u 69593 has been researched along with diprenorphine in 16 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.25) | 18.7374 |
| 1990's | 10 (62.50) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 3 (18.75) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Adapa, ID; Auh, JS; Berzetei-Gurske, IP; Brandt, SR; Craymer, K; Farrington, L; Haggart, D; Kennedy, JM; O'Brien, A; Polgar, WE; Rodriguez, L; Schwartz, RW; Toll, L; White, A | 1 |
| Ferguson, DM; Kramer, S; Law, PY; Metzger, TG; Portoghese, PS | 1 |
| Aubé, J; Frankowski, KJ; Katritch, V; Mosier, PD; Roth, BL; Stevens, RC; Vardy, E; Westkaemper, RB; Wu, H | 1 |
| Che, T; Kalinin, DV; Loser, K; Mykicki, N; Schepmann, D; Ständer, S; Tangherlini, G; Wünsch, B | 1 |
| Caudle, RM; Chavkin, C; Wagner, JJ | 1 |
| Dissanayake, VU; Hughes, J; Hunter, JC | 1 |
| Barg, J; Simantov, R | 1 |
| Rodriguez, FD; Traynor, JR; Wood, MS | 1 |
| Iwai, T; Luay, AE; Niwa, M; Nozaki, M; Tsurumi, K | 1 |
| Chen, C; DeRiel, JK; Kunapuli, S; Liu-Chen, LY; Xue, JC; Yu, L; Zhu, J | 1 |
| Ishige, K; Ito, Y; Makimura, M; Murakoshi, Y | 1 |
| Cho, KP; Eun, JS; Eun, YA; Kim, KW; Soh, SM | 1 |
| Blake, AD; Bot, G; Freeman, JC; Li, S; Reisine, T | 1 |
| Andria, ML; Hiller, JM; Onoprishvili, I; Simon, EJ; Vilim, FS | 1 |
| Howells, RD; Wannemacher, KM; Yadav, PN | 1 |
| Ansonoff, MA; Pintar, JE; Wen, T | 1 |
16 other study(ies) available for u 69593 and diprenorphine
| Article | Year |
|---|---|
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.
Topics: Animals; Aorta, Thoracic; Cocaine; Cyclic AMP; Electric Stimulation; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Opioid-Related Disorders; Rats; Receptors, Dopamine; Receptors, Opioid; Receptors, Serotonin; Substance-Related Disorders | 1998 |
Isosteric replacement of acidic with neutral residues in extracellular loop-2 of the kappa-opioid receptor does not affect dynorphin A(1-13) affinity and function.
Topics: Amino Acid Sequence; Cell Line; Dynorphins; Humans; Molecular Sequence Data; Peptide Fragments; Point Mutation; Polymerase Chain Reaction; Radioligand Assay; Receptors, Opioid, kappa; Structure-Activity Relationship | 2000 |
Chemotype-selective modes of action of κ-opioid receptor agonists.
Topics: Analgesics, Opioid; Binding Sites; Crystallography, X-Ray; Dynorphins; HEK293 Cells; Humans; Ligands; Molecular Docking Simulation; Mutagenesis, Site-Directed; Mutation; Protein Conformation; Receptors, Opioid, kappa; Structure-Activity Relationship | 2013 |
Development of Novel Quinoxaline-Based κ-Opioid Receptor Agonists for the Treatment of Neuroinflammation.
Topics: Animals; Antineoplastic Agents; Binding Sites; Encephalomyelitis, Autoimmune, Experimental; HEK293 Cells; Humans; Interferon-gamma; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Docking Simulation; Protein Structure, Tertiary; Quinoxalines; Receptors, Opioid, kappa; Signal Transduction; Structure-Activity Relationship; Th1 Cells | 2019 |
Kappa-opioids decrease excitatory transmission in the dentate gyrus of the guinea pig hippocampus.
Topics: Action Potentials; Animals; Benzeneacetamides; Diprenorphine; Dynorphins; Electrophysiology; Endorphins; Guinea Pigs; Hippocampus; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Synapses | 1992 |
Opioid binding sites in the guinea pig and rat kidney: radioligand homogenate binding and autoradiography.
