u 54494a and u-50488
u 54494a has been researched along with u-50488 in 8 studies
Compound Research Comparison
| Studies (u 54494a) | Trials (u 54494a) | Recent Studies (post-2010) (u 54494a) | Studies (u-50488) | Trials (u-50488) | Recent Studies (post-2010) (u-50488) |
|---|---|---|---|---|---|
| 21 | 0 | 0 | 1,664 | 3 | 209 |
Protein Interaction Comparison
| Protein | Taxonomy | u 54494a (IC50) | u-50488 (IC50) |
|---|---|---|---|
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | 2.15 | |
| Kappa-type opioid receptor | Mus musculus (house mouse) | 0.0027 | |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | 2.15 | |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | 0.7171 | |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.0958 | |
| Kappa-type opioid receptor | Homo sapiens (human) | 0.0537 |
Research
Studies (8)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (25.00) | 18.7374 |
| 1990's | 6 (75.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Aaron, CS; Camacho Ochoa, M; Jackson, TA; Lahti, RA; Strain, GM; Von Voigtlander, PF | 1 |
| Lum, JT; Ochoa, MC; Piercey, MF; Vogelsang, GD; VonVoigtlander, PF | 1 |
| Frank, C; Proietti, ML; Sagratella, S; Scotti de Carolis, A; Zeng, YC | 1 |
| Althaus, JS; Hudson, CJ; Means, ED; Scherch, HM; Von Voigtlander, PF | 1 |
| Hall, ED; Lewis, RA; Ochoa, MC; Triezenberg, HJ; VonVoigtlander, PF | 1 |
| Hall, ED; Pazara, KE | 1 |
| Brusa, L; D'Amore, A; Lorenzini, P; Massotti, M | 1 |
| De Sarro, A; De Sarro, G; Masuda, Y; Sinopoli, S; Trimarchi, GR | 1 |
Other Studies
8 other study(ies) available for u 54494a and u-50488
| Article | Year |
|---|---|
Antagonism of kainic acid lesions in the mouse hippocampus by U-54494A and U-50488H.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Hippocampus; Image Processing, Computer-Assisted; Injections, Intraventricular; Kainic Acid; Male; Mice; Neuroglia; Neurons; Pyrrolidines; Receptors, Opioid; Seizures; Vacuoles | 1992 |
Effect of the anticonvulsant U-54494A on cortical neuron excitability: comparison to the kappa agonist U-50488H.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Action Potentials; Analgesics; Animals; Anticonvulsants; Cerebral Cortex; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Injections, Intravenous; Iontophoresis; Male; Neural Conduction; Neurons; Procaine; Pyrrolidines; Rabbits; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1992 |
In vitro depressant effects of U-54494A, an anticonvulsant related to kappa opioids, in the hippocampus.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Anticonvulsants; Azocines; Calcium; Cell Membrane; Depression, Chemical; Electric Stimulation; Female; Hippocampus; In Vitro Techniques; Membrane Potentials; Naltrexone; Narcotic Antagonists; Neurons; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Synapses; Synaptic Transmission | 1991 |
The kappa opioid-related anticonvulsants U-50488H and U-54494A attenuate N-methyl-D-aspartate induced brain injury in the neonatal rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Animals, Newborn; Brain; Brain Diseases; Diuresis; Dose-Response Relationship, Drug; N-Methylaspartate; Organ Size; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Staining and Labeling | 1991 |
U-54494A: a unique anticonvulsant related to kappa opioid agonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anticonvulsants; Calcium; Kainic Acid; Male; Muscle Contraction; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa | 1987 |
Quantitative analysis of effects of kappa-opioid agonists on postischemic hippocampal CA1 neuronal necrosis in gerbils.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain Ischemia; Gerbillinae; Hippocampus; Male; Necrosis; Neurons; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa | 1988 |
Area tempestas modulates the behavioural responses to nociceptive stimuli in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anticonvulsants; Azocines; Bicuculline; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Escape Reaction; Foot; Hot Temperature; Male; Morphine; Naltrexone; Narcotic Antagonists; Olfactory Pathways; Pain; Phenazocine; Pressure; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid; Seizures; Tail | 1993 |
Anticonvulsant effects of U-54494A and U-50488H in genetically epilepsy-prone rats and DBA/2 mice: a possible involvement of glycine/NMDA receptor complex.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anticonvulsants; Epilepsy; Female; Male; Mice; Mice, Inbred DBA; Motor Activity; Naloxone; Naltrexone; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Opioid, kappa; Serine | 1993 |