Compounds > u 54494a

Page last updated: 2024-09-03

u 54494a and u-50488

u 54494a has been researched along with u-50488 in 8 studies

Compound Research Comparison

Studies (u 54494a)	Trials (u 54494a)	Recent Studies (post-2010) (u 54494a)	Studies (u-50488)	Trials (u-50488)	Recent Studies (post-2010) (u-50488)
21	0	0	1,664	3	209

Protein Interaction Comparison

Protein	Taxonomy	u 54494a (IC50)	u-50488 (IC50)
Delta-type opioid receptor	Rattus norvegicus (Norway rat)		2.15
Kappa-type opioid receptor	Mus musculus (house mouse)		0.0027
Mu-type opioid receptor	Rattus norvegicus (Norway rat)		2.15
Kappa-type opioid receptor	Rattus norvegicus (Norway rat)		0.7171
Kappa-type opioid receptor	Cavia porcellus (domestic guinea pig)		0.0958
Kappa-type opioid receptor	Homo sapiens (human)		0.0537

Research

Studies (8)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (25.00)	18.7374
1990's	6 (75.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Aaron, CS; Camacho Ochoa, M; Jackson, TA; Lahti, RA; Strain, GM; Von Voigtlander, PF	1
Lum, JT; Ochoa, MC; Piercey, MF; Vogelsang, GD; VonVoigtlander, PF	1
Frank, C; Proietti, ML; Sagratella, S; Scotti de Carolis, A; Zeng, YC	1
Althaus, JS; Hudson, CJ; Means, ED; Scherch, HM; Von Voigtlander, PF	1
Hall, ED; Lewis, RA; Ochoa, MC; Triezenberg, HJ; VonVoigtlander, PF	1
Hall, ED; Pazara, KE	1
Brusa, L; D'Amore, A; Lorenzini, P; Massotti, M	1
De Sarro, A; De Sarro, G; Masuda, Y; Sinopoli, S; Trimarchi, GR	1

Other Studies

8 other study(ies) available for u 54494a and u-50488

Article	Year
Antagonism of kainic acid lesions in the mouse hippocampus by U-54494A and U-50488H. Life sciences, 1992, Volume: 51, Issue:14 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Hippocampus; Image Processing, Computer-Assisted; Injections, Intraventricular; Kainic Acid; Male; Mice; Neuroglia; Neurons; Pyrrolidines; Receptors, Opioid; Seizures; Vacuoles	1992
Effect of the anticonvulsant U-54494A on cortical neuron excitability: comparison to the kappa agonist U-50488H. Life sciences, 1992, Volume: 50, Issue:17 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Action Potentials; Analgesics; Animals; Anticonvulsants; Cerebral Cortex; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Injections, Intravenous; Iontophoresis; Male; Neural Conduction; Neurons; Procaine; Pyrrolidines; Rabbits; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa	1992
In vitro depressant effects of U-54494A, an anticonvulsant related to kappa opioids, in the hippocampus. Neuropharmacology, 1991, Volume: 30, Issue:6 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Anticonvulsants; Azocines; Calcium; Cell Membrane; Depression, Chemical; Electric Stimulation; Female; Hippocampus; In Vitro Techniques; Membrane Potentials; Naltrexone; Narcotic Antagonists; Neurons; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Synapses; Synaptic Transmission	1991
The kappa opioid-related anticonvulsants U-50488H and U-54494A attenuate N-methyl-D-aspartate induced brain injury in the neonatal rat. Brain research, 1991, Nov-15, Volume: 564, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Animals, Newborn; Brain; Brain Diseases; Diuresis; Dose-Response Relationship, Drug; N-Methylaspartate; Organ Size; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Staining and Labeling	1991
U-54494A: a unique anticonvulsant related to kappa opioid agonists. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 243, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anticonvulsants; Calcium; Kainic Acid; Male; Muscle Contraction; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa	1987
Quantitative analysis of effects of kappa-opioid agonists on postischemic hippocampal CA1 neuronal necrosis in gerbils. Stroke, 1988, Volume: 19, Issue:8 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain Ischemia; Gerbillinae; Hippocampus; Male; Necrosis; Neurons; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa	1988
Area tempestas modulates the behavioural responses to nociceptive stimuli in rats. Annali dell'Istituto superiore di sanita, 1993, Volume: 29, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anticonvulsants; Azocines; Bicuculline; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Escape Reaction; Foot; Hot Temperature; Male; Morphine; Naltrexone; Narcotic Antagonists; Olfactory Pathways; Pain; Phenazocine; Pressure; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid; Seizures; Tail	1993
Anticonvulsant effects of U-54494A and U-50488H in genetically epilepsy-prone rats and DBA/2 mice: a possible involvement of glycine/NMDA receptor complex. General pharmacology, 1993, Volume: 24, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anticonvulsants; Epilepsy; Female; Male; Mice; Mice, Inbred DBA; Motor Activity; Naloxone; Naltrexone; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Opioid, kappa; Serine	1993