Topics: Analgesics; Animals; Autoradiography; Benzeneacetamides; Binding, Competitive; Cations; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Guinea Pigs; Kidney; Kinetics; Narcotic Antagonists; Nucleotides; Pyrrolidines; Radioligand Assay; Rats; Receptors, Opioid; Receptors, Opioid, delta; Tritium | 1991 |
Depolarization regulates selectively the expression of different opioid receptors: a decreased number of kappa receptors in chronically activated guinea pig brain cell cultures.
Topics: Animals; Benzeneacetamides; Brain; Cells, Cultured; Diprenorphine; Gene Expression Regulation; Guinea Pigs; Membrane Potentials; Potassium; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa | 1990 |
Characterisation of kappa-opioid binding sites in rat and guinea-pig spinal cord.
Topics: Animals; Benzeneacetamides; Benzomorphans; Captopril; Diprenorphine; Dynorphins; Guinea Pigs; In Vitro Techniques; Leucine; Ligands; Male; Peptide Fragments; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Spinal Cord | 1989 |
Characterization of opioid receptors in the Mongolian gerbil cerebellum.
Topics: Animals; Autoradiography; Benzeneacetamides; Binding Sites; Binding, Competitive; Cerebellum; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gerbillinae; Guanylyl Imidodiphosphate; In Vitro Techniques; Narcotics; Pyrrolidines; Radioligand Assay; Receptors, Opioid; Receptors, Opioid, mu | 1994 |
Differential binding domains of peptide and non-peptide ligands in the cloned rat kappa opioid receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Animals; Base Sequence; Benzeneacetamides; Binding Sites; Binding, Competitive; Cell Line; Chlorocebus aethiops; Cloning, Molecular; Diprenorphine; DNA Primers; Dynorphins; Endorphins; Kinetics; Ligands; Molecular Sequence Data; Naltrexone; Polymerase Chain Reaction; Protein Conformation; Protein Structure, Secondary; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Fusion Proteins; Transfection | 1994 |
Inhibitory effects of NaCl and guanyl-5'yl-imidodiphosphate (GppNHp) on [3H]naloxone binding to kappa-opioid receptors in guinea pig cerebellum.
Topics: Animals; Benzeneacetamides; Binding Sites; Cerebellum; Cerebral Cortex; Corpus Striatum; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylmaleimide; Guanylyl Imidodiphosphate; Guinea Pigs; Male; Naloxone; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Sodium Chloride | 1993 |
Ligand binding profiles of U-69, 593-sensitive and-insensitive sites in human cerebral cortex membranes: evidence of kappa opioid receptors heterogeneity.
Topics: Analgesics; Benzeneacetamides; Cell Membrane; Cerebral Cortex; Diprenorphine; Humans; In Vitro Techniques; Protein Binding; Pyrrolidines; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium | 1996 |
Differential agonist regulation of the human kappa-opioid receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylate Cyclase Toxin; Benzeneacetamides; Cell Line; Cyclic AMP; Diprenorphine; Dynorphins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Levorphanol; Narcotic Antagonists; Narcotics; Pertussis Toxin; Pyrrolidines; Receptors, Opioid, kappa; Virulence Factors, Bordetella | 1997 |
The bovine mu-opioid receptor: cloning of cDNA and pharmacological characterization of the receptor expressed in mammalian cells.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Analgesics, Opioid; Animals; Base Sequence; Benzeneacetamides; Binding, Competitive; Cattle; Cell Line; Cell Membrane; Cloning, Molecular; Colforsin; Corpus Striatum; Diprenorphine; DNA, Complementary; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Gene Expression; Gene Expression Regulation; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Molecular Sequence Data; Pyrrolidines; Radioligand Assay; Receptors, Opioid, mu; Recombinant Fusion Proteins; Sequence Alignment; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Sulfur Radioisotopes; Tritium | 1999 |
A select set of opioid ligands induce up-regulation by promoting the maturation and stability of the rat kappa-opioid receptor in human embryonic kidney 293 cells.
Topics: Animals; Benzeneacetamides; Brefeldin A; Cells, Cultured; Cycloheximide; Diprenorphine; Humans; Ligands; Naloxone; Naltrexone; Pyrrolidines; Rats; Receptors, Opioid, kappa; RNA, Messenger; Transfection; Up-Regulation | 2007 |
Kappa2 opioid receptor subtype binding requires the presence of the DOR-1 gene.
Topics: Analysis of Variance; Animals; Benzeneacetamides; Diprenorphine; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Mice; Mice, Knockout; Pain Measurement; Protein Binding; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Regression Analysis | 2010 |