolidines; Receptors, Opioid, kappa; RNA, Messenger; Substance Withdrawal Syndrome | 2010 |
Activation of κ opioid receptors increases intrinsic excitability of dentate gyrus granule cells.
Topics: 4-Aminopyridine; Action Potentials; Animals; Benzeneacetamides; Dentate Gyrus; Dynorphins; GTP-Binding Proteins; Guanosine Diphosphate; Male; Mice; Mice, 129 Strain; Naltrexone; Neurons; Patch-Clamp Techniques; Potassium Channels; Pyrrolidines; Receptors, Opioid, kappa; Thionucleotides | 2011 |
Regulation of arcuate neurons coexpressing kisspeptin, neurokinin B, and dynorphin by modulators of neurokinin 3 and κ-opioid receptors in adult male mice.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Benzeneacetamides; Dynorphins; Gonadotropin-Releasing Hormone; Green Fluorescent Proteins; Kisspeptins; Male; Membrane Potentials; Mice; Mice, Transgenic; Neurokinin B; Neurons; Orchiectomy; Peptide Fragments; Pyrrolidines; Receptors, Neurokinin-3; Receptors, Opioid, kappa; Substance P; Time Factors | 2013 |
Kappa opioid receptor activation decreases inhibitory transmission and antagonizes alcohol effects in rat central amygdala.
Topics: Amygdala; Animals; Benzeneacetamides; Dynorphins; Ethanol; Inhibitory Postsynaptic Potentials; Male; Naltrexone; Narcotic Antagonists; Patch-Clamp Techniques; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2014 |
Zyklophin, a short-acting kappa opioid antagonist, induces scratching in mice.
Topics: Animals; Benzeneacetamides; Dose-Response Relationship, Drug; Dynorphins; Injections, Subcutaneous; Male; Mice; Mice, Knockout; Naltrexone; Peptide Fragments; Pruritus; Pyrrolidines; Radioligand Assay; Receptors, Opioid, kappa | 2014 |
Characterization of kappa opioid receptor mediated, dynorphin-stimulated [35S]GTPγS binding in mouse striatum for the evaluation of selective KOR ligands in an endogenous setting.
Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Corpus Striatum; Drug Evaluation, Preclinical; Dynorphins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice, Inbred C57BL; Mice, Knockout; Narcotic Antagonists; Protein Binding; Pyrrolidines; Receptors, Opioid, kappa; Signal Transduction; Sulfur Radioisotopes | 2015 |
Cloning and pharmacological characterization of a rat kappa opioid receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Analgesics; Animals; Benzeneacetamides; Cell Line; Cell Membrane; Cloning, Molecular; Corpus Striatum; Cyclic AMP; DNA Primers; DNA, Complementary; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gene Library; In Situ Hybridization; Inositol 1,4,5-Trisphosphate; Kinetics; Ligands; Molecular Sequence Data; Pyrrolidines; Rats; Receptors, Opioid, kappa; Restriction Mapping; RNA, Messenger; Transfection | 1993 |
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.
Topics: Animals; Aorta, Thoracic; Cocaine; Cyclic AMP; Electric Stimulation; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Opioid-Related Disorders; Rats; Receptors, Dopamine; Receptors, Opioid; Receptors, Serotonin; Substance-Related Disorders | 1998 |
Isosteric replacement of acidic with neutral residues in extracellular loop-2 of the kappa-opioid receptor does not affect dynorphin A(1-13) affinity and function.
Topics: Amino Acid Sequence; Cell Line; Dynorphins; Humans; Molecular Sequence Data; Peptide Fragments; Point Mutation; Polymerase Chain Reaction; Radioligand Assay; Receptors, Opioid, kappa; Structure-Activity Relationship | 2000 |
Chemotype-selective modes of action of κ-opioid receptor agonists.
Topics: Analgesics, Opioid; Binding Sites; Crystallography, X-Ray; Dynorphins; HEK293 Cells; Humans; Ligands; Molecular Docking Simulation; Mutagenesis, Site-Directed; Mutation; Protein Conformation; Receptors, Opioid, kappa; Structure-Activity Relationship | 2013 